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Allergy, Asthma, and Clinical Immunology

Farhad Seif, Babak Ghalehbaghi, Hossein Aazami, Alireza Mohebbi, Aslan Ahmadi, Reza Falak, Pegah Babaheidarian, Mohammad Najafi, Majid Khoshmirsafa, Sahand Ghalehbaghi, Mehdi Shekarabi
Background: Chronic Rhinosinusitis (CRS) is a persistent inflammatory disease affecting paranasal sinuses. CRS is categorized into two distinct subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Although several immune cells are involved in the CRS pathogenesis, the role of T cells is not fully understood. The objective of the present study was to evaluate the frequency of CD4+ and CD8+ T cells and macrophages in the sinonasal mucosa of CRS patients, as well as to investigate the specific transcription factors for Th1, Th2, Th17, and Treg cells...
2018: Allergy, Asthma, and Clinical Immunology
Hye Jung Park, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Chin Kook Rhee, Kyungjoo Kim, Bo Yeon Kim, Hye Won Bae, Kwang-Ha Yoo
Background: Asthma requires regular follow-up visits and sustained medication use. Although several studies have reported the importance of adherence to medication and compliance with the treatment, none to date have reported the importance of regular follow-up visits. We investigated the effects of regular clinical visits on asthma exacerbation. Methods: We used claims data in the national medical insurance review system provided by the Health Insurance Review and Assessment Service of Korea...
2018: Allergy, Asthma, and Clinical Immunology
Jian Li, Bin Wang, Yingying Luo, Yajie Bian, Ruipei Wang
Background: Allergic rhinitis (AR), characterized by sneezing, nasal itching and rhinorrhea, affects a large number of population. This study aimed to explore the effects of artemisinin alone or combined with neurectomy of pterygoid canal in ovalbumin-induced AR mouse model and illustrate the underlying mechanisms. Methods: Allergic symptoms were evaluated to verify inhibitory effect of artemisinin alone or combined with neurectomy of pterygoid canal on AR. Serum levels of histamine, immunoglobulin E (IgE) and inflammatory factors TNF, INF-γ, IL-1β IL-10, IL-4 and IL-5 were measured by ELISA...
2018: Allergy, Asthma, and Clinical Immunology
Kyunguk Jeong, Jung-Dong Lee, Dae Ryong Kang, Sooyoung Lee
Background: Previous reports on anaphylaxis in Asia are limited to relatively small-scale studies. We performed this study to identify the nationwide prevalence of anaphylaxis and epinephrine prescription rates by age groups. Methods: The total number of patients, yearly and overall prevalence, percentage of emergency department visits, and epinephrine prescription rates were calculated for patients diagnosed with anaphylaxis based on the Korean National Health Insurance database from 2010 to 2014...
2018: Allergy, Asthma, and Clinical Immunology
Francesco Menzella, Mirco Lusuardi, Carla Galeone, Gloria Montanari, Alberto Cavazza, Nicola Facciolongo
Background: Bronchial thermoplasty (BT) is an endoscopic procedure for the treatment of severe refractory asthma, based on the local airways delivery of radio-frequency at 65 °C. Several controlled clinical studies demonstrated the effectiveness of BT on clinical outcomes, particularly the reduction of asthma exacerbations. During procedure or shortly after, significant but transient respiratory adverse events have been reported. Case report: We describe the case of a male, caucasian, 56-year-old, non-smoker patient with non-allergic severe asthma...
2018: Allergy, Asthma, and Clinical Immunology
Victoria Alejandra Gonzales-González, Adolfo Martin Díaz, Karla Fernández, María Félix Rivera
Background: Food allergy is a public health problem that has increased in the last decade. Despite the increasing rates in children, quality data on the burden of these diseases is lacking particularly in developing countries. Honduras has no studies in pediatric patients. Objectives: The objective of this research was to identify the most common sensitization patterns to food through epicutaneous skin testing and food allergy rates in children and their correlation with common allergic diseases in a group of patients from Hospital of Pediatrics Maria...
2018: Allergy, Asthma, and Clinical Immunology
Arturo J Bonnin, Charles DeBrosse, Terri Moncrief, G Wendell Richmond
Background: Angioedema secondary to acquired C1 inhibitor deficiency (AAE) is a rare disease. It usually is associated with lymphoproliferative disorders. We present a case of AAE in a patient with antiphospholipid syndrome (APS), a non-Hodgkin lymphoproliferative disorder (NHL) with undetectable levels of C2, C4, and an undetectable CH50. The co-existence of AAE, APS, and NHL, with an undetectable C2 level, to the best of our knowledge, has never before reported together in the same patient...
2018: Allergy, Asthma, and Clinical Immunology
Hongyu Wang, Melanie Kjarsgaard, Terence Ho, John D Brannan, Parameswaran Nair
Background: Sputum induction with hypertonic saline in obstructive airway diseases is generally safe. However, saline induces bronchoconstriction in some patients despite pre-medication with Salbutamol. Our objectives were to investigate the predictors of failure of Salbutamol to protect against saline-induced-bronchoconstriction in patients with asthma and COPD and to evaluate implications for asthma therapy. Methods: Retrospective survey on a database of 3565 patients with obstructive airway diseases who had sputum induced with hypertonic saline...
2018: Allergy, Asthma, and Clinical Immunology
Bilal Alaskhar Alhamwe, Razi Khalaila, Johanna Wolf, Verena von Bülow, Hani Harb, Fahd Alhamdan, Charles S Hii, Susan L Prescott, Antonio Ferrante, Harald Renz, Holger Garn, Daniel P Potaczek
This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the development of allergic diseases, including the immune mechanisms underlying this development. Together with DNA methylation, histone modifications (including histone acetylation, methylation, phosphorylation, ubiquitination, etc.) represent the classical epigenetic mechanisms. However, much less attention has been given to histone modifications than to DNA methylation in the context of allergy...
2018: Allergy, Asthma, and Clinical Immunology
Jie Gao, Feng Wu
Background: The fractional exhaled nitric oxide (FeNO) and blood eosinophils are biomarkers of eosinophilic airway inflammation used in the diagnosis and management of asthma, although induced sputum is the gold standard test for phenotypic asthma. Nevertheless, the clinical application of the correlation between sputum eosinophils, FeNO and blood eosinophils is controversial. Objective: To investigate the clinical application of the correlation between sputum eosinophils, FeNO and blood eosinophils with uncontrolled asthmatic patients...
2018: Allergy, Asthma, and Clinical Immunology
Agnieszka Skrzypulec-Frankel, Katarzyna Bieniek, Alicja Kasperska-Zając
No abstract text is available yet for this article.
2018: Allergy, Asthma, and Clinical Immunology
Kara Robertson, Stephen Couban, Desmond Leddin, Imran Ahmad, Lori Connors
Background: Chronic granulomatous disease (CGD) is a rare primary immunodeficiency characterized by recurrent life-threatening bacterial and fungal infections, granuloma formation and intestinal disease. This disease is caused by defects in NADPH oxidase, which result in the inability of phagocytes (neutrophils, monocytes and macrophages) to destroy certain microbes. The only established curative therapy for CGD is hematopoietic stem cell transplantation. Case presentation: A 23-year-old Caucasian male with X-linked chronic granulomatous disease underwent a reduced-intensity conditioning, matched unrelated donor peripheral blood stem cell transplant, after which he was started on tacrolimus and mycophenolate for graft-versus-host disease prophylaxis...
2018: Allergy, Asthma, and Clinical Immunology
Majid Emtiazy, Laleh Oveidzadeh, Minoo Habibi, Leila Molaeipour, Daryush Talei, Zahra Jafari, Mahmoud Parvin, Mohammad Kamalinejad
Background: Asthma is one of the important chronic diseases. The asthma prevalence is increasing in last decades. Despite the presence of good controller drugs like corticosteroids, about 60% of asthmatic patients use alternative medicine. This study was done to determine the effectiveness of Tregonella foenum graceum (fenugreek) seeds in mild asthma. Methods: It is a double blind trial with placebo effect. One of the ancient prescriptions from Persian Medicine was selected...
2018: Allergy, Asthma, and Clinical Immunology
Don Husereau, Jason Goodfield, Richard Leigh, Richard Borrelli, Michel Cloutier, Alain Gendron
Background: Stratification of patients with severe asthma by blood eosinophil counts predicts responders to anti-interleukin (IL)-5 (mepolizumab and reslizumab) and anti-IL-5 receptor α (benralizumab) therapies. This study characterized patients with severe asthma who could qualify for these biologics in a primary care setting. Methods: We retrospectively selected patients from July 1, 2010, to June 30, 2014, using a linked electronic medical records (EMR) database (IMS Evidence 360 EMR Canada) for > 950,000 patients in primary care in Ontario, Canada...
2018: Allergy, Asthma, and Clinical Immunology
A Grosso, F Locatelli, E Gini, F Albicini, C Tirelli, I Cerveri, A G Corsico
Background: Over the years it has been widely stated that approximately one-third of asthmatic women experience worsening of the disease during pregnancy. However, the literature has not been reviewed systematically and the meta-analytic reviews include old studies. This study aimed to examine whether the prevalence of worsening asthma during pregnancy is still consistent with prior estimate or it has been reduced. Methods: A detailed Clinical Questionnaire on respiratory symptoms, medical history, medication, use of services, occupation, social status, home environment and lifestyle was administered to random samples of the Italian population in the frame of the Gene Environment Interactions in Respiratory Diseases (GEIRD) study...
2018: Allergy, Asthma, and Clinical Immunology
B Bonnet, K Messaoudi, F Jacomet, E Michaud, J L Fauquert, D Caillaud, B Evrard
Background: Cats are the major source of indoor inhalant allergens after house dust mites. The global incidence of cat allergies is rising sharply, posing a major public health problem. Ten cat allergens have been identified. The major allergen responsible for symptoms is Fel d 1, a secretoglobin and not a lipocalin, making the cat a special case among mammals. Main body: Given its clinical predominance, it is essential to have a good knowledge of this allergenic fraction, including its basic structure, to understand the new exciting diagnostic and therapeutic applications currently in development...
2018: Allergy, Asthma, and Clinical Immunology
Luciana Kase Tanno, Ana Luiza Bierrenbach, F Estelle R Simons, Victoria Cardona, Bernard Yu-Hor Thong, Nicolas Molinari, Moises A Calderon, Margitta Worm, Yoon-Seok Chang, Nikolaos G Papadopoulos, Thomas Casale, Pascal Demoly
In contrast to the majority of allergic or hypersensitivity conditions, worldwide anaphylaxis epidemiological data remain sparse with low accuracy, which hampers comparable morbidity statistics. Data can differ widely depending on a number of variables. In the current document we reviewed the forms on which anaphylaxis has been defined and classified; and how it can affect epidemiological data. With regards to the methods used to capture morbidity statistics, we observed the impact of the anaphylaxis coding utilizing the World Health Organization's International Classification of Diseases...
2018: Allergy, Asthma, and Clinical Immunology
Yukihiko Kato, Yu Sato, Miho Nakasu, Ryoji Tsuboi
Background: We experienced a rare case of immediate type hypersensitivity and late phase reaction to anti-tubercular therapy consisting of ethambutol and levofloxacin, which occurred in close succession, giving the appearance of a single, continuous reaction to one drug. Case presentation: The patient was a man in his 70's who began therapy consisting of isoniazide, rifampicin, and ethambutol for pulmonary tuberculosis. Since the patient had a drug eruption within several hours after the start of his treatment, his reaction to ethambutol was assessed first among the three suspected drugs using an oral challenge test...
2018: Allergy, Asthma, and Clinical Immunology
Devarajan Rathish, Sisira Siribaddana
Background: Tuberculosis induced autoimmune haemolytic anaemia is a rare entity. The aim of this study was to explore its common presentations, investigation findings and treatment options through a systematic review of published reports. Methods: PubMed, Trip, Google Scholar, Science Direct, Cochrane Library, Open-Grey, Grey literature report and the reference lists of the selected articles were searched for case reports in English on tuberculosis induced auto-immune haemolytic anaemia...
2018: Allergy, Asthma, and Clinical Immunology
Richard Bwanika, Charles D Kato, Johnson Welishe, Daniel C Mwandah
Background: Malaria and helminths share the same geographical distribution in tropical Africa. Studies of the interaction of helminth and malaria co-infection in humans have been few and are mainly epidemiological, with little information on cellular immune responses. This study aimed to determine Cytokine profiles among patients co-infected with Plasmodium falciparum malaria and soil borne helminth attending Kampala International University Teaching Hospital (KIU). Methods: A case control study of 240 patients were recruited at KIU teaching hospital...
2018: Allergy, Asthma, and Clinical Immunology
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