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International Heart Journal

Tsukasa Oshima, Masayasu Ikutomi, Hiroki Shinohara, Jumpei Ishiwata, Keiko Fukino, Toshihiro Amaki, Fumitaka Nakamura
Thrombotic microangiopathy (TMA) is a rare but lethal multisystem disease characterized by peripheral thrombocytopenia, microangiopathic hemolytic anemia, fever, and various stages of renal and neurological dysfunctions.(1,2)) The causes of TMA are mainly thrombotic thrombocytopenic purpura (TTP) or hemolytic-uremic syndrome (HUS), and cases of TMA related to myelodysplastic syndrome (MDS) are quite rare. Herein, we report a case of acute myocardial infarction (AMI) caused by TMA which is strongly suspected to have a relationship to MDS, and discuss the treatment of our patient who needed antiplatelet or anticoagulant therapy after AMI, while on the other hand, had pancytopenia and a bleeding event due to MDS...
September 28, 2016: International Heart Journal
Yusuke Adachi, Kenichi Sakakura, Hiroshi Wada, Hiroshi Funayama, Tomio Umemoto, Hideo Fujita, Shin-Ichi Momomura
Revascularization therapy such as percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) should be considered for heart failure with reduced ejection fraction (HFrEF). However, revascularization therapy does not always improve left ventricular ejection fraction (LVEF). The purpose of this study was to investigate the determinants of LVEF improvement following revascularization in HFrEF patients. From 2,229 consecutive decompensated heart failure patients, a total of 47 HFrEF patients who underwent revascularization were included in the analysis...
September 28, 2016: International Heart Journal
Xiaoyun Liu, Ningling Sun, Tao Yu, Fangfang Fan, Meili Zheng, Geng Qian, Binyan Wang, Yu Wang, Genfu Tang, Jianping Li, Xianhui Qin, Fanfan Hou, Xiping Xu, Xinchun Yang, Yundai Chen, Xiaobin Wang, Yong Huo
This study aimed to investigate the independent and joint association of blood pressure (BP), homocysteine (Hcy), and fasting blood glucose (FBG) levels with brachial-ankle pulse wave velocity (baPWV, a measure of arterial stiffness) in Chinese hypertensive adults.The analyses included 3967 participants whose BP, Hcy, FBG, and baPWV were measured along with other covariates. Systolic BP (SBP) was analyzed as 3 categories (SBP < 160 mmHg; 160 to 179 mmHg; ≥ 180 mmHg); Hcy as 3 categories (< 10 μmol/L; 10 to 14...
September 28, 2016: International Heart Journal
Toshihisa Ishida, Shin-Ichiro Miura, Kanta Fujimi, Takashi Ueda, Yoko Ueda, Takuro Matsuda, Maaya Sakamoto, Tadaaki Arimura, Yuhei Shiga, Ken Kitajima, Keijiro Saku
Visit-to-visit variability (VVV) in blood pressure (BP) has been shown to be a predictor of cardiovascular events. It is unknown whether CR can improve VVV in BP as well as reducing BP. We enrolled 84 patients who had cardiovascular disease (CVD) and participated in a 3-month CR program. We measured systolic and diastolic BP (SBP and DBP), pulse pressure (PP), and heart rate (HR) before exercise training at each visit and determined VVV in BP or HR expressed as the standard deviation of the average BP or HR...
September 28, 2016: International Heart Journal
Teruhiko Imamura, Koichiro Kinugawa, Daisuke Nitta, Issei Komuro
The vasopressin type-2 antagonist tolvaptan (TLV) has clinical advantages including amelioration of congestion and normalization of hyponatremia in patients with decompensated heart failure (HF). However, there have been no studies on the cost-effectiveness of TLV therapy. We enrolled 60 consecutive hospitalized patients with stage D HF who received TLV [TLV (+) group], and 60 propensity score-matched HF patients without TLV treatment [TLV (-) group]. We excluded 54 patients who died or received cardiac replacement therapy within 1 year, and finally enrolled 32 patients who received TLV and 34 who did not, who were followed for > 1 year...
September 28, 2016: International Heart Journal
Koichi Kimura, Hiroyuki Morita, Akinori Nakamura, Katsu Takenaka, Masao Daimon
No abstract text is available yet for this article.
September 28, 2016: International Heart Journal
Tomomi Watanabe, Yoshiyuki Furuse, Yasutoshi Ohta, Masahiko Kato, Toshihide Ogawa, Kazuhiro Yamamoto
Non-ST segment elevation acute coronary syndrome (NSTE-ACS) can be difficult to diagnose accurately, especially in the hyper-acute phase. Non-ECG-gated contrast-enhanced computed tomography (non-ECG-gated CE-CT) has been used in many institutions for screening acute chest pain. Although early defects (EDs) observed in non-ECG-gated CE-CT have been reported as a sign of acute myocardial ischemia, the precise diagnostic value of this sign for acute coronary syndrome has not been fully elucidated. We investigated the usefulness of non-ECG-gated CE-CT for the diagnosis of NSTE-ACS...
September 28, 2016: International Heart Journal
Jin-Tao Wu, Shan-Ling Wang, Ying-Jie Chu, De-Yong Long, Jian-Zeng Dong, Xian-Wei Fan, Hai-Tao Yang, Hong-Yan Duan, Li-Jie Yan, Peng Qian, Chao-Kuan Yang
Interatrial block (IAB) is associated with an increased risk of atrial fibrillation (AF). The aim of this retrospective study was to investigate the association of a combination of IAB and the CHADS2 score, an AF-related risk score for ischemic stroke, with new onset AF in patients in sinus rhythm. A total of 1,571 patients (803 males, 768 females; mean age: 58 ± 16 years) were included in this study. IAB was defined as a P-wave duration > 120 ms in the 12-lead electrocardiogram, and a high CHADS2 score as ≥ 2 points...
September 28, 2016: International Heart Journal
Ruoxi Zhang, Shuyuan Chen, Hui Zhang, Wei Wang, Jianpang Xing, Yu Wang, Bo Yu, Jingbo Hou
This retrospective study aimed to investigate the predictive value of biomarkers for in-hospital mortality of patients with Stanford type A acute aortic dissection (AAD).AAD is a life-threatening disease with an incidence of about 2.6-3.6 cases per 100,000/year.A total of 67 consecutive Stanford type A AAD patients admitted to hospital were divided into a deceased group and survival group. The baseline information of the patients between two groups was systematically compared, followed by examination of the electrocardiograms (ECG)...
September 28, 2016: International Heart Journal
Hiroaki Wakakuri, Shunichi Nakamura, Kouichi Utsumi, Wataru Shimizu, Masahiro Yasutake
Fabry disease, an X-linked lysosomal storage disorder due to α-galactosidase A deficiency, is associated with dysfunction of various cell types and results in a systemic vasculopathy. We describe a 29-year-old woman with Fabry disease presenting with severe cardiac and renal manifestations. Gene analysis demonstrated a novel mutation (K391E) in the GLA gene. Enzyme replacement therapy (ERT) was started with agalsidase-β after confirming the diagnosis of Fabry disease, resulting in normalization of LV systolic function and improvement of renal function...
September 28, 2016: International Heart Journal
Teruhiko Imamura, Koichiro Kinugawa
No abstract text is available yet for this article.
September 28, 2016: International Heart Journal
Satoshi Ono, Itaru Saito, Yuichi Ikeda, Mitsuhiro Fujishiro, Issei Komuro, Kazuhiko Koike
The management of antithrombotics during the periendoscopic period is traditionally represented as a doubleedged sword for cardiologists and endoscopists. Appropriate administration prevents thromboembolic events, whereas excessive administration provokes bleeding events. Therefore, cardiologists and endoscopists must consider the risks of bleeding and thromboembolism in individual cases, before deciding whether to continue antithrombotic use. Several guidelines exist concerning antithrombotic management in Asian and Western countries...
September 28, 2016: International Heart Journal
Hirofumi Maeba, Takeshi Seno, Ichiro Shiojima
A 22-year-old male was admitted to our hospital with deep vein thrombosis that was complicated by antithrombin deficiency. This deficiency was refractory to anticoagulation therapy. Although catheter-directed thrombolysis could not reperfuse the total occlusion in the left deep vein, a combination of thrombectomy, catheter-directed thrombolysis, and antithrombin concentrate treatment was able to dissolve the clots and ameliorate the blood flow into the left deep vein. Antithrombin concentrate administration would be effective in the treatment of antithrombin deficiency with medical refractory deep vein thrombosis...
September 28, 2016: International Heart Journal
F Daniel Ramirez, Bruce M Jamison, Benjamin Hibbert
Aortitis is broadly divided into infectious and non-infectious etiologies, each with distinct treatment implications. We present the case of a patient who sustained a type A aortic dissection during urgent coronary angiography for acute coronary syndrome. Clinical findings and events during the procedure raised suspicion for an underlying vascular disorder; however, the diagnosis of staphylococcal aortitis was not made until pathological examination of resected tissue. Clues to the diagnosis of infectious aortitis noted throughout the patient's clinical course are detailed as are potential consequences of diagnostic delays and treatment decisions, underscoring the difficulties in recognizing and managing the condition...
September 28, 2016: International Heart Journal
Teruhiko Imamura, Koichiro Kinugawa
Tolvaptan (TLV), an arginine vasopressin type 2 antagonist, has been shown to play a role in ameliorating symptomatic congestion and normalizing diluted hyponatremia in patients with congestive heart failure (HF). However, most evidence was derived from patients with HF with reduced ejection fraction (HFrEF), and the clinical efficacy of TLV in patients with HF with preserved ejection fraction (HFpEF) remains uncertain. In this study, we retrospectively enrolled 60 in-hospital patients with stage D HF, who had received TLV to treat symptomatic congestion at our institute between 2011 and 2013...
September 28, 2016: International Heart Journal
Yasuhiro Nishiyama, Hiroshi Niiyama, Haruhito Harada, Atsushi Katou, Noriko Yoshida, Hisao Ikeda
Red blood cell distribution width (RDW) can predict mortality in cardiovascular disease. However, the underlying mechanisms of the beneficial prognostic marker remain unknown. The purpose of this study was to investigate whether the RDW is related to impaired exercise tolerance and exercise training (ET) effect on RDW in patients with coronary artery disease (CAD).Seventy-eight patients who underwent ET by supervised bicycle ergometer during 3 weeks served as the ET group whereas 30 patients who did not undergo ET were the control group...
September 28, 2016: International Heart Journal
Göksel Çinier, Ahmet Öz, Ahmet Ilker Tekkesin, Mert İlker Hayıroğlu, Muhammed Keskin, Şahin Avsar
Factor V Leiden (FVL) mutation is the most common hereditary thrombophilia. Association of this mutation with venous thrombosis is well established. However, there are several conflicting results regarding the association of FVL with arterial thrombosis, acute coronary syndrome, and intracardiac thrombosis. In this case report, we present a 44-yearold male patient with a medical history of both arterial and venous thrombosis who came to our emergency department with chest pain. After the initial evaluation he was diagnosed as having acute coronary syndrome and transthoracic echocardiography revealed an intracardiac apical thrombus...
September 28, 2016: International Heart Journal
Tazuru Igarashi, Shinichi Niwano, Hidehira Fukaya, Tomoharu Yoshizawa, Hironori Nakamura, Tamami Fujiishi, Naruya Ishizue, Jun Oikawa, Jun Kishihara, Masami Murakami, Hiroe Niwano, Junya Ako
Discrimination between paroxysmal and persistent atrial fibrillation (PAF and persistent AF) is important for determining the therapeutic strategy in patients with new-onset AF. We evaluated various clinical factors and P wave morphology to discriminate PAF and persistent AF patients in patients with new-onset AF.The study population consisted of 79 patients with new-onset AF (70.3 ± 10.8 years, female:male 33:46) who were retrospectively selected from 8,632 AF patients in the Kitasato University Hospital ECG storing system...
September 28, 2016: International Heart Journal
Po-Tseng Lee, Ting-Hsing Chao, Ya-Ling Huang, Sheng-Hsiang Lin, Wei-Ming Wang, Wen-Huang Lee, Chen-Wei Huang, Cheng-Han Lee, Ju-Yi Chen, Chih-Chan Lin, Ping-Yen Liu, Shih-Hung Chan, Yen-Wen Liu, Wei-Chuan Tsai, Li-Jen Lin, Liang-Miin Tsai, Yi-Heng Li
It is unknown whether there has been any change in the causes of death for acute ST-segment elevation myocardial infarction (STEMI) in the era of aggressive reperfusion. We analyzed the direct causes of in-hospital death in patients with STEMI treated with primary percutaneous coronary intervention (PCI) in a tertiary referral center over the past 10 years.We retrospectively analyzed 878 STEMI patients treated with primary PCI in our hospital between January 2005 and December 2014. There were no significant changes in the age and sex of patients, but the prevalence of hypertension and smoking decreased...
September 28, 2016: International Heart Journal
Yusuke Namba, Soichiro Fuke, Yuya Kashihara, Masamichi Tanaka, Akihisa Yumoto, Hironori Saito, Tetsuya Sato
The usefulness of coronary magnetic resonance angiography (cMRA) has been reported, although the difference in the diagnostic accuracy of different protocols has not been established.We compared conventional coronary angiography (CAG) and cMRA, conducted within 6 months in 24 consecutive patients between September 2012 and July 2014. Three cMRA protocols were examined, cMRA1, free-breathing wholeheart coronary angiography (WHCA) without contrast; cMRA2, free-breathing WHCA with contrast; and cMRA3, breath-hold steady-state free precession with contrast using a 3...
September 28, 2016: International Heart Journal
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