journal
MENU ▼
Read by QxMD icon Read
search

International Heart Journal

journal
https://www.readbyqxmd.com/read/30158389/hemoptysis
#1
Sachito Minegishi, Hiroshi Goto, Hideaki Yamabi, Kazuhito Imanaka
Hemoptysis is a rare complication of acute aortic dissection. A 77-year-old woman was admitted to our department with epigastralgia and hemoptysis. Computed tomography showed Stanford A acute aortic dissection and massive posterior mediastinal hematoma which extended along the right pulmonary artery. Hemoptysis is a lethal sign of aortic dissection, therefore, emergency ascending aortic replacement was performed with a good clinical outcome.
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30158388/clinically-worsening-chronic-thromboembolic-pulmonary-hypertension-by-riociguat-after-balloon-pulmonary-angioplasty
#2
Shun Minatsuki, Masaru Hatano, Arihiro Kiyosue, Akihito Saito, Hisataka Maki, Eiki Takimoto, Issei Komuro
Riociguat, a soluble guanylate cyclase stimulator, induces pulmonary artery dilatation through blood flow and is effective in treating chronic thromboembolic pulmonary hypertension (CTEPH). There are two types of vasculopathies in CTEPH based upon its location, in other words, proximal or distal to the thrombus-medicated obstruction. Distal vasculopathy is characterized by intrapulmonary shunts due to diminished blood flow. While other therapeutic interventions for CTEPH including pulmonary endarterectomy and balloon pulmonary angioplasty achieve reperfusion to the distal vasculopathy vessels, the effects of riociguat on distal vasculopathy vessels remain undetermined...
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30158387/endothelial-dysfunction-is-associated-with-cognitive-impairment-of-elderly-cardiovascular-disease-patients
#3
Kazuhiro Fujiyoshi, Minako Yamaoka-Tojo, Yoshiyasu Minami, Toshiki Kutsuna, Shinichi Obara, Ryota Kakizaki, Teruyoshi Nemoto, Takuya Hashimoto, Sayaka Namba, Takao Shimohama, Taiki Tojo, Junya Ako
Cognitive impairment is frequently represented in elderly patients with cardiovascular disease (CVD); yet, the mechanism is uncertain. Recent studies have suggested the association between the vascular endothelial dysfunction and cognitive impairment. The aim of this study was to clarify the association between endothelial dysfunction and cognitive impairment in elderly patients with CVD.A total of 80 elderly patients (> 70 years old) with CVD were included. Patients who had already pharmacologically intervened for cognitive impairment were excluded...
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30158386/prognostic-impact-of-left-atrial-minimal-volume-on-clinical-outcome-in-patients-with-non-obstructive-hypertrophic-cardiomyopathy
#4
Sung-Hee Shin, Ji-Hoon Jang, Yong-Soo Baek, Sung-Woo Kwon, Sang-Don Park, Seong-Ill Woo, Dae-Hyeok Kim, Jun Kwan
Maximal left atrial volume (LAVmax) has been suggested to be an important indicator of left ventricular (LV) diastolic function and a prognosticator in patients with hypertrophic cardiomyopathy (HCM). However, LAVmax can be influenced by LV longitudinal systolic function, which causes systolic descent of the mitral plane. We investigated the prognostic role of LAVmin in patients with HCM and tested if LAVmin is better than LAVmax in predicting clinical outcome in these patients. A total of 167 consecutive patients with HCM were enrolled (age = 64...
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30158385/pre-procedural-thrombolysis-in-myocardial-infarction-flow-in-patients-with-st-segment-elevation-myocardial-infarction
#5
Takuya Hashimoto, Junya Ako, Koichi Nakao, Yukio Ozaki, Kazuo Kimura, Teruo Noguchi, Satoshi Yasuda, Satoru Suwa, Kazuteru Fujimoto, Yasuharu Nakama, Takashi Morita, Wataru Shimizu, Yoshihiko Saito, Atsushi Hirohata, Yasuhiro Morita, Teruo Inoue, Atsunori Okamura, Masaaki Uematsu, Kazuhito Hirata, Kengo Tanabe, Yoshisato Shibata, Mafumi Owa, Kenichi Tsujita, Hiroshi Funayama, Nobuaki Kokubu, Ken Kozuma, Shirou Uemura, Tetsuya Toubaru, Keijirou Saku, Shigeru Oshima, Michikazu Nakai, Kunihiro Nishimura, Yoshihiro Miyamoto, Hisao Ogawa, Masaharu Ishihara
It has been shown that the patency of an infarct-related artery (IRA) before primary percutaneous coronary intervention determines post-procedural success, better preservation of left ventricular function, and lower in-hospital mortality. However, the factors associated with pre-procedural Thrombolysis In Myocardial Infarction (TIMI) flow have not been fully investigated.The Japanese registry of acute Myocardial INfarction diagnosed by Universal dEfiniTion (J-MINUET) is a prospective multicenter registry conducted at 28 Japanese medical institutions between July 2012 and March 2014...
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30158384/safety-tolerability-and-pharmacokinetics-of-nk-104-np
#6
Kaku Nakano, Tetsuya Matoba, Jun-Ichiro Koga, Yushi Kashihara, Masato Fukae, Ichiro Ieiri, Masanari Shiramoto, Shin Irie, Junji Kishimoto, Koji Todaka, Kensuke Egashira
Pulmonary hypertension (PH) is a disease with poor prognosis, caused by the obstruction/stenosis of small pulmonary arteries. Statin is known to have vasodilating and anti-inflammatory property and is considered to be a candidate of therapeutic agents for the treatment of PH, but its efficacy has not been verified in clinical trials. We have formulated pitavastatin incorporating nanoparticles composed of poly (lactic-co-glycolic acid) (NK-104-NP) to improve drug delivery to the pulmonary arteries and evaluated their safety and pharmacokinetics in healthy volunteers...
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30158383/a-useful-scoring-system-for-predicting-right-ventricular-assist-device-requirement-among-patients-with-a-paracorporeal-left-ventricular-assist-device
#7
Daisuke Nitta, Koichiro Kinugawa, Teruhiko Imamura, Eisuke Amiya, Masaru Hatano, Osamu Kinoshita, Kan Nawata, Minoru Ono, Issei Komuro
Ventricular assist devices (VADs) have become an important therapy for advanced heart failure, however, the prognosis of those who receive a biventricular assist device (BiVAD) is still poor. We enrolled 70 patients who underwent paracorporeal VAD (Nipro-VAD® ) implantation between 2004 and 2015 and studied the preoperative risk factors, including hemodynamic parameters for RVAD requirement. Furthermore, 2-year survival was compared between the BiVAD group and LVAD only group. Fourteen patients (20%) required RVAD...
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30158382/aortic-dissection-and-cardiac-dysfunction-emerged-coincidentally-during-the-long-term-treatment-with-angiogenesis-inhibitors-for-metastatic-renal-cell-carcinoma
#8
Midori Takada, Taku Yasui, Toru Oka, Wataru Shioyama, Tadashi Kuroda, Yasutomo Nakai, Kazuo Nishimura, Mikio Mukai, Masashi Fujita
Angiogenesis inhibitors, such as sorafenib and axitinib, which target vascular endothelial growth factor (VEGF) signaling, are widely used for renal cell carcinoma, including metastasis. In this study, we report a case of cardiovascular adverse events of aortic dissection and cardiac dysfunction during treatment with sorafenib and axitinib for metastatic renal cell carcinoma. A 66-year-old man had been administered sorafenib for 2 years after nephrectomy due to renal cell carcinoma. To control the progression of metastatic lung tumor, axitinib was started after sorafenib for four years...
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30158381/peripartum-iliac-arterial-aneurysm-and-rupture-in-a-patient-with-vascular-ehlers-danlos-syndrome-diagnosed-by-next-generation-sequencing
#9
Norimichi Koitabashi, Tomomi Yamaguchi, Daisuke Fukui, Takahide Nakano, Atsushi Umeyama, Kazuyoshi Toda, Ryuichi Funada, Masumi Ishikawa, Rie Kawamura, Kenji Okada, Atsushi Hatamochi, Tomoki Kosho, Masahiko Kurabayashi
Vascular Ehlers-Danlos syndrome (vEDS), a genetic disorder caused by mutations in procollagen type III gene (COL3A1), may lead to fatal vascular complication during peripartum period because of the arterial fragility. We experienced a case of vEDS with peripartum life-threatening arterial rapture diagnosed by next-generation sequencing (NGS) and successfully treated the vascular complications. A 25-year-old female in pregnancy at 34 weeks had sudden and acute pain in the left lower abdomen. After successful delivery, her computed tomography scan showed a dissecting aneurysm of the left common iliac artery (CIA)...
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30158380/implant-characteristics-of-quadripolar-and-bipolar-left-ventricular-leads-for-cardiac-resynchronization-therapy
#10
Kenji Ando, Shigetaka Kanda, Fumiharu Miura, Keiichi Ashikaga, Natsuhiko Ehara, Yoshiaki Sakai, Toshihito Furukawa, Hiroyuki Yoshimura, Kazumasa Adachi
Several studies have reported that the left ventricular (LV) lead implant success rate ranges between 88.0% and 92.4%. Coronary venous anatomy differs among patients thus, necessitating multiple types of leads. To date, the implant success rate among Japanese patients utilizing a pre-specified family LV leads (including bipolar and quadripolar) is not well known. The Attain Success Japan Study enrolled patients indicated for a de novo or an upgrade cardiac resynchronization therapy implant. Patients were followed for 3 months, and the implant success rates with Medtronic Attain family LV leads as well as the incidence of complications related to the LV lead were evaluated...
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30158379/antiremodeling-effect-of-xanthine-oxidase-inhibition-in-a-canine-model-of-atrial-fibrillation
#11
Tomoharu Yoshizawa, Shinichi Niwano, Hiroe Niwano, Hideaki Tamaki, Hironori Nakamura, Tazuru Igarashi, Jun Oikawa, Akira Satoh, Jun Kishihara, Masami Murakami, Hidehira Fukaya, Junya Ako
In a canine rapid atrial stimulation model of atrial fibrillation (AF), we have demonstrated an increased production of reactive oxygen species (ROS) along with electrical and structural remodeling. In the present study, we hypothesized that antioxidants can suppress atrial remodeling canines with AF. We therefore evaluated the effect of febuxostat, a xanthine oxidase (XO) inhibitor and a pure antioxidant, on atrial remodeling.AF was produced by performing a 3-week rapid atrial pacing (400 bpm) in 13 dogs divided into three groups: pacing + febuxostat group (n = 5; atrial pacing with 50 mg/day of febuxostat (administration); pacing control group (n = 5; atrial pacing without any drug administration); and non-pacing group (n = 3)...
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30158378/pre-procedural-n-terminal-pro-b-type-natriuretic-peptide-predicts-contrast-induced-acute-kidney-injury-and-long-term-outcome-in-elderly-patients-after-elective-percutaneous-coronary-intervention
#12
Kai-Yang Lin, Zhi-Yong Wu, Zhe-Bin You, Wei-Ping Zheng, Chun-Jin Lin, Hui Jiang, Jing-Ming Ruan, Yan-Song Guo, Peng-Li Zhu
The aim of the study is to evaluate the association of pre-procedural N-terminal pro-B type natriuretic peptide (NT-proBNP) with contrast-induced acute kidney injury (CI-AKI) and long-term outcomes in elderly patients undergoing elective percutaneous coronary intervention (PCI).A total of 540 patients aged ≥ 75 years who had undergone elective PCI between January 2012 and December 2015 were enrolled in this study. Admission NT-proBNP levels were measured before PCI. CI-AKI was defined as a relative increase in serum creatinine (SCr) of ≥50%, or an absolute increase of ≥ 0...
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30158377/nicotinamide-phosphate-transferase-nampt-increases-in-plasma-in-patients-with-acute-coronary-syndromes-and-promotes-macrophages-to-m2-polarization
#13
Chengxin Zhang, Rui Zhu, Huiping Wang, Qianshan Tao, Xianhe Lin, Shenglin Ge, Zhimin Zhai
Atherosclerosis is an inflammatory disease; monocytes and macrophages play an important role in the progression of this disease. However, the mechanisms are not fully understood yet. Nicotinamide phosphate transferase (NAMPT) is the rate limiting enzyme in the synthesis of NAD, but extracellular NAMPT shows the characteristics of cytokines/adipokines, suggesting that it may be a link between metabolism and inflammation. In this study, we compared the expression levels of the NAMPT/NAD+/Sirt1 signaling pathway as well as NAMPT, CRP and IL-6 in the peripheral blood mononuclear cell (PBMC), and plasma in patients with acute coronary syndromes and healthy subjects, and analyzed their association with macrophage polarization...
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30158376/lncrna-digit-accelerates-tube-formation-of-vascular-endothelial-cells-by-sponging-mir-134
#14
Chaofeng Miao, Haixia Cao, Yonggan Zhang, Xueli Guo, Zifan Wang, Jiaxiang Wang
Atherosclerosis is one of the most prevalent and important cardiac diseases, involving the heart and brain. This study aimed to explore the impacts of lncRNA Divergent to GSC induced by TGF-b family signaling (DIGIT) on vascular endothelial cells tube-formation capacity so as to reveal the potentials of DIGIT in atherosclerosis therapy. DIGIT expression in human microvascular endothelial HMEC-1 cells was silenced by transfection with shRNAs-targeted DIGIT. The effects of DIGIT silence on cell viability, migration, apoptosis, and tube formation were then assessed...
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30158375/imaging-assessment-of-hepatic-changes-after-fontan-surgery
#15
Jinyoung Song, Kyunghee Kim, June Huh, I-Seok Kang, Sung Hoon Kim, Ji-Hyuk Yang, Tae Gook Jun, Ji Hye Kim
The aim of this study was to evaluate hepatic dysfunction over 10 years following Fontan surgery. We assessed the clinical usefulness of diagnostic tools for the detection and follow-up of hepatic dysfunction in patients with Fontan circulation.A total of 26 post-Fontan patients (median age 13 years, range 10-35 years; median duration from Fontan procedure 10.5 years, range 4-17 years) were enrolled in this study. Hepatic assessment was performed by ultrasonography, computed tomography (CT), and transient elastography (TE) with biochemical tests, echocardiography, and cardiac catheterization...
August 29, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30101859/three-novel-mutations-in-fbn1-and-tgfbr2-in-patients-with-the-syndromic-form-of-thoracic-aortic-aneurysms-and-dissections
#16
Yingxi Cao, Hu Tan, Zhuo Li, Siyuan Linpeng, Xigui Long, Desheng Liang, Lingqian Wu
There are many inherited disorders associated with thoracic aortic aneurysms and dissections (TAADs), like Marfan syndrome and Loeys-Dietz syndrome (LDS). The 4 patients in this study all had TAADs and were initially diagnosed with suspected Marfan syndrome. We collected peripheral blood samples from the patients and their family members and then attempted to identify the causal mutation using different methods including PCR, Sanger sequencing, and next generation sequencing. We identified 3 novel heterozygous mutations including 2 splicing mutations of FBN1 and 1 missense mutation of TGFBR2 in our patients...
August 11, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30101858/phenotypic-screening-using-patient-derived-induced-pluripotent-stem-cells-identified-pyr3-as-a-candidate-compound-for-the-treatment-of-infantile-hypertrophic-cardiomyopathy
#17
Taku Sakai, Atsuhiko T Naito, Yuki Kuramoto, Masamichi Ito, Katsuki Okada, Tomoaki Higo, Akito Nakagawa, Masato Shibamoto, Toshihiro Yamaguchi, Tomokazu Sumida, Seitaro Nomura, Akihiro Umezawa, Shigeru Miyagawa, Yoshiki Sawa, Hiroyuki Morita, Jong-Kook Lee, Ichiro Shiojima, Yasushi Sakata, Issei Komuro
Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by hypertrophy of the myocardium. Some of the patients are diagnosed for HCM during infancy, and the prognosis of infantile HCM is worse than general HCM. Nevertheless, pathophysiology of infantile HCM is less investigated and remains largely unknown. In the present study, we generated induced pluripotent stem cells (iPSCs) from two patients with infantile HCM: one with Noonan syndrome and the other with idiopathic HCM. We found that iPSC-derived cardiomyocytes (iPSC-CMs) from idiopathic HCM patient were significantly larger and showed higher diastolic intracellular calcium concentration compared with the iPSC-CMs from healthy subject...
August 11, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30101857/a-multiple-biomarker-approach-in-patients-with-cardiac-sarcoidosis
#18
Takatoyo Kiko, Akiomi Yoshihisa, Yuki Kanno, Tetsuro Yokokawa, Satoshi Abe, Makiko Miyata-Tatsumi, Tomofumi Misaka, Masayoshi Oikawa, Atsushi Kobayashi, Takafumi Ishida, Yasuchika Takeishi
Sarcoidosis is a systemic granulomatous disease including heart (cardiac sarcoidosis, CS). It has recently been reported that isolated CS, which presenting primarily cardiac symptoms without clinical evidence of sarcoid involvement in other organs. Diagnostic and prognostic biomarkers of CS, especially in isolated CS, have not yet been established.We studied plasma levels of angiotensin-converting enzyme (ACE), soluble interleukin-2 receptor (sIL-2R), B-type natriuretic peptide (BNP) and cardiac troponin I (cTnI) in consecutive 172 patients with diagnosed sarcoidosis...
August 11, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30101856/a-novel-bioabsorbable-sheet-that-delivers-nf-%C3%AE%C2%BAb-decoy-oligonucleotide-restrains-abdominal-aortic-aneurysm-development-in-rats
#19
Shouta Akimoto, Jun-Ichi Suzuki, Norio Aoyama, Ryota Ikeuchi, Hajime Watanabe, Hiroyuki Tsujimoto, Kouji Wakayama, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Issei Komuro
For the suppression of inflammation in the aneurysm development, we focused on inhibition of an important transcription factor, nuclear factor-kappa B (NF-κB), using a decoy strategy. We newly developed a novel bioabsorbable sheet that delivers NF-κB decoy oligodeoxynucleotide (ODN).We treated 5-week-old SD rats that were induced with abdominal aortic aneurysm (AAA) using 0.5 M CaCl2 with an NF-κB decoy sheet. Four weeks after AAA induction, aortic tissue was excised for further examinations. We showed that this bioabsorbable sheet could deliver the decoy ODN into the target tissues and dissolve within a week...
August 11, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30101855/outcomes-in-patients-with-critical-limb-ischemia-due-to-arteriosclerosis-obliterans-who-did-not-undergo-arterial-reconstruction
#20
Daisuke Akagi, Katsuyuki Hoshina, Atsushi Akai, Kota Yamamoto
The prevalence of arteriosclerosis obliterans (ASO) and critical limb ischemia (CLI) is currently increasing, and arterial reconstruction is often attempted to salvage the limb. Some patients cannot undergo attempted revascularization because of contraindications, and they only receive conservative treatment. In this study, we investigate the comorbidities and survival rates of patients with CLI who receive conservative treatment. Thirty-five patients with CLI due to ASO, who had not undergone revascularization surgery (C group), were enrolled...
August 11, 2018: International Heart Journal
journal
journal
41021
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"