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Neuropsychiatric Disease and Treatment

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https://www.readbyqxmd.com/read/28435276/clinical-and-biochemical-study-of-d-serine-metabolism-among-schizophrenia-patients
#1
Hamdy N El-Tallawy, Tahia H Saleem, Abdallah Maa El-Ebidi, Mohammed H Hassan, Romany H Gabra, Wafaa Ma Farghaly, Nagwa Abo El-Maali, Hoda S Sherkawy
BACKGROUND: Schizophrenia is a typical N-methyl-d-aspartate receptor (NMDA-R) hypofunction disorder. Decreased d-serine (d-Ser) levels in the periphery occur in schizophrenia and may reflect decreased availability of d-Ser to activate NMDA-R in the brain. OBJECTIVE: The objective of this study was to investigate the role of d-Ser metabolism in the pathogenesis of schizophrenia via biochemical assays and correlates, the serum level of d-Ser, d-serine racemase (SR) (responsible for its formation from l-serine [l-Ser]) and d-amino acid oxidase (DAAO) (responsible for its catabolism), among different clinical types of schizophrenia patients...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28435275/pathogenic-beliefs-among-patients-with-depressive-disorders
#2
Adam Neelapaijit, Tinakon Wongpakaran, Nahathai Wongpakaran, Kulvadee Thongpibul
INTRODUCTION: Pathogenic belief is a central construct within control-mastery theory, which is an integrated dynamic-cognitive-relational approach in psychotherapy. Pathogenic beliefs result from traumatic life experiences and are considered the root of any psychological disorders presented clinically. Nevertheless, how and what type of pathogenic beliefs are attributed to clinical depressive disorder is unknown. The present study aimed to examine this issue. PATIENTS AND METHODS: Thirty patients with depressive disorder, who came for psychotherapy at a psychotherapy clinic, were matched based on age and gender with healthy controls who were medical students...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28435274/hashimoto-encephalopathy-with-high-plasma-monoamine-metabolite-levels-a-case-report
#3
Sho Horikoshi, Itaru Miura, Yasuto Kunii, Satoko Asano, Keiko Kanno-Nozaki, Hirobumi Mashiko, Hirooki Yabe
Hashimoto encephalopathy (HE) is believed to be an immune-mediated disorder associated with Hashimoto's thyroiditis. It was suggested that neuropsychiatric symptoms, the presence of antithyroid antibody, and good response to steroids were important for the diagnosis of HE. It has been reported that homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), which are monoamine metabolites of dopamine and noradrenaline, respectively, are the possible biomarkers of neuropsychiatric diseases. We report a case of Hashimoto encephalopathy, in which we longitudinally measured the plasma levels of monoamine metabolites...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28435273/an-innovative-nonpharmacological-intervention-combined-with-intravenous-patient-controlled-analgesia-increased-patient-global-improvement-in-pain-and-satisfaction-after-major-surgery
#4
Chia-Chun Chuang, Chien-Ching Lee, Li-Kai Wang, Bor-Shyh Lin, Wen-Ju Wu, Chung-Han Ho, Jen-Yin Chen
PURPOSE: This study aimed to evaluate whether a nonpharmacological approach through implementation of a communication improvement program (named CICARE for Connect, Introduce, Communicate, Ask, Respond and Exit) into standard operating procedure (SOP) in acute pain service (APS) improved satisfaction in patients receiving intravenous patient-controlled analgesia (IV-PCA). PATIENTS AND METHODS: This was a nonrandomized before-after study. Adult patients (aged between 20 and 80 years) who received IV-PCA after major surgery were included...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28435272/quetiapine-monotherapy-versus-placebo-in-the-treatment-of-children-and-adolescents-with-bipolar-depression-a-systematic-review-and-meta-analysis
#5
REVIEW
Benchalak Maneeton, Suwannee Putthisri, Narong Maneeton, Pakapan Woottiluk, Sirijit Suttajit, Chawanun Charnsil, Manit Srisurapanont
BACKGROUND: Some studies have indicated the efficacy of quetiapine in the treatment of bipolar depression in adult patients. However, its efficacy has been not shown in child and adolescent patients. OBJECTIVE: This systematic review purposefully determined the efficacy and acceptability of quetiapine in the treatment of children and adolescents with bipolar depression. DATA SOURCES: A database search of EMBASE, PubMed, CINAHL, and Cochrane Controlled Trials Register was carried out in March 2016...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28435271/recombinant-human-brain-derived-neurotrophic-factor-prevents-neuronal-apoptosis-in-a-novel-in-vitro-model-of-subarachnoid-hemorrhage
#6
Mingchang Li, Yuefei Wang, Wei Wang, Changlin Zou, Xin Wang, Qianxue Chen
Subarachnoid hemorrhage (SAH) is a hemorrhagic stroke with high mortality and morbidity. An animal model for SAH was established by directly injecting a hemolysate into the subarachnoid space of rats or mice. However, the in vitro applications of the hemolysate SAH model have not been reported, and the mechanisms remain unclear. In this study, we established an in vitro SAH model by treating cortical pyramidal neurons with hemolysate. Using this model, we assessed the effects of recombinant human brain-derived neurotrophic factor (rhBDNF) on hemolysate-induced cell death and related mechanisms...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28435270/relationship-between-hypnosis-and-personality-trait-in-participants-with-high-or-low-hypnotic-susceptibility
#7
Yingchun Zhang, Yunke Wang, Chanchan Shen, Yingying Ye, Si Shen, Bingren Zhang, Jiawei Wang, Wei Chen, Wei Wang
BACKGROUND: The relationship between normal personality and hypnotic susceptibility is important for understanding mental processing and mental disorders, but it is less consistent in normal people or in patients with a psychiatric disorder. We have hypothesized that the correlation exists but varies in individuals with different levels of hypnotizability. PARTICIPANTS AND METHODS: We invited 72 individuals with high (HIGH group) and 47 individuals with low (LOW group) hypnotic susceptibilities to undertake tests of NEO-PI-R and the Stanford Hypnotic Susceptibility Scale, Form C (SHSSC)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28408833/an-internet-based-program-for-depressive-symptoms-using-human-and-automated-support-a-randomized-controlled-trial
#8
Adriana Mira, Juana Bretón-López, Azucena García-Palacios, Soledad Quero, Rosa María Baños, Cristina Botella
PURPOSE: The purpose of this study was to analyze the efficacy of an Internet-based program for depressive symptoms using automated support by information and communication technologies (ICTs) and human support. PATIENTS AND METHODS: An Internet-based program was used to teach adaptive ways to cope with depressive symptoms and daily problems. A total of 124 participants who were experiencing at least one stressful event that caused interference in their lives, many of whom had clinically significant depressive symptoms, were randomly assigned into either an intervention group with ICT support (automated mobile phone messages, automated emails, and continued feedback through the program); an intervention group with ICT support plus human support (brief weekly support phone call without clinical content); or a waiting-list control...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28408832/punding-following-posterior-cerebral-artery-infarction-a-case-report-and-literature-review
#9
Cho-I Lin, Yu-Ching Lin, Wei-Chih Lien, Pei-Chun Hsieh, Sheng-Han Lin, Ta-Shen Kuan
INTRODUCTION: Punding is a complex stereotyped behavior, characterized by excessiveness, non-goal orientation, and repetitiveness. It is mostly associated with Parkinson's disease, and very few cases in non-Parkinson's disease have been reported. We report a case of punding associated with supratentorial ischemic stroke. CASE PRESENTATION: We present a 70-year-old man with left posterior cerebral artery infarction with quetiapine-induced punding manifesting as repetitive unidirectional body turning...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28408831/modulation-of-the-activity-of-n-methyl-d-aspartate-receptors-as-a-novel-treatment-option-for-depression-current-clinical-evidence-and-therapeutic-potential-of-rapastinel-glyx-13
#10
REVIEW
Andrei-Nicolae Vasilescu, Nina Schweinfurth, Stefan Borgwardt, Peter Gass, Undine E Lang, Dragos Inta, Sarah Eckart
Classical monoaminergic antidepressants show several disadvantages, such as protracted onset of therapeutic action. Conversely, the fast and sustained antidepressant effect of the N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine raises vast interest in understanding the role of the glutamate system in mood disorders. Indeed, numerous data support the existence of glutamatergic dysfunction in major depressive disorder (MDD). Drawback to this short-latency therapy is its side effect profile, especially the psychotomimetic action, which seriously hampers the common and widespread clinical use of ketamine...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28408830/twelve-week-physical-exercise-does-not-have-a-long-lasting-effect-on-kynurenines-in-plasma-of-depressed-patients
#11
Vincent Millischer, Sophie Erhardt, Örjan Ekblom, Yvonne Forsell, Catharina Lavebratt
BACKGROUND: Physical exercise has well-characterized positive effects on depressive symptoms. The underlying biologic mechanisms are, however, far from established. A recently discovered mechanism has linked the enhanced conversion of kynurenine to kynurenic acid (KYNA) to an increased resilience toward stress-induced depression in mice. The aim of this study was to translate these findings to humans. MATERIALS AND METHODS: Kynurenine and KYNA levels were measured by high-performance liquid chromatography in plasma samples from 117 patients affected by mild-to-moderate depression before and within a week after a 12-week training period at three different intensities...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28408829/sleep-apnea-and-the-subsequent-risk-of-parkinson-s-disease-a-3-year-nationwide-population-based-study
#12
Ping-Song Chou, Chiou-Lian Lai, Yii-Her Chou, Wei-Pin Chang
PURPOSE: Sleep apnea (SA)-induced chronic intermittent hypoxia increases oxidative stress and inflammation, which may contribute to the pathophysiology of Parkinson's disease (PD). This study evaluated the risk of PD following SA diagnosis. PATIENTS AND METHODS: This was a 3-year nationwide population-based matched cohort study using claims data from the National Health Insurance Research Database (NHIRD), Taiwan. We analyzed 1,944 patients diagnosed as having SA between 1997 and 2005 and a matched cohort of 9,720 non-SA patients from the NHIRD...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28408828/access-to-diagnosis-treatment-and-supportive-services-among-pharmacotherapy-treated-children-adolescents-with-adhd-in-europe-data-from-the-caregiver-perspective-on-pediatric-adhd-survey
#13
Moshe Fridman, Tobias Banaschewski, Vanja Sikirica, Javier Quintero, Kristina S Chen
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common childhood psychiatric disorders and negatively impacts caregivers' lives. Factors including barriers to accessing care, dissatisfaction with support services, and lack of caregiver resources may contribute to this. OBJECTIVES: To report caregivers' experiences of ADHD diagnosis, behavioral therapy (BT), and supportive care for children/adolescents with ADHD. METHODS: The Caregiver Perspective on Pediatric ADHD (CAPPA) survey included caregivers of children/adolescents (6-17 years) from ten European countries who were currently receiving/had received ADHD pharmacotherapy in the previous 6 months...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28392697/comparing-the-ability-of-cognitive-and-affective-theory-of-mind-in-adolescent-onset-schizophrenia
#14
Dandan Li, Xiaosi Li, Fengqiong Yu, Xingui Chen, Long Zhang, Dan Li, Qiang Wei, Qing Zhang, Chunyan Zhu, Kai Wang
BACKGROUND: Evidence in the literature suggests that there is an impairment of social cognition in schizophrenia. Theory of Mind (ToM) is defined as one's ability to understand others' wishes, beliefs, intentions, and other psychological states and thereby to judge others' behavior, as an essential component of social cognition. However, there have been limited studies on social cognition, especially ToM in adolescent onset schizophrenia (AOS). The current study aims to investigate ToM abilities in adolescent schizophrenia according to various ToM subcomponents (cognitive ToM and affective ToM) and various ToM orders (first order and second order)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28392696/compound-porcine-cerebroside-and-ganglioside-injection-attenuates-cerebral-ischemia-reperfusion-injury-in-rats-by-targeting-multiple-cellular-processes
#15
Mingyang Wang, Yi Zhang, Lu Feng, Ji Zheng, Shujie Fan, Junya Liu, Nan Yang, Yanyong Liu, Pingping Zuo
BACKGROUND: Compound porcine cerebroside and ganglioside injection (CPCGI) is a neurotrophic drug used clinically to treat certain functional disorders of brain. Despite its extensive usage throughout China, the exact mechanistic targets of CPCGI are unknown. This study was carried out to investigate the protective effect of CPCGI against ischemic neuronal damage in rats with middle cerebral artery occlusion (MCAO) reperfusion injury and to investigate the neuroprotective mechanisms of CPCGI...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28392695/the-maugeri-stress-index-reduced-form-a-questionnaire-for-job-stress-assessment
#16
Davide Massidda, Ines Giorgi, Giulio Vidotto, Salvatore Tringali, Marcello Imbriani, Paola Baiardi, Giorgio Bertolotti
INTRODUCTION AND OBJECTIVES: A multidimensional self-report questionnaire to evaluate job-related stress factors is presented. The questionnaire, called Maugeri Stress Index - reduced form (MASI-R), aims to assess the impact of job strain on a team or on a single worker by considering four domains: wellness, resilience, perception of social support, and reactions to stressful situations. MATERIAL AND METHODS: The reliability of a first longer version (47 items) of the questionnaire was evaluated by an internal consistency analysis and a confirmatory factor analysis...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28367056/association-study-of-mif-promoter-polymorphisms-with-suicide-completers-in-the-japanese-population
#17
Naofumi Shimmyo, Akitoyo Hishimoto, Ikuo Otsuka, Satoshi Okazaki, Shuken Boku, Kentaro Mouri, Tadasu Horai, Motonori Takahashi, Yasuhiro Ueno, Osamu Shirakawa, Ichiro Sora
BACKGROUND: Numerous studies suggest that inflammation plays a key role in suicidal behavior. Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has received increasing attention in depression research. However, no study has investigated whether MIF has genetic involvement in completed suicide. In this study, we sought to explore the relationship between two functional polymorphisms on the MIF gene promoter (MIF-794CATT5-8 microsatellite and MIF-173G/C single-nucleotide polymorphism [SNP]) and completed suicide by using one of the largest samples of suicide completers ever reported...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28367055/multicenter-open-label-exploratory-clinical-trial-with-rhodiola-rosea-extract-in-patients-suffering-from-burnout-symptoms
#18
Siegfried Kasper, Angelika Dienel
PURPOSE: This study is the first clinical trial aiming to explore the clinical outcomes in burnout patients treated with Rhodiola rosea. The reported capacity of R. rosea to strengthen the organism against stress and its good tolerability offer a promising approach in the treatment of stress-related burnout. The aim of the treatment was to increase stress resistance, thus addressing the source rather than the symptoms of the syndrome and preventing subsequent diseases associated with a history of burnout...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28360524/antistress-effects-of-kampo-medicine-yokukansan-via-regulation-of-orexin-secretion
#19
Haruto Katahira, Masataka Sunagawa, Daishi Watanabe, Yasuaki Kanada, Ayami Katayama, Risa Yamauchi, Masashi Takashima, Shintaro Ishikawa, Tadashi Hisamitsu
OBJECTIVE: Various stressors induce stress responses through the hypothalamic-pituitary-adrenal and the sympathetic-adrenal-medullary axes, which are regulated, in part, by orexin. For example, secretion of orexin in the hypothalamus is increased in rats exposed to the stress of social isolation for 1 week. In this study, the antistress effects of Kampo medicine Yokukansan (YKS) via the regulation of orexin secretion were investigated using a rat model. METHODS AND RESULTS: The administration of 300 mg/kg per day of YKS to rats for 1 week significantly decreased the plasma orexin levels compared with non-treated rats, whereas the administration of 1,000 mg/kg of YKS had no effect on orexin levels...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28360523/type-d-personality-as-a-predictor-of-self-efficacy-and-social-support-in-patients-with-type-2-diabetes-mellitus
#20
Yechang Shao, Honglei Yin, Chengsong Wan
OBJECTIVE: The aim of this study was to estimate the prevalence of Type D personality and assess the relationship between this personality type and self-efficacy/social support in Chinese patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: From January 1, 2014, to July 31, 2014, 532 consecutive patients with T2DM were recruited from two hospitals in Guangzhou, China. The participants completed questionnaires containing questions about sociodemographic characteristics, Type D personality, self-efficacy, and social support scales, and their medical records were reviewed for additional data...
2017: Neuropsychiatric Disease and Treatment
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