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International Heart Journal

Su Nam Lee, Ki-Dong Yoo, Min Seop Jo
In massive pulmonary thromboembolism, requiring cardiopulmonary resuscitation, venous-arterial extracorporeal membrane oxygenation can decompress the overloaded right atrium and ventricle while stabilizing hemodynamic status. However, vascular injuries occur in slightly less than 20% of cases during cannulation. In a 44-year-old woman with suspected pulmonary thromboembolism, a common femoral artery perforation occurred unexpectedly during cannulation for extracorporeal membrane oxygenation. The patient was unstable due to active bleeding...
November 5, 2018: International Heart Journal
Qing-Ping Tian, Mei-Lin Liu, Chao-Shu Tang, Lin Xue, Yong-Zheng Pang, Yong-Fen Qi
Neuregulin-4 (Nrg4) is a newly discovered adipokine that is synthesized in many tissues and plays an important role in modulating systemic energy metabolism and in the development of metabolic disorders. However, little is known about the relationship between Nrg4 and coronary artery disease (CAD). In this study, we investigated the association between Nrg4 and the presence and severity of CAD.We enrolled 73 patients diagnosed by coronary angiography (CAG) as having CAD and 32 controls. The CAD group was divided into two subgroups according to their SYNTAX score...
November 5, 2018: International Heart Journal
Qiyong Li, Minghui Pang, Minjia Zhu, Li Chen
C-type natriuretic peptide (CNP) hyperpolarizes and relaxes the smooth muscle of blood vessels. We investigated whether G-protein-gated inwardly-rectifying K+ channels (GIRK) and large-conductance calcium-activated K+ channels (BKCa channels) were involved in CNP-evoked vasodilatation in human arteries. Isometric tension in human gastroepiploic arteries was measured using a wire myograph. Ion channel currents were recorded by the whole-cell patch-clamp technique. The concentration-dependent vasodilation induced by CNP was reduced significantly after inhibition of GIRK channels (by tertiapin-Q) or of BKCa channel (by paxilline)...
November 5, 2018: International Heart Journal
Masato Okada, Kazunori Kashiwase, Akio Hirata, Yasuharu Takeda, Ryohei Amiya, Yasunori Ueda, Yoshiharu Higuchi, Yoshio Yasumura
Right ventricular apical (RVA) pacing often causes left ventricular (LV) mechanical asynchrony, which is enhanced by impaired cardiac contraction and intrinsic conduction abnormality. However, data on patients with normal cardiac function and under RV non-apical (non-RVA) pacing are limited.We retrospectively investigated 97 consecutive patients with normal ejection fraction who received pacemaker implantation for atrioventricular block with the ventricular lead placed in a non-RVA position. We defined mechanical asynchrony as discoordinate contraction between opposing regions of the LV wall evaluated by echocardiography...
November 5, 2018: International Heart Journal
Shota Tsuchida, Takashi Matsuzaki, Masaki Yamato, Keiji Okuda, Hai Ying Fu, Ryo Araki, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Hiroyuki Hao, Seiji Takashima, Masafumi Kitakaze, Yasushi Sakata, Eisuke Mekada, Tetsuo Minamino
For atherosclerotic cardiovascular diseases (ACD), gene therapy may be a potential therapeutic strategy; however, lack of effective and safe methods for gene delivery to atherosclerotic plaques have limited its potential therapeutic applications. To overcome this limitation, we developed a novel antibody-based gene delivery system (anti-HB-EGF/NA vector) by chemically crosslinking antibodies against human heparin-binding epidermal growth factor-like growth factor (HB-EGF). It has been shown to be excessively expressed in human atherosclerotic plaques and NeutrAvidin (NA) for conjugating biotinylated siRNA...
November 5, 2018: International Heart Journal
Takeya Suzuki, Tadashi Fujino, Masaya Shinohara, Hideki Koike, Toshio Kinoshita, Hitomi Yuzawa, Takanori Ikeda
The SelectSecure™ lead system (SSLS), which is composed of a thin lumenless, active-fixation lead and a deflectable catheter, is approved for use in Japan. This study aimed to evaluate the long-term clinical outcomes of right ventricular (RV) septal pacing with the SSLS along with the system's safety and electrical performance. A total of 129 patients were divided into the following 3 groups: the RV septal pacing with the SSLS group (SSP, n = 21); the RV septal pacing with the conventional lead group (Septal, n = 77); and the RV apical pacing with the conventional lead group (Apical, n = 31)...
November 5, 2018: International Heart Journal
Yue Chen, Shouling Wu, Wenyu Li, Binhao Wang, Haichen Lv, Xiaolei Yang, Bin Waleed Khalid, Xiaomeng Yin, Yunlong Xia
In this study, we aim to investigate the association of serum uric acid (SUA) with the prevalence of premature ventricular contraction (PVC). The relationship between SUA and the prevalence of PVC in 98,965 subjects (79,034 male subjects, mean age: 51.9 ± 12.6 years old) in the Kailuan cohort study (n = 101,510, age range: 18-98 years) from June 2006 to October 2007 was investigated. These subjects were divided into five groups on the basis of their SUA levels. A multivariate logistic regression model was constructed to evaluate the association between SUA and the prevalence of PVC...
November 5, 2018: International Heart Journal
Koichiro Kinugawa, Naoki Sato, Takayuki Inomata
The present meta-analysis aimed to evaluate effects of tolvaptan on fluid retention in patients with heart failure who were non-responsive to conventional treatment and to assess differences between effects of low (≤ 15 mg/day) and high (> 15 mg/day) tolvaptan doses.Randomized controlled trials comparing add-on tolvaptan therapy and placebo or therapy with other diuretics in patients with heart failure were identified through a database search. The primary outcomes were changes in body weight and urine volume, and the secondary outcomes were changes in serum sodium and creatinine levels...
October 25, 2018: International Heart Journal
Kun Li, Jing Yang, Wenjia Guo, Tingting Lv, Jihong Guo, Jianfeng Li, Ping Zhang
Long QT syndrome is a rare but potentially lethal cardiac channelopathy. The primary aim of the study was to investigate the long-term effects of video-assisted thoracoscopic (VATS) left cardiac sympathetic denervation (LCSD) in Chinese patients with long QT syndrome.VATS-LCSD was performed in eight Chinese patients with LQTS. Twelve-lead ECGs and 24-hour Holter monitoring ECGs were recorded before and after surgery. The medical charts were reviewed to obtain patient data, and the patients who had been lost to follow-up were contacted through telephone...
October 25, 2018: International Heart Journal
Keisuke Kojima, Shigeki Kimura, Kazuto Hayasaka, Masafumi Mizusawa, Toru Misawa, Yosuke Yamakami, Yuichiro Sagawa, Hirofumi Ohtani, Keiichi Hishikari, Tomoyo Sugiyama, Hiroyuki Hikita, Atsushi Takahashi
Non-obstructive angioscopy has become a novel method of evaluating atheromatous plaques of the aortic intimal wall. A 77-year-old man with coronary artery disease underwent percutaneous coronary intervention in the left descending artery. We subsequently used non-obstructive angioscopy to identify aortic atheromatous plaques and incidentally diagnosed an aortic dissecting aneurysm. Non-obstructive angioscopy demonstrated a great fissure in severe atheromatous plaques at the entry site of the aortic dissection identified by enhanced computed tomography...
October 25, 2018: International Heart Journal
Ryohei Fujimoto, Taku Asano, Hideyuki Maezawa, Hisa Shimojima, Miki Tsujiuchi, Yoshiro Hori, Mio Ebato, Hiroshi Suzuki
A 52-year-old woman with intermittent complete atrioventricular (AV) block detected on exercise was admitted to the hospital. Echocardiography revealed lesions on the right ventricular side of the interventricular septum and free wall of the basal inferolateral area. Gadolinium-enhanced cardiovascular magnetic resonance (CMR) imaging revealed the mass and wall thickening at the same locations with late gadolinium enhancement (LGE). Focal uptake at the septal lesion was detected using 67Ga scintigraphy. Focal on diffuse intense uptake in the lesions was observed on Fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) imaging...
October 25, 2018: International Heart Journal
Kennosuke Yamashita, Myong Hwa Yamamoto, Wataru Igawa, Morio Ono, Takehiko Kido, Seitarou Ebara, Toshitaka Okabe, Shigeo Saito, Kisaki Amemiya, Naoei Isomura, Hiroshi Araki, Masahiko Ochiai
The relationship between epicardial adipose tissue volume (EATV) and plaque vulnerability in non-culprit coronary lesions is not clearly understood.Fifty-four consecutive patients/158 lesions with suspected coronary artery disease underwent computed tomography (CT) and 40 MHz intravascular ultrasound imaging (iMap-IVUS) in cardiac catheterization. Cross-sectional CT slices were semiautomatically traced from base to apex of the heart. Using a 3D workstation, EATV was measured as the sum of fat areas (-190 to -30 Hounsfield units [HU])...
October 25, 2018: International Heart Journal
Kenzo Ichimura, Tetsuya Matoba, Jun-Ichiro Koga, Kaku Nakano, Daiki Funamoto, Hiroyuki Tsutsui, Kensuke Egashira
Statins are known to improve pulmonary arterial hypertension (PAH) by their anti-inflammatory and anti-proliferative effects in animal models. However, recent clinical studies have reported that clinically approved statin doses failed to improve clinical outcomes in patients with PAH. We therefore hypothesized that nanoparticle (NP)-mediated targeting of pitavastatin could attenuate the progression of established PAH.We induced PAH by subcutaneously injecting monocrotaline (MCT) in Sprague-Dawley rats. On day 14 after the MCT injection, animals that displayed established PAH on echocardiography were included...
October 25, 2018: International Heart Journal
Hai-Ping Tian, Yan-Hong Sun, Lan He, Ya-Fang Yi, Xiang Gao, Ding-Li Xu
Angiotensin II (Ang II), an effective component of renin-angiotensin system, plays a pivotal role in cardiac fibrosis, which may further contribute to heart failure. Single-stranded DNA-binding protein 1 (SSBP1), a DNA damage response protein, regulates both mitochondrial function and extracellular matrix remodeling. In this study, we aim to investigate the role of SSBP1 in cardiac fibrosis that is induced by Ang II. We infused C57BL/6J mice with vehicle or Ang II and valsartan using implanted osmotic mini-pumps...
October 25, 2018: International Heart Journal
Yasuo Okumura, Katsuaki Yokoyama, Naoya Matsumoto, Eizo Tachibana, Keiichiro Kuronuma, Koji Oiwa, Michiaki Matsumoto, Toshiaki Kojima, Ken Arima, Tomobumi Kotani, Kazumiki Nomoto, Yukitoshi Ikeya, Seiji Fukushima, Motoyuki Onikura, Yasuko Suzuki, Masami Fujita, Hideyuki Ando, Norikazu Ishikawa, Atsushi Hirayama
The burden of anticoagulation treatment affects patient satisfaction, which in turn affects adherence to treatment. Thus, we must thoroughly understand the advantages of direct oral anticoagulants (DOACs) over vitamin K antagonists (VKAs)/warfarin given for stroke prevention in patients with atrial fibrillation (AF). We compared satisfaction with anticoagulation therapy between 654 DOAC and 821 warfarin users enrolled in the SAKURA AF Registry. Satisfaction was assessed by means of the Anti-Clot Treatment Scale (ACTS), which includes 12-item burdens and 3-item benefits scales, and the treatment satisfaction questionnaire for medication II (TSQM II), which includes 2-item effectiveness, 3-item side effects, 3-item convenience, and 2-item global satisfaction domains...
October 25, 2018: International Heart Journal
Takayuki Warisawa, Takanobu Mitarai, Shunichi Doi, Mizuho Kasahara, Norio Suzuki, Manabu Takai, Hisao Matsuda, Yoshihiro J Akashi
We report a case of successful percutaneous retrieval of an unexpectedly disrupted balloon catheter using GuideLiner and a low-profile balloon. The procedure and the mechanism of this novel technique were described in detail with ex-vivo testing. This case demonstrated the utility of the combination of GuideLiner and low-profile balloon as a bail-out for intravascular foreign body.
October 25, 2018: International Heart Journal
Yugo Nara, Yusuke Watanabe, Akihisa Kataoka, Makoto Nakashima, Hirofumi Hioki, Fukuko Nagura, Hideyuki Kawashima, Kumiko Konno, Hiroyuki Kyono, Naoyuki Yokoyama, Ken Kozuma
Our aim was to assess the clinical effects of myocardial injury after transcatheter aortic-valve implantation (TAVI). Between October 2013 and July 2016, 157 patients underwent TAVI with Sapien XT, Sapien 3, or CoreValve prostheses at our institute. Of these, 130 patients for whom the transapical approach was not used were included in this study. Myocardial injury was defined as a peak troponin I level of ≥1.5 ng/mL within 48 hours after TAVI. We evaluated the predictors of myocardial injury and compared the clinical outcomes of 82 patients classified as the myocardial injury group and 44 patients classified as the non-myocardial injury group...
October 25, 2018: International Heart Journal
Jin-Tao Wu, Xian-Wei Fan, Hai-Tao Yang, Li-Jie Yan, Xian-Jing Xu, Shan-Ling Wang, Ying-Jie Chu, De-Yong Long, Jian-Zeng Dong
Interatrial block (IAB) is associated with a multitude of medical conditions. The aim of this retrospective study was to investigate whether CHADS2 (congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, prior stroke) score is positively associated with the development of IAB. A total of 1072 patients (men, 555; women, 517; mean age, 61 ± 14 years) were included in the study. P-wave duration was measured manually using a caliper. IAB was defined as a P-wave duration of ≥ 120 ms on a 12-lead electrocardiogram...
October 25, 2018: International Heart Journal
Kaoru Yamashita, Atsushi Kohjitani, Masaaki Miyata, Sachi Ohno, Akina Tohya, Mitsuru Ohishi, Mitsutaka Sugimura
Myocardial ischemic events after non-cardiac surgery is still a serious problem, especially in older, high-risk patients. However, the prevalence and risk factors of blood pressure (BP) abnormalities, which may possibly lead to myocardial ischemic attack, have not been reported. Our aim is to elucidate predictive factors of postoperative BP abnormalities following a minor-to-moderate surgery, employing preoperative left ventricular diastolic function. Patients who underwent cardiac echocardiogram examination and received oral and maxillofacial surgery under general anesthesia were enrolled...
October 25, 2018: International Heart Journal
Ying Guo, Changpeng Song, Xi Wu, Xinxin Zheng, Jie Lu, Xiaonan Fang, Shuiyun Wang, Xiaohong Huang
There is limited information on long-term outcomes of mitral valve repair for mitral regurgitation (MR) caused by different degrees of myxomatous degeneration. The aim of this study was to compare the surgical results of patients with advanced and mild/moderate myxomatous mitral valve degeneration (MVD). We identified 130 patients (25 advanced and 105 mild/moderate MVD patients) who underwent mitral valve repair for MR and were pathologically diagnosed as myxomatous degeneration. Follow-up was 100% complete (mean length, 5...
October 25, 2018: International Heart Journal
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