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Clinical Toxicology

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https://www.readbyqxmd.com/read/27921461/radical-7-co-oximeter-inaccuracies-reply
#1
Elspeth Hulse, Fathima Shihana, Nick A Buckley
No abstract text is available yet for this article.
December 6, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27921441/re-methemoglobin-measurements-are-underestimated-by-the-radical-7-co-oximeter-experience-from-a-series-of-moderate-to-severe-propanil-poisonings
#2
Nasim Zamani, Hossein Hassanian-Moghaddam
No abstract text is available yet for this article.
December 6, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27919185/modeling-the-effect-of-succimer-dmsa-dimercaptosuccinic-acid-chelation-therapy-in-patients-poisoned-by-lead
#3
Jan C H van Eijkeren, J Daniël N Olie, Sally M Bradberry, J Allister Vale, Irma de Vries, Harvey J Clewell, Jan Meulenbelt, Claudine C Hunault
CONTEXT: Kinetic models could assist clinicians potentially in managing cases of lead poisoning. Several models exist that can simulate lead kinetics but none of them can predict the effect of chelation in lead poisoning. Our aim was to devise a model to predict the effect of succimer (dimercaptosuccinic acid; DMSA) chelation therapy on blood lead concentrations. MATERIALS AND METHODS: We integrated a two-compartment kinetic succimer model into an existing PBPK lead model and produced a Chelation Lead Therapy (CLT) model...
December 5, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27903075/australian-taipan-oxyuranus-spp-envenoming-clinical-effects-and-potential-benefits-of-early-antivenom-therapy-australian-snakebite-project-asp-25
#4
Christopher I Johnston, Nicole M Ryan, Margaret A O'Leary, Simon G A Brown, Geoffrey K Isbister
CONTEXT: Taipans (Oxyuranus spp.) are medically important venomous snakes from Australia and Papua New Guinea. The objective of this study was to describe taipan envenoming in Australian and its response to antivenom. METHODS: Confirmed taipan bites were recruited from the Australian Snakebite Project. Data were collected prospectively on all snakebites, including patient demographics, bite circumstances, clinical effects, laboratory results, complications and treatment...
November 30, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27882778/traditional-medicine-preparations-and-health-risks-time-to-revisit-their-regulatory-status
#5
Eduardo Mello De Capitani
No abstract text is available yet for this article.
November 24, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27849133/do-heroin-overdose-patients-require-observation-after-receiving-naloxone
#6
Michael W Willman, David B Liss, Evan S Schwarz, Michael E Mullins
CONTEXT: Heroin use in the US has exploded in recent years, and heroin overdoses requiring naloxone are very common. After awakening, some heroin users refuse further treatment or transport to the hospital. These patients may be at risk for recurrent respiratory depression or pulmonary edema. In those transported to the emergency department, the duration of the observation period is controversial. Additionally, non-medical first responders and lay bystanders can administer naloxone for heroin and opioid overdoses...
November 16, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27824267/the-impact-of-online-toxicology-training-on-fijian-emergency-doctors-knowledge-the-global-educational-toxicology-uniting-project-getup
#7
A Wong, A Stolbach, A H Dawson, R Vohra
No abstract text is available yet for this article.
November 8, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27817225/efficiency-of-acidemia-correction-on-intermittent-versus-continuous-hemodialysis-in-acute-methanol-poisoning
#8
Sergey Zakharov, Daniela Pelclova, Tomas Navratil, Jaromir Belacek, Jiri Latta, Michal Pisar, Jan Rulisek, Jiri Leps, Pavel Zidek, Cyril Kucera, Robert Bocek, Miroslav Mazur, Zdenek Belik, Josef Chalupa, Viktor Talafa, Kamil Kodras, Daniel Nalos, Ctirad Sedlak, Michal Senkyrik, Jan Smid, Tomas Salek, Darren M Roberts, Knut Erik Hovda
CONTEXT: Acidemia is a marker of prognosis in methanol poisoning, as well as compounding formate-induced cytotoxicity. Prompt correction of acidemia is a key treatment of methanol toxicity and methods to optimize this are poorly defined. OBJECTIVE: We studied the efficiency of acidemia correction by intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) in a mass outbreak of methanol poisoning. METHODS: The study was designed as observational cohort study...
November 7, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27817205/rapid-respiratory-arrest-after-ingestion-of-poison-hemlock-mistaken-for-wild-celery
#9
Hsien-Yi Chen, Howard Horng, Freda Rowley, Craig Smollin
No abstract text is available yet for this article.
November 7, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27813417/corrigendum
#10
(no author information available yet)
No abstract text is available yet for this article.
November 4, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27808572/poisoning-to-%C3%AE-pyrrolidinovalerophenone-%C3%AE-pvp-a-synthetic-cathinone
#11
Neel Patel, Loretta Ford, Rachel Jones, Sally M Bradberry, J Allister Vale
No abstract text is available yet for this article.
November 3, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27806644/coagulation-parameters-in-copperhead-compared-to-other-crotalinae-envenomation-secondary-analysis-of-the-f-ab-2-versus-fab-antivenom-trial
#12
Charles J Gerardo, Joao R Nickenig Vissoci, Michael W J Brown, Sean P Bush
CONTEXT: Coagulation derangements in copperhead envenomation are considered less severe than other crotaline envenomations, resulting in recommendations to limit both coagulation testing and antivenom treatment. A prospective, blinded, multicenter, randomized clinical trial comparing the effectiveness of F(ab')2 versus Fab antivenom in crotaline envenomation patients was completed in 2011. We determined the difference between coagulation parameters in copperhead compared to other crotaline envenomations...
November 3, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27788602/can-a-serum-acetaminophen-concentration-obtained-less-than-4-hours-post-ingestion-determine-which-patients-do-not-require-treatment-with-acetylcysteine
#13
Mark C Yarema, Jason P Green, Marco L A Sivilotti, David W Johnson, Alberto Nettel-Aguirre, Charlemaigne Victorino, Daniel A Spyker, Barry H Rumack
CONTEXT: The interpretation of acetaminophen concentrations obtained prior to 4 hours after an acute, single overdose remains unclear. Patient care decisions in the Emergency Department could be accelerated if such concentrations could reliably exclude the need for treatment. OBJECTIVE: To determine the agreement between a serum acetaminophen concentration obtained less than 4 hours after an acute ingestion and the subsequent 4 + hour concentration, and the predictive accuracy of early concentrations for identifying patients with potentially toxic exposures...
October 28, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27788591/chloroform-ingestion-causing-severe-gastrointestinal-injury-hepatotoxicity-and-dermatitis-confirmed-with-plasma-chloroform-concentrations
#14
Dushan Jayaweera, Shawkat Islam, Naren Gunja, Chris Cowie, James Broska, Latesh Poojara, Michael S Roberts, Geoffrey K Isbister
CONTEXT: Poisoning due to chloroform ingestion is rare. The classic features of acute chloroform toxicity include central nervous system (CNS) and respiratory depression, and delayed hepatotoxicity. CASE DETAILS: A 30-year-old female ingested 20-30 mL of 99% chloroform solution, which caused rapid loss of consciousness, transient hypotension and severe respiratory depression requiring endotracheal intubation and ventilation. She was alert by 12 h and extubated 16 h post-overdose...
October 28, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27775447/a-pediatric-fatality-due-to-accidental-hydromorphone-ingestion
#15
F Lee Cantrell, James Sherrard, Michael Andrade, Bethann Schaber, Iain M McIntyre
BACKGROUND: Death due to prescription opioid exposure has increased dramatically in North America. Currently, there is a lack of literature detailing potentially lethal doses as well as postmortem tissue analysis concentrations from prescription opioid fatalities in children. We report a pediatric hydromorphone fatality with postmortem peripheral blood, central blood, liver, and gastric concentrations. CASE REPORT: A 3-year-old male was found unresponsive on a couch...
October 24, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27758145/defining-predictive-factors-of-severity-and-indications-for-extracorporeal-toxin-removal-in-lithium-poisoning-not-an-easy-objective
#16
Dominique Vodovar, Bruno Mégarbane
No abstract text is available yet for this article.
October 19, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27756153/letter-in-response-to-lithium-poisoning-in-the-intensive-care-unit-predictive-factors-of-severity-and-indications-for-extracorporeal-toxin-removal-to-improve-outcome
#17
Eric Villeneuve, Josh J Wang, Ami M Grunbaum, Sophie Gosselin
No abstract text is available yet for this article.
October 19, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27756148/clinical-effects-of-unintentional-pediatric-buprenorphine-exposures-experience-at-a-single-tertiary-care-center
#18
Michael S Toce, Michele M Burns, Katherine A O'Donnell
CONTEXT: Exploratory buprenorphine ingestions in young children have been associated with clinically significant toxicity. However, detailed data on the clinical presentation and management of these patients are lacking. In an attempt to obtain more comprehensive data, we sought to examine a single center cohort of patients with report of buprenorphine exposure and provide descriptive analysis of rates of respiratory depression, time to respiratory depression, interventions, disposition, and outcomes...
October 19, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27744720/u-47700-reply
#19
Aaron Schneir, Imir G Metushi, Robert L Fitzgerald
No abstract text is available yet for this article.
October 17, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27737559/answer-by-the-authors-to-the-letter-of-dr-wang-and-colleagues-concerning-our-case-report-entitled-idarucizumab-for-dabigatran-overdose
#20
Marijke Peetermans, Peter Verhamme
No abstract text is available yet for this article.
October 14, 2016: Clinical Toxicology
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