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Cellular & Molecular Immunology

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https://www.readbyqxmd.com/read/29225341/humoral-immunity-the-underestimated-player-in-hepatitis-b
#1
Shuye Zhang, Juanjuan Zhao, Zheng Zhang
No abstract text is available yet for this article.
December 11, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29225340/genetic-and-experimental-evidence-for-the-involvement-of-the-cd6-lymphocyte-receptor-in-psoriasis
#2
Marta Consuegra-Fernández, Marc Julià, Mario Martínez-Florensa, Fernando Aranda, Cristina Català, Noelia Armiger-Borràs, María-Teresa Arias, Francisca Santiago, Antonio Guilabert, Anna Esteve, Carlos Muñoz, Carlos Ferrándiz, José-Manuel Carrascosa, Edurne Pedrosa, Jorge Romaní, Mercè Alsina, José-Manuel Mascaró-Galy, Francisco Lozano
Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for the treatment of certain autoimmune disorders, including psoriasis. Here, we present novel evidence in mice and humans for a direct involvement of CD6 in psoriasis pathophysiology. First, an attenuated form of imiquimod-induced psoriasis-like skin inflammation was demonstrated in CD6-deficient mice, as deduced from lower epidermal thickness and local reduced production of pro-inflammatory cytokines, namely, interleukin-17A...
December 11, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29200194/recent-advances-in-regulatory-t-cells-induced-by-b-cells
#3
Chien-Hui Chien, Bor-Luen Chiang
No abstract text is available yet for this article.
December 4, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29200193/immunogenetic-factors-driving-formation-of-ultralong-vh-cdr3-in-bos-taurus-antibodies
#4
Thaddeus C Deiss, Melissa Vadnais, Feng Wang, Patricia L Chen, Ali Torkamani, Waithaka Mwangi, Marie-Paule Lefranc, Michael F Criscitiello, Vaughn V Smider
The antibody repertoire of Bos taurus is characterized by a subset of variable heavy (VH) chain regions with ultralong third complementarity determining regions (CDR3) which, compared to other species, can provide a potent response to challenging antigens like HIV env. These unusual CDR3 can range to over seventy highly diverse amino acids in length and form unique β-ribbon 'stalk' and disulfide bonded 'knob' structures, far from the typical antigen binding site. The genetic components and processes for forming these unusual cattle antibody VH CDR3 are not well understood...
December 4, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29176750/chemoattractants-and-cytokines-in-primary-ciliary-dyskinesia-and-cystic-fibrosis-key-players-in-chronic-respiratory-diseases
#5
REVIEW
Maaike Cockx, Mieke Gouwy, Jo Van Damme, Sofie Struyf
Patients with primary ciliary dyskinesia (PCD) and cystic fibrosis (CF), two inherited disorders, suffer from recurrent airway infections characterized by persistent bacterial colonization and uncontrollable inflammation. Although present in high counts, neutrophils fail to clear infection in the airways. High levels of C-X-C motif chemokine ligand 8/interleukin-8 (CXCL8/IL-8), the most potent chemokine to attract neutrophils to sites of infection, are detected in the sputum of both patient groups and might cause the high neutrophil influx in the airways...
November 27, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29176749/amino-acids-89-96-of-salmonella-flagellin-a-key-site-for-its-adjuvant-effect-independent-of-the-tlr5-signaling-pathway
#6
Xilong Kang, Zhiming Pan, Xinan Jiao
No abstract text is available yet for this article.
November 27, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29176748/roles-of-neddylation-against-viral-infections
#7
Kun Han, Jiyan Zhang
No abstract text is available yet for this article.
November 27, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29176747/the-crucial-roles-of-th17-related-cytokines-signal-pathways-in-m-tuberculosis-infection
#8
REVIEW
Hongbo Shen, Zheng W Chen
Interleukin-17 (IL-17), IL-21, IL-22 and IL-23 can be grouped as T helper 17 (Th17)-related cytokines because they are either produced by Th17/Th22 cells or involved in their development. Here, we review Th17-related cytokines/Th17-like cells, networks/signals and their roles in immune responses or immunity against Mycobacterium tuberculosis (Mtb) infection. Published studies suggest that Th17-related cytokine pathways may be manipulated by Mtb microorganisms for their survival benefits in primary tuberculosis (TB)...
November 27, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29176746/lyve-1-is-on-stage-now-an-emerging-player-in-dendritic-cell-docking-to-lymphatic-endothelial-cells
#9
Elena Rinaldi, Fulvio Baggi
No abstract text is available yet for this article.
November 27, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29176745/aged-t-cells-and-cardiovascular-disease
#10
Min Kyung Jung, Eui-Cheol Shin
No abstract text is available yet for this article.
November 27, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29176744/crucial-role-of-mir-31-in-induction-of-cd8-t-cell-exhaustion-and-reinforcement-of-type-1-interferon-signaling
#11
Lin Ying Li, Inkyu Hwang
No abstract text is available yet for this article.
November 27, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29176743/hcv-immune-evasion-and-regulatory-t-cell-activation-cause-or-consequence
#12
Haijun Li, Tianyang Li, Ian Nicholas Crispe, Zhengkun Tu
No abstract text is available yet for this article.
November 27, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29176742/tlr7-a-third-signal-for-the-robust-generation-of-spontaneous-germinal-center-b-cells-in-systemic-lupus-erythematosus
#13
Hongye Fan, Deshan Ren, Yayi Hou
No abstract text is available yet for this article.
November 27, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29176741/regulation-of-inflammation-and-tumorigenesis-by-the-tipe-family-of-phospholipid-transfer-proteins
#14
Jason R Goldsmith, Youhai H Chen
This corrects the article DOI: 10.1038/cmi.2017.4.
November 27, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29176740/research-progress-in-cytokines-with-chemokine-like-function
#15
Kai Zhang, Shuang Shi, Wenling Han
No abstract text is available yet for this article.
November 27, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29151582/il-1%C3%AE-in-acetaminophen-toxicity-a-sterile-danger-signal
#16
Arvin Iracheta-Vellve, Gyongyi Szabo
No abstract text is available yet for this article.
November 20, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29151581/human-pbmc-transferred-murine-mhc-class-i-ii-deficient-nog-mice-enable-long-term-evaluation-of-human-immune-responses
#17
Tomonori Yaguchi, Asuka Kobayashi, Takashi Inozume, Kenji Morii, Haruna Nagumo, Hiroshi Nishio, Takashi Iwata, Yuyo Ka, Ikumi Katano, Ryoji Ito, Mamoru Ito, Yutaka Kawakami
Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune responses. However, when human peripheral blood mononuclear cells (PBMCs) are transferred into NOG (NOD/Shi-scid, IL-2rg(null)) mice, severe graft versus host disease (GVHD) hinders long term detailed analysis. Administration of human PBMCs into newly developed murine MHC class I- and class II-deficient NOG (NOG-dKO; NOG- Iab, B2m-double-knockout) mice showed sufficient engraftment of human immune cells with little sign of GVHD...
November 20, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29151580/rituximab-or-irradiation-promotes-il-17-secretion-and-thereby-induces-resistance-to-rituximab-or-irradiation
#18
Weijie Zhong, Qingshan Li
No abstract text is available yet for this article.
November 20, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29151579/tlr5-beyond-the-recognition-of-flagellin
#19
Jingyi Yang, Huimin Yan
No abstract text is available yet for this article.
November 20, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29151578/th1-cytokines-true-functional-signatures-for-protective-immunity-against-tb
#20
REVIEW
Gucheng Zeng, Guoliang Zhang, Xinchun Chen
The lack of an effective preventative vaccine against tuberculosis (TB) presents a great challenge to TB control. Since it takes an extremely long time to accurately determine the protective efficacy of TB vaccines, there is a great need to identify the surrogate signatures of protection to facilitate vaccine development. Unfortunately, antigen-specific Th1 cytokines that are currently used to evaluate the protective efficacy of the TB vaccine, do not align with the protection and failure of TB vaccine candidates in clinical trials...
November 20, 2017: Cellular & Molecular Immunology
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