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Asia-Pacific Journal of Clinical Oncology

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https://www.readbyqxmd.com/read/29349927/treatment-related-toxicities-of-immune-checkpoint-inhibitors-in-advanced-cancers-a-meta-analysis
#1
Johnathan Man, Georgia Ritchie, Matthew Links, Sally Lord, Chee Khoon Lee
BACKGROUND: We performed a meta-analysis to quantify toxic death, adverse events (AEs) and treatment discontinuation due to AEs from checkpoint inhibitors (CI). METHODS: We searched for randomized trials with adequate reporting for toxicity outcomes. Pooled risk ratios were estimated for CI versus chemotherapy or different combinations of these agents. RESULTS: Twenty trials of five different cancers with 10 794 patients with performance status 0 or 1 were identified...
January 19, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29345108/high-neutrophil-to-lymphocyte-ratio-predicts-poor-prognosis-in-patients-with-squamous-cell-carcinoma-of-the-head-and-neck-treated-with-definitive-chemoradiotherapy
#2
Sahan Chandrasekara, Sidney Davis, Peter Thomson, Andrew Haydon
AIM: To evaluate the role of neutrophil-to-lymphocyte ratio as a prognostic marker in squamous cell carcinoma of the head and neck treated with definitive chemoradiotherapy. METHODS: A retrospective chart review was performed on patients presenting to our service between 2001 and 2014. Overall survival (OS) and progression-free survival (PFS) were calculated using Kaplan-Meier estimates. The association between neutrophil-to-lymphocyte ratio and survival was analyzed by both univariate and multivariate analysis...
January 17, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29336530/cut-point-for-ki-67-proliferation-index-as-a-prognostic-marker-for-glioblastoma
#3
Eugene Wong, Najmun Nahar, Eric Hau, Winny Varikatt, Val Gebski, Thomas Ng, Jayasingham Jayamohan, Puma Sundaresan
INTRODUCTION: Ki-67 proliferation index (Ki-67 index) is used to quantify cell proliferation during histopathological assessment of various tumors including glioblastoma (GB). AIM: We aimed to assess correlation between Ki-67 index and overall survival in patients with GB and determine a cut-point for Ki-67 index that predicts for poorer survival. METHOD: Records of adult patients diagnosed with GB on histopathological specimens at a tertiary cancer center in Sydney between 1 January 2002 and 30 July 2012 were retrieved...
January 16, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29336525/complications-of-curative-radiation-treatment-for-early-prostate-cancer
#4
Melissa James, Gabrielle McLean, Stephen Williams, Bridget Robinson, Ma Yi
AIM: To report the incidence of urological complications following curative radiation treatment for early prostate cancer, including minimally invasive urological procedures (MUIP), hospital admissions and open surgical procedures. Second malignancies following radiation are also reported and compared with patients undergoing a prostatectomy. METHODS: Included were patients receiving curative intent external beam radiation treatment for early prostate cancer between January 1, 2002, and December 31, 2009...
January 16, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29333702/maml1-and-twist1-co-overexpression-promote-invasion-of-head-and-neck-squamous-cell-carcinoma
#5
Sima Ardalan Khales, Ehsan Ebrahimi, Eisa Jahanzad, Sahar Ardalan Khales, Mohammad Mahdi Forghanifard
AIMS: Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide with considerable morbidity and mortality. Invasion and metastasis of HNSCC is a complex process involving multiple molecules and signaling pathways. Twist Family BHLH Transcription Factor 1 (TWIST1) and Mastermind-like 1 (MAML1) are essential in induction of epithelial-mesenchymal transition through direct regulation of implicated molecules in cellular adhesion, migration and invasion. Our aim in this study was to assess the clinical significance of MAML1 and TWIST1 expression in HNSCC, and elucidate the probable correlation between these genes to exhibit their possible associations with progression and metastasis of the disease...
January 15, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29318751/subgroup-analysis-of-east-asian-patients-in-regard-a-phase-iii-trial-of-ramucirumab-and-best-supportive-care-for-advanced-gastric-cancer
#6
Hyun Cheol Chung, Victor C Kok, Rebecca Cheng, Yanzhi Hsu, Mauro Orlando, Charles Fuchs, Jae Yong Cho
AIM: We describe a subgroup analysis assessing the efficacy and safety of ramucirumab monotherapy in East Asian (EA) patients from the REGARD trial. METHODS: Patients with advanced gastric or gastroesophageal junction adenocarcinoma with progressive disease were randomized 2:1 to receive ramucirumab (8 mg/kg) plus best supportive care (BSC) or placebo plus BSC every 2 weeks. Post hoc subset analyses were performed on the EA and non-EA intention-to-treat populations...
January 10, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29318740/risk-of-febrile-neutropenia-and-early-treatment-cessation-in-men-receiving-standard-and-dose-reduced-3-weekly-docetaxel-for-metastatic-castration-resistant-prostate-cancer
#7
Anis A Hamid, Kaspar Willson, Andrew D Vincent, Babak Tamjid, Margaret Lee, Alice Bergin, Chun Gan, Ainsley Campbell, Josephine Stewart, Carmel Pezaro, Ben Tran, Andrew J Weickhardt
BACKGROUND: Docetaxel is an effective therapy for metastatic castration-resistant prostate cancer (mCRPC); however, many patients experience febrile neutropenia (FN) and cease treatment early due to toxicity. It is not known whether lower dose (LD) q3-weekly docetaxel impacts toxicity or efficacy. METHODS: Multicenter retrospective study included 166 patients with mCRPC who received q3-weekly docetaxel between 2010 and 2015. Demographic, disease, chemotherapy (standard dose, SD>60 mg/m2 vs LD≤60 mg/m2 ) and toxicity data were collected...
January 10, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29316293/estimating-radiotherapy-demands-in-south-east-asia-countries-in-2025-and-2035-using-evidence-based-optimal-radiotherapy-fractions
#8
Noorazrul Yahya, Nurhaziqah Roslan
BACKGROUND AND PURPOSE: As about 50% of cancer patients may require radiotherapy, the demand of radiotherapy as the main treatment to treat cancer is likely to rise due to rising cancer incidence. This study aims to quantify the radiotherapy demand in countries in Southeast Asia (SEA) in 2025 and 2035 using evidence-based optimal radiotherapy fractions. MATERIALS AND METHODS: SEA country-specific cancer incidence by tumor site for 2015, 2025 and 2035 was extracted from the GLOBOCAN database...
January 8, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29316291/immunomodulation-characteristics-by-thermal-ablation-therapy-in-cancer-patients
#9
Wuwei Yang, Wei Wang, Bing Liu, Baorang Zhu, Jing Li, Debao Xu, Yanli Ni, Li Bai, Guangxian Liu
AIM: Thermal ablation therapy has recently emerged as a promising noninvasive treatment modality for localized solid malignancies. Except its direct tumor-cell-killing effect on local tumor tissues, the immunomodulatory effect has also long been noticed which too has substantial effect on clinical outcome, but it is complicated. Though much has been investigated and rich evidences have been achieved, the fundamental state and profile of immunomodulation by thermal ablation in cancer patients, its exact mechanism, especially the systematic mechanism, and its effect on antitumor immunity remain unclear...
January 8, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29316288/carboplatin-plus-pemetrexed-for-the-elderly-incurable-chemo-naive-nonsquamous-non-small-cell-lung-cancer-meta-analysis
#10
Masaru Ito, Nobuyuki Horita, Akimichi Nagashima, Takeshi Kaneko
AIM: In some developed countries, a proportion of nonsquamous non-small cell lung cancer (NSq NSCLC) patients are aged over 70 years when they are diagnosed. However, evidence of lung cancer chemotherapy usually comes from randomized controlled trials that only recruit younger patients with good performance status. In daily practice, less-toxic carboplatin + pemetrexed regimen is often used for elderly patients, although this regimen is not sufficiently supported by rigid evidence for elderly cases...
January 8, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29316254/resveratrol-induced-apoptosis-in-human-gastric-carcinoma-sgc-7901-cells-via-activation-of-mitochondrial-pathway
#11
Yining Yang, Xinen Huang, Senqing Chen, Guojian Ma, Ming Zhu, Feng Yan, Jun Yu
BACKGROUND: Resveratrol is a natural polyphenolic compound and its anticancer effect has been receiving considerable attention. Previous studies showed that resveratrol could inhibited the growth of human gastric carcinoma cells and apoptosis induction was an important mechanism. However, whether mitochondrial pathway was involved in resveratrol-induced apoptosis in human gastric cancer was not very clear. METHODS: The cells were examined by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay, Annexin V/PI staining assay, mitochondrial membrane depolarization, cell morphological assessment, cytochrome c release assay, and Western blotting assay...
January 8, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29282890/efficacy-safety-and-pharmacokinetics-of-subcutaneous-azacitidine-in-chinese-patients-with-higher-risk-myelodysplastic-syndromes-results-from-a-multicenter-single-arm-open-label-phase-2-study
#12
Xin Du, Yue-Yun Lai, Zhijian Xiao, Ting Liu, Yu Hu, Aining Sun, Xiao Li, Zhi-Xiang Shen, Jie Jin, Li Yu, Eric Laille, Qian Dong, Stephen Songer, C L Beach
BACKGROUND: Azacitidine safety and efficacy were established in studies of mainly Caucasian patients. Differences in drug metabolism enzymes between Caucasian and East Asian populations prevent extrapolation of drug effects between these groups. This phase 2 study evaluated azacitidine safety, efficacy and pharmacokinetics in patients with higher-risk myelodysplastic syndromes (HR-MDS) in mainland China. METHODS: Patients aged ≥18 years with HR-MDS were to receive subcutaneous azacitidine 75 mg/m2 /day for 7 days per 28-day cycle, for ≥6 cycles...
December 28, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29280313/efficacy-and-safety-of-oxycodone-naloxone-as-add-on-therapy-to-gabapentin-or-pregabalin-for-the-management-of-chemotherapy-induced-peripheral-neuropathy-in-korea
#13
Bong-Seog Kim, Jong-Youl Jin, Jung Hye Kwon, In Sook Woo, Yoon Ho Ko, Suk-Young Park, Hye-Jeong Park, Jin Hyung Kang
AIMS: To investigate the efficacy and safety of oxycodone/naloxone in patients with chemotherapy-induced peripheral neuropathy (CIPN) inadequately controlled with pregabalin or gabapentin. METHODS: This 4-week, multicenter, interventional, single-arm phase IV study included 72 Korean patients with CIPN inadequately controlled with pregabalin or gabapentin (Numeric Rating Scale 0-10; NRS ≥4 at baseline). In addition to pregabalin or gabapentin at existing doses, patients received 20/10 mg/day oxycodone/naloxone (up-titrated to 80/40 mg/day as needed)...
December 27, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29243413/clinical-response-to-apatinib-monotherapy-in-advanced-non-small-cell-lung-cancer
#14
Jianping Xu, Xiaoyan Liu, Sheng Yang, Xiangru Zhang, Yuankai Shi
AIM: Apatinib, an oral tyrosine kinase inhibitor mainly targeting VEGFR-2, exerts both antiangiogenesis and antiproliferation effects. Apatinib shows clinical benefit in advanced non-small cell lung cancer (NSCLC) at an initial dose of 750 mg qd. We further assessed the efficacy and safety of apatinib at a more frequently used dose of 500 mg qd. The preliminary clinical outcome of apatinib in patients with brain metastases was also reported. METHODS: We retrospectively reviewed the clinical data of 25 patients who received apatinib between August 2015 and May 2016...
December 15, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29226597/prognostic-significance-of-interim-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-volumetric-parameters-in-metastatic-or-recurrent-gastric-cancer
#15
Suk-Young Lee, Hyo Jung Seo, Sungeun Kim, Jae Seon Eo, Sang Cheul Oh
AIM: To evaluate the prognostic role of interim analysis of 18F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) volumetric parameters in patients with recurrent or metastatic advanced gastric cancer (AGC) treated with fluoropyrimidine-based palliative chemotherapy. METHODS: Forty-four patients who underwent baseline and interim PET/CT scanning during palliative chemotherapy were analyzed retrospectively. Initial and change of metabolic parameters (MP) - metabolic tumor volume (MTV), tumor lesion glycolysis (TLG) and maximum and mean standardized uptake values (SUV) were measured with PET/CT...
December 10, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29193796/visibility-of-an-iron-containing-fiducial-marker-in-magnetic-resonance-imaging-for-high-precision-external-beam-prostate-radiotherapy
#16
Osamu Tanaka, Hisao Komeda, Shigeki Hirose, Takuya Taniguchi, Kousei Ono, Masayuki Matsuo
INTRODUCTION: Visualization of fiducial gold markers is critical for registration on computed tomography (CT) and magnetic resonance imaging (MRI) for imaging-guided radiotherapy. Although larger markers provide better visualization on MRI, they tend to generate artifacts on CT. MRI is strongly influenced by the presence of metals, such as iron, in the body. Here we compared efficacies of a 0.5% iron-containing gold marker (GM) and a traditional non-iron-containing marker. METHODS: Twenty-seven patients underwent CT/MRI fusion-based intensity-modulated radiotherapy...
November 29, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29193768/initial-experience-of-sleeve-lobectomy-under-complete-video-assisted-thoracic-surgery
#17
Shaohua Ma, Tianshen Yan, Dandan Liu, Keyi Wang, Jingdi Wang, Jintao Song, Tong Wang, Wei He, Jie Bai, Liang Jin, Hailong Liang
PURPOSE: Review the initial results of a single-center complete video-assisted thoracoscopic surgery (VATS) sleeve lobectomy and discuss the key procedure of this operation, in addition to its safety and feasibility. METHODS: Retrospectively analyze the perioperative data of 11 patients who accepted complete VATS sleeve lobectomy between May 2013 and Jun 2017 in Peking University Third Hospital, try to evaluate the safety of this procedure. All the patients were followed up and their oncological recurrence and metastasis were observed, and feasibility of VATS sleeve lobectomy for lung cancer was evaluated...
November 29, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29171166/outcomes-of-asian-patients-with-localized-prostate-cancer-treated-with-combined-intensity-modulated-radiation-therapy-imrt-and-high-dose-rate-hdr-brachytherapy-a-single-institution-experience
#18
Ivy Wei Shan Ng, Jeremy Chee Seong Tey, Yu Yang Soon, Michelle Shu Fen Tseng, Desiree Chen, Keith Hsiu Chin Lim
AIM: External beam radiotherapy (EBRT) followed by high dose rate (HDR) brachytherapy boost has demonstrated minimal toxicities and improved disease control rate compared with EBRT alone in observational and randomized studies with predominantly Caucasian patients. This study aims to report the outcomes of patients treated with this approach in our predominantly Asian population. METHODS: Medical records for patients with localized prostate cancer who received combined EBRT delivered via intensity modulated radiotherapy (IMRT) technique followed by HDR brachytherapy boost were retrospectively reviewed...
November 23, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29159936/influence-of-socioeconomic-factors-and-distance-to-radiotherapy-on-breast-conserving-surgery-rates-for-early-breast-cancer-in-regional-australia-implications-of-change
#19
Ian M Collins, Caroline Lum, Vincent L Versace
AIMS: Breast conserving surgery rates are affected by many factors including distance to radiotherapy and tumor-related features. Numerous studies have found women who must travel further for radiotherapy are more likely to choose mastectomy and avoid radiotherapy. We examined relationships between socioeconomic group, distance to radiotherapy services and mastectomy rates across a range of rural and metropolitan settings. METHODS: We used a dataset extracted from the Evaluation of Cancer Outcomes Barwon South Western Registry, which captured data on new breast cancer diagnoses in the southwest region of Victoria, Australia...
November 21, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29124894/combined-transcatheter-arterial-chemoembolization-and-radiofrequency-ablation-in-single-session-for-solitary-hepatocellular-carcinoma-larger-than-7%C3%A2-cm
#20
Jie-Yu Yan, Jin-Long Zhang, Mao-Qiang Wang, Kai Yuan, Yan-Hua Bai, Yan Wang, Hai-Nan Xin, Zhi-Jun Wang, Feng-Yong Liu, Feng Duan, Jin-Xin Fu
AIMS: To evaluate technical feasibility and treatment results of combined transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) in single-session for solitary hepatocellular carcinoma (HCC) larger than 7 cm in diameter. METHODS: Institutional review board approved this retrospective study. Written informed consent was obtained from all patients. Between June 2007 and July 2013, 87 patients (75 men, 12 women; mean age, 55.5 years ± 15...
November 10, 2017: Asia-Pacific Journal of Clinical Oncology
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