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Clinical & Translational Oncology

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https://www.readbyqxmd.com/read/28432572/micropapillary-bladder-cancer-a-clinico-pathological-characterization-and-treatment-analysis
#1
Z Li, H Liao, Z Tan, D Mao, Y Wu, Y M Xiao, S K Yang, L Zhong
PURPOSE: Micropapillary bladder cancer (MPBC) is a very rare and aggressive variant of urothelial carcinoma (UC). The aim of this study was to investigate the clinico-pathological characteristics, treatment, and prognosis of MPBC to improve the understanding of this invasive disease. METHODS: We reviewed the records of 6 patients with MPBC who were evaluated and treated at our hospital between 2009 and 2015, and additionally reviewed 38 cases reported in the literature...
April 21, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28421416/emergence-of-ctnnb1-mutation-at-acquired-resistance-to-kit-inhibitor-in-metastatic-melanoma
#2
J Cho, S Y Kim, Y J Kim, M H Sim, S T Kim, N K D Kim, K Kim, W Park, J H Kim, K-T Jang, J Lee
PURPOSE: The KIT inhibitor, imatinib, has shown promising efficacy in patients with KIT-mutated melanoma; however, acquisition of resistance to imatinib occurs rapidly in the majority of patients. The mechanisms of acquired resistance to imatinib in melanoma remain unclear. METHODS: We analyzed biopsy samples from paired baseline and post-treatment tumor lesions in one patient with KIT-mutated melanoma who had had an initial objective tumor regression in response to imatinib treatment followed by disease progression 8 months later...
April 18, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28409323/differences-in-subtype-distribution-between-screen-detected-and-symptomatic-invasive-breast-cancer-and-their-impact-on-survival
#3
N Kobayashi, M Hikichi, K Ushimado, A Sugioka, Y Kiriyama, M Kuroda, T Utsumi
PURPOSE: Stage shift is considered a major reason for more favorable outcomes in patients with screen-detected breast cancer. However, even after adjusting for clinical stage, unresolved issues concerning the reasons for a survival benefit associated with screening programs remain. This study aims to evaluate differences in subtype distribution and outcomes among patients with screen-detected and symptomatic invasive breast cancer and assess whether variations in subtype distribution could explain differences in prognosis...
April 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28409322/tyrosine-kinase-inhibitors-reprogramming-immunity-in-renal-cell-carcinoma-rethinking-cancer-immunotherapy
#4
REVIEW
L M A Aparicio, I P Fernandez, J Cassinello
The immune system regulates angiogenesis in cancer by way of both pro- and antiangiogenic activities. A bidirectional link between angiogenesis and the immune system has been clearly demonstrated. Most antiangiogenic molecules do not inhibit only VEGF signaling pathways but also other pathways which may affect immune system. Understanding of the role of these pathways in the regulation of immunosuppressive mechanisms by way of specific inhibitors is growing. Renal cell carcinoma (RCC) is an immunogenic tumor in which angiogenesis and immunosuppression work hand in hand, and its growth is associated with impaired antitumor immunity...
April 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28397066/microrna-9-promotes-the-proliferation-migration-and-invasion-of-breast-cancer-cells-via-down-regulating-foxo1
#5
D-Z Liu, B Chang, X-D Li, Q-H Zhang, Y-H Zou
PURPOSE: The objective of the study was to investigate the role of microRNA-9 (miR-9) targeting forkhead box O1 (FOXO1) in the proliferation, migration, and invasion of breast cancer cells. METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to determine the expressions of miR-9 and FOXO1 mRNA in breast cancer tissues, normal breast tissues, breast cancer cell lines, and normal breast epithelial cells. After the up-regulation of miR-9 expression, qRT-PCR and Western blotting were used to determine the expression of FOXO1...
April 10, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28389881/influence-of-incidental-radiation-dose-in-the-subventricular-zone-on-survival-in-patients-with-glioblastoma-multiforme-treated-with-surgery-radiotherapy-and-temozolomide
#6
P Foro Arnalot, O Pera, N Rodriguez, X Sanz, A Reig, I Membrive, A Ortiz, R Granados, M Algara
PURPOSE: To determine if there is an association between the incidental radiation dose to the subventricular zone and survival in patients with glioblastoma multiforme treated with surgery, radiotherapy and temozolomide. METHODS AND MATERIALS: Sixty-five patients, treated between 2006 and 2015, were included in this retrospective study. The doses (75th percentile; p75) administered to the ipsilateral, contralateral and bilateral subventricular zone were compared to overall survival and progression-free survival using Cox proportional hazards models...
April 7, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28374321/reduced-late-urinary-toxicity-with-high-dose-intensity-modulated-radiotherapy-using-intra-prostate-fiducial-markers-for-localized-prostate-cancer
#7
A Zapatero, M Roch, D Büchser, P Castro, L Fernández-Banda, G Pozo, O Liñán, C Martin de Vidales, A Cruz-Conde, F García-Vicente
BACKGROUND/PURPOSE: To evaluate the impact of intensity-modulated radiotherapy (IMRT) with intra-prostate fiducial markers image-guided radiotherapy (IGRT) on the incidence of late urinary toxicity compared to 3D conformal radiotherapy (3DCRT) for patients with prostate cancer (PC). METHODS AND MATERIALS: We selected 733 consecutive patients with localized PC treated with dose-escalation radiotherapy between 2001 and 2014. Eligibility criteria were radiation dose >72...
April 3, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28374320/mesenchymal-circulating-tumor-cells-ctcs-and-oct4-mrna-expression-in-ctcs-for-prognosis-prediction-in-patients-with-non-small-cell-lung-cancer
#8
S Li, Q Chen, H Li, Y Wu, J Feng, Y Yan
PURPOSE: Circulating tumor cells (CTCs) with epithelial-to-mesenchymal transition (EMT) phenotypes might be related to tumor progression while OCT4 expression is involved in tumor metastasis and poor prognosis. But the possible clinical significance of EMT phenotypes of CTCs from non-small-cell lung cancer (NSCLC) patients has still to be demonstrated. Furthermore, none has been investigated the expression of OCT4 in CTCs. We therefore identified the EMT phenotype-based subsets of CTCs and determined the OCT4 expression status of CTCs in NSCLC patients, to explore their possible clinical relevance...
April 3, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28361329/implementation-of-safeguards-to-improve-patient-safety-in-chemotherapy
#9
M J Huertas-Fernández, Mª J Martínez-Bautista, M E Rodríguez-Mateos, M Zarzuela-Ramírez, T Muñoz-Lucero, J M Baena-Cañada
PURPOSE: To evaluate the effectiveness of safeguards introduced in the process of using cytostatic agents for increasing the safety of oncology patients. METHODS: Prospective hospital study conducted in two stages, before and after the implementation of safeguards: staff training, standardized procedures, computerized prescription, pharmaceutical validation, implementation of bar codes, and a new manual on drug interactions. Medication errors (MEs) were actively recorded during the process of administering chemotherapy in the Medical Oncology Department...
March 30, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28357633/the-tnm-8-m1b-and-m1c-classification-for-non-small-cell-lung-cancer-in-a-cohort-of-patients-with-brain-metastases
#10
C Nieder, M Hintz, O Oehlke, A Bilger, A L Grosu
BACKGROUND AND PURPOSE: According to the recent TNM 8 classification, patients with metastatic non-small cell lung cancer (NSCLC) and single extrathoracic metastasis should be classified as stage M1b, while those with 2 or more metastases comprise stage M1c. The purpose of this study was to analyze the impact of this classification in patients with brain metastases. MATERIALS AND METHODS: This retrospective study included 172 patients treated with individualized approaches...
March 29, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28357632/radiotherapy-for-adrenal-gland-metastases-from-hepatocellular-carcinoma
#11
B-Y Yuan, Y Hu, L Zhang, Y-H Chen, Y-Y Dong, Z-C Zeng
BACKGROUND: Several studies have found benefits of radiotherapy for adrenal metastasis from hepatocellular carcinoma (HCC). However, the efficacy, safety and outcome issues have not yet been fully addressed. Therefore, we performed this study to further elucidate the feasibility and outcome of radiotherapy in treating adrenal metastasis from HCC. METHODS: We retrospectively analyzed 81 patients with adrenal metastasis from HCC between 2001 and 2015. Eighteen patients received helical tomotherapy and 63 patients received conventional radiotherapy, including two-dimensional (2-D) or three-dimensional conformal radiotherapy (3-D CRT)...
March 29, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28357631/role-of-tim-3-in-ovarian-cancer
#12
REVIEW
Y Xu, H Zhang, Y Huang, X Rui, F Zheng
Evidences have suggested that immunotherapy for ovarian cancer is effective. Immune checkpoints have emerged in the field of cancer immunotherapy. Multiple studies have shown negative regulation of TIM-3 expression on CD4(+) and CD8(+) T cells and other immunocytes. Overexpression of TIM-3 in innate immune cells has been found in certain types of tumor. The blockade of TIM-3 leads to sustained anti-tumor reactions. TIM-3 plays an inhibitive role for immunity in ovarian cancer. TIM-3 is involved in the development of various subtypes of ovarian cancer and thus has the potential to be a therapeutic target for treatment of ovarian cancer...
March 29, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28353006/efficacy-and-cost-effectiveness-of-second-line-chemotherapy-in-elderly-patients-with-advanced-gastric-cancer
#13
K Zhou, F Wen, P Zhang, J Zhou, H Chen, H Zheng, Y Yang, Q Li
PURPOSE: Second-line chemotherapy has been shown to benefit patients with advanced gastric cancer (AGC), extending the overall survival (OS) and progression-free survival (PFS). This study aimed to assess the efficacy and cost-effectiveness of second-line treatment for elderly patients with AGC. METHODS: Medical records and follow-up information of elderly patients (≥70 years) with AGC who received second-line chemotherapy were collected. A Markov model comprising three health states PFS, progressive disease and death was developed to simulate the process of AGC...
March 28, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28353005/management-and-outcome-of-children-with-neuroendocrine-tumors-of-the-appendix-in-spain-is-there-room-for-improvement
#14
P Pérez-Albert, T de Rojas, M Á Lendínez, L Illade, M García-Abos, J Alonso-Cadenas, M Andión, L Madero
PURPOSE: Neuroendocrine tumors (NETs) are, after lymphomas, the most frequent gastrointestinal tumors in children, mainly located in the appendix. Best management remains unclear, given the absence of pediatric guidelines. We present the first Spanish series of pediatric patients with NETs. PATIENTS AND METHODS: Retrospective study of all pediatric patients (<18 years) with NET treated in four oncology reference institutions in Spain between 1994 and 2015. RESULTS: Seventeen patients were included...
March 28, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28342058/galician-consensus-on-management-of-cardiotoxicity-in-breast-cancer-risk-factors-prevention-and-early-intervention
#15
J F Cueva, S Antolín, L Calvo, I Fernández, M Ramos, L de Paz, J G Mata, R López, M Constenla, E Pérez, A González, M L Pellón, S Varela, T López
This Galician consensus statement is a joint oncologists/cardiologists initiative indented to establish basic recommendations on how to prevent and to manage the cardiotoxicity in breast cancer with the aim of ensuring an optimal cardiovascular care of these patients. A clinical screening of the patients before treatment is recommended to stratify them into a determined risk group based on their intrinsic cardiovascular risk factors and those extrinsic arose from breast cancer therapy, thereby providing individualized preventive and monitoring measures...
March 24, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28332091/significance-of-mnk1-in-prognostic-prediction-and-chemotherapy-development-of-epithelial-ovarian-cancer
#16
S Hou, P Du, P Wang, C Wang, P Liu, H Liu
BACKGROUND: Ovarian cancer is the most lethal gynecologic malignancy worldwide with surgery as the only curative treatment. Long-term overall survival (OS) of ovarian cancer is far from satisfactory, even though significant improvement has been made in post-operative chemotherapy. One of the most important death cause is the chemoresistance due to consecutive chemotherapy. Therefore, understanding the molecular mechanisms involved in ovarian cancer development and identification of novel therapeutic targets are urgently required...
March 22, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28315180/inflammation-based-indexes-and-clinicopathologic-features-are-strong-predictive-values-of-preoperative-circulating-tumor-cell-detection-in-gastric-cancer-patients
#17
L Zheng, K Zou, C Yang, F Chen, T Guo, B Xiong
PURPOSE: Circulating tumor cell (CTC) count and the host inflammatory response are two independent predictors for patients with various malignant disease. Several inflammation-based indicators have been demonstrated to have prognostic value in many malignant solid tumors, including systemic immune-inflammation index (SII), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and prognostic nutrition index (PNI). The aim of this study was to evaluate the predictive value of the inflammation-based indexes including SII, NLR PLR, and PNI for CTC detection of gastric cancer patients before surgery...
March 17, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28299581/expression-of-anoctamin-1-is-associated-with-advanced-tumor-stage-in-patients-with-non-small-cell-lung-cancer-and-predicts-recurrence-after-surgery
#18
Y He, H Li, Y Chen, P Li, L Gao, Y Zheng, Y Sun, J Chen, X Qian
PURPOSE: Anoctamin 1 (ANO1), a recently identified calcium-activated chloride channel, has been found to have a critical role in tumorigenesis and tumor progression in several types of cancer. However, its role in non-small cell lung cancer (NSCLC) remains to be elucidated. In this study, we evaluated the utility of ANO1 as a prognostic marker. PATIENTS AND METHODS: ANO1 expression was detected in tumor tissues and paraneoplastic tissues of I-IV stage NSCLC patients who received surgical treatment by using immunohistochemical and quantitative RT-PCR analyses...
March 15, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28299580/the-expression-of-hdac7-in-cancerous-gastric-tissues-is-positively-associated-with-distant-metastasis-and-poor-patient-prognosis
#19
Y Yu, F Cao, X Yu, P Zhou, Q Di, J Lei, Y Tai, H Wu, X Li, X Wang, W Zhang, P Li, Y Li
PURPOSE: To characterize the expression patterns of HDAC7 in patients with gastric cancer and evaluate the prognostic value of HDAC7 in gastric cancer. METHODS: The expression of histone deacetylase 7 (HDAC7) was detected in paraffin-embedded gastric cancer samples from 86 patients by immunohistochemistry, and the differences in the expression of HDAC7 between cancerous and corresponding adjacent noncancerous tissues were compared using the Wilcoxon matched-pairs signed rank test...
March 15, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28299579/erratum-to-procedures-and-recommended-times-in-the-care-process-of-the-patient-with-pancreatic-cancer-pan-time-consensus-between-scientific-societies
#20
R Vera, A Ferrández, C J Ferrer, C Flores, C Joaquín, S López, T Martín, E Martín, M Marzo, A Sarrión, E Vaquero, A Zapatero, J Aparicio
No abstract text is available yet for this article.
March 15, 2017: Clinical & Translational Oncology
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