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International Heart Journal

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https://www.readbyqxmd.com/read/28250353/when-a-burr-can-not-penetrate-the-calcified-lesion-increasing-burr-size-as-well-as-decreasing-burr-size-can-be-a-solution-in-rotational-atherectomy
#1
Kenichi Sakakura, Yousuke Taniguchi, Kei Yamamoto, Hiroshi Wada, Shin-Ichi Momomura, Hideo Fujita
In rotational atherectomy (RA), several burr sizes are available, such as 1.25 mm, 1.5 mm, 1.75 mm, or ≥ 2.0 mm. It is important to select an appropriate burr size for each lesion because rotational atherectomy has several unique complications regarding burrs such as entrapment or perforation. When a burr cannot penetrate the lesion, downsizing of the burr is generally recommended. Also, if the smallest burr (1.25 mm) cannot penetrate the lesion, a change to a more supportive or larger French guiding catheter has been recommended...
March 2, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28216549/role-of-right-ventricular-dysfunction-and-diabetes-mellitus-in-n-terminal-pro-b-type-natriuretic-peptide-response-of-patients-with-severe-mitral-regurgitation-and-heart-failure-after-mitraclip
#2
Hidehiro Kaneko, Michael Neuss, Jens Weissenborn, Christian Butter
MitraClip (MC) is an alternative therapeutic option for patients with severe mitral regurgitation (MR) who are at high surgical risk. Most candidates for MC have severe heart failure (HF) with increased N-terminal pro-B-type natriuretic peptide (NT-pro BNP) levels. We sought to clarify the response of NT-pro BNP after MC and to identify the determinants of NT-pro BNP nonresponders. Among 136 consecutive patients successfully treated with MC, we excluded 20 patients due to low baseline NT-pro BNP levels and therefore examined 116 patients...
February 20, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28190794/a-randomized-comparative-study-on-the-efficacy-of-intracoronary-infusion-of-autologous-bone-marrow-mononuclear-cells-and-mesenchymal-stem-cells-in-patients-with-dilated-cardiomyopathy
#3
Wentao Xiao, Suping Guo, Chuanyu Gao, Guoyou Dai, Yongjv Gao, Muwei Li, Xianpei Wang, Dayi Hu
Stem cell therapy has shown therapeutic benefit in dilated cardiomyopathy (DCM), but doubt remains about the most appropriate stem cell subpopulation. The current study compared the efficacy of intracoronary administration of bone marrow mononuclear cells (BMMC) or mesenchymal stem cells (BMSC) in patients with DCM.Fifty-three patients with DCM and reduced (< 40%) left ventricular ejection fraction (LVEF), were randomized to intracoronary infusion of BMMC (BMMC group, n = 16) or BMSC (BMSC group, n = 17) or equal volume normal saline (CTRL group, n = 20)...
February 13, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28077821/ascending-aortic-constriction-promotes-cardiomyocyte-proliferation-in-neonatal-rats
#4
Zhenhua Wang, Sebastian Schmull, Hui Zheng, Jianggui Shan, Rongjiang Zou, Song Xue
Adult heart suffering from increased workload will undergo myocardial hypertrophy, subsequent cardiomyocyte (CM) death, and eventually heart failure. However, the effect of increasing afterload on the neonatal heart remains unknown. We performed ascending aortic constriction (AAC) in neonatal rats 8-12 hours after birth (P0, P indicates postpartum). Seven days after surgery, in vivo heart function was evaluated using cardiac ultrasonography. Haematoxylineosin and Masson staining were used to assess CM diameter and collagen deposition...
January 11, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28123164/congenital-corrected-transposition-of-great-arteries-tga
#5
Yasushi Imai
No abstract text is available yet for this article.
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28123163/overview-of-current-evidence-on-the-impact-of-the-initial-high-dose-of-the-direct-factor-xa-inhibitor-rivaroxaban-on-thrombus-resolution-in-the-treatment-of-venous-thromboembolism
#6
Rupert Bauersachs, Norimichi Koitabashi
Incomplete thrombus resolution in patients with venous thromboembolism (VTE) may increase the risk of recurrent thromboembolic events and other complications, such as post-thrombotic syndrome. Various options exist for thrombus resolution, including systemic thrombolytic agents, catheter-directed thrombolysis, and traditional anticoagulants such as heparins or vitamin K antagonists (VKAs). Data are accumulating on the use of non-VKA oral anticoagulants, such as rivaroxaban, and these may provide greater thrombus resolution compared with VKAs...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28123162/cardiac-sarcoidosis-diagnosed-by-incidental-lymph-node-biopsy
#7
Jun Matsuda, Katsuhito Fujiu, Solji Roh, Miyu Tajima, Hisataka Maki, Toshiya Kojima, Tetsuo Ushiku, Kan Nawata, Norihiko Takeda, Masafumi Watanabe, Hiroshi Akazawa, Issei Komuro
Cardiac involvement in systemic sarcoidosis sometimes provokes life-threatening ventricular tachyarrhythmia. Steroid administration is one of the fundamental anti-arrhythmia therapies. For an indication of steroid therapy, a definitive diagnosis of sarcoidosis is required.(1)) However, cases that are clearly suspected of cardiac sarcoidosis based on their clinical courses sometimes do not meet the current diagnostic criteria and result in the loss of an appropriate opportunity to perform steroid therapy.Here we report a case that was diagnosed as sarcoidosis by incidental biopsy of an inguinal lymph node during cardiac resuscitation for cardiac tamponade...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28123161/estimated-prevalence-of-heterozygous-familial-hypercholesterolemia-in-patients-with-acute-coronary-syndrome
#8
Hirotoshi Ohmura, Yoshifumi Fukushima, Atsushi Mizuno, Koichiro Niwa, Yohei Kobayashi, Toshiaki Ebina, Kazuo Kimura, Shun Ishibashi, Hiroyuki Daida
Heterozygous familial hypercholesterolemia (FH) represents a strong risk for development of premature coronary artery disease (CAD). However, the majority of patients with FH are undiagnosed and the prevalence likely represents an underestimate in most countries. In Japan, the possible contribution of FH to the development of CAD may be higher because of the low incidence of CAD among the general population. We estimated the prevalence of heterozygous FH by measuring Achilles tendon thickness (ATT) in patients with acute coronary syndrome (ACS)...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28123160/effects-of-statins-and-xuezhikang-on-the-expression-of-secretory-phospholipase-a2-group-iia-in-rat-vascular-smooth-muscle-cells
#9
Qiang Xie, Dan Zhang
Atherosclerosis is a multifactorial vascular disease characterized by formation of inflammatory lesions. Secretory phospholipase A2, group IIA (sPLA2-IIA) is involved in this process and plays a critical role. However, the exact role of sPLA2-IIA in cardiovascular inflammation is more complicated and remains unclear. Furthermore, both statins and Xuezhikang (XZK) are widely used in the prevention and treatment of cardiovascular disease risk because of their pleiotropic effects on the cardiovascular system. However, their effects on sPLA2-IIA are still controversial...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28111413/acute-coronary-syndrome-with-or-without-heterozygous-familial-hypercholesterolemia
#10
Shin-Ichiro Miura
No abstract text is available yet for this article.
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28111412/prostaglandin-e2-signaling-as-a-target-of-anti-cardiac-fibrosis-in-heart-failure-treatment
#11
Mutsuo Harada, Norifumi Takeda, Haruhiro Toko
No abstract text is available yet for this article.
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28111411/serial-observations-of-in-stent-restenosis-treated-with-drug-coated-balloon-angioplasty-by-optical-coherence-tomography-and-coronary-angioscopy
#12
Nobuhiro Murata, Tadateru Takayama, Takafumi Hiro
The drug-coated balloon (DCB) is a device that is used to reduce the risk of stent re-implantation in patients with in-stent restenosis (ISR). However, imaging findings of the drug covering the neointimal plaque immediately after treatment of ISR by DCB, and during follow-up, have only been discussed in a few reports. Herein, we describe the use of optical coherence tomography (OCT) and angioscopy to evaluate ISR before and after treatment with DCB, and during the follow-up period in 3 patients. The patients developed critical ISR during the follow-up period after drug-eluting stent (DES) implantation...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28111410/who-needs-longer-tolvaptan-treatment
#13
Koichiro Kinugawa, Takayuki Inomata, Naoki Sato, Moriyoshi Yasuda, Toshiyuki Shimakawa, Kosuke Bando, Yasuhiko Fukuta
The vasopressin receptor 2 (V2) receptor antagonist tolvaptan is an aquaretic agent that has been approved for heart failure patients with volume overload in Japan. In this study (SMILE study), we investigated patient characteristics and effectiveness in both a 14 days and shorter treated group (14DS) and 15 days and longer treated group (15DL). The results showed that the patients in the 15DL group had low cardiac output with intensive diuretic administration (ie, diuretic resistance). The congestive symptoms were greatly improved within 14 days of treatment in both the 14DS and 15DL groups...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28111409/correct-diagnosis-of-wild-type-transthyretin-related-amyloidosis-followed-by-the-introduction-of-a-novel-therapy-in-a-patient-with-cardiac-wall-thickening-of-unknown-cause
#14
Naoko Sawada, Atsuko Nakayama, Masao Takahashi, Mariko Tanaka, Hiroyuki Morita, Hiroshi Akazawa, Issei Komuro
We report here the case of a 67-year-old man who was initially diagnosed with myocardial hypertrophy with progressive hypertensive heart disease. After 6 years a cardiac biopsy was conducted because of changes in the electrocardiogram and transthoracic echocardiogram results, revealing amyloid deposition. Additional genetic studies revealed no TTR gene mutations, leading to a definitive diagnosis of wild-type transthyretin-related amyloidosis (ATTR). The patient started taking diflunisal as a stabilizer which is one of the advanced therapies for ATTR, and then the heart failure symptoms and brain natriuretic peptide (BNP) level improved in short-term follow-up...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28111408/the-mitochondrial-trna-ala-t5655c-mutation-may-modulate-the-phenotypic-expression-of-trna-met-and-trna-gln-a4401g-mutation-in-a-han-chinese-family-with-essential-hypertension
#15
Yunhong Xu, Ximing Chen, Huanliang Huang, Wanting Liu
Mutations in mitochondrial DNA are associated with the pathogenesis of essential hypertension. We report here the clinical, genetic, and molecular characterization of a three-generation Han Chinese family with essential hypertension. Most strikingly, this family exhibited a high penetrance of essential hypertension. Sequence analysis of the mitochondrial genome showed the presence of a homoplasmic T5655C mutation in tRNA(Ala), together with the A4401G mutation in the adjacent region between tRNA(Met) and tRNA(Gln)...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28111407/determinants-of-aortic-size-and-stiffness-and-the-impact-on-exercise-physiology-in-patients-after-the-fontan-operation
#16
Hideo Ohuchi, Yosuke Hayama, Jun Negishi, Kanae Noritake, Aya Miyazaki, Osamu Yamada, Isao Shiraishi
The pathophysiology of congenital heart disease includes aortic dilation and increased stiffness. However, the clinical determinants and significance remain unclear in patients after the Fontan operation.Size and stiffness index (SI) of the ascending and descending aorta (aAO and dAO, respectively) were assessed using angiography in 130 consecutive Fontan patients and 30 age-matched controls. Compared with controls, Fontan patients showed a dilated aAO and smaller dAO (P < 0.0001) with greater SI (3.2 ± 0...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28100877/transcatheter-aortic-valve-implantation-with-different-valve-designs-for-severe-device-landing-zone-calcification
#17
Yoshio Maeno, Yigal Abramowitz, Yoshio Kazuno, Hiroyuki Kawamori, Geeteshwar Mangat, Nobuyuki Takahashi, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, Hasan Jilaihawi, Raj R Makkar
Severe device landing zone calcification (DLZ-CA) predicted paravalvular leak (PVL) and post-dilatation (PD) after transcatheter aortic valve implantation (TAVI). The aim of this study was to determine the influence of DLZ-CA on PVL or PD rates after SAPIEN XT (XT) versus CoreValve (CV).We analyzed patients undergoing TAVI who had severe DLZ-CA. Severe DLZ-CA defined the upper left ventricular outflow tract calcification; the cross-sectional region 2 mm inferior to the annular plane. PVL was evaluated at 30days using transthoracic echocardiography...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28100876/primary-percutaneous-coronary-intervention-followed-by-valve-surgery-for-acute-coronary-syndrome-at-left-main-trunk-complicated-with-severe-aortic-stenosis
#18
Akira Shikuma, Jun Shiraishi, Kazunari Okawa, Masaki Yashige, Keisuke Shoji, Daisuke Ito, Masayoshi Kimura, Eigo Kishita, Yusuke Nakagawa, Masayuki Hyogo, Akiyuki Takahashi, Takahisa Sawada
An 89-year-old woman appeared to have acute coronary syndrome at the left main trunk (LMT) complicated with severe aortic stenosis, moderate-severe mitral regurgitation, depressed left ventricular (LV) function, and multivessel disease. Because of sustained hypotension even under intra-aortic balloon pumping support during emergency coronary angiograhy, we performed primary percutaneous coronary intervention solely for the LMT lesion using a bare metal stent, leading to recovery from the shock state. On the second hospital day, based on our heart-team consensus, we performed aortic valve replacement and coronary artery bypass grafting surgery, and added edge-to-edge repair (Alfieri stitch) of the mitral valve, resulting in complete revascularization and dramatically improved LV function...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28100875/the-role-of-thiol-disulphide-homeostasis-in-anthracycline-associated-cardiac-toxicity
#19
Mustafa Topuz, Omer Şen, Mehmet Kaplan, Oguz Akkus, Ozcan Erel, Mustafa Gur
The aim of the present study was to evaluate whether the baseline thiol/disulfide state can predict the occurrence of anthracycline induced cardiac toxicity. A total of 186 cancer patients receiving anthracycline (doxorubicin)-based chemotherapy were enrolled. All patients underwent 2-dimensional (2D) speckle tracking echocardiography (STE) to determine their left ventricular ejection fraction (LVEF) and blood samples for measuring thiol forms were obtained before treatment and 4 weeks after completion of the chemotherapy...
February 7, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28100874/efficacy-of-multidetector-computed-tomography-to-predict-periprocedural-myocardial-injury-after-percutaneous-coronary-intervention-for-chronic-total-occlusion
#20
Eisuke Usui, Tetsumin Lee, Tadashi Murai, Yoshihisa Kanaji, Junji Matsuda, Makoto Araki, Taishi Yonetsu, Yosuke Yamakami, Shigeki Kimura, Tsunekazu Kakuta
Specific signatures of culprit lesions detected on multidetector computed tomography (MDCT) were identified as predictors of periprocedural myocardial injury (PMI) after percutaneous coronary intervention (PCI) in patients with stable angina; PMI has been shown to be associated with a worse prognosis. We investigated the association between preprocedural culprit lesion characteristics, assessed by MDCT, and PMI after PCI for chronic total occlusion (CTO). From three medical centers, 81 patients who underwent pre-PCI MDCT and CTO PCI, and systematic cardiac troponin (cTn) sampling before and after PCI, were included...
February 7, 2017: International Heart Journal
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