Farid Amansyah, B Budu, Muhammad Harun Achmad, Nu Man A S Daud, Agung Putra, Muhammad Nasrum Massi, Agussalim Bukhari, Marhaen Hardjo, Luthfi Parewangi, Ilhamjaya Patellongi
<b>Background and Objective:</b> Liver fibrosis (LF) is a most common pathological process characterized by the activation of hepatocytes leading to the accumulation of extracellular matrix (ECM). Hypoxia precondition treated in MSCs (H-MSCs) could enhance their immunomodulatory and regeneration capability, through expressing robust anti-inflammatory cytokines and growth factors, known as H-MSCs secretome (SH-MSCs) that are critical for the improvement of liver fibrosis. However, the study regarding the efficacy and mechanism of action of SH-MSCs in ameliorating liver fibrosis is still inconclusive...
January 2024: Pakistan Journal of Biological Sciences: PJBS