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Clinical Toxicology

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https://www.readbyqxmd.com/read/28994311/death-associated-with-intravenous-turmeric-curcumin-preparation
#1
Daniel R Lasoff, Frank Lee Cantrell, Binh T Ly
No abstract text is available yet for this article.
October 10, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28992737/asenapine-iloperidone-and-lurasidone-exposures-in-young-children-reported-to-u-s-poison-centers
#2
Gina Stassinos, Wendy Klein-Schwartz
CONTEXT: Asenapine, iloperidone and lurasidone are relatively new atypical antipsychotics. There is limited information on toxicity on pediatric exposures to these drugs. The objective of this study was to compare toxicity associated with asenapine, iloperidone and lurasidone exposures in young children. METHODS: A retrospective study of U.S. National Poison Data System from 2010 to 2015 of single substance exposures to asenapine, iloperidone or lurasidone in children <6 years of age that were followed to known outcome was performed...
October 10, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28988498/2-methyl-4-chlorophenoxyacetic-acid-mcpa-and-bromoxynil-herbicide-ingestion
#3
Angela L Chiew, Colin B Page, David Clancy, Ahmed Mostafa, Michael S Roberts, Geoffrey K Isbister
CONTEXT: Ingestion of bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) in combination is associated with high mortality. Toxicity is characterised by hyperthermia and metabolic acidosis. Dialysis is a proposed treatment, but little data exist regarding its effectiveness. CASE DETAILS: Case 1: A 50-year-old female presented 18 h post-ingestion of 200  mL of bromoxynil(200 g/L) and MCPA(200 g/L). She was agitated, tachycardic and tachypnoeic. She was intubated and continuous venovenous haemodiafiltration (CVVHDF) was commenced...
October 9, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28980497/the-clinical-effects-of-the-venomous-lessepsian-migrant-fish-plotosus-lineatus-thunberg-1787-in-the-southeastern-mediterranean-sea
#4
Yedidia Bentur, Sergey Altunin, Iris Levdov, Daniel Golani, Ehud Spanier, Dor Edelist, Yael Lurie
CONTEXT: Plotosus lineatus is a venomous fish that has migrated from the Indo-Pacific region to the Mediterranean Sea (Lessepsian migrant). Its presence in the Mediterranean Sea was first recorded in 2002 and was observed in growing schools. Its spines contain toxins with lytic, hemolytic and edematous activities. OBJECTIVE: To characterize the injuries caused by Plotosus lineatus in the Southeastern Mediterranean Sea. METHODS: A prospective observational case series of consultations provided by a national Poison Center pertaining to Plotosus lineatus from 2007 to 2016...
October 5, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28969436/acquired-methemoglobinemia-after-hydroxocobalamin-administration-in-a-patient-with-burns-and-inhalation-injury
#5
Alisha Z Jiwani, Vikhyat S Bebarta, Leopoldo C Cancio
CONTEXT: Hydroxocobalamin is an effective cyanide antidote. While erythema, hypertension, and chromaturia are recognized side effects, methemoglobinemia has not been reported. Methemoglobin levels are most accurately measured by co-oximetry. We describe an extensively burned patient who developed methemoglobinemia within an hour of hydroxocobalamin administration. CASE DETAILS: A 47-year old man without genetic deficiencies or abnormal hemoglobin variants presented with 61% body surface area thermal burns and grade 1 inhalation injury sustained during a tugboat engine explosion...
October 3, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28944701/in-response-to-are-changes-necessary-in-the-medical-management-of-a-patient-with-snakebite-regarding-the-incidence-of-hypersensitivity-reaction-to-antivenom-polyvalent-immune-fab
#6
Justin Rizer, Joshua King, Nathan Charlton
No abstract text is available yet for this article.
September 25, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28944696/suicidal-bupropion-ingestions-in-adolescents-increased-morbidity-compared-with-other-antidepressants
#7
David C Sheridan, Amber Lin, B Zane Horowitz
OBJECTIVE: Bupropion is often categorized as a newer generation antidepressant and assessed with serotonin reuptake inhibitors as a lower risk than older tricyclic antidepressants (TCAs). The objective of this study was to compare outcomes in adolescent suicide from ingestions between bupropion and TCA medications. STUDY DESIGN: An analysis of the National Poison Data System for exposures coded "suspected suicide" in adolescents (age: 13-19) was undertaken for the years 2013-2016 and included TCAs or bupropion...
September 25, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28938866/the-interpretation-of-hair-analysis-for-drugs-and-drug-metabolites
#8
Eva Cuypers, Robert J Flanagan
INTRODUCTION: Head hair analysis for drugs and drug metabolites has been used widely with the aim of detecting exposure in the weeks or months prior to sample collection. However, inappropriate interpretation of results has likely led to serious miscarriages of justice, especially in child custody cases. OBJECTIVE: The aim of this review is to assess critically what can, and perhaps more importantly, what cannot be claimed as regards the interpretation of hair test results in a given set of circumstances in order to inform future testing...
September 22, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28929811/addendum-to-mogle-et-al-severe-neutrophilic-dermatosis-following-submental-deoxycholic-acid-administration
#9
(no author information available yet)
No abstract text is available yet for this article.
September 20, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28922956/dmts-is-an-effective-treatment-in-both-inhalation-and-injection-models-for-cyanide-poisoning-using-unanesthetized-mice
#10
Susan M DeLeon, Jason D Downey, Diane M Hildenberger, Melissa O Rhoomes, Lamont Booker, Gary A Rockwood, Kelly A Basi
CONTEXT: Cyanide (CN) is a metabolic poison, halting ATP synthesis by inhibiting complex IV of the electron transport chain. If exposed at high enough concentrations, humans and most animals can die within minutes. Because time is a crucial factor in survival of CN poisoning, a rapidly bioavailable, nontoxic, easy to administer CN medical countermeasure could improve morbidity/mortality in a mass CN exposure scenario. The most likely route of exposure to CN is via inhalation. OBJECTIVE: This study examined the efficacy of a new formulation for dimethyl trisulfide (DMTS), a countermeasure which has shown promise as a treatment for CN poisoning, using both inhalation and injection models of CN exposure...
September 19, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28922939/polyneuropathy-following-acute-fenitrothion-poisoning
#11
Jung Taek Park, Kyoung Ho Choi
No abstract text is available yet for this article.
September 19, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28906147/carbon-monoxide-poisoning-from-waterpipe-smoking-a-retrospective-cohort-study
#12
Lars Eichhorn, Dirk Michaelis, Michael Kemmerer, Björn Jüttner, Kay Tetzlaff
OBJECTIVE: Waterpipe smoking may increasingly account for unintentional carbon monoxide poisoning, a serious health hazard with high morbidity and mortality. We aimed at identifying waterpipe smoking as a cause for carbon monoxide poisoning in a large critical care database of a specialty care referral center. METHODS: This retrospective cohort study included patients with a history of exposure to waterpipe smoking and carbon monoxide blood gas levels >10% or presence of clinical symptoms compatible with CO poisoning admitted between January 2013 and December 2016...
September 14, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28905656/comparison-of-low-dose-and-standard-dose-abdominal-ct-scan-in-body-stuffers
#13
Hooman Bahrami-Motlagh, Zahra Mahboubi-Fooladi, Babak Salevatipour, Hossein Hassanian-Moghaddam, Seyyed Hadi Mirhashemi
PURPOSE: Detection of body stuffers is challenging in emergency departments. Because of the small size of baggies, plain radiograph is of little value in most suspects. On the other hand, abdomen CT scan is burdened by high cost and radiation dose. This study was performed to compare the image quality, radiation dose and accuracy of low-dose CT scan in comparison with standard dose. MATERIAL AND METHODS: In this prospective study, suspected body stuffers who were referred to the radiology department underwent two different protocols of abdominal non-contrast CT scan simultaneously: low-dose (with equivalent dose to conventional abdominal x-ray) and standard dose...
September 14, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28905655/inverted-takotsubo-syndrome-in-androctonus-australis-scorpion-envenomation
#14
Fekri Abroug, Islem Ouanes, Mezri Maatouk, Mondher Golli, Lamia Ouanes-Besbes
CONTEXT: The nature of scorpion-related cardiomyopathy is still a matter of debate where specific toxin-induced cardiomyopathy, ischemic, or catecholaminergic cardiomyopathy is advocated as well. We report two cases of Takotsubo syndrome following envenomation by Androctonus australis, bringing new evidence for the fundamental role of catecholamines in the pathogenesis of this cardiomyopathy. Case 1: A woman aged 36 presented with pulmonary edema and shock following scorpion envenomation...
September 14, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28905654/opsoclonus-myoclonus-syndrome-following-long-term-use-of-cyclosporine
#15
Hyun Goo Kang, Sung Kwang Park, Su Jeong Wang, Sun-Young Oh, Han Uk Ryu
BACKGROUND: Cyclosporine A (CsA) is a widely used immunosuppressive agent that may provoke unexpected neurologic complications. The mechanism is unclear and variable intervals have been reported between CsA administration and onset of the related side effects. Here, we describe a case of delayed-onset CsA neurotoxicity presenting as opsoclonus-myoclonus syndrome (OMS). CASE DETAILS: A 37-year-old woman with a two-week period of opsoclonus and upper extremity myoclonus was admitted to our hospital...
September 14, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28895757/intoxications-in-the-strida-project-involving-a-panorama-of-psychostimulant-pyrovalerone-derivatives-mdpv-copycats
#16
Olof Beck, Matilda Bäckberg, Patrick Signell, Anders Helander
CONTEXT: An increasing number of new psychoactive substances (NPS) of different chemical classes have become available through marketing and sale over the Internet. This report from the Swedish STRIDA project presents the prevalence, laboratory results, and clinical features in intoxications involving 11 stimulant pyrovalerone NPS derivatives over a 5-year period. STUDY DESIGN: Case series of consecutive patients with admitted or suspected intake of NPS presenting to Swedish hospitals for emergency treatment from January 2011 to March 2016...
September 12, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28885114/clinical-predictors-of-tissue-necrosis-following-rattlesnake-envenomation
#17
C William Heise, Anne-Michelle Ruha, Angela Padilla-Jones, Carrie Truitt Hayek, Richard D Gerkin
BACKGROUND: Rattlesnake envenomation (RSE) causes edema, hemotoxicity and tissue necrosis. Necrosis may result in permanent disability. OBJECTIVE: To study patient-related factors associated with tissue necrosis after Crotalus envenomation. METHODS: Prospective cohort study of patients admitted to the Medical Toxicology service with diagnosis of RSE between April 2011 and November 2014. Inclusion criteria were age ≥18 years and upper extremity (UE) envenomation site...
September 8, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28874088/focusing-solely-on-the-effect-of-the-medication-without-taking-a-holistic-view-of-the-patient-does-not-seem-very-constructive
#18
Nicolas Franchitto, Luc De Haro, Fanny Pélissier
No abstract text is available yet for this article.
September 5, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28872357/acmt-and-aact-position-statement-preventing-occupational-fentanyl-and-fentanyl-analog-exposure-to-emergency-responders
#19
Michael J Moss, Brandon J Warrick, Lewis S Nelson, Charles A McKay, Pierre-André Dubé, Sophie Gosselin, Robert B Palmer, Andrew I Stolbach
No abstract text is available yet for this article.
September 5, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28871821/centruroides-sculpturatus-envenomation-in-three-adult-patients-requiring-treatment-with-antivenom
#20
Nicholas B Hurst, Demis N Lipe, Stephen R Karpen, Asad E Patanwala, Ann M Taylor, Keith J Boesen, F Mazda Shirazi
CONTEXT: Envenomation by Centruroides sculpturatus can manifest with cranial nerve dysfunction and neuromuscular hyperactivity. While these symptoms are most commonly seen in young children, they may also be seen in adults. CASE DETAILS: Three cases of adult patients are presented with grades III & IV scorpion envenomation. They reported symptoms including disconjugate, roving eye movements, and motor involvement. Also reported were hyposmia, difficulty with fine motor movements, and dysgeusia...
September 5, 2017: Clinical Toxicology
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