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Journal of Occupational Medicine and Toxicology

Christoph Gyo, Michael Boll, Dörthe Brüggmann, Doris Klingelhöfer, David Quarcoo, David A Groneberg
BACKGROUND: State-certified occupational physicians who work as civil servants in the Federal Republic of Germany are key players in the German Public Health system. They control i.e. the legal compliance in occupational health and participate in the occupational disease procedures. Despite the role model function of the German Public health system for many developing countries, this area of Public health is debated to have been hampered in the past years by a disregard concerning structural developments...
2016: Journal of Occupational Medicine and Toxicology
Sanja Stopinšek, Alojz Ihan, Barbara Salobir, Marjeta Terčelj, Saša Simčič
BACKGROUND: Composition of organic dust is very complex, involving particles of microbial, animal and plant origin. Several environmental exposure studies associate microbial cell wall agents in organic dust with various respiratory symptoms and diseases. The aim of the present study was to investigate the in vitro effects of the co-exposure of fungal cell wall agents (FCWAs) and bacterial lipopolysaccharide (LPS) on inflammatory immune responses of peripheral blood mononuclear cells (PBMCs) from patients with pulmonary sarcoidosis...
2016: Journal of Occupational Medicine and Toxicology
Lilli Kirkeskov, Dorte Jessing Agerby Hanskov, Charlotte Brauer
BACKGROUND: Within the construction industry the risk of lung disorders depends on the specific professions probably due to variations in the levels of dust exposure, and with dust levels depending on the work task and job function. We do not know the extent of exposure in the different professions or the variation between the different work tasks. The purpose of this study was therefore to assess if there were differences in dust exposure between carpenters and demolition workers who were expected to have low and high dust exposure, respectively...
2016: Journal of Occupational Medicine and Toxicology
Makoto Ohnishi, Masaaki Suzuki, Masahiro Yamamoto, Tatsuya Kasai, Hirokazu Kano, Hideki Senoh, Ichiro Higashikubo, Akihiro Araki, Shoji Fukushima
BACKGROUND: Previously, we have developed and reported the method of measuring multi-walled carbon nanotube (MWCNT) in the lung from rats exposed to MWCNT intratracheally. The present research was performed to improve the analytical method of MWCNT to measure multiple samples in a short period of time. For the xanalysis of MWCNTs from tissues, the existence of carbon black may interfere. Therefore, it was examined whether or not carbon black interfere the determination of MWCNT in the standard solutions...
2016: Journal of Occupational Medicine and Toxicology
Michael H K Bendels, Dörthe Brüggmann, Norman Schöffel, David A Groneberg
BACKGROUND: Imbalances in female career promotion are believed to be strong in the field of academic science. A primary parameter to analyze gender inequalities is the gender authoring in scientific publications. Since the presently available data on gender distribution is largely limited to underpowered studies, we here develop a new approach to analyze authors' genders in large bibliometric databases. RESULTS: A SQL-Server based multiuser software suite was developed that serves as an integrative tool for analyzing bibliometric data with a special emphasis on gender and topographical analysis...
2016: Journal of Occupational Medicine and Toxicology
Katrin Bossmann, Sabine Bach, Conny Höflich, Kerttu Valtanen, Rita Heinze, Anett Neumann, Wolfgang Straff, Katrin Süring
BACKGROUND: At Holi festivals, originally celebrated in India but more recently all over the world, people throw coloured powder (Holi powder, Holi colour, Gulal powder) at each other. Adverse health effects, i.e. skin and ocular irritations as well as respiratory problems may be the consequences. The aim of this study was to uncover some of the underlying mechanisms. METHODS: We analysed four different Holi colours regarding particle size using an Electric field cell counting system...
2016: Journal of Occupational Medicine and Toxicology
Birte Pantenburg, Katharina Kitze, Melanie Luppa, Hans-Helmut König, Steffi G Riedel-Heller
BACKGROUND: Physician migration is gaining attention worldwide. Despite increasing numbers of foreign physicians in Germany, their perceptions on working in Germany remain unexplored. Within a large survey on Saxon physicians, the aim of this study was to elucidate whether foreign-national physicians' job satisfaction differed from German physicians' job satisfaction. METHODS: The study was designed as a comprehensive cross-sectional survey. All physicians ≤40 years and registered with the State Chamber of Physicians of Saxony (n = 5956) were mailed a paper-pencil questionnaire, of which 2357 were returned (response rate = 40 %)...
2016: Journal of Occupational Medicine and Toxicology
Ove Björ, Håkan Jonsson, Lena Damber, Lage Burström, Tohr Nilsson
BACKGROUND: A cohort study that examined iron ore mining found negative associations between cumulative working time employed underground and several outcomes, including mortality of cerebrovascular diseases. In this cohort study, and using the same group of miners, we examined whether work in an outdoor environment could explain elevated cerebrovascular disease rates. METHODS: This study was based on a Swedish iron ore mining cohort consisting of 13,000 workers...
2016: Journal of Occupational Medicine and Toxicology
Zorawar Singh, Pooja Chadha
BACKGROUND AND SUMMARY: Thousands of workers are engaged in textile industry worldwide. Textile industry involves the use of different kinds of dyes which are known to possess carcinogenic properties. Solvents used in these industries are also associated with different health related hazards including cancer. In previous studies on textile and iron industries, the authors have reported genotoxicity among them and observed occurrence of cancer deaths among textile industry workers. Thus, an attempt has been made to compile the studies on the prevalence of different types of cancers among textile industry workers...
2016: Journal of Occupational Medicine and Toxicology
Kristinn Tomasson, Gunnar Gudmundsson, Haraldur Briem, Vilhjalmur Rafnsson
BACKGROUND: Malignant mesothelioma caused by asbestos exposure has a long latency period. A ban on asbestos use may not be apparent in decreased incidence in the population until after several decades. The aim was to evaluate changes in the incidence of malignant mesothelioma, and the possible impact of the asbestos ban implemented in Iceland in 1983. METHODS: This is a population study on aggregate level; the source of data was the Icelandic Cancer Registry, the National Cause-of-Death Registry, and the National Register...
2016: Journal of Occupational Medicine and Toxicology
Peter Grešner, Radosław Świercz, Magdalena Beata Król, Ewa Twardowska, Jolanta Gromadzińska, Wojciech Wąsowicz
BACKGROUND: In this study we tested whether the seasonal variations in levels of selected biomarkers of oxidative stress in female nail technicians occupationally exposed to low levels of volatile organic compounds (VOCs) differ significantly from those observed among healthy unexposed controls. Airborne levels of selected VOCs in nail salons were also analyzed and tested for associations with seasonal variations of the levels of biomarkers among nail technicians. METHODS: The study enrolled 145 female nail technicians and 145 healthy unexposed female controls...
2016: Journal of Occupational Medicine and Toxicology
Enzo Emanuelli, Enrico Alexandre, Diego Cazzador, Vera Comiati, Tiziana Volo, Alessia Zanon, Maria Luisa Scapellato, Mariella Carrieri, Alessandro Martini, Giuseppe Mastrangelo
BACKGROUND AND AIMS: Sinonasal cancers (SNCs) are rare neoplasms, accounting for about 3 % of head and neck cancers, with squamous cell carcinoma (SCC) and adenocarcinoma (ADC) as the most common subtypes. ADCs present strong associations with occupational wood dust exposure. Preventive measures have progressively reduced wood dust concentrations in workplaces but no study has evaluated the effectiveness of such interventions. Few studies indicate associations between ADC and exposure to solvents, which is common in the shoe industry, but this hypothesis still needs confirmation...
2016: Journal of Occupational Medicine and Toxicology
Daniela Ohlendorf, Christoph Mickel, Natalie Filmann, Eileen M Wanke, David A Groneberg
BACKGROUND: Decisions on orthopedic interventions on upper body posture and its control have usually resulted from comparisons with the healthy state. Therefore, practitioners as well as scientists in human movement science or orthopedics need access to such kind of data which are patient-centered and well measured. Until now, these data have been missing concerning upper body posture as well as postural control and their control. That is why the aim of the current project is to measure these data with healthy participants across the lifespan...
2016: Journal of Occupational Medicine and Toxicology
Mónica Villalba-Campos, Sandra Rocío Ramírez-Clavijo, Magda Carolina Sánchez-Corredor, Milena Rondón-Lagos, Milcíades Ibáñez-Pinilla, Ruth Marien Palma, Marcela Eugenia Varona-Uribe, Lilian Chuaire-Noack
BACKGROUND: For several years, cell-free DNA has been emerging as an important biomarker for non-invasive diagnostic in a wide range of clinical conditions and diseases. The limited information available on the genotoxic effects associated with occupational exposure to car paints, as well as the fact that up-to-date there are not reports about cell-free DNA measurements for assessing this condition, led us to evaluate the DNA damage caused by the occupational exposure to organic solvents contained in car paints, through the quantification of the cell-free DNA and the comet assay, in a sample of 33 individuals taken from 10 automobile paint shops located in Bogota DC, Colombia...
2016: Journal of Occupational Medicine and Toxicology
Menen E Mund, Christoph Gyo, Dörthe Brüggmann, David Quarcoo, David A Groneberg
Acetylsalicylic acid is a frequently used medication worldwide. It is not used in pediatrics due its association with Reye syndrome. However, in case of pediatric intoxication, children are more fragile to salicylate poisoning because of their reduced ability of buffer the acid stress. Intoxication leads to a decoupling of oxidative phosphorylation and subsequently to a loss in mitochondrial function. Symptoms of poisoning are diverse; eventually they can lead to the death of the patient. Governmental websites of various EU countries were searched for legal information on acetylsalicylic acid availability in pharmacies and non-pharmacy stores...
2016: Journal of Occupational Medicine and Toxicology
David Schneberger, Gurpreet Aulakh, Shankaramurthy Channabasappa, Baljit Singh
BACKGROUND: Exposure to animal barn air is an occupational hazard that causes lung dysfunction in barn workers. Respiratory symptoms experienced by workers are typically associated with endotoxin and TLR4 signalling, but within these environments gram negative bacteria constitute only a portion of the total microbial population. In contrast, unmethylated DNA can be found in all bacteria, some viruses, and mold. We hypothesized that in such environments TLR9, which binds unmethylated DNA, contributes to the overall immune responses in the lung...
2016: Journal of Occupational Medicine and Toxicology
Steffen Roth, Anne Kristin Møller Fell
BACKGROUND: We present an unusual case of subcutaneous granulomas that also highlights the importance of assessing possible associations between exposure and symptoms early in the diagnostic approach to prevent further adverse health effects. Granulomas of the skin are seen in association with several diseases and after foreign body penetration of soft tissue, but have not been described after contact with epoxy. Epoxy resins are commonly used in paints and other protective coatings, including flooring materials...
2016: Journal of Occupational Medicine and Toxicology
Raffaela Olivieri, Sara Scarnera, Annalisa Ciabattini, Giulia De Vuono, Pietro Manzi, Gianni Pozzi, Giuseppe Battista, Donata Medaglini
BACKGROUND: Healthcare workers (HCWs) represent a tuberculosis (TB) risk group for a wide range of tasks in healthcare, even in countries with low TB incidence, like Italy. Latent Tuberculosis Infection (LTBI) screening programs are an important tool for TB prevention in these setting. METHODS: A retrospective study under a LTBI screening program among HCWs at the Siena University Hospital (Italy), was conducted between September 2011 and July 2015. Tuberculin Skin Test (TST) was used as a first level examination; all TST-positive cases were tested with QuantiFERON-TB Gold In-Tube (QFT-GIT) test, together with a group of TST-negative subjects...
2016: Journal of Occupational Medicine and Toxicology
Stéphane Du Mortier, Silas Mukangu, Charles Sagna, Laurent Nyffenegger, Sigiriya Aebischer Perone
The International Committee of the Red Cross (ICRC) works in fragile States and in armed conflict zones. Some of them are affected by the HIV pandemic. Within the framework of its social responsibility programme concerning HIV affecting its staff members, the organization has implemented an HIV workplace programme since 2004. We carried out a retrospective analysis over 10 years. Data collected were initially essentially qualitative and process-oriented, but were complemented over the years by data on annual voluntary counselling and testing (VCT) uptake and on direct annual costs covering awareness, testing and antiretroviral therapy...
2016: Journal of Occupational Medicine and Toxicology
Denis Vinnikov
BACKGROUND: Occupational studies of associations of exposures with impaired lung function in mining settings are built on exposure assessment and far less often on workplace approach, so the aim of this study was to identify vulnerable occupational groups for early lung function reduction in a cohort of healthy young miners. METHODS: Data from annual screening lung function tests in gold mining company in Kyrgyzstan were linked to occupations. We compared per cent predicted forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC between occupational groups and tested selected occupations in multivariate regression adjusted for smoking and work duration for the following outcomes: FEV1 < 80 %, FEV1/FVC < 70 % and both...
2016: Journal of Occupational Medicine and Toxicology
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