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Cellular & Molecular Immunology

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https://www.readbyqxmd.com/read/30127381/physiological-and-druggable-skipping-of-immunoglobulin-variable-exons-in-plasma-cells
#1
Mohamad Omar Ashi, Nivine Srour, Jean-Marie Lambert, Anne Marchalot, Ophélie Martin, Sandrine Le Noir, Eric Pinaud, Maria Victoria Ayala, Christophe Sirac, Jérôme Saulière, Jérôme Moreaux, Michel Cogné, Laurent Delpy
The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin (Ig) pre-mRNAs. We recently demonstrated that aberrant Ig chains lacking variable (V) domains can be produced after nonsense-associated altered splicing (NAS) events. Remarkably, the expression of these truncated Ig polypeptides heightens endoplasmic reticulum stress and shortens plasma cell (PC) lifespan. Many questions remain regarding the molecular mechanisms underlying this new truncated Ig exclusion (TIE-) checkpoint and its restriction to the ultimate stage of B-cell differentiation...
August 20, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/30127380/human-dendritic-cell-specific-icam-3-grabbing-non-integrin-downstream-signaling-alleviates-renal-fibrosis-via-raf-1-activation-in-systemic-candidiasis
#2
Wen-Yu Chen, Sheng-Yang Wu, Ta-Chun Lin, Shuei-Liong Lin, Betty A Wu-Hsieh
We generated a human dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) transgenic mouse in which renal tubular epithelial cells expressed DC-SIGN. The transgenic mice were infected with Candida albicans intravenously to study how DC-SIGN expression affected the pathogenesis of systemic candidiasis. We discovered that, while C. albicans infection induced renal fibrosis in both transgenic and littermate control mice, the transgenic mice had significantly lower levels of Acta2, Col1a2, Col3a1, and Col4a1 mRNA transcripts compared to the controls...
August 20, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/30127379/deletion-of-the-immunoglobulin-heavy-chain-3-regulatory-region-super-enhancer-affects-somatic-hypermutation-in-b1-b-cells
#3
Issaoui Hussein, Ghazzaui Nour, Boyer François, Denizot Yves, Saintamand Alexis
No abstract text is available yet for this article.
August 20, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/30030493/in-drug-induced-immune-mediated-hepatitis-interleukin-33-reduces-hepatitis-and-improves-survival-independently-and-as-a-consequence-of-foxp3-t-cell-activity
#4
Merylin Cottagiri, Maeva Nyandjo, Matthew Stephens, Joel Mantilla, Hirohisa Saito, Ian R Mackay, Noel R Rose, Dolores B Njoku
Immune-mediated, drug-induced hepatitis is a rare complication of halogenated volatile anesthetic administration. IL-4-regulated Th2-polarized reactions initiate this type and other types of hepatitis, while the mechanisms that regulate the severity remain elusive. IL-33 is an innate, IL-4-inducing, Th2-polarizing cytokine that has been detected in patients with liver failure and has been associated with upregulated ST2+Foxp3+CD4+CD25+ T cells; however, roles for IL-33 in drug-induced hepatitis are unclear...
July 20, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/30002451/emerging-predictors-of-the-response-to-the-blockade-of-immune-checkpoints-in-cancer-therapy
#5
REVIEW
Xiaolei Li, Wenhui Song, Changshun Shao, Yufang Shi, Weidong Han
Checkpoint blockade-based immunotherapy offers new options and powerful weapons for the treatment of cancer, but its efficacy varies greatly among different types of cancer and across individual patients. Thus, the development of the right tools that can be used to identify patients who could benefit from this therapy is of utmost importance in order to maximize the therapeutic benefit, minimize risk of toxicities, and guide combination approaches. Multiple predictors have emerged that are based on checkpoint receptor ligand expression, tumor mutational burden, neoantigen and microsatellite instability, tumor-infiltrating immune cells, and peripheral blood biomarkers...
July 12, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/30002450/failure-of-a-t-cell-regulator-cd6-contributes-to-the-aggravation-of-autoimmune-inflammation
#6
Anja Meyer, David M Kofler
No abstract text is available yet for this article.
July 12, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/30002449/apoptosis-inhibitor-of-macrophage-and-diabetic-kidney-disease
#7
Timothy M E Davis, Kirsten E Peters, Richard Lipscombe
No abstract text is available yet for this article.
July 12, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29973649/the-methyltransferase-prmt6-attenuates-antiviral-innate-immunity-by-blocking-tbk1-irf3-signaling
#8
Hua Zhang, Chaofeng Han, Tianliang Li, Nan Li, Xuetao Cao
Protein arginine methyltransferases (PRMTs) play diverse biological roles and are specifically involved in immune cell development and inflammation. However, their role in antiviral innate immunity has not been elucidated. Viral infection triggers the TBK1-IRF3 signaling pathway to stimulate the production of type-I interferon, which mediates antiviral immunity. We performed a functional screen of the nine mammalian PRMTs for regulators of IFN-β expression and found that PRMT6 inhibits the antiviral innate immune response...
July 4, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29973648/the-chemokine-receptor-ccr7-is-a-promising-target-for-rheumatoid-arthritis-therapy
#9
Georgios L Moschovakis, Anja Bubke, Michaela Friedrichsen, Jasmin Ristenpart, Jaap Willem Back, Christine S Falk, Elisabeth Kremmer, Reinhold Förster
The chemokine receptor CCR7 and its ligands CCL19 and CCL21 guide the homing and positioning of dendritic and T cells in lymphoid organs, thereby contributing to several aspects of adaptive immunity and immune tolerance. In the present study, we investigated the role of CCR7 in the pathogenesis of collagen-induced arthritis (CIA). By using a novel anti-human CCR7 antibody and humanized CCR7 mice, we evaluated CCR7 as a target in this autoimmune model of rheumatoid arthritis (RA). Ccr7-deficient mice were completely resistant to CIA and presented severely impaired antibody responses to collagen II (CII)...
July 4, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29955175/an-altered-cd8-t-cell-epitope-of-insulin-prevents-type-1-diabetes-in-humanized-nod-mice
#10
Mengjun Zhang, Shufeng Wang, Binbin Guo, Gang Meng, Chi Shu, Wenli Mai, Qian Zheng, Xiaoling Chen, Yuzhang Wu, Li Wang
Autoreactive CD8+ T cells, which play an indispensable role in β cell destruction, represent an emerging target for the prevention of type 1 diabetes (T1D). Altered peptide ligands (APLs) can efficiently induce antigen-specific T cells anergy, apoptosis or shifts in the immune response. Here, we found that HLA-A*0201-restricted CD8+ T cell responses against a primary β-cell autoantigen insulin epitope InsB15-14 were present in both NOD.β2mnull .HHD NOD mice and T1D patients. We generated several APL candidates for InsB15 -14 by residue substitution at the p6 position...
June 28, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29456253/delicate-regulation-of-the-cgas-mita-mediated-innate-immune-response
#11
REVIEW
Wei-Wei Luo, Hong-Bing Shu
Although it has long been demonstrated that cytosolic DNA is a potent immune stimulant, it is only in recent years that the molecular mechanisms of DNA-stimulated innate immune responses have emerged. Studies have established critical roles for the DNA sensor cyclic GMP-AMP synthase (cGAS) and the adapter protein MITA/STING in the innate immune response to cytosolic DNA or DNA viruses. Although the regulation of cGAS-MITA/STING-mediated signaling remains to be fully investigated, understanding the processes involved may help to explain the mechanisms of innate immune signaling events and perhaps autoinflammatory diseases and to provide potential therapeutic targets for drug intervention...
July 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29375128/epigenetic-regulation-in-b-cell-maturation-and-its-dysregulation-in-autoimmunity
#12
REVIEW
Haijing Wu, Yaxiong Deng, Yu Feng, Di Long, Kongyang Ma, Xiaohui Wang, Ming Zhao, Liwei Lu, Qianjin Lu
B cells have a critical role in the initiation and acceleration of autoimmune diseases, especially those mediated by autoantibodies. In the peripheral lymphoid system, mature B cells are activated by self or/and foreign antigens and signals from helper T cells for differentiating into either memory B cells or antibody-producing plasma cells. Accumulating evidence has shown that epigenetic regulations modulate somatic hypermutation and class switch DNA recombination during B-cell activation and differentiation...
July 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29276217/roles-of-estrogens-on-myeloid-derived-suppressor-cells-in-cancer-and-autoimmune-diseases
#13
Jing Ren, Yayi Hou, Tingting Wang
No abstract text is available yet for this article.
July 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29921968/pdcd5-regulates-inkt-cell-terminal-maturation-and-inkt1-fate-decision
#14
Ke Wang, Xinwei Zhang, Yifan Wang, Gaowen Jin, Mingyang Li, Shusong Zhang, Jie Hao, Rong Jin, Xiaojun Huang, Hounan Wu, Jun Zhang, Yingyu Chen, Qing Ge
Invariant natural killer T1 (iNKT1) cells are characterized by the preferential expression of T-box transcription factor T-bet (encoded by Tbx21) and the production of cytokine IFN-γ, but the relationship between the developmental process and iNKT1 lineage diversification in the thymus remains elusive. We report in the present study a crucial role of programmed cell death 5 (PDCD5) in iNKT cell terminal maturation and iNKT1 fate determination. Mice with T cell-specific deletion of PDCD5 had decreased numbers of thymic and peripheral iNKT cells with a predominantly immature phenotype and defects in response to α-galactosylceramide...
June 19, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29921967/il-1-%C3%AE-genesis-the-art-of-regulating-the-regulator
#15
Priya Gupta, Manoj K Barthwal
No abstract text is available yet for this article.
June 19, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29921966/different-domains-of-%C3%AE-2-glycoprotein-i-play-a-role-in-autoimmune-pathogenesis
#16
Maurizio Sorice, Roberta Misasi
No abstract text is available yet for this article.
June 19, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29921965/interleukin-22-from-bench-to-bedside-a-promising-drug-for-epithelial-repair
#17
EDITORIAL
Bin Gao, Xiaogang Xiang
No abstract text is available yet for this article.
June 19, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29907883/b-cell-development-is-critically-dependent-on-nfatc1-activity
#18
Sabrina Giampaolo, Gabriela Wójcik, Stefan Klein-Hessling, Edgar Serfling, Amiya K Patra
B cell development in bone marrow is a precisely regulated complex process. Through successive stages of differentiation, which are regulated by a multitude of signaling pathways and an array of lineage-specific transcription factors, the common lymphoid progenitors ultimately give rise to mature B cells. Similar to early thymocyte development in the thymus, early B cell development in bone marrow is critically dependent on IL-7 signaling. During this IL-7-dependent stage of differentiation, several transcription factors, such as E2A, EBF1, and Pax5, among others, play indispensable roles in B lineage specification and maintenance...
June 15, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29907882/relevance-of-placental-type-i-interferon-beta-regulation-for-pregnancy-success
#19
Ja-Young Kwon, Paulomi Aldo, Yuan You, Jiahui Ding, Karen Racicot, Xiaoyan Dong, John Murphy, Guy Glukshtad, Michelle Silasi, Jian Peng, Li Wen, Vikki M Abrahams, Roberto Romero, Gil Mor
Pregnancy is a unique immunologic and microbial condition that requires an adequate level of awareness to provide a fast and protective response against pathogens as well as to maintain a state of tolerance to paternal antigens. Dysregulation of inflammatory pathways in the placenta triggered by pathogens is one of the main factors responsible for pregnancy complications. Type I IFNs are key molecules modulating immune responses at the level of the placenta and are crucial for protection of the pregnancy via their antiviral and immune modulatory properties...
June 15, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29907881/cortisol-facilitates-the-immune-escape-of-human-acute-myeloid-leukemia-cells-by-inducing-latrophilin-1-expression
#20
Svetlana S Sakhnevych, Inna M Yasinska, Alison M Bratt, Ouafa Benlaouer, Isabel Gonçalves Silva, Rohanah Hussain, Giuliano Siligardi, Walter Fiedler, Jasmin Wellbrock, Bernhard F Gibbs, Yuri A Ushkaryov, Vadim V Sumbayev
No abstract text is available yet for this article.
June 15, 2018: Cellular & Molecular Immunology
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