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Asia-Pacific Journal of Clinical Oncology

Richard Quek, Mohamad Farid, Yada Kanjanapan, Cindy Lim, Iain Beehuat Tan, Sittampalam Kesavan, Tony Kiat Hon Lim, Lynette Lin-Ean Oon, Brian Kp Goh, Weng Hoong Chan, Melissa Teo, Alexander Yf Chung, Hock Soo Ong, Wai Keong Wong, Patrick Tan, Desmond Yip
AIM: Benefit of adjuvant imatinib therapy following curative resection in patients with intermediate-risk gastrointestinal stromal tumor (GIST) is unclear. GIST-specific exon mutations, in particular exon 11 deletions, have been shown to be prognostic. We hypothesize that specific KIT mutations may improve risk stratification in patients with intermediate-risk GIST, identifying a subgroup of patients who may benefit from adjuvant therapy. METHODS: In total, 142 GIST patients with complete clinicopathologic and mutational data from two sites were included...
October 17, 2016: Asia-Pacific Journal of Clinical Oncology
Donghong Li, Lihong Chen, Huifang Wang, Hongli Yang, Yuping Dai, Cuige Yu, Yun Dong
AIM: A newly developed cervical cancer screening method - folate receptor-mediated epithelium staining utilizes methylene blue internalized by folate receptor-mediated endocytosis to stain cervical intra-epithelial neoplasia. We test the clinical feasibility of this method in this study. METHODS: A total of 14 344 women who were at least 21 years old and had been sexually active, participated in the study. In gynecological clinics, participants underwent cervical cancer screening with folate receptor-mediated epithelium staining followed by cytology sampling...
October 14, 2016: Asia-Pacific Journal of Clinical Oncology
Anna Kemp-Casey, Elizabeth E Roughead, Christobel Saunders, Frances Boyle, Max Bulsara, David B Preen
AIMS: To determine the frequency, timing and patterns of endocrine therapy switching in Australian practice for postmenopausal women with primary breast cancer. METHODS: We identified postmenopausal women in a population-based cohort commencing endocrine therapy for invasive primary breast cancer between December 2005 and December 2008 (n = 645). Individual-level administrative health records and self-report data were used to determine women's demographic and clinical characteristics, including preexisting and newly-treated comorbidities, and switches in endocrine therapy...
October 14, 2016: Asia-Pacific Journal of Clinical Oncology
Xiaoning Wang, Pengcheng He, Caili Guo, Chunhong Sun, Mei Zhang
INTRODUCTION: To investigate the safety and efficacy of the combination regimen vincristine, cyclophosphamide, melphalan or mitoxantrone and prednisone (VCMP) plus thalidomide as first-line induction therapy for newly diagnosed multiple myeloma (MM). METHODS: Three hundred and ninety-six symptomatic, newly diagnosed MM patients were treated with VCMP plus thalidomide in our hospital for the past 11 years, and clinical data of these patients were retrospectively analyzed...
October 14, 2016: Asia-Pacific Journal of Clinical Oncology
Mimi C Yue, Joel T Collins, Elango Subramoniapillai, Glen A Kennedy
AIM: To describe a nosocomial outbreak of H1N1 influenza A in an inpatient hematology and allogeneic stem cell transplant unit and outcomes of universal oseltamivir prophylaxis. METHODS: Medical records of all patients admitted to the unit were reviewed to define the nosocomial outbreak, commencing 1 week prior to the index case until 4 weeks following institution of oseltamivir prophylaxis. Timelines for clinical symptoms, viral spread, management, patient outcomes and follow up testing were constructed...
October 12, 2016: Asia-Pacific Journal of Clinical Oncology
Kim-Lin Chiew, Shanley Chong, Kirsten J Duggan, Nasreen Kaadan, Shalini K Vinod
AIM: To investigate adherence to clinical practice guidelines (CPGs) in cervical cancer and the correlation with clinical outcomes. METHODS: A retrospective analysis was conducted using patient information from a population-based cancer registry (2005-2011, n = 208). Compliance to 10 widely accepted CPGs was assessed. Univariate and multivariate analyses were performed to assess sociodemographic factors associated with CPG adherence. Multivariate Cox regression was performed to assess the relationship between CPG adherence and 5-year survival...
October 11, 2016: Asia-Pacific Journal of Clinical Oncology
Kelsey Wong, Margaret Lee, Ian D Davis, Phillip Parente, Joseph Mckendrick, Carmel Pezaro
Posterior reversible encephalopathy syndrome (PRES) has been described in the context of uncontrolled hypertension, eclampsia, renal disease and autoimmune conditions, or in patients treated with chemotherapy or immunosuppressive agents. In contrast, we report the occurrence of PRES in a patient with untreated metastatic transitional cell carcinoma. The case emphasizes important diagnostic challenges associated with atypical presentations without "typical" risk factors and the limitations of common diagnostic imaging modalities...
October 11, 2016: Asia-Pacific Journal of Clinical Oncology
Bin Liu, Yuliang Li, Yongzheng Wang, Wujie Wang, Lili Wang, Yancu Hertzanu, Junjie Wang, Fujun Zhang
AIM: Certain metastasis-containing middle mediastinal lymph nodes cannot be approached by standard CT-guided brachytherapy. We here describe a novel trans-superior vena cava approach for such nodes. The aim of this prospective study was to assess the safety and clinical value of (125) iodine (I) brachytherapy via a trans-superior vena cava approach in patients with metastases in middle mediastinal lymph nodes. METHODS: From February 2008 to October 2011, 32 patients with 43 pathologically confirmed metastasis-containing mediastinal middle lymph nodes underwent CT-guided percutaneous (125) I brachytherapy via a trans-superior vena cava approach...
September 29, 2016: Asia-Pacific Journal of Clinical Oncology
Wenxue Chen, Shaohua Lu, Guifang Wang, Fener Chen, Chunxue Bai
AIM: High-resolution magic-angle spinning proton nuclear magnetic resonance (HRMAS (1) H NMR) spectroscopy technique was employed to analyze the metabonomic characterizations of lung cancer tissues in hope to identify potential diagnostic biomarkers for malignancy detection and staging research of lung tissues. METHODS: HRMAS (1) H NMR spectroscopy technique can rapidly provide important information for accurate diagnosis and staging of cancer tissues owing to its noninvasive nature and limited requirement for the samples, and thus has been acknowledged as an excellent tool to investigate tissue metabolism and provide a more realistic insight into the metabonomics of tissues when combined with multivariate data analysis (MVDA) such as component analysis and orthogonal partial least squares-discriminant analysis in particular...
September 27, 2016: Asia-Pacific Journal of Clinical Oncology
Ja Yoon Ku, Chan Ho Lee, Jeong Zoo Lee, Hong Koo Ha
AIM: To compare the functional outcomes after laparoscopic radical prostatectomy (LRP) and robot-assisted laparoscopic radical prostatectomy (RARP). METHODS: Between September 2008 and January 2016, 712 patients underwent radical prostatectomy (RP; 614 LRP and 98 RARP). Recovery of incontinence was evaluated through a 24-h pad test. Urinary and erectile function was evaluated using the International Prostate Symptom Score (IPSS) and the International Index of Erectile Function-5...
September 26, 2016: Asia-Pacific Journal of Clinical Oncology
Vikram Joshi, Barbara-Ann Adelstein, Andrea Schaffer, Preeyaporn Srasuebkul, Timothy Dobbins, Sallie-Anne Pearson
BACKGROUND: Routine data collections are used increasingly to examine outcomes of real-world cancer drug use. These datasets lack clinical details about important endpoints such as disease progression. AIM: To validate a proxy for disease progression in metastatic cancer patients using prescribing and dispensing claims. METHODS: We used data from a cohort study of patients undergoing chemotherapy who provided informed consent to the collection of cancer-treatment data from medical records and linkage to pharmaceutical claims...
September 26, 2016: Asia-Pacific Journal of Clinical Oncology
Harminder Takhar, Anna Rachelle Mislang, Nimit Singhal, Michael P Brown
AIM: Autologous hematopoietic stem cell transplantation (auto-HSCT) remains an experimental therapy for metastatic breast cancer (MBC) and there is no established protocol for cluster of differentiation 34(+) (CD34(+) ) hematopoietic progenitor cell (HPC) mobilization with historic studies using growth factors with or without chemotherapy. This study describes the feasibility and kinetics of CD34(+) HPC mobilization following a single administration of docetaxel and the pegylated form of recombinant human granulocyte colony-stimulating factor analogue filgrastim (pegfilgrastim)...
September 21, 2016: Asia-Pacific Journal of Clinical Oncology
Alvin Lee, Joel Lim, Xiao Gao, Lizhen Liu, Sing Joo Chia
AIM: To develop and internally validate two nomograms for predicting the probability of overall and clinically-significant prostate cancer on initial biopsy in a Singaporean population. METHODS: Data were collected from men undergoing initial prostate biopsy at a single center. The indications for biopsy were serum prostate-specific antigen (PSA) ≥4.0 ng/mL or suspicious digital rectal examination (DRE) findings. Men with PSA >30 ng/mL were excluded. Age, PSA, prostate volume (PV) and DRE were predictors included in our logistic regression model and used to construct two nomograms for overall prostate cancer and clinically-significant (Gleason sum ≥7) cancer detection...
September 19, 2016: Asia-Pacific Journal of Clinical Oncology
Lei Zhang, Xuegang Liu, Xiaojun Li, Zhen Tang, Chao Shi, Gengming Wang
AIM: The aim of this study was to investigate the clinical features as well as the diagnosis and treatment methods for mediastinal solitary fibrous tumor (MSFT). METHODS: The clinical data of 13 patients treated for pathologically confirmed MSFT were retrospectively analyzed. The clinical symptoms were mainly cough, chest tightness, chest pain and chest discomfort. It was difficult to distinguish MSFT from other types of tumors simply via imaging results, hence, the confirmative diagnosis required pathological and immunohistochemistry analysis...
September 19, 2016: Asia-Pacific Journal of Clinical Oncology
Amir Valikhani, Behzad Poopak, Shirin Ferdowsi, Ghasem Azizi Tabesh, Seyed H Ghaffari, Ehsan Saraf Kazeruoni, Negar Rezaei, Alireza Farshchi, Naser Amirizadeh
AIM: In recent years, a few cases of chronic myeloid leukemia (CML) have been reported with both BCR-ABL and JAK2V617F mutations. Moreover, mutations in the additional sex comb-like 1 (ASXL1) gene were recently shown in various myeloid malignancies.There were no previous studies investigating the incidence of the ASXL1 and JAK2V617F mutations in Iranian patients with CML. Consequently, this study focuses on the analysis of these mutations in patients with CML. METHODS: In total, 66 patients with a clinical diagnosis of CML were examined at the time of diagnosis...
September 19, 2016: Asia-Pacific Journal of Clinical Oncology
M Sakaguchi, T Maebayashi, T Aizawa, N Ishibashi, T Saito
AIM: Important factors typically associated with prognosis in brain metastases include Karnofsky performance status (KPS), extracranial or cerebellar localization and combination chemotherapy. However, few studies investigated the prognostic role of leptomeningeal metastases (LM) following whole brain radiotherapy (WBRT). On the basis of our experience suggesting better survival of asymptomatic patients with LM than those with brain metastases, we herein evaluated LM as a prognostic factor after WBRT...
September 13, 2016: Asia-Pacific Journal of Clinical Oncology
Paula Cronin, Brent Kirkbride, Albert Bang, Bonny Parkinson, David Smith, Philip Haywood
AIM: Prostate cancer (PCa) is the most commonly diagnosed cancer in Australian males. There are limited data on the long-term health system costs associated with PCa. The aim of this study is to estimate long-term health care costs of PCa. METHODS: We estimated the health system costs for a cohort of 1873 males diagnosed with PCa between 2000 and 2002, using linked medical, pharmaceutical and hospital data. Treatment was defined by an initial phase, measuring health care costs up to 6 months following diagnosis and a continuing phase (including metastatic treatment), measuring treatments to 9...
September 13, 2016: Asia-Pacific Journal of Clinical Oncology
Rebecca L Mercieca-Bebber, Melanie A Price, Melanie L Bell, Madeleine T King, Penelope M Webb, Phyllis N Butow
AIMS: Participant drop out is a major barrier to high-quality patient-reported outcome (PRO) data analysis in cancer research as patients with worsening health are more likely to dropout. To test the hypothesis that ovarian cancer patients with worse PROs would drop out earlier, we examined how patients differed by time of dropout on health-related quality of life (HRQOL), anxiety, depression, optimism and insomnia. METHODS: This analysis included 619 participants, stratified by time of dropout, from the Australian Ovarian Cancer Study - Quality of Life substudy, in which participants completed PRO questionnaires at three-monthly intervals for 21 months...
August 30, 2016: Asia-Pacific Journal of Clinical Oncology
Puma Sundaresan, Madeleine King, Martin Stockler, Daniel Costa, Christopher Milross
AIMS: Radiation therapy (RT) is an essential and cost-effective cancer treatment, but it is underutilized in Australia. We aimed to quantify consumers' perceptions of factors that influence RT decisions. METHODS: A cross-sectional, survey-based study was conducted in March-August 2012. Potential participants were invited to complete an electronic survey disseminated through multiple patient support and advocacy groups throughout New South Wales (NSW), Australia...
August 30, 2016: Asia-Pacific Journal of Clinical Oncology
Audrey A Thomas, Alison Pearce, Linda Sharp, Robert Alexander Gardiner, Suzanne Chambers, Joanne Aitken, Michal Molcho, Peter Baade
AIM: We examined how sociodemographic, clinical and area-level factors are related to short-term prostate cancer mortality versus mortality from other causes, a crucial distinction for this disease that disproportionately affects men older than 60 years. METHODS: We applied competing risk survival models to administrative data from the Queensland Cancer Registry (Australia) for men diagnosed with prostate cancer between January 2005 and July 2007, including stratification by Gleason score...
August 25, 2016: Asia-Pacific Journal of Clinical Oncology
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