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Clinics

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https://www.readbyqxmd.com/read/28793006/osteointegration-of-porous-absorbable-bone-substitutes-a-systematic-review-of-the-literature
#1
Maria Júlia Escanhoela Paulo, Mariana Avelino Dos Santos, Bruno Cimatti, Nelson Fabrício Gava, Marcelo Riberto, Edgard Eduard Engel
Biomaterials' structural characteristics and the addition of osteoinductors influence the osteointegration capacity of bone substitutes. This study aims to identify the characteristics of porous and resorbable bone substitutes that influence new bone formation. An Internet search for studies reporting new bone formation rates in bone defects filled with porous and resorbable substitutes was performed in duplicate using the PubMed, Web of Science, Scielo, and University of São Paulo Digital Library databases...
July 2017: Clinics
https://www.readbyqxmd.com/read/28793005/the-diagnostic-value-of-narrow-band-imaging-for-early-and-invasive-lung-cancer-a-meta-analysis
#2
Juanjuan Zhu, Wei Li, Jihong Zhou, Yuqing Chen, Chenling Zhao, Ting Zhang, Wenjia Peng, Xiaojing Wang
This study aimed to compare the ability of narrow-band imaging to detect early and invasive lung cancer with that of conventional pathological analysis and white-light bronchoscopy. We searched the PubMed, EMBASE, Sinomed, and China National Knowledge Infrastructure databases for relevant studies. Meta-disc software was used to perform data analysis, meta-regression analysis, sensitivity analysis, and heterogeneity testing, and STATA software was used to determine if publication bias was present, as well as to calculate the relative risks for the sensitivity and specificity of narrow-band imaging vs those of white-light bronchoscopy for the detection of early and invasive lung cancer...
July 2017: Clinics
https://www.readbyqxmd.com/read/28793004/abnormal-diastolic-function-underlies-the-different-beneficial-effects-of-cardiac-resynchronization-therapy-on-ischemic-and-non-ischemic-cardiomyopathy
#3
Qi Wang, Kang-Yu Chen, Fei Yu, Hao Su, Chun-Sheng An, Yang Hu, Dong-Mei Yang, Jian Xu, Ji Yan
OBJECTIVES: To investigate the association between diastolic function and the different beneficial effects of cardiac resynchronization therapy in patients with heart failure due to different causes. METHODS: The 104 enrolled patients were divided into an ischemic cardiomyopathy group (n=27) and a non-ischemic cardiomyopathy group (n=77) according to the cause of heart failure. Before implantation, left ventricular diastolic function was evaluated in all patients using echocardiography...
July 2017: Clinics
https://www.readbyqxmd.com/read/28793003/complete-axillary-dissection-without-drainage-for-the-surgical-treatment-of-breast-cancer-a-randomized-clinical-trial
#4
Ruffo Freitas-Junior, Luís Fernando Jubé Ribeiro, Marise Amaral Rebouças Moreira, Geraldo Silva Queiroz, Maurício Duarte Esperidião, Marco Aurélio Costa Silva, Rubens José Pereira, Rossana Araújo Catão Zampronha, Rosemar Macedo Sousa Rahal, Leonardo Ribeiro Soares, Danielle Laperche Dos Santos, Maria Virginia Thomazini, Cassiana Ferreira Silva de Faria, Régis Resende Paulinelli
OBJECTIVE: This randomized clinical trial evaluated the possibility of not draining the axilla following axillary dissection. METHODS: The study included 240 breast cancer patients who underwent axillary dissection as part of conservative treatment. The patients were divided into two groups depending on whether or not they were subjected to axillary drainage. ClinicalTrials.gov: NCT01267552. RESULTS: The median volume of fluid aspirated was significantly lower in the axillary drainage group (0...
July 2017: Clinics
https://www.readbyqxmd.com/read/28793002/laryngeal-tube-suction-for-airway-management-during-in-hospital-emergencies
#5
Haitham Mutlak, Christian Friedrich Weber, Dirk Meininger, Colleen Cuca, Kai Zacharowski, Christian Byhahn, Richard Schalk
OBJECTIVE: The role of supraglottic airway devices in emergency airway management is highlighted in international airway management guidelines. We evaluated the application of the new generation laryngeal tube suction (LTS-II/LTS-D) in the management of in-hospital unexpected difficult airway and cardiopulmonary resuscitation. METHODS: During a seven-year period, patients treated with a laryngeal tube who received routine anesthesia and had an unexpected difficult airway (Cormack Lehane Grade 3-4), who underwent cardiopulmonary resuscitation, or who underwent cardiopulmonary resuscitation outside the operating room and had a difficult airway were evaluated...
July 2017: Clinics
https://www.readbyqxmd.com/read/28793001/hypovitaminosis-d-in-patients-undergoing-kidney-transplant-the-importance-of-sunlight-exposure
#6
Cristiane F Vilarta, Marianna D Unger, Luciene M Dos Reis, Wagner V Dominguez, Elias David-Neto, Rosa M Moysés, Silvia Titan, Melani R Custodio, Mariel J Hernandez, Vanda Jorgetti
OBJECTIVES: Recent studies have shown a high prevalence of hypovitaminosis D, defined as a serum 25-hydroxyvitamin D level less than 30 ng/ml, in both healthy populations and patients with chronic kidney disease. Patients undergoing kidney transplant are at an increased risk of skin cancer and are advised to avoid sunlight exposure. Therefore, these patients might share two major risk factors for hypovitaminosis D: chronic kidney disease and low sunlight exposure. This paper describes the prevalence and clinical characteristics of hypovitaminosis D among patients undergoing kidney transplant...
July 2017: Clinics
https://www.readbyqxmd.com/read/28793000/intermittent-claudication-and-severe-renal-artery-stenosis-are-independently-associated-in-hypertensive-patients-referred-for-renal-arteriography
#7
Thiago Andrade Macedo, Luciano Ferreira Drager, Rodrigo Pinto Pedrosa, Henrique Cotchi Simbo Muela, Valeria Costa-Hong, Luiz Junia Kajita, Luiz Aparecido Bortolotto
OBJECTIVE: The purpose of this study was to evaluate the association between the presence of clinical symptoms of peripheral artery disease and severe renal artery stenosis in patients referred for renal angiography. METHOD: We included 82 patients with clinical suspicion of renovascular hypertension and performed an imaging investigation (renal Doppler ultrasound and/or renal scintigraphy) for possible renal artery stenosis. All patients underwent renal arteriography and were examined for peripheral artery disease based on the presence of intermittent claudication and ankle-brachial index test results...
July 2017: Clinics
https://www.readbyqxmd.com/read/28792999/clinical-features-of-refractory-ascites-in-outpatients
#8
Wanda Regina Caly, Rodrigo Martins Abreu, Bernardo Bitelman, Flair José Carrilho, Suzane Kioko Ono
OBJECTIVES: To present the clinical features and outcomes of outpatients who suffer from refractory ascites. METHODS: This prospective observational study consecutively enrolled patients with cirrhotic ascites who submitted to a clinical evaluation, a sodium restriction diet, biochemical blood tests, 24 hour urine tests and an ascitic fluid analysis. All patients received a multidisciplinary evaluation and diuretic treatment. Patients who did not respond to the diuretic treatment were controlled by therapeutic serial paracentesis, and a transjugular intrahepatic portosystemic shunt was indicated for patients who required therapeutic serial paracentesis up to twice a month...
July 2017: Clinics
https://www.readbyqxmd.com/read/28792998/validation-of-qf-pcr-for-prenatal-diagnoses-in-a-brazilian-population
#9
Renata Wendel de Moraes, Mario Henrique Burlacchini de Carvalho, Antonio Gomes de Amorim-Filho, Rossana Pulcineli Vieira Francisco, Renata Moscolini Romão, José Eduardo Levi, Marcelo Zugaib
OBJECTIVES: Quantitative fluorescence polymerase chain reaction (QF-PCR) is a rapid and reliable method for screening aneuploidies, but in Brazil, it is not used in public services. We investigated the accuracy of QF-PCR for the prenatal recognition of common aneuploidies and compared these results with cytogenetic results in our laboratory. METHOD: A ChromoQuant QF-PCR kit containing 24 primer pairs targeting loci on chromosomes 21, 13, 18, X and Y was employed to identify aneuploidies of the referred chromosomes...
July 2017: Clinics
https://www.readbyqxmd.com/read/28792997/hyoscine-butylbromide-for-colorectal-polyp-detection-prospective-randomized-placebo-controlled-trial
#10
Carlos Eduardo Oliveira Dos Santos, Hamilton Moreira, Julio Carlos Pereira-Lima, Carmen Australia Paredes Marcondes Ribas, Fernanda de Quadros Onófrio, Alexandre Eduardo Augusti Czecko, Rafael Koerich Ramos, Caroline Aragão de Carvalho
OBJECTIVES: The removal of pre-malignant colorectal lesions prevents cancer. Hyoscine has been proposed as a means of improving diagnosis by reducing colonic movements. The aim of this study was to analyze whether this anti-spasmodic enhances the detection of pre-malignant colorectal lesions. METHODS: In a randomized, double-blinded fashion patients received hyoscine or a saline solution in all consecutive colonoscopies in which the cecum was reached. Lesions were analysed with respect to number, size, location, histology and capillary pattern...
July 2017: Clinics
https://www.readbyqxmd.com/read/28658440/new-evidences-on-the-regulation-of-sf-1-expression-by-pod1-tcf21-in-adrenocortical-tumor-cells
#11
Monica Malheiros França, Antonio M Lerario, Maria Candida B V Fragoso, Claudimara Ferini Pacicco Lotfi
OBJECTIVES: Transcription Factor 21 represses steroidogenic factor 1, a nuclear receptor required for gonadal development, sex determination and the regulation of adrenogonadal steroidogenesis. The aim of this study was to investigate whether silencing or overexpression of the gene Transcription Factor 21 could modulate the gene and protein expression of steroidogenic factor 1 in adrenocortical tumors. METHODS: We analyzed the gene expression of steroidogenic factor 1 using qPCR after silencing endogenous Transcription Factor 21 in pediatric adrenal adenoma-T7 cells through small interfering RNA...
June 2017: Clinics
https://www.readbyqxmd.com/read/28658439/perioperative-management-of-drugs-commonly-used-in-patients-with-rheumatic-diseases-a-review
#12
André Silva Franco, Leandro Ryuchi Iuamoto, Rosa Maria Rodrigues Pereira
Rheumatic diseases are very prevalent, affecting about 7 million people in North America; they affect the musculoskeletal system, often with systemic involvement and potential for serious consequences and limitation on quality of life. Clinical treatment is usually long-term and includes drugs that are considered either simple or complex and are occasionally unknown to many health professionals who do not know how to manage these patients in emergency units and surgical wards. Thus, it is important for clinicians, surgeons and anesthesiologists who are involved with rheumatic patients undergoing surgery to know the basic principles of therapy and perioperative management...
June 2017: Clinics
https://www.readbyqxmd.com/read/28658438/effectiveness-and-safety-of-first-generation-protease-inhibitors-in-real-world-patients-with-hepatitis-c-virus-genotype-1-infection-in-brazil-a-multicenter-study
#13
Luciana Azevedo Callefi, Cristiane Alves Villela-Nogueira, Simone de Barros Tenore, Dimas Carnaúba-Júnior, Henrique Sérgio Moraes Coelho, Paulo de Tarso A Pinto, Letícia Cancella Nabuco, Mário Guimarães Pessoa, Maria Lucia Cardoso Gomes Ferraz, Paulo Roberto Abrão Ferreira, Ana de Lourdes Candolo Martinelli, Silvana Gama Florencio Chachá, Adalgisa de Souza Paiva Ferreira, Alessandra Porto de Macedo Bisio, Carlos Eduardo Brandão-Mello, Mário Reis Álvares-Da-Silva, Tânia Reuter, Claudia Alexandra Pontes Ivantes, Renata de Mello Perez, Maria Cássia Jacintho Mendes-Correa
OBJECTIVE: To evaluate the effectiveness and safety of first-generation protease inhibitors for the treatment of genotype 1 hepatitis C virus-infected patients at Brazilian reference centers. METHODS: This multicenter cross-sectional study included hepatitis C virus genotype 1 monoinfected patients treated with Peg-interferon, ribavirin, and either boceprevir (n=158) or telaprevir (n=557) between July 2013 and April 2014 at 15 reference centers in Brazil. Demographic, clinical, virological, and adverse events data were collected during treatment and follow-up...
June 2017: Clinics
https://www.readbyqxmd.com/read/28658437/indications-and-visual-outcomes-of-intrastromal-corneal-ring-segment-implantation-in-a-large-patient-series
#14
Taíse Tognon, Mauro Campos, João Paulo Wengrzynovski, Kleyton Arlindo Barella, Adriano Pasqualotti, Luiz Antônio de Brito Martins, Adriana Dos Santos Forseto, Luciene Barbosa de Sousa
OBJECTIVES: To describe the indications for and visual outcomes of intrastromal corneal ring segment implantation. METHODS: A large retrospective case-series chart-review study was conducted using Sorocaba Ophthalmological Hospital medical records. This study included 1222 eyes (1196 patients) that were surgically treated between November 2009 and December 2012. The following preoperative data were collected: age, gender, type of medical care and funding source, surgical technique, best-corrected visual acuity, manifest sphere and cylinder refractive error, maximum and minimum central keratometry, and pachymetry measurements of the cornea at the thinnest point and at the ring channel...
June 2017: Clinics
https://www.readbyqxmd.com/read/28658436/combined-aerobic-and-resistance-training-are-there-additional-benefits-for-older-hypertensive-adults
#15
Leandra G Lima, José T M Bonardi, Giulliard O Campos, Rodrigo F Bertani, Luria M L Scher, Júlio C Moriguti, Eduardo Ferriolli, Nereida K C Lima
OBJECTIVES: The objective of this study was to compare the effects of a combination of aerobic and resistance training to those of isolated aerobic training on blood pressure, body composition, and insulin sensitivity in hypertensive older adults. METHOD: Forty-four patients were randomly assigned to the aerobic group, resistance and aerobic group, and control group. Before and after 10 weeks, the following data were obtained: 24-hour ambulatory blood pressure data, abdominal circumference, waist circumference, body mass index, lean mass, fat mass, and insulin sensitivity...
June 2017: Clinics
https://www.readbyqxmd.com/read/28658435/sonographic-findings-of-the-bifid-median-nerve-and-persistent-median-artery-in-carpal-tunnel-a-preliminary-study-in-chinese-individuals
#16
Li Chen, Jie Chen, Bing Hu, Li-Xin Jiang
OBJECTIVE: The aim of this study was to investigate the prevalence of anatomic variations of the bifid median nerve, persistent median artery and persistent median vein in Chinese individuals and their relationship with carpal tunnel syndrome. METHODS: One hundred and sixty median nerves were examined using ultrasonography and colour Doppler ultrasonography. The location, shape, and size of the bifid median nerve, persistent median artery and persistent median vein were recorded...
June 2017: Clinics
https://www.readbyqxmd.com/read/28658434/language-assessment-of-children-with-severe-liver-disease-in-a-public-service-in-brazil
#17
Erica Macêdo de-Paula, Gilda Porta, Ana Cristina Aoun Tannuri, Uenis Tannuri, Debora Maria Befi-Lopes
OBJECTIVE: The aim of this research was to compare language development (expressive and receptive skills) in children awaiting liver transplantation with that of children who have already undergone the surgical procedure. METHODS: An observational, descriptive, cross-sectional study was conducted with 76 children divided into groups, as follows: 31 children who were candidates for liver transplantation (Group 1; G1), 45 children who had already undergone liver transplantation (Group 2; G2), and a control group (CG) of 60 healthy, normally developing children...
June 2017: Clinics
https://www.readbyqxmd.com/read/28658433/comparison-of-electrocardiographic-criteria-for-identifying-left-ventricular-hypertrophy-in-athletes-from-different-sports-modalities
#18
Nelson Samesima, Luciene Ferreira Azevedo, Luciana Diniz Nagem Janot De Matos, Leandro Santini Echenique, Carlos Eduardo Negrao, Carlos Alberto Pastore
OBJECTIVES: In athletes, isolated electrocardiogram high voltage criteria are widely used to evaluate left ventricular hypertrophy, but positive findings are thought to represent normal electrocardiogram alterations. However, which electrocardiogram criterion can best detect left ventricular hypertrophy in athletes of various sport modalities remains unknown. METHODS: Five electrocardiogram criteria used to detect left ventricular hypertrophy were tested in 180 male athletes grouped according to their sport modality: 67% low-static and high-dynamic components and 33% high-static and high-dynamic components of exercise...
June 2017: Clinics
https://www.readbyqxmd.com/read/28658432/predictors-of-micro-costing-components-in-liver-transplantation
#19
Luciana Bertocco de Paiva Haddad, Liliana Ducatti, Luana Regina Baratelli Carelli Mendes, Wellington Andraus, Luiz Augusto Carneiro D'Albuquerque
OBJECTIVES: Although liver transplantation procedures are common and highly expensive, their cost structure is still poorly understood. This study aimed to develop models of micro-costs among patients undergoing liver transplantation procedures while comparing the role of individual clinical predictors using tree regression models. METHODS: We prospectively collected micro-cost data from patients undergoing liver transplantation in a tertiary academic center. Data collection was conducted using an Intranet registry integrated into the institution's database for the storing of financial and clinical data for transplantation cases...
June 2017: Clinics
https://www.readbyqxmd.com/read/28658431/influence-of-the-prone-position-on-a-stretcher-for-pregnant-women-on-maternal-and-fetal-hemodynamic-parameters-and-comfort-in-pregnancy
#20
Claudia Oliveira, Marco Antonio Borges Lopes, Agatha Sacramento Rodrigues, Marcelo Zugaib, Rossana Pulcineli Vieira Francisco
OBJECTIVES: To analyze the influence of lying in prone position on a specially designed stretcher on the maternal-fetal hemodynamic parameters and comfort of pregnant women. METHODS: A randomized, controlled trial with 33 pregnant women divided into 2 groups: pregnant group sequence 1 and pregnant group sequence 2. The order of positions used in sequence 1 was Fowler's position, prone position, supine position, left lateral, Fowler's position 2, supine position 2, prone position 2 and left lateral 2...
June 2017: Clinics
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