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Allergy, Asthma, and Clinical Immunology

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https://www.readbyqxmd.com/read/29755533/new-onset-colitis-in-an-adult-patient-with-chronic-granulomatous-disease-treated-with-hematopoietic-stem-cell-transplantation-a-diagnostic-dilemma
#1
Kara Robertson, Stephen Couban, Desmond Leddin, Imran Ahmad, Lori Connors
Background: Chronic granulomatous disease (CGD) is a rare primary immunodeficiency characterized by recurrent life-threatening bacterial and fungal infections, granuloma formation and intestinal disease. This disease is caused by defects in NADPH oxidase, which result in the inability of phagocytes (neutrophils, monocytes and macrophages) to destroy certain microbes. The only established curative therapy for CGD is hematopoietic stem cell transplantation. Case presentation: A 23-year-old Caucasian male with X-linked chronic granulomatous disease underwent a reduced-intensity conditioning, matched unrelated donor peripheral blood stem cell transplant, after which he was started on tacrolimus and mycophenolate for graft-versus-host disease prophylaxis...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29743896/investigating-the-effectiveness-of-the-trigonella-foenum-graecum-l-fenugreek-seeds-in-mild-asthma-a-randomized-controlled-trial
#2
Majid Emtiazy, Laleh Oveidzadeh, Minoo Habibi, Leila Molaeipour, Daryush Talei, Zahra Jafari, Mahmoud Parvin, Mohammad Kamalinejad
Background: Asthma is one of the important chronic diseases. The asthma prevalence is increasing in last decades. Despite the presence of good controller drugs like corticosteroids, about 60% of asthmatic patients use alternative medicine. This study was done to determine the effectiveness of Tregonella foenum graceum (fenugreek) seeds in mild asthma. Methods: It is a double blind trial with placebo effect. One of the ancient prescriptions from Persian Medicine was selected...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29713354/severe-eosinophilic-asthma-in-primary-care-in-canada-a-longitudinal-study-of-the-clinical-burden-and-economic-impact-based-on-linked-electronic-medical-record-data
#3
Don Husereau, Jason Goodfield, Richard Leigh, Richard Borrelli, Michel Cloutier, Alain Gendron
Background: Stratification of patients with severe asthma by blood eosinophil counts predicts responders to anti-interleukin (IL)-5 (mepolizumab and reslizumab) and anti-IL-5 receptor α (benralizumab) therapies. This study characterized patients with severe asthma who could qualify for these biologics in a primary care setting. Methods: We retrospectively selected patients from July 1, 2010, to June 30, 2014, using a linked electronic medical records (EMR) database (IMS Evidence 360 EMR Canada) for > 950,000 patients in primary care in Ontario, Canada...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29692816/the-course-of-asthma-during-pregnancy-in-a-recent-multicase-control-study-on-respiratory-health
#4
A Grosso, F Locatelli, E Gini, F Albicini, C Tirelli, I Cerveri, A G Corsico
Background: Over the years it has been widely stated that approximately one-third of asthmatic women experience worsening of the disease during pregnancy. However, the literature has not been reviewed systematically and the meta-analytic reviews include old studies. This study aimed to examine whether the prevalence of worsening asthma during pregnancy is still consistent with prior estimate or it has been reduced. Methods: A detailed Clinical Questionnaire on respiratory symptoms, medical history, medication, use of services, occupation, social status, home environment and lifestyle was administered to random samples of the Italian population in the frame of the Gene Environment Interactions in Respiratory Diseases (GEIRD) study...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29643919/an-update-on-molecular-cat-allergens-fel-d-1-and-what-else-chapter-1-fel-d-1-the-major-cat-allergen
#5
REVIEW
B Bonnet, K Messaoudi, F Jacomet, E Michaud, J L Fauquert, D Caillaud, B Evrard
Background: Cats are the major source of indoor inhalant allergens after house dust mites. The global incidence of cat allergies is rising sharply, posing a major public health problem. Ten cat allergens have been identified. The major allergen responsible for symptoms is Fel d 1, a secretoglobin and not a lipocalin, making the cat a special case among mammals. Main body: Given its clinical predominance, it is essential to have a good knowledge of this allergenic fraction, including its basic structure, to understand the new exciting diagnostic and therapeutic applications currently in development...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29632547/critical-view-of-anaphylaxis-epidemiology-open-questions-and-new-perspectives
#6
REVIEW
Luciana Kase Tanno, Ana Luiza Bierrenbach, F Estelle R Simons, Victoria Cardona, Bernard Yu-Hor Thong, Nicolas Molinari, Moises A Calderon, Margitta Worm, Yoon-Seok Chang, Nikolaos G Papadopoulos, Thomas Casale, Pascal Demoly
In contrast to the majority of allergic or hypersensitivity conditions, worldwide anaphylaxis epidemiological data remain sparse with low accuracy, which hampers comparable morbidity statistics. Data can differ widely depending on a number of variables. In the current document we reviewed the forms on which anaphylaxis has been defined and classified; and how it can affect epidemiological data. With regards to the methods used to capture morbidity statistics, we observed the impact of the anaphylaxis coding utilizing the World Health Organization's International Classification of Diseases...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29619062/immediate-type-hypersensitivity-and-late-phase-reaction-occurred-consecutively-in-a-patient-receiving-ethambutol-and-levofloxacin
#7
Yukihiko Kato, Yu Sato, Miho Nakasu, Ryoji Tsuboi
Background: We experienced a rare case of immediate type hypersensitivity and late phase reaction to anti-tubercular therapy consisting of ethambutol and levofloxacin, which occurred in close succession, giving the appearance of a single, continuous reaction to one drug. Case presentation: The patient was a man in his 70's who began therapy consisting of isoniazide, rifampicin, and ethambutol for pulmonary tuberculosis. Since the patient had a drug eruption within several hours after the start of his treatment, his reaction to ethambutol was assessed first among the three suspected drugs using an oral challenge test...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29599802/tuberculosis-induced-autoimmune-haemolytic-anaemia-a-systematic-review-to-find-out-common-clinical-presentations-investigation-findings-and-the-treatment-options
#8
REVIEW
Devarajan Rathish, Sisira Siribaddana
Background: Tuberculosis induced autoimmune haemolytic anaemia is a rare entity. The aim of this study was to explore its common presentations, investigation findings and treatment options through a systematic review of published reports. Methods: PubMed, Trip, Google Scholar, Science Direct, Cochrane Library, Open-Grey, Grey literature report and the reference lists of the selected articles were searched for case reports in English on tuberculosis induced auto-immune haemolytic anaemia...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29560020/cytokine-profiles-among-patients-co-infected-with-plasmodium-falciparum-malaria-and-soil-borne-helminths-attending-kampala-international-university-teaching-hospital-in-uganda
#9
Richard Bwanika, Charles D Kato, Johnson Welishe, Daniel C Mwandah
Background: Malaria and helminths share the same geographical distribution in tropical Africa. Studies of the interaction of helminth and malaria co-infection in humans have been few and are mainly epidemiological, with little information on cellular immune responses. This study aimed to determine Cytokine profiles among patients co-infected with Plasmodium falciparum malaria and soil borne helminth attending Kampala International University Teaching Hospital (KIU). Methods: A case control study of 240 patients were recruited at KIU teaching hospital...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29545827/a-novel-outpatient-desensitization-protocol-for-recombinant-human-erythropoietin-allergy-in-a-pediatric-patient
#10
Jaime S Rosa, Van B Vuong, Orly Haskin, Anne Y Liu
Background: Recombinant human erythropoietin, such as epoetin alfa and darbepoetin alfa, is an important therapy for anemia due to chronic renal failure. Allergy to recombinant human erythropoietin and the need for desensitization are rare. Case presentation: We report here a novel epoetin alfa outpatient desensitization protocol in a girl who developed delayed cutaneous hypersensitivity to subcutaneous epoetin alfa and intravenous darbepoetin alfa. An initial attempt at traditional epoetin alfa desensitization failed, so we created a slower 17-day outpatient desensitization that succeeded and allowed treatment continuation...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29507584/clinical-implications-of-cd4-t-cell-subsets-in-adult-atopic-asthma-patients
#11
Matthew Wiest, Katherine Upchurch, Wenjie Yin, Jerome Ellis, Yaming Xue, Bobby Lanier, Mark Millard, HyeMee Joo, SangKon Oh
Background: T cells play a central role in chronic inflammation in asthma. However, the roles of individual subsets of T cells in the pathology of asthma in patients remain to be better understood. Methods: We investigated the potential signatures of T cell subset phenotypes in asthma using fresh whole blood from adult atopic asthma patients (n = 43) and non-asthmatic control subjects (n = 22). We further assessed their potential clinical implications by correlating asthma severity...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29492095/evaluation-of-eczema-asthma-allergic-rhinitis-and-allergies-among-the-grade-1-children-of-iqaluit
#12
Ahmed Ahmed, Amir Hakim, Allan Becker
Background: Little is known about the prevalence of asthma, allergic rhinitis, eczema and allergies among Canadian Inuit children, especially those living in the arctic and subarctic areas. Methods: A cross-sectional study among Grade 1 students attending schools in Iqaluit, the capital of Nunavut, was conducted during the 2015/2016 school year. We used the International Study of Allergy and Asthma in Children questionnaire with added questions relevant to the population...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29449864/seasonal-variation-in-circulating-group-2-innate-lymphoid-cells-in-mugwort-allergic-asthmatics-during-and-outside-pollen-season
#13
Qing Miao, Yan Wang, Yong-Ge Liu, Yi-Xin Ren, Hui Guan, Zhen Li, Wei Xu, Li Xiang
Background: Group 2 innate lymphoid cells (ILC2s) are a newly identified cell population with the potent capability to produce Th2-type cytokines in a non-antigen specific manner. Previous study demonstrated that enhanced circulating ILC2s in cat-allergic patient after experimental allergen challenge, whereas the effects of natural allergen exposure on peripheral ILC2s are still unclear. We therefore examined the variations in circulating ILC2s among asthmatic patients sensitized to different allergens in- and outside- pollen season...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29434645/atopy-and-related-clinical-symptoms-among-swiss-medical-students-from-2007-to-2015
#14
Lukas Steinegger, Stephan Regenass, Lucas M Bachmann, Elsbeth Probst, Urs C Steiner
Background: Atopic allergy is a widespread disease with increasing prevalence in the second half of the twentieth century and is most often associated with clinical symptoms, like rhinoconjunctivitis, asthma or eczema. This study explored the prevalence of atopy and polysensitization in nine cohorts of Swiss medical students during the period of 2007-2015. Furthermore, the self-reported allergic symptoms, such as rhinoconjunctivitis, asthma and eczema, among students with and without atopy were assessed...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29434644/self-reported-questionnaire-survey-on-the-prevalence-and-symptoms-of-adverse-food-reactions-in-patients-with-chronic-inhalant-diseases-in-tangshan-city-china
#15
Guodong Hao, Xuxin Lai, Zhijing Song, Zhixing Wang, Xing-Ai Kong, Haifeng Zhong, Sui Fu Hui, Yiwu Zheng
Background: The prevalence of adverse food reactions in patients with chronic inhalant diseases has seldom been studied in China. This study is to investigate the prevalence of adverse food reactions and the symptoms caused in respiratory patients. Methods: Respiratory patients in allergy clinics were asked to complete a questionnaire. Patients' information such as age, gender, family history of allergy, and adverse reactions to a list of 48 foods and the symptoms caused, was recorded...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29371864/onset-of-action-for-loratadine-tablets-for-the-symptomatic-control-of-seasonal-allergic-rhinitis-in-adults-challenged-with-ragweed-pollen-in-the-environmental-exposure-unit-a-post-hoc-analysis-of-total-symptom-score
#16
Mark W Tenn, Lisa M Steacy, Charlene C Ng, Anne K Ellis
Background: Loratadine is a second-generation, non-sedating antihistamine used for the relief of allergic rhinitis symptoms. Previous studies reported that when loratadine was encapsulated, the onset of action for symptom relief was 180 min. However, unmodified loratadine tablets were not evaluated at that time. Using data from a previously published Environmental Exposure Unit (EEU) study comparing azelastine nasal spray with loratadine tablets, cetirizine tablets, and placebo, this post hoc analysis determines the onset of action of loratadine tablets (i...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29339956/csaci-position-statement-prescribing-sublingual-immunotherapy-tablets-for-aeroallergens
#17
REVIEW
J Quirt, R Gagnon, A K Ellis, H L Kim
No abstract text is available yet for this article.
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29308071/positive-correlation-of-airway-resistance-and-serum-asymmetric-dimethylarginine-adma-in-bronchial-asthma-patients-lacking-evidence-for-systemic-inflammation
#18
Gabor Tajti, Csaba Papp, Laszlo Kardos, Sandor Keki, Krisztian Pak, Magdolna Emma Szilasi, Rudolf Gesztelyi, Angela Mikaczo, Andrea Fodor, Maria Szilasi, Judit Zsuga
Background: Contribution of nitric-oxide (NO) pathway to the pathogenesis of bronchial asthma (asthma) is ambiguous as NO may confer both protective and detrimental effects depending on the NO synthase (NOS) isoforms, tissue compartments and underlying pathological conditions (e.g. systemic inflammation). Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor and uncoupler of NOS with distinct selectivity for NOS isoforms. In a cross-sectional study, we assessed whether ADMA is an independent predictor of airway resistance (Raw ) in therapy-controlled asthma...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29296108/feasibility-of-sustained-response-through-long-term-dosing-in-food-allergy-immunotherapy
#19
Sandra Andorf, Monali Manohar, Tina Dominguez, Whitney Block, Dana Tupa, Rohun A Kshirsagar, Vanitha Sampath, R Sharon Chinthrajah, Kari C Nadeau
Background: Clinical trials using oral immunotherapy (OIT) for the treatment of food allergies have shown promising results. We previously demonstrated the feasibility of desensitization for up to 5 food allergens simultaneously through OIT. In this observational study, we report the findings of long-term follow-up (LTFU) of the participants treated through a single site OIT phase 1 trial. Methods: The participants (n = 46) were followed up to 72 months since the time they reached 2 g maintenance dose per food in the initial phase 1 trial...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29296107/observational-long-term-follow-up-study-of-rapid-food-oral-immunotherapy-with-omalizumab
#20
Sandra Andorf, Monali Manohar, Tina Dominguez, Whitney Block, Dana Tupa, Rohun A Kshirsagar, Vanitha Sampath, R Sharon Chinthrajah, Kari C Nadeau
Background: A number of clinical studies focused on treating a single food allergy through oral immunotherapy (OIT) with adjunctive omalizumab treatment have been published. We previously demonstrated safety and tolerability of a rapid OIT protocol using omalizumab in a phase 1 study to achieve desensitization to multiple (up to 5) food allergens in parallel, rapidly (7-36 weeks; median = 18 weeks). In the current long-term, observational study, we followed 34 food allergic participants for over 5 years, who had originally undergone the phase 1 rapid OIT protocol...
2017: Allergy, Asthma, and Clinical Immunology
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