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Molecular Pain

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https://www.readbyqxmd.com/read/28814148/-express-could-an-endoneurial-endothelial-crosstalk-between-wnt-%C3%AE-catenin-and-sonic-hedgehog-pathways-underlie-the-early-disruption-of-the-infra-orbital-blood-nerve-barrier-following-chronic-constriction-injury
#1
Nathan Moreau, Annie Mauborgne, Pierre-Olivier Couraud, Ignacio A Romero, Babette B Weksler, Luis Villanueva, Michel Pohl, Yves Boucher
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28814147/-express-threshold-effect-of-g9a-glp-on-peripheral-nerve-injury-induced-hypersensitivity
#2
Xian Wang, Xiaofeng Shen, Shaolei Ma, Yusheng Liu, Shiqin Xu, Shizheng Wu, Fuzhou Wang
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28814146/-express-evidence-that-dry-eye-represents-a-chronic-overlapping-pain-condition
#3
Alexandra E Levitt, Anat Galor, Aneesa R Chowdhury, Elizabeth R Felix, Constantinos D Sarantopoulos, Gerald Y Zhuang, Dennis Patin, William Maixner, Shad B Smith, Eden R Martin, Roy C Levitt
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28814145/-express-analgesia-by-deletion-of-spinal-neurokinin-1-receptor-expressing-neurons-using-a-bioengineered-substance-p-pseudomonas-exotoxin-conjugate
#4
Michael J Iadarola, Matthew R Sapio, Xunde Wang, Hector Carrero, Maria Luisa Virata-Theimer, Robert Sarnovsky, Andrew J Mannes, David J FitzGerald
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28814144/-express-intrathecal-administration-of-ayx2-dna-decoy-produces-a-long-term-pain-treatment-in-rat-models-of-chronic-pain-by-inhibiting-the-klf6-klf9-and-klf15-transcription-factors
#5
Julien Mamet, Michael Klukinov, Scott Harris, Donald C Manning, Simon Xie, Conrado Pascual, Bradley K Taylor, Renee R Donahue, David C Yeomans
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28812431/oral-administration-of-curcumin-attenuates-visceral-hyperalgesia-through-inhibiting-phosphorylation-of-trpv1-in-rat-model-of-ulcerative-colitis
#6
Mei Yang, Juan Wang, Chunxue Yang, Hongxiu Han, Weifang Rong, Guohua Zhang
Background Curcumin has been reported to have anti-inflammatory and anti-nociceptive effects. The present study was designed to explore the potential therapeutic effects of curcumin on visceral hyperalgesia and inflammation in a rat model of ulcerative colitis. We observed the effects of orally administered curcumin on the disease activity index, histological change in colon, colorectal distension-induced abdominal withdrawal reflex, the expression of transient receptor potential vanilloid 1 (TRPV1) and phosphorylated TRPV1 in dextran sulfate sodium-induced colitis rats...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28776455/chronic-changes-in-pituitary-adenylate-cyclase-activating-polypeptide-and-related-receptors-in-response-to-repeated-chemical-dural-stimulation-in-rats
#7
Xun Han, Ye Ran, Min Su, Yinglu Liu, Wenjing Tang, Zhao Dong, Shengyuan Yu
Background Preclinical experimental studies revealed an acute alteration of pituitary adenylate cyclase-activating polypeptide in response to a single activation of the trigeminovascular system, which suggests a potential role of pituitary adenylate cyclase-activating polypeptide in the pathogenesis of migraine. However, changes in pituitary adenylate cyclase-activating polypeptide after repeated migraine-like attacks in chronic migraine are not clear. Therefore, the present study investigated chronic changes in pituitary adenylate cyclase-activating polypeptide and related receptors in response to repeated chemical dural stimulations in the rat...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28758541/cobra-neurotoxin-produces-central-analgesic-and-hyperalgesic-actions-via-adenosine-a1-and-a2a-receptors
#8
Chuang Zhao, Jun Zhao, Qian Yang, Yong Ye
Cobra neurotoxin, a short-chain peptide isolated from snake venom of Naja naja atra, showed both a central analgesic effect and a hyperalgesic effect in mice tests. In order to explore mechanisms, a hypothesis is put forward that cobra neurotoxin takes effect through adenosine receptor pathway. The central effects of cobra neurotoxin were evaluated using the hot plate test (a model of acute pain) and the spinal cord injury (a model of central pain) in mice and using A1 receptor antagonist (DPCPX) and A2A receptor antagonist (ZM241385); behaviors were scored and signal molecules such as reactive oxygen species and adenosine triphosphate levels and mitogen-activated protein kinases/extracellular signal-regulated protein kinase expression were measured...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28745101/acidosis-counteracts-itch-tachyphylaxis-to-consecutive-pruritogen-exposure-dependent-on-acid-sensing-ion-channel-3
#9
Yi-Ming Jiang, Chen Huang, Zhong Peng, Shao-Ling Han, Wei-Guang Li, Michael Xi Zhu, Tian-Le Xu
Tachyphylaxis of itch refers to a markedly reduced scratching response to consecutive exposures of a pruritogen, a process thought to protect against tissue damage by incessant scratching and to become disrupted in chronic itch. Here, we report that a strong stimulation of the Mas-related G-protein-coupled receptor C11 by its agonist, Ser-Leu-Ile-Gly-Arg-Leu-NH2 (SL-NH2) or bovine adrenal medulla 8-22 peptide, via subcutaneous injection in mice induces tachyphylaxis to the subsequent application of SL-NH2 to the same site...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28741447/-express-single-nucleotide-polymorphism-in-the-col11a2-gene-associated-with-heat-pain-sensitivity-in-knee-osteoarthritis
#10
Kwo Wei David Ho, Margaret R Wallace, Kimberly T Sibille, Emily J Bartley, Yenisel Cruz-Almeida, Toni L Glover, Christopher D King, Burel R Goodin, Adriana Addison, Jeffrey C Edberg, Roland Staud, Laurence A Bradley, Roger B Fillingim
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28741433/-express-immune-system-involvement-in-specific-pain-conditions
#11
Stacie K Totsch, Robert Ernest Sorge
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28741432/-express-identification-of-interleukin-1-beta-as-a-key-mediator-in-the-upregulation-of-cav3-2-usp5-interactions-in-the-pain-pathway
#12
Patrick L Stemkowski, Agustin Garcia-Caballero, Vinicius M Gadotti, Said M'Dahoma, Lina Chen, Ivana A Souza, Gerald W Zamponi
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28741431/-express-topical-moringin-cream-relieves-neuropathic-pain-by-suppression-of-inflammatory-pathway-and-voltage-gated-ion-channels-in-murine-model-of-multiple-sclerosis
#13
Sabrina Giacoppo, Renato Iori, Placido Bramanti, Emanuela Mazzon
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28741430/-express-orofacial-neuropathic-pain-induced-by-oxaliplatin-downregulation-of-kcnq2-channels-in-v2-trigeminal-ganglion-neurons-and-treatment-by-the-kcnq2-channel-potentiator-retigabine
#14
Jennifer Ling, Ferhat Erol, Viacheslav Viatchenko-Karpinski, Hirosato Kanda, Jianguo G Gu
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28741410/how-can-precision-medicine-be-applied-to-temporomandibular-disorders-and-its-comorbidities
#15
Joan B Wilentz, Allen W Cowley
The Eighth Scientific Meeting of The TMJ Association, Ltd. was held in Bethesda, Maryland, September 11-13, 2016. As in the past, the meeting was cosponsored by components of the National Institutes of Health with speakers invited to review the state of temporomandibular disorder science and propose recommendations to further progress. The theme of precision medicine, which aims to tailor disease treatment and prevention to match the characteristics of an individual patient (genetic, epigenetic, environmental, lifestyle) underscored the current consensus that temporomandibular disorders are no longer viewed as local conditions of jaw pain and dysfunction...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28726541/characterization-of-postsynaptic-calcium-signals-in-the-pyramidal-neurons-of-anterior-cingulate-cortex
#16
Xu-Hui Li, Qian Song, Tao Chen, Min Zhuo
Calcium signaling is critical for synaptic transmission and plasticity. N-methyl-D-aspartic acid (NMDA) receptors play a key role in synaptic potentiation in the anterior cingulate cortex. Most previous studies of calcium signaling focus on hippocampal neurons, little is known about the activity-induced calcium signals in the anterior cingulate cortex. In the present study, we show that NMDA receptor-mediated postsynaptic calcium signals induced by different synaptic stimulation in anterior cingulate cortex pyramidal neurons...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28726540/mechanisms-of-the-analgesic-effect-of-calcitonin-on-chronic-pain-by-alteration-of-receptor-or-channel-expression
#17
Akitoshi Ito, Megumu Yoshimura
The polypeptide hormone calcitonin is well known clinically for its ability to relieve osteoporotic back pain and neuropathic pain such as spinal canal stenosis, diabetic neuropathy, chemotherapy-induced neuropathy, and complex regional pain syndrome. Because the analgesic effects of calcitonin have a broad range, the underlying mechanisms of pain relief by calcitonin are largely unknown. However, recent studies using several types of chronic pain models combined with various methods have been gradually clarifying the mechanism...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28714352/-express-enhancement-of-spinal-dorsal-horn-neuron-nmda-receptor-phosphorylation-as-the-mechanism-of-remifentanil-induced-hyperalgesia-roles-of-pkc-and-camkii
#18
Sisi Li, Jie Zeng, Xiaoxiao Wan, Ying Yao, Nan Zhao, Yujia Yu, Cong Yu, Zhengyuan Xia
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28714351/activation-of-nlrp3-inflammasome-in-peripheral-nerve-contributes-to-paclitaxel-induced-neuropathic-pain
#19
Min Jia, Caihua Wu, Fang Gao, Hongchun Xiang, Ning Sun, Ping Peng, Jingjing Li, Xiaocui Yuan, Hongping Li, Xianfang Meng, Bo Tian, Jing Shi, Man Li
Background Paclitaxel is commonly used as a cancer chemotherapy drug that frequently causes peripheral neuropathic pain. Inflammasome is a multiprotein complex consisting of Nod-like receptor proteins (NLRPs), apoptosis-associated speck-like protein, and caspase-1, which functions to switch on the inflammatory process and the release of interleukin-1β. Growing evidences have supported that peripheral interleukin-1β is critical in enhancing paclitaxel-induced neuropathic pain. However, whether activation of NLRP3 inflammasome in peripheral nerve contributes to paclitaxel-induced neuropathic pain is still unclear...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28714350/activation-and-expression-of-%C3%AE-calpain-in-dorsal-root-contributes-to-rtx-induced-mechanical-allodynia
#20
Xiao-Cui Yuan, Cai-Hua Wu, Fang Gao, Hong-Ping Li, Hong-Chun Xiang, He Zhu, Xiao-Li Pan, Li-Xue Lin, Yan-Shen Liu, Wei Yu, Bo Tian, Xian-Fang Meng, Man Li
Background Calpain is a calcium-dependent cysteine protease, and inhibition of calpain by pre-treatment with MDL28170 attenuated the rat mechanical allodynia in a variety of pain models. Postherpetic neuralgia (Shingles) is a neuropathic pain conditioned with the presence of profound mechanical allodynia. Systemic injection of resiniferatoxin can reproduce the clinical symptoms of postherpetic neuralgia. In this study, we determined to study whether activation of calpain contributes to cleave the myelin basic protein of dorsal root and is involved in resiniferatoxin-induced mechanical allodynia of postherpetic neuralgia animal model...
January 2017: Molecular Pain
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