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Clinical & Translational Oncology

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https://www.readbyqxmd.com/read/28332091/significance-of-mnk1-in-prognostic-prediction-and-chemotherapy-development-of-epithelial-ovarian-cancer
#1
S Hou, P Du, P Wang, C Wang, P Liu, H Liu
BACKGROUND: Ovarian cancer is the most lethal gynecologic malignancy worldwide with surgery as the only curative treatment. Long-term overall survival (OS) of ovarian cancer is far from satisfactory, even though significant improvement has been made in post-operative chemotherapy. One of the most important death cause is the chemoresistance due to consecutive chemotherapy. Therefore, understanding the molecular mechanisms involved in ovarian cancer development and identification of novel therapeutic targets are urgently required...
March 22, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28315180/inflammation-based-indexes-and-clinicopathologic-features-are-strong-predictive-values-of-preoperative-circulating-tumor-cell-detection-in-gastric-cancer-patients
#2
L Zheng, K Zou, C Yang, F Chen, T Guo, B Xiong
PURPOSE: Circulating tumor cell (CTC) count and the host inflammatory response are two independent predictors for patients with various malignant disease. Several inflammation-based indicators have been demonstrated to have prognostic value in many malignant solid tumors, including systemic immune-inflammation index (SII), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and prognostic nutrition index (PNI). The aim of this study was to evaluate the predictive value of the inflammation-based indexes including SII, NLR PLR, and PNI for CTC detection of gastric cancer patients before surgery...
March 17, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28299581/expression-of-anoctamin-1-is-associated-with-advanced-tumor-stage-in-patients-with-non-small-cell-lung-cancer-and-predicts-recurrence-after-surgery
#3
Y He, H Li, Y Chen, P Li, L Gao, Y Zheng, Y Sun, J Chen, X Qian
PURPOSE: Anoctamin 1 (ANO1), a recently identified calcium-activated chloride channel, has been found to have a critical role in tumorigenesis and tumor progression in several types of cancer. However, its role in non-small cell lung cancer (NSCLC) remains to be elucidated. In this study, we evaluated the utility of ANO1 as a prognostic marker. PATIENTS AND METHODS: ANO1 expression was detected in tumor tissues and paraneoplastic tissues of I-IV stage NSCLC patients who received surgical treatment by using immunohistochemical and quantitative RT-PCR analyses...
March 15, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28299580/the-expression-of-hdac7-in-cancerous-gastric-tissues-is-positively-associated-with-distant-metastasis-and-poor-patient-prognosis
#4
Y Yu, F Cao, X Yu, P Zhou, Q Di, J Lei, Y Tai, H Wu, X Li, X Wang, W Zhang, P Li, Y Li
PURPOSE: To characterize the expression patterns of HDAC7 in patients with gastric cancer and evaluate the prognostic value of HDAC7 in gastric cancer. METHODS: The expression of histone deacetylase 7 (HDAC7) was detected in paraffin-embedded gastric cancer samples from 86 patients by immunohistochemistry, and the differences in the expression of HDAC7 between cancerous and corresponding adjacent noncancerous tissues were compared using the Wilcoxon matched-pairs signed rank test...
March 15, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28299579/erratum-to-procedures-and-recommended-times-in-the-care-process-of-the-patient-with-pancreatic-cancer-pan-time-consensus-between-scientific-societies
#5
R Vera, A Ferrández, C J Ferrer, C Flores, C Joaquín, S López, T Martín, E Martín, M Marzo, A Sarrión, E Vaquero, A Zapatero, J Aparicio
No abstract text is available yet for this article.
March 15, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28289961/the-time-has-come-for-new-models-in-febrile-neutropenia-a-practical-demonstration-of-the-inadequacy-of-the-mascc-score
#6
A Carmona-Bayonas, P Jiménez-Fonseca, J Virizuela Echaburu, M Sánchez Cánovas, F Ayala de la Peña
Since its publication more than 15 years ago, the MASCC score has been internationally validated any number of times and recommended by most clinical practice guidelines for the management of febrile neutropenia (FN) around the world. We have used an empirical data-supported simulated scenario to demonstrate that, despite everything, the MASCC score is impractical as a basis for decision-making. A detailed analysis of reasons supporting the clinical irrelevance of this model is performed. First, seven of its eight variables are "innocent bystanders" that contribute little to selecting low-risk candidates for ambulatory management...
March 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28281084/the-role-and-clinical-implications-of-the-endosteal-niche-and-osteoblasts-in-regulating-leukemia
#7
REVIEW
S Azizidoost, V Vijay, C R Cogle, E Khodadi, N Saki
Osteoblasts are one among the critical components of the endosteal bone marrow (BM) niche. In addition to hematopoietic stem cell fate, their role in leukemogenesis as well as metastasis of a variety of cancers has been demonstrated in various studies. In this regard, endosteal niche can have a dual role as an initiator and protective role against leukemia. Knowledge of growth factors, chemokines and cytokines secreted by osteoblasts as well as their interaction with signaling pathways inform our understanding of the development, prognosis, recurrence and treatment of malignant BM diseases...
March 9, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28271337/micrornas-as-prognostic-biomarker-and-relapse-indicator-in-leukemia
#8
REVIEW
S Hajizamani, M Shahjahani, S Shahrabi, N Saki
Despite significant progress in the treatment of different types of leukemia, relapse remains a challenging clinical problem that is observed in a number of patients who are often resistant to chemotherapy and exhibit multi-drug resistance. Identification of new functional biomarkers, including microRNAs, is essential to determine prognosis and relapse at the time of diagnosis. The aim of this study was to detect the specific microRNAs involved in predicting relapse or progression in acute and chronic leukemias, as well as their relationship with overall survival (OS) and relapse-free survival (RFS)...
March 7, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28258492/sox10-is-over-expressed-in-bladder-cancer-and-contributes-to-the-malignant-bladder-cancer-cell-behaviors
#9
H Yin, C Qin, Y Zhao, Y Du, Z Sheng, Q Wang, Q Song, L Chen, C Liu, T Xu
PURPOSE: To detect the expression level and significance of SOX10 in human bladder cancer. METHODS: Immunohistochemical analyses were performed to assess SOX10 protein level using a bladder cancer tissue microarray (including 59 spots of cancer tissues and 46 spots of paired normal tissues) and 31 specimens and to define the relationship between SOX10 and clinicopathological bladder cancer characteristics in patients. SOX10 protein and mRNA levels in bladder cancer cell lines (T24, 5637, BIU87, EJ) and transitional cell papilloma cell line (RT4) were tested by western blotting and quantitative real-time PCR (q-PCR), respectively...
March 3, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28258491/stimulated-thyroglobulin-values-above-5-6%C3%A2-ng-ml-before-radioactive-iodine-ablation-treatment-following-levothyroxine-withdrawal-is-associated-with-a-2-38-fold-risk-of-relapse-in-tg-ab-negative-subjects-with-differentiated-thyroid-cancer
#10
U Mousa, A S Yilmaz, A Nar
BACKGROUND: Serum thyroglobulin (Tg) is the key parameter used in the follow-up of subjects with differentiated thyroid cancer (DTC). Current guidelines advise its measurement to take place when Thyrotropin (TSH) levels are >30 µU/ml (stimulated Tg) and when TSH < 0.1 µU/ml (suppressed Tg). Although stimulated Tg levels <1 ng/ml have been shown to display excellent prognosis, relapses may occur despite low Tg levels. Recently, very low cut-off levels of stimulated Tg have been proposed for determining the recurrence risk in these subjects...
March 3, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28255650/diffuse-low-grade-glioma-a-review-on-the-new-molecular-classification-natural-history-and-current-management-strategies
#11
REVIEW
P D Delgado-López, E M Corrales-García, J Martino, E Lastra-Aras, M T Dueñas-Polo
The management of diffuse supratentorial WHO grade II glioma remains a challenge because of the infiltrative nature of the tumor, which precludes curative therapy after total or even supratotal resection. When possible, functional-guided resection is the preferred initial treatment. Total and subtotal resections correlate with increased overall survival. High-risk patients (age >40, partial resection), especially IDH-mutated and 1p19q-codeleted oligodendroglial lesions, benefit from surgery plus adjuvant chemoradiation...
March 2, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28255649/the-potential-role-of-brachytherapy-in-the-irradiation-of-patients-with-lung-cancer-a-systematic-review
#12
REVIEW
A Youroukou, I Gkiozos, Z Kalaitzi, I Tsalafoutas, K Papalla, A Charpidou, V Kouloulias
To review the use of brachytherapy as an adjuvant therapy to reduce recurrences after sublobar resections and as a palliation to patients with inoperable disease. Α review of all published studies was performed to identify the recurrence rate after brachytherapy adjuvant to sublobar resection and assess the palliation of symptoms and the complications of brachytherapy as a palliative treatment. Most of the studies that we found about brachytherapy as an adjuvant therapy to sublobar resection due to patient's poor cardiopulmonary reserve showed that brachytherapy offered low recurrence rate with low toxicity...
March 2, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28251497/why-do-patients-with-thick-melanoma-have-different-outcomes-a-retrospective-epidemiological-and-survival-analysis
#13
LETTER
E Rodríguez-Lomba, I Marquez-Rodas, E Mercader-Cidoncha, R Suárez-Fernández, J A Avilés-Izquierdo
No abstract text is available yet for this article.
March 1, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28251496/brg1-regulation-by-mir-155-in-human-leukemia-and-lymphoma-cell-lines
#14
M Cuadros, V Sánchez-Martín, A Herrera, C Baliñas, J Martín-Padrón, L Boyero, P Peinado, P P Medina
INTRODUCTION/PURPOSE: BRG1 is a key regulator of leukemia stem cells. Indeed, it has been observed that this type of cells is unable to divide, survive and develop new tumors when BRG1 is down-regulated. MATERIALS AND METHODS: We assessed BRG1 and miR-155 expression in 23 leukemia cell lines, and two no pathological lymphocyte samples using qPCR. MiR-155 transfection and western blot were used to analyze the relationship between miR-155 and its validated target, BRG1, by measuring protein expression levels...
March 1, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28247194/association-of-neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-with-er-and-pr-in-breast-cancer-patients-and-their-changes-after-neoadjuvant-chemotherapy
#15
J Xu, C Ni, C Ma, L Zhang, X Jing, C Li, Y Liu, X Qu
PURPOSE: Proinflammatory markers, including neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR), are associated with many aspects of different malignancies. The aim of this study was to assess the associations of NLR and PLR with estrogen receptor (ER) and progesterone receptor (PR) expression in locally advanced breast cancer patients and their changes after neoadjuvant chemotherapy (NAC). Whether these parameters were predictive for the response to NAC in breast cancer patients was also evaluated...
February 28, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28243990/associations-between-single-nucleotide-polymorphisms-and-inflammatory-bowel-disease-associated-colorectal-cancers-in-inflammatory-bowel-disease-patients-a-meta-analysis
#16
REVIEW
H Li, Z Jin, X Li, L Wu, J Jin
PURPOSE: To assess the correlation between single-nucleotide polymorphisms (SNPs) and inflammatory bowel disease (IBD)-associated colorectal cancer (CRC) in IBD patients. METHODS: A systematic search of PubMed, EmBase, and Cochrane databases was performed. Five genetic models (allelic, dominant, recessive, heterozygous and homozygous models) were used to analyze the associations, and trial sequential analysis was used to analyze the robustness of the results. RESULTS: We collected and analyzed the results of seven trials including a total of 2287 patients in our meta-analysis...
February 27, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28243989/erratum-to-equity-barriers-and-cancer-disparities-study-of-the-spanish-society-of-medical-oncology-on-the-access-to-oncologic-drugs-in-the-spanish-regions
#17
J Salvador, J Aparicio, F J Baron, R García-Campelo, R Garcia-Carbonero, P Lianes, A Llombart, D Isla, J M Piera, M Muñoz, J Puente, F Rivera, C A Rodríguez, J A Virizuela, M Martín, P Garrido
No abstract text is available yet for this article.
February 27, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28243988/fotrocan-delphi-consensus-statement-regarding-the-prevention-and-treatment-of-cancer-associated-thrombosis-in-areas-of-uncertainty-and-low-quality-of-evidence
#18
P Jimenez-Fonseca, A Carmona-Bayonas, C Calderon, J Fontcuberta Boj, C Font, R Lecumberri, M Monreal, A J Muñoz Martín, R Otero, A Rubio, P Ruiz-Artacho, C Suarez Fernández, E Colome, P Pérez Segura
INTRODUCTION: Decision-making in cancer-related venous thromboembolism (VTE) is often founded on scant lines of evidence and weak recommendations. The aim of this work is to evaluate the percentage of agreement surrounding a series of statements about complex, clinically relevant, and highly uncertain aspects to formulate explicit action guidelines. MATERIALS AND METHODS: Opinions were based on a structured questionnaire with appropriate scores and were agreed upon using a Delphi method...
February 27, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28224267/selection-of-dna-aptamers-for-extra-cellular-domain-of-human-epidermal-growth-factor-receptor-2-to-detect-her2-positive-carcinomas
#19
A Sett, B B Borthakur, U Bora
BACKGROUND: Human epidermal growth factor receptor 2 (Her2, an orphan receptor of ErbB family) is considered as an important biomarker as it plays a key role in the development and progression of aggressive types of breast, ovarian, stomach and gastric cancer. In the present study, we developed novel DNA aptamers against the extra-cellular domain (ECD) of Her2 protein for detection of Her2-positive carcinomas. METHODS: We cloned and expressed Her2-ECD protein in E...
February 21, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28205126/estimation-of-diagnosis-and-prognosis-in-et-by-assessment-of-calr-and-jak2-v617f-mutations-and-laboratory-findings-a-meta-analysis
#20
REVIEW
N Saki, R Shirzad, F Rahim, A Saki Malehi
BACKGROUND: Essential thrombocythemia (ET) is a benign disease with slow progress in which thrombosis is a cause of mortality. JAK2(V617F) and calreticulin (CALR) are the most frequent mutations in this disease. In this systematic review and meta-analysis, we compared the prevalence of JAK2(V617F) and CALR mutations in ET and examined the incidence of thrombosis and other hematologic indices. METHODS: After choosing MeSH keywords, including essential thrombocythemia, JAK2(V617F), calreticulin, prognosis, and diagnosis, as well as searching Medline/PubMed and Scopus, 12 papers were selected...
February 15, 2017: Clinical & Translational Oncology
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