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Cellular & Molecular Immunology

Xiaolei Li, Wenhui Song, Changshun Shao, Yufang Shi, Weidong Han
Checkpoint blockade-based immunotherapy offers new options and powerful weapons for the treatment of cancer, but its efficacy varies greatly among different types of cancer and across individual patients. Thus, the development of the right tools that can be used to identify patients who could benefit from this therapy is of utmost importance in order to maximize the therapeutic benefit, minimize risk of toxicities, and guide combination approaches. Multiple predictors have emerged that are based on checkpoint receptor ligand expression, tumor mutational burden, neoantigen and microsatellite instability, tumor-infiltrating immune cells, and peripheral blood biomarkers...
July 12, 2018: Cellular & Molecular Immunology
Anja Meyer, David M Kofler
No abstract text is available yet for this article.
July 12, 2018: Cellular & Molecular Immunology
Timothy M E Davis, Kirsten E Peters, Richard Lipscombe
No abstract text is available yet for this article.
July 12, 2018: Cellular & Molecular Immunology
Hua Zhang, Chaofeng Han, Tianliang Li, Nan Li, Xuetao Cao
Protein arginine methyltransferases (PRMTs) play diverse biological roles and are specifically involved in immune cell development and inflammation. However, their role in antiviral innate immunity has not been elucidated. Viral infection triggers the TBK1-IRF3 signaling pathway to stimulate the production of type-I interferon, which mediates antiviral immunity. We performed a functional screen of the nine mammalian PRMTs for regulators of IFN-β expression and found that PRMT6 inhibits the antiviral innate immune response...
July 4, 2018: Cellular & Molecular Immunology
Georgios L Moschovakis, Anja Bubke, Michaela Friedrichsen, Jasmin Ristenpart, Jaap Willem Back, Christine S Falk, Elisabeth Kremmer, Reinhold Förster
The chemokine receptor CCR7 and its ligands CCL19 and CCL21 guide the homing and positioning of dendritic and T cells in lymphoid organs, thereby contributing to several aspects of adaptive immunity and immune tolerance. In the present study, we investigated the role of CCR7 in the pathogenesis of collagen-induced arthritis (CIA). By using a novel anti-human CCR7 antibody and humanized CCR7 mice, we evaluated CCR7 as a target in this autoimmune model of rheumatoid arthritis (RA). Ccr7-deficient mice were completely resistant to CIA and presented severely impaired antibody responses to collagen II (CII)...
July 4, 2018: Cellular & Molecular Immunology
Mengjun Zhang, Shufeng Wang, Binbin Guo, Gang Meng, Chi Shu, Wenli Mai, Qian Zheng, Xiaoling Chen, Yuzhang Wu, Li Wang
Autoreactive CD8+ T cells, which play an indispensable role in β cell destruction, represent an emerging target for the prevention of type 1 diabetes (T1D). Altered peptide ligands (APLs) can efficiently induce antigen-specific T cells anergy, apoptosis or shifts in the immune response. Here, we found that HLA-A*0201-restricted CD8+ T cell responses against a primary β-cell autoantigen insulin epitope InsB15-14 were present in both NOD.β2mnull .HHD NOD mice and T1D patients. We generated several APL candidates for InsB15 -14 by residue substitution at the p6 position...
June 28, 2018: Cellular & Molecular Immunology
Ke Wang, Xinwei Zhang, Yifan Wang, Gaowen Jin, Mingyang Li, Shusong Zhang, Jie Hao, Rong Jin, Xiaojun Huang, Hounan Wu, Jun Zhang, Yingyu Chen, Qing Ge
Invariant natural killer T1 (iNKT1) cells are characterized by the preferential expression of T-box transcription factor T-bet (encoded by Tbx21) and the production of cytokine IFN-γ, but the relationship between the developmental process and iNKT1 lineage diversification in the thymus remains elusive. We report in the present study a crucial role of programmed cell death 5 (PDCD5) in iNKT cell terminal maturation and iNKT1 fate determination. Mice with T cell-specific deletion of PDCD5 had decreased numbers of thymic and peripheral iNKT cells with a predominantly immature phenotype and defects in response to α-galactosylceramide...
June 19, 2018: Cellular & Molecular Immunology
Priya Gupta, Manoj K Barthwal
No abstract text is available yet for this article.
June 19, 2018: Cellular & Molecular Immunology
Maurizio Sorice, Roberta Misasi
No abstract text is available yet for this article.
June 19, 2018: Cellular & Molecular Immunology
Bin Gao, Xiaogang Xiang
No abstract text is available yet for this article.
June 19, 2018: Cellular & Molecular Immunology
Sabrina Giampaolo, Gabriela Wójcik, Stefan Klein-Hessling, Edgar Serfling, Amiya K Patra
B cell development in bone marrow is a precisely regulated complex process. Through successive stages of differentiation, which are regulated by a multitude of signaling pathways and an array of lineage-specific transcription factors, the common lymphoid progenitors ultimately give rise to mature B cells. Similar to early thymocyte development in the thymus, early B cell development in bone marrow is critically dependent on IL-7 signaling. During this IL-7-dependent stage of differentiation, several transcription factors, such as E2A, EBF1, and Pax5, among others, play indispensable roles in B lineage specification and maintenance...
June 15, 2018: Cellular & Molecular Immunology
Ja-Young Kwon, Paulomi Aldo, Yuan You, Jiahui Ding, Karen Racicot, Xiaoyan Dong, John Murphy, Guy Glukshtad, Michelle Silasi, Jian Peng, Li Wen, Vikki M Abrahams, Roberto Romero, Gil Mor
Pregnancy is a unique immunologic and microbial condition that requires an adequate level of awareness to provide a fast and protective response against pathogens as well as to maintain a state of tolerance to paternal antigens. Dysregulation of inflammatory pathways in the placenta triggered by pathogens is one of the main factors responsible for pregnancy complications. Type I IFNs are key molecules modulating immune responses at the level of the placenta and are crucial for protection of the pregnancy via their antiviral and immune modulatory properties...
June 15, 2018: Cellular & Molecular Immunology
Svetlana S Sakhnevych, Inna M Yasinska, Alison M Bratt, Ouafa Benlaouer, Isabel Gonçalves Silva, Rohanah Hussain, Giuliano Siligardi, Walter Fiedler, Jasmin Wellbrock, Bernhard F Gibbs, Yuri A Ushkaryov, Vadim V Sumbayev
No abstract text is available yet for this article.
June 15, 2018: Cellular & Molecular Immunology
Jianhua Rao, Feng Cheng, Shikun Yang, Yuan Zhai, Ling Lu
No abstract text is available yet for this article.
June 15, 2018: Cellular & Molecular Immunology
Jessy J Alexander, Richard J Quigg
No abstract text is available yet for this article.
June 5, 2018: Cellular & Molecular Immunology
Inna M Yasinska, Isabel Gonçalves Silva, Svetlana Sakhnevych, Bernhard F Gibbs, Ulrike Raap, Elizaveta Fasler-Kan, Vadim V Sumbayev
Acute myeloid leukaemia (AML) is a blood/bone marrow cancer originating from myeloid cell precusors capable of self-renewing. AML cells implement biochemical mechanisms which allow them not only to survive, but also to successfully escape immune surveillance. ln this work, we discuss crucial molecular mechanisms used by human AML cells in order to evade immune attack.
June 5, 2018: Cellular & Molecular Immunology
Anant Jaiswal, Sukka Santosh Reddy, Mohita Maurya, Preeti Maurya, Manoj Kumar Barthwal
In human adipose tissue and obesity, miR-99a expression is negatively correlated with inflammation. Therefore, the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation. M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and M1 phenotypes. Phenotype-switching experiments established an association between upregulated miR-99a expression and the M2 phenotype. Overexpression of miR-99a prevented M1 phenotype activation and attenuated bactericidal activity...
May 30, 2018: Cellular & Molecular Immunology
Weijun Wu, Ming Qin, Wanwan Jia, Zheng Huang, Zhongzheng Li, Di Yang, Mengwei Huang, Chenxi Xiao, Fen Long, Jianchun Mao, Philip K Moore, Xinhua Liu, Yi Zhun Zhu
Cystathionine-γ-lyase (CSE), an enzyme associated with hydrogen sulfide (H2 S) production, is an important endogenous regulator of inflammation. Jumonji domain-containing protein 3 (JMJD3) is implicated in the immune response and inflammation. Here, we investigated the potential contribution of JMJD3 to endogenous CSE-mediated inflammation in rheumatoid arthritis (RA). Upregulated CSE and JMJD3 were identified in synovial fibroblasts (SFs) from RA patients as well as in the joints of arthritic mice. Knocking down CSE augmented inflammation in IL-1β-induced SFs by increasing JMJD3 expression...
May 29, 2018: Cellular & Molecular Immunology
Yinxiang Wei, Fanghui Zhang, Yu Zhang, Xiaoqian Wang, Chen Xing, Jing Guo, Hui Zhang, Zhimin Suo, Yan Li, Jianli Wang, Renxi Wang, Zhijian Cai
Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which IL-10 is regulated in B cells, we used mRNA microarrays to screen for molecules that are upregulated in IL-10-producing B cells and identified RNA-binding motif protein 47 (Rbm47) as a post-transcriptional regulator. Rbm47 was found to promote IL-10 production in B cells...
May 29, 2018: Cellular & Molecular Immunology
Zhaoru Zhang, Zhen Tang, Xianwei Ma, Kai Sun, Liping Fan, Jie Fang, Jianping Pan, Xiaojian Wang, Huazhang An, Jun Zhou
In this article, published online 5 February 2018, the second primer of mouse actin, il-6, il-1β, TNFα, cxcl1, cxcl2, and ccl20 in Table 2 should be marked as "reverse primer" instead of "forward primer". Corrected Table 2 is shown below. The authors regret the errors.
May 29, 2018: Cellular & Molecular Immunology
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