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Molecular Pain

journal
https://www.readbyqxmd.com/read/29108466/-express-colchicine-alleviates-acute-postoperative-pain-but-delays-wound-repair-in-mice-roles-of-neutrophils-and-macrophages
#1
Asami Sukeishi, Koichi Isami, Haruka Hiyama, Satoshi Imai, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/29108465/-express-polymorphine-provides-extended-analgesic-like-effects-in-mice-with-spared-nerve-injury
#2
Neil C Lax, Renxun Chen, Sarah R Leep, Kathryn Uhrich, Lei Yu, Benedict Kolber
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/29056068/-express-dnmt3a-contributes-to-the-development-and-maintenance-of-bone-cancer-pain-by-silencing-kv1-2-expression-in-spinal-cord-dorsal-horn
#3
Xue-Rong Miao, Long-Chang Fan, Shaogen Wu, Qingxiang Mao, Zhen Li, Brianna Lutz, Ji-Tian Xu, Zhijie Lu, Yuan-Xiang Tao
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/29056067/-express-usefulness-for-the-combination-of-g-protein-and-%C3%AE-arrestin-biased-ligands-of-%C3%AE-opioid-receptors-prevention-of-antinociceptive-tolerance
#4
Tomohisa Mori, Naoko Kuzumaki, Takamichi Arima, Michiko Narita, Ryunosuke Tateishi, Takashige Kondo, Yusuke Hamada, Hirotsugu Kuwata, Miho Kawata, Mitsuaki Yamazaki, Kazuyuki Sugita, Akinobu Matsuzawa, Kanae Baba, Takayasu Yamauchi, Kimio Higashiyama, Miki Nonaka, Kanako Miyano, Yasuhito Uezono, Minoru Narita
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/29056066/-express-monoclonal-antibodies-for-chronic-pain-a-practical-review-of-mechanisms-and-clinical-applications
#5
Ju-Fen Yeh, Aysen Akinci, Mohammed Al Shaker, Ming Hong Chang, Andrei Danilov, Rocio Guileen, Kirk Johnson, Yong-Chul Kim, Ahmed El-Shafei, Vladimir Skljarevski, Hector Duenas, Warat Tassanawipas
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/29020860/-express-group-i-metabotropic-glutamate-receptor-plasticity-after-peripheral-inflammation-alters-nociceptive-transmission-in-the-dorsal-of-the-spinal-cord-in-adult-rats
#6
Houda Radwani, Olivier Roca-Lapirot, Franck Aby, Maria José Lopez-Gonzalez, Rabia Benazzouz, Mohammed Errami, Alexandre Favereaux, Marc Landry, Pascal Fossat
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/29020859/-express-conditional-deletion-of-pip5k1c-in-sensory-ganglia-and-effects-on-nociception-and-inflammatory-sensitization
#7
Lipin Loo, Mark Zylka
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28969475/-express-peripheral-and-orofacial-pain-sensation-is-unaffected-by-the-loss-of-p39
#8
Michaela Prochazkova, Bradford Hall, Minghan Hu, Tracy Okine, Jennifer Reukauf, B K Binukumar, Niranjana D Amin, Eva Roque, Harish C Pant, Ashok Kulkarni
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28969474/-express-affection-of-comt1-genetype-on-anxiety-and-nociceptive-sensitivity-an-ego-network-analysis-approach
#9
Wenzheng Li, Shoutao Zhao, Zhenhong Zhang
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28969473/-express-brain-natriuretic-peptide-bnp-expressing-sensory-neurons-are-not-involved-in-acute-inflammatory-or-neuropathic-pain
#10
Saumitra Pitake, Jennifer Debrecht, Santosh Kumar Mishra
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28969472/-express-propofol-produces-preventive-analgesia-via-glun2b-containing-nmda-receptor-erk1-2-signaling-pathway-in-a-rat-model-of-inflammatory-pain
#11
Qiu Qiu, Liting Sun, Xiao-Min Wang, Amy C Y Lo, Kar Lok Wong, Pan Gu, Sau Ching Stanley Wong, Chi Wai Cheung
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28969471/-express-abnormal-functional-integration-across-core-brain-networks-in-migraine-without-aura
#12
Dahua Yu, Kai Yuan, Lin Luo, Jinquan Zhai, Yanzhi Bi, Ting Xue, Xiaoying Ren, Ming Zhang, Guoyin Ren, Xiaoqi Lu
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28952414/src-family-kinases-activation-in-spinal-microglia-contributes-to-central-sensitization-and-chronic-pain-after-lumbar-disc-herniation
#13
Yangliang Huang, Yongyong Li, Xiongxiong Zhong, Yuming Hu, Pan Liu, Yuanshu Zhao, Zhen Deng, Xianguo Liu, Shaoyu Liu, Yi Zhong
Background Lumbar disc herniation is a major cause of radicular pain, but the underlying mechanisms remain largely unknown. Spinal activation of src-family kinases are involved in the development of chronic pain from nerve injury, inflammation, and cancer. In the present study, the role of src-family kinases activation in lumbar disc herniation-induced radicular pain was investigated. Results Lumbar disc herniation was induced by implantation of autologous nucleus pulposus, harvest from tail, in lumbar 4/5 spinal nerve roots of rat...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28929859/endotracheal-tube-induced-sore-throat-pain-and-inflammation-is-coupled-to-the-release-of-mitochondrial-dna
#14
Carlos A Puyo, Daniela Peruzzi, Alexander Earhart, Evan Roller, Menelaos Karanikolas, Marin H Kollef, Alexander S Krupnick, Daniel Kreisel, Mohsen Ibrahim, Andrew E Gelman
In the absence of infection, the pathophysiology of endotracheal tube-induced sore throat pain is unclear. Activated neutrophils release elastase, reactive oxygen species, and inflammatory cytokines known to contribute to neuropathic pain. Sterile tissue injury can cause the release of damage-associated molecular patterns such as mitochondrial DNA that promote neutrophil activation. We hypothesized that endotracheal tube-induced sore throat pain is linked to mitochondrial DNA-mediated neutrophil inflammation...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28879802/anti-nociceptive-interactions-between-opioids-and-a-cannabinoid-receptor-2-agonist-in-inflammatory-pain
#15
Matthew B Yuill, David E Hale, Josée Guindon, Daniel J Morgan
The cannabinoid 1 receptor and cannabinoid 2 receptor can both be targeted in the treatment of pain; yet, they have some important differences. Cannabinoid 1 receptor is expressed at high levels in the central nervous system, whereas cannabinoid 2 receptor is found predominantly, although not exclusively, outside the central nervous system. The objective of this study was to investigate potential interactions between cannabinoid 2 receptor and the mu-opioid receptor in pathological pain. The low level of adverse side effects and lack of tolerance for cannabinoid 2 receptor agonists are attractive pharmacotherapeutic traits...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28868961/serotonin-gated-inward-currents-are-three-times-more-frequent-in-rat-hairy-skin-sensory-afferents-than-in-those-innervating-the-skeletal-muscle
#16
Leonardo Fierro
Tight whole-cell patch clamp was performed in 191 DiI (1,1'-dioctadecyl-3,3,3'3'-tetramethylindocarbocyanine perchlorate) retrogradely labeled rat sensory afferents from skin shoulders ( n = 93) and biceps femoris muscles ( n = 98). 5-HT-gated inward currents were evoked with 50-µM serotonin (5-HT; 5-hydroxytryptamine), and their frequency and current densities were compared between skin and skeletal muscle sensory afferents. To evaluate if 5-HT-gated inward currents coexist with other ligand-gated currents, the skin and skeletal muscle sensory afferents were also sequentially exposed to external solution at pH 6...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28849714/pain-vulnerability-and-dna-methyltransferase-3a-involved-in-the-affective-dimension-of-chronic-pain
#17
Wei Wang, Caiyue Li, Youqing Cai, Zhizhong Z Pan
Chronic pain with comorbid emotional disorders is a prevalent neurological disease in patients under various pathological conditions, yet patients show considerable difference in their vulnerability to developing chronic pain. Understanding the neurobiological basis underlying this pain vulnerability is essential to develop targeted therapies of higher efficiency in pain treatment of precision medicine. However, this pain vulnerability has not been addressed in preclinical pain research in animals to date. In this study, we investigated individual variance in both sensory and affective/emotional dimensions of pain behaviors in response to chronic neuropathic pain condition in a mouse model of chronic pain...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28849713/upregulation-of-cx3cl1-mediated-by-nf-%C3%AE%C2%BAb-activation-in-dorsal-root-ganglion-contributes-to-peripheral-sensitization-and-chronic-pain-induced-by-oxaliplatin-administration
#18
Jing Wang, Xin-Sheng Zhang, Rong Tao, Jie Zhang, Lin Liu, Ying-Hai Jiang, Song-He Ma, Lin-Xia Song, Ling-Jie Xia
Painful peripheral neuropathy is a severe side effect in oxaliplatin therapy that compromises cancer patients' quality of life. However, its underlying pathogenic mechanisms remain largely unknown. Here, we found that intraperitoneal consecutive administration of oxaliplatin significantly increased excitability of small diameter dorsal root ganglion neurons and induced thermal hyperalgesia in rats. Furthermore, the CX3CL1 expression was significantly increased after oxaliplatin treatment, and intrathecal injection of a neutralizing antibody against CX3CL1 markedly attenuated the enhanced excitability of dorsal root ganglion neurons and thermal hyperalgesia...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28845733/-express-the-chemokine-receptor-cxcr2-supports-nociceptive-sensitization-after-traumatic-brain-injury
#19
De-Yong Liang, Xiaoyou Shi, Peng Liu, Yuan Sun, Peyman Sahbaie, Wen-Wu Li, David C Yeomans, J David Clark
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28845732/-express-kindlin-1-is-a-key-protein-in-hyperbaric-oxygen-therapy-for-the-treatment-of-neuropathic-pain
#20
Baisong Zhao, Erning He, Yongying Pan, Haiping Xu, Xingrong Song
No abstract text is available yet for this article.
January 2017: Molecular Pain
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