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Cellular & Molecular Immunology

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https://www.readbyqxmd.com/read/28713165/fatty-is-not-that-bad-feeding-short-chain-fatty-acids-to-restrain-autoimmunity
#1
Arianna Brevi, Matteo Bellone
No abstract text is available yet for this article.
July 17, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28713164/human-immunodeficiency-virus-type-1-induces-a-regulatory-b-cell-like-phenotype-in-vitro
#2
Jacobo Lopez-Abente, Adrián Prieto-Sanchez, Maria-Ángeles Muñoz-Fernandez, Rafael Correa-Rocha, Marjorie Pion
Individuals infected with human immunodeficiency virus type-1 (HIV-1) usually show a general dysregulation and hyper-activation of the immune system. A direct influence of HIV-1 particles on B-cell phenotypes and functions has been previously described. However, the consequences of B-cell dysregulation are still poorly understood. We evaluated the phenotypic changes in primary B cells after direct contact with HIV-1 particles in comparison with different types of stimuli. The functionality of treated B cells was challenged in co-culture experiments with autologous CD4+ and CD8+ T cells...
July 17, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28713163/microbiota-or-short-chain-fatty-acids-which-regulates-diabetes
#3
Chang H Kim
No abstract text is available yet for this article.
July 17, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28690333/characterization-and-biological-significance-of-il-23-induced-neutrophil-polarization
#4
Yang Li, Linnan Zhu, Zhulang Chu, Tao Yang, Hai-Xi Sun, Fan Yang, Wei Wang, Yuzhu Hou, Peng Wang, Qingjie Zhao, Yaling Tao, Lianfeng Zhang, Xiaodong Zhang, Yong Zhao
Neutrophils are heterogeneous with distinct subsets, and can switch phenotypes to exert regulatory functions on immunity. We herein demonstrate that IL-23-treated neutrophils selectively produce IL-17A, IL-17F and IL-22, and display a distinct gene expression profile in contrast to resting and lipopolysaccharide-treated neutrophils. IL-17(+) neutrophils are present in the colons of mice with dextran sulfate sodium-induced colitis. Adoptive transfer of IL-23-treated neutrophils significantly promotes pathogenesis in this model...
July 10, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28690332/caspases-control-antiviral-innate-immunity
#5
REVIEW
Huihui Chen, Xiaohan Ning, Zhengfan Jiang
Caspases are a family of cysteine proteases whose functions have been scrutinized intensively in recent years. Beyond their established roles in programmed cell death and inflammatory response, some caspases are also fundamental players in antiviral immunity by fine-tuning the levels of antiviral signaling adapters and cytokines, such as type I interferons, which serves as a major, sophisticated weapon against viruses. Viral infections can result in inflammasome activation and the initiation of cell death, including apoptosis and pyroptosis, and multiple caspases are significantly involved in these processes...
July 10, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28690331/diet-as-a-strategy-for-type-1-diabetes-prevention
#6
Flavia Prodam, Annalisa Chiocchetti, Umberto Dianzani
No abstract text is available yet for this article.
July 10, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28690330/irf1-and-batf-transcription-factors-that-set-the-epigenetic-landscape-for-tr1-cell-differentiation
#7
Katarina Stanko, Birgit Sawitzki
No abstract text is available yet for this article.
July 10, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28690329/macrophage-s-little-helper-vitamin-a-directs-alternatively-activated-monocyte-derived-macrophages-to-tissue-resident-macrophages
#8
Dirk Schlüter, Florian H Heidel
No abstract text is available yet for this article.
July 10, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28690328/il-33-a-jack-of-all-trades-in-the-orchestration-of-respiratory-antibacterial-immunity
#9
Julia D Boehme, Dunja Bruder
No abstract text is available yet for this article.
July 10, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28690327/long-noncoding-rna-lnckdm2b-a-critical-player-in-the-maintenance-of-group-3-innate-lymphoid-cells
#10
Can-Jie Guo, Weici Zhang, M Eric Gershwin
No abstract text is available yet for this article.
July 10, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28690326/shp-1-ptpn6-keeps-the-inflammation-at-bay-limiting-il-1%C3%AE-mediated-neutrophilic-dermatoses-by-preventing-syk-kinase-activation
#11
Ren-In You, Ching-Liang Chu
No abstract text is available yet for this article.
July 10, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28690325/dietary-therapy-may-be-sufficient-for-type-1-diabetes-treatment
#12
Shuoyang Liu, Xin Chen
No abstract text is available yet for this article.
July 10, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28690324/proteasome-inhibition-suppresses-th17-cell-generation-and-ameliorates-autoimmune-development-in-experimental-sj%C3%A3-gren-s-syndrome
#13
Fan Xiao, Xiang Lin, Jie Tian, Xiaohui Wang, Qian Chen, Ke Rui, Jie Ma, Shengjun Wang, Qingwen Wang, Xiaoqi Wang, Dongzhou Liu, Lingyun Sun, Liwei Lu
Immunoproteasome activation in immune cells is involved in the modulation of immune responses. Increasing evidence indicates that proteasome inhibitors show beneficial effects in treating autoimmune diseases, but it remains unclear whether proteasome inhibition is an effective approach for suppressing autoimmune development in Sjögren's syndrome (SS). Our previous work has demonstrated a critical role for Th17 cells in the development of experimental SS (ESS) in mice. In this study, we detected high levels of low-molecular-weight protein 7 (LMP7), a key subunit of the immunoproteasome, in Th17 cells from ESS mice...
July 10, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28690323/mechanisms-of-sterile-inflammation-in-acetaminophen-hepatotoxicity
#14
Hartmut Jaeschke
No abstract text is available yet for this article.
July 10, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28603280/dust-mite-allergen-specific-immunotherapy-increases-il4-dna-methylation-and-induces-der-p-specific-t-cell-tolerance-in-children-with-allergic-asthma
#15
Chuang-Ming Wang, Chia-Bin Chang, Michael Wy Chan, Zhi-Hong Wen, Shu-Fen Wu
Allergen-specific immunotherapy (allergen-SIT) is a highly effective treatment for children with allergic asthma (AA), an immune-mediated chronic disease leading to bronchial muscle hypertrophy and airway obstruction in response to specific allergens. T helper cells and secreted cytokines play important roles in the pathogenesis of asthma, and epigenetic modulation controls genes important for T cell development and cytokine expression. This study evaluated T helper cell-secreted cytokines and DNA methylation patterns in children treated with Dermatophagoides pteronyssinus (Der p) allergen-SIT...
June 26, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28626239/irfs-as-competing-pioneers-in-t-cell-differentiation
#16
Andrea Kröger
No abstract text is available yet for this article.
June 19, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28626238/irf1-and-batf-key-drivers-of-type-1-regulatory-t-cell-differentiation
#17
Sophia Giang, Antonio La Cava
No abstract text is available yet for this article.
June 19, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28626237/cd4-t-cells-memorize-obesity-and-promote-weight-regain
#18
Jianghuan Zou, Beibei Lai, Mingzhu Zheng, Qin Chen, Shujun Jiang, Anying Song, Zan Huang, Peiliang Shi, Xin Tu, Di Wang, Linrong Lu, Zhaoyu Lin, Xiang Gao
Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown. In this study, we report that immune cells, especially CD4+ T cells, mediate the 'memory' of previous obese status. In a weight gain-loss-regain model, we found that C57BL/6J mice with an obesity history showed a much faster rate of body weight regain. This obesity memory could last for at least 2 months after previously obese mice were kept at the same body weight as non-obese mice. Surprisingly, such obesity memory was abrogated by dexamethasone treatment, whereas immunodeficient Rag1(-/-) and H2A(-/-) mice failed to establish such memory...
June 19, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28626236/themis2-setting-the-threshold-for-b-cell-selection
#19
Mukta Deobagkar-Lele, Consuelo Anzilotti, Richard J Cornall
No abstract text is available yet for this article.
June 19, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28626235/human-%C3%AE-%C3%AE-t-cells-rapid-stable-and-clonally-reactive
#20
Avi-Hai Hovav
No abstract text is available yet for this article.
June 19, 2017: Cellular & Molecular Immunology
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