Ron Nudel, Richard Zetterberg, Nicoline Hemager, Camilla A J Christiani, Jessica Ohland, Birgitte K Burton, Aja N Greve, Katrine S Spang, Ditte Ellersgaard, Ditte L Gantriis, Jonas Bybjerg-Grauholm, Kerstin J Plessen, Jens Richardt M Jepsen, Anne A E Thorup, Thomas Werge, Ole Mors, Merete Nordentoft
Many psychiatric and neurodevelopmental disorders are known to be heritable, but studies trying to elucidate the genetic architecture of such traits often lag behind studies of somatic traits and diseases. The reasons as to why relatively few genome-wide significant associations have been reported for such traits have to do with the sample sizes needed for the detection of small effects, the difficulty in defining and characterizing the phenotypes, partially due to overlaps in affected underlying domains (which is especially true for cognitive phenotypes), and the complex genetic architectures of the phenotypes, which are not wholly captured in traditional case-control GWAS designs...
December 1, 2022: Behavioral and Brain Functions: BBF