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Molecular Pain

Chuchu Qi, Baolin Guo, Keke Ren, Han Yao, Mengmeng Wang, Tangna Sun, Guohong Cai, Haiying Liu, Rui Li, Ceng Luo, Wenting Wang, Sheng-Xi Wu
Reward system has been proved to be important to nociceptive behavior, and the nucleus accumbens (NAc) is a key node in reward circuitry. It has been further revealed that dopamine system modulates the NAc to influence the pain sensation, whereas the role of glutamatergic projection in the NAc in the modulation of chronic pain is still elusive. In this study, we used a Complete Freund adjuvant (CFA) -induced chronic inflammatory pain model to explore the changes of the glutamatergic terminals in the NAc, and we found that following the chronic inflammation, the protein level of vesicular glutamate transporters1 (VGLUT1) was significant decreased in the NAc...
January 1, 2018: Molecular Pain
Xingzhu Geng, Yanshan Liu, Xiuzhi Ren, Yun Guan, Yanzhou Wang, Bin Mao, Xiuli Zhao, Xue Zhang
Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disorder, characterized by loss of algesthesis and inability to sweat. CIPA is known to be caused by mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1). However, the details of NTRK1 mutations in Chinese CIPA patients remain unclear. In the present study, we recruited 36 CIPA patients from 34 unrelated families in mainland China. Blood samples from these patients and their available familial members were collected and subjected to genetic analysis...
January 1, 2018: Molecular Pain
Juan Bai, F U Liu, Li-Fei Wu, Ya-Fang Wang, Xia-Qing Li
AIMS: The main objective was to investigate the effects of the transient receptor potential cation channel subfamily V member 1 (TRPV1) on nerve regeneration following sciatic transection injury by functional blockage of TRPV1 using AMG-517, a specific blocker of TRPV1. METHODS: AMG-517 was injected into the area surrounding ipsilateral lumbar dorsal root ganglia (DRGs) 30 min after unilateral sciatic nerve transection. The number of sciatic axons and the expression of growth associated protein-43 (GAP-43) and glial fibrillary acidic protein (GFAP) were examined using semi-thin sections, western blot, and immunofluorescence analyses...
January 1, 2018: Molecular Pain
Tanya Miladinovic, Robert G Ungard, Katja Linher-Melville, Snezana Popovic, Gurmit Singh
Breast cancer cells release the signalling molecule glutamate via the system xC - antiporter, which is upregulated to exchange extracellular cystine for intracellular glutamate to protect against oxidative stress. Here, we demonstrate that this antiporter is functionally influenced by the actions of the neurotrophin nerve growth factor on its cognate receptor tyrosine kinase, TrkA, and that inhibiting this complex may reduce cancer-induced bone pain via its downstream actions on xCT, the functional subunit of system xC - ...
January 2018: Molecular Pain
Hong-Jun Wang, Xue Xu, Rui-Hua Xie, Yun-Yun Rui, Ping-An Zhang, Xiao-Jue Zhu, Guang-Yin Xu
Irritable bowel syndrome (IBS) is a disorder of unknown etiology characterized by widespread, chronic abdominal pain associated with altered bowel movements. Increasing amounts of evidence indicate that stressors presented during gestational periods could have long-term effects on the offspring's tissue structure and function, which may predispose to gastrointestinal diseases. The aim of the present study is designed to determine whether prenatal maternal stress (PMS) is a adverse factor affecting gastrointestinal sensitivity and to investigate possible mechanisms underlying PMS-induced visceral hypersensitivity in adult offspring...
January 1, 2018: Molecular Pain
Xiao-Bo Wu, Li-Na He, Bao-Chun Jiang, Hui Shi, Xue-Qiang Bai, Wen-Wen Zhang, Yong-Jing Gao
Chemokines-mediated neuroinflammation in the spinal cord plays a critical role in the pathogenesis of neuropathic pain. Chemokine CXCL9, CXCL10 and CXCL11 have been identified as a same subfamily chemokine which bind to CXC chemokine receptor 3 (CXCR3) to exert functions. Our recent work found that CXCL10 is upregulated in spinal astrocytes after spinal nerve ligation (SNL), and acts on CXCR3 on neurons to contribute to central sensitization and neuropathic pain, but less is known about CXCL9 and CXCL11 in the maintenance of neuropathic pain...
January 1, 2018: Molecular Pain
Sun Up Noh, Won-Young Lee, Won-Serk Kim, Yong-Taek Lee, Kyung Jae Yoon
Background Diabetic neuropathy (DN) originating in distal lower extremities is associated with pain early in the disease course, overwhelming in the feet. However, the pathogenesis of DN remains unclear. Macrophage migration inhibitory factor (MIF) has been implicated in the onset of neuropathic pain and the development of diabetes. Objective of this study was to observe pain syndromes elicited in the footpad of DN rat model and to assess the contributory role of MIF in the pathogenesis of DN. Methods DN was made in SD rats by streptozotocin (STZ)...
January 1, 2018: Molecular Pain
Nan Zhou, Shuang Hao, Zongqiang Huang, Weiwei Wang, Penghui Yan, Wei Zhou, Qihang Zhu, Xiaokang Liu
Objective Neural stem cells play an important role in the recovery and regeneration of peripheral nerve injury, and the microRNA-7 (miR-7) regulates differentiation of neural stem cells. This study aimed to explore the role of miR-7 in neural stem cells homing and proliferation and its influence on peripheral nerve injury repair. Methods The mice model of peripheral nerve injury was created by segmental sciatic nerve defect (sciatic nerve injury), and neural stem cells treatment was performed with a gelatin hydrogel conduit containing neural stem cells inserted into the sciatic nerve injury mice...
January 2018: Molecular Pain
Xiaoyu Zhang, Zhiqiang Zhang, Jianzhong Wen, Jie Lu, Yingchun Sun, Dechun Sang
Objectives The aim of this network meta-analysis is to assess the effectiveness of therapeutic strategies for patients with radiculopathy, including physical, medical, surgical, and other therapies. Methods We electronically searched electronic databases including PubMed and Embase for randomized controlled trials. The response rate and visual analog scale of pain change were considered as primary outcomes. The outcomes were measured by odds ratio (OR) value and corresponding 95% credible intervals (CrIs) or standardized mean difference (MD) with 95% CrIs...
January 2018: Molecular Pain
Min Su, Shengyuan Yu
Chronic migraine is a common chronic daily headache featured by frequent headache attacks with at least 15 headache days per month, which brings great disease burden to both the sufferers and the society. Transformed from episodic migraine, the pathophysiology of chronic migraine is not fully understood, even though several risk factors have been associated with migraine progression. Recent studies have identified both structural and functional alterations in some brain regions of chronic migraine patients indicating that maladaptation of the top-down pain modulation and subsequent sensitization of trigeminal system may be important in the pathogenesis of chronic migraine...
January 2018: Molecular Pain
Yulong Gui, Jie Zhang, Liang Chen, Shunyuan Duan, Jing Tang, Wei Xu, Aiyuan Li
Background One of the most common side effects of paclitaxel was dosage-dependently painful neuropathy. Various reports indicated that spinal neuroinflammation was involved in paclitaxel-induced neuropathic pain. This study investigated the effect of icariin on paclitaxel-induced neuroinflammation and peripheral neuropathy in rats. Methods Two parts were included in this study. In part one, the effect of icariin on paclitaxel-induced neuropathic pain was investigated. Mechanical thresholds were measured as primary outcomes...
January 2018: Molecular Pain
Su Liu, You Lv, Xin-Xin Wan, Zhi-Jing Song, Yue-Peng Liu, Shuai Miao, Guang-Lei Wang, Gong-Jian Liu
Treating bone cancer pain continues to be a clinical challenge and underlying mechanisms of bone cancer pain remain elusive. Here, we reported that sonic hedgehog signaling plays a critical role in the development of bone cancer pain. Tibia bone cavity tumor cell implantation produces bone cancer-related mechanical allodynia, thermal hyperalgesia, and spontaneous and movement-evoked pain behaviors. Production and persistence of these pain behaviors are well correlated with tumor cell implantation-induced up-regulation and activation of sonic hedgehog signaling in primary sensory neurons and spinal cord...
January 2018: Molecular Pain
Shuo Zhang, Tianjiao Li, Hiroyuki Kobinata, Eri Ikeda, Takashi Ota, Jiro Kurata
Background Offset analgesia is a disproportionate decrease of pain perception following a slight decrease of noxious thermal stimulus and attenuated in patients with neuropathic pain. We examined offset analgesia in patients with heterogeneous chronic pain disorders and used functional magnetic resonance imaging to explore modification of cerebral analgesic responses in comparison with healthy controls. Results We recruited seventeen patients with chronic pain and seventeen age-, sex-matched healthy controls...
January 2018: Molecular Pain
Xue-Jing Kang, Ye-Nan Chi, Wen Chen, Feng-Yu Liu, Shuang Cui, Fei-Fei Liao, Jie Cai, You Wan
Ion channels are very important in the peripheral sensitization in neuropathic pain. Our present study aims to investigate the possible contribution of CaV 3.2 T-type calcium channels in damaged dorsal root ganglion neurons in neuropathic pain. We established a neuropathic pain model of rats with spared nerve injury. In these model rats, it was easy to distinguish damaged dorsal root ganglion neurons (of tibial nerve and common peroneal nerve) from intact dorsal root ganglion neurons (of sural nerves). Our results showed that CaV 3...
January 2018: Molecular Pain
Yuanyuan Ding, Peng Yao, Tao Hong, Hongxi Li, Yongqiang Zhu, Zhenkai Han, Guangyu Zhou
Objective To observe the analgesic effect of early hyperbaric oxygen (HBO) treatment in chronic constriction injury (CCI) rats, and to analyze the influence of HBO on the expression of neuronal nitric oxide synthase and inducible nitric oxide synthase and on the levels of inflammatory factors. Methods Rats were assigned into three groups randomly: sham, CCI, and HBO groups. The CCI rat model was established, and HBO treatment at 2.5 ATA (60 min) was given one day after surgery, lasting for five consecutive days...
January 2018: Molecular Pain
Shunsuke Yamakita, Yasuhiko Horii, Hitomi Takemura, Yutaka Matsuoka, Ayahiro Yamashita, Yosuke Yamaguchi, Megumi Matsuda, Teiji Sawa, Fumimasa Amaya
Background Intense nociceptive signaling arising from ongoing injury activates primary afferent nociceptive systems to generate peripheral sensitization. ERK1/2 phosphorylation in dorsal root ganglion can be used to visualize intracellular signal activity immediately after noxious stimulation. The aim of this study was to investigate spatiotemporal characteristics of ERK1/2 phosphorylation against tissue injury in the primary afferent neurons. Methods Plantar incisions were made in the hind paws of Sprague-Dawley rats (n =150)...
January 2018: Molecular Pain
Mu Xu, Zhigang Cheng, Zhuofeng Ding, Yunjiao Wang, Qulian Guo, Changsheng Huang
Resveratrol has been showed to relieve neuropathic pain through its anti-inflammatory effects on the peripheral nerve system. However, it is not clear whether resveratrol, especially when administered systemically, is effective in alleviating the peripheral neuropathy-induced imbalance between pro- and anti-inflammatory responses in the central nervous system. To test this, we used a rat neuropathic pain model resulting from chronic constriction injury of the sciatic nerve. Resveratrol (200 mg/kg) or vehicle (dimethylsulfoxide) were administered intraperitoneally once daily for 14 consecutive days after chronic constriction injury...
January 2018: Molecular Pain
Jing-Shan Lu, Qian Song, Ming-Ming Zhang, Min Zhuo
Background The enhanced expression of cytokines in the pathological states suggests that they have important roles in the initiation or maintenance of disease states. FINDINGS: To determine the involvement of cytokines in chronic neuropathic pain, the expression of cytokines in the anterior cingulate cortex neurons in the ligation of the common peroneal nerve mice was investigated. We utilized a cytokine enzyme-linked immunosorbent assay plate array to detect 23 cytokines in total eight mice including a female, and no significant differences were found in those cytokines between the common peroneal nerve model and sham surgery mice...
January 2018: Molecular Pain
Ruijuan Guo, Huili Li, Xueyang Li, Zhaojing Xue, Yuqing Sun, Danxu Ma, Yun Guan, Junfa Li, Ming Tian, Yun Wang
Neuroligin1 is an important synaptic cell adhesion molecule that modulates the function of synapses through protein-protein interactions. Yet, it remains unclear whether the regulation of synaptic transmission in the spinal cord by neruoligin1 contributes to the development of postoperative pain. In a rat model of postoperative pain induced by plantar incision, we conducted Western blot study to examine changes in the expression of postsynaptic membrane of neuroligin1, postsynaptic density 95 (PSD-95), and α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor GluA1 and GluA2 subunits in the spinal cord dorsal horn after injury...
January 2018: Molecular Pain
Fenghua Bao, Chang-Lin Li, Xu-Qiao Chen, Ying-Jin Lu, Lan Bao, Xu Zhang
Opioid receptors play an important role in mediating the spinal analgesia. The μ-opioid receptor (MOR) is the major target of opioid drugs widely used in clinics. However, the regulatory mechanisms of analgesic effect and tolerance for clinical MOR-targeting opioids remain to be fully investigated. Previous studies showed the interaction of δ-opioid receptor (DOR) with MOR to form the MOR/DOR heteromers that could be processed in the degradation pathway after DOR agonist treatment. Here we showed that clinical MOR-targeting opioids, morphine, fentanyl and methadone, but not tramadol, caused MOR co-internalization with DORs in both transfected human embryonic kidney 293 cells and primary sensory neurons...
January 1, 2018: Molecular Pain
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