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Asia-Pacific Journal of Clinical Oncology

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https://www.readbyqxmd.com/read/30421554/prognostic-significance-of-braf-mutation-alone-and-in-combination-with-microsatellite-instability-in-stage-iii-colon-cancer
#1
Hanumant Chouhan, Tarik Sammour, Michelle L Thomas, James W Moore
PURPOSE: The prognostic significance of biomarkers in colorectal cancer is still being defined. This study aimed to determine the prognostic significance of BRAF mutation alone and in combination with microsatellite instability (MSI), in stage III colon cancer. METHODS: Curatively resected stage III colon cancers were studied from a 33-year period. Clinicopathological data were collated (adjuvant chemotherapy, age, gender, obstruction, perforation, tumour location, grade, presence of mucin, nodal stage, extramural vascular, and perineural invasion)...
November 13, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30411509/association-between-pd-l1-expression-and-lymph-node-metastasis-in-cutaneous-squamous-cell-carcinoma
#2
Shiori Kamiya, Junji Kato, Takafumi Kamiya, Toshiharu Yamashita, Yasuyuki Sumikawa, Tokimasa Hida, Kohei Horimoto, Sayuri Sato, Hitomi Takahashi, Masahide Sawada, Terufumi Kubo, Toshihiko Torigoe, Hisashi Uhara
AIM: To clarify the relationship between programmed cell death ligand 1 (PD-L1) expression in cutaneous squamous cell carcinoma (cSCC) and clinicopathological variables. METHODS: We examined PD-L1 expression in tumor cells (TCs) and tumor infiltrating immune cells (ICs) in 46 cases of cSCC by immunohistochemistry. In each case, we employed two methods-intensity and proportion scores-to evaluate PD-L1 expression in TCs. For the evaluation of PD-L1 expression in ICs, only the proportion score was used...
November 8, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30411504/favorable-10-year-outcomes-of-image-guided-intensity-modulated-radiotherapy-combined-with-long-term-androgen-deprivation-for-japanese-patients-with-nonmetastatic-prostate-cancer
#3
Natsuo Tomita, Norihito Soga, Yuji Ogura, Jun Furusawa, Hiroshi Tanaka, Yutaro Koide, Hiroyuki Tachibana, Takeshi Kodira
AIM: To investigate 10-year outcomes of high-dose image-guided intensity-modulated radiation therapy (IG-IMRT) combined with long-term androgen deprivation therapy (ADT) for Japanese patients with nonmetastatic prostate cancer. METHODS: A retrospective analysis was performed on 208 Japanese patients with T1-4N0M0 prostate cancer, who underwent definitive IG-IMRT from 2006 to 2010 at our single institution. The median dose was 78 Gy (74-78) and median ADT time was 32 months (6-151)...
November 8, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30334366/satisfaction-with-pain-management-and-impact-of-pain-on-quality-of-life-in-cancer-patients
#4
Johnson Lin, Ruey-Kuen Hsieh, Jen-Shi Chen, Kuan-Der Lee, Kun-Ming Rau, Yu-Yun Shao, Yung-Chuan Sung, Su-Peng Yeh, Cheng-Shyong Chang, Ta-Chih Liu, Ming-Fang Wu, Ming-Yang Lee, Ming-Sun Yu, Chia-Jui Yen, Pang-Yu Lai, Wen-Li Hwang, Tzeon-Jye Chiou
AIM: To evaluate the prevalence of pain in cancer outpatients in Taiwan and to investigate the impact of pain on quality of life (QoL) and patient satisfaction. Results were compared to those of a similarly designed study conducted in 2008 to identify trends. METHODS: Adult patients with cancer treated as outpatients in hospitals throughout Taiwan were recruited. Pain intensity and the extent to which pain interfered with QoL were self-reported using a modified version of the Brief Pain Inventory...
October 17, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30311393/clinicopathologic-characteristics-and-outcome-of-patients-with-different-egfr-mutations
#5
Shengyu Zhou, Xingsheng Hu, Yan Wang, Junling Li, Liqiang Zhou, Xuezhi Hao, Yutao Liu, Yuankai Shi
AIM: Most epidermal growth factor receptor (EGFR) gene mutations affecting exon 19 (inframe deletions; 19 Del) and 21 (L858R), while the rest (referred as uncommon EGFR mutation) have not been fully described due to their rarity. Here we present a retrospective study that investigated clinical characteristics and outcome of patients with different EGFR mutations. METHODS: We retrospectively analyzed the EGFR mutation pattern and its association with clinical-pathological characteristics from 100 cases of nonsmall-cell lung cancer (NSCLC) harboring EGFR mutations, and compiled the genotype response data for NSCLC patients with common and uncommon EGFR mutations treated with EGFR tyrosine kinase inhibitors (TKIs)...
October 11, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30306711/gender-and-cholesterol-specific-predictive-value-of-body-mass-index-in-renal-cell-carcinoma-a-multicenter-study
#6
Hyun Cheol Jeong, Fahad K Bashraheel, Seok-Soo Byun, Cheol Kwak, Eu Chang Hwang, Seok Ho Kang, Jinsoo Chung, Tae-Hwan Kim, Yong-June Kim, Sung-Hoo Hong
AIM: Recently, there have been some reports on preoperative body mass index (BMI) and total cholesterol (TC) as a prognostic predictor for patients with renal cell carcinoma (RCC) but the topic is controversial and still poorly understood. So we analyzed the effects of BMI and TC on the prognosis of RCC. METHODS: Retrospective data from 1988 to 2015 were collected from eight centers with a total of 7,271 patients surgically treated for nonmetastatic RCC. Receiver operating characteristic curve analysis was analyzed and the highest Youden index was shown at 163...
October 10, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30294856/current-mismatch-repair-deficiency-tumor-testing-practices-and-capabilities-a-survey-of-australian-pathology-providers
#7
Lyon Mascarenhas, Susan Shanley, Gillian Mitchell, Amanda B Spurdle, Finlay Macrae, Nicholas Pachter, Daniel D Buchanan, Robyn L Ward, Stephen Fox, Elaine Duxbury, Rebecca Driessen, Alex Boussioutas
AIM & METHODS: An electronic survey of the Royal College of Pathologists of Australasia accredited pathology services was conducted to assess Lynch syndrome tumor screening practices and to identify barriers and capabilities to screen newly diagnosed colorectal and endometrial tumors in Australia. RESULTS: Australia lacks a national policy for universal mismatch repair-deficient (dMMR) testing of incident colorectal and endometrial tumors cases. Routine Lynch syndrome tumor screening program for colorectal and/or endometrial tumors was applied by 95% (37/39) of laboratories...
October 7, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30270510/national-and-subnational-mortality-of-urological-cancers-in-iran-1990-2015
#8
Farhad Pishgar, Erfan Amini, Kimiya Gohari, Arya Aminorroaya, Ali Sheidaei, Yasna Rostamabadi, Hooman Ebrahimi, Moein Yoosefi, Shohreh Naderimagham, Nazila Rezaei, Mitra Modirian, Alireza Namazi Shabestari, Farzad Kompani, Farshad Farzadfar
PURPOSE: To study trends of urological cancers mortalities in Iran between 1990 and 2015 as a part of a larger project named national and subnational burden of diseases, injuries, and risk factors. METHODS: The primary dataset of this project comprises data of national death registration system. Cause-specific mortality fraction for each age, sex, province, and year group was calculated using a two-stage mixed effects and spatiotemporal models, and then these fractions were applied to all-cause mortality rates, obtained from a parallel study to estimate mortality rates attributable to each cause...
October 1, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30270570/the-outcomes-of-adrenalectomy-for-solitary-adrenal-metastasis-a-17-year-single-center-experience
#9
Koji Hatano, Sayaka Horii, Yasutomo Nakai, Masashi Nakayama, Ken-Ichi Kakimoto, Kazuo Nishimura
AIM: We aimed to analyze surgical outcomes of open or laparoscopic adrenalectomy for solitary adrenal metastasis and assess the factors influencing survival. METHODS: We retrospectively reviewed our institutional clinicopathological database for cases of adrenalectomy for solitary adrenal metastasis from solid tumors between 2000 and 2017. RESULTS: Twenty-five patients underwent open adrenalectomy (n = 11) or laparoscopic adrenalectomy (n = 14)...
September 30, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30270527/the-impact-and-indications-for-oncotype-dx-on-adjuvant-treatment-recommendations-when-third-party-funding-is-unavailable
#10
L Chin-Lenn, R H De Boer, E Segelov, G M Marx, T M Hughes, N J McCarthy, S C White, S S Foo, J J Rutovitz, S Della-Fiorentina, R Jennens, Y C Antill, D Tsoi, M F Cronk, J M Lombard, B E Kiely, J H Chirgwin, A Gorelik, G B Mann
OBJECTIVES: Industry-supported decision impact studies demonstrate that Oncotype Dx (ODX) changes treatment recommendations (TR) in 24-40% of hormone receptor+/HER2- patients. ODX is not reimbursed by third-party payers in Australia, potentially resulting in more selective use. We sought to evaluate the impact of self-funded ODX on TRs. METHODS: Data collected included demographics, tumor characteristics, indication for ODX and pre- and post-recurrence score (RS) TR...
September 30, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30270512/the-prognostic-significance-of-the-expression-of-monocarboxylate-transporter-4-in-patients-with-right-or-left-sided-colorectal-cancer
#11
Yukio Abe, Yoshifumi Nakayama, Takefumi Katsuki, Yuzuru Inoue, Noritaka Minagawa, Takayuki Torigoe, Aiichiro Higure, Tatsuhiko Sako, Naoki Nagata, Keiji Hirata
AIM: Monocarboxylate transporter 4 (MCT4) is a proton pump that exchanges lactate through the plasma membrane. The present study investigated the clinical significance of the expression of MCT4 in patients with right- or left-sided colorectal cancer (CRC). METHODS: Surgical specimens from 237 CRC patients were immunohistochemically stained with polyclonal anti-MCT4 antibodies. The relationships among the MCT4 expression, the clinicopathological factors, and the prognosis were evaluated...
September 30, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30178572/is-concomitant-splenectomy-necessary-in-radical-gastric-cancer-surgery-a-systematic-review-and-meta-analysis
#12
Qiuhong Wang, Tong Dang, Xianmei Meng, Kai Li, Wei Ren, Xiujuan Ma, Ying Huang, Xiaobo Wu, Weijie Han, Dongsheng Zhang, Xiaolong Li, Da Wang, Liansheng Zheng
PURPOSE: This study is a systematic review and meta-analysis compare the short- and long-term outcomes of splenectomy (SP) versus splenic preservation (NSP) in radical gastric cancer surgery. METHODS: A comprehensive search of PubMed, Embase, Cochrane Library and Web of Knowledge was performed. Evaluation of short- and long-term outcomes was collected and analyzed by a fixed or random effects model, according to the heterogeneity using RevMan 5.2 software. RESULTS: A total of 5431 gastric cancer patients who underwent radical surgery (1706 with SP and 3725 with NSP) were reviewed in 11 studies included in this study...
September 4, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30178541/effect-of-c-reactive-protein-albumin-ratio-on-prognosis-in-advanced-non-small-cell-lung-cancer
#13
Xue-Feng Ni, Jun Wu, Mei Ji, Ying-Jie Shao, Bin Xu, Jing-Ting Jiang, Chang-Ping Wu
AIM: Systemic inflammatory response is closely related to tumor progression. We retrospectively investigated relationships between systemic inflammatory scores, C-reactive protein/albumin (CRP/Alb) ratio (CAR) and clinical characteristics in advanced non-small-cell lung cancer (NSCLC) in 436 patients to find better clinical predictors of NSCLC prognosis. METHODS: Blood specimens were collected 1 week before treatment to test for systemic inflammatory scores and albumin...
September 4, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30375737/program-in-detail
#14
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November 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30375736/international-speakers
#15
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November 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30375735/national-speakers
#16
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November 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30375734/floor-plan
#17
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November 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30375733/convenor-s-welcome-2018
#18
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November 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30375732/sponsors-acknowledgements
#19
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November 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/30375731/exhibitor-listing
#20
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November 2018: Asia-Pacific Journal of Clinical Oncology
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