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Cellular & Molecular Immunology

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https://www.readbyqxmd.com/read/29429998/zdhhc11-modulates-innate-immune-response-to-dna-virus-by-mediating-mita-irf3-association
#1
Ying Liu, Qian Zhou, Li Zhong, Heng Lin, Ming-Ming Hu, Yan Zhou, Hong-Bing Shu, Shu Li
MITA is a central adaptor in innate immune responses to DNA viruses. The mechanisms responsible for recruitment of downstream kinase TBK1 and the transcription factor IRF3 to MITA remains enigmatic. Here we identified ZDHHC11, a member of DHHC palmitoyl transferase family, as a positive regulator of DNA virus-triggered signaling. Overexpression of ZDHHC11 activated the IFN-β promoter, while ZDHHC11-deficiency specifically impaired DNA virus HSV-1-induced transcription of downstream antiviral genes. Zdhhc11-/- mice exhibited lower serum cytokine levels and higher lethality after HSV-1 infection...
February 12, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29429997/de-novo-vs-inherited-copy-number-variations-in-multiple-sclerosis-susceptibility
#2
Kalthoum Tizaoui
No abstract text is available yet for this article.
February 12, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29429996/application-of-light-sheet-microscopy-for-qualitative-and-quantitative-analysis-of-bronchus-associated-lymphoid-tissue-in-mice
#3
David Twapokera Mzinza, Henrike Fleige, Kristin Laarmann, Stefanie Willenzon, Jasmin Ristenpart, Julia Spanier, Gerd Sutter, Ulrich Kalinke, Peter Valentin-Weigand, Reinhold Förster
Bronchus-associated lymphoid tissue (BALT) develops at unpredictable locations around lung bronchi following pulmonary inflammation. The formation and composition of BALT have primarily been investigated by immunohistology that, due to the size of the invested organ, is usually restricted to a limited number of histological sections. To assess the entire BALT of the lung, other approaches are urgently needed. Here, we introduce a novel light sheet microscopy-based approach for assessing lymphoid tissue in the lung...
February 12, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29429995/mir-125b-5p-and-mir-99a-5p-downregulate-human-%C3%AE-%C3%AE-t-cell-activation-and-cytotoxicity
#4
Yuli Zhu, Siya Zhang, Zinan Li, Huaishan Wang, Zhen Li, Yu Hu, Hui Chen, Xuan Zhang, Lianxian Cui, Jianmin Zhang, Wei He
As an important component of innate immunity, human circulating γδ T cells function in rapid responses to infections and tumorigenesis. MicroRNAs (miRNAs) play a critical regulatory role in multiple biological processes and diseases. Therefore, how the functions of circulating human γδ T cells are regulated by miRNAs merits investigation. In this study, we profiled the miRNA expression patterns in human peripheral γδ T cells from 21 healthy donors and identified 14 miRNAs that were differentially expressed between peripheral αβ T cells and γδ T cells...
February 12, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29429994/flip-the-switch-btg2-prmt1-protein-complexes-antagonize-pre-b-cell-proliferation-to-promote-b-cell-development
#5
Glendon S Wu, Craig H Bassing
No abstract text is available yet for this article.
February 12, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29429993/the-non-canonical-wnt-pathway-leads-to-aged-dendritic-cell-differentiation
#6
Haibo Zhou, Li Wu
No abstract text is available yet for this article.
February 12, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29400708/predictive-immune-biomarkers-an-unattainable-chimera
#7
Anna Maria Trotta, Roberto Pacelli, Stefania Scala
No abstract text is available yet for this article.
February 5, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29400707/il-33-induces-immunosuppressive-neutrophils-via-a-type-2-innate-lymphoid-cell-il-13-stat6-axis-and-protects-the-liver-against-injury-in-lcmv-infection-induced-viral-hepatitis
#8
Yuejin Liang, Panpan Yi, Denley Ming Kee Yuan, Zuliang Jie, Zakari Kwota, Lynn Soong, Yingzi Cong, Jiaren Sun
Viral hepatitis is still a public health problem affecting several million people around the world. Neutrophils are polymorphonuclear cells that have a critical role in antibacterial infection. However, the role of neutrophils in viral infection is not fully understood. By using a mouse model of lymphocytic choriomeningitis virus infection-induced viral hepatitis, we observed increased neutrophil recruitment in the liver accompanied by enhanced CD8+ T-cell responses. Liver neutrophils expressed high levels of immunomodulatory cytokines, such as C-X-C chemokine ligand 2, arginase-1, inducible nitric oxide synthase and interleukin (IL)-10, demonstrating immunosuppressive properties...
February 5, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29400706/profiling-the-pattern-of-the-human-t-cell-receptor-%C3%AE-%C3%AE-complementary-determinant-region-3-repertoire-in-patients-with-lung-carcinoma-via-high-throughput-sequencing-analysis
#9
Hui Chen, Mingjin Zou, Da Teng, Yu Hu, Jianmin Zhang, Wei He
γδ T cells function as sentinels in early host responses to infections and malignancies. Specifically, γδ T cells recognize tumor-associated stress antigens via T-cell receptor (TCR) γδ and play important roles in the antitumor immune response. In this study, we characterized the pattern of the human TCR γδ complementary determinant region 3 (CDR3) repertoire in patients with lung carcinoma (LC) via high-throughput sequencing. The results showed that the diversity of CDR3δ was significantly reduced, and that of CDR3γ was unchanged in LC patients compared with healthy individuals; in addition, LC patients shared significantly more CDR3δ sequences with each other than healthy individuals...
February 5, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29400705/taok1-negatively-regulates-il-17-mediated-signaling-and-inflammation
#10
Zhaoru Zhang, Zhen Tang, Xianwei Ma, Kai Sun, Liping Fan, Jie Fang, Jianping Pan, Xiaojian Wang, Huazhang An, Jun Zhou
Interleukin 17 (IL-17) is an important cytokine that can induce tissue inflammation and is involved in the pathogenesis of numerous autoimmune diseases. However, the regulation of its signaling transduction has not been well described. In this study, we report that thousand and one kinase 1 (TAOK1) functions as a negative regulator of IL-17-mediated signal transduction and inflammation. TAOK1 knockdown promotes IL-17-induced cytokine and chemokine expression and the activation of mitogen-activated protein kinases and nuclear factor-κB...
February 5, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29400704/functions-of-nkg2d-in-cd8-t-cells-an-opportunity-for-immunotherapy
#11
REVIEW
Kushal Prajapati, Cynthia Perez, Lourdes Beatriz Plaza Rojas, Brianna Burke, Jose A Guevara-Patino
Natural killer group 2 member D (NKG2D) is a type II transmembrane receptor. NKG2D is present on NK cells in both mice and humans, whereas it is constitutively expressed on CD8+ T cells in humans but only expressed upon T-cell activation in mice. NKG2D is a promiscuous receptor that recognizes stress-induced surface ligands. In NK cells, NKG2D signaling is sufficient to unleash the killing response; in CD8+ T cells, this requires concurrent activation of the T-cell receptor (TCR). In this case, the function of NKG2D is to authenticate the recognition of a stressed target and enhance TCR signaling...
February 5, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29400703/comprehensive-review-of-autoantibodies-in-patients-with-hyper-igm-syndrome
#12
Mohamed-Ridha Barbouche, Qubo Chen, Marco Carbone, Imen Ben-Mustapha, Zakera Shums, Mehdi Trifa, Federica Malinverno, Francesca Bernuzzi, Haiyan Zhang, Nourhen Agrebi, Gary L Norman, Christopher Chang, M Eric Gershwin, Pietro Invernizzi
Hyper-immunoglobulin M syndrome is an X-linked primary immunodeficiency disease caused by mutations in the CD40 ligand gene. The CD40 ligand has been recently highlighted as playing a key role in the pathogenesis of primary biliary cholangitis. In the present study, we assessed an extensive set of serum autoantibodies in a series of well-defined patients with hyper-immunoglobulin M syndrome. Serum, liver-related and liver-not-related autoantibodies IgG, IgM and IgA were tested by ELISA and standard indirect immunofluorescence in HEp-2 cells in 13 Tunisian patients (8 males and 5 females, aged 1-12 years) with hyper-immunoglobulin M syndrome during 1995-2012 and, as controls, 21 age- and gender-matched blood donors...
February 5, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29375133/tumor-necrosis-factor-the-key-to-hepatitis-b-viral-clearance
#13
I-Tsu Chyuan, Ping-Ning Hsu
No abstract text is available yet for this article.
January 29, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29375132/stimulation-of-tnf-receptor-type-2-expands-regulatory-t-cells-and-ameliorates-established-collagen-induced-arthritis-in-mice
#14
Vanessa Lamontain, Tobias Schmid, Dorothea Weber-Steffens, David Zeller, Zsuzsa Jenei-Lanzl, Harald Wajant, Rainer H Straub, Daniela N Männel
Tumor necrosis factor (TNF) and its receptors TNF receptor type 1 (TNFR1) and type 2 (TNFR2) have a central role in chronic inflammatory diseases. While TNFR1 mainly confers inflammation, activation of TNFR2 elicits not only pro-inflammatory but also anti-inflammatory effects. In this study, we wanted to investigate the anti-inflammatory therapeutic potential of selective activation of TNFR2 in mice with established collagen-induced arthritis. Mice with established arthritis induced by immunization with bovine collagen type II were treated with six injections of the TNFR2-specific agonist TNCscTNF80, given every second day...
January 29, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29375131/a-modified-hla-a-0201-restricted-ctl-epitope-from-human-oncoprotein-hpebp4-induces-more-efficient-antitumor-responses
#15
Weihong Sun, Junyi Shi, Jian Wu, Junchu Zhang, Huabiao Chen, Yuanyuan Li, Shuxun Liu, Yanfeng Wu, Zhigang Tian, Xuetao Cao, Nan Li
We previously identified human phosphatidylethanolamine-binding protein 4 (hPEBP4) as an antiapoptotic protein with increased expression levels in breast, ovarian and prostate cancer cells, but low expression levels in normal tissues, which makes hPEBP4 an attractive target for immunotherapy. Here, we developed hPEBP4-derived immunogenic peptides for inducing antigen-specific cytotoxic T lymphocytes (CTLs) targeting breast cancer. A panel of hPEBP4-derived peptides predicted by peptide-MHC-binding algorithms was evaluated to characterize their HLA-A2...
January 29, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29375130/cd8-cd28-t-cells-not-only-age-related-cells-but-a-subset-of-regulatory-t-cells
#16
Xiaoyong Chen, Qiuli Liu, Andy Peng Xiang
No abstract text is available yet for this article.
January 29, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29375129/immunological-roulette-luck-or-something-more-considering-the-connections-between-host-and-environment-in-tb
#17
John E Pearl, Mrinal Das, Andrea M Cooper
Accurate prediction of which patient will progress from a sub-clinical Mycobacterium tuberculosis infection to active tuberculosis represents an elusive, yet critical, clinical research objective. From the individual perspective, progression can be considered to be the product of a series of unfortunate events or even a run of bad luck. Here, we identify the subtle physiological relationships that can influence the odds of progression to active TB and how this progression may reflect directed dysbiosis in a number of interrelated systems...
January 29, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29375128/epigenetic-regulation-in-b-cell-maturation-and-its-dysregulation-in-autoimmunity
#18
REVIEW
Haijing Wu, Yaxiong Deng, Yu Feng, Di Long, Kongyang Ma, Xiaohui Wang, Ming Zhao, Liwei Lu, Qianjin Lu
B cells have a critical role in the initiation and acceleration of autoimmune diseases, especially those mediated by autoantibodies. In the peripheral lymphoid system, mature B cells are activated by self or/and foreign antigens and signals from helper T cells for differentiating into either memory B cells or antibody-producing plasma cells. Accumulating evidence has shown that epigenetic regulations modulate somatic hypermutation and class switch DNA recombination during B-cell activation and differentiation...
January 29, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29375127/proteomic-analysis-reveals-distinctive-protein-profiles-involved-in-cd8-t-cell-mediated-murine-autoimmune-cholangitis
#19
Weici Zhang, Ren Zhang, Jun Zhang, Ying Sun, Patrick Sc Leung, Guo-Xiang Yang, Zongwen Shuai, William M Ridgway, M Eric Gershwin
Autoimmune cholangitis arises from abnormal innate and adaptive immune responses in the liver, and T cells are critical drivers in this process. However, little is known about the regulation of their functional behavior during disease development. We previously reported that mice with T cell-restricted expression of a dominant negative form of transforming growth factor beta receptor type II (dnTGFβRII) spontaneously develop an autoimmune cholangitis that resembles human primary biliary cholangitis (PBC). Adoptive transfer of CD8+ but not CD4+ T cells into Rag1-/- mice reproduced the disease, demonstrating a critical role for CD8+ T cells in PBC pathogenesis...
January 29, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29375126/chemokines-in-homeostasis-and-diseases
#20
REVIEW
Keqiang Chen, Zhiyao Bao, Peng Tang, Wanghua Gong, Teizo Yoshimura, Ji Ming Wang
For the past twenty years, chemokines have emerged as a family of critical mediators of cell migration during immune surveillance, development, inflammation and cancer progression. Chemokines bind to seven transmembrane G protein-coupled receptors (GPCRs) that are expressed by a wide variety of cell types and cause conformational changes in trimeric G proteins that trigger the intracellular signaling pathways necessary for cell movement and activation. Although chemokines have evolved to benefit the host, inappropriate regulation or utilization of these small proteins may contribute to or even cause diseases...
January 29, 2018: Cellular & Molecular Immunology
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