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Cellular & Molecular Immunology

Emma Rey-Jurado, Magdalena S Pizarro-Ortega, Alexis M Kalergis
No abstract text is available yet for this article.
November 7, 2018: Cellular & Molecular Immunology
Sundararajan Jayaraman
No abstract text is available yet for this article.
November 7, 2018: Cellular & Molecular Immunology
Iman Dalloul, Zeinab Dalloul, Sandrine Le Noir, François Boyer, Bernardo Reina-San-Martin, Jeanne Cook-Moreau, Michel Cogné
No abstract text is available yet for this article.
November 7, 2018: Cellular & Molecular Immunology
Maxi Heyner, Sarah Schreier, Andrea Kröger
During viral infections, cell death can be induced as a direct result of cytopathic virus replication in various cell types and tissues or as an immune response of the host to the infectious agent. This leads to an infiltration of inflammatory cells, causing subsequent tissue damage. The balance between effective elimination of the pathogen and prevention of fatal tissue damage is decisive for life. The host has developed various mechanisms to inhibit excessive immune responses.
November 7, 2018: Cellular & Molecular Immunology
Sarah J Dulson, Laurie E Harrington, Allan J Zajac
No abstract text is available yet for this article.
November 7, 2018: Cellular & Molecular Immunology
Árpád Furka
No abstract text is available yet for this article.
October 29, 2018: Cellular & Molecular Immunology
Huihuang Huang, Siyu Wang, Tianjun Jiang, Rong Fan, Zheng Zhang, Jinsong Mu, Ke Li, Yonggang Wang, Lei Jin, Fang Lin, Jie Xia, Lijian Sun, Biao Xu, Chengcheng Ji, Jing Chen, Juan Chang, Bo Tu, Bing Song, Chao Zhang, Fu-Sheng Wang, Ruonan Xu
Granulocyte colony-stimulating factor (GM-CSF), produced by CD4+ T cells, has recently been implicated in the pathogenesis of inflammatory diseases, such as multiple sclerosis and juvenile arthritis. However, the role of GM-CSF-producing CD4+ T cells in sepsis remains unknown. This study reports peripheral changes in GM-CSF-producing CD4+ T cells in septic patients and the possible underlying mechanism by which GM-CSF influences the outcome of sepsis. Forty-three septic patients, 20 SIRS patients, and 20 healthy controls were enrolled in this study and followed for 28 days to assess mortality...
October 16, 2018: Cellular & Molecular Immunology
Hend Boutouil, François Boyer, Jeanne Cook-Moreau, Michel Cogné, Sophie Péron
No abstract text is available yet for this article.
October 15, 2018: Cellular & Molecular Immunology
Nour Ghazzaui, Hussein Issaoui, François Boyer, Ophélie Alyssa Martin, Alexis Saintamand, Yves Denizot
No abstract text is available yet for this article.
October 10, 2018: Cellular & Molecular Immunology
Yuying Liu, Tianzhen Zhang, Yabo Zhou, Jiping Li, Xiaoyu Liang, Nannan Zhou, Jiadi Lv, Jing Xie, Feiran Cheng, Yiliang Fang, Yunfeng Gao, Ning Wang, Bo Huang
Different types of pores ubiquitously form in cell membranes, leading to various types of cell death that profoundly influence the fate of inflammation and the disease status. However, these pores have never truly been visualized to date. Atomic force microscopy (AFM), which is emerging as a powerful tool to analyze the mechanical properties of biomolecules and cells, is actually an excellent imaging platform that allows biological samples to be visualized by probing surface roughness at the level of atomic resolution...
October 3, 2018: Cellular & Molecular Immunology
Xiang Chen, Xingguang Liu, Yunkai Zhang, Wanwan Huai, Qingqing Zhou, Sheng Xu, Xi Chen, Nan Li, Xuetao Cao
Epigenetic modification, including histone modification, precisely controls target gene expression. The posttranscriptional regulation of the innate signaling-triggered production of inflammatory cytokines and type I interferons has been fully elucidated, whereas the roles of histone modification alteration and epigenetic modifiers in regulating inflammatory responses need to be further explored. Di/tri-methylation modifications of histone 3 lysine 79 (H3K79me2/3) have been shown to be associated with gene transcriptional activation...
October 1, 2018: Cellular & Molecular Immunology
Paola Kučan Brlić, Tihana Lenac Roviš, Guy Cinamon, Pini Tsukerman, Ofer Mandelboim, Stipan Jonjić
Poliovirus receptor (PVR, CD155) has recently been gaining scientific interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions. In contrast to healthy tissues, PVR is expressed at high levels in several human malignancies and seems to have protumorigenic and therapeutically attractive properties that are currently being investigated in the field of recombinant oncolytic virotherapy. More intriguingly, PVR participates in a considerable number of immunoregulatory functions through its interactions with activating and inhibitory immune cell receptors...
October 1, 2018: Cellular & Molecular Immunology
Elias Abou-Samra, Zachary Hickey, Oscar A Aguilar, Michal Scur, Ahmad Bakur Mahmoud, Sergey Pyatibrat, Megan M Tu, Jeffrey Francispillai, Arthur Mortha, James R Carlyle, Mir Munir A Rahim, Andrew P Makrigiannis
Helper-type innate lymphoid cells (ILC) play an important role in intestinal homeostasis. Members of the NKR-P1 gene family are expressed in various innate immune cells, including natural killer (NK) cells, and their cognate Clr ligand family members are expressed in various specialized tissues, including the intestinal epithelium, where they may play an important role in mucosal-associated innate immune responses. In this study, we show that the inhibitory NKR-P1B receptor, but not the Ly49 receptor, is expressed in gut-resident NK cells, ILC, and a subset of γδT cells in a tissue-specific manner...
October 1, 2018: Cellular & Molecular Immunology
Ning Liu, Yuxue Jiang, Jintong Chen, He Nan, Yinghua Zhao, Xiao Chu, Alison Wang, Dongjiao Wang, Tianxue Qin, Sujun Gao, Qing Yi, Ying Yue, Siqing Wang
Dendritic cell (DC) tumor vaccines exert their antitumor effects through the induction of effector T cells. We recently identified Tc9 cells as a new potent antitumor effector T cell subset. However, approaches to direct DCs to preferably prime antitumor Tc9 cells should be further exploited. Here, we demonstrate that the addition of interleukin (IL)-33 potently promotes the induction of Tc9 cells by DCs in vitro and in vivo. IL-33 treatment also drives the cytotoxic activities of DC-induced Tc9 cells. Notably, IL-33 treatment enhances cell survival and proliferation of DC-primed CD8+ T cells...
October 1, 2018: Cellular & Molecular Immunology
Zhenlu Chong, Chunjing Bao, Jia He, Tianxiao Chen, Lijia Zhong, Gaopeng Li, Huanle Li, Lutong Fang, Yinjing Song, Guoxiang Fu, Xuyan Yang, Lihua Lai, Yang Liu, Qingqing Wang
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, and the pathogenesis of SLE has not been fully elucidated. The E3 ubiquitin ligase FBXW7 has been well characterized in cancer as a tumor suppressor that can promote the ubiquitination and subsequent degradation of various oncoproteins; however, the potential role of FBXW7 in autoimmune diseases is unclear. In the present study, we identified that FBXW7 is a crucial exacerbating factor for SLE development and progression in a mouse model induced by 2, 6, 10, 14-tetramethylpentadecane (TMPD)...
October 1, 2018: Cellular & Molecular Immunology
Sophie M Poznanski, Ali A Ashkar
No abstract text is available yet for this article.
October 1, 2018: Cellular & Molecular Immunology
Bhagawat C Subramanian
No abstract text is available yet for this article.
October 1, 2018: Cellular & Molecular Immunology
Mohamad Omar Ashi, Nivine Srour, Jean-Marie Lambert, Anne Marchalot, Ophélie Martin, Sandrine Le Noir, Eric Pinaud, Maria Victoria Ayala, Christophe Sirac, Jérôme Saulière, Jérôme Moreaux, Michel Cogné, Laurent Delpy
The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin (Ig) pre-mRNAs. We recently demonstrated that aberrant Ig chains lacking variable (V) domains can be produced after nonsense-associated altered splicing (NAS) events. Remarkably, the expression of these truncated Ig polypeptides heightens endoplasmic reticulum stress and shortens plasma cell (PC) lifespan. Many questions remain regarding the molecular mechanisms underlying this new truncated Ig exclusion (TIE-) checkpoint and its restriction to the ultimate stage of B-cell differentiation...
August 20, 2018: Cellular & Molecular Immunology
Wen-Yu Chen, Sheng-Yang Wu, Ta-Chun Lin, Shuei-Liong Lin, Betty A Wu-Hsieh
We generated a human dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) transgenic mouse in which renal tubular epithelial cells expressed DC-SIGN. The transgenic mice were infected with Candida albicans intravenously to study how DC-SIGN expression affected the pathogenesis of systemic candidiasis. We discovered that, while C. albicans infection induced renal fibrosis in both transgenic and littermate control mice, the transgenic mice had significantly lower levels of Acta2, Col1a2, Col3a1, and Col4a1 mRNA transcripts compared to the controls...
August 20, 2018: Cellular & Molecular Immunology
Issaoui Hussein, Ghazzaui Nour, Boyer François, Denizot Yves, Saintamand Alexis
No abstract text is available yet for this article.
August 20, 2018: Cellular & Molecular Immunology
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