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Clinical Toxicology

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https://www.readbyqxmd.com/read/28301275/serum-s100-protein-could-predict-altered-consciousness-in-glyphosate-or-glufosinate-poisoning-patients
#1
Jung-Won Lee, Young-Jin Choi, Samel Park, Hyo-Wook Gil, Ho-Yeon Song, Sae-Yong Hong
BACKGROUND: Central nervous system (CNS) complications such as seizures and reduced consciousness are important in glufosinate and may occur in severe glyphosate poisoning. The aim of this study was to assess the possible role of serum S100B protein as a biochemical marker of CNS complications associated with glyphosate or glufosinate poisoning. METHODS: The study enrolled 40 patients (23 glyphosate poisoning and 17 glufosinate poisoning). Altered consciousness and seizure were observed during hospitalization...
March 16, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28277803/a-systematic-review-of-the-evidence-for-acute-tolerance-to-alcohol-the-mellanby-effect
#2
Michael G Holland, Robin E Ferner
OBJECTIVE: To review the evidence for "the Mellanby effect", that is, whether the response to a given blood alcohol concentration (BAC) is more marked when BAC is rising than at the same concentration when BAC is falling. METHODS: We systematically searched the databases EMBASE, Medline, and Scopus up to and including December 2016 using text words "tolerance", "ascending", "descending" or "Mellanby" with Medline term "exp *alcohol/" or "exp *drinking behavior/" or equivalent...
March 9, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28165801/use-of-polyvalent-equine-anti-viper-serum-to-treat-delayed-coagulopathy-due-to-suspected-sistrurus-miliarius-streckeri-envenomation-in-two-children
#3
Kristie L Williams, Megan Woslager, Stephanie L Garland, Roger P Barton, William Banner
BACKGROUND: Western Pygmy Rattlesnake (WPR) envenomation reportedly causes refractory and persistent coagulopathy when treated with CroFab(®) (Crotalidae Polyvalent Immune Fab). We report two cases where polyvalent equine anti-viper serum (AntivipmynTRI(®)) was used to treat recurrent coagulopathy in children. CASE DETAILS: The first patient was a 16-month-old male who was bitten by a confirmed WPR. The patient received a total of 18 vials of CroFab(®). His labs normalized, swelling gradually improved, and the child was discharged to home...
February 6, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28165800/rising-cost-of-antidotes-in-the-u-s-cost-comparison-from-2010-to-2015
#4
Gregory A Heindel, Jeanette D Trella, Kevin C Osterhoudt
CONTEXT: Our poison control center observed a large increase in the cost of many antidotes over the past several years. The high cost of antidotes has previously been cited as a factor leading to inadequate antidote supply at some hospitals. Continued increases in the cost of antidotes may lead to further reductions in antidote supply and represent serious concerns. This research aims to quantify recent trends in the costs of antidotes in the U.S. METHODS: Antidotes and minimum stocking recommendations were retrieved from published guidelines...
February 6, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28084844/poison-exposures-in-young-israeli-military-personnel-a-national-poison-center-data-analysis
#5
Ophir Lavon, Yedidia Bentur
CONTEXT: To characterize poison exposures in young Israeli military personnel as reported to the national poison center. METHODS: Retrospective poison center chart review over a 14-year period. Cases included were Israeli soldiers aged 18-21 years, the compulsory military service age required by the Israeli law. RESULTS: 1770 records of poison exposures in young military personnel were identified. Most exposed individuals involved males (n = 1268, 71...
January 13, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28206825/letter-in-response-to-efficiency-of-acidemia-correction-on-intermittent-versus-continuous-hemodialysis-in-acute-methanol-poisoning
#6
Lindsay M Fox, Mark K Su, Lewis R Goldfrank
No abstract text is available yet for this article.
April 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28206824/reply-to-letter-in-response-to-efficiency-of-acidemia-correction-on-intermittent-versus-continuous-hemodialysis-in-acute-methanol-poisoning
#7
Sergey Zakharov, Darren M Roberts, Knut Erik Hovda
No abstract text is available yet for this article.
April 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28165820/leukotriene-mediated-neuroinflammation-toxic-brain-damage-and-neurodegeneration-in-acute-methanol-poisoning
#8
Sergey Zakharov, Katerina Kotikova, Olga Nurieva, Jiri Hlusicka, Petr Kacer, Pavel Urban, Manuela Vaneckova, Zdenek Seidl, Pavel Diblik, Pavel Kuthan, Tomas Navratil, Daniela Pelclova
CONTEXT: The role of neuroinflammation in methanol-induced toxic brain damage has not been studied. OBJECTIVE: We studied acute concentrations and the dynamics of leukotrienes (LT) in serum in hospitalized patients with acute methanol poisoning and in survivors. METHODS: Series of acute cysteinyl-LT and LTB4 concentration measurements were performed in 28/101 hospitalized patients (mean observation time: 88 ± 20 h). In 36 survivors, control LT measurements were performed 2 years after discharge...
April 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28152639/the-authors-reply-regarding-do-heroin-overdose-patients-require-observation-after-receiving-naloxone
#9
Michael W Willman, David B Liss, Evan S Schwarz, Michael E Mullins
No abstract text is available yet for this article.
April 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28152638/are-vasopressors-useful-in-toxin-induced-cardiogenic-shock
#10
REVIEW
Cassandra A Skoog, Kristin M Engebretsen
OBJECTIVE: Overdoses with cardio-depressive medications can result in toxin-induced cardiogenic shock (TICS), a life-threatening condition characterized by severe hypotension and ineffective tissue perfusion. Vasopressors are often employed in the treatment of shock to increase heart rate and blood pressure. We sought to conduct a systematic review of the literature to evaluate the effectiveness of vasopressors in improving hemodynamic function and survival in the treatment of TICS. DATA SOURCES: We searched PubMed, EMBASE, TOXLINE, and International Pharmaceutical Abstracts...
April 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28152637/l-arginine-in-the-treatment-of-valproate-overdose-five-clinical-cases
#11
Verena Schrettl, Norbert Felgenhauer, Christian Rabe, Malkanthi Fernando, Florian Eyer
BACKGROUND: Valproic acid and its metabolites - particularly valproyl-CoA - are inhibitors of the enzyme N-acetylglutamate synthetase. The amino acid l-arginine can stimulate N-acetylglutamate synthetase activity and could be potentially used therapeutically to correct hyperammonemia caused by valproate therapy or overdose. Severely valproic-acid-poisoned patients are usually treated with l-carnitine or hemodialysis in order to decrease hyperammonemia. We herein report of five cases, in which l-arginine was administered...
April 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28152635/self-poisoning-with-baclofen-in-alcohol-dependent-patients-national-reports-to-french-poison-control-centers-2008-2013
#12
MULTICENTER STUDY
Fanny Pelissier, Luc de Haro, Florence Cardona, Cyndie Picot, Emmanuel Puskarczyk, Jean-Marc Sapori, Christine Tournoud, Nicolas Franchitto
BACKGROUND: Alcohol use disorders are frequently associated with self-intoxication in attempted suicide. In France since 2008, the off-label use of baclofen for treatment of alcohol dependence has greatly increased, leading to temporary regulation of use of the drug. At the request of the national authorities, the French Poison Control Centers carried out a retrospective survey to give an overview of baclofen exposure in this population. METHODS: A retrospective study was carried out from January 2008 to December 2013, focusing on baclofen exposures in alcohol-dependent patients managed by the nine national French Poison Control Centers...
April 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28152633/long-term-mortality-after-poisoning-with-antipsychotics
#13
Stine Toft, Henrik Horwitz, Kim Peder Dalhoff
INTRODUCTION: The objective of this study was to investigate the long-term mortality and cause of death after deliberate self-poisoning with antipsychotics. Furthermore, we investigated the risk of repeated self-poisoning after a first episode of poisoning with antipsychotics. METHODS: We identified patients with antipsychotic poisoning from the Danish Poison Information Centre Database and correlated their personal identification number with four Danish national registries related to health aspects...
April 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28140683/in-response-to-do-heroin-overdose-patients-require-observation-after-receiving-naloxone
#14
William Eggleston, Brian M Clemency
No abstract text is available yet for this article.
April 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28103732/evaluation-of-antivenom-therapy-for-vipera-palaestinae-bites-in-children-experience-of-two-large-tertiary-care-pediatric-hospitals
#15
Dikla Pivko-Levy, Itamar Munchnak, Ayelet Rimon, Uri Balla, Dennis Scolnik, Christopher Hoyte, Yair Voliovitch, Miguel Glatstein
BACKGROUND: Antivenom has been successfully used to treat systemic and progressive, local manifestations of envenomation inflicted by Vipera (V.) palaestinae, the most common venomous snake in Israel. The objective of this study was to evaluate the fixed dose V. palaestinae monovalent (equine) immunoglobulin G antivenom used in two pediatric emergency departments. In particular, we wanted to assess the need for repeated antivenom administration and the rate of adverse antivenom effects in children...
April 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28092984/vipera-ammodytes-bites-treated-with-antivenom-viperatab-a-case-series-with-pharmacokinetic-evaluation
#16
Miran Brvar, Tihana Kurtović, Damjan Grenc, Maja Lang Balija, Igor Križaj, Beata Halassy
CONTEXT: In clinical practice it is difficult to differentiate between V. berus and V. ammodytes venomous bites. In the past this was not a concern, but due to the current shortage in Viperfav™ and European viper venom antiserum availability, V. a. ammodytes venomous bites have recently been treated with ViperaTAb(®), which is a pharmaceutical formulation containing a monospecific ovine Fab fragments against the venom of V. berus. OBJECTIVE: To evaluate ViperaTAb(®) in V...
April 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28114828/rotational-thromboelastometry-rotem-guided-treatment-of-an-afghanistan-viper-envenomation-at-a-nato-military-hospital
#17
Paul J D Roszko, Michael J Kavanaugh, Martin L Boese, Jason J Longwell, Angela S Earley
No abstract text is available yet for this article.
March 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28114820/a-case-of-massive-methadone-overdose-presented-with-refractory-hypoglycemia
#18
Alex Tin Yan Li, Francis Kin Chiu Chu
No abstract text is available yet for this article.
March 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28107093/adult-clonidine-overdose-prolonged-bradycardia-and-central-nervous-system-depression-but-not-severe-toxicity
#19
Geoffrey K Isbister, Simon P Heppell, Colin B Page, Nicole M Ryan
CONTEXT: There are limited reports of adult clonidine overdose. We aimed to describe the clinical effects and treatment of clonidine overdose in adults. METHODS: This was a retrospective review of a prospective cohort of poisoned patients who took clonidine overdoses (>200 μg). Demographic information, clinical effects, treatment, complications (central nervous system and cardiovascular effects) and length of stay (LOS) were extracted from a clinical database or medical records...
March 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28084855/occupational-transdermal-poisoning-with-synthetic-cannabinoid-cumyl-pinaca
#20
Mojca Dobaja, Damjan Grenc, Gordana Kozelj, Miran Brvar
CONTEXT: Synthetic cannabinoids are getting more popular among young people and illicit manufacturers. We report a case series of occupational transdermal poisoning with synthetic cannabinoids. CASE DETAILS: Three customs inspectors got in contact with a sticky substance with their fingertips because they were not wearing protection gloves and the delivered package was damaged. Despite washing their hands with water, signs of synthetic cannabinoids intoxication started occurring half an hour after exposure...
March 2017: Clinical Toxicology
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