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Clinics

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https://www.readbyqxmd.com/read/29466495/monitoring-auditory-cortical-plasticity-in-hearing-aid-users-with-long-latency-auditory-evoked-potentials-a-longitudinal-study
#1
Renata Aparecida Leite, Fernanda Cristina Leite Magliaro, Jeziela Cristina Raimundo, Ricardo Ferreira Bento, Carla Gentile Matas
OBJECTIVE: The objective of this study was to compare long-latency auditory evoked potentials before and after hearing aid fittings in children with sensorineural hearing loss compared with age-matched children with normal hearing. METHODS: Thirty-two subjects of both genders aged 7 to 12 years participated in this study and were divided into two groups as follows: 14 children with normal hearing were assigned to the control group (mean age 9 years and 8 months), and 18 children with mild to moderate symmetrical bilateral sensorineural hearing loss were assigned to the study group (mean age 9 years and 2 months)...
February 19, 2018: Clinics
https://www.readbyqxmd.com/read/29466494/granulocyte-colony-stimulating-factor-combined-with-methylprednisolone-improves-functional-outcomes-in-rats-with-experimental-acute-spinal-cord-injury
#2
William Gemio Jacobsen Teixeira, Alexandre Fogaça Cristante, Raphael Martus Marcon, Gustavo Bispo, Ricardo Ferreira, Tarcísio Eloy Pessoa de Barros-Filho
OBJECTIVES: To evaluate the effects of combined treatment with granulocyte colony-stimulating factor (G-CSF) and methylprednisolone in rats subjected to experimental spinal cord injury. METHODS: Forty Wistar rats received a moderate spinal cord injury and were divided into four groups: control (no treatment); G-CSF (G-CSF at the time of injury and daily over the next five days); methylprednisolone (methylprednisolone for 24 h); and G-CSF/Methylprednisolone (methylprednisolone for 24 h and G-CSF at the time of injury and daily over the next five days)...
February 19, 2018: Clinics
https://www.readbyqxmd.com/read/29466493/preventable-adverse-drug-events-in-critically-ill-hiv-patients-is-the-detection-of-potential-drug-drug-interactions-a-useful-tool
#3
Grazielle Viana Ramos, André Miguel Japiassú, Fernando Augusto Bozza, Lusiele Guaraldo
OBJECTIVES: The aim of this study was to develop a strategy to identify adverse drug events associated with drug-drug interactions by analyzing the prescriptions of critically ill patients. METHODS: This retrospective study included HIV/AIDS patients who were admitted to an intensive care unit between November 2006 and September 2008. Data were collected in two stages. In the first stage, three prescriptions administered throughout the entire duration of these patients' hospitalization were reviewed, with the Micromedex database used to search for potential drug-drug interactions...
February 19, 2018: Clinics
https://www.readbyqxmd.com/read/29451621/a-comparison-of-the-efficiency-of-22g-versus-25g-needles-in-eus-fna-for-solid-pancreatic-mass-assessment-a-systematic-review-and-meta-analysis
#4
Hugo Gonçalo Guedes, Diogo Turiani Hourneaux de Moura, Ralph Braga Duarte, Martin Andres Coronel Cordero, Marcos Eduardo Lera Dos Santos, Spencer Cheng, Sergio Eiji Matuguma, Dalton Marques Chaves, Wanderley Marques Bernardo, Eduardo Guimarães Hourneaux de Moura
Our aim in this study was to compare the efficiency of 25G versus 22G needles in diagnosing solid pancreatic lesions by EUS-FNA. We performed a systematic review and meta-analysis. Studies were identified in five databases using an extensive search strategy. Only randomized trials comparing 22G and 25G needles were included. The results were analyzed by fixed and random effects. A total of 504 studies were found in the search, among which 4 randomized studies were selected for inclusion in the analysis. A total of 462 patients were evaluated (233: 25G needle/229: 22G needle)...
2018: Clinics
https://www.readbyqxmd.com/read/29451620/application-of-a-pharmacokinetics-pharmacodynamics-approach-to-the-free-propofol-plasma-levels-during-coronary-artery-bypass-grafting-surgery-with-hypothermic-cardiopulmonary-bypass
#5
Carlos R Silva-Filho, Ricardo Antonio G Barbosa, Carlindo V Silva-Jr, Luiz M S Malbouisson, Maria José C Carmona, Silvia Regina C Jorge-Santos
OBJECTIVES: The objective of this study was to apply a pharmacokinetics-pharmacodynamics approach to investigate the free propofol plasma levels in patients undergoing coronary artery bypass grafting under hypothermic conditions compared with the off-pump procedure. METHODS: Nineteen patients scheduled for on-pump coronary artery bypass grafting under hypothermic conditions (n=10) or the equivalent off-pump surgery (n=9) were anesthetized with sufentanil and propofol target-controlled infusion (2 μg/mL) during surgery...
2018: Clinics
https://www.readbyqxmd.com/read/29451619/increase-of-10-in-the-rate-of-adverse-drug-reactions-for-each-drug-administered-in-hospitalized-patients
#6
Marisa Rosimeire Ribeiro, Antonio Abílio Motta, Luiz Augusto Marcondes-Fonseca, Jorge Kalil-Filho, Pedro Giavina-Bianchi
OBJECTIVE: To assess the risk factors, incidence and severity of adverse drug reactions in in-patients. METHODS: This prospective study evaluated 472 patients treated at a teaching hospital in Brazil between 2010 and 2013 by five medical specialties: Internal Medicine, General Surgery, Geriatrics, Neurology, and Clinical Immunology and Allergy. The following variables were assessed: patient age, gender, comorbidities, family history of hypersensitivity, personal and family history of atopy, number of prescribed drugs before and during hospitalization, hospital diagnoses, days of hospitalization...
2018: Clinics
https://www.readbyqxmd.com/read/29451618/the-association-of-vitamin-d-levels-and-the-frailty-phenotype-among-non-geriatric-dialysis-patients-a-cross-sectional-study
#7
Demet Tekdos Demircioglu
OBJECTIVES: The aim of this study was to investigate the frequency of frailty and the association of vitamin D levels and the frailty phenotype among non-geriatric dialysis patients. METHOD: Seventy-four stable, chronic hemodialysis patients from the hemodialysis unit of the hospital were enrolled in the study. The patients' medical histories and laboratory findings were obtained from the medical records of the dialysis unit. Serum parathyroid hormone and 25-hydroxy vitamin D levels were determined using chemiluminometric immunoassays...
2018: Clinics
https://www.readbyqxmd.com/read/29319727/risk-factors-for-the-prognosis-of-pediatric-medulloblastoma-a-retrospective-analysis-of-40-cases
#8
Jianzhong Yu, Rui Zhao, Wei Shi, Hao Li
No abstract text is available yet for this article.
December 2017: Clinics
https://www.readbyqxmd.com/read/29319726/second-hand-tobacco-smoke-adversely-affects-the-bone-of-immature-rats
#9
Rodrigo César Rosa, Sângela Cunha Pereira, Fabrizio Antônio Gomide Cardoso, Abadio Gonçalves Caetano, Hildemberg Agostinho Rocha de Santiago, José Batista Volpon
OBJECTIVES: To evaluate the influence of secondhand cigarette smoke exposure on longitudinal growth of the tibia of growing rats and some parameters of bone quality. METHODS: Forty female rats were randomly divided into four groups: control: rats were sham exposed; 30 days: rats were exposed to tobacco smoke for 30 days; 45 days: rats were exposed to tobacco smoke for 45 days; and 60 days: rats were exposed to tobacco smoke for 60 days. Blood samples were collected to evaluate the levels of cotinine and alkaline phosphatase...
December 2017: Clinics
https://www.readbyqxmd.com/read/29319725/experimental-implantation-of-an-arterial-substitute-made-of-silicone-reinforced-with-polyester-fabric-in-rabbits
#10
Laila Massad Ribas, Inez Ohashi Torres, Fernanda Appolonio, Karina Paula Domingos Rosa, Fabio Rodrigues Ferreira do Espírito-Santo, Nelson De Luccia
OBJECTIVES: The aim of this study was to analyze silicone tubes with an internal diameter of 4 mm as a possible material for vascular prostheses. METHODS: Grafts were implanted into the infrarenal aortas of 33 rabbits. Fluoroscopic examinations were performed within 150 days after surgical implantation. Sample grafts were analyzed via electron microscopy to evaluate the eventual endothelialization of the prostheses. RESULTS: The patency rates of the prostheses were 87% (±6...
December 2017: Clinics
https://www.readbyqxmd.com/read/29319724/evaluation-of-the-efficacy-and-safety-of-endovascular-management-for-transplant-renal-artery-stenosis
#11
Leonardo G M Valle, Rafael N Cavalcante, Joaquim M Motta-Leal-Filho, Breno B Affonso, Francisco L Galastri, Marisa P Doher, Nadia K Guimarães-Souza, Ana K N Cavalcanti, Rodrigo G Garcia, Álvaro Pacheco-Silva, Felipe Nasser
OBJECTIVES: To evaluate the safety and efficacy of endovascular intervention with angioplasty and stent placement in patients with transplant renal artery stenosis. METHODS: All patients diagnosed with transplant renal artery stenosis and graft dysfunction or resistant systemic hypertension who underwent endovascular treatment with stenting from February 2011 to April 2016 were included in this study. The primary endpoint was clinical success, and the secondary endpoints were technical success, complication rate and stent patency...
December 2017: Clinics
https://www.readbyqxmd.com/read/29319723/characteristics-and-outcomes-of-intensive-care-unit-survivors-experience-of-a-multidisciplinary-outpatient-clinic-in-a-teaching-hospital
#12
Péricles A D Duarte, Jaquilene Barreto Costa, Silvana Trilo Duarte, Sheila Taba, Claudia Regina Felicetti Lordani, Erica Fernanda Osaku, Claudia Rejane Lima Macedo Costa, Dalas Cristina Miglioranza, Daniela Prochnow Gund, Amaury Cesar Jorge
OBJECTIVES: To describe the experience of an outpatient clinic with the multidisciplinary evaluation of intensive care unit survivors and to analyze their social, psychological, and physical characteristics in a low-income population and a developing country. METHODS: Retrospective cohort study. Adult survivors from a general intensive care unit were evaluated three months after discharge in a post-intensive care unit outpatient multidisciplinary clinic over a period of 6 years (2008-2014) in a University Hospital in southern Brazil...
December 2017: Clinics
https://www.readbyqxmd.com/read/29319722/pain-and-quality-of-life-in-breast-cancer-patients
#13
Weruska Alcoforado Costa, Michelly Nóbrega Monteiro, Janice França Queiroz, Ana Katherine Gonçalves
OBJECTIVE: To evaluate the influence of pain on quality of life in breast cancer patients. METHODS: A cross-sectional study of 400 patients, including 118 without metastasis, 160 with loco-regional metastasis and 122 with distant metastasis. The instruments used were the European Organization for Research and Treatment for Cancer Quality of Life Questionnaire-Core 30 and the Breast Cancer-specific 23 and short McGill Pain Questionnaire. RESULTS: In total, 71...
December 2017: Clinics
https://www.readbyqxmd.com/read/29319721/microcirculation-improvement-after-short-term-infusion-of-vasopressin-in-septic-shock-is-dependent-on-noradrenaline
#14
Ana Paula Metran Nascente, Flávio Geraldo Rezende Freitas, Jan Bakker, Antônio Tonete Bafi, Renata Teixeira Ladeira, Luciano Cesar Pontes Azevedo, Alexandre Lima, Flavia Ribeiro Machado
OBJECTIVES: To assess the impact of vasopressin on the microcirculation and to develop a predictive model to estimate the probability of microcirculatory recruitment in patients with septic shock. METHODS: This prospective interventional study included patients with septic shock receiving noradrenaline for less than 48 hours. We infused vasopressin at 0.04 U/min for one hour. Hemodynamic measurements, including sidestream dark-field imaging, were obtained immediately before vasopressin infusion, 1 hour after vasopressin infusion and 1 hour after vasopressin withdrawal...
December 2017: Clinics
https://www.readbyqxmd.com/read/29319720/depression-and-adherence-to-antiretroviral-treatment-in-hiv-positive-men-in-s%C3%A3-o-paulo-the-largest-city-in-south-america-social-and-psychological-implications
#15
Ricardo Pereira de Moraes, Jorge Casseb
OBJECTIVES: The aim of the present study was to investigate the prevalence of depression and adherence to antiretroviral treatment in two groups of individuals: men who have sex with men (MSM) and men who have sex with women (MSW). METHODS: Two hundred and sixteen participants (MSM=116; MSW=100) who visited the Clinics Hospital of the School of the Medicine of the University of São Paulo completed two independent surveys (the BECK Depression Inventory and an adherence self-declared questionnaire) to evaluate their depression status and adherence to antiretroviral treatment, respectively...
December 2017: Clinics
https://www.readbyqxmd.com/read/29319719/a-new-low-cost-negative-pressure-wound-therapy-versus-a-commercially-available-therapy-device-widely-used-to-treat-complex-traumatic-injuries-a-prospective-randomized-non-inferiority-trial
#16
Fabio Kamamoto, Ana Lucia Munhoz Lima, Marcelo Rosa de Rezende, Rames Mattar-Junior, Marcos de Camargo Leonhardt, Kodi Edson Kojima, Carla Chineze Dos Santos
OBJECTIVES: Negative-pressure wound therapy has been widely adopted to reduce the complexity of treating a broad range of acute and chronic wounds. However, its cost is high. The objective of this study was to evaluate the following two different methods of negative-pressure wound therapy in terms of healing time: a low-cost method of negative-pressure wound therapy (a pressure stabilizer device connected to a hospital wall-vacuum system with a gauze-sealed dressing, USP) and the standard of care (vacuum-assisted closure, VAC)...
December 2017: Clinics
https://www.readbyqxmd.com/read/29319718/effects-of-periarticular-injection-on-analgesic-effects-and-nsaid-use-in-total-knee-arthroplasty-and-total-hip-arthroplasty
#17
Wen-Rui Ban, Ery-Ang Zhang, Lei-Feng Lv, Xiao-Qian Dang, Chen Zhang
OBJECTIVES: This study examined periarticular multimodal drug injection and the use of nonsteroidal anti-inflammatory drugs for an early analgesic effect after total knee arthroplasty and total hip arthroplasty. Patient satisfaction and benefits from the treatment were also assessed. METHODS: A total of 110 patients who were scheduled to undergo total knee arthroplasty and 86 patients who were scheduled to undergo total hip arthroplasty were divided into two groups, the study group and the control group...
December 2017: Clinics
https://www.readbyqxmd.com/read/29319717/serum-25-hydroxyvitamin-d-levels-in-patients-with-granulomatosis-with-polyangiitis-association-with-respiratory-infection
#18
Mariana O Perez, Ricardo M Oliveira, Mauricio Levy-Neto, Valeria F Caparbo, Rosa M R Pereira
OBJECTIVES: To determine the possible association of serum 25-hydroxyvitamin D (25OHD) levels with disease activity and respiratory infection in granulomatosis with polyangiitis patients during two different periods: winter/spring and summer/autumn. METHODS: Thirty-two granulomatosis with polyangiitis patients were evaluated in the winter/spring, and the same patients (except 5) were evaluated in summer/autumn (n=27). The 25OHD levels were measured by radioimmunoassay...
December 2017: Clinics
https://www.readbyqxmd.com/read/29319716/screening-protocol-for-dysphagia-in-adults-comparison-with-videofluoroscopic-findings
#19
Fernanda C Sassi, Gisele C Medeiros, Bruno Zilberstein, Shri Krishna Jayanthi, Claudia R F de Andrade
OBJECTIVES: To compare the videofluoroscopic findings of patients with suspected oropharyngeal dysphagia with the results of a clinical screening protocol. METHODS: A retrospective observational cohort study was conducted on all consecutive patients with suspected oropharyngeal dysphagia between March 2015 and February 2016 who were assigned to receive a videofluoroscopic assessment of swallowing. All patients were first submitted to videofluoroscopy and then to the clinical assessment of swallowing...
December 2017: Clinics
https://www.readbyqxmd.com/read/29236919/evidence-of-progenitor-cells-in-the-adult-human-cochlea-sphere-formation-and-identification-of-abcg2
#20
Milene Massucci-Bissoli, Karina Lezirovitz, Jeanne Oiticica, Ricardo Ferreira Bento
OBJECTIVES: The aim of this study was to search for evidence of stem or progenitor cells in the adult human cochlea by testing for sphere formation capacity and the presence of the stem cell marker ABCG2. METHODS: Cochleas removed from patients undergoing vestibular schwannoma resection (n=2) and from brain-dead organ donors (n=4) were dissociated for either flow cytometry analysis for the stem cell marker ABCG2 or a sphere formation assay that is widely used to test the sphere-forming capacity of cells from mouse inner ear tissue...
November 2017: Clinics
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