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Cellular & Molecular Immunology

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https://www.readbyqxmd.com/read/28626239/irfs-as-competing-pioneers-in-t-cell-differentiation
#1
Andrea Kröger
No abstract text is available yet for this article.
June 19, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28626238/irf1-and-batf-key-drivers-of-type-1-regulatory-t-cell-differentiation
#2
Sophia Giang, Antonio La Cava
No abstract text is available yet for this article.
June 19, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28626237/cd4-t-cells-memorize-obesity-and-promote-weight-regain
#3
Jianghuan Zou, Beibei Lai, Mingzhu Zheng, Qin Chen, Shujun Jiang, Anying Song, Zan Huang, Peiliang Shi, Xin Tu, Di Wang, Linrong Lu, Zhaoyu Lin, Xiang Gao
Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown. In this study, we report that immune cells, especially CD4+ T cells, mediate the 'memory' of previous obese status. In a weight gain-loss-regain model, we found that C57BL/6J mice with an obesity history showed a much faster rate of body weight regain. This obesity memory could last for at least 2 months after previously obese mice were kept at the same body weight as non-obese mice. Surprisingly, such obesity memory was abrogated by dexamethasone treatment, whereas immunodeficient Rag1(-/-) and H2A(-/-) mice failed to establish such memory...
June 19, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28626236/themis2-setting-the-threshold-for-b-cell-selection
#4
Mukta Deobagkar-Lele, Consuelo Anzilotti, Richard J Cornall
No abstract text is available yet for this article.
June 19, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28626235/human-%C3%AE-%C3%AE-t-cells-rapid-stable-and-clonally-reactive
#5
Avi-Hai Hovav
No abstract text is available yet for this article.
June 19, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28626234/b-cell-regulation-in-cancer-and-anti-tumor-immunity
#6
REVIEW
Anushruti Sarvaria, J Alejandro Madrigal, Aurore Saudemont
The balance between immune effector cells and immunosuppressive cells and how this regulates the tumor microenvironment has been well described. A significant contribution of immune regulatory cells, including regulatory T cells, to tumor progression has been widely reported. An emerging body of evidence has recently recognized a role for B cells in modulating the immune response to tumors and lymphoid malignancies. Regulatory B cells (Bregs) are a newly designated subset of B cells that have been shown to play a pivotal role in regulating immune responses involved in inflammation, autoimmunity and, more recently, cancer...
June 19, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28626233/themis-releases-the-brakes-on-tcr-signaling-during-thymocyte-selection-by-disabling-shp-1
#7
Laura Patrussi, Cosima T Baldari
No abstract text is available yet for this article.
June 19, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28626232/the-rip3-rip1-nf-%C3%AE%C2%BAb-signaling-axis-is-dispensable-for-necroptotic-cells-to-elicit-cross-priming-of-cd8-t-cells
#8
Junming Ren, Xian Jia, Yihao Zhao, Wenke Shi, Jiongcong Lu, Yingying Zhang, Jianfeng Wu, Bo Liang, Rui Wu, Guo Fu, Jiahuai Han
No abstract text is available yet for this article.
June 19, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28579615/type-3-innate-lymphoid-cell-derived-lymphotoxin-prevents-microbiota-dependent-inflammation
#9
Yuan Zhang, Tae-Jin Kim, Joanna A Wroblewska, Vera Tesic, Vaibhav Upadhyay, Ralph R Weichselbaum, Alexei V Tumanov, Hong Tang, Xiaohuan Guo, Haidong Tang, Yang-Xin Fu
Splenomegaly is a well-known phenomenon typically associated with inflammation. However, the underlying cause of this phenotype has not been well characterized. Furthermore, the splenomegaly phenotype seen in lymphotoxin (LT) signaling-deficient mice is characterized by increased numbers of splenocytes and splenic neutrophils. Splenomegaly, as well as the related phenotype of increased lymphocyte counts in non-lymphoid tissues, is thought to result from the absence of secondary lymphoid tissues in LT-deficient mice...
June 5, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28552905/harnessing-class-ii-histone-deacetylases-in-macrophages-to-combat-breast-cancer
#10
Hadar Reichman, Ariel Munitz
No abstract text is available yet for this article.
May 29, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28552904/crystal-structure-of-hla-b-5801-with-a-tw10-hiv-gag-epitope-reveals-a-novel-mode-of-peptide-presentation
#11
Xiaolong Li, Pedro A Lamothe, Bruce D Walker, Jia-Huai Wang
No abstract text is available yet for this article.
May 29, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28552903/themis-the-new-kid-on-the-block-for-t-cell-development
#12
Janyra A Espinoza, Evelyn L Jara, Alexis M Kalergis
No abstract text is available yet for this article.
May 29, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28529333/a-vestigial-pathway-for-sex-differences-in-immune-regulation
#13
Yun Liang, J Michelle Kahlenberg, Johann E Gudjonsson
No abstract text is available yet for this article.
May 22, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28504245/macrophage-derived-il-1%C3%AE-promotes-sterile-inflammation-in-a-mouse-model-of-acetaminophen-hepatotoxicity
#14
Chao Zhang, Jin Feng, Jun Du, Zhiyong Zhuo, Shuo Yang, Weihong Zhang, Weihong Wang, Shengyuan Zhang, Yoichiro Iwakura, Guangxun Meng, Yang-Xin Fu, Baidong Hou, Hong Tang
The metabolic intermediate of acetaminophen (APAP) can cause severe hepatocyte necrosis, which triggers aberrant immune activation of liver non-parenchymal cells (NPC). Overzealous hepatic inflammation determines the morbidity and mortality of APAP-induced liver injury (AILI). Interleukin-1 receptor (IL-1R) signaling has been shown to play a critical role in various inflammatory conditions, but its precise role and underlying mechanism in AILI remain debatable. Herein, we show that NLRP3 inflammasome activation of IL-1β is dispensable to AILI, whereas IL-1α, the other ligand of IL-1R1, accounts for hepatic injury by a lethal dose of APAP...
May 15, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28479602/a-new-vaccination-strategy-to-trigger-specific-cd4-t-cell-response-in-chronic-viral-infection
#15
Allan Randrup Thomsen
No abstract text is available yet for this article.
May 8, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28479601/b7-dc-pd-l2-costimulation-of-cd4-t-helper-1-response-via-rgmb
#16
Xinxin Nie, Wenni Chen, Ying Zhu, Baozhu Huang, Weiwei Yu, Zhanshuai Wu, Sizheng Guo, Yiping Zhu, Liqun Luo, Shengdian Wang, Lieping Chen
The role of B7-DC in T-cell responses remains controversial because both coinhibitory and costimulatory functions have been reported in various experimental systems in vitro and in vivo. In addition to interacting with the coinhibitory receptor PD-1, B7-DC has also been shown to bind repulsive guidance molecule b (RGMb). The functional consequences of the B7-DC/RGMb interaction, however, remain unclear. More than a decade ago, we reported that replacement of a murine B7-DC mutant lysine with serine (K113S) at positive 113 resulted in a loss of binding capacity to PD-1...
May 8, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28479600/a-crucial-role-of-the-pd-1h-coinhibitory-receptor-in-suppressing-experimental-asthma
#17
Huafeng Liu, Xin Li, Li Hu, Min Zhu, Bailin He, Liqun Luo, Lieping Chen
Programmed death one homolog (PD-1H) is a cell surface molecule of the B7/CD28 immune modulatory gene family. Although PD-1H has been shown to function as a coinhibitory receptor on T cells to limit naive T-cell activation and proliferation, its role in the regulation of the T-cell response to allergens is unknown. We report here that genetic ablation or blockade of PD-1H drastically promotes pulmonary inflammation with massive accumulation of eosinophils in a mouse model of experimental asthma, indicating a suppressive function of PD-1H in allergic inflammation...
May 8, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28458392/il-17-triggered-downregulation-of-mir-497-results-in-high-hif-1%C3%AE-expression-and-consequent-il-1%C3%AE-and-il-6-production-by-astrocytes-in-eae-mice
#18
Kai Shan, Rongrong Pang, Chenhui Zhao, Xiaomei Liu, Wenxing Gao, Jing Zhang, Dan Zhao, Yingwei Wang, Wen Qiu
Interleukin 17 (IL-17) is increasingly recognized as a key factor that contributes to the pathogenesis of multiple sclerosis (MS) and its experimental mouse autoimmune encephalomyelitis (EAE) model. However, the roles and regulatory mechanisms of IL-17-induced pro-inflammatory cytokine production in EAE mice remain largely unclear. In this study, the expression of IL-17, hypoxia inducible factor-1α (HIF-1α), IL-1β, IL-6 and microRNA-497 (miR-497), as well as their intrinsic associations, was investigated using EAE model mice and cultured astrocytes exposed to IL-17 in vitro...
May 1, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28435159/ifitm3-inhibits-virus-triggered-induction-of-type-i-interferon-by-mediating-autophagosome-dependent-degradation-of-irf3
#19
Li-Qun Jiang, Tian Xia, Yun-Hong Hu, Ming-Shun Sun, Shuang Yan, Cao-Qi Lei, Hong-Bing Shu, Ji-Hua Guo, Yu Liu
Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that can be induced by viral infection and interferons (IFNs). It inhibits the entry and replication of many viruses, which are independent of receptor usage but dependent on processes that occur in endosomes. In this study, we demonstrate that IFITM3 plays important roles in regulating the RNA-virus-triggered production of IFN-β in a negative-feedback manner. Overexpression of IFITM3 inhibited Sendai virus-triggered induction of IFN-β, whereas knockdown of IFITM3 had the opposite effect...
April 24, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28435158/a-balancing-act-between-ifitm3-and-irf3
#20
Temet M McMichael, Mahesh Chemudupati, Jacob S Yount
No abstract text is available yet for this article.
April 24, 2017: Cellular & Molecular Immunology
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