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Cough

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https://www.readbyqxmd.com/read/24649919/a-real-life-observational-pilot-study-to-evaluate-the-effects-of-two-week-treatment-with-montelukast-in-patients-with-chronic-cough
#1
Roxana K Mincheva, Tanya Z Kralimarkova, Miroslava Rasheva, Zlatko Dimitrov, Denislava Nedeva, Maria Staevska, Vera Papochieva, Penka Perenovska, Karina Bacheva, Vasil D Dimitrov, Todor A Popov
BACKGROUND: Different conditions make the proximal airways susceptible to tussigenic stimuli in the chronic cough (CC) syndrome. Leukotrienes can be implicated in the inflammatory mechanism at play in it. Montelukast is a selective cysteinyl-leukotriene receptor antagonist with proven effectiveness in patients with asthma. The aim of our real-life pilot study was to use montelukast to relieve cough symptoms in patients with CC allegedly due to the two frequent causes other than asthma - upper airway cough syndrome and gastroesophageal reflux (GER)...
March 20, 2014: Cough
https://www.readbyqxmd.com/read/25632296/a-crossover-randomized-comparative-study-of-zofenopril-and-ramipril-on-cough-reflex-and-airway-inflammation-in-healthy-volunteers
#2
Federico Lavorini, Elisa Chellini, Margherita Innocenti, Giacomo Campi, Colin Gerard Egan, Selene Mogavero, Giovanni A Fontana
BACKGROUND: Persistent dry cough is a well known unwanted effect of Angiotensin-Converting Enzyme inhibitors (ACE-i). Animal studies have shown that the ACE-i zofenopril has a less tussigenic effect compared to the widely used ACE-i ramipril. The aim of this study was to compare cough sensitivity to inhaled tussigens, as well as spontaneous cough in response to the administration of zofenopril and ramipril in healthy volunteers; pharmacokinetic (PK) data of both zofenopril and ramipril, as well as their respective active forms, zofenoprilat and ramiprilat, was also collected...
2014: Cough
https://www.readbyqxmd.com/read/25342957/standardized-method-for-solubility-and-storage-of-capsaicin-based-solutions-for-cough-induction
#3
Michael T Costanzo, Richard A Yost, Paul W Davenport
BACKGROUND: Preparation of inhaled capsaicin solutions for cough induction varies greatly from one lab to another, which creates inconsistencies between tussigenic challenge results. The addition of Tween to these capsaicin solutions provides increased solubility and stability; however, the foul taste of Tween makes inhaling the solution for any prolonged period of time unpleasant. We sought to create a standard method for preparing soluble and stable capsaicin-based solutions (in 10% ethanol/water), without the addition of Tween...
2014: Cough
https://www.readbyqxmd.com/read/25009577/on-the-definition-of-chronic-cough-and-current-treatment-pathways-an-international-qualitative-study
#4
Shoaib Faruqi, Robert D Murdoch, Fabrice Allum, Alyn H Morice
BACKGROUND: The pathogenesis of chronic cough is not well understood and treatment options are limited. In this study we sought to explore the current understanding and management of chronic cough across an international group of specialists. METHODS: This was an international study of cross sectional qualitative design. In depth interviews were carried out with "Respiratory Specialists" experienced in treating treating Chronic Obstructive Pulmonary Disease (COPD), idiopathic pulmonary fibrosis (IPF), idiopathic chronic cough (ICC) and/or lung cancer patients and with "Disease Experts" in the field of Chronic Cough...
2014: Cough
https://www.readbyqxmd.com/read/24876887/effect-of-acid-suppression-therapy-on-gastroesophageal-reflux-and-cough-in-idiopathic-pulmonary-fibrosis-an-intervention-study
#5
Claire E Kilduff, Melanie J Counter, Gareth A Thomas, Nicholas K Harrison, Benjamin D Hope-Gill
BACKGROUND: Chronic cough affects more than 70 percent of patients with Idiopathic Pulmonary Fibrosis and causes significant morbidity. Gastroesophageal reflux is the cause of some cases of chronic cough; and also has a postulated role in the aetiology of Idiopathic Pulmonary Fibrosis. A high prevalence of acid; and more recently non-acid, reflux has been observed in Idiopathic Pulmonary Fibrosis cohorts. Therefore, gastroesophageal reflux may be implicated in the pathogenesis of cough in Idiopathic Pulmonary Fibrosis...
2014: Cough
https://www.readbyqxmd.com/read/24667072/severity-of-cough-in-idiopathic-pulmonary-fibrosis-is-associated-with-muc5-b-genotype
#6
Mary Beth Scholand, Roger Wolff, Peter Fredrick Crossno, Krishna Sundar, Molly Winegar, Spencer Whipple, Patrick Carey, Nicholas Sunchild, Hilary Coon
BACKGROUND: A polymorphism (rs35705950) in the promoter region of the mucin MUC5B is associated with both familial and sporadic forms of idiopathic pulmonary fibrosis. (IPF) We hypothesize that this common MUC5B variant will impact the expression of cough, a frequent disabling symptom seen in subjects with IPF. METHODS: We genotyped 136 subjects with IPF. All living subjects were provided with a Leicester Cough Questionnaire (LCQ) to measure cough severity. We assessed allele effects of the MUC5B polymorphism on the LCQ scores using SAS General Linear Models (GLM) in the patients with IPF...
2014: Cough
https://www.readbyqxmd.com/read/24552215/development-and-validation-of-the-newcastle-laryngeal-hypersensitivity-questionnaire
#7
Anne E Vertigan, Sarah L Bone, Peter G Gibson
BACKGROUND: Laryngeal hypersensitivity may be an important component of the common disorders of laryngeal motor dysfunction including chronic refractory cough, pdoxical vocal fold movement (vocal cord dysfunction), muscle tension dysphonia, and globus pharyngeus. Patients with these conditions frequently report sensory disturbances, and an emerging concept of the 'irritable larynx' suggests common features of a sensory neuropathic dysfunction as a part of these disorders. The aim of this study was to develop a Laryngeal Hypersensitivity Questionnaire for patients with laryngeal dysfunction syndromes in order to measure the laryngeal sensory disturbance occurring in these conditions...
2014: Cough
https://www.readbyqxmd.com/read/24380385/dietary-intervention-in-the-treatment-of-patients-with-cough-and-symptoms-suggestive-of-airways-reflux-as-determined-by-hull-airways-reflux-questionnaire
#8
Joanna Elizabeth Smith, Jaymin Bhagwanji Morjaria, Alyn Hugh Morice
BACKGROUND: Chronic cough is a common and distressing symptom. Gastro-oesophageal reflux is a common cause of chronic cough however the symptom complex in cough is not confined to classic peptic symptoms. Dyspeptic symptoms have previously been shown to respond to dietary modifications and weight loss. We hypothesised that weight reduction maybe a useful non-pharmacological strategy in reducing reflux cough in the obese. METHODS: Subjects with cough were recruited from Hull Cough Clinic...
December 31, 2013: Cough
https://www.readbyqxmd.com/read/24294924/airway-oxidative-stress-in-chronic-cough
#9
Heikki O Koskela, Minna K Purokivi
BACKGROUND: The mechanisms of chronic cough are unclear. Many reactive oxygen species affect airway sensory C-fibres which are capable to induce cough. Several chronic lung diseases are characterised by cough and oxidative stress. In asthma, an association between the cough severity and airway oxidative stress has been demonstrated. The present study was conducted to investigate whether airway oxidative stress is associated with chronic cough in subjects without chronic lung diseases...
December 2, 2013: Cough
https://www.readbyqxmd.com/read/24188336/chronic-cough-and-obstructive-sleep-apnoea-in-a-sleep-laboratory-based-pulmonary-practice
#10
Tsai-Yu Wang, Yu-Lun Lo, Wen-Te Liu, Shu-Min Lin, Ting-Yu Lin, Chih-Hsi Kuo, Fu-Tsai Chung, Pai-Chien Chou, Po-Jui Chang, Yung-Lun Ni, Shu-Chuan Ho, Horng-Chyuan Lin, Chun-Hua Wang, Chih-Teng Yu, Han-Pin Kuo
BACKGROUND: Obstructive sleep apnoea (OSA) has recently been identified as a possible aetiology for chronic cough. The aim of this study was to compare the incidence of chronic cough between patients with and without OSA and the impact of continuous positive airway pressure (CPAP) treatment in resolving chronic cough. METHODS: Patients referred to the sleep laboratory from January 2012 to June 2012 were retrospectively enrolled. Clinical data, treatment course and resolution of chronic cough were analysed...
November 5, 2013: Cough
https://www.readbyqxmd.com/read/23835047/epidemiology-of-cough-in-relation-to-china
#11
Kefang Lai, Jiayu Pan, Ruchong Chen, Baojuan Liu, Wei Luo, Nanshan Zhong
Cough is one of the most common complaints for which patients seek medical attention. Misdiagnosis and mistreatment of cough exist commonly in China. The prevalence of acute cough caused by upper airway infection fluctuates between 9% and 64% in the community, for chronic cough, the prevalence >10% in most surveys, ranging from 7.2%-33%. The common causes of chronic cough are upper airway cough syndrome (previously called as post nasal drip syndrome [PNDS]), cough variant asthma (CVA), gastroesophageal reflux related cough (GERD) and eosinophilic bronchitis (EB)...
July 8, 2013: Cough
https://www.readbyqxmd.com/read/23732122/the-larynx-in-cough
#12
Guri S Sandhu, Romana Kuchai
About 40% of the population will experience chronic cough at some point during their lives and it tends to be more common in women (Thorax 58:901-7, 2003). Post-nasal drip (or upper airway cough syndrome), gastro-esophageal reflux disease and asthma are considered the most common causes. Yet only a small percentage of patients with these common conditions experience chronic cough. Also there is no agreed measure of post-nasal drip and controversy exists about the diagnosis of reflux above the upper esophageal sphincter (laryngopharyngeal reflux) based on observable changes to the larynx...
June 3, 2013: Cough
https://www.readbyqxmd.com/read/23668427/chronic-cough-hypersensitivity-syndrome
#13
Alyn H Morice
Chronic cough has been suggested to be due to three conditions, asthma, post nasal drip, and reflux disease. A different paradigm has evolved in which cough is viewed as the primary condition characterised by afferent neuronal hypersensitivity and different aspects of this syndrome are manifest in the different phenotypes of cough. There are several advantages to viewing cough hypersensitivity as the unifying diagnosis; Communication with patients is aided, aetiology is not restricted and therapeutic avenues opened...
May 13, 2013: Cough
https://www.readbyqxmd.com/read/23639195/summary-of-papers-presented-at-the-2012-seventh-international-cough-symposium
#14
Peter V Dicpinigaitis, Giovanni A Fontana, Lu-Yuan Lee, Milos Tatar
Twenty six papers were presented as posters in the Seventh International Symposium on Cough; 12 papers were presented in the Basic Science of Cough session, and 14 papers presented in the Clinical Science of Cough session. These papers explored a wide spectrum of cough-related areas including pathophysiological mechanisms, treatment and detection of cough, and symptom assessment and perception, and were grouped into several general themes for facilitate the discussion. Studies presented in these posters have provided new information that should improve our knowledge on the basic physiology and pharmacology of cough, and the peripheral and central neural mechanisms involved in the generation of the cough motor pattern...
May 2, 2013: Cough
https://www.readbyqxmd.com/read/23590893/the-oesophagus-and-cough-laryngo-pharyngeal-reflux-microaspiration-and-vagal-reflexes
#15
Jaclyn A Smith, Lesley A Houghton
Gastro-oesophageal reflux disease is generally considered to be one of the commonest causes of chronic cough, however randomised controlled trials of proton pump inhibitors have often failed to support this notion. This article reviews the most recent studies investigating the mechanisms thought to link reflux and cough, namely laryngo-pharyngeal reflux, micro-aspiration and neuronal cross-organ sensitisation. How recent evidence might shed light on the failure of acid suppressing therapies and suggest new approaches to treating reflux related cough are also discussed...
April 16, 2013: Cough
https://www.readbyqxmd.com/read/23574624/the-difficult-coughing-child-prolonged-acute-cough-in-children
#16
Michael D Shields, Surendran Thavagnanam
Cough is one of the most common symptoms that patients bring to the attention of primary care clinicians. Cough can be designated as acute (<3 weeks in duration), prolonged acute cough (3 to 8 weeks in duration) or chronic (> 8 weeks in duration). The use of the term 'prolonged acute cough' in a cough guideline allows a period of natural resolution to occur before further investigations are warranted. The common causes are in children with post viral or pertussis like illnesses causing the cough. Persistent bacterial bronchitis typically occurs when an initial dry acute cough due to a viral infection becomes a prolonged wet cough remaining long after the febrile illness has resolved...
April 10, 2013: Cough
https://www.readbyqxmd.com/read/23552099/refractory-chronic-cough-or-the-need-to-focus-on-the-relationship-between-the-larynx-and-the-esophagus
#17
Adalberto Pacheco, Ignacio Cobeta
In this review we question the current way of handling tackle a problem of chronic cough, especially by the excessive number of patients who can not find complete relief from your cough by anatomical diagnosis of universal use. From the field of Otolaryngology new perspectives arise now considering the larynx as a preferential afferent stimuli cough reflex arc. Also the constitution laryngopharyngeal reflux gas and new approaches to non-acid reflux and the local action of pepsin in laryngeal deserving of a joint review, which can illuminate new ways to handle the problem of chronic refractory cough...
April 3, 2013: Cough
https://www.readbyqxmd.com/read/23497684/molecular-signaling-and-targets-from-itch-lessons-for-cough
#18
Pamela Colleen Lavinka, Xingzhong Dong
Itch is described as an unpleasant sensation that elicits the desire to scratch, which results in the removal of the irritant from the skin. The cough reflex also results from irritation, with the purpose of removing said irritant from the airway. Could cough then be similar to itch? Anatomically, both pathways are mediated by small-diameter sensory fibers. These cough and itch sensory fibers release neuropeptides upon activation, which leads to inflammation of the nerves. Both cough and itch also involve mast cells and their mediators, which are released upon degranulation...
March 6, 2013: Cough
https://www.readbyqxmd.com/read/23497672/sensorimotor-circuitry-involved-in-the-higher-brain-control-of-coughing
#19
Stuart B Mazzone, Alice E McGovern, Seung-Kwon Yang, Ariel Woo, Simon Phipps, Ayaka Ando, Jennifer Leech, Michael J Farrell
There is an overwhelming body of evidence to support the existence of higher brain circuitries involved in the sensory detection of airways irritation and the motor control of coughing. The concept that cough is purely a reflex response to airways irritation is now superseded by the recognition that perception of an urge-to-cough and altered behavioral modification of coughing are key elements of cough disorders associated with airways disease. Understanding the pathways by which airway sensory nerves ascend into the brain and the patterns of neural activation associated with airways irritation will undoubtedly provide new insights into disordered coughing...
March 6, 2013: Cough
https://www.readbyqxmd.com/read/23448366/capsaicin-sensitivity-in-patients-with-chronic-cough-results-from-a-cross-sectional-study
#20
Ewa Ternesten-Hasséus, Christel Larsson, Sven Larsson, Eva Millqvist
BACKGROUND: A subgroup of patients with chronic cough is recognised as having airway symptoms resulting exposure to chemicals and scents related to enhanced cough sensitivity to inhaled capsaicin. Sensory hyperreactivity, which has an estimated prevalence of more than 6%, is one possible explanation for the symptoms experienced by these patients. We hypothesized that a number of patients diagnosed with chronic unexplained cough also have coughing provoked by chemical irritants associated with augmented capsaicin cough reaction, but the extent of such a relation is not known...
February 28, 2013: Cough
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