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Clinical & Translational Oncology

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https://www.readbyqxmd.com/read/28205126/estimation-of-diagnosis-and-prognosis-in-et-by-assessment-of-calr-and-jak2-v617f-mutations-and-laboratory-findings-a-meta-analysis
#1
REVIEW
N Saki, R Shirzad, F Rahim, A Saki Malehi
BACKGROUND: Essential thrombocythemia (ET) is a benign disease with slow progress in which thrombosis is a cause of mortality. JAK2(V617F) and calreticulin (CALR) are the most frequent mutations in this disease. In this systematic review and meta-analysis, we compared the prevalence of JAK2(V617F) and CALR mutations in ET and examined the incidence of thrombosis and other hematologic indices. METHODS: After choosing MeSH keywords, including essential thrombocythemia, JAK2(V617F), calreticulin, prognosis, and diagnosis, as well as searching Medline/PubMed and Scopus, 12 papers were selected...
February 15, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28194687/fecal-incontinence-and-radiation-dose-on-anal-sphincter-in-patients-with-locally-advanced-rectal-cancer-larc-treated-with-preoperative-chemoradiotherapy-a-retrospective-single-institutional-study
#2
F Arias, C Eito, G Asín, I Mora, K Cambra, F Mañeru, B Ibáñez, L Arbea, A Viudez, I Hernández, J I Arrarás, M Errasti, M Barrado, M Campo, I Visus, S Flamarique, M A Ciga
BACKGROUND: The objective of the study is to determine the correlations among the variables of dose and the sphincter function (SF) in patients with locally advanced rectal cancer treated with preoperative capecitabine/radiotherapy followed by low anterior resection (LAR) + TME. METHODS: We retrospectively reviewed 92 consecutive patients with LARC treated at our center with LAR from 2006 and more than 2 years free from disease. We re-contoured the anal sphincters (AS) of patients with the help of the radiologist...
February 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28188489/effects-of-low-dose-radiation-on-adaptive-response-in-colon-cancer-stem-cells
#3
X Zhao, J-W Cui, J-H Hu, S-J Gao, X-L Liu
PURPOSE: Biological effects of low-dose radiation (LDR) are distinguishable from those of high-dose radiation. Adaptive response is an important biological effect following low-dose radiation. Cancer stem cells (CSCs) have self-renewal and multidirectional differentiation potency which results in relapse and metastasis of cancer. In this study, we aimed to examine whether adaptive response could be induced in CSCs by LDR. METHODS: Parental cells of three colon cancer cell lines (HRT18, HT29, and HCT116) and CSCs of these three cell lines were irradiated with LDR (i...
February 10, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28188488/long-noncoding-rnas-as-novel-serum-biomarkers-for-the-diagnosis-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#4
C Zheng, H Hao, L Chen, J Shao
PURPOSE: Long noncoding RNAs (lncRNAs) are outstanding as novel cancer biomarkers with great prospects. Herein, we focused on summarizing the overall diagnostic evaluation of lncRNAs for hepatocellular carcinoma (HCC). METHODS: Relevant literature was collected from the online databases. The Quality Assessment for Studies of Diagnostic Accuracy checklist was used to assess the quality of included studies. The pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were plotted using random-effects models...
February 10, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28181176/circulating-levels-of-autoantibodies-against-l1-cell-adhesion-molecule-as-a-potential-diagnostic-biomarker-in-esophageal-squamous-cell-carcinoma
#5
Y-W Xu, Y-H Peng, L-Q Ran, T-T Zhai, H-P Guo, S-Q Qiu, H-L Chen, Z-Y Wu, E-M Li, J-J Xie
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a common malignant disease worldwide, especially in China. We aimed to determine the level of autoantibodies against L1CAM in patients with ESCC. METHODS: Levels of circulating autoantibodies against L1CAM antigens were determined by an enzyme-linked immunosorbent assay in cohort 1 (191 patients with ESCC and 94 normal controls) and validated in cohort 2 (47 patients with ESCC and 47 normal controls). Receiver-operating characteristics were employed to calculate diagnostic accuracy...
February 8, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28168600/the-role-of-pancreatic-cancer-derived-exosomes-in-cancer-progress-and-their-potential-application-as-biomarkers
#6
REVIEW
H Jin, Y Wu, X Tan
Pancreatic cancer is one of the most deadly cancers, with dismal prognosis due to its poor early detection rate and high metastatic rate. Thus, elucidation of the molecular mechanisms accounting for its metastasis and discovery of competent biomarkers is required. Exosomes are multivesicular body-derived small extracellular vesicles released by various cell types that serve as important message carriers during intercellular communication. They are also known to play critical roles during cancer-genesis, cancer-related immune reactions, and metastasis...
February 6, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28160206/distribution-of-tumor-stage-and-initial-treatment-modality-in-patients-with-primary-hepatocellular-carcinoma
#7
X Xiang, J-H Zhong, Y-Y Wang, X-M You, L Ma, B-D Xiang, L-Q Li
OBJECTIVE: This study reviewed the distribution of each tumor stage and each type of initial treatment modality among patients with primary hepatocellular carcinoma (HCC) treated at a tertiary tumor hospital between January 2003 and October 2013. METHODS: Baseline data of patients with primary hepatocellular carcinoma treated between January 2003 and October 2013 were retrospectively collected. Tumor stage was determined according to the Barcelona Clinic Liver Cancer (BCLC) staging system and Hong Kong Clinic Liver Cancer (HKLC) staging system...
February 3, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28150169/kras-genetic-variant-as-a-prognostic-factor-for-recurrence-in-resectable-non-small-cell-lung-cancer
#8
I Sullivan, J Salazar, C Arqueros, M Andrés, A Sebio, M Majem, J Szafranska, E Martínez, D Páez, A López-Pousa, M Baiget, A Barnadas
PURPOSE: Several angiogenic prognostic markers are under investigation because of their potential clinical utility, aiming to improve patient outcomes. We hypothesized that genetic variant in the VEGF pathway could be used as prognostic markers of survival in non-small cell lung cancer (NSCLC) patients undergoing pulmonary resection. METHODS: We evaluated the relationship between genetic variants in the VEGF pathway and relapse-free survival (RFS, main endpoint) and overall survival (OS, secondary endpoint) among 131 patients with stage I-III NSCLC treated with surgical resection from 2009 to 2013...
February 1, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28150168/retroperitoneal-lymph-node-dissection-an-update-in-testicular-malignancies
#9
REVIEW
K Yadav
Management of testicular cancer has evolved through many breakthroughs. The decades of zeal to improve oncologic adequacy and to decrease morbidity has led to the current scientific knowledge of retroperitoneal lymph node dissection templates. Retroperitoneal lymph node dissection (RPLND) has potential for staging, prognostication and therapeutic importance in the management of testicular malignancy. RPLND has overcome limitations of current imaging which understage 30% of stage I disease and overstage 25-30% of stage II disease...
February 1, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28144828/physiological-expression-of-pancreatic-somatostatin-receptors-in-99mtc-hynic-toc-scintigraphy
#10
L de la Cueva, P Lloro, M J Sangrós, L López Vélez, P Navarro, L Sarria, S Álvarez, D Abós
PURPOSE: To describe the frequency of head and/or pancreas uncinate process uptake of 99mTc-HYNIC-TOC, to study its nature, and analyze its diagnostic value. MATERIALS AND METHODS: Retrospective evaluation of 47 consecutive 99mTc-HYNIC-TOC examinations was conducted. Head and/or pancreas uncinate process uptake was considered to be physiological in patients with normal CT at the same episode and in follow-up. It was analyzed if age or diabetes mellitus was justifying the existence or not of uptake...
January 31, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28138952/erratum-to-gastrointestinal-stromal-tumors-gists-seap-seom-consensus-on-pathologic-and-molecular-diagnosis
#11
J Martin-Broto, V Martinez-Marín, C Serrano, N Hindi, J A López-Guerrero, M Biscuola, R Ramos-Asensio, A Vallejo-Benítez, D Marcilla-Plaza, R González-Cámpora
No abstract text is available yet for this article.
January 30, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28130707/topography-of-the-sentinel-node-according-to-the-affected-lobe-in-lung-cancer
#12
J M Galbis-Caravajal, A Lafuente-Sanchis, M Estors-Guerrero, N Martinez-Hernández, C Fuster-Diana, A Cremades, Á Zúñiga
PURPOSE: The objective of this study is to describe the anatomic location of the sentinel lymph node (SLN) of patients with lung carcinoma and to analyze its relationship with the characteristics of the tumor. PATIENTS AND METHODS: 98 Stage I lung cancer patients were included in the study. SLN was marked just after performing the thoracotomy by injecting peritumorally 0.25 mCi of nanocolloid of albumin (Nanocol1) labeled with Tc-99 m in 0.3 ml, and later, it was resected...
January 27, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28127669/neuron-specific-enolase-and-response-to-initial-therapy-are-important-prognostic-factors-in-patients-with-small-cell-lung-cancer
#13
M Zhou, Z Wang, Y Yao, H Zhou, M Liu, J Sun
PURPOSE: The prognostic factors for the survival of small cell lung cancer (SCLC) patients are still widely debated. The aim of this study was to identify the clinical features and prognostic factors in SCLC patients. METHODS: A retrospective study was conducted on SCLC patients who were treated in our hospital between July 2010 and July 2015. Comparison of overall survival (OS) was performed using the Kaplan-Meier method. Prognostic factors for OS were identified by multivariate Cox regression models...
January 26, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28120325/predictive-factors-for-survival-in-neoadjuvant-radiochemotherapy-for-advanced-rectal-cancer
#14
A Reig Castillejo, I Membrive, P Foro, J Quera, X Sanz, N Rodriguez, E Fernández-Velilla, O Pera, A Ortiz, M Algara
INTRODUCTION: Neoadjuvant radiochemotherapy followed by radical surgery is the standard approach in advanced rectal carcinoma. Tumor response is determined in histological specimen. OBJECTIVE: To assess predictive factors for survival in 115 patients. PATIENTS AND METHOD: 115 patients treated with neoadjuvant radiochemotherapy followed by radical surgery with total mesorectal excision, in our hospital from January 2007 to December 2014. All patients received pelvic radiotherapy with concomitant chemotherapy, followed by radical surgery and in some adjuvant chemotherapy...
January 24, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28120324/activity-of-weekly-paclitaxel-cetuximab-chemotherapy-in-unselected-patients-with-recurrent-metastatic-head-and-neck-squamous-cell-carcinoma-prognostic-factors
#15
I Pajares Bernad, J Martínez Trufero, L Calera Urquizu, R A Pazo Cid, A Cebollero de Miguel, M J Agustin, M Lanzuela, A Antón
BACKGROUND: Standard treatment for recurrent/metastatic head and neck squamous cell carcinoma (RM-SCCHN) is based in on platinum and cetuximab combination therapy. Unfortunately, not all patients are candidates to receive platinum-based treatment, because of different conditions as comorbidity and poor performance status. Weekly paclitaxel and cetuximab (WPC) is an active therapeutic alternative, based on a phase II study, with less toxicity. Our main objective is to confirm its activity in unselected patients, mostly unfit for aggressive therapies, analysing also some clinically relevant prognostic factors (PFs)...
January 24, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28120323/nasopharyngeal-carcinoma-30-year-experience-of-a-single-institution-in-a-non-endemic-area
#16
J García-Lorenzo, N Farre, A Codina, O Gallego, M De Vega, X León
PURPOSE: Over the past years, radiotherapy techniques have changed significantly. The impact of these changes in the management of nasopharyngeal carcinoma (NPC) has not been fully evaluated. METHODS/PATIENTS: Between 1984 and 2014, 223 NPC were diagnosed in our hospital. Prior to 2000, patients were treated with 2D treatment plan (RT2D) that evolved to 3D schemes thereafter (RT3D). RESULTS: Tumors in the RT3D period showed significantly lower stages than those in the RT2D period...
January 24, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28105537/procedures-and-recommended-times-in-the-care-process-of-the-patient-with-pancreatic-cancer-pan-time-consensus-between-scientific-societies
#17
R Vera, A Ferrández, C J Ferrer, C Flores, C Joaquín, S López, T Martín, E Martín, M Marzo, A Sarrión, E Vaquero, A Zapatero, J Aparicio
PURPOSE: Pancreatic cancer (PC) is a disease with bad prognosis. It is usually diagnosed at advanced stages and its treatment is complex. The aim of this consensus document was to provide recommendations by experts that would ameliorate PC diagnosis, reduce the time to treatment, and optimize PC management by interdisciplinary teams. METHODS: As a consensus method, we followed the modified Delphi methodology. A scientific committee of experts provided 40 statements that were submitted in two rounds to a panel of 87 specialists of 12 scientific societies...
January 19, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28105536/a-long-noncoding-rna-uca1-promotes-proliferation-and-predicts-poor-prognosis-in-glioma
#18
W Zhao, C Sun, Z Cui
BACKGROUND: Acting as a proto-oncogene, long noncoding RNAs (lncRNAs) urothelial carcinoembryonic antigen 1 (UCA1) plays a key role in the occurrence and development of several human tumors. However, the expression and biological functions of UCA1 in glioma are less known. This study discussed the expression of UCA1 in glioma and its effect on the proliferation and cell cycle of glioma cells. METHOD: LncRNA UCA1 expressions in 64 glioma samples (Grade I-II in 22 cases and Grade III-IV in 42 cases, according to WHO criteria) and 10 normal brain samples were detected using real-time fluorescence quantitative PCR...
January 19, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28093702/rabies-virus-vaccine-as-an-immune-adjuvant-against-cancers-and-glioblastoma-new-studies-may-resurrect-a-neglected-potential
#19
REVIEW
M A Altinoz, S Guloksuz, I Elmaci
To review the literature about the use of Rabies Virus-Vaccine (RV-V) as an anticancer immunotherapeutic modality in the light of recent findings. The literature search in relevant databases with the following key words: Rabies virus, cancer, remission. Remissions occured following RV-V injections in patients with cervical cancer and melanoma. Pilot clinical studies showed that RV-V injections enhanced survival in glioblastoma patients, which is supported by findings in GL261 mouse glioma model. If public health studies demonstrate protective role of RV-V against certain types of cancers, it can be benefitted as a novel immune adjuvant in clinic...
January 16, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28093701/cancer-incidence-in-spain-2015
#20
J Galceran, A Ameijide, M Carulla, A Mateos, J R Quirós, D Rojas, A Alemán, A Torrella, M Chico, M Vicente, J M Díaz, N Larrañaga, R Marcos-Gragera, M J Sánchez, J Perucha, P Franch, C Navarro, E Ardanaz, J Bigorra, P Rodrigo, R Peris Bonet
PURPOSE: Periodic cancer incidence estimates of Spain from all existing population-based cancer registries at any given time are required. The objective of this study was to present the current situation of cancer incidence in Spain. METHODS: The Spanish Network of Cancer Registries (REDECAN) estimated the numbers of new cancer cases occurred in Spain in 2015 by applying the incidence-mortality ratios method. In the calculus, incidence data from population-based cancer registries and mortality data of all Spain were used...
January 16, 2017: Clinical & Translational Oncology
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