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Current Hypertension Reviews

Mehdi Jafari Oori, Farahnaz Mohammadi, Kian Norozi, Masoud Fallahi Khoshknab, Abbas Ebadi, Reza Ghanei
INTRODUCTION: prevalence of hypertension (HTN) is increasing in the developing countries like Iran. Various studies have reported different rates of HTN in Iran. The purpose of this study was to estimate an overall prevalence of HTN in Iran. METHODOLOGY: Using the English and Persian key derived from Mesh, the databases including MagIran, Iran Medex, SID, Web of Sciences, PubMed, Science Direct and Google Scholar as a searching engine were reviewed: from 2004 to 2018...
January 18, 2019: Current Hypertension Reviews
Dalton Valentim Vassallo, Giulia Alessandra Wiggers, Alessandra Simão Padilha, Maylla RonacherSimões
The use of heavy metals is closely linked to the history of mankind. They have been used as important materials in a wide variety of human activities such as manufacturing utensils and tools. Such extended use has significantly increased professional and environmental exposure to mercury, lead and cadmium. These metals are known to produce hypertension in humans and animals and, among other effects, they can also affect endothelial function. Results described here suggest that mercury, lead and cadmium affect vascular reactivity, even at low doses or concentrations...
January 15, 2019: Current Hypertension Reviews
Leandro Bueno Bergantin
BACKGROUND: Depression and hypertension are medical problems both with clearly restricted pharmacotherapies, along with a high prevalence around the world. In fact, an intensive discussion in the field is that a dysregulation of the intracellular Ca2+ homeostasis (e.g. excess of intracellular Ca2+) contributes to the pathogenesis of both hypertension and depression. Furthermore, depression rises the risk of hypertension incidence. Indeed, several data support the concept that depression is an independent risk issue for hypertension...
January 15, 2019: Current Hypertension Reviews
Naina Kumar, Amit K Singh
OBJECTIVE: Assess the relationship between maternal serum uric acid and severity of Hypertensive disorders of pregnancy in a rural tertiary care centre. MATERIALS AND METHODS: Present study was conducted in Obstetrics and Gynaecology department of rural tertiary care centre of Northern India over seven months (October 2016-May 2017) on 110 women admitted with a Hypertensive disorder of pregnancy (Gestational hypertension, Pre-eclampsia, Eclampsia) at ≥34 weeks gestation...
November 12, 2018: Current Hypertension Reviews
Maurilio Tiradentes Dutra, Karla Gonalves Martins, Diego Batista Vieira Dos Reis, Alessandro de Oliveira Silva, Márcio Rabelo Mota
BACKGROUND: Anthropometric indices are useful to identify excess weight and poor health outcomes. Previous research showed that some indices are correlated to blood pressure (BP) among adults. Yet, this associations are poorly characterized in women with sarcopenic obesity (SO). SO is characterized as the combination of sarcopenia and obesity and has been examined as an emerging cause of disorders and frailty. OBJECTIVE: to examine the association between anthropometric indices and BP in community dwelling women with and without SO...
October 31, 2018: Current Hypertension Reviews
Beihua Zhong, Shuangtao Ma, Donna H Wang
Background-This study tested the hypothesis that genetically ablation of transient receptor potential vanilloid type 1 (TRPV1) exacerbates impairment of baroreflex in mice fed a western diet (WD) and leads to distinct diurnal and nocturnal blood pressure patterns. Methods-TRPV1 gene knockout (TRPV1-/-) and wild-type (WT) mice were given a WD or normal diet (CON) for 4 months. Results-Capsaicin, a selective TRPV1 agonist, increased ipsilateral afferent renal nerve activity in WT but not TRPV1-/- mice. The sensitivity of renal sympathetic nerve activity and heart rate responses to baroreflex were reduced in TRPV1-/--CON and WT-WD and further decreased in TRPV1-/--WD compared to the WT-CON group...
October 31, 2018: Current Hypertension Reviews
Mehdi Jafari Oori, Farahnaz Mohammadi, Kian Norozi, Masoud Fallahi-Khoshnab, Abbas Ebadi
BACKGROUND: Medication adherence (MA) is the most important controlling factor of high blood pressure (HBP). There are a few MA models, but they have not been successful in predicting MA completely. Thus, this study aimed to expand a conceptual model of MA based on ecological approach. METHODS: An integrative review of the literature based on theoretical and empirical studies was completed. Data source comprised: Medline (including PubMed and Ovid), ISI, Embase, Google scholar, and internal databases such as Magiran, Google, SID, and internal magazines...
October 22, 2018: Current Hypertension Reviews
Muhammad Chaudhry, Luanda Grazette, Michael W Fong
BACKGROUND: Myxedema heart disease is an extremely rare disease entity and should be suspected in patients with unexplained heart failure refractory to conventional treatment. Myxedema coma with co- existent heart disease is not well known and very few cases have been reported. CONCLUSION: Here we present an interesting case of myxedema coma with severe valvular cardiomyopathy followed by a concise review of the literature with special emphasis on epidemiology, pathophysiology, diagnosis and therapeutic modalities...
October 1, 2018: Current Hypertension Reviews
AboTaleb Saremi, Mohammad-Ali Shafiee, Mahdi Montazeri, Negin Rashidi, Mohammad Montazeri
BACKGROUND: Preeclampsia is a global burden with 10 million incidence annually and 210 daily deaths worldwide. Diagnosis is mainly based on the features following full presentation. OBJECTIVE: This study explored whether early pregnancy circadian changes of ambulatory blood pressure monitoring (ABPM) could predict preeclampsia and hypertension. METHODS: In a prospective study, 294 pregnant women who were referred to Sarem Women's Hospital, Iran were recruited...
September 24, 2018: Current Hypertension Reviews
Gabriel T do Vale, Carla S Ceron, Natalia A Gonzaga, Janaina A Simplicio, Julio C Padovan
BACKGROUND: Beta-adrenergic receptors are expressed in cardiomyocytes and activated by either noradrenaline released from sympathetic synapses or circulating catecholamines. Their corresponding receptors have three subtypes, namely, β1, β2 and β3, which are members of the G protein-coupled receptors (GPCRs) family. Activation of β1-adrenergic receptors causes various physiological reactions including cardiac contraction and renin secretion from juxtaglomerular cells of the kidney...
September 17, 2018: Current Hypertension Reviews
Muhammad Ali Chaudhry, Allen Johnson, James Thomas Heywood
OBJECTIVES: Stiff left atrial syndrome is an intriguing clinical phenomena characterized by reduced left atrial compliance, pulmonary venous hypertension and exacerbations of volume overload. We conducted a retrospective review of patients diagnosed with stiff left atrial syndrome at our center. METHODS: All patients admitted to our hospital with volume overload and pulmonary venous hypertension who were diagnosed with stiff left atrial syndrome based on evidence by echocardiogram and right heart catheterization between July 2011 and July 2013 were included in this retrospective review...
September 16, 2018: Current Hypertension Reviews
Muhammad Ali Chaudhry, Luanda Grazette, Andrew Yoon, Adrian Correa, Michael W Fong
Acute eosinophilic myocarditis (EM) is a rare form of heart failure that is characterized by myocardial eosinophilic infiltration usually in association with peripheral eosinophilia. The underlying cause is variable and can include allergic reactions, parasitic infection, idiopathic hypereosinophilic syndrome, malignancy, Loeffler's syndrome, Churg-Strauss syndrome (CSS), early giant cell myocarditis and malignancy. The course is potentially fatal, and early diagnosis and treatment with steroids is essential...
September 3, 2018: Current Hypertension Reviews
Leandro Bueno Bergantin
BACKGROUND: Hypertension, diabetes and neurodegenerative diseases are among the most prevalent medical problems around the world, costing millions of dollars to the medical health systems. Indeed, hypertension has been associated with higher risk for decline of cognition, as evidenced in patients with Alzheimer´s disease (AD). Furthermore, there is a clear relationship between hypertension and diabetes, reflecting substantial overlap in their etiology. Calcium (Ca2+) channel blockers (CCBs) have been classically prescribed for treating hypertension because of their mechanism of action due to reducing the influx of Ca2+ into the smooth muscles cells...
August 16, 2018: Current Hypertension Reviews
Sumeet Gupta, Vikas Jhawat, Bimal Kumar Agarwal, Partha Roy, Vipin Saini
BACKGROUND: Different antihypertensive therapies (especially diuretics) are reported to induce new onset of diabetes in some hypertensive patients. α-adducin-1 (ADD1) gene is salt sensitive gene which has its role in etiology of hypertension via salt sensitivity. Therefore, the G460T polymorphism of ADD1 gene may be associated with new onset of diabetes under the influence of diuretic and other antihypertensive therapies. AIM: To assess the correlation between genetic polymorphism (ADD1 G460T polymorphism) and glycaemic disturbance under influence of diuretic and other antihypertensive drug therapies...
July 30, 2018: Current Hypertension Reviews
Vasiliki Katsi, Matthaios Didagelos, Stamatios Skevofilax, Iakovos Armenis, Athanasios Kartalis, Charalambos Vlachopoulos, Haralambos Karvounis, Dimitrios Tousoulis
Arterial hypertension is a progressive cardiovascular syndrome arising from complex and interrelated etiologies. The human microbiome refers to the community of microorganisms that live in or on the human body. They influence human physiology by interfering in several processes such as providing nutrients and vitamins and in Phase I and Phase II drug metabolism. The human gut microbiota is represented mainly by Firmicutes and Bacteroidetes and to a lesser degree by Actinobacteria and Proteobacteria, with each individual harbouring at least 160 such species...
June 12, 2018: Current Hypertension Reviews
Alberto Milan, Giulia Bruno, Ilaria Maffei, Andrea Iannaccone, Agnese Ravera, Domenica Schiavone, Franco Veglio
The introduction of carfilzomib in the treatment of relapsing and refractory multiple myeloma has allowed a significant increase in survival. The most frequent adverse effect of Carfilzomib treatment is arterial hypertension, even thought the exact physiopathological mechanism are still unclear. MM patients, on the other hand, often present significant cardiovascular risk factors and comorbidities. Uncontrolled hypertension is frequently the cause of cardiovascular complications. It has been estimated that up to 50% of subjects in the general population are unaware of their hypertensive condition and only half of those who are aware of this risk factor present good control of blood pressure...
June 10, 2018: Current Hypertension Reviews
Florence Gunawan, Hui Yi Ng, Christopher Gilfillan, Mahesan Anpalahan
BACKGROUND: Ambulatory blood pressure (ABP) monitoring in type 2 diabetes (T2DM) is not yet routine in clinical practice. OBJECTIVES: To quantify abnormal ABP patterns and their associations with diabetic complications, and to assess the reliability of office blood pressure (OBP) for assessing BP in T2DM. METHODS: In a cross-sectional study, eligible patients with T2DM underwent OBP and 24- hour ABP measurements under standardized conditions and screening for diabetic complications...
June 6, 2018: Current Hypertension Reviews
Naina Kumar, Amit Kant Singh
Hypertensive disorder of pregnancy, especially Pre-eclampsia is one of the major causes of increased maternal and perinatal morbidity and mortality all over the world. Early prediction of pre-eclampsia is the need of modern obstetrics, as this can timely prevent the progress of disease as well as related fetal and maternal morbidity and mortality. In addition to the screening of fetal aneuploidies, Rhesus-D status, fetal sex, single gene disorders, the cell-free fetal Deoxyribonucleic acid (DNA) quantification has emerged out as a promising biomarker for prediction of pre-eclampsia...
May 16, 2018: Current Hypertension Reviews
Nasser Mikhail
BACKGROUND: Liraglutide is a glucagon-like 1 (GLP-1) agonist approved for treatment of type 2 diabetes and obesity. OBJECTIVE: To review the cardiovascular effects of liraglutide including macrovascular and microvascular events, its use in heart failure, and its effects on heart rate and blood pressure. RESULTS: The impact of liraglutide on cardiovascular outcomes was examined in a large well-designed study published in 2016, the LEADER trial...
May 7, 2018: Current Hypertension Reviews
Stelina Alkagiet, Konstantinos Tziomalos
Primary aldosteronism (PA) is not only a leading cause of secondary and resistant hypertension, but is also quite frequent in unselected hypertensive patients. Moreover, PA is associated with increased cardiovascular risk, which is disproportionate to BP levels. In addition, timely diagnosis of PA and prompt initiation of treatment attenuates this increased risk. On the other hand, there are limited data regarding the usefulness of screening for PA in all asymptomatic or normokalemic hypertensive patients. More importantly, until now, no well-organized, large-scale, prospective, randomized controlled trial has proved the effectiveness of screening for PA for improving clinical outcome...
May 7, 2018: Current Hypertension Reviews
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