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Clinical & Translational Oncology

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https://www.readbyqxmd.com/read/29777377/radiolabeled-f-ab-2-cetuximab-for-theranostic-purposes-in-colorectal-and-skin-tumor-bearing-mice-models
#1
P-S Bellaye, M Moreau, O Raguin, A Oudot, C Bernhard, J-M Vrigneaud, L Dumont, D Vandroux, F Denat, A Cochet, F Brunotte, B Collin
PURPOSE: This study aimed to investigate theranostic strategies in colorectal and skin cancer based on fragments of cetuximab, an anti-EGFR mAb, labeled with radionuclide with imaging and therapeutic properties, 111 In and 177 Lu, respectively. METHODS: We designed F(ab')2 -fragments of cetuximab radiolabeled with 111 In and 177 Lu. 111 In-F(ab')2 -cetuximab tumor targeting and biodistribution were evaluated by SPECT in BalbC nude mice bearing primary colorectal tumors...
May 17, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29766457/influence-of-age-on-variation-in-patterns-of-care-in-patients-with-rectal-cancer-in-catalonia-spain
#2
R Vernet, J M Borras, L Aliste, M Antonio, A Guarga, P Manchon-Walsh
BACKGROUND: Population ageing is a relevant concern in people diagnosed with rectal cancer. This study evaluates the adherence to clinical practice guidelines (CPGs) and patient outcomes in rectal cancer, with a particular focus on variation according to age. METHODS: This is a multicentre retrospective cohort study of all patients surgically treated for the first time for primary rectal cancer with curative intent in public hospitals in Catalonia during two study periods: first, with data from 2005 to 2007, and then with data from 2011 to 2012...
May 15, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29766456/prognostic-role-for-the-derived-neutrophil-to-lymphocyte-ratio-in-early-breast-cancer-a-geicam-9906-substudy
#3
A J Templeton, Á Rodríguez-Lescure, A Ruíz, E Alba, L Calvo, M Ruíz-Borrego, A Santaballa, C A Rodríguez, C Crespo, M Ramos, J M Gracia-Marco, A Lluch, I Álvarez, M I Casas, M Sánchez-Aragó, R Caballero, E Carrasco, E Amir, M Martin, A Ocaña
PURPOSE: Elevated markers of host inflammation, a hallmark of cancer, have been associated with worse outcomes in several solid tumors. Here, we explore the prognostic role of the derived neutrophil-to-lymphocyte ratio (dNLR), across different tumor subtypes, in patients with early breast cancer. PATIENTS AND METHODS: This was a retrospective analysis of 1246 patients with lymph node-positive, operable early breast cancer enrolled in the GEICAM/9906 trial, a multicenter randomized phase 3 study evaluating adjuvant chemotherapy...
May 15, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29766455/consensus-document-on-the-progression-and-treatment-response-criteria-in-gastroenteropancreatic-neuroendocrine-tumors
#4
X Merino-Casabiel, J Aller, J Arbizu, R García-Figueiras, C González, E Grande, P Jiménez-Fonseca, M I Sevilla, J Capdevila
PURPOSE: Gastroenteropancreatic neuroendocrine tumors are a heterogeneous group of low incidence neoplasms characterized by a low proliferative activity and slow growth. Their response to targeted therapies is heterogeneous and often does not lead to tumor shrinkage. Thus, evaluation of the therapeutic response should differ from other kind of tumors. METHODS: To answer relevant questions about which techniques are best in the assessment of progression or treatment response a RAND/UCLA-based consensus process was implemented...
May 15, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29761266/evaluation-of-thyroid-gland-as-an-organ-at-risk-after-breast-cancer-radiotherapy-a-systematic-review-and-meta-analysis
#5
REVIEW
L Darvish, M Ghorbani, S Hosseini Teshnizi, N Roozbeh, F Seif, M Reza Bayatiani, C Knaup, A Amraee
BACKGROUND: Radiotherapy can often lead to thyroid dysfunction. Some studies demonstrated that treatment of breast cancer by RT can expose thyroid gland to high doses of radiation. The aim of this systematic review is to evaluate consideration of thyroid gland as an organ at risk. METHODS: In this systematic review and meta-analysis to select initial studies, a comprehensive search by two independent reviewers was performed. Electronical databases following: Web of Science, Google Scholar, Scopus, PubMed, Elsevier, Embase, ProQuest and Persian databases such as Iranmedex, Magiran, and SID were searched...
May 14, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29744734/prognostic-factors-for-relapse-in-stage-i-testicular-seminoma-tumor-size-and-rete-testis-invasion-revisited
#6
LETTER
J Aparicio
No abstract text is available yet for this article.
May 9, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29737461/delay-in-starting-radiotherapy-due-to-neoadjuvant-therapy-does-not-worsen-survival-in-unresected-glioblastoma-patients
#7
C Balaña, A Estival, I Teruel, M Hardy-Werbin, J Sepulveda, E Pineda, M Martinez-García, O Gallego, R Luque, M Gil-Gil, C Mesia, S Del Barco, A Herrero, A Berrocal, P Perez-Segura, R De Las Penas, J Marruecos, R Fuentes, G Reynes, J M Velarde, A Cardona, E Verger, C Panciroli, S Villà
PURPOSE: We retrospectively examined the potential effect on overall survival (OS) of delaying radiotherapy to administer neoadjuvant therapy in unresected glioblastoma patients. PATIENTS AND METHODS: We compared OS in 119 patients receiving neoadjuvant therapy followed by standard treatment (NA group) and 96 patients receiving standard treatment without neoadjuvant therapy (NoNA group). The MaxStat package of R identified the optimal cut-off point for waiting time to radiotherapy...
May 8, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29736694/pre-surgical-trial-of-the-akt-inhibitor-mk-2206-in-patients-with-operable-invasive-breast-cancer-a-new-york-cancer-consortium-trial
#8
K Kalinsky, J A Sparano, X Zhong, E Andreopoulou, B Taback, L Wiechmann, S M Feldman, P Ananthakrishnan, A Ahmad, S Cremers, A N Sireci, J R Cross, D K Marks, P Mundi, E Connolly, K D Crew, M A Maurer, H Hibshoosh, S Lee, D L Hershman
INTRODUCTION: The PI3K/AKT/mTOR pathway is an oncogenic driver in breast cancer (BC). In this multi-center, pre-surgical study, we evaluated the tissue effects of the AKT inhibitor MK-2206 in women with stage I-III BC. MATERIALS AND METHODS: Two doses of weekly oral MK2206 were administered at days - 9 and - 2 before surgery. The primary endpoint was reduction of pAktSer473 in breast tumor tissue from diagnostic biopsy to surgery. Secondary endpoints included changes in PI3K/AKT pathway tumor markers, tumor proliferation (ki-67), insulin growth factor pathway blood markers, pharmacokinetics (PK), genomics, and MK-2206 tolerability...
May 7, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29721766/radiotherapy-volume-delineation-using-18f-fdg-pet-ct-modifies-gross-node-volume-in-patients-with-oesophageal-cancer
#9
E Jimenez-Jimenez, P Mateos, N Aymar, R Roncero, I Ortiz, M Gimenez, J Pardo, J Salinas, S Sabater
PURPOSE: Evidence supporting the use of 18F-FDG-PET/CT in the segmentation process of oesophageal cancer for radiotherapy planning is limited. Our aim was to compare the volumes and tumour lengths defined by fused PET/CT vs. CT simulation. MATERIALS AND METHODS: Twenty-nine patients were analyzed. All patients underwent a single PET/CT simulation scan. Two separate GTVs were defined: one based on CT data alone and another based on fused PET/CT data. Volume sizes for both data sets were compared and the spatial overlap was assessed by the Dice similarity coefficient (DSC)...
May 2, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29721765/a-survey-of-perceptions-attitudes-knowledge-and-practices-of-medical-oncologists-about-cancer-pain-management-in-spain
#10
Jesús García-Mata, Cecilio Álamo, Javier de Castro, Jorge Contreras, Rafael Gálvez, Carlos Jara, Antonio Llombart, Concepción Pérez, Pedro Sánchez, Susana Traseira, Juan-Jesús Cruz
PURPOSE: To monitor oncologists' perspective on cancer pain management. METHODS: An anonymized survey was conducted in two waves. First, over a convenience sample of oncologists known to be particularly concerned with the management of pain. Second, using a random sample of oncologists. RESULTS: In total, 73 and 82 oncologists participated in the first and second wave, respectively. Many oncologists reported to have good knowledge of analgesic drugs (95...
May 2, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29704232/prognostic-and-microrna-profile-analysis-for-cd44-positive-expression-pediatric-posterior-fossa-ependymoma
#11
C Shu, Q Wang, X Yan, J Wang
BACKGROUND: Ependymoma is the third most common pediatric brain tumor and occurs most frequently in the posterior fossa. However, the lack of immortalized cell lines, xenografts, or animal models has significantly hindered the study of pediatric posterior fossa ependymoma (P-PF-EPN) pathogenesis. This prompted us to use clinical big data to study this rare disease. METHODS: Application of the robust rank aggregation method revealed CD44 as a reliable biomarker in P-PF-EPN...
April 27, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29704231/management-of-extravasation-of-oxaliplatin-by-mimicking-its-biotransformation
#12
F Bahadori, M Demiray
Although oxaliplatin (Oxali) plays a key role in the treatment of many types of cancer and has been reported to be an irritant, there is no specific and effective method for its extravasation and failure in Oxali extravasation management results in the need for plastic surgery. In the body, Oxali bio-transforms upon dilution in chloride-containing buffer salts to its di-chloro derivative and loses an oxalate molecule. Consequently, the chloride ions exchange with water molecules in the intracellular environment to produce the di-aqua derivative, which is the most active biotransformation product of Oxali in terms of forming the DNA adducts...
April 27, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29696478/concurrent-chemoradiation-for-locally-advanced-stage-iii-non-small-cell-lung-cancer-with-cisplatin-vinorelbine-and-thoracic-radiotherapy-a-phase-ii-study-from-the-galician-lung-cancer-group
#13
M Costa Rivas, G Huidobro Vence, J L Fírvida Pérez, B Campos Balea, J García Gonzalez, M Lázaro Quintela, M Caeiro Muñoz, B Taboada Valladares, J E Castro Gómez, S Vázquez Estevez, F J Afonso Afonso, C Azpitarte Raposeiras, M Amenedo Gancedo, J Casal Rubio
PURPOSE: The aim of this phase II study was to evaluate the activity and safety of the combination of cisplatin and vinorelbine with thoracic radiotherapy in unresectable locally advanced stage III non-small cell lung cancer (NSCLC). The primary endpoint was the objective response rate (ORR). Secondary objectives included toxicity profile, progression-free survival (PFS), and overall survival (OS). MATERIALS AND METHODS: A total of 48 NSCLC patients were enrolled (median age 60 years, 52% stage IIIA and 48% stage IIIB, 52% adenocarcinoma)...
April 25, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29675778/systematic-review-of-the-mesopancreas-concept-and-clinical-implications
#14
REVIEW
J M Ramia, R De-la-Plaza, A Manuel-Vazquez, A Lopez-Marcano, R Morales
BACKGROUND: In 2007, Gockel et al. coined the term mesopancreas (MP). In the next 10 years, a limited number of publications about MP have been published, but little is known about the oncological benefit of MP resection. We performed a systematic review of the literature on MP. METHODS: An electronic search was performed in PubMed, EMBASE, Cochrane, Latindex, Scielo, and Koreamed databases until 15 June 2017 to identify all published articles dealing with the subject of MP...
April 19, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29671223/laparoscopic-paraaortic-surgical-staging-in-locally-advanced-cervical-cancer-a-single-center-experience
#15
D Vázquez-Vicente, B Fernández Del Bas, J García Villayzán, H A Di Fiore, J Luna Tirado, V Casado Echarren, J García-Foncillas, J Plaza Arranz, L Chiva
BACKGROUND: One aim of this study was to assess the efficacy and safety of laparoscopic paraaortic lymphadenectomy for paraaortic lymph node staging in locally advanced cervical carcinoma. The second aim was to identify prognostic factors in the evolution of this disease and to evaluate how the results of the surgery modify the oncological treatment of patients. MATERIALS AND METHODS: We analyzed 59 patients diagnosed with locally advanced cervical cancer International Federation of Gynecology and Obstetrics stage IB2-IVA who underwent laparoscopic paraaortic lymphadenectomy at our hospital between 2009 and 2015...
April 18, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29671222/prognostic-value-of-ki-67-according-to-age-in-patients-with-triple-negative-breast-cancer
#16
V Zenzola, M A Cabezas-Quintario, M Arguelles, E Pérez-Fernández, Y Izarzugaza, A Correa, J García-Foncillas
PURPOSE: The prognostic value of Ki-67 in triple-negative breast cancer (TNBC) is yet unclear because the cut-off points employed differ widely and its predictive effect may vary according to age. The purpose of this study was to analyze the role of Ki-67 among patients with TNBC, and determine the optimal Ki-67 cut-off point to demonstrate its prognostic relevance associated with patient age and treatment strategy. METHODS/PATIENTS: 201 consecutive patients treated for primary TNBC from 1999 to 2014 were analyzed...
April 18, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29667123/peritoneal-carcinomatosis-arising-from-rectal-or-colonic-adenocarcinoma-treated-with-cytoreductive-surgery-crs-hyperthermic-intraperitoneal-chemotherapy-hipec-two-different-diseases
#17
M Tonello, G Ortega-Perez, O Alonso-Casado, P Torres-Mesa, G Guiñez, S Gonzalez-Moreno
PURPOSE: Peritoneal carcinomatosis (PC) from colorectal cancer (CRC) has poor survival. Multi-modal treatment including systemic chemotherapy, cytoreductive surgery (CRS), and hyperthermic intraperitoneal chemotherapy (HIPEC) can be used in selected patients with curative intent. The majority published works consider PC of CRC origin as a homogenous disease. Aim of this study is to stress the different biological behaviors and survival of PC according to colonic or rectal origin. METHODS: Data of CRS and HIPEC procedures for PC of CRC origin performed at MD Anderson Cancer Center-Madrid (Spain) have been collected, dividing patients into two groups according to colonic or rectal PC...
April 17, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29651672/factors-associated-with-anxiety-and-depression-in-cancer-patients-prior-to-initiating-adjuvant-therapy
#18
P Jimenez-Fonseca, C Calderón, R Hernández, T Ramón Y Cajal, M Mut, A Ramchandani, O Donnay, A Carmona-Bayonas
OBJECTIVE: Anxiety and depression affect cancer patients' quality of life. Our objectives were to determine the prevalence of anxiety and depression and analyze the association between positive psychological factors, sociodemographic factors, and clinical factors in oncological patients initiating adjuvant treatment. METHODS: A prospective, multicenter cohort of 600 consecutive patients completed the Brief Symptom Inventory, Mini-Mental Adjustment to Cancer, Life Orientation Scale-Revised, and Multidimensional Scale of Perceived Social Support questionnaires...
April 12, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29651671/are-endometrial-cancer-radiotherapy-results-age-related
#19
Á Rovirosa, K S Cortés, C Ascaso, A Glickman, S Valdés, A Herreros, C Camacho, J Sánchez, Y Zhang, Y Li, S Sabater, M Arenas, A Torne
OBJECTIVE: To analyze the impact of age on radiotherapy results based on cancer-specific survival (CSS), vaginal-cuff relapses (VCR) and complications analysis in 438 patients with endometrial carcinoma (EC) receiving postoperative radiotherapy (PRT) divided into three age groups for analysis. MATERIALS AND METHODS: From 2003 to 2015, 438 patients with EC were treated with PRT and divided into three age groups: Group-1: 202 patients < 65 years; Group-2: 210 patients ≥ 65 and < 80 years; Group-3: 26 patients ≥ 80 years...
April 12, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29633185/re-expression-of-microrna-4319-inhibits-growth-of-prostate-cancer-via-her-2-suppression
#20
X Lin, Y Wang
PURPOSE: Her-2 is an epidermal growth factor receptor expressed in some prostate cancers (PC) associated with outgrowth of the tumor. Dysregulation of some microRNAs is involved in the regulation of PC pathogenesis, whereas the role of miR-4319 in PC is unknown and addressed in the current study. METHODS: The levels of miR-4319 in PC tissues were determined by RT-qPCR and their association with patient survival was studied by Kaplan-Meier analysis. Targeted genes for miR-4319 were predicted by a bioinformatics algorithm and confirmed by a dual-luciferase reporter assay...
April 9, 2018: Clinical & Translational Oncology
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