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Neuropsychiatric Disease and Treatment

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https://www.readbyqxmd.com/read/29138569/post-marketing-observational-program-of-the-effectiveness-of-fluvoxamine-for-the-treatment-of-depression-in-patients-with-neurological-disorders-the-friends-study
#1
Nikolay N Yahno, Anastasia V Fedotova
In a prospective, non-blinded, uncontrolled, multicenter, post-marketing, observational study (FRIENDS; NCT02043197), fluvoxamine (50-300 mg/day for 90 days) was effective for the treatment of depression in 299 adult patients (age ≥18 years) with neurological disorders at baseline. The therapeutic effect of fluvoxamine was measured by means of changes in the Hospital Anxiety and Depression Scale depression and anxiety scores (HADS-D and HADS-A, respectively), global severity of illness, and clinical condition (measured using the Clinical Global Improvement [CGI] scale)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29138568/epidemiology-and-costs-of-multiple-sclerosis-in-switzerland-an-analysis-of-health-care-claims-data-2011-2015
#2
Eva Blozik, Roland Rapold, Klaus Eichler, Oliver Reich
Background: Medical therapy for multiple sclerosis (MS) is expensive. Quantifying the burden of MS is fundamental for health-care planning and the allocation of resources for the management of MS. This study provides current national estimates of prevalence, incidence, mortality, and costs of MS in Switzerland using claims data between 2011 and 2015. Methods: We analyzed health insurance claims of adult persons enrolled with a large health insurance group covering about 13% of the Swiss population between 2011 and 2015...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29138567/resveratrol-ameliorates-chronic-unpredictable-mild-stress-induced-depression-like-behavior-involvement-of-the-hpa-axis-inflammatory-markers-bdnf-and-wnt-%C3%AE-catenin-pathway-in-rats
#3
Xin-Hua Yang, Su-Qi Song, Yun Xu
Classic antidepressant drugs are modestly effective across the population and most are associated with intolerable side effects. Recently, numerous lines of evidence suggest that resveratrol (RES), a natural polyphenol, possesses beneficial therapeutic activity for depression. The aim of the present study was to explore whether RES exhibits an antidepressant-like effect in a depression model and to explore the possible mechanism. A depression model was established via chronic unpredictable mild stress (CUMS), after which the model rats in the RES and fluoxetine groups received a daily injection of RES or fluoxetine, respectively...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29123404/effects-of-dopaminergic-drug-adjustment-on-executive-function-in-different-clinical-stages-of-parkinson-s-disease
#4
Hidetomo Murakami, Tetsuhito Nohara, Hidenobu Shozawa, Yoshiyuki Owan, Takeshi Kuroda, Satoshi Yano, Machiko Kezuka, Mitsuru Kawamura, Kenjiro Ono
Background: Effects of dopaminergic medication on executive function in patients with Parkinson's disease (PD) are inconsistent. Objective: We examined the effect of dopaminergic medication on executive function in 24 drug-naïve PD patients (de novo group) and in 21 PD patients on chronic dopaminergic medication (chronic medication group). Methods: PD patients without dementia were included in this study. For the de novo group patients, dopaminergic medication was initiated, and the dose was increased to improve motor symptoms...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29123403/effects-of-short-term-piano-training-on-measures-of-finger-tapping-somatosensory-perception-and-motor-related-brain-activity-in-patients-with-cerebral-palsy
#5
Ana Alves-Pinto, Stefan Ehrlich, Gordon Cheng, Varvara Turova, Tobias Blumenstein, Renée Lampe
Playing a musical instrument demands the integration of sensory and perceptual information with motor processes in order to produce a harmonic musical piece. The diversity of brain mechanisms involved and the joyful character of playing an instrument make musical instrument training a potential vehicle for neurorehabilitation of motor skills in patients with cerebral palsy (CP). This clinical condition is characterized by motor impairments that can affect, among others, manual function, and limit severely the execution of basic daily activities...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29123402/transient-global-amnesia-current-perspectives
#6
REVIEW
David R Spiegel, Justin Smith, Ryan R Wade, Nithya Cherukuru, Aneel Ursani, Yuliya Dobruskina, Taylor Crist, Robert F Busch, Rahim M Dhanani, Nicholas Dreyer
Transient global amnesia (TGA) is a clinical syndrome characterized by the sudden onset of an extraordinarily large reduction of anterograde and a somewhat milder reduction of retrograde episodic long-term memory. Additionally, executive functions are described as diminished. Although it is suggested that various factors, such as migraine, focal ischemia, venous flow abnormalities, and epileptic phenomena, are involved in the pathophysiology and differential diagnosis of TGA, the factors triggering the emergence of these lesions are still elusive...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29123401/psychosocial-intervention-for-patients-with-type-2-diabetes-mellitus-and-comorbid-depression-a-meta-analysis-of-randomized-controlled-trials
#7
Jing Xie, Wuquan Deng
Background: The efficacy of psychosocial intervention has been proven in treatment of diabetic patients with depression in some studies. This meta-analysis was conducted to explore the efficacy as well as additional effects of this method during diabetic management in patients with type 2 diabetes mellitus (T2DM) and comorbid depression. Methods: Electronic databases were searched from March 2000 to March 2017 for randomized controlled trials (RCTs) studying the effects of psychosocial intervention on T2DM patients with depression...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29123400/comparison-of-spontaneous-brain-activity-revealed-by-regional-homogeneity-in-aqp4-igg-neuromyelitis-optica-optic-neuritis-versus-mog-igg-optic-neuritis-patients-a-resting-state-functional-mri-study
#8
Junqing Wang, Yuan Tian, Yi Shao, Hui Feng, Limin Qin, Weiwei Xu, Hongjuan Liu, Quangang Xu, Shihui Wei, Lin Ma
Objective: Many previous studies have demonstrated that neuromyelitis optica (NMO) patients have abnormalities of brain anatomy and function. However, differences in spontaneous brain activity between myelin oligodendrocyte glycoprotein (MOG)-IgG ON and aquaporin 4(AQP4)-neuromyelitis optica-optic neuritis (ON) remain unknown. In the current study, we investigated the brain neural homogeneity in MOG-IgG ON versus AQP4-IgG NMO-ON subjects by regional homogeneity (ReHo) method using magnetic resonance imaging (MRI)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29118582/association-of-tnf-alpha-g-308a-gene-polymorphism-with-depression-a-meta-analysis
#9
Kwang-Hee Shin, Hyeon Cheol Jeong, Dong-Hee Choi, Sung Nyun Kim, Tae-Eun Kim
Background: Although many studies have investigated the association of a single nucleotide polymorphism in TNF-α G-308A gene with depression, their association is still controversial. To clarify this, we performed a meta-analysis. Method: Studies related to TNF-α G-308A and depression were retrieved from PubMed, Medline, Embase, and Scopus (up to April 18, 2017). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in the models of allele comparison (G vs A), homozygote comparison (GG vs AA), dominant (GG vs GA + AA), and recessive (GG + GA vs AA) to estimate the strength of the associations...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29118581/complexity-and-wide-range-of-neuromyelitis-optica-spectrum-disorders-more-than-typical-manifestations
#10
REVIEW
Jinming Han, Meng-Ge Yang, Jie Zhu, Tao Jin
Neuromyelitis optica (NMO), considered to be mediated by autoantibodies, often cause severely disabling disorders of the central nervous system, and predominantly cause optic nerve damage and longitudinally extensive transverse myelitis. Remarkable progress has been made in deciphering NMO pathogenesis during the past decade. In 2015, the International Panel for NMO Diagnosis proposed the unifying term "NMO spectrum disorders" (NMOSD) and the updated NMOSD criteria reflects a wide range of disease and maintains reasonable specificity...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29089771/a-multicenter-open-label-pilot-study-evaluating-the-functionality-of-an-integrated-call-center-for-a-digital-medicine-system-to-optimize-monitoring-of-adherence-to-oral-aripiprazole-in-adult-patients-with-serious-mental-illness
#11
Alex Kopelowicz, Ross A Baker, Cathy Zhao, Claudette Brewer, Erica Lawson, Timothy Peters-Strickland
BACKGROUND: Medication nonadherence is common in the treatment of serious mental illness (SMI) and leads to poor outcomes. The digital medicine system (DMS) objectively measures adherence with oral aripiprazole in near-real time, allowing recognition of adherence issues. This pilot study evaluated the functionality of an integrated call center in optimizing the use of the DMS. MATERIALS AND METHODS: An 8-week, open-label, single-arm trial at four US sites enrolled adults with bipolar I disorder, major depressive disorder, and schizophrenia on stable oral aripiprazole doses and willing to use the DMS (oral aripiprazole + ingestible event marker [IEM], IEM-detecting skin patch, and software application)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29089770/bupropion-interferes-with-the-image-diagnosis-of-parkinson-s-disease
#12
Chieh-Hsin Lin, Hsien-Yuan Lane
Major depressive disorder (MDD) and Parkinson's disease (PD) share symptoms such as tremor. Bupropion, a norepinephrine-dopamine reuptake inhibitor, shows weak dopamine transporter (DAT) occupancy. We report here on a patient with MDD whose hand tremors might have been misdiagnosed as PD by single-photon emission computed tomography (SPECT) under bupropion use. A 66-year-old male patient with MDD had been receiving bupropion 150 mg per day for 6 months. His mood symptoms improved partially with bupropion treatment, however, hand tremors persisted...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29089769/identification-of-a-novel-cacna1a-mutation-in-a-chinese-family-with-autosomal-recessive-progressive-myoclonic-epilepsy
#13
Yudan Lv, Zan Wang, Chang Liu, Li Cui
BACKGROUND: Progressive myoclonic epilepsy (PME) is a heterogeneous neurodegenerative disorder, which is commonly manifested with refractory seizures and neurologic deterioration. The prognosis of PME is poor, so early diagnosis of PME is critical. The aim of our study is to identify the novel pathogenic gene in a Chinese family with PME, which may be helpful in future. SUBJECTS AND METHODS: A three-generation consanguineous Chinese Han family with PME was recruited...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29089768/differences-in-serum-zinc-levels-in-acutely-ill-and-remitted-adolescents-and-young-adults-with-bulimia-nervosa-in-comparison-with-healthy-controls-a-cross-sectional-pilot-study
#14
Florian D Zepf, Pradeep Rao, Kevin Runions, Richard M Stewart, Julia K Moore, Janice Wy Wong, Maike Linden, Idil Sungurtekin, Franziska Glass, Linda Gut, Dirk Peetz, Gudrun Hintereder, Michael Schaab, Fritz Poustka, Lars Wöckel
BACKGROUND: Research has implicated that changes in zinc (Zn) metabolism may be associated with the biological underpinnings of eating disorders, in particular anorexia nervosa. However, to date research on the role of Zn in patients with bulimia nervosa (BN) is scarce. OBJECTIVE: We aimed to explore serum Zn concentrations in young patients with BN, with a focus on the stage of the disorder, comparing acutely ill and recovered patients with BN with healthy controls...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29089767/thalamo-cortical-network-underlying-deep-brain-stimulation-of-centromedian-thalamic-nuclei-in-intractable-epilepsy-a-multimodal-imaging-analysis
#15
Seong Hoon Kim, Sung Chul Lim, Dong Won Yang, Jeong Hee Cho, Byung-Chul Son, Jiyeon Kim, Seung Bong Hong, Young-Min Shon
OBJECTIVE: Deep brain stimulation (DBS) of the centromedian thalamic nucleus (CM) can be an alternative treatment option for intractable epilepsy patients. Since CM may be involved in widespread cortico-subcortical networks, identification of the cortical sub-networks specific to the target stimuli may provide further understanding on the underlying mechanisms of CM DBS. Several brain structures have distinguishing brain connections that may be related to the pivotal propagation and subsequent clinical effect of DBS...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29075121/coping-schemas-and-cardiovascular-risks-study-protocol
#16
Milos Slepecky, Antonia Kotianova, Jan Prasko, Ivan Majercak, Erika Gyorgyova, Michal Kotian, Marta Zatkova, Ingrid Tonhajzerova, Michaela Chupacova, Marta Popelkova
The aim of this article is to describe the protocol of a trial focusing on the psychological, anthropometric, cardiac, and psychophysiological factors contributing to increased risk of cardiovascular diseases (CVDs). As background, the article provides a short overview of research literature linking personal traits, maladaptive schemas, and coping styles with CVDs through reactivity of the autonomic nervous system.
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29075120/relationship-of-negative-and-positive-core-beliefs-about-the-self-with-dysfunctional-attitudes-in-three-aspects-of-life
#17
Koichi Otani, Akihito Suzuki, Yoshihiko Matsumoto, Toshinori Shirata
OBJECTIVE: Cognitive theory assumes a pivotal role of negative core beliefs about the self in dysfunctional attitudes predisposing to depression. Meanwhile, the role of positive core beliefs about the self in cognitive vulnerability to depression is unknown. Therefore, we examined the relationship of negative and positive core beliefs about the self with dysfunctional attitudes in three aspects of life. METHODS: The subjects were 311 Japanese volunteers. Core beliefs of negative-self and positive-self were evaluated by the corresponding subscales of the Brief Core Schema Scales...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29075119/factors-associated-with-bullying-victimization-among-korean-adolescents
#18
Hye-Jin Seo, Young-Eun Jung, Moon-Doo Kim, Won-Myong Bahk
OBJECTIVES: The aims of the present study were to assess the prevalence of bullying victimization among Korean adolescents by sex and age and to investigate the correlates of this phenomenon. METHODS: Of 3,200 eligible subjects, 2,936 (91.8%) adolescents were recruited from four elementary schools (6th grade, age range: 10-12 years), five middle schools (8th grade, age range: 13-14 years), and three high schools (10th grade, age range: 15-17 years) located in the Jeju Special Self-Governing Province, Republic of Korea...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29075118/the-comorbidity-of-bipolar-disorder-diabetes-mellitus-and-autoimmune-hypothyroidism-in-an-adult-woman-with-turner-s-syndrome-a-case-report
#19
Jinling Li, Xiaohong Hong, Haiyun Xu
Turner's syndrome (TS) is the most common sex chromosome abnormality in females and characterized with short stature and ovarian dysgenesis. Patients with TS may also present many other physical diseases and mental disorders. In this case report, we present a 49-year-old woman with TS, who also met criteria for bipolar disorder, type 2 diabetes mellitus, and autoimmune hypothyroidism. The patient was admitted to the mental health center for depressive symptoms in 1991 and was misdiagnosed as hypopituitarism, which was not corrected until 2005 when her karyotype of 45, X/46, X, i(Xq) was identified...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29075117/need-for-medication-to-complement-catecholamines-in-smoking-cessation-of-hardcore-smokers
#20
Atsuko Kawai, Masatake Kurita, Satoshi Nishino, Eishin Hirata, Tadahiro Sato, Yoshiro Okubo
Many smokers find it difficult to stop smoking without assistance. The antidepressants bupropion and nortriptyline can aid smoking cessation. The main aim of this study was to understand the pathophysiology of smoking cessation better based on biological backgrounds. We investigated the following biological markers for any alterations during smoking cessation in the absence of pharmacotherapy: the dopamine metabolite homovanillic acid (HVA), the noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) and brain-derived neurotrophic factor (BDNF)...
2017: Neuropsychiatric Disease and Treatment
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