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Molecular Pain

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https://www.readbyqxmd.com/read/28633557/-express-cxcl12-cxcr4-signaling-mediated-erk1-2-activation-in-spinal-cord-contributes-to-the-pathogenesis-of-postsurgical-pain-in-rats
#1
Fei Xing, Cunlong Kong, Liying Bai, Junliang Qian, Jingjing Yuan, Zhisong Li, Wei Zhang, Ji-Tian Xu
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28604222/-express-primary-sensory-neuron-specific-interference-of-trpv1-signaling-by-aav-encoded-trpv1-peptide-aptamer-attenuates-neuropathic-pain
#2
Hongfei Xiang, Zhen Liu, Fei Wang, Hao Xu, Christopher Roberts, Gregory Fischer, Cheryl Stucky, Dean Caron, Bin Pan, Quinn Hogan, Hongwei Yu
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28604221/-express-slack-kna-channels-influence-dorsal-horn-synapses-and-nociceptive-behavior
#3
Katherine M Evely, Kerri D Pryce, Anne E Bausch, Robert Lukowski, Peter Ruth, Samir Haj-Dahmane, Arin Bhattacharjee
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28604220/-express-peripheral-inflammatory-injury-alters-the-relative-abundance-of-g%C3%AE-subunits-in-the-dorsal-horn-of-the-spinal-cord-and-in-the-rostral-ventromedial-medulla-of-male-rats
#4
Anne-Sophie Wattiez, Roxanne Y Walder, Christopher M Sande, Stephanie R White, Donna L Hammond
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28604219/potentiation-of-nmda-receptor-mediated-synaptic-transmission-at-the-parabrachial-central-amygdala-synapses-by-cgrp-in-mice
#5
Yuya Okutsu, Yukari Takahashi, Masashi Nagase, Kei Shinohara, Ryo Ikeda, Fusao Kato
The capsular part of the central amygdala (CeC) is called the "nociceptive amygdala," as it receives nociceptive information from various pathways, including monosynaptic input from the lateral part of the parabrachial nucleus (LPB), a major target of ascending neurons in the spinal and medullary dorsal horn. LPB-CeC synaptic transmission is mediated by glutamate but the fibers from the LPB also contain calcitonin gene-related peptide (CGRP) and the CeC is rich in CGRP-binding sites. CGRP might be released in response to strong nociception and activate these CGRP receptors...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28587509/-express-differential-involvement-of-reactive-oxygen-species-in-a-mouse-model-of-capsaicin-induced-secondary-mechanical-hyperalgesia-and-allodynia
#6
Jun-Ho La, Jigong Wang, Alice Bittar, Hyun Soo Shim, Chilman Bae, Jin Mo Chung
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28587505/chronic-cervical-radiculopathic-pain-is-associated-with-increased-excitability-and-hyperpolarization-activated-current-ih-in-large-diameter-dorsal-root-ganglion-neurons
#7
Da-Lu Liu, Xu Wang, Wen-Guang Chu, Na Lu, Wen-Juan Han, Yi-Kang Du, San-Jue Hu, Zhan-Tao Bai, Sheng-Xi Wu, Rou-Gang Xie, Ceng Luo
Cervical radiculopathic pain is a very common symptom that may occur with cervical spondylosis. Mechanical allodynia is often associated with cervical radiculopathic pain and is inadequately treated with current therapies. However, the precise mechanisms underlying cervical radiculopathic pain-associated mechanical allodynia have remained elusive. Compelling evidence from animal models suggests a role of large-diameter dorsal root ganglion neurons and plasticity of spinal circuitry attached with Aβ fibers in mediating neuropathic pain...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28587499/loss-in-translation
#8
Min Zhuo, Jiangguo Gu
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28580839/-express-epac-and-nociceptor-sensitization
#9
Li-Yen Huang, Yanping Gu
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28580836/-express-ion-channels-and-neuronal-hyperexcitability-in-chemotherapy-induced-peripheral-neuropathy-cause-and-effect
#10
Kelly Ann Aromolaran, Peter A Goldstein
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28580829/-express-molecular-cellular-and-behavioral-changes-associated-with-pathological-pain-signaling-occur-after-dental-pulp-injury
#11
Caroline Lee, Austin Ramsey, Helaine De Brito-Gariepy, Benoit Michot, Eugene Podborits, Janet Melnyk, Jennifer Lynn Gibbs
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28580822/effects-of-microrna-223-on-morphine-analgesic-tolerance-by-targeting-nlrp3-in-a-rat-model-of-neuropathic-pain
#12
Xiao-Juan Xie, Li-Gang Ma, Kai Xi, Dong-Mei Fan, Jian-Guo Li, Quan Zhang, Wei Zhang
Objective To investigate the effects of microRNA-223 on morphine analgesic tolerance by targeting NLRP3 in a rat model of neuropathic pain. Methods Our study selected 100 clean grade healthy Sprague-Dawley adult male rats weighing 200 to 250 g. After establishment of a rat model of chronic constriction injury, these rats were divided into 10 groups (10 rats in each group): the normal control, sham operation, chronic constriction injury, normal saline, morphine, miR-223, NLRP3, miR-223 + morphine, NLRP3 + morphine, and miR-223 + NLRP3 + morphine groups...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28580811/-express-the-effects-of-hyperbaric-oxygen-therapy-on-neuropathic-pain-via-mitophagy-in-microglia
#13
Guang Han, Kun Liu, Lu Li, Xingyue Li, Ping Zhao
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28566000/peripheral-kv7-channels-regulate-visceral-sensory-function-in-mouse-and-human-colon
#14
Madusha Peiris, James Rf Hockley, David E Reed, Ewan St John Smith, David C Bulmer, L Ashley Blackshaw
Background Chronic visceral pain is a defining symptom of many gastrointestinal disorders. The KV7 family (KV7.1-KV7.5) of voltage-gated potassium channels mediates the M current that regulates excitability in peripheral sensory nociceptors and central pain pathways. Here, we use a combination of immunohistochemistry, gut-nerve electrophysiological recordings in both mouse and human tissues, and single-cell qualitative real-time polymerase chain reaction of gut-projecting sensory neurons, to investigate the contribution of peripheral KV7 channels to visceral nociception...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28565999/ryk-receptors-on-unmyelinated-nerve-fibers-mediate-excitatory-synaptic-transmission-and-ccl2-release-during-neuropathic-pain-induced-by-peripheral-nerve-injury
#15
Qing Ou Yang, Wen-Jing Yang, Jian Li, Fang-Ting Liu, Hongbin Yuan, Yue-Ping Ou Yang
Background Neuropathic pain is a major pathology of the central nervous system associated with neuroinflammation. Ryk (receptor-like tyrosine kinase) receptors act as repulsive axon-guidance molecules during development of central nervous system and neural injury. Increasing evidence suggests the potential involvement of Wnt/Ryk (wingless and Int) signaling in the pathogenesis of neuropathic pain. However, its underlying mechanism remains unknown. Results The expression and location of Ryk receptor as well as its ligand Wnt1 were detected by qPCR, Western blot, and immunohistochemistry...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28565998/gabab-receptors-mediated-tonic-inhibition-of-glutamate-release-from-a%C3%AE-fibers-in-rat-laminae-iii-iv-of-the-spinal-cord-dorsal-horn
#16
Chiara Salio, Adalberto Merighi, Rita Bardoni
Presynaptic GABAB receptors (GABABRs) are highly expressed in dorsal root ganglion neurons and spinal cord dorsal horn. GABABRs located in superficial dorsal horn play an important antinociceptive role, by acting at both pre- and postsynaptic sites. GABABRs expressed in deep dorsal horn could be involved in the processing of touch sensation and possibly in the generation of tactile allodynia in chronic pain. The objective of this study was to characterize the morphological and functional properties of GABABRs expressed on Aβ fibers projecting to lamina III/IV and to understand their role in modulating excitatory synaptic transmission...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28554250/resveratrol-decreased-hyperalgesia-mediated-by-the-p2x7-receptor-in-gp120-treated-rats
#17
Bing Wu, Yucheng Ma, Zhihua Yi, Shuangmei Liu, Shenqiang Rao, Lifang Zou, Shouyu Wang, Yun Xue, Tianyu Jia, Shanhong Zhao, Liran Shi, Lin Li, Huilong Yuan, Shangdong Liang
Background Chronic pain is a common symptom in human immunodeficiency virus (HIV)-1 infection/acquired immunodeficiency syndrome patients. The literature shows that the HIV envelope glycoprotein 120 (gp120) can directly cause hyperalgesia by stimulating primary sensory afferent nerves. The P2X7 receptor in the dorsal root ganglia (DRG) is closely related to neuropathic and inflammatory pain. In this study, we aimed to explore the effect of resveratrol (RES) on gp120-induced neuropathic pain that is mediated by the P2X7 receptor in the rat DRG...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28554249/suppression-of-asparaginyl-endopeptidase-attenuates-breast-cancer-induced-bone-pain-through-inhibition-of-neurotrophin-receptors
#18
Peng Yao, Yuanyuan Ding, Zhenkai Han, Ying Mu, Tao Hong, Yongqiang Zhu, Hongxi Li
Objective Cancer-induced bone pain is a common clinical problem in breast cancer patients with bone metastasis. However, the mechanisms driving cancer-induced bone pain are poorly known. Recent studies show that a novel protease, asparaginyl endopeptidase (AEP) plays crucial roles in breast cancer metastasis and progression. We aim to determine the functions and targeted suppress of AEP in a mouse model of breast cancer-induced bone pain. Methods Breast cancer cells with AEP knocked-down or overexpression were constructed and implanted into the intramedullary space of the femur to induce pain-like behavior in mice...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28486009/correction-notice
#19
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28480796/-express-microrna-9-regulates-mammalian-axon-regeneration-in-peripheral-nerve-injury
#20
Jingjing Jiang, Yiwen Hu, Boyin Zhang, Yao Shi, Jin Zhang, Xiuying Wu, Peng Yao
No abstract text is available yet for this article.
January 2017: Molecular Pain
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