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Neuropsychiatric Disease and Treatment

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https://www.readbyqxmd.com/read/28053535/atypical-major-depressive-episode-as-initial-presentation-of-intracranial-germinoma-in-a-male-adolescent
#1
Yi-Ting Chen, Kuan-Pin Su, Jane Pei-Chen Chang
A 17-year-old adolescent boy presented with atypical major depressive episode (MDE) without specific focal neurological signs for 6 months. He had a diagnosis of intra-cranial germinoma, and the atypical MDE symptoms subsided after the operation. However, he had a relapse of atypical MDE 7 months after the first surgery. His mood and binge eating symptoms subsided, but intractable body weight gain only partially improved after treatment. When encountering manifestations of depression with atypical features, especially with binge eating symptoms in male children and adolescents, with early onset age, no family history, and prolonged depressive episodes, clinicians should consider not only mood disorders including bipolar spectrum disorders but also organic brain lesions such as intracranial germinoma...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28053534/detailed-course-of-depressive-symptoms-and-risk-for-developing-depression-in-late-adolescents-with-subthreshold-depression-a-cohort-study
#2
Ran Jinnin, Yasumasa Okamoto, Koki Takagaki, Yoshiko Nishiyama, Takanao Yamamura, Yuri Okamoto, Yoshie Miyake, Yoshitake Takebayashi, Keisuke Tanaka, Yoshinori Sugiura, Haruki Shimoda, Norito Kawakami, Toshi A Furukawa, Shigeto Yamawaki
PURPOSE: Despite its clinical importance, adolescent subthreshold depression remains a largely neglected topic. The aims of this study were to accurately identify the natural course of depressive symptoms and the risk for developing major depressive episode (MDE) in late adolescents with subthreshold depression over 1 year. PATIENTS AND METHODS: One hundred and seventy-two participants <20 years of age (mean age: 18.32 years, standard deviation: 0.50), who did not meet the full criteria for an MDE, were selected from 2,494 screened freshmen based on the Beck Depression Inventory, 2nd edition (BDI-II)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28031714/temperament-personality-and-treatment-outcome-in-major-depression-a-6-month-preliminary-prospective-study
#3
Yuka Kudo, Atsuo Nakagawa, Taisei Wake, Natsumi Ishikawa, Chika Kurata, Mizuki Nakahara, Teruo Nojima, Masaru Mimura
BACKGROUND: Despite available treatments, major depression is a highly heterogeneous disorder, which leads to problems in classification and treatment specificity. Previous studies have reported that personality traits predict and influence the course and treatment response of depression. The Temperament and Personality Questionnaire (T&P) assesses eight major constructs of personality traits observed in those who develop depression. The aim of this study was to investigate the influence of T&P's eight constructs on the treatment outcome of depressed patients...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28031713/pioglitazone-could-induce-remission-in-major-depression-a-meta-analysis
#4
Romain Colle, Delphine de Larminat, Samuel Rotenberg, Franz Hozer, Patrick Hardy, Céline Verstuyft, Bruno Fève, Emmanuelle Corruble
BACKGROUND: Pioglitazone, a selective agonist of the nuclear transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-γ), prescribed for the treatment of type 2 diabetes, could have antidepressant properties. However, its potential to induce remission of major depressive episodes, the optimal clinical target for an antidepressant drug, is a matter of concern. Indeed, only one out of four double-blind randomized controlled trials show higher remission rates with pioglitazone than with control treatments...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28031712/minocycline-and-celecoxib-as-adjunctive-treatments-for-bipolar-depression-a-study-protocol-for-a-multicenter-factorial-design-randomized-controlled-trial
#5
Muhammad I Husain, Imran B Chaudhry, Munir M Hamirani, Fareed A Minhas, Ajmal Kazmi, John Hodsoll, Peter M Haddad, John Fw Deakin, Nusrat Husain, Allan H Young
BACKGROUND: Evidence suggests that the use of anti-inflammatory agents may improve depressive symptoms in patients with bipolar affective disorder. However, there are few well-designed clinical trials demonstrating the efficacy of these newer treatment strategies. PATIENTS AND METHODS: This is a multicenter, 3-month, randomized, placebo-controlled, double-blind, factorial design trial of minocycline and/or celecoxib added to TAU for the treatment of depressive symptoms in patients experiencing a DSM-5 bipolar I or II disorder and a current major depressive episode...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28053533/drug-therapy-of-epileptic-seizures-among-adult-epileptic-outpatients-of-university-of-gondar-referral-and-teaching-hospital-gondar-north-west-ethiopia
#6
Eshetie Melese Birru, Miftah Shafi, Mestayet Geta
OBJECTIVE: The aim of this study was to assess the practice of pharmacotherapy of epilepsy and its treatment outcomes in adult epileptic outpatients at the University of Gondar Referral and Teaching Hospital, Gondar, North West Ethiopia. METHODS: An institution based, retrospective cross-sectional study was conducted from the medical charts of 336 adult epileptic patients at the outpatient epileptic clinic of Neurology Department of University of Gondar Teaching Hospital from May 2014 to April 2015...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28008260/association-between-the-high-dose-use-of-benzodiazepines-and-rehospitalization-in-patients-with-schizophrenia-a-2-year-naturalistic-study
#7
Yukika Takita, Yoshikazu Takaesu, Kotaro Ono, Kunihiro Futenma, Akiyoshi Shimura, Akiko Murakoshi, Yoko Komada, Yuichi Inoue, Takeshi Inoue
BACKGROUND: High-dose use of benzodiazepines (BZPs) reportedly causes adverse effects on cognitive function and quality of life in patients with schizophrenia. However, effects of BZPs on the clinical course of schizophrenia have not been clarified. This study was set out to investigate the association between BZPs and rehospitalization of patients with schizophrenia. METHODS: In this retrospective study, patients with schizophrenia who were discharged from Tokyo Medical University Hospital between January 2009 and February 2012 were eligible as subjects...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28008259/efficacy-and-tolerability-of-topiramate-augmentation-therapy-for-schizophrenia-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#8
Yuji Okuyama, Kazuto Oya, Shinji Matsunaga, Taro Kishi, Nakao Iwata
This study aimed to perform a comprehensive meta-analysis of topiramate-augmentation therapy in patients with schizophrenia receiving antipsychotic agents. Data published up to June 20, 2016 were obtained from the PubMed, PsycINFO, and Cochrane Library databases. Twelve randomized controlled trials comparing topiramate to placebo or antipsychotic only were included (n=676 patients). The primary outcome was change in overall symptoms. Relative risk (RR) and standardized mean difference (SMD), along with 95% confidence intervals, were calculated using random effects model for each outcome...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28008258/incidence-risk-factors-and-phenomenological-characteristics-of-postoperative-delirium-in-patients-receiving-intravenous-patient-controlled-analgesia-a-prospective-cohort-study
#9
Yao Tsung Lin, Kuo Mao Lan, Li-Kai Wang, Chin-Chen Chu, Su-Zhen Wu, Chia-Yu Chang, Jen-Yin Chen
BACKGROUND: Intravenous patient-controlled analgesia (IVPCA) is a common method of relieving pain which is a risk factor of postoperative delirium (POD). However, research concerning POD in IVPCA patients is limited. OBJECTIVE: We aimed to determine the incidence, risk factors, and phenomenological characteristics of POD in patients receiving IVPCA. METHODS: A prospective, cohort study was conducted in post-general anesthesia IVPCA patients aged ≥60 years...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28008257/non-24-hour-sleep-wake-syndrome-improved-by-low-dose-valproic-acid-a-case-report
#10
Masatake Kurita, Takahiro Moriya, Satoshi Nishino, Eishin Hirata, Noriyasu Hirasawa, Yoshiro Okubo, Tadahiro Sato
A woman was diagnosed with non-24-hour sleep-wake syndrome and depressive symptoms. Her depressive symptoms did not respond to standard doses of several antidepressants or mood stabilizers. Furthermore, her sleep-wake cycle remained non-entrained despite treatment with a melatonin-related drug, vitamin B12, and phototherapy. Ultimately, her sleep-wake rhythm was restored to a 24-hour pattern with a low dose of valproic acid, and her depressive symptoms tended to improve as a result of synchronization without antidepressants...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28008256/blonanserin-treatment-in-patients-with-methamphetamine-induced-psychosis-comorbid-with-intellectual-disabilities
#11
Kosuke Okazaki, Manabu Makinodan, Kazuhiko Yamamuro, Tomoyo Takata, Toshifumi Kishimoto
OBJECTIVE: Methamphetamine (MA) use has recently been associated with high levels of psychiatric hospitalization and serious social dysfunction. MA use causes frequent psychotic symptoms, which can be treated with antipsychotics. However, people with intellectual disabilities (ID) are vulnerable to adverse effects resulting from treatment with antipsychotic medications. METHOD: We report two cases of MA-induced psychosis (MAP) in patients with ID who were treated with the antipsychotic blonanserin...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28003755/neuroprotection-and-acidosis-induced-by-cortical-spreading-depression
#12
COMMENT
Kenneth K Kwong, Suk-Tak Chan
No abstract text is available yet for this article.
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28003754/associations-between-the-mismatch-negativity-component-and-symptom-severity-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder
#13
Kazuhiko Yamamuro, Toyosaku Ota, Junzo Iida, Yoko Nakanishi, Naoko Kishimoto, Toshifumi Kishimoto
AIM: Cognitive impairment is an important predictor of functional outcome in patients with attention deficit/hyperactivity disorder (ADHD). However, the neurophysiology of ADHD-related cognitive impairments remains unclear. Event-related potentials (ERPs) represent the noninvasive measurement of neural correlates of cognitive function. Mismatch negativity (MMN) is an ERP component that is presumed to index the preattentive monitoring of changes in the auditory environment. MATERIALS AND METHODS: Previous studies have shown altered MMN amplitude and latency in patients with ADHD...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28003753/the-impact-of-residual-symptoms-on-relapse-and-quality-of-life-among-thai-depressive-patients
#14
Thanita Hiranyatheb, Daochompu Nakawiro, Tinakon Wongpakaran, Nahathai Wongpakaran, Putipong Bookkamana, Manee Pinyopornpanish, Nattha Saisavoey, Kamonporn Wannarit, Sirina Satthapisit, Sitthinant Tanchakvaranont
PURPOSE: Residual symptoms of depressive disorder are major predictors of relapse of depression and lower quality of life. This study aims to investigate the prevalence of residual symptoms, relapse rates, and quality of life among patients with depressive disorder. PATIENTS AND METHODS: Data were collected during the Thai Study of Affective Disorder (THAISAD) project. The Hamilton Rating Scale for Depression (HAMD) was used to measure the severity and residual symptoms of depression, and EQ-5D instrument was used to measure the quality of life...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28003752/treadmill-exercise-promotes-neuroprotection-against-cerebral-ischemia-reperfusion-injury-via-downregulation-of-pro-inflammatory-mediators
#15
Ying Zhang, Richard Y Cao, Xinling Jia, Qing Li, Lei Qiao, Guofeng Yan, Jian Yang
BACKGROUND: Stroke is one of the major causes of morbidity and mortality worldwide, which is associated with serious physical deficits that affect daily living and quality of life and produces immense public health and economic burdens. Both clinical and experimental data suggest that early physical training after ischemic brain injury may reduce the extent of motor dysfunction. However, the exact mechanisms have not been fully elucidated. The aim of this study was to investigate the effects of aerobic exercise on neuroprotection and understand the underlying mechanisms...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28003751/effect-of-dexmedetomidine-on-hippocampal-neuron-development-and-bdnf-trkb-signal-expression-in-neonatal-rats
#16
Jie Lv, Wei Ou, Xiao-Hua Zou, Yin Yao, Jin-Li Wu
The study aimed to explore the effect of dexmedetomidine (DEX) on hippocampal neuron development process and on molecular expression of brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signaling pathway in neonatal rats. The hippocampal neuron cells were isolated from newborn neonatal rats and cultured in vitro. One control group and three treated groups with 1, 10, and 100 μmol/L DEX were used for the study. Cell activity and apoptosis were detected by the MTT and terminal deoxynucleotidyl transferase-mediated biotinylated uridine triphosphate (UTP) nick end labeling assays...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28003750/baicalein-improves-behavioral-dysfunction-induced-by-alzheimer-s-disease-in-rats
#17
Li Zhou, Sha Tan, Yi-Long Shan, Yu-Ge Wang, Wei Cai, Xue-Hong Huang, Xi-Yuan Liao, Hai-Yan Li, Lei Zhang, Bing-Jun Zhang, Zheng-Qi Lu
BACKGROUND: Alzheimer's disease (AD) is considered to be a neurodegenerative disorder that is characterized by increased oxidative stress. Medicinal plants, with their antioxidant properties, have been used to cure several human diseases. The aim of the current study was to explore the protective and therapeutic effect of baicalein on AD-induced rats. MATERIALS AND METHODS: Swiss Wistar rats were used in the study. The rats were divided into five groups. Group I: normal control group treated with water; Group II: disease control treated with AlCl3 to induce the mimicking AD for 4 successive weeks (SW); Group III: normal control group treated with baicalein (5 mg/kg) for 2 SW followed by combination of baicalein and AlCl3 for 4 SW; Group IV: normal control group treated with baicalein (10 mg/kg) for 2 SW followed by combination of baicalein and AlCl3 for 4 SW; Group V: normal control group treated with rivastigmine (0...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28003749/associations-between-dopamine-d2-receptor-gene-polymorphisms-and-schizophrenia-risk-a-prisma-compliant-meta-analysis
#18
Hairong He, Huanhuan Wu, Lihong Yang, Fan Gao, Yajuan Fan, Junqin Feng, Xiancang Ma
OBJECTIVE: To determine the relationships between dopamine D2 receptor gene polymorphisms and the risk of schizophrenia using meta-analysis. METHOD: The PubMed, Embase, and China National Knowledge Infrastructure databases were searched to identify relevant literature published up to February 2016. The allele contrast model was used. Stata software was used for statistical analysis, with odds ratios (ORs) and 95% confidence intervals (CIs) calculated to evaluate the associations between dopamine D2 receptor gene polymorphisms and the risk of schizophrenia...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27994468/relationship-between-suicide-rate-and-economic-growth-and-stock-market-in-the-people-s-republic-of-china-2004-2013
#19
Honglei Yin, Lin Xu, Yechang Shao, Liping Li, Chengsong Wan
OBJECTIVES: The objective of this study was to estimate the features of suicide rate and its association with economic development and stock market during the past decade in the People's Republic of China. METHODS: Official data were gathered and analyzed in the People's Republic of China during the period 2004-2013. Nationwide suicide rate was stratified by four year age-groups, sex, urban/rural areas, and regions (East, Central, and West). Annual economic indexes including gross domestic product (GDP) per capita and rural and urban income per capita were all adjusted for inflation...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27994467/diminished-autonomic-neurocardiac-function-in-patients-with-generalized-anxiety-disorder
#20
Kyungwook Kim, Seul Lee, Jong-Hoon Kim
BACKGROUND: Generalized anxiety disorder (GAD) is a chronic and highly prevalent disorder that is characterized by a number of autonomic nervous system symptoms. The purpose of this study was to investigate the linear and nonlinear complexity measures of heart rate variability (HRV), measuring autonomic regulation, and to evaluate the relationship between HRV parameters and the severity of anxiety, in medication-free patients with GAD. METHODS: Assessments of linear and nonlinear complexity measures of HRV were performed in 42 medication-free patients with GAD and 50 healthy control subjects...
2016: Neuropsychiatric Disease and Treatment
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