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Molecular Pain

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https://www.readbyqxmd.com/read/28879802/anti-nociceptive-interactions-between-opioids-and-a-cannabinoid-receptor-2-agonist-in-inflammatory-pain
#1
Matthew B Yuill, David E Hale, Josée Guindon, Daniel J Morgan
The cannabinoid 1 receptor and cannabinoid 2 receptor can both be targeted in the treatment of pain; yet, they have some important differences. Cannabinoid 1 receptor is expressed at high levels in the central nervous system, whereas cannabinoid 2 receptor is found predominantly, although not exclusively, outside the central nervous system. The objective of this study was to investigate potential interactions between cannabinoid 2 receptor and the mu-opioid receptor in pathological pain. The low level of adverse side effects and lack of tolerance for cannabinoid 2 receptor agonists are attractive pharmacotherapeutic traits...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28868961/serotonin-gated-inward-currents-are-three-times-more-frequent-in-rat-hairy-skin-sensory-afferents-than-in-those-innervating-the-skeletal-muscle
#2
Leonardo Fierro
Tight whole-cell patch clamp was performed in 191 DiI (1,1'-dioctadecyl-3,3,3'3'-tetramethylindocarbocyanine perchlorate) retrogradely labeled rat sensory afferents from skin shoulders ( n = 93) and biceps femoris muscles ( n = 98). 5-HT-gated inward currents were evoked with 50-µM serotonin (5-HT; 5-hydroxytryptamine), and their frequency and current densities were compared between skin and skeletal muscle sensory afferents. To evaluate if 5-HT-gated inward currents coexist with other ligand-gated currents, the skin and skeletal muscle sensory afferents were also sequentially exposed to external solution at pH 6...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28849714/pain-vulnerability-and-dna-methyltransferase-3a-involved-in-the-affective-dimension-of-chronic-pain
#3
Wei Wang, Caiyue Li, Youqing Cai, Zhizhong Z Pan
Chronic pain with comorbid emotional disorders is a prevalent neurological disease in patients under various pathological conditions, yet patients show considerable difference in their vulnerability to developing chronic pain. Understanding the neurobiological basis underlying this pain vulnerability is essential to develop targeted therapies of higher efficiency in pain treatment of precision medicine. However, this pain vulnerability has not been addressed in preclinical pain research in animals to date. In this study, we investigated individual variance in both sensory and affective/emotional dimensions of pain behaviors in response to chronic neuropathic pain condition in a mouse model of chronic pain...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28849713/upregulation-of-cx3cl1-mediated-by-nf-%C3%AE%C2%BAb-activation-in-dorsal-root-ganglion-contributes-to-peripheral-sensitization-and-chronic-pain-induced-by-oxaliplatin-administration
#4
Jing Wang, Xin-Sheng Zhang, Rong Tao, Jie Zhang, Lin Liu, Ying-Hai Jiang, Song-He Ma, Lin-Xia Song, Ling-Jie Xia
Painful peripheral neuropathy is a severe side effect in oxaliplatin therapy that compromises cancer patients' quality of life. However, its underlying pathogenic mechanisms remain largely unknown. Here, we found that intraperitoneal consecutive administration of oxaliplatin significantly increased excitability of small diameter dorsal root ganglion neurons and induced thermal hyperalgesia in rats. Furthermore, the CX3CL1 expression was significantly increased after oxaliplatin treatment, and intrathecal injection of a neutralizing antibody against CX3CL1 markedly attenuated the enhanced excitability of dorsal root ganglion neurons and thermal hyperalgesia...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28845733/-express-the-chemokine-receptor-cxcr2-supports-nociceptive-sensitization-after-traumatic-brain-injury
#5
De-Yong Liang, Xiaoyou Shi, Peng Liu, Yuan Sun, Peyman Sahbaie, Wen-Wu Li, David C Yeomans, J David Clark
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28845732/-express-kindlin-1-is-a-key-protein-in-hyperbaric-oxygen-therapy-for-the-treatment-of-neuropathic-pain
#6
Baisong Zhao, Erning He, Yongying Pan, Haiping Xu, Xingrong Song
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28845731/-express-upregulation-of-p2y1-in-neonatal-nociceptors-regulates-heat-and-mechanical-sensitization-during-cutaneous-inflammation
#7
Peilin Lu, Renita C Hudgins, Xiaohua Liu, Zachary K Ford, Megan C Hofmann, Luis F Queme, Michael Paul Jankowski
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28825338/intraoperative-electroacupuncture-relieves-remifentanil-induced-postoperative-hyperalgesia-via-inhibiting-spinal-glial-activation-in-rats
#8
Changxi Shi, Yue Liu, Wei Zhang, Yishan Lei, Cui'e Lu, Rao Sun, Yu'e Sun, Ming Jiang, Xiaoping Gu, Zhengliang Ma
Background Accumulating studies have suggested that remifentanil, the widely-used opioid analgesic in clinical anesthesia, can activate the pronociceptive systems and enhance postoperative pain. Glial cells are thought to be implicated in remifentanil-induced hyperalgesia. Electroacupuncture is a complementary therapy to relieve various pain conditions with few side effects, and glial cells may be involved in its antinociceptive effect. In this study, we investigated whether intraoperative electroacupuncture could relieve remifentanil-induced postoperative hyperalgesia by inhibiting the activation of spinal glial cells, the production of spinal proinflammatory cytokines, and the activation of spinal mitogen-activated protein kinases...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28825337/post-discharge-hyperpolarization-is-an-endogenous-modulatory-factor-limiting-input-from-fast-conducting-nociceptors-ahtmrs
#9
M Danilo Boada, Douglas G Ririe, James C Eisenach
Peripheral somatosensory neurons are frequently exposed to mechanical forces. Strong stimuli result in neuronal activation of high-threshold mechanosensory afferent neurons, even in the absence of tissue damage. Among these neurons, fast-conducting nociceptors (A-fiber high-threshold mechanoreceptors (AHTMRs)) are normally resistant to sustained activation, transiently encoding the mechanical stimulus intensity but not its full duration. This rapidly adapting response seems to depend on changes in the electrical excitability of the membrane of these afferent neurons during sustained stimulation, a restraint mechanism that disappears following sensitization...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28814148/-express-could-an-endoneurial-endothelial-crosstalk-between-wnt-%C3%AE-catenin-and-sonic-hedgehog-pathways-underlie-the-early-disruption-of-the-infra-orbital-blood-nerve-barrier-following-chronic-constriction-injury
#10
Nathan Moreau, Annie Mauborgne, Pierre-Olivier Couraud, Ignacio A Romero, Babette B Weksler, Luis Villanueva, Michel Pohl, Yves Boucher
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28814147/-express-threshold-effect-of-g9a-glp-on-peripheral-nerve-injury-induced-hypersensitivity
#11
Xian Wang, Xiaofeng Shen, Shaolei Ma, Yusheng Liu, Shiqin Xu, Shizheng Wu, Fuzhou Wang
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28814146/-express-evidence-that-dry-eye-represents-a-chronic-overlapping-pain-condition
#12
Alexandra E Levitt, Anat Galor, Aneesa R Chowdhury, Elizabeth R Felix, Constantinos D Sarantopoulos, Gerald Y Zhuang, Dennis Patin, William Maixner, Shad B Smith, Eden R Martin, Roy C Levitt
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28814145/-express-analgesia-by-deletion-of-spinal-neurokinin-1-receptor-expressing-neurons-using-a-bioengineered-substance-p-pseudomonas-exotoxin-conjugate
#13
Michael J Iadarola, Matthew R Sapio, Xunde Wang, Hector Carrero, Maria Luisa Virata-Theimer, Robert Sarnovsky, Andrew J Mannes, David J FitzGerald
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28814144/-express-intrathecal-administration-of-ayx2-dna-decoy-produces-a-long-term-pain-treatment-in-rat-models-of-chronic-pain-by-inhibiting-the-klf6-klf9-and-klf15-transcription-factors
#14
Julien Mamet, Michael Klukinov, Scott Harris, Donald C Manning, Simon Xie, Conrado Pascual, Bradley K Taylor, Renee R Donahue, David C Yeomans
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28812431/oral-administration-of-curcumin-attenuates-visceral-hyperalgesia-through-inhibiting-phosphorylation-of-trpv1-in-rat-model-of-ulcerative-colitis
#15
Mei Yang, Juan Wang, Chunxue Yang, Hongxiu Han, Weifang Rong, Guohua Zhang
Background Curcumin has been reported to have anti-inflammatory and anti-nociceptive effects. The present study was designed to explore the potential therapeutic effects of curcumin on visceral hyperalgesia and inflammation in a rat model of ulcerative colitis. We observed the effects of orally administered curcumin on the disease activity index, histological change in colon, colorectal distension-induced abdominal withdrawal reflex, the expression of transient receptor potential vanilloid 1 (TRPV1) and phosphorylated TRPV1 in dextran sulfate sodium-induced colitis rats...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28776455/chronic-changes-in-pituitary-adenylate-cyclase-activating-polypeptide-and-related-receptors-in-response-to-repeated-chemical-dural-stimulation-in-rats
#16
Xun Han, Ye Ran, Min Su, Yinglu Liu, Wenjing Tang, Zhao Dong, Shengyuan Yu
Background Preclinical experimental studies revealed an acute alteration of pituitary adenylate cyclase-activating polypeptide in response to a single activation of the trigeminovascular system, which suggests a potential role of pituitary adenylate cyclase-activating polypeptide in the pathogenesis of migraine. However, changes in pituitary adenylate cyclase-activating polypeptide after repeated migraine-like attacks in chronic migraine are not clear. Therefore, the present study investigated chronic changes in pituitary adenylate cyclase-activating polypeptide and related receptors in response to repeated chemical dural stimulations in the rat...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28758541/cobra-neurotoxin-produces-central-analgesic-and-hyperalgesic-actions-via-adenosine-a1-and-a2a-receptors
#17
Chuang Zhao, Jun Zhao, Qian Yang, Yong Ye
Cobra neurotoxin, a short-chain peptide isolated from snake venom of Naja naja atra, showed both a central analgesic effect and a hyperalgesic effect in mice tests. In order to explore mechanisms, a hypothesis is put forward that cobra neurotoxin takes effect through adenosine receptor pathway. The central effects of cobra neurotoxin were evaluated using the hot plate test (a model of acute pain) and the spinal cord injury (a model of central pain) in mice and using A1 receptor antagonist (DPCPX) and A2A receptor antagonist (ZM241385); behaviors were scored and signal molecules such as reactive oxygen species and adenosine triphosphate levels and mitogen-activated protein kinases/extracellular signal-regulated protein kinase expression were measured...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28745101/acidosis-counteracts-itch-tachyphylaxis-to-consecutive-pruritogen-exposure-dependent-on-acid-sensing-ion-channel-3
#18
Yi-Ming Jiang, Chen Huang, Zhong Peng, Shao-Ling Han, Wei-Guang Li, Michael Xi Zhu, Tian-Le Xu
Tachyphylaxis of itch refers to a markedly reduced scratching response to consecutive exposures of a pruritogen, a process thought to protect against tissue damage by incessant scratching and to become disrupted in chronic itch. Here, we report that a strong stimulation of the Mas-related G-protein-coupled receptor C11 by its agonist, Ser-Leu-Ile-Gly-Arg-Leu-NH2 (SL-NH2) or bovine adrenal medulla 8-22 peptide, via subcutaneous injection in mice induces tachyphylaxis to the subsequent application of SL-NH2 to the same site...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28741447/-express-single-nucleotide-polymorphism-in-the-col11a2-gene-associated-with-heat-pain-sensitivity-in-knee-osteoarthritis
#19
Kwo Wei David Ho, Margaret R Wallace, Kimberly T Sibille, Emily J Bartley, Yenisel Cruz-Almeida, Toni L Glover, Christopher D King, Burel R Goodin, Adriana Addison, Jeffrey C Edberg, Roland Staud, Laurence A Bradley, Roger B Fillingim
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28741433/-express-immune-system-involvement-in-specific-pain-conditions
#20
Stacie K Totsch, Robert Ernest Sorge
No abstract text is available yet for this article.
January 2017: Molecular Pain
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