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Cellular & Molecular Immunology

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https://www.readbyqxmd.com/read/29769660/gaiting-the-gut
#1
Barsanjit Mazumder
No abstract text is available yet for this article.
May 16, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29769659/mannose-6-phosphate-receptor-a-novel-regulator-of-t-cell-immunity
#2
Anjuman Ara, Khawaja Ashfaque Ahmed, Jim Xiang
No abstract text is available yet for this article.
May 16, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29769658/global-transcriptional-changes-in-response-to-cgamp-depend-on-sting-in-human-thp-1-cells
#3
Anne Louise Hansen, Aske M Brandtoft, Mette Nyegaard, Anne L Thielke, David Olagnier, Christian K Holm
No abstract text is available yet for this article.
May 16, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29769657/correction-to-aryl-hydrocarbon-receptor-signaling-promotes-ormdl3-dependent-generation-of-sphingosine-1-phosphate-by-inhibiting-sphingosine-1-phosphate-lyase
#4
Hsueh-Chun Wang, Tzu-Hsuan Wong, Li-Ting Wang, Hsiang-Han Su, Hsiu-Yueh Yu, Ai-Hsuan Wu, Yu-Chun Lin, Hua-Ling Chen, Jau-Ling Suen, Shih-Hsien Hsu, Li-Chen Chen, Yufeng Zhou, Shau-Ku Huang
In this article, published online 23 March 2018, the affiliation 10 of Zhou Y was incorrect. The affiliation should be "Children's Hospital and Institute of Biomedical Sciences, Fudan University. Key Laboratory of Neonatal Disease, Ministry of Health, 201102, Shanghai, China." The authors regret the errors.
May 16, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29735980/metabolic-modulation-of-acetaminophen-induced-hepatotoxicity-by-osteopontin
#5
Yankai Wen, Chenchen Wang, Jinyang Gu, Chang Yu, Kaixia Wang, Xuehua Sun, Yun Sun, Hailong Wu, Ying Tong, Qiang Xia, Xiaoni Kong
Induction of osteopontin (OPN), a well-known pro-inflammatory molecule, has been observed in acetaminophen (APAP)-induced hepatotoxicity. However, the precise cell source for OPN induction and its role during APAP-induced hepatotoxicity has not been fully explored. By employing a hepatotoxic mouse model induced by APAP overdose, we demonstrate that both serum and hepatic OPN levels were significantly elevated in response to APAP treatment. Our in vivo and in vitro studies clearly indicated that the induced expression of hepatic OPN was mainly located in necrosis areas and produced by dying or dead hepatocytes...
May 7, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29735979/uracil-dna-glycosylase-is-not-implicated-in-the-choice-of-the-dna-repair-pathway-during-b-cell-class-switch-recombination
#6
Nour Ghazzaui, Hussein Issaoui, Alexis Saintamand, Yves Denizot, François Boyer
No abstract text is available yet for this article.
May 7, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29735978/plasma-phospholipid-transfer-protein-pltp-as-an-emerging-determinant-of-the-adaptive-immune-response
#7
Catherine Desrumaux, Laurent Lagrost
No abstract text is available yet for this article.
May 7, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29735977/increased-tim-3-expression-alleviates-liver-injury-by-regulating-macrophage-activation-in-mcd-induced-nash-mice
#8
Xianhong Du, Zhuanchang Wu, Yong Xu, Yuan Liu, Wen Liu, Tixiao Wang, Chunyang Li, Cuijuan Zhang, Fan Yi, Lifen Gao, Xiaohong Liang, Chunhong Ma
As an immune checkpoint, Tim-3 plays roles in the regulation of both adaptive and innate immune cells including macrophages and is greatly involved in chronic liver diseases. However, the precise roles of Tim-3 in nonalcoholic steatohepatitis (NASH) remain unstated. In the current study, we analyzed Tim-3 expression on different subpopulations of liver macrophages and further investigated the potential roles of Tim-3 on hepatic macrophages in methionine and choline-deficient diet (MCD)-induced NASH mice. The results of flow cytometry demonstrated the significantly increased expression of Tim-3 on all detected liver macrophage subsets in MCD mice, including F4/80+ CD11b+ , F4/80+ CD68+ , and F4/80+ CD169+ macrophages...
May 7, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29706647/the-microbiome-and-autoimmunity-a-paradigm-from-the-gut-liver-axis
#9
REVIEW
Bo Li, Carlo Selmi, Ruqi Tang, M E Gershwin, Xiong Ma
Microbial cells significantly outnumber human cells in the body, and the microbial flora at mucosal sites are shaped by environmental factors and, less intuitively, act on host immune responses, as demonstrated by experimental data in germ-free and gnotobiotic studies. Our understanding of this link stems from the established connection between infectious bacteria and immune tolerance breakdown, as observed in rheumatic fever triggered by Streptococci via molecular mimicry, epitope spread and bystander effects...
April 30, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29670279/safety-pharmacokinetics-and-biomarkers-of-f-652-a-recombinant-human-interleukin-22-dimer-in-healthy-subjects
#10
Kai-Yang Tang, Jason Lickliter, Zhi-Hua Huang, Zong-Shu Xian, Han-Yang Chen, Cheng Huang, Chong Xiao, Yu-Peng Wang, Ying Tan, Lin-Feng Xu, Yu-Liang Huang, Xiao-Qiang Yan
F-652 is a recombinant fusion protein consisting of two human interleukin-22 (IL-22) molecules linked to an immunoglobulin constant region (IgG2 -Fc). IL-22 plays critical roles in promoting tissue repair and suppressing bacterial infection. The safety, pharmacokinetics (PK), tolerability, and biomarkers of F-652 were evaluated following a single dose in healthy male volunteers in a randomized, double-blind, placebo-controlled study. Following single-dose subcutaneous (SC) injection of F-652 at 2.0 µg/kg into healthy subjects, six out of six subjects experienced delayed injection site reactions, which presented as erythematous and/or discoid eczematous lesions 10 to 17 days post-dosing...
April 18, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29670278/blt1-in-dendritic-cells-promotes-th1-th17-differentiation-and-its-deficiency-ameliorates-tnbs-induced-colitis
#11
Jinfeng Zhou, Weiming Lai, Wanjie Yang, Juping Pan, Hu Shen, Yingying Cai, Cuixia Yang, Ningjia Ma, Yue Zhang, Ru Zhang, Xin Xie, Zhongjun Dong, Yuan Gao, Changsheng Du
Leukotriene B4 (LTB4) synthesis is enhanced in the colonic mucosa in patients with inflammatory bowel disease (IBD). BLT1, a high-affinity receptor for LTB4, exhibits no effect on the progression of dextran sodium sulfate (DSS)-induced colitis, which mostly relies on innate immunity. Here, we reported that BLT1 regulates trinitrobenzene sulfonic acid (TNBS)-induced colitis, which reflects CD4+ T-cell-dependent adaptive immune mechanisms of IBD. We found that BLT1 signaling enhanced the progression of colitis through controlling the production of proinflammatory cytokines by dendritic cells (DCs) and modulating the differentiation of Th1 and Th17...
April 18, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29658510/a-protocol-for-quantizing-total-bacterial-16s-rdna-in-plasma-as-a-marker-of-microbial-translocation-in-vivo
#12
Wei Jiang
No abstract text is available yet for this article.
April 16, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29628498/tumor-infiltrating-b-cells-their-role-and-application-in-anti-tumor-immunity-in-lung-cancer
#13
REVIEW
Si-Si Wang, Wei Liu, Dalam Ly, Hao Xu, Limei Qu, Li Zhang
Evidence indicates that lung cancer development is a complex process that involves interactions between tumor cells, stromal fibroblasts, and immune cells. Tumor-infiltrating immune cells play a significant role in the promotion or inhibition of tumor growth. As an integral component of the tumor microenvironment, tumor-infiltrating B lymphocytes (TIBs) exist in all stages of cancer and play important roles in shaping tumor development. Here, we review recent clinical and preclinical studies that outline the role of TIBs in lung cancer development, assess their prognostic significance, and explore the potential benefit of B cell-based immunotherapy for lung cancer treatment...
April 8, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29628497/activated-pancreatic-stellate-cells-inhibit-nk-cell-function-in-the-human-pancreatic-cancer-microenvironment
#14
LETTER
Qiang Huang, Mei Huang, Futao Meng, Rui Sun
No abstract text is available yet for this article.
April 8, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29622799/low-dose-decitabine-enhances-the-effect-of-pd-1-blockade-in-colorectal-cancer-with-microsatellite-stability-by-re-modulating-the-tumor-microenvironment
#15
Ganjun Yu, Yanfeng Wu, Wenying Wang, Jia Xu, Xiaoping Lv, Xuetao Cao, Tao Wan
PD-1 blockade has demonstrated impressive clinical outcomes in colorectal cancers that have high microsatellite instability. However, the therapeutic efficacy for patients with tumors with low microsatellite instability or stable microsatellites needs further improvement. Here, we have demonstrated that low-dose decitabine could increase the expression of immune-related genes such as major histocompatibility complex genes and cytokine-related genes as well as the number of lymphocytes at the tumor site in CT26 colorectal cancer-bearing mice...
April 5, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29622798/cd26-the-emerging-role-of-a-costimulatory-molecule-in-allograft-rejection
#16
EDITORIAL
W Jungraithmayr, N Enz
No abstract text is available yet for this article.
April 5, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29618777/three-macrophage-subsets-are-identified-in-the-uterus-during-early-human-pregnancy
#17
Xiangxiang Jiang, Mei-Rong Du, Min Li, Hongmei Wang
Macrophages are crucial for a successful pregnancy, and malfunctions of decidual macrophages correlate with adverse pregnancy outcomes, such as spontaneous abortion and preeclampsia. Previously, decidual macrophages were often thought to be a single population. In the present study, we identified three decidual macrophage subsets, CCR2-CD11cLO (CD11clow , ~80%), CCR2-CD11cHI (CD11chigh , ~5%), and CCR2+CD11cHI (CD11chigh , 10-15%), during the first trimester of human pregnancy by flow cytometry analysis. CCR2-CD11cLO macrophages are widely distributed in the decidua, while CCR2-CD11cHI and CCR2+CD11cHI macrophages are primarily detected close to extravillous trophoblast cells according to immunofluorescence staining...
April 4, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29588487/trophoblast-derived-cxcl16-induces-m2-macrophage-polarization-that-in-turn-inactivates-nk-cells-at-the-maternal-fetal-interface
#18
Xiao-Qiu Wang, Wen-Jie Zhou, Xin-Xin Hou, Qiang Fu, Da-Jin Li
Decidual macrophages (dMΦ) are distinct from the conventional macrophages present in other tissues and express M2 macrophage markers, but the molecular mechanisms of formation and the roles of M2 MΦ during pregnancy have not been completely elucidated. The crosstalk between decidual natural killer cells (dNK) and dMΦ plays an important role in the maintenance of maternal-fetal immune tolerance. Here, CXCL16 derived from first-trimester trophoblast cells induces the polarization of human M2 macrophages. The M2 MΦ polarized by CXCL16 exhibit decreased interleukin-15 production, which facilitates the inactivation of NK cells...
March 27, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29578534/chemokines-the-past-the-present-and-the-future
#19
EDITORIAL
Peng Tang, Ji Ming Wang
No abstract text is available yet for this article.
March 26, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29578533/microrna-663-induces-immune-dysregulation-by-inhibiting-tgf-%C3%AE-1-production-in-bone-marrow-derived-mesenchymal-stem-cells-in-patients-with-systemic-lupus-erythematosus
#20
Linyu Geng, Xiaojun Tang, Kangxing Zhou, Dandan Wang, Shiying Wang, Genhong Yao, Weiwei Chen, Xiang Gao, Wanjun Chen, Songtao Shi, Nan Shen, Xuebing Feng, Lingyun Sun
Mesenchymal stem cells (MSCs) are critical for immune regulation. Although several microRNAs (miRNAs) have been shown to participate in autoimmune pathogenesis by affecting lymphocyte development and function, the roles of miRNAs in MSC dysfunction in autoimmune diseases remain unclear. Here, we show that patients with systemic lupus erythematosus (SLE) display a unique miRNA signature in bone marrow-derived MSCs (BMSCs) compared with normal controls, among which miR-663 is closely associated with SLE disease activity...
March 26, 2018: Cellular & Molecular Immunology
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