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Current Pediatric Reviews

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https://www.readbyqxmd.com/read/28215177/cutaneous-changes-in-neonates-in-the-first-72-hours-of-birth-an-observational-study
#1
Nayantara R Gandra, Harshita B Reddy, Tina P Katta
BACKGROUND: Variation in neonatal skin changes and presentation is a frequent occurrence. We studied the pattern of cutaneous manifestations in new-borns <72 hours of birth. METHOD: We included all live babies delivered in our hospital; Babies were categorised according to age, birth weight and gestational age. Neonates were examined within 24 hrs of birth and daily for skin lesions for 72 hrs. Skin lesions were categorised into physiological, transient eruptions, due to infections, congenital anomalies and miscellaneous...
February 16, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28215176/the-comparison-the-serum-strem1-levels-between-children-with-upper-and-lower-uti
#2
Samileh Noorbakhsh, Fahime Ehsanipour, Vida Zarabi, Zahra Movahedi, Nahid Rahimzadeh
Back ground: UTI is a common and important clinical problem in Iranian children which is often difficult on clinical grounds. Distinguishing the upper UTI from lower UTI is very important for clinician. The aim of this study was to determine the usefulness of serum STREM-1 level in patients with UTI to find out if it can use for distinguishing upper UTI from lower UTI or not. METHODS: In this prospective cross sectional study (2010-2011) we compared the serum level of STREM-1 (pg. /ml) in 36 proven UTI cases (24 upper and 12 lower UTI ) with 25 normal children (without UTI) in Rasoul Akram hospital Tehran, Iran...
February 16, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28117009/update-on-predicting-severe-hyperbilirubinemia-and-bilirubin-neurotoxicity-risks-in-neonates
#3
Pearl W Chang, Thomas B Newman, M Jeffrey Maisels
Extreme hyperbilirubinemia and kernicterus, though rare, continue to occur despite the adoption of universal screening. Unless they are known to have glucose-6-phosphate dehydrogenase deficiency, infants who currently develop kernicterus in high resource countries are often otherwise healthy newborns discharged from the well-baby nursery. In this review, we highlight risk factors that increase the risk of a newborn ≥35 weeks gestational age developing severe hyperbilirubinemia, as well as the risk factors that increase the hyperbilirubinemic infant's risk of kernicterus...
January 23, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28088898/metabolomic-shifts-following-play-based-activity-in-overweight-preadolescents
#4
Marco Meucci, Carlo Baldari, Laura Guidetti, Jessica Renee Alley, Caorl Cook, Collier Robert Scott
BACKGROUND: Play-based activities can be a positive intervention to increase participation of overweight children. Metabolomics can reveal elemental shifts in the metabolome, lending potential mechanistic explanations behind improvements in physiological systems. OBJECTIVES: To elucidate dose-response urinary metabolomic signature shifts in overweight preadolescents following four or eight weeks of supervised play-based activity versus a typical summer break control group...
January 13, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28071585/newborn-bilirubin-screening-for-preventing-severe-hyperbilirubinemia-and-bilirubin-encephalopathy-a-rapid-review
#5
Kalpana Bhardwaj, Tiffany Locke, Anne Biringer, Allyson Booth, Elizabeth Kathleen Darling, Shelley Dougan, Jane Harrison, Stephen Hill, Ana Johnson, Susan Makin, Beth Potter, Thierry Lacaze-Masmonteil, Julian Little
hyperbilirubinemia [2], every newborn should be assessed for the risk of developing severe hyperbilirubinemia with the help of predischarge total serum bilirubin or transcutaneous bilirubin measurements and/or assessments of clinical risk factors. The aim of this rapid review is 1) to review the evidence for 1) predicting and preventing severe hyperbilirubinemia and bilirubin encephalopathy, 2) determining the efficacy of home/community treatments (home phototherapy) in the prevention of severe hyperbilirubinemia, and 3) non-invasive/transcutaneous methods for estimating serum bilirubin level...
January 10, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28034356/improving-cancer-care-for-children-in-the-developing-world-challenges-and-strategies
#6
Zakiya Al Lamki
Cancer is a global health problem particularly in developing countries where the burden of cancer is ever increasing and claiming the lives of about 100,000 children under the age of 15 years every year. Majority of these occur in the Low and Middle Income Countries (LMICs) where 90% of world children live. Contributing factors to this trend is the reduction of communicable diseases and emergence of new infections, improvement of nutrition and socio-economic conditions, industrialization and urbanization. However, due to its complexity, childhood cancer is given the least priority by the governments' funding...
December 30, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27978785/the-five-pediatric-cancers-update-on-genetic-implications
#7
Stacy Cooper, Jeffrey Rubens, Joann Bodurtha
Pediatric cancer has undergone significant improvements in survival over the past several decades, in part due to a better understanding of the underlying genetic aberrations of each oncologic diagnosis, which has allowed for more effective targeted therapies. Pediatric brain tumors, leukemia, lymphoma, Wilms tumor, and retinoblastoma are exemplary pediatric cancers that each have specific epidemiology regarding children at risk as well as characteristic associated genetic lesions. These genetic features are more commonly being used to provide risk stratification, as well as to identify novel pathways for targeted therapy...
December 13, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27978786/the-price-of-the-successful-treatment-of-pediatric-malignancies
#8
Myriam Weyl-Ben-Arush
An estimated 175,000 cases of cancer are diagnosed annually in children younger than 15 years of age worldwide, and fewer than 40% of them, mostly in high-income countries, are adequately diagnosed and treated. A child's probability of surviving cancer is poor in less developed countries, and extreme discomfort is likely in the absence of palliative care1.
December 12, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27917707/management-of-pneumonia-in-the-pediatric-critical-care-unit-an-area-for-antimicrobial-stewardship
#9
Aimee M Dassner, David P Nicolau, Jennifer E Girotto
Pediatric pneumonia is one of the most common causes of childhood infection requiring hospitalization and is a substantial driver of antimicrobial use among hospitalized children. About 12-20% of pediatric patients hospitalized with community-acquired pneumonia (CAP) require critical care. Additionally, nosocomial pneumonias (i.e. hospital-acquired and ventilator-associated pneumonias) are responsible for 15-53% of hospital-associated infections and are the most common indication for empiric antibiotics in the pediatric intensive care unit...
December 4, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27848890/the-impact-of-cancer-and-its-treatment-on-the-growth-and-development-of-the-pediatric-patient
#10
Sarah Brand, Joanne Wolfe, Chase Samsel
While pediatric survival rates have increased over the past 40 years, it has been well established that cancer and its treatment significantly impact children and their families. For the majority of families, a child's cancer diagnosis and treatment is the most difficult life experience they will face. While most families adjust to this significant stressor, there is no doubt that coping with the treatment process is an extremely difficult experience with multiple psychosocial consequences (Liptak, Zelter, & Recklitis, 2015)...
November 15, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27848889/contemporary-pediatric-palliative-care-myths-and-barriers-to-integration-into-clinical-care
#11
Stefan J Friedrichsdorf
At least 20 million children would benefit from Pediatric Palliative Care (PPC) annually, and 8 million children would need specialized PPC services. In the USA alone, more than 42,000 children 0-19 years died in 2013, fifty-five percent of them infants younger than 1 year. This article aims to critically review eight common assumptions, myths and barriers, which may hinder the implementation of PPC into the care of a child with advanced serious illnesses. Interdisciplinary PPC is about matching treatment to patient goals and is considered specialized medical care for children with serious illness...
November 15, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27848891/second-malignant-neoplasms-in-childhood-cancer-survivors
#12
Rejin Kebudi, Gül Nihal Özdemir
The survival of children with cancer have improved dramatically in the last decades. Survivors of childhood cancer are at increased risk of long-term complications of therapeutic exposure. Second malignant neoplasms are one of the most severe side effects of cancer treatment. The frequency and type of secondary cancers may vary depending on the initial diagnosis, treatment administered and genetic predisposition. This review highlights the risk factors in the development of SMNs in survivors of pediatric cancers and their differences according to primary cancer type, genetic predisposition and treatment admistered...
November 14, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27834132/surgical-management-of-medullary-thyroid-carcinoma-in-pediatric-age
#13
Claudio Spinelli, Leonardo Rossi, Silvia Strambi, Jessica Piscioneri, Rossella Elisei, Maura Massimino, Paolo Miccoli
Medullary thyroid carcinoma (MTC) is a rare, accounting for 5% of thyroid malignancies. It is a neuroendocrine tumor wich origins from thyroid parafollicular cells. It may be sporadic, mostly in adult patients, or inherited as autosomal dominant pattern, mostly in pediatric patients. As familial cancer, MTC may presented isolated as familial medullary thyroid carcinoma (FMTC) - 10% of cases - or, most often, as part of multiple endocrine neoplasm type 2 (MEN 2A or MEN 2B) syndromes - 90% of cases. The therapy for sporadic or hereditary MTC is surgical resection and consists in total thyroidectomy associated with central compartment lymph nodal dissection; the radicality of this intervention is fundamental to obtain a definitive cure...
November 11, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27804857/histopathology-immunohistochemistry-and-molecular-biology-of-follicular-epithelium-derived-pediatric-thyroid-carcinomas
#14
Claudio Spinelli, Paola Collini, Marta Barisella, Angela Greco
Thyroid carcinomas derived from the follicular epithelium are rare in children up to 18 years of age. While the morphological features are superimposable in children and adults, the age at onset is relevant to both the frequency of histotypes and variants, and to their biologic behaviour. Papillary carcinomas (PCs) represent more than 90% of cases. Follicular carcinomas (FCs) rarely occur, and they are mostly represented by minimally invasive (encapsulated) FCs (MIFCs). Poorly differentiated carcinomas (PDCs) are very rare, while anaplastic (undifferentiated) carcinomas are practically nonexistent...
November 1, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27804856/a-papillary-thyroid-carcinoma-in-pediatric-age-an-example-of-a-rare-tumour-managed-within-a-cooperative-comprehensive-project
#15
Claudio Spinelli, Maura Massimino, Giovanna Sironi, Andrea Ferrari, Marta Podda, Stefano Chiaravalli
Though rare in childhood, thyroid cancers represent the most frequent tumours of endocrine glands in childhood and adolescence. Papillary thyroid carcinoma is a non-medullary, follicular-derived differentiated tumour of the thyroid. There is still controversy concerning the therapeutic approach of PTCs in the paediatric population; regarding which should be the extent of the surgical approach, and the need for radioactive iodine (RAI) therapy. The cooperative TREP project (Tumori Rari in Età Pediatrica [Rare Tumours in Paediatric Age]) was launched in Italy in 2000 (under the patronage of AIEOP - Associazione Italiana Ematologia Oncologia Pediatrica) with a view to improving both research the clinical management on the less common paediatric cancers...
October 31, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27804855/the-thyroid-ultrasound-and-other-imaging-procedures-in-the-pediatric-age
#16
Claudio Spinelli, Federica Guidoccio, Mariano Grosso
The purpose of this review is to provide a reappraisal of the diagnostic imaging procedures for thyroid carcinoma in pediatric patients, including thyroid ultrasound (US), ultrasound-guided fine-needle aspiration biopsy (FNAB), scintigraphy, radiological techniques (CT, MR), and PET/CT. The most frequent indication for thyroid imaging is characterization of a palpable mass in the neck or thyroid gland. Thyroid US is a first-line examination for visualizing the thyroid gland as it provides anatomic and perfusion information; on the other hand, scintigraphy mostly provides functional information but combined with some anatomic information as well...
October 31, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27745544/pediatric-differentiated-thyroid-cancer-when-to-perform-conservative-and-radical-surgery
#17
Claudio Spinelli
Thyroid tumors affect all age groups, including children and adolescents. Malignant cancer of the thyroid is a relatively uncommon disease in pediatric age. In the recent decades the incidence of paediatric differentiated thyroid carcinoma (DTC) has increased. DTC in paediatric age is rare and has an excellent prognosis. Compared to adult counterpart, DTC in childhood presents some different features as follows: larger volume at the diagnosis, more frequent multicentricity (both mono- and bilateral), earlier local involvement of soft tissue of the neck, earlier lymph node involvement, distant metastases 3-4 times more frequent (most often in the lungs and almost always functional) and more common post-operatory recurrence; nevertheless, the prognosis of DTC in childhood is better and the survival greater than in adult...
October 13, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27634538/child-abuse-and-neglect-a-review-of-the-literature
#18
Pietro Ferrara, Chiara Guadagno, Annamaria Sbordone, Maria Amato, Giulia Spina, Giacomo Perrone, Maria Cristin Basile, Francesca Ianniello, Giovanna Carmela Fabrizio, Massimo Pettoello-Mantovani, Alberto Verrotti, Alberto Villani, Giovanni Corsello
Child maltreatment is a complex life experience happening when a parent or caregiver does an intentional or potential damage to a child, including acts of commission and omission. Child abuse is not an uncommon event, but it is not always recognized. Identifying the real number of maltreated children is a challenge because of the large variability in reported prevalence data across studies. Unfortunately, in the United States, it affects 1 in 8 children, by the age of 18 years, annually. Paediatricians may encounter a variety of forms of maltreatment such as neglect, emotional, physical and sexual abuse...
September 14, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27539311/dysfunctional-voiding-in-pediatrics-a-review-of-pathophysiology-and-current-treatment-modalities
#19
María Fernández-Ibieta
In Dysfunctional Voiding (DV), the patient contracts the external urethral sphincter or pelvic diaphragm (consisting of striated muscle) during voiding, contrary to normal physiological mechanism. In Flowmetry plus pelvic Electromyography (EMG), the perineal surface electrodes will show a persistent activity during voiding. The cause is believed to be the persistence of an immature bladder control. The overall prevalence of DV is estimated between 7 and 11% of girls of school age. Symptoms of DV comprises a range of symptoms, deriving from outlet obstruction, incomplete voiding and elevated Post Micturition Residual (PMR): from daytime urine leaks, nocturnal enuresis, Urinary Tract Infections (UTI), or Vesicoureteral reflux (VUR), to the final decompensation of upper urinary tract in extreme cases...
August 16, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27357084/long-term-complications-in-pediatric-liver-transplant-recipients-what-every-pediatrician-should-know
#20
Dalia Youssef, Azfar Niazi, Naim Alkhouri
The outcomes of liver transplantation in the pediatric population have improved significantly over the past two decades. As long-term survival improves, potential complications related to immunosuppression, delayed growth and development, and metabolic issues have started to be seen more commonly in long-term survivors. Hence, general pediatricians should to be aware of these potential complications in order to optimize the medical care and the quality of life for children with liver transplantation.
June 27, 2016: Current Pediatric Reviews
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