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Asia-Pacific Journal of Clinical Oncology

Qiuhong Wang, Tong Dang, Xianmei Meng, Kai Li, Wei Ren, Xiujuan Ma, Ying Huang, Xiaobo Wu, Weijie Han, Dongsheng Zhang, Xiaolong Li, Da Wang, Liansheng Zheng
PURPOSE: This study is a systematic review and meta-analysis compare the short- and long-term outcomes of splenectomy (SP) versus splenic preservation (NSP) in radical gastric cancer surgery. METHODS: A comprehensive search of PubMed, Embase, Cochrane Library and Web of Knowledge was performed. Evaluation of short- and long-term outcomes was collected and analyzed by a fixed or random effects model, according to the heterogeneity using RevMan 5.2 software. RESULTS: A total of 5431 gastric cancer patients who underwent radical surgery (1706 with SP and 3725 with NSP) were reviewed in 11 studies included in this study...
September 4, 2018: Asia-Pacific Journal of Clinical Oncology
Xue-Feng Ni, Jun Wu, Mei Ji, Ying-Jie Shao, Bin Xu, Jing-Ting Jiang, Chang-Ping Wu
AIM: Systemic inflammatory response is closely related to tumor progression. We retrospectively investigated relationships between systemic inflammatory scores, C-reactive protein/albumin (CRP/Alb) ratio (CAR) and clinical characteristics in advanced non-small-cell lung cancer (NSCLC) in 436 patients to find better clinical predictors of NSCLC prognosis. METHODS: Blood specimens were collected 1 week before treatment to test for systemic inflammatory scores and albumin...
September 4, 2018: Asia-Pacific Journal of Clinical Oncology
Yoshimasa Saito, Tadashi Kumamoto, Miki Shiraiwa, Tomoko Sonoda, Ayumu Arakawa, Hironobu Hashimoto, Ikumi Tamai, Chitose Ogawa, Hiroyuki Terakado
AIM: Although hemorrhagic cystitis (HC) is a significant complication in young patients who undergo chemotherapy with cyclophosphamide (CPA), risk factors and supportive care to prevent HC are unclear. This study attempted to identify optimal supportive care to prevent CPA-induced HC. METHODS: Patients (< 30-year-old) with malignant solid tumors who had been treated with CPA-containing chemotherapy in inpatient treatment were eligible. Vigorous hydration to increase urine output and intravenous 2-mercaptethane sulfonate (mesna) were used for prophylaxis of CPA-induced HC...
July 10, 2018: Asia-Pacific Journal of Clinical Oncology
Takeshi Kotake, Hironaga Satake, Yoshihiro Okita, Yukimasa Hatachi, Mamiko Hamada, Masatomo Omiya, Hisateru Yasui, Toru Hashida, Satoshi Kaihara, Tetsuro Inokuma, Akihito Tsuji
BACKGROUND: Reports of hepatitis B virus (HBV) reactivation in solid tumors are very limited, and their frequencies and risk factors were previously unknown. AIM: To evaluate the prevalence and risk factors of HBV reactivation in patients with solid tumors with resolved HBV infection. METHODS: All 1088 patients with solid tumors were assessed for eligibility; 251 patients had resolved HBV infection (negative for HBs antigen and positive for anti-HBc antibody and/or positive for anti-HBs antibody), and HBV-DNA was assessed for 243 of these patients in whom we analyzed the prevalence of HBV reactivation...
July 8, 2018: Asia-Pacific Journal of Clinical Oncology
Cheng-Hao Chuang, Jui-Feng Hsu, Yu-Ting Shen, Chih-Jen Yang
An abscopal effect refers to distant tumor regression after localized irradiation. The mechanism is thought to be via local radiotherapy triggering the immune system which then attacks distant tumor sites. Only several cases of solid tumors with an abscopal effect have been reported in the past few decades, and whether an abscopal effect can cross the blood-brain barrier is still unknown. Herein, we present a female patient who was admitted due to unsteady gait and dyspnea. Chest X-ray (CXR) and chest CT showed a huge lung mass with left lung collapse and multiple liver masses...
July 8, 2018: Asia-Pacific Journal of Clinical Oncology
Yoshimi Ishii, Shin Fujisawa, Taiki Ando, Taisei Suzuki, Yasufumi Ishiyama, Kumiko Kishimoto, Yukako Hattori, Yuki Nakajima, Takuya Miyazaki, Hirotaka Takasaki, Kenji Matsumoto, Hideyuki Koharazawa, Jun Taguchi, Katsumichi Fujimaki, Rika Sakai, Hideaki Nakajima
AIM: Primary malignant lymphomas arising from the female genital tract are very rare, with an incidence rate of 0.5%. Because of its rarity, its clinical characteristics, prognosis and optimal treatment are still unclear. Here, we retrospectively evaluated female patients with uterine lymphoma. METHODS: Between January 2000 and October 2016, 4362 patients were newly diagnosed with malignant lymphoma by the participating institutions of YACHT. Among these 4362 patients, we retrospectively evaluated 14 adult patients with primary uterine lymphoma...
July 8, 2018: Asia-Pacific Journal of Clinical Oncology
Siavash Foroughi, Hui-Li Wong, Lucy Gately, Margaret Lee, Koen Simons, Jeanne Tie, Antony Wilks Burgess, Peter Gibbs
Substantial progress has recently been made in optimizing the management of cancer patients, resulting in major gains in survival and quality of life. Much of this progress has resulted from the serial testing of promising treatment strategies, typically using prospective randomized controlled trials to compare outcomes achieved with the new approach versus the current standard(s) of care. However, there is an ever-expanding list of important questions that are difficult to investigate, particularly with respect to determining the optimal sequencing and combination of proven active agents...
June 26, 2018: Asia-Pacific Journal of Clinical Oncology
Jiaxiong Tan, Shaohua Chen, Jingying Huang, Youchun Chen, Lijian Yang, Chunli Wang, Jun Zhong, Yuhong Lu, Liang Wang, Kanger Zhu, Yangqiu Li
AIM: The immunosuppressive microenvironment plays a crucial role in T-cell immunodeficiency in multiple myeloma (MM). Overexpression of T-cell immunosuppressive receptors, including programmed death-1 (PD-1) and T-cell immunoglobulin and mucin-domain-containing-3 (Tim-3), may be related to tumor immunosuppression and poor prognosis, and the malignant bone marrow (BM) microenvironment may contribute to such immunosuppression. The purpose of this study was to analyze the distribution of PD-1+ and/or Tim-3+ T cells in different T-cell subset in patients with MM...
June 25, 2018: Asia-Pacific Journal of Clinical Oncology
Rahul Ladwa, Victoria Atkinson
AIM: Improved systemic treatment has improved the prognosis of metastatic melanoma (MM). However, brain metastases (BMs) are a frequent complication. We aimed to explore the outcome of these patients with modern therapeutic options. METHOD: We retrospectively analyzed 142 patients diagnosed with BM from MM at two institutions in Brisbane, Queensland, Australia during 2009-2016. Basic clinico-pathological parameters, treatments used and mortality data were collected...
June 22, 2018: Asia-Pacific Journal of Clinical Oncology
Akira Hirano, Hiroaki Inoue, Kaoru Ogura, Akinori Hattori, Hiroko Yukawa, Shiho Sakaguchi, Aya Matsuoka, Natsuko Tanaka, Asaka Kodera, Mari Kamimura, Yoshihiko Naritaka, Tadao Shimizu
PURPOSE: Unlike anastrozole, the effect of long-term exemestane (EXE) therapy on bone mineral density (BMD) is still unknown. We assessed changes in BMD from baseline to 5 years of EXE treatment. METHODS: Postmenopausal women with endocrine-responsive breast cancer receiving EXE as adjuvant therapy were enrolled in this study. EXE was administered for 5 years. The BMD of the lumbar spine (LS) and femoral neck (FN) was assessed by dual-energy X-ray absorptiometry at baseline and after 6 months and 1, 2, 3, 4, 5 and 6 years...
June 22, 2018: Asia-Pacific Journal of Clinical Oncology
Sally L Brooks, Gail Rowan, Michael Michael
AIM: Complementary medicine (CAM) use in the cancer population is higher than the general population: some studies estimate up to 70%. Our Medicines Information Centre, in a tertiary cancer institution, receives many enquiries regarding use and safety of CAM with conventional cancer therapies (chemotherapy, radiotherapy and surgery). This project aims to review the CAM most commonly enquired about with an emphasis on potential interactions with conventional cancer therapies. METHODS: An audit and review of CAM enquiries from patients or medical professionals at our center, over a 2-year period (July 2011-June 2013), was conducted...
June 22, 2018: Asia-Pacific Journal of Clinical Oncology
Yuwei Yang, MengMeng Zhou, Mingjun Hu, Yanjie Cui, Qi Zhong, Ling Liang, Fen Huang
BACKGROUND: Previous articles explored the role of UGT1A1 polymorphism on predicting irinotecan-induced toxicity, but the conclusions were still inconsistent and not comprehensive. We performed this meta-analysis to investigate the association between UGT1A1 polymorphism and irinotecan-induced toxicity. METHODS: PubMed and Web of Science were searched for articles before July 2017. Inclusion and exclusion criteria were set to select eligible articles, and corresponding data were extracted from those articles...
June 22, 2018: Asia-Pacific Journal of Clinical Oncology
Rosemary Young, Paul Mainwaring, Philip Clingan, Francis Xavier Parnis, Gholamreza Asghari, Philip Beale, Abdalla Aly, Marc Botteman, Alfredo Romano, Stefano Ferrara, Sandra Margunato-Debay, Marion Harris
AIM: The phase III MPACT trial (N = 861) demonstrated superior overall survival (OS) with first-line nab-paclitaxel plus gemcitabine versus gemcitabine alone (median, 8.7 months vs 6.6 months; hazard ratio [HR], 0.72; 95% confidence interval [CI], 0.62-0.83; P < 0.001) in patients with metastatic pancreatic cancer. The efficacy benefit of the combination over gemcitabine alone was observed across patient subgroups, including those based on region. This subset analysis was designed to examine the safety and efficacy of nab-paclitaxel plus gemcitabine in patients treated in Australia to understand whether differences in patient population or regional variations in patient care had any impact on clinical outcomes...
June 22, 2018: Asia-Pacific Journal of Clinical Oncology
James C H Chow, Kwok Hung Au, Oscar W K Mang, Ka Man Cheung, Roger K C Ngan
AIM: Second primary tumor (SPT) is a serious late complication after definitive radiotherapy for nasopharyngeal carcinoma (NPC). We evaluated the incidence, pattern, risk factors and survival impact of SPT in NPC patients following definitive intensity-modulated radiotherapy (IMRT). METHODS: A retrospective review of 780 consecutive IMRT-treated NPC patients between February 2003 and September 2011 was conducted. Cumulative SPT incidence and overall survival after SPT diagnosis were estimated...
June 22, 2018: Asia-Pacific Journal of Clinical Oncology
Ivy Weishan Ng, Yu Yang Soon, Desiree Chen, Jeremy Chee Seong Tey
PURPOSE: To determine the benefit of adding radiotherapy (RT) to chemotherapy for patients with locally advanced unresectable pancreatic cancer (LAUPC). METHODS: We searched MEDLINE for comparative studies comparing chemoradiotherapy with chemotherapy for patients with LAUPC. We performed the meta-analysis with random effects model. The primary outcome was overall survival (OS); secondary outcomes include progression-free survival (PFS) and adverse events (AE). RESULTS: We found five randomized (RCT) and three observational studies (OBS) including 830 patients...
June 22, 2018: Asia-Pacific Journal of Clinical Oncology
Luigi A Sposato, Yick Lam, Chris Karapetis, Sina Vatandoust, Amitesh Roy, Paul Hakendorf, Andrew Dwyer, Dayan de Fontgalland, Paul Hollington, David Wattchow
AIM: Observation with close follow-up ("watch and wait") is a recognized treatment option in patients who achieve a complete clinical response to long course chemoradiotherapy. This review of a prospective database aims to evaluate the clinical outcomes among patients with a complete clinical response managed with observation. METHODS: A prospective study of 32 patients who achieved a complete clinical response was undertaken. The primary outcomes measured were overall and recurrence-free survival, and rate of organ preservation in patients who deferred immediate surgery...
June 22, 2018: Asia-Pacific Journal of Clinical Oncology
Yan Mi, Yinlong Zhao, Fang Shi, Mengmeng Zhang, Chunpeng Wang, Xin Liu
AIM: Urine cytokeratin 20 (CK20) has been reported as a novel diagnostic biomarker for bladder cancer (BC). This meta-analysis aims to evaluate the diagnostic value of urine CK20 for BC. METHODS: A systematic search for literatures was performed till March 31, 2018. Sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and the area under the summary receiver operator characteristic curve (AUC) were analyzed...
June 22, 2018: Asia-Pacific Journal of Clinical Oncology
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July 2018: Asia-Pacific Journal of Clinical Oncology
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July 2018: Asia-Pacific Journal of Clinical Oncology
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July 2018: Asia-Pacific Journal of Clinical Oncology
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