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Allergy, Asthma, and Clinical Immunology

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https://www.readbyqxmd.com/read/28077947/asthma-and-the-microbiome-defining-the-critical-window-in-early-life
#1
REVIEW
Leah T Stiemsma, Stuart E Turvey
Asthma is a chronic inflammatory immune disorder of the airways affecting one in ten children in westernized countries. The geographical disparity combined with a generational rise in prevalence, emphasizes that changing environmental exposures play a significant role in the etiology of this disease. The microflora hypothesis suggests that early life exposures are disrupting the composition of the microbiota and consequently, promoting immune dysregulation in the form of hypersensitivity disorders. Animal model research supports a role of the microbiota in asthma and atopic disease development...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28070196/airway-autoimmune-responses-in-severe-eosinophilic-asthma-following-low-dose-mepolizumab-therapy
#2
Manali Mukherjee, Hui Fang Lim, Sruthi Thomas, Douglas Miller, Melanie Kjarsgaard, Bruce Tan, Roma Sehmi, Nader Khalidi, Parameswaran Nair
BACKGROUND: Anti-interleukin (IL)-5 monoclonal antibodies as an eosinophil-depleting strategy is well established, with Mepolizumab being the first biologic approved as an adjunct treatment for severe eosinophilic asthma. CASE PRESENTATION: A 62-year old woman diagnosed with severe eosinophilic asthma showed poor response to Mepolizumab therapy (100 mg subcutaneous dose/monthly) and subsequent worsening of symptoms. The treatment response to Mepolizumab was monitored using both blood and sputum eosinophil counts...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27999603/polyethylene-glycol-as-a-cause-of-anaphylaxis
#3
Katharina Wylon, Sabine Dölle, Margitta Worm
BACKGROUND: Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food. CASE REPORT: We report on a Caucasian patient experiencing recurrent severe allergic reactions to several drugs. An extensive diagnostic workup including skin prick tests, intradermal tests (IDT) and a double-blind oral challenge was performed to identify the trigger of anaphylaxis. In the present case hypersensitivity to the additive polyethylene glycol was confirmed by an IDT suggesting an Immunoglobulin E-dependent mechanism as a cause of the reaction...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27999602/anaphylaxis-to-supplemental-oral-lactase-enzyme
#4
M R Voisin, R Borici-Mazi
BACKGROUND: Anaphylactic reactions involving IgE mediated hypersensitivity have been frequently reported for a number of uncommon foods. However, cases of anaphylaxis to over the counter vitamins and oral supplements have been rarely published. Lactose intolerance affects approximately 20% of Canadians and roughly 70% of the world's population of any age. Lactose intolerance develops primarily due to the absence of the enzyme lactase and treatment involves avoidance of lactose-containing foods or ingestion of commercially available lactase enzyme preparations prior to their consumption...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27980540/comprehensive-genetic-testing-for-primary-immunodeficiency-disorders-in-a-tertiary-hospital-10-year-experience-in-auckland-new-zealand
#5
See-Tarn Woon, Rohan Ameratunga
BACKGROUND AND PURPOSE: New Zealand is a developed geographically isolated country in the South Pacific with a population of 4.4 million. Genetic diagnosis is the standard of care for most patients with primary immunodeficiency disorders (PIDs). METHODS: Since 2005, we have offered a comprehensive genetic testing service for PIDs and other immune-related disorders with a published sequence. Here we present results for this program, over the first decade, between 2005 and 2014...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27980539/aspergillus-march-from-abpa-to-aspergilloma-to-subacute-invasive-aspergillosis
#6
Vikas Dogra, Ankit Kumar Sinha, Rajat Saxena, Deepak Talwar
BACKGROUND: Aspergillus is a ubiquitous fungus responsible for allergic as well as saprophytic and invasive manifestations depending on host's immune status. The following case report demonstrates progression of allergic manifestations of Aspergillus to its invasive form in an individual with decreasing immunity. This can lead to uncertainties in diagnosis and management. CASE PRESENTATION: A 28-year-old male, non smoker, known case of ABPA (allergic bronchopulmonary aspergillosis) was admitted with complaints of cough for 1 month, associated with recurrent episodes of hemoptysis for last 5 days...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27980538/gene-mutations-responsible-for-primary-immunodeficiency-disorders-a-report-from-the-first-primary-immunodeficiency-biobank-in-iran
#7
Saba Sheikhbahaei, Roya Sherkat, Dirk Roos, Majid Yaran, Somayeh Najafi, Alireza Emami
BACKGROUND: Primary immunodeficiency (PID) is a heterogeneous group of inheritable genetic disorders with increased susceptibility to infections, autoimmunity, uncontrolled inflammation and malignancy. Timely precise diagnosis of these patients is very essential since they may not be able to live with their congenital immunity defects; otherwise, they could survive with appropriate treatment. DNA biobanks of such patients could be used for molecular and genetic testing, facilitating the detection of underlying mutations in known genes as well as the discovery of novel genes and pathways...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27956908/analysis-of-feline-and-canine-allergen-components-in-patients-sensitized-to-pets
#8
Natalia Ukleja-Sokołowska, Ewa Gawrońska-Ukleja, Magdalena Żbikowska-Gotz, Ewa Socha, Kinga Lis, Łukasz Sokołowski, Andrzej Kuźmiński, Zbigniew Bartuzi
BACKGROUND: Component resolved allergen diagnosis allows for a precise evaluation of the sensitization profiles of patients sensitized to felines and canines. An accurate interpretation of these results allows better insight into the evolution of a given patients sensitizations, and allows for a more precise evaluation of their prognoses. METHODS: 70 patients (42 women and 28 men, aged 18-65, with the average of 35.5) with a positive feline or canine allergy diagnosis were included in the research group...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27956907/lymphocyte-kv1-3-channels-in-the-pathogenesis-of-chronic-obstructive-pulmonary-disease-novel-therapeutic-implications-of-targeting-the-channels-by-commonly-used-drugs
#9
REVIEW
Itsuro Kazama, Tsutomu Tamada
In patients with chronic obstructive pulmonary disease (COPD), over-activated T-lymphocytes produce pro-inflammatory cytokines and proliferate in situ in the lower airways and pulmonary parenchyma, contributing substantially to the pathogenesis of the disease. Despite our understanding of the molecular mechanisms by which lymphocytes are activated, we know little about the physiological mechanisms. T-lymphocytes predominantly express delayed rectifier K(+)-channels (Kv1.3) in their plasma membranes and these channels play crucial roles in inducing the lymphocyte activation and proliferation...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27956906/prevalence-of-beta-lactam-allergy-a-retrospective-chart-review-of-drug-allergy-assessment-in-a-predominantly-pediatric-population
#10
Elissa M Abrams, Andrew Wakeman, Tom V Gerstner, Richard J Warrington, Alexander G Singer
BACKGROUND: Research suggests that 90% of patients labeled beta-lactam allergic are able to tolerate penicillins following further assessment. This study aims to define and describe the frequency of true beta-lactam allergy following allergy patient evaluation in a predominantly pediatric population. METHODS: 306 primary care patients referred between January 2010 and June 2015 were assessed for a suspected beta-lactam allergy. Patient demographics, history and test results were extracted from electronic medical records...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27891156/usefulness-of-component-resolved-analysis-of-cat-allergy-in-routine-clinical-practice
#11
Katharina Eder, Sven Becker, Marion San Nicoló, Alexander Berghaus, Moritz Gröger
BACKGROUND: Cat allergy is of great importance, and its prevalence is increasing worldwide. Cat allergens and house dust mite allergens represent the major indoor allergens; however, they are ubiquitous. Cat sensitization and allergy are known risk factors for rhinitis, bronchial hyperreactivity and asthma. Thus, the diagnosis of sensitization to cats is important for any allergist. METHODS: 70 patients with positive skin prick tests for cats were retrospectively compared regarding their skin prick test results, as well as their specific immunoglobulin E antibody profiles with regard to their responses to the native cat extract, rFel d 1, nFel d 2 and rFel d 4...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27822230/erratum-to-two-weeks-sustained-unresponsiveness-by-oral-immunotherapy-using-microwave-heated-cow-s-milk-for-children-with-cow-s-milk-allergy
#12
Masaya Takahashi, Shoichiro Taniuchi, Kazuhiko Soejima, Yasuko Hatano, Sohsaku Yamanouchi, Kazuanri Kaneko
[This corrects the article DOI: 10.1186/s13223-016-0150-0.].
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27799959/predictors-of-allergen-sensitization-in-singapore-children-from-birth-to-3%C3%A2-years
#13
Evelyn Xiu Ling Loo, Jordan Zheng Ting Sim, Anne Goh, Oon Hoe Teoh, Yiong Huak Chan, Seang Mei Saw, Kenneth Kwek, Peter D Gluckman, Keith M Godfrey, Hugo Van Bever, Yap Seng Chong, Bee Wah Lee, Michael S Kramer, Lynette Pei-Chi Shek
BACKGROUND: Immune responses in allergic diseases begin with allergen sensitization, which usually occurs in childhood. Allergen sensitization involves a complex interplay of genetic and environmental factors, and sensitization patterns may change with age. OBJECTIVE: To determine the predictors of allergen sensitization in the first 3 years of life in the growing up in Singapore towards healthy outcomes (GUSTO) prospective birth cohort study. METHODS: Interviewers collected information on demographics, family history of allergy, social and lifestyle factors, and the child's health...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27799958/th17-responses-are-not-altered-by-natural-exposure-to-seasonal-allergens-in-pollen-sensitive-patients
#14
Agata Schramm, Barbara Jasiewicz-Honkisz, Grzegorz Osmenda, Grzegorz Wilk, Mateusz Siedlinski, Agnieszka Sagan, Pawel T Matusik, Joanna Maciag, Tomasz Sliwa, Marta Czesnikiewicz-Guzik, Tomasz P Mikolajczyk
BACKGROUND: Allergic rhinitis affects 10-30 % of the global population and this number is likely to increase in the forthcoming years. Moreover, it commonly co-exists with allergic asthma as a chronic allergic respiratory syndrome. While the involvement of Th2 cells in allergy is well understood, alterations of pro-inflammatory Th17 responses remain poorly characterized. The aim of our study was to determine whether natural seasonal allergen exposure causes changes in T cell subset characteristics in patients with allergic rhinitis and asthma...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27799957/prospective-evaluation-of-testing-with-baked-milk-to-predict-safe-ingestion-of-baked-milk-in-unheated-milk-allergic-children
#15
Allison Kwan, Maria Asper, Sasson Lavi, Elana Lavine, David Hummel, Julia E Upton
BACKGROUND: Cow's milk allergy is one of the most common food allergies affecting young children. A subset of milk-allergic individuals can eat baked milk without allergic symptoms which is beneficial in terms of prognostication and liberalization of the diet. A retrospective study suggested that skin prick testing (SPT) with a baked milk (muffin) slurry may provide a sensitive means of predicting the outcome of a medically supervised baked milk oral food challenge. We evaluated the predictive value of SPT with baked milk to identify unheated milk-allergic children who are able to safely eat baked milk...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27777594/clinical-validation-of-controlled-exposure-to-birch-pollen-in-the-environmental-exposure-unit-eeu
#16
Anne K Ellis, Mena Soliman, Lisa M Steacy, Daniel E Adams, Barnaby Hobsbawn, Terry J B Walker
BACKGROUND: The Environmental Exposure Unit (EEU) in Kingston, Ontario, Canada is a controlled allergen challenge facility (CACF) that has been previously clinically validated for the use of ragweed and grass pollen in clinical studies. In this study we aim to validate the use of birch pollen to challenge allergic participants. METHODS: A total of 59 volunteers were screened and 38 birch allergic participants and ten non-allergics completed the study, outside of tree pollen season...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27777593/genetic-and-epigenetic-studies-of-atopic-dermatitis
#17
REVIEW
Lianghua Bin, Donald Y M Leung
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory disease caused by the complex interaction of genetic, immune and environmental factors. There have many recent discoveries involving the genetic and epigenetic studies of AD. METHODS: A retrospective PubMed search was carried out from June 2009 to June 2016 using the terms "atopic dermatitis", "association", "eczema", "gene", "polymorphism", "mutation", "variant", "genome wide association study", "microarray" "gene profiling", "RNA sequencing", "epigenetics" and "microRNA"...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27777592/air-pollution-epigenetics-and-asthma
#18
REVIEW
Hong Ji, Jocelyn M Biagini Myers, Eric B Brandt, Cole Brokamp, Patrick H Ryan, Gurjit K Khurana Hershey
Exposure to traffic-related air pollution (TRAP) has been implicated in asthma development, persistence, and exacerbation. This exposure is highly significant as large segments of the global population resides in zones that are most impacted by TRAP and schools are often located in high TRAP exposure areas. Recent findings shed new light on the epigenetic mechanisms by which exposure to traffic pollution may contribute to the development and persistence of asthma. In order to delineate TRAP induced effects on the epigenome, utilization of newly available innovative methods to assess and quantify traffic pollution will be needed to accurately quantify exposure...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27777591/interacting-effects-of-obesity-race-ethnicity-and-sex-on-the-incidence-and-control-of-adult-onset-asthma
#19
Corinna Koebnick, Heidi Fischer, Matthew F Daley, Assiamira Ferrara, Michael A Horberg, Beth Waitzfelder, Deborah Rohm Young, Michael K Gould
BACKGROUND: To improve care and control for patients with adult-onset asthma, a better understanding of determinants of their risk and outcomes is important. We investigated how associations between asthma, asthma control and obesity may be modified by patient demographic characteristics. METHODS: This retrospective study of adults enrolled in several health plans across the U.S. (n = 2,860,305) examined the interacting effects of obesity, age, race, and sex on adult-onset asthma and asthma control...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27766109/adrenal-suppression-in-children-treated-with-swallowed-fluticasone-and-oral-viscous-budesonide-for-eosinophilic-esophagitis
#20
Alexandra Ahmet, Eric I Benchimol, Ellen B Goldbloom, Janice L Barkey
BACKGROUND: Adrenal suppression (AS), a glucocorticoid (GC) side effect associated with significant morbidity, is well described related to inhaled corticosteroid therapy for asthma. Swallowed topical glucocorticoid therapy is the main pharmacotherapy treatment for eosinophilic esophagitis (EoE) and therefore children with EoE are potentially at increased risk of AS. METHODS: In this prospective cohort study, we included children and youth <18 years diagnosed with EoE and treated with swallowed fluticasone or oral viscous budesonide for more than 1 month...
2016: Allergy, Asthma, and Clinical Immunology
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