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Clinical & Translational Oncology

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https://www.readbyqxmd.com/read/28093702/rabies-virus-vaccine-as-an-immune-adjuvant-against-cancers-and-glioblastoma-new-studies-may-resurrect-a-neglected-potential
#1
REVIEW
M A Altinoz, S Guloksuz, I Elmaci
To review the literature about the use of Rabies Virus-Vaccine (RV-V) as an anticancer immunotherapeutic modality in the light of recent findings. The literature search in relevant databases with the following key words: Rabies virus, cancer, remission. Remissions occured following RV-V injections in patients with cervical cancer and melanoma. Pilot clinical studies showed that RV-V injections enhanced survival in glioblastoma patients, which is supported by findings in GL261 mouse glioma model. If public health studies demonstrate protective role of RV-V against certain types of cancers, it can be benefitted as a novel immune adjuvant in clinic...
January 16, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28093701/cancer-incidence-in-spain-2015
#2
J Galceran, A Ameijide, M Carulla, A Mateos, J R Quirós, D Rojas, A Alemán, A Torrella, M Chico, M Vicente, J M Díaz, N Larrañaga, R Marcos-Gragera, M J Sánchez, J Perucha, P Franch, C Navarro, E Ardanaz, J Bigorra, P Rodrigo, R Peris Bonet
PURPOSE: Periodic cancer incidence estimates of Spain from all existing population-based cancer registries at any given time are required. The objective of this study was to present the current situation of cancer incidence in Spain. METHODS: The Spanish Network of Cancer Registries (REDECAN) estimated the numbers of new cancer cases occurred in Spain in 2015 by applying the incidence-mortality ratios method. In the calculus, incidence data from population-based cancer registries and mortality data of all Spain were used...
January 16, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28093700/postdiagnostic-use-of-%C3%AE-blockers-and-other-antihypertensive-drugs-and-the-risk-of-recurrence-and-mortality-in-head-and-neck-cancer-patients-an-observational-study-of-10-414-person-years-of-follow-up
#3
S-A Kim, H Moon, J-L Roh, S-B Kim, S-H Choi, S Y Nam, S Y Kim
INTRODUCTION: Growing evidence indicates that norepinephrine promotes cancer growth and metastasis whereas β-blockers decrease these risks. This study aimed to examine the clinical impact of β-blockers and other hypertensive drugs on disease recurrence and survival in patients with head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: This study analyzed a cohort of 1274 consecutive patients who received definitive treatments for previously untreated HNSCC at our tertiary referral center between January 2001 and December 2012...
January 16, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28091898/the-outcomes-of-radiotherapy-and-factors-that-predict-overall-survival-in-elderly-patients-with-esophageal-squamous-cell-carcinoma
#4
H Yin, M E, H Zhang, C Wang
PURPOSE: The aim of this study was to evaluate radiotherapy in terms of both feasibility and efficacy for the treatment of 206 elderly patients (≥70 years) with unresectable ESCC and to investigate the factors that predict overall survival in those patients. METHODS: Totally, 206 elderly patients with esophageal cancer (≥70 years) treated with RT for ESCC in the Harbin Medical University Affiliated Tumor Hospital were retrospectively enrolled. Radiation treatment results and side effects were evaluated...
January 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28083756/the-oncology-day-hospital-in-spain-an-updated-analysis-of-spanish-society-of-medical-oncology-seom-looking-forward
#5
EDITORIAL
C Jara, F Ayala, J A Virizuela
No abstract text is available yet for this article.
January 12, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28074400/peculiarities-of-the-obese-patient-with-cancer-a-national-consensus-statement-by-the-spanish-society-for-the-study-of-obesity-and-the-spanish-society-of-medical-oncology
#6
P Pérez-Segura, J E Palacio, L Vázquez, S Monereo, R de Las Peñas, P Martínez de Icaya, C Grávalos, A Lecube, A Blasco, J M García-Almeida, I Barneto, A Goday
The relationship between obesity and cancer is clear and is present at all times during course of the disease. The importance of obesity in increasing the risk of developing cancer is well known, and some of the most prevalent tumours (breast, colorectal, and prostate) are directly related to this risk increase. However, there is less information available on the role that obesity plays when the patient has already been diagnosed with cancer. Certain data demonstrate that in some types of cancer, obese patients tolerate the treatments more poorly...
January 10, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28070766/radiofrequency-ablation-combined-with-transarterial-chemoembolization-versus-hepatectomy-for-patients-with-hepatocellular-carcinoma-within-milan-criteria-a-retrospective-case-control-study
#7
A K Bholee, K Peng, Z Zhou, J Chen, L Xu, Y Zhang, M Chen
PROPOSAL: To compare the effectiveness of TACE + RFA with hepatectomy in patients with HCC within Milan criteria. METHODS: It is a retrospective matched case-control study from January 2006 to December 2010 in a tertiary cancer center. 74 patients with HCC within Milan criteria initially treated with TACE + RFA were identified and compared with 148 matched controls selected from a pool of 782 patients who received hepatectomy. Patients were matched with respect to age, gender, tumor size and number, AFP and liver function test...
January 9, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28054321/impact-of-clinicopathological-parameters-on-survival-after-multiorgan-resection-among-patients-with-t4-gastric-carcinoma-a-systematic-review-and-meta-analysis
#8
REVIEW
G Zu, T Zhang, W Li, Y Sun, X Zhang
BACKGROUND: The prognostic factors which can improve the overall survival (OS) of patients with T4 gastric carcinoma (GC) are still controversial: a meta-analysis was conducted to analyze the impact of clinicopathological parameters on survival after MOR among patients with T4 GC. METHODS: A systematic search was performed. Odd risks (ORs) of patients with T4 GC were used to calculate the relationship between clinicopathological parameters and OS. RESULTS: Nine studies involving 941 patients with T4 GC were identified...
January 4, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28054320/pembrolizumab-for-advanced-melanoma-experience-from-the-spanish-expanded-access-program
#9
M González-Cao, A Arance, J M Piulats, I Marquez-Rodas, J L Manzano, A Berrocal, G Crespo, D Rodriguez, E Perez-Ruiz, M Berciano, A Soria, A G Castano, E Espinosa, C Montagut, L Alonso, T Puertolas, C Aguado, M A Royo, R Blanco, J F Rodríguez, E Muñoz, P Mut, F Barron, S Martin-Algarra
BACKGROUND: The programmed death (PD-1) inhibitor pembrolizumab has been recently approved for the treatment of advanced melanoma. We evaluated the clinical activity of pembrolizumab in melanoma patients treated under the Spanish Expanded Access Program. METHODS: Advanced melanoma patients who failed to previous treatment lines were treated with pembrolizumab 2 mg/kg every three weeks. Patients with brain metastases were not excluded if they were asymptomatic. Data were retrospectively collected from 21 centers in the Spanish Melanoma Group...
January 4, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28054319/exosomal-micrornas-in-liquid-biopsies-future-biomarkers-for-prostate-cancer
#10
REVIEW
A Valentino, P Reclusa, R Sirera, M Giallombardo, C Camps, P Pauwels, S Crispi, C Rolfo
Prostate cancer is the second most diagnosed cancer in males in the world. Plasma quantification of prostate-specific antigen substantially improved the early detection of prostate cancer, but still lacks the required specificity. Clinical management of prostate cancer needs advances in the development of new non-invasive biomarkers, ameliorating current diagnosis and prognosis and guiding therapeutic decisions. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the post-transcriptional level...
January 4, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28054318/treating-patients-with-alk-rearranged-non-small-cell-lung-cancer-mechanisms-of-resistance-and-strategies-to-overcome-it
#11
REVIEW
M Drizou, E A Kotteas, N Syrigos
Anaplastic lymphoma kinase (ALK) rearrangement is detected in 3-7% of patients with non-small-cell lung cancer. Crizotinib is an ALK inhibitor, which was approved in 2011 for the treatment of ALK-positive lung cancer. Despite the initial enthusiasm, most of the patients develop resistance within the first year of treatment. The main mechanisms are secondary mutations and bypass track activation. Moreover, crizotinib has low penetration into the central nervous system. The need to overcome these limitations has led to the development of second-generation inhibitors that have better effectiveness against crizotinib-resistant mutations and brain metastases...
January 4, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28005261/results-of-a-multicenter-survey-showing-interindividual-variability-among-neurosurgeons-when-deciding-on-the-radicality-of-surgical-resection-in-glioblastoma-highlight-the-need-for-more-objective-guidelines
#12
J Capellades, P Teixidor, G Villalba, C Hostalot, G Plans, R Armengol, S Medrano, A Estival, R Luque, S Gonzalez, M Gil-Gil, S Villa, J Sepulveda, J J García-Mosquera, C Balana
PURPOSE: We assessed agreement among neurosurgeons on surgical approaches to individual glioblastoma patients and between their approach and those recommended by the topographical staging system described by Shinoda. METHODS: Five neurosurgeons were provided with pre-surgical MRIs of 76 patients. They selected the surgical approach [biopsy, partial resection, or gross total resection (GTR)] that they would recommend for each patient. They were blinded to each other's response and they were told that patients were younger than 50 years old and without symptoms...
December 22, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28005260/high-early-growth-response-1-egr1-expression-correlates-with-resistance-to-anti-egfr-treatment-in-vitro-and-with-poorer-outcome-in-metastatic-colorectal-cancer-patients-treated-with-cetuximab
#13
S S Kumar, Y Tomita, J Wrin, M Bruhn, A Swalling, M Mohammed, T J Price, J E Hardingham
PURPOSE: Biomarkers, such as mutant RAS, predict resistance to anti-EGFR therapy in only a proportion of patients, and hence, other predictive biomarkers are needed. The aims were to identify candidate genes upregulated in colorectal cancer cell lines resistant to anti-EGFR monoclonal antibody treatment, to knockdown (KD) these genes in the resistant cell lines to determine if sensitivity to anti-EGFR antibody was restored, and finally to perform a pilot correlative study of EGR1 expression and outcomes in a cohort of metastatic colorectal cancer (mCRC) patients given cetuximab therapy...
December 22, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28005259/medical-oncology-future-plan-of-the-spanish-society-of-medical-oncology-challenges-and-future-needs-of-the-spanish-oncologists
#14
REVIEW
F Rivera, R Andres, E Felip, R Garcia-Campelo, P Lianes, A Llombart, J M Piera, J Puente, C A Rodriguez, R Vera, J A Virizuela, M Martin, P Garrido
PURPOSE: The SEOM Future Plan is aimed at identifying the main challenges, trends and needs of the medical oncology speciality over the next years, including potential oncologist workforce shortages, and proposing recommendations to overcome them. METHODS: The estimations of the required medical oncologists workforce are based on an updated Medical Oncologist Register in Spain, Medical Oncology Departments activity data, dedication times and projected cancer incidence...
December 22, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27995549/consensus-guidelines-for-diagnosis-treatment-and-follow-up-of-patients-with-pancreatic-cancer-in-spain
#15
M Hidalgo, R Álvarez, J Gallego, C Guillén-Ponce, B Laquente, T Macarulla, A Muñoz, M Salgado, R Vera, J Adeva, I Alés, S Arévalo, J Blázquez, A Calsina, A Carmona, E de Madaria, R Díaz, L Díez, T Fernández, B G de Paredes, M E Gallardo, I González, O Hernando, P Jiménez, A López, C López, F López-Ríos, E Martín, J Martínez, A Martínez, J Montans, R Pazo, J C Plaza, I Peiró, J J Reina, A Sanjuanbenito, R Yaya, Alfredo Carrato
The management of patients with pancreatic cancer has advanced over the last few years. We convey a multidisciplinary group of experts in an attempt to stablish practical guidelines for the diagnoses, staging and management of these patients. This paper summarizes the main conclusions of the working group. Patients with suspected pancreatic ductal adenocarcinoma should be rapidly evaluated and referred to high-volume centers. Multidisciplinary supervision is critical for proper diagnoses, staging and to frame a treatment plan...
December 19, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27943096/gastrointestinal-stromal-tumors-gists-seap-seom-consensus-on-pathologic-and-molecular-diagnosis
#16
J Martin-Broto, V Martinez-Marín, C Serrano, N Hindi, J A López-Guerrero, R Ramos-Asensio, A Vallejo-Benítez, D Marcilla-Plaza, R González-Cámpora
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the digestive tract, with an incidence of 1.1 cases/100,000 inhabitants/year. A group of experts from the Spanish Society of Pathology and the Spanish Society of Oncology met to discuss a brief update on GISTs and agree on aspects relating to the pathological and molecular diagnosis of these tumors. GISTs are generally solitary, well-circumscribed lesions of variable size (<10 mm-35 cm) that may present with intra- or extra-luminal parietal growth or a mixed-type (hourglass) growth pattern...
December 9, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27921232/biological-function-and-mechanism-of-mir-33a-in-prostate-cancer-survival-and-metastasis-via-downregulating-engrailed-2
#17
Q Li, S Lu, X Li, G Hou, L Yan, W Zhang, B Qiao
OBJECTIVE: Recent studies have identified Engrailed-2 (EN-2), a homeobox-containing transcription factor, as a candidate oncogene in prostate cancer (PC). Therapeutic targeting on EN-2, however, is limited because the mechanism underlying EN-2 overexpression in prostatic cancer cells is unknown. This study was to investigate the potential regulatory role of miR-33a on EN-2 expression and explore this signaling axis in ability of prostate cancer survival and metastasis. METHODS: The relative expression of miR-33a and EN-2 in paired prostate cancer tissue and adjacent normal tissue as well as in prostate cancer cell lines, PC3 and DU145, was determined using quantitative real-time PCR or western blot, respectively...
December 5, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27909873/neutrophil-to-lymphocyte-ratio-associated-with-prognosis-of-lung-cancer
#18
V Bar-Ad, J Palmer, L Li, Y Lai, B Lu, R E Myers, Z Ye, R Axelrod, J M Johnson, M Werner-Wasik, S W Cowan, N R Evans, B T Hehn, C C Solomides, C Wang
PURPOSE: Many studies recently focus on complicated and expensive genomic tests, but the prognostic values of biochemical markers which are easily obtained in clinics are largely overlooked and without further exploration. This study assesses the association of neutrophil-lymphocyte-ratio (NLR) with prognosis of lung cancer patients. METHODS: In 1032 patients with histologically confirmed lung cancer, the association of pretreatment NLR values with overall survival (OS) was evaluated using a Cox proportional hazards model and the temporal relationship of longitudinal NLR was assessed using a mixed effects model...
December 1, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27896643/a-novel-signaling-role-for-mir-451-in-esophageal-tumor-microenvironment-and-its-contribution-to-tumor-progression
#19
S Khazaei, N Nouraee, A Moradi, S J Mowla
OBJECTIVE: We evaluated miR-451 expression in serum and tissue samples of esophageal squamous cell carcinoma (ESCC) patients. Then, we examined a secretory role of miR-451 in esophageal tumor microenvironment. METHODS: miR-451 expression was evaluated in 39 serum samples from esophageal SCC patients compared to 39 normal individuals as well as 26 pairs of fresh-frozen tumor and adjacent normal tissues from patients with ESCC, using qRT-PCR. In a co-culture system of human normal fibroblasts (HFSF-PI3) and esophageal cancer cell line (KYSE-30), we evaluated exosomal miR-451 secretion into the conditioned medium (CM) of both cell lines...
November 28, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27896640/role-of-axillary-ultrasound-magnetic-resonance-imaging-and-ultrasound-guided-fine-needle-aspiration-biopsy-in-the-preoperative-triage-of-breast-cancer-patients
#20
I Barco, C Chabrera, A García-Fernández, M Fraile, S González, L Canales, J M Lain, C González, M C Vidal, E Vallejo, J Deu, A Pessarrodona, N Giménez, M García Font
PURPOSE: Roughly two-thirds of early breast cancer cases are associated with negative axillary nodes and do not benefit from axillary surgery at all. Accordingly, there is an ongoing search for non-surgical staging procedures to avoid lymph-node dissection or sentinel node biopsy (SNB). Non-invasive imaging techniques with very high sensitivity (Se) and negative predictive value (NPV) could eventually replace SNB. We aimed to establish the role of axillary US and MRI, alone or in combination, associated with ultrasound-guided fine-needle aspiration biopsy (US-FNAB) in the prediction of axillary node involvement...
November 28, 2016: Clinical & Translational Oncology
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