Read by QxMD icon Read

Psychiatry Investigation

Ju-Wan Kim, Kyung-Yeol Bae, Sung-Wan Kim, Hee-Ju Kang, Il-Seon Shin, Jin-Sang Yoon, Jae-Min Kim
Major depressive disorder is often resistant to antidepressant treatment. Repetitive transcranial magnetic stimulation (rTMS) has been used in treatment-resistant depression (TRD). Known adverse events of rTMS include transient headache, local pain, syncope, seizure induction, and hypomania induction. This report outlines a patient with TRD who unexpectedly improved following a seizure during the course of rTMS, which has never been reported.
July 2016: Psychiatry Investigation
Young Sup Woo, Joo Eon Park, Do-Hoon Kim, Inki Sohn, Tae-Yeon Hwang, Young-Min Park, Duk-In Jon, Jong-Hyun Jeong, Won-Myong Bahk
OBJECTIVE: The purpose of this study was to investigate the efficacy and tolerability of atypical antipsychotics (AAPs) with augmentation by blonanserin in schizophrenic patients. METHODS: aA total of 100 patients with schizophrenia who were partially or completely unresponsive to treatment with an AAP were recruited in this 12-week, open-label, non-comparative, multicenter study. Blonanserin was added to their existing AAP regimen, which was maintained during the study period...
July 2016: Psychiatry Investigation
Soojin Kim, Chul-Hyun Cho, Dongho Geum, Heon-Jeong Lee
OBJECTIVE: Previous studies have suggested an association between CACNA1C and susceptibility of bipolar disorder. In this study, we examined the association of CACNA1C variants with bipolar disorder in the Korean population. METHODS: We selected 2 CACNA1C single nucleotide polymorphisms (SNPs), namely, rs723672 and rs1051375, based on their functions and minor allele frequencies described in previous studies. Genotypes of these 2 SNPs were analyzed by extracting DNA from blood samples collected from 287 patients with bipolar disorder and 340 healthy controls...
July 2016: Psychiatry Investigation
Eun-Jin Cheon, Jun-Yeob Lee, Joong-Hyeon Choi, Young-Ji Lee, Bon-Hoon Koo
OBJECTIVE: The purpose of this study was to compare duloxetine monotherapy to combination therapy with other antidepressants in patients with major depressive disorder in a clinical, real world setting. METHODS: An eight-week, retrospective, multi-center study of outpatients with major depressive disorder was undertaken. After screening 415 patients, enrolled in this study from July 2009 to June 2014 were 82 patients from among three centers who had been taking duloxetine with or without other antidepressant and not administered with atypical antipsychotics...
July 2016: Psychiatry Investigation
Woo-Young Jung, Sae-Heon Jang, Sung-Gon Kim, Young-Myo Jae, Bo-Geum Kong, Ho-Chan Kim, Byeong-Moo Choe, Jeong-Gee Kim, Choong-Rak Kim
OBJECTIVE: The aim of the present study was to investigate differences in discontinuation time among antidepressants and total antidepressant discontinuation rate of patients with depression over a 6 month period in a naturalistic treatment setting. METHODS: We reviewed the medical records of 900 patients with major depressive disorder who were initially prescribed only one kind of antidepressant. The prescribed antidepressants and the reasons for discontinuation were surveyed at baseline and every 4 weeks during the 24 week study...
July 2016: Psychiatry Investigation
Manu Kumar, Chakra Dhar Tripathi, Veena Verma, Biswa Mohan Padhy, Girish Gulab Meshram, B Abhilash
OBJECTIVE: To determine the predictive validity of some of the commonly employed models of mania and depression using standard drugs i.e. lithium (70 mg/kg) and lamotrigine (5 mg/kg) in male Wistar rats. METHODS: The depression facet of bipolar disorder was evaluated using forced swim test, tail suspension test, and chronic mild stress test. The models used to evaluate the mania facet of bipolar disorder were isolation-induced aggression test, saccharine preference test, and morphine-sensitized hyperlocomotion test...
July 2016: Psychiatry Investigation
Dilek Unal, Mehmet Fatih Unal, Mehmet Alikasifoglu, Arda Cetinkaya
OBJECTIVE: ObjectiveaaWe evaluated the distribution of alpha-2A adrenergic receptor (ADRA2A) and catechol-o-methyltransferase (COMT) single nucleotide polymorphisms (SNPs) among ADHD subtypes and other homogeneous patient populations including treatment-resistant cases and patients with high symptom severity. METHODS: Methodsaa121 ADHD patients aged 6-18 years were included in the study. Diagnosis and subtypes designation were confirmed using the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS) and symptoms were evaluated using the Conners' Parent (CPRS) and Teacher Rating Scales (CTRS)...
July 2016: Psychiatry Investigation
Süleyman Demir, Mahmut Bulut, Abdullah Atli, İbrahim Kaplan, Mehmet Cemal Kaya, Yasin Bez, Pınar Güzel Özdemir, Aytekin Sır
OBJECTIVE: Many neurochemical systems have been implicated in the development of Posttraumatic Stress Disorder (PTSD). The prolidase enzyme is a cytosolic exopeptidase that detaches proline or hydroxyproline from the carboxyl terminal position of dipeptides. Prolidase has important biological effects, and to date, its role in the etiology of PTSD has not been studied. In the present study, we aimed to evaluate prolidase activity in patients with PTSD. METHODS: The study group consisted of patients who were diagnosed with PTSD after the earthquake that occurred in the province of Van in Turkey in 2011 (n=25); the first control group consisted of patients who experienced the earthquake but did not show PTSD symptoms (n=26) and the second control group consisted of patients who have never been exposed to a traumatic event (n=25)...
July 2016: Psychiatry Investigation
Seiichiro Tarutani, Hiroki Kikuyama, Munehiro Ohta, Tetsufumi Kanazawa, Takehiko Okamura, Hiroshi Yoneda
OBJECTIVE: Medication adherence is important in the treatment of schizophrenia, and critical periods during treatment may be associated with relapse. However, the relationship between adherence and duration of outpatient treatment (DOT) remains unclear. The authors aimed to clarify the relationship between adherence and DOT at a psychiatric hospital in Japan. METHODS: For outpatients with schizophrenia who regularly visit Shin-Abuyama hospital, the authors conducted a single questionnaire survey (five questions covering gender, age, DOT, medication shortages, and residual medication) over one month period...
July 2016: Psychiatry Investigation
Yu Jin Jang, Suk-Hoon Kang, Hae Gyung Chung, Jin Hee Choi, Tae Yong Kim, Hyung Seok So
OBJECTIVE: Post-traumatic stress disorder (PTSD) is often missed or incorrectly diagnosed in primary care settings. Although brief screening instruments may be useful in detecting PTSD, an adequate validation study has not been conducted with older adults. This study aimed to evaluate the reliability and validity of the Korean version of the primary care PTSD screen (PC-PTSD) and single-item PTSD screener (SIPS) in elderly veterans. METHODS: The PC-PTSD and SIPS assessments were translated into Korean, with a back-translation to the original language to verify accuracy...
July 2016: Psychiatry Investigation
Lien-Cheng Kao, Yu-Wen Liu, Nian-Sheng Tzeng, Terry B J Kuo, San-Yuan Huang, Chuan-Chia Chang, Hsin-An Chang
OBJECTIVE: Anxiety trait, anxiety and depression states have all been reported to increase risks for cardiovascular disease (CVD), possibly through altering cardiac autonomic regulation. Our aim was to investigate whether the relationship between harm avoidance (HA, an anxiety-related personality trait) and cardiac autonomic regulation is independent of anxiety and depression states in healthy adults. METHODS: We recruited 535 physically and mentally healthy volunteers...
July 2016: Psychiatry Investigation
Meerae Lim, Soojung Lee, Jong-Ik Park
OBJECTIVE: A considerable proportion of suicide attempts are the result of sudden desires. Understanding such impulsive suicide attempts is necessary for effective interventions. We evaluated the impulsivity of suicide attempters treated in emergency rooms. The aim of the study was to identify the characteristics of impulsive suicide attempts by comparing these individuals to those who attempted to commit suicide in a non-impulsive manner. METHODS: This study analyzed suicide attempters who visited the emergency departments of seven selected university hospitals...
July 2016: Psychiatry Investigation
Kyoung Min Shin, Sun-Mi Cho, Yun Mi Shin, Kyung Soon Park
OBJECTIVE: Peer relationships are one of the important factors in children's development. The present study examines the relationship between the effects of early peer relationships and adolescent psychological adjustment. METHODS: The first survey took place from 1998 to 2000, and a follow-up assessment obtained data in 2006, as the original participants reached 13-15 years of age. The first assessment used the Korean version of the Child Behavior Checklist (K-CBCL) and simple questions about peer relationships to evaluate the participants...
July 2016: Psychiatry Investigation
Soon-Ho Seol, Jun Soo Kwon, Yang Yeol Kim, Sung Nyun Kim, Min-Sup Shin
OBJECTIVE: Cognitive behavioral therapy (CBT) is regarded as one of the most effective intervention for obsessive-compulsive disorder (OCD). However, many patients remain untreated or inadequately treated due to time or geographical constraints. The purpose of this study was to develop an internet-based CBT (ICBT) for OCD, and to examine its efficacy in the Korean clinical setting. METHODS: The ICBT program ('COT') was developed from the same OCD manual in the standard CBT intervention...
July 2016: Psychiatry Investigation
Andrea Amerio, Matteo Tonna, Anna Odone, S Nassir Ghaemi
No abstract text is available yet for this article.
May 2016: Psychiatry Investigation
Yoo Hyun Um, Tae-Won Kim, Jong-Hyun Jeong, Ho-Jun Seo, Jin-Hee Han, Seung-Chul Hong, Won-Sang Jung, Woo Hee Choi, Chang-Uk Lee, Hyun Kook Lim
Parkinson's disease dementia (PDD) is notorious for its debilitating clinical course and high mortality rates. Consequently, various attempts to investigate predictors of cognitive decline in Parkinson's disease (PD) have been made. Here we report a case of a 75-year-old female patient with PD who visited the clinic with complaints of recurrent visual hallucinations and cognitive decline, whose symptoms were ameliorated by the titration of rivastigmine. Imaging results showed pronounced diffuse cortical amyloid deposition evidenced by 18F-florbetaben amyloid positron emission tomography (PET) imaging...
May 2016: Psychiatry Investigation
Subin Park, Hokwang Song
Drug abuse has been widely linked to suicide risk. We examined the factors that affect adolescent drug users' suicide attempts in South Korea. This study analyzed the data of 311 adolescents who had used drugs such as inhalants, psychotropic drugs, and marijuana (195 males and 116 females). Among 311 subjects, 109 (35.0%) had attempted suicide during the last 12 months. After adjusting for other variables, depressive mood (OR=19.79) and poly-drug use (OR=2.79), and low/middle levels of academic achievement compared with a high level (OR=3...
May 2016: Psychiatry Investigation
Seung-Hwan Lee, Sangrae Kim, Mi-Seon Shim, Do-Won Kim, Chang-Hwan Im
OBJECTIVE: Healthy individuals show stronger gamma-band activities (GBAs) for socially relevant stimuli (human faces) than for non-relevant ones. This study aimed to examine whether this gamma-band preference occurs in patients with schizophrenia. METHODS: EEG was recorded for 24 patients with schizophrenia and 23 healthy controls while they viewed pictures of human faces, chairs, and nature scenes. The spectral powers of high-beta (20-30 Hz) and gamma (30-80 Hz) frequencies were analyzed along 3 midline cortical regions, and phase synchronization was calculated...
May 2016: Psychiatry Investigation
Tae-Young Hwang, Inn-Sook Ahn, Seonwoo Kim, Doh Kwan Kim
OBJECTIVE: This study compares the efficacy of the cholinesterase inhibitor (ChEI) galantamine on cognition in patients with mild-to-moderate Alzheimer's dementia (AD) who were either naïve to ChEI drugs or who had failed a trial of the ChEI donepezil. METHODS: Outpatients with AD were sequentially referred for screening and enrollment. Current outpatients who had taken donepezil for at least 6 months without demonstrated efficacy on cognition were switched to galantamine (switched group)...
May 2016: Psychiatry Investigation
Ye-Ha Jung, Ul Soon Lee, Joon Hwan Jang, Do-Hyung Kang
OBJECTIVE: It has been known that mind-body training (MBT) can affect personality and behavior system as well as emotional well-being, but different effects of MBT on them has not been reported according to BDNF genetic polymorphism. METHODS: Healthy subjects consisted of 64 subjects and the MBT group who practiced meditation regularly consisted of 72 practitioners. Participants completed neuroticism-extraversion-openness (NEO) Five-Factor Inventory and Behavioral Activation System/Behavioral Inhibition System (BAS/BIS) scales...
May 2016: Psychiatry Investigation
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"