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Allergy, Asthma, and Clinical Immunology

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https://www.readbyqxmd.com/read/30214459/a-multi-stakeholder-perspective-on-asthma-care-in-canada-findings-from-a-mixed-methods-needs-assessment-in-the-treatment-and-management-of-asthma-in-adults
#1
Suzanne Murray, Sara Labbé, Alan Kaplan, Kristine Petrasko, Susan Waserman
Background: Although several aspects of asthma care have been identified as being sub-optimal in Canada, such as patient education, practice guideline adoption, and access to care, there remains a need to determine the extent to which these gaps remain, so as to investigate their underlying causes, and potential solutions. Methods: An ethics-approved mixed methods educational needs assessment was conducted in four Canadian provinces (Alberta, British Columbia, Ontario, and Quebec), combining a qualitative phase (45-min semi-structured interviews with community-based healthcare providers and key stakeholders) and a quantitative phase (15-min survey, healthcare providers only)...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/30186335/common-allergies-in-urban-adolescents-and-their-relationships-with-asthma-control-and-healthcare-utilization
#2
Hyekyun Rhee, Tanzy Love, Donald Harrington, Annette Grape
Background: Urban adolescents suffer a disproportionate burden of asthma morbidity, often in association with allergies. Literature is limited on comparing various types of allergies regarding prevalence and associations with asthma morbidity in urban dwelling adolescents. The purpose of this study was to examine the prevalence of common allergies reported by urban adolescents and to assess their relationships to healthcare utilization and asthma control. Methods: Study participants included 313 urban adolescents (12-20 years of age) with persistent asthma who were recruited from three states in the United States...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/30154874/effects-of-nasal-dilator-strips-on-subjective-measures-of-sleep-in-subjects-with-chronic-nocturnal-nasal-congestion-a-randomized-placebo-controlled-trial
#3
Eric J Schenkel, Renee Ciesla, Gilbert Marava Shanga
Background: This exploratory study investigated effects of a new asymmetric butterfly-shaped prototype nasal dilator strip and the currently marketed clear Breathe Right Nasal Strip (BRNS) on subjective measures of nasal congestion and sleep quality. Methods: In this randomized, double-blind study, subjects with chronic nasal congestion and sleep difficulties were assigned a BRNS clear strip, an asymmetric butterfly prototype, or an asymmetric butterfly placebo strip without springs, to use nightly for 2 weeks...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/30151016/unintentional-injection-to-the-bone-with-a-pediatric-epinephrine-auto-injector
#4
Mariam Ibrahim, Harold Kim
Background: Skin-to-bone distance (STBD) in children prescribed a pediatric epinephrine auto-injector (EAI) for anaphylaxis is not commonly measured in practice. Recent evidence suggests that children with STBD less than the exposed needle length of available pediatric EAIs (dose: 0.15 mg, needle length: 12.7 mm) are at risk for unintentional injections to the bone during their use for an allergic emergency. Case presentation: Described here is a case of a female child with multiple food allergies prescribed a pediatric EAI (0...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/30127805/real-world-outcomes-in-hereditary-angioedema-first-experience-from-the-icatibant-outcome-survey-in-the-united-kingdom
#5
Hilary J Longhurst, John Dempster, Lorena Lorenzo, Matthew Buckland, Sofia Grigoriadou, Christine Symons, Claire Bethune, Vincent Fabien, Catherine Bangs, Tomaz Garcez
Background: Hereditary angioedema (HAE) is a potentially life-threatening, bradykinin-mediated disease, often misdiagnosed and under-treated, with long diagnostic delays. There are limited real-world data on best-practice management of HAE in the UK. Objectives: To characterize the clinical profile, management and outcomes of patients with HAE type I and II from three specialist centres in the UK using data from the Icatibant Outcome Survey (IOS; Shire, Zug, Switzerland), an international observational study monitoring safety and effectiveness of icatibant, a selective bradykinin B2 receptor antagonist...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/30123298/timing-of-infections-in-patients-with-primary-immunodeficiencies-treated-with-intravenous-immunoglobulin-ivig
#6
Parwinder K Gill, Stephen D Betschel
Purpose: Patients with common variable immune deficiency and X-linked agammaglobulinemia are unable to produce their own antibodies thus leading to a higher incidence of recurrent infections, particularly those involving the sinuses and lungs. Treatment with intravenous immunoglobulin therapy aims to reduce the incidence of infections; however, as serum IgG approaches its trough during the third and fourth week after infusion, we hypothesized that the rate of infection would be higher during this time period...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/30065761/serum-periostin-levels-following-small-bone-fractures-long-bone-fractures-and-joint-replacements-an-observational-study
#7
Rachel Varughese, Ruth Semprini, Claire Munro, James Fingleton, Cecile Holweg, Mark Weatherall, Richard Beasley, Irene Braithwaite
Background: In asthma, serum periostin may potentially be used as a biomarker in the management of patients with Type-2 eosinophilic airway inflammation. However, serum periostin may be influenced by factors other than Type 2 inflammation, potentially confounding its interpretation. We aimed to measure change in periostin following bone injury. Methods: 102 adults without asthma were recruited into three groups: joint replacement surgery, long bone fracture, short bone fracture...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/30026764/interplay-between-acute-phase-response-and-coagulation-fibrinolysis-in-chronic-spontaneous-urticaria
#8
R Grzanka, A Damasiewicz-Bodzek, A Kasperska-Zajac
Background: Chronic spontaneous urticaria (CSU) is associated with activation of systemic inflammatory response and coagulation/fibrinolysis. Aim: To study whether there is a relationship between the acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria (CSU) patients. Methods: Serum concentrations of C-reactive protein (CRP) and interleukin 6 (IL-6), key markers of acute phase response and of D-dimer, a marker of fibrin turnover were investigated in 58 CSU patients assessed with the urticaria activity score (UAS) and the controls...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/30002685/frequency-of-cd4-and-cd8-t-cells-in-iranian-chronic-rhinosinusitis-patients
#9
Farhad Seif, Babak Ghalehbaghi, Hossein Aazami, Alireza Mohebbi, Aslan Ahmadi, Reza Falak, Pegah Babaheidarian, Mohammad Najafi, Majid Khoshmirsafa, Sahand Ghalehbaghi, Mehdi Shekarabi
Background: Chronic Rhinosinusitis (CRS) is a persistent inflammatory disease affecting paranasal sinuses. CRS is categorized into two distinct subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Although several immune cells are involved in the CRS pathogenesis, the role of T cells is not fully understood. The objective of the present study was to evaluate the frequency of CD4+ and CD8+ T cells and macrophages in the sinonasal mucosa of CRS patients, as well as to investigate the specific transcription factors for Th1, Th2, Th17, and Treg cells...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/30002684/regular-follow-up-visits-reduce-the-risk-for-asthma-exacerbation-requiring-admission-in-korean-adults-with-asthma
#10
Hye Jung Park, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Chin Kook Rhee, Kyungjoo Kim, Bo Yeon Kim, Hye Won Bae, Kwang-Ha Yoo
Background: Asthma requires regular follow-up visits and sustained medication use. Although several studies have reported the importance of adherence to medication and compliance with the treatment, none to date have reported the importance of regular follow-up visits. We investigated the effects of regular clinical visits on asthma exacerbation. Methods: We used claims data in the national medical insurance review system provided by the Health Insurance Review and Assessment Service of Korea...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29991950/effect-of-artemisinin-and-neurectomy-of-pterygoid-canal-in-ovalbumin-induced-allergic-rhinitis-mouse-model
#11
Jian Li, Bin Wang, Yingying Luo, Yajie Bian, Ruipei Wang
Background: Allergic rhinitis (AR), characterized by sneezing, nasal itching and rhinorrhea, affects a large number of population. This study aimed to explore the effects of artemisinin alone or combined with neurectomy of pterygoid canal in ovalbumin-induced AR mouse model and illustrate the underlying mechanisms. Methods: Allergic symptoms were evaluated to verify inhibitory effect of artemisinin alone or combined with neurectomy of pterygoid canal on AR. Serum levels of histamine, immunoglobulin E (IgE) and inflammatory factors TNF, INF-γ, IL-1β IL-10, IL-4 and IL-5 were measured by ELISA...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29988631/a-population-based-epidemiological-study-of-anaphylaxis-using-national-big-data-in-korea-trends-in-age-specific-prevalence-and-epinephrine-use-in-2010-2014
#12
Kyunguk Jeong, Jung-Dong Lee, Dae Ryong Kang, Sooyoung Lee
Background: Previous reports on anaphylaxis in Asia are limited to relatively small-scale studies. We performed this study to identify the nationwide prevalence of anaphylaxis and epinephrine prescription rates by age groups. Methods: The total number of patients, yearly and overall prevalence, percentage of emergency department visits, and epinephrine prescription rates were calculated for patients diagnosed with anaphylaxis based on the Korean National Health Insurance database from 2010 to 2014...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29983718/heat-induced-necrosis-after-bronchial-thermoplasty-a-new-concern
#13
Francesco Menzella, Mirco Lusuardi, Carla Galeone, Gloria Montanari, Alberto Cavazza, Nicola Facciolongo
Background: Bronchial thermoplasty (BT) is an endoscopic procedure for the treatment of severe refractory asthma, based on the local airways delivery of radio-frequency at 65 °C. Several controlled clinical studies demonstrated the effectiveness of BT on clinical outcomes, particularly the reduction of asthma exacerbations. During procedure or shortly after, significant but transient respiratory adverse events have been reported. Case report: We describe the case of a male, caucasian, 56-year-old, non-smoker patient with non-allergic severe asthma...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29946340/prevalence-of-food-allergens-sensitization-and-food-allergies-in-a-group-of-allergic-honduran-children
#14
Victoria Alejandra Gonzales-González, Adolfo Martin Díaz, Karla Fernández, María Félix Rivera
Background: Food allergy is a public health problem that has increased in the last decade. Despite the increasing rates in children, quality data on the burden of these diseases is lacking particularly in developing countries. Honduras has no studies in pediatric patients. Objectives: The objective of this research was to identify the most common sensitization patterns to food through epicutaneous skin testing and food allergy rates in children and their correlation with common allergic diseases in a group of patients from Hospital of Pediatrics Maria...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29881401/case-report-presenting-the-diagnostic-challenges-in-a-patient-with-recurrent-acquired-angioedema-antiphospholipid-antibodies-and-undetectable-c2-levels
#15
Arturo J Bonnin, Charles DeBrosse, Terri Moncrief, G Wendell Richmond
Background: Angioedema secondary to acquired C1 inhibitor deficiency (AAE) is a rare disease. It usually is associated with lymphoproliferative disorders. We present a case of AAE in a patient with antiphospholipid syndrome (APS), a non-Hodgkin lymphoproliferative disorder (NHL) with undetectable levels of C2, C4, and an undetectable CH50. The co-existence of AAE, APS, and NHL, with an undetectable C2 level, to the best of our knowledge, has never before reported together in the same patient...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29853927/loss-of-bronchoprotection-to-salbutamol-during-sputum-induction-with-hypertonic-saline-implications-for-asthma-therapy
#16
Hongyu Wang, Melanie Kjarsgaard, Terence Ho, John D Brannan, Parameswaran Nair
Background: Sputum induction with hypertonic saline in obstructive airway diseases is generally safe. However, saline induces bronchoconstriction in some patients despite pre-medication with Salbutamol. Our objectives were to investigate the predictors of failure of Salbutamol to protect against saline-induced-bronchoconstriction in patients with asthma and COPD and to evaluate implications for asthma therapy. Methods: Retrospective survey on a database of 3565 patients with obstructive airway diseases who had sputum induced with hypertonic saline...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29796022/histone-modifications-and-their-role-in-epigenetics-of-atopy-and-allergic-diseases
#17
REVIEW
Bilal Alaskhar Alhamwe, Razi Khalaila, Johanna Wolf, Verena von Bülow, Hani Harb, Fahd Alhamdan, Charles S Hii, Susan L Prescott, Antonio Ferrante, Harald Renz, Holger Garn, Daniel P Potaczek
This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the development of allergic diseases, including the immune mechanisms underlying this development. Together with DNA methylation, histone modifications (including histone acetylation, methylation, phosphorylation, ubiquitination, etc.) represent the classical epigenetic mechanisms. However, much less attention has been given to histone modifications than to DNA methylation in the context of allergy...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29796021/association-between-fractional-exhaled-nitric-oxide-sputum-induction-and-peripheral-blood-eosinophil-in-uncontrolled-asthma
#18
Jie Gao, Feng Wu
Background: The fractional exhaled nitric oxide (FeNO) and blood eosinophils are biomarkers of eosinophilic airway inflammation used in the diagnosis and management of asthma, although induced sputum is the gold standard test for phenotypic asthma. Nevertheless, the clinical application of the correlation between sputum eosinophils, FeNO and blood eosinophils is controversial. Objective: To investigate the clinical application of the correlation between sputum eosinophils, FeNO and blood eosinophils with uncontrolled asthmatic patients...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29785187/the-association-between-sexual-dysfunctions-and-severity-of-symptoms-in-patients-with-chronic-spontaneous-urticaria
#19
Agnieszka Skrzypulec-Frankel, Katarzyna Bieniek, Alicja Kasperska-Zając
No abstract text is available yet for this article.
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29755533/new-onset-colitis-in-an-adult-patient-with-chronic-granulomatous-disease-treated-with-hematopoietic-stem-cell-transplantation-a-diagnostic-dilemma
#20
Kara Robertson, Stephen Couban, Desmond Leddin, Imran Ahmad, Lori Connors
Background: Chronic granulomatous disease (CGD) is a rare primary immunodeficiency characterized by recurrent life-threatening bacterial and fungal infections, granuloma formation and intestinal disease. This disease is caused by defects in NADPH oxidase, which result in the inability of phagocytes (neutrophils, monocytes and macrophages) to destroy certain microbes. The only established curative therapy for CGD is hematopoietic stem cell transplantation. Case presentation: A 23-year-old Caucasian male with X-linked chronic granulomatous disease underwent a reduced-intensity conditioning, matched unrelated donor peripheral blood stem cell transplant, after which he was started on tacrolimus and mycophenolate for graft-versus-host disease prophylaxis...
2018: Allergy, Asthma, and Clinical Immunology
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