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Clinical Toxicology

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https://www.readbyqxmd.com/read/30526136/correction
#1
(no author information available yet)
No abstract text is available yet for this article.
December 11, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30522349/a-bona-fide-need-for-a-non-intravenous-cyanide-medical-countermeasure
#2
Gary A Rockwood
No abstract text is available yet for this article.
December 7, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30522357/berg-adder-bitis-atropos-envenoming-an-analysis-of-14-cases
#3
Andrew John van der Walt, Gert Jacobus Muller
INTRODUCTION: The berg adder (Bitis atropos) is a little-studied, lesser-known viperid snake found in southern Africa and there is limited information available regarding the manifestations of envenoming. MATERIALS AND METHODS: This observational series of 14 cases documents features of berg adder envenoming over a period of 16 years (1987-2003). Clinical features of envenomed patients: All 14 patients developed local cytotoxic effects. Thirteen patients developed systemic effects manifesting and documented in varying degrees...
December 6, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30522351/datura-and-brugmansia-plants-related-antimuscarinic-toxicity-an-analysis-of-poisoning-cases-reported-to-the-taiwan-poison-control-center
#4
Uyen Vy Doan, Ming-Ling Wu, Dong-Haur Phua, Bomar Mendez Rojas, Chen-Chang Yang
INTRODUCTION: Datura and Brugmansia plants, especially Datura species, have been used for their hallucinogenic effects in the United States and Europe; whereas Datura plants have been used as a traditional medicine in many Asian countries. This study was conducted to better understand the pattern and outcome of Datura/Brugmansia plant related poisoning in Taiwan. METHODS: This is a retrospective case series study of all cases with Datura/Brugmansia exposure reported to the Taiwan Poison Control Center between 1986 and 2015...
December 6, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30484713/an-analytically-confirmed-non-fatal-intoxication-by-carfentanil-in-sweden
#5
Lisa Franzén, Olof Beck, Anders Helander
No abstract text is available yet for this article.
November 28, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30484711/prolonged-coma-resulting-from-massive-levothyroxine-overdose-and-the-utility-of-n-terminal-prohormone-brain-natriuretic-peptide-nt-probnp
#6
Ophelia Wong, Anselm Wong, Shaun Greene, Andis Graudins
INTRODUCTION: Levothyroxine overdose rarely results in systemic toxicity. We report a case of intentional levothyroxine overdose with a delayed onset coma and delirium lasting two weeks. CASE SUMMARY: A 72-year-old female ingested 12 mg levothyroxine. Initially, she was drowsy but quickly recovered and was well for the following two days. On day-3 post-overdose her mental state gradually deteriorated. She presented to the hospital with agitation, confusion and dyspnoea...
November 28, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30484705/a-10-year-review-of-single-medication-double-dose-ingestions-in-the-nation-s-largest-poison-control-system
#7
Matthew S Correia, Elizabeth Whitehead, F Lee Cantrell, Daniel R Lasoff, Alicia B Minns
BACKGROUND: Most Americans take at least one medication on a daily basis. Inadvertently ingesting a double-dose of a medication with a narrow therapeutic index may lead to adverse effects. When a patient or medical professional contacts the local poison center after an overdose, a poison specialist fields the incoming information and, depending on the caller, provides specific recommendations. We sought to determine which medication classes were most likely to lead to significant adverse outcomes when an extra dose was ingested...
November 28, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30453788/paracetamol-metabolite-concentrations-following-low-risk-overdose-treated-with-an-abbreviated-12-h-versus-20-h-acetylcysteine-infusion
#8
Anselm Wong, Natalie Homer, James W Dear, Kay Weng Choy, James Doery, Andis Graudins
CONTEXT: To compare degree of liver injury and paracetamol metabolite concentrations after treatment with standard of care (20-h) vs. abbreviated (12-h) acetylcysteine regimens used in paracetamol overdose (NACSTOP trial). METHODS: Timed blood samples from a cohort of subjects enrolled in the cluster-controlled NACSTOP trial evaluating a 12-h acetylcysteine regimen (200 mg/kg over 4 h, 50 mg/kg over 8 h) were assayed for paracetamol metabolites as a pilot study, using liquid chromatography/mass spectrometry...
November 19, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30451029/type-b-botulism-in-a-korean-couple-after-eating-homemade-doenjang
#9
Maricel Dela Cruz, Jane E Miloradovich, Ahmed Mostafa, Rita McKeever, David Vearrier
No abstract text is available yet for this article.
November 17, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30451024/evaluation-of-the-accuracy-of-che-check-mobile-in-measurement-of-acetylcholinesterase-in-pesticide-poisoning
#10
Fathima Shihana, Franz Worek, Gihani A Dassanayake, Surangi H Rathgamage, Jeevan Dhanarisi, Nicholas A Buckley
BACKGROUND: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are used in clinical management to confirm the diagnosis and indicate the severity of organophosphorus and carbamate poisoning. ChE check mobile is a new portable cholinesterase testing system developed in Germany. The study aims to evaluate the accuracy of ChE check mobile compared to the standard reference method and Test-mate ChE system. METHODS: Patients with organophosphorus and carbamate poisoning were recruited from two general hospitals in Sri Lanka between September 2013 and November 2014...
November 17, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30451020/clinical-and-genetic-determinants-of-chronic-visual-pathway-changes-after-methanol-induced-optic-neuropathy-four-year-follow-up-study
#11
Olga Nurieva, Jaroslav A Hubacek, Pavel Urban, Jiri Hlusicka, Pavel Diblik, Pavel Kuthan, Petr Sklenka, Martin Meliska, Jan Bydzovsky, Jarmila Heissigerova, Katerina Kotikova, Tomas Navratil, Martin Komarc, Zdenek Seidl, Manuela Vaneckova, Lucie Vojtova, Sergey Zakharov
CONTEXT: Methanol poisoning induces acute optic neuropathy with possible long-term visual damage. OBJECTIVE: To study the dynamics and key determinants of visual pathway functional changes during 4 years after acute methanol poisoning. METHODS: A total of 42 patients with confirmed methanol poisoning (mean age 45.7 ± 4.4 years) were examined 4.9 ± 0.6, 25.0 ± 0.6, and 49.9 ± 0.5 months after discharge. The following tests were performed: visual evoked potential (VEP), retinal nerve fiber layer (RNFL) measurement, brain magnetic resonance imaging (MRI), complete ocular examination, biochemical tests, and apolipoprotein E (ApoE) genotyping...
November 17, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30451018/prostaglandin-e1-overdose-in-a-term-neonate-with-congenital-heart-disease
#12
Rachel M Gorodetsky, Bethany M Toole, Rachel F Schult, Timothy J Wiegand
No abstract text is available yet for this article.
November 17, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30451016/outbreak-of-haff-disease-caused-by-consumption-of-crayfish-procambarus-clarkii-in-nanjing-china
#13
Baofu Guo, Guoxiang Xie, Xiaocheng Li, Yun Jiang, Di Jin, Yonglin Zhou, Yue Dai, Shiqi Zhen, Guiju Sun
CONTEXT: This paper reports a detailed epidemiological investigation of a large Haff disease outbreak in Nanjing, China, including laboratory analysis of water, river sediment, and fish. METHODS: Structured questionnaires were administered to all case-patients. An unmatched case-control study was conducted to identify the factors affecting the incidence of Haff disease. Thirteen samples of crayfish, together with four samples of water and four samples of sediment were collected and sent for laboratory analysis...
November 17, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30451013/efficacy-and-safety-of-naltrexone-for-amfetamine-and-methamfetamine-use-disorder-a-systematic-review-of-randomized-controlled-trials
#14
Lam Lam, Shweta Anand, Xue Li, M L Tse, Jia X Zhao, Esther W Chan
INTRODUCTION: Amfetamine and methamfetamine abuse remains a prevalent health problem, increasing the burden on healthcare. Naltrexone, a µ-opioid receptor antagonist, has been suggested as a promising treatment for amfetamine and methamfetamine use disorder. OBJECTIVE: To review the current evidence for the efficacy and safety of naltrexone as a pharmacological treatment for amfetamine and methamfetamine use disorder. The primary outcome was defined as abstinence or reduction of use...
November 17, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30451007/challenges-with-take-home-naloxone-in-reducing-heroin-mortality-a-review-of-fatal-heroin-overdose-cases-in-victoria-australia
#15
Nathan C Stam, Dimitri Gerostamoulos, Karen Smith, Jennifer L Pilgrim, Olaf H Drummer
AIM: Take-home naloxone (THN) programs have been implemented in order to reduce the number of heroin-overdose deaths. Because of recent legislative changes in Australia, there is a provision for a greater distribution of naloxone in the community, however, the potential impact of these changes for reduced heroin mortality remains unclear. The aim of this study was to examine the characteristics of the entire cohort of fatal heroin overdose cases and assess whether there was an opportunity for bystander intervention had naloxone been available at the location and time of each of the fatal overdose events to potentially avert the fatal outcome in these cases...
November 17, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30449202/acute-skeletal-fluorosis-in-the-setting-of-1-1-difluoroethane-abuse
#16
Alex Ponce, Jennifer A Oakes, William Eggleston
No abstract text is available yet for this article.
November 17, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30449199/letter-in-response-to-no-influence-of-initial-naloxone-dosage-a-significant-misunderstanding
#17
Felicia Wong, Christopher J Edwards, Daniel H Jarrell, Asad E Patanwala
No abstract text is available yet for this article.
November 17, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30449190/correction
#18
(no author information available yet)
No abstract text is available yet for this article.
November 17, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30449188/accidental-inoculation-of-humans-with-veterinary-vaccines-there-is-no-such-thing-as-zero-risk-a-better-understanding-is-needed
#19
Geraldine Meyer, Florence Jegou, Jean-François Hamel, David Boels
No abstract text is available yet for this article.
November 17, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/30449187/risperidone-medication-errors-in-children-an-analysis-of-french-poison-centres-data
#20
Thierry Vial, Anne-Marie Patat, Nathalie Paret, David Boels, Romain Torrents, Patrick Nisse, Antoine Villa, Behrouz Kassai
OBJECTIVES: To describe clinical consequences of risperidone medication errors in children of less than 13 years and to estimate a clinically relevant toxic dose. METHODS: All cases of risperidone medication errors managed by French Poison Centres from 2001 to 2012 were analyzed. Inclusion criteria were a delay of at least 2 hours between ingestion and request to the FPC in asymptomatic children, an ingested dose above two-fold the maximal daily dose for children above 5 years or any symptomatic patient at the time of first contact...
November 17, 2018: Clinical Toxicology
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