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International Heart Journal

Yumika Tsuji, Masahiro Koide, Kanade Katsura, Hiroshi Fujita, Hatsue Ishibashi-Ueda, Fumiyuki Otsuka
A 53-year-old male presented with acute myocardial infarction and was subsequently implanted with a 4.0 × 28 mm everolimus-eluting platinum chromium stent in his proximal left anterior descending artery. Eight months after the implantation, he developed exertional angina and underwent coronary angiography, which revealed significant in-stent restenosis (ISR). Percutaneous coronary intervention was performed 1 month later, and the pre-procedural optical coherence tomography (OCT) revealed a diffusely bordered and rapidly attenuated signal-poor region with invisible stent struts at ISR site, potentially indicating a "lipid-laden" neointima...
July 15, 2018: International Heart Journal
Toshiyuki Yano, Motohisa Yamamoto, Atsushi Mochizuki, Toshifumi Ogawa, Nobutaka Nagano, Takefumi Fujito, Junichi Nishida, Daigo Nagahara, Koki Abe, Takayuki Miki, Chisako Suzuki, Hiroki Takahashi, Hatsue Ishibashi-Ueda, Tetsuji Miura
IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder characterized by lymphoplasmacytic infiltration of numerous IgG4-positive plasma cells, leading to fibrous thickening in the affected tissue. Typical cardiovascular manifestations of IgG4-RD are periaortitis, coronary arteritis, and pericarditis. Rare cases of myocardial involvement in IgG4-RD have been reported, but surgical resection or open biopsy was required for the diagnosis in those cases. Here, we report a case in which percutaneous transcatheter biopsy under the guidance of intracardiac echocardiography was useful for diagnosis of IgG4-RD manifested as an intracavitary right atrial mass, extending into the superior vena cava...
July 15, 2018: International Heart Journal
Tetsuo Yamaguchi, Takamichi Miyamoto, Masahiro Sekigawa, Keita Watanabe, Sadahiro Hijikata, Junji Yamaguchi, Takamasa Iwai, Yuichiro Sagawa, Ryoichi Miyazaki, Ryo Masuda, Naoyuki Miwa, Nobuhiro Hara, Yasutoshi Nagata, Toru Obayashi, Toshihiro Nozato
Japan is facing problems associated with "heart failure (HF) pandemics" and bed shortages in core hospitals that can accommodate patients with acute HF. The prognosis is currently unknown for acute HF patients who were transferred from core hospitals to collaborating hospitals during the very early treatment phase and whose treatment strategies are in place.We enrolled 166 acute HF patients who were hospitalized between January 1, 2015, and December 31, 2015, and compared the conditions of transferred patients (n = 53, median duration before transfer = 6 days) and nontransferred patients (n = 113)...
July 15, 2018: International Heart Journal
Seigo Okada, Jun Muneuchi, Yusaku Nagatomo, Chie Yokota, Junya Ohmura, Junko Yamamoto, Mamie Watanabe, Chiaki Iida, Hiromitsu Shirouzu, Yasuhiko Takahashi
Hemodynamically significant patent ductus arteriosus (PDA) in preterm infants increases morbidity and mortality. Here we describe a 12-day-old neonate with a huge PDA who developed pulmonary hemorrhage following disseminated intravascular clotting and multiple organ failure. Medical treatment or surgical ligation could not be performed because of the patient's poor condition. Transcatheter closure using a commercially available device (Amplatzer Vascular Plug II) successfully treated the huge PDA without major complications...
July 15, 2018: International Heart Journal
Ruriko Numata, Takafumi Inoue, Akihiro Yoshimoto, Masayuki Fujisaki, Sei Morizumi, Yoshihiro Suematsu
Thoracoscopic left atrial appendectomy is a minimally invasive procedure for left atrial appendage occlusion in patients with non-valvular atrial fibrillation, particularly those at a great risk for both stroke and bleeding despite appropriate oral anticoagulant therapy. It serves as an alternative strategy for stroke risk reduction. Moreover, the oral anticoagulant therapy can be discontinued after the operation. However, we encountered a 74-year old male patient who developed cardiogenic stroke after thoracoscopic left atrial appendectomy...
June 22, 2018: International Heart Journal
Yan Chen, Wing-Kuk Au, Daniel Chan, Ko-Yung Sit, Zhe Zhen, Kar-Lai Ho, Debbie Wong, Lai-Ming Ho, Desmond Yap, Yui-Ming Lam, Chu-Pak Lau, Hung-Fat Tse, Tak-Mao Chan, Kai-Hang Yiu
Concomitant chronic kidney disease (CKD) is common in patients with significant valvular heart disease (VHD). This study sought to evaluate the clinical benefit of valvular surgery in patients with concomitant CKD.We evaluated 349 patients with significant VHD who were referred for surgery. Patients were divided into those with CKD stage ≥ 3 (CKD patients; n = 88) and those with CKD stage 1 or 2 (no CKD patients; n = 261). 63 patients did not receive surgery, of which 20 patients had CKD and 43 had no CKD...
June 20, 2018: International Heart Journal
Younan Yao, Jian Zhang, Yuhui Zhang, Rongcheng Zhang
The aim of this study was to investigate the effect on mortality of torsemide and a combination of loop diuretics (furosemide + torsemide) in contemporary practice in patients with chronic heart failure (HF).We investigated patients with HF in the Heart Failure Center of Fuwai Hospital from 2009 to 2013 who were discharged on furosemide, torsemide, or a combination of the 2 drugs. Using inverse probability weighting (IPW) to account for nonrandom selection of diuretic strategies, we assessed the association between different diuretic strategies and mortality...
June 6, 2018: International Heart Journal
Hong-Jie Yang, Xin Liu, Chuan Qu, Shao-Bo Shi, Jin-Jun Liang, Bo Yang
Red cell distribution width (RDW) has been associated with heart failure (HF) hospitalization in the general population, but the correlation to HF hospitalization in patients with hypertrophic cardiomyopathy (HCM) is unclear.Ninety-eight HCM patients without a history of HF were enrolled and RDW was assessed as a predictor.During a 16.8 ± 9.0 month follow-up period, 17 subjects were hospitalized due to HF. HF hospitalization patients had higher RDW than non-HF patients (14.7 ± 1.4% versus 13.0 ± 0.9%, P < 0...
June 6, 2018: International Heart Journal
Norio Aoyama, Jun-Ichi Suzuki, Naho Kobayashi, Tomoya Hanatani, Norihiko Ashigaki, Asuka Yoshida, Yuka Shiheido, Hiroki Sato, Yuichi Izumi, Mitsuaki Isobe
The aim of this study was to determine the correlation between periodontopathic bacteria and diabetes mellitus (DM) status in cardiovascular disease (CVD) subjects.DM is associated with the progression of periodontitis. Several epidemiological studies have suggested that periodontitis may be a risk factor for CVD. However, no study has compared the periodontal condition between well-controlled and poorly-controlled DM patients with CVD.The subjects were well-controlled (n = 73) or poorly-controlled (n = 39) DM patients with CVD...
June 6, 2018: International Heart Journal
Yoshihiro Kimura, Masahiro Yamada, Kenji Hanada, Tomohide Endo, Noritomo Narita, Masato Narita, Maiko Senoo, Manabu Yonekura, Hiroaki Ichikawa, Shizuka Kurauchi, Shigeyuki Nakaji, Ken Okumura, Hirofumi Tomita
We previously showed that J-waves were found more frequently in patients with low levels of serum eicosapentaenoic acid (EPA) in the acute phase of myocardial infarction, and were associated with the incidence of ischemia-related ventricular arrhythmias. However, the relationship between J-waves and serum EPA levels in a general population remains to be elucidated.The Iwaki Health Promotion Project is an ongoing community-based health promotion study in Iwaki, Hirosaki, which is in northern Japan. A total of 1,052 residents (mean age, 53...
June 6, 2018: International Heart Journal
Shimpei Ito, Akihiro Endo, Taiji Okada, Hiroyuki Yoshitomi, Ryoji Hyakudomi, Yoshitsugu Tajima, Kazuaki Tanabe
A 55-year-old man was presented to the emergency room because of abdominal pain for 4 days. He had a history of atopic dermatitis. Left ventricular (LV) asynergy and thrombus was detected on echocardiography, and superior mesenteric vein thrombosis was detected by computed tomography. There are no reported cases of this combination of thrombi. We hypothesized that the reason for this complication is the combination of coagulation disorder due to atopic dermatitis, silent myocardial infarction, and exacerbation of the coagulation abnormality due to bacteremia, leading to superior mesenteric vein and LV thrombosis...
June 6, 2018: International Heart Journal
Sinisa Stojkovic, Stefan Juricic, Milan Dobric, Milan A Nedeljkovic, Vladan Vukcevic, Dejan Orlic, Goran Stankovic, Miloje Tomasevic, Srdjan Aleksandric, Miodrag Dikic, Milorad Tesic, Zlatko Mehmedbegovic, Nikola Boskovic, Milorad Zivkovic, Vladimir Dedovic, Dejan Milasinovic, Miodrag Ostojic, Branko Beleslin
The objective of the study was to evaluate major adverse cardiovascular events (MACE) after successful versus failed percutaneous coronary intervention for chronic total occlusion (PCI-CTO).Limited data are available on long-term clinical follow-up in the treatment of chronic total occlusion (CTO).Between January 2009 and December 2010 PCI-CTO was attempted in 283 consecutive patients with 289 CTO lesions. Procedural success was 62.3% and clinical follow-up covered 83% (235/283) of the study population with a median follow-up of 66 months (range, 59-74)...
June 6, 2018: International Heart Journal
Tomoko Himi, Akira Koike, Osamu Nagayama, Yuko Kato, Isao Nishi, Akira Sato, Takeshi Yamashita, Kazutaka Aonuma
Cardiac patients often experience nocturnal and daytime oscillatory breathing (OB). OB noted at rest sometimes becomes unclear or even disappears during exercise. We evaluated the physiological significance of OB by comparing the clinical characteristics of cardiac patients who manifested OB only at rest (group A), only during exercise (group B), and both at rest and during exercise (group C).Among 3,432 cardiac patients who underwent cardiopulmonary exercise testing (CPX), 114, 94, and 65 patients were identified as group A, B, and C, respectively...
June 6, 2018: International Heart Journal
Yuji Okura, Sumika Ishigaki, Satoko Sakakibara, Chika Yumoto, Mitsue Hashitate, Chika Sekine, Tomomi Fujita, Tsugumi Takayama, Kazuyuki Ozaki, Nobuaki Sato, Tohru Minamino
Aortic stenosis (AS) is a life-threatening comorbidity of cancer patients. Aortic valve replacement (AVR) should be considered for some cancer patients, but neither the characteristics nor prognosis under conservative therapy is well known.We searched our echocardiography log (years 2005-2014) for cancer patients with AS, and 92 patients (54% female) were included in the study. To compare the survival curves, 470 control patients without AS were selected from our cancer registry.Mean age (± SD) was 77.6 ± 6...
June 6, 2018: International Heart Journal
Kana Kubota, Katsura Soma, Masae Uehara, Toshiro Inaba, Akihito Saito, Norihiko Takeda, Masaru Hatano, Hiroyuki Morita, Ryo Inuzuka, Yasutaka Hirata, Atsushi Yao, Issei Komuro
Candida prosthetic endocarditis (CPE) is an uncommon and fatal complication in adults with congenital heart disease. The current guidelines for the management of fungal endocarditis recommend a combination of surgical and medical therapy. However, it still remains uncertain when surgical management in CPE patients should be performed. Therefore, the prognosis of CPE patients is very poor. Here we report a case of CPE in a 31-year-old woman who had undergone surgical repair for tetralogy of Fallot during childhood and pulmonary valve replacement at the age of 21 years...
June 6, 2018: International Heart Journal
Aijun Liu, Yiping Sun, Bo Yu
MicroRNAs, a class of small and non-encoding RNAs that transcriptionally or post-transcriptionally modulate the expression of their target genes, have been implicated as critical regulatory molecules in ischemia-/reperfusion-induced cardiac injury. In the present study, we report on the role of miR-208a in myocardial I/R injury and the underlying cardio-protective mechanism. The gain-of-function and loss-of-function were used to explore the effects of miR-208a on cardiac injury induced by H2 O2 in cardiomyocytes...
June 6, 2018: International Heart Journal
Makoto Murata, Hitoshi Adachi, Shigeru Oshima, Masahiko Kurabayashi
Hyperglycemia is an established risk factor of coronary artery disease (CAD). However, hyperglycemia with preserved pancreatic β cell function induces hyperinsulinemia to correct the glucose profile and may even result in reactive hypoglycemia (RH), which induces an inflammatory response. In this study, the incidence of RH and its effect on arteriosclerosis were examined in CAD patients with a lengthy oral glucose tolerance test (OGTT).We performed a prospective cross-sectional study on 116 nondiabetic CAD patients [70 ± 9 years, 70% male, HbA1c < 6...
June 6, 2018: International Heart Journal
Gaetano Nucifora, Jamie Miller, Carl Gillebert, Ranjit Shah, Rebecca Perry, Cherie Raven, Majo X Joseph, Joseph B Selvanayagam
Aortic valve dysfunction and aortic wall changes are well-known complications of bicuspid aortic valve (BAV) disease. The aim of the present study was to investigate whether a remodeling process of the left ventricle (LV) is present in patients with isolated BAV. Twenty-two consecutive patients (39 ± 15 years, 9 males) with clinically normal BAV and 18 age- and gender-matched control subjects (37 ± 10 years, 9 males) were included. Cardiovascular magnetic resonance (CMR) imaging was performed to evaluate LV function, aortic valve morphology, aortic orifice area, and ascending aorta (AA) dimensions...
June 6, 2018: International Heart Journal
Yoko Ueda, Yuhei Shiga, Yoshiaki Idemoto, Kohei Tashiro, Kota Motozato, Rie Koyoshi, Takashi Kuwano, Kanta Fujimi, Masahiro Ogawa, Keijiro Saku, Shin-Ichiro Miura
The associations between the presence or severity of coronary artery disease (CAD) and measurements of various kinds of fat as assessed by multidetector row computed tomography (MDCT) are unclear. We enrolled 300 patients who were clinically suspected to have CAD or who had at least one cardiac risk factor and had undergone MDCT. The number of significantly stenosed coronary vessels (VD), and measurements of pericardial fat index, paracardial fat index, epicardial fat index, visceral fat index, and subcutaneous fat index were quantified using MDCT...
June 6, 2018: International Heart Journal
Lei Xu, Gang Zhao, Jingfeng Wang, Cheng Shen, Xiao Li, Fei Lu, Hongfa Jiang, George Liu, Kai Hu, Yanhua Tang, Aijun Sun, Junbo Ge
The aim of this study is to investigate the impact of aldehyde dehydrogenase 2 (ALDH2) genotype and alcohol consumption on coronary artery lesions in Chinese patients with stable coronary artery disease (CAD). A total of 753 Chinese patients (73.6% male) diagnosed with stable CAD by coronary angiography were included in the sample. The frequency of the mutated type ALDH2* 2 (including ALDH2* 1/* 2 and ALDH2* 2/* 2) was 44.1% in CAD patients. The mutated ALDH2 carriers were more susceptible to multivessel lesions...
June 6, 2018: International Heart Journal
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