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Alexandre F Machado, Alexandre L Evangelista, João Marcelo Q Miranda, Cauê V La Scala Teixeira, Roberta Luksevicius Rica, Charles R Lopes, Aylton Figueira-Júnior, Julien S Baker, Danilo S Bocalini
OBJECTIVES: To describe external training load and internal training load through sets of a single session of high-intensity interval training (HIIT) body work. METHODS: Twenty male individuals (24±3 years) performed a HIIT body work protocol consisting of a single bout of exercise with 1:1 stimuli. The exercises used were 30 min in duration with "all-out" intensity. The exercises included jumping jacks, mountain climbers, burpees and squat jumps, totaling 20 min of exercise...
October 29, 2018: Clinics
Patricia Rehder-Santos, Vinicius Minatel, Bruno Araújo Ribeiro, Richard Ducatti, Silvia Cristina Garcia de Moura-Tonello, Meliza Goi Roscani, Michel da Silva Reis, Ester Silva, Aparecida Maria Catai
OBJECTIVE: The objective of this study was to investigate the interaction among the determinants of expiratory flow limitation (EFL), peak oxygen uptake (VO2peak), dysanapsis ratio (DR) and age during cycling at different intensities in young and middle-aged men. METHODS: Twenty-two (11 young and 11 middle-aged) men were assessed. Pulmonary function tests (DR), cardiopulmonary exercise tests (VO2peak) and two constant load tests (CLTs) at 75% (moderate intensity) and 125% (high intensity) of the gas exchange threshold were performed to assess EFL...
October 29, 2018: Clinics
Viviane Angelina de Souza, Dílmerson Oliveira, Eduardo Neumann Cupolilo, Carolina Souza Miranda, Fernando Antônio Basile Colugnati, Henrique Novais Mansur, Natália Maria da Silva Fernandes, Marcus Gomes Bastos
OBJECTIVES: We evaluated the validity and reliability of ultrasonography measurement of rectus femoris cross-sectional area compared to computed tomography in patients in pre-dialysis chronic kidney disease and analyzed the association between these measurements and the diagnosis of sarcopenia. METHODS: One hundred patients with nondialysis chronic kidney disease were evaluated. Sarcopenia was defined using the criteria of the Foundation for the National Institutes of Health Sarcopenia Project (FNIH)...
October 29, 2018: Clinics
Heraldo Carlos Borges Inforzato, Adriana Aparecida Ferraz Carbonel, Ricardo Santos Simões, Gisela Rodrigues da Silva Sasso, Patricia Daniele Azevedo Lima, José Maria Soares-Júnior, Lydia Masako Ferreira, Manuel de Jesus Simões
OBJECTIVES: The aim of this study was to evaluate the histomorphometry of the skin of women during the reproductive period according to the Fitzpatrick classification. METHODS: Thirty women aged 30 to 45 years were included in this study. We studied the surgical sites of extracted nevi. The material was processed for routine histology and then stained with haematoxylin and eosin as well as Picrosirius red. Four-micrometre histological sections were analysed according the Fitzpatrick criteria (skin pigmentation)...
October 29, 2018: Clinics
Fabiola Del Carlo Bernardi, Marcela Del Carlo Bernardi, Teresa Takagaki, Sheila Aparecida Coelho Siqueira, Marisa Dolhnikoff
OBJECTIVES: Advancements in non-small cell lung cancer treatment based on targeted therapies have made the differentiation between adenocarcinoma and squamous cell carcinoma increasingly important. Pathologists are challenged to make the correct diagnosis in small specimens. We studied the accuracy of an immunohistochemical panel in subclassifying non-small cell lung cancer in routine small biopsies and compared the results with the diagnosis from resected lung specimens, autopsy samples or biopsied/resected metastases...
October 29, 2018: Clinics
Cristina Prata Amendola, João Manoel Silva-Jr, Taisa Carvalho, Luciana Coelho Sanches, Ulysses Vasconcelos de Andrade E Silva, Rosana Almeida, Emmanuel Burdmann, Emerson Lima, Fabiana Ferreira Barbosa, Renata Souza Ferreira, Maria José C Carmona, Luiz Marcelo Sá Malbouisson, Fernando A M Nogueira, José Otavio Costa Auler-Júnior, Suzana Margareth Lobo
OBJECTIVES: Acute kidney injury is associated with many conditions, and no interventions to improve the outcomes of established acute kidney injury have been developed. We performed this study to determine whether goal-directed therapy conducted during the early stages of acute kidney injury could change the course of the disease. METHODS: This was a multicenter prospective randomized controlled study. Patients with early acute kidney injury in the critical care unit were randomly allocated to a standard care (control) group or a goal-directed therapy group with 8h of intensive treatment to maximize oxygen delivery, and all patients were evaluated during a period of 72h...
October 29, 2018: Clinics
Paula Caitano Fontela, Thiago Costa Lisboa, Luiz Alberto Forgiarini-Júnior, Gilberto Friedman
OBJECTIVES: To assess early mobilization practices of mechanically ventilated patients in southern Brazilian intensive care units (ICUs) and to identify barriers associated with early mobilization and possible complications. METHODS: A prospective, observational, multicenter, 1-day point-prevalence study was conducted across 11 ICUs and included all mechanically ventilated adult patients. Hospital and ICU characteristics and patients' demographic data, the highest level of mobilization achieved in the 24 hours prior to the survey and related barriers, and complications that occurred during mobilization were collected in the hospital and the ICU...
October 29, 2018: Clinics
Amanda Favaro Cagnolati, Marcel Nader, Marcello Henrique Nogueira-Barbosa, Claudio Henrique Barbieri
OBJECTIVES: The aim of this study was to perform ultrasonographic characterization of the normal ulnar collateral ligament in different age groups and compare it in men and women and in dominant and nondominant hands. METHODS: Forty right-handed volunteers in the age groups 20-30, 31-40, 41-50, and 51-60 years without a history of trauma or surgical procedure in the studied joint were evaluated. The studied parameters were ligament length, greatest ligament thickness, ligament longitudinal section area in the longitudinal plane, distance from the aponeurosis of the adductor muscle to the metacarpal head surface and joint opening at rest and under abduction stress...
October 29, 2018: Clinics
Natália Bonissi Gonçalves, Rafael Ferraz Bannitz, Bruna Ramos Silva, Danielle Duran Becari, Carolina Poloni, Patrícia Moreira Gomes, Milton Cesar Foss, Maria Cristina Foss-Freitas
OBJECTIVES: Dietary omega-3 fatty acids have been efficacious in decreasing serum cholesterol levels and reducing the risk of cardiovascular disease. However, the metabolic and molecular changes induced by the omega-3 fatty acid α-linolenic acid (ALA), which is found in linseed oil, are not fully understood. In this study, we showed a correlation between ALA and insulin resistance, inflammation and endoplasmic reticulum stress (ERS). METHODS: We studied 40 male mice (C57/BL6) divided into 4 groups: a control (C) group, a control + omega-3/ALA (CA) group, a high-fat diet (HFD) (H) group and a high-fat diet + omega-3/ALA (HA) group...
October 29, 2018: Clinics
Ana Cristina Aoun Tannuri, Ĺtalo Geraldo Rotondo, Guilherme Garcia Barros, Victor Van Vaisberg, Cícero Mendes-Neto, Vitor Ribeiro Paes, Maria Cecilia Mendonça Coelho, Josiane Gonçalves, Suellen Serafini, Uenis Tannuri
OBJECTIVES: The purpose of this study was to present an experimental model of short bowel syndrome (SBS) in weaning rats and to compare the adaptative mechanisms of the remaining bowel in weaning rats and adult animals by means of morphometric, histologic and molecular methods. METHODS: Twenty-four weaning rats were divided into 3 groups of 8 animals, one control group and two short bowel groups (euthanasia after 4 and 21 days), and were compared with similar adult groups...
October 18, 2018: Clinics
José Roosevelt Cavalcante, Luiz Gonzaga Porto Pinheiro, Paulo Roberto Carvalho de Almeida, Márcia Valéria Pitombeira Ferreira, Gizele Almada Cruz, Thales Alves Campelo, Caroliny Soares Silva, Luana Nepomuceno Gondim Costa Lima, Bruno Masato Kitagawa de Oliveira, Lara Mulato Lima, Laura Magda Costa Feitosa, Agostinho Câmara Pinheiro, Cristiane Cunha Frota
OBJECTIVE: The aim of this study is to investigate the presence of human papillomavirus DNA and genotypes in breast cancer and normal breast tissue samples obtained from women from the northeast region of Brazil. METHOD: One hundred three breast cancer samples and 95 normal breast samples, as the non-malignant controls, were studied. DNA extraction was verified by human beta-globin gene amplification, and polymerase chain reaction was conducted based on HPV L1-specific consensus primers MY09/MY11 and GP5+/GP6+, followed by nested multiplex polymerase chain reaction with type-specific primers for the E6/E7 consensus region...
October 18, 2018: Clinics
Ligia Fidelis Ivanovic, Bruno C Silva, Arnaldo Lichtenstein, Edison Ferreira de Paiva, Maria Lucia Bueno-Garcia
OBJECTIVES: To describe clinical complications related to colonoscopy in inpatients with multiple diseases. Among the known complications, acute kidney injury was the primary focus. METHODS: This was an observational retrospective study of 97 inpatients. Data relating to age; gender; comorbidities; current medication; blood tests (renal function, blood glucose and LDL cholesterol levels); length of hospital stay; indication, results, and complications of colonoscopies; and time to the development of kidney injury were collected between June 2011 to February 2012...
October 18, 2018: Clinics
Christina Eder-Czembirek, Sascha Rechinger, Gabriela Kornek, Edgar Selzer, Rudolf Seemann
OBJECTIVES: This retrospective study performed a comprehensive analysis of the usage of intra-arterial chemotherapy (iaCh) for locally recurrent UICC stage IV oral squamous cell carcinoma (OSCC) over two decades at the Department of Cranio-Maxillofacial and Oral Surgery at the University Hospital Vienna to assess the utility of its future use. METHODS: Between 1994 and 2014, iaCh was indicated in 48 OSCC cases. In these, the two most frequent iaCh schemes, cisplatin/5-fluorouracil (Cis/5-FU) and methotrexate/bleomycin (MTX/Bleo), were chosen for further analysis...
October 18, 2018: Clinics
João Guilherme Tavares Marchiori, Fabio P Saraiva, Liliane C G da Silva, Jessica B Garcia, Juliano C M Pina
OBJECTIVES: The function of a medical expert within the scope of the Brazilian social security system consists of medically evaluating the examinee to draw a conclusive opinion on the person's working ability capacity and to characterize the disability for social security and assistance purposes. Forensic decisions inevitably converge on two opposite outcomes: concession or refusal. Rejection is against the interests of the candidates, who can direct their disappointment and dissatisfaction at the professional, exposing the latter to potentially stressful situations...
October 18, 2018: Clinics
Daniela W Gancz, Maristela T Cunha, Claudio Leone, Joaquim C Rodrigues, Fabíola V Adde
OBJECTIVES: The current study sought to evaluate the quality of life of young patients with cystic fibrosis and correlate these results with the clinical parameters indicative of disease severity. METHODS: This cross-sectional study applied the validated Portuguese version of a cystic fibrosis specific quality of life questionnaire to clinically stable patients aged 14 to 21 years old. The correlations between the questionnaire domain scores and forced expiratory volume in one second (FEV1) values, the Shwachman-Kulczycki score, and body mass index were assessed, and correlations were considered as significant when p<0...
October 18, 2018: Clinics
Janaína Campos Senra, Mariana Azevedo Carvalho, Agatha Sacramento Rodrigues, Vera Lúcia Jornada Krebs, Maria Augusta Bento Cicaroni Gibelli, Rossana Pulcineli Vieira Francisco, Lisandra Stein Bernardes
Since studies show that an unfavorable environment during intrauterine development predisposes individuals to several diseases in adulthood, our objective is to assess the relation between fetal growth restriction and chronic renal disease in adults. We searched four different electronic databases through November 2017: CENTRAL, EMBASE, LILACS and MEDLINE. We selected studies with longitudinal or transversal designs associating kidney function in adulthood with low birth weight. Two reviewers evaluated the inclusion criteria and the risk of bias and extracted data from the included papers...
October 18, 2018: Clinics
Gustavo O Silva, Breno Q Farah, Antonio H Germano-Soares, Aluísio Andrade-Lima, Fabio S Santana, Sérgio Lc Rodrigues, Raphael M Ritti-Dias
OBJECTIVE: The present study analyzed blood pressure responses after a single session of isometric handgrip exercise performed with different volumes and intensities by patients with hypertension. METHODS: This randomized crossover trial submitted 12 hypertensive patients (58±5 years old) to four isometric handgrip exercise sessions in a random order: 4 x 2 min at 30% of the maximal voluntary contraction (S30%); 4 x 2 min at 50% of the maximal voluntary contraction (S50%2min); 4 x 3 min at 30% of the maximal voluntary contraction (S30%3min); and a control session...
October 18, 2018: Clinics
Eliane Azeka Hase, Venina Isabel Poço Viana Leme de Barros, Ana Maria Kondo Igai, Rossana Pulcinelli Vieira Francisco, Marcelo Zugaib
OBJECTIVES: Hospitalized patients with cancer are at high risk of developing venous thromboembolism, and the risk increases with pregnancy. The aim of this study was to apply a thromboprophylaxis protocol with a venous thromboembolism risk score for hospitalized pregnant women with cancer and to evaluate the effects on maternal morbidity and mortality. METHODS: A longitudinal and prospective study was conducted from December 2014 to July 2016. The venous thromboembolism risk score was modified from the guidelines of the Royal College of Obstetricians and Gynaecologists...
October 18, 2018: Clinics
Sandra Trindade Low, Ana Paula Costa Rodrigues Ferraz, Regiane Maio, Fabiane Valentini Francisqueti, Damiana Tortolero Pierine, Weidylla Natália Silva Borges, Ariel Dandara de Carvalho, Gedalva Pereira de Lima, Ana Lúcia A Ferreira, Klinsmann Carolo Dos Santos, Camila Renata Corrêa
OBJECTIVE: The aim of the present study was to investigate the association of the redox state via malondialdehyde (MDA) as a lipid peroxidation biomarker and hydrophilic antioxidant capacity (HAC) with dietary, anthropometric, demographic, socio-economic and clinical variables as well as the serum concentrations of vitamins in children aged 20-36 months. This cross-sectional study was conducted from May 2013 to May 2014 and included a total of 100 children. METHODS: The variables studied included anthropometric measurements, dietary intake by the Food Frequency Questionnaire (FFQ), socio-demographic features, clinical attributes, serum redox status, and serum vitamin concentrations...
October 18, 2018: Clinics
Tomoyuki Harada, Mitchell Fink, Ruy J Cruz
OBJECTIVES: Several compounds characterized by an olefin linkage conjugated to a carbonyl group have anti-inflammatory properties. The diuretic ethacrynic acid (EA) is a compound of this type. Herein, we tested the hypothesis that ethacrynic acid can modulate the development of ileus after bowel manipulation. METHODS: Groups (n=9) of male C57Bl/6 mice underwent surgical manipulation of the small intestine using a pair of cotton-tipped applicators (MAN). Control animals (CONT) did not undergo any surgical intervention or receive treatment...
October 18, 2018: Clinics
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