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Current Hypertension Reviews

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https://www.readbyqxmd.com/read/29766818/cell-free-fetal-dna-a-novel-biomarker-for-early-prediction-of-pre-eclampsia-and-other-obstetric-complications
#1
Naina Kumar, Amit Kant Singh
Hypertensive disorder of pregnancy, especially Pre-eclampsia is one of the major causes of increased maternal and perinatal morbidity and mortality all over the world. Early prediction of pre-eclampsia is the need of modern obstetrics, as this can timely prevent the progress of disease as well as related fetal and maternal morbidity and mortality. In addition to the screening of fetal aneuploidies, Rhesus-D status, fetal sex, single gene disorders, the cell-free fetal Deoxyribonucleic acid (DNA) quantification has emerged out as a promising biomarker for prediction of pre-eclampsia...
May 16, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29737256/cardiovascular-effects-of-liraglutide
#2
Nasser Mikhail
BACKGROUND: Liraglutide is a glucagon-like 1 (GLP-1) agonist approved for treatment of type 2 diabetes and obesity. OBJECTIVE: To review the cardiovascular effects of liraglutide including macrovascular and microvascular events, its use in heart failure, and its effects on heart rate and blood pressure. RESULTS: The impact of liraglutide on cardiovascular outcomes was examined in a large well-designed study published in 2016, the LEADER trial...
May 7, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29737255/should-all-hypertensive-patients-be-screened-for-primary-aldosteronism
#3
Stelina Alkagiet, Konstantinos Tziomalos
Primary aldosteronism (PA) is not only a leading cause of secondary and resistant hypertension, but is also quite frequent in unselected hypertensive patients. Moreover, PA is associated with increased cardiovascular risk, which is disproportionate to BP levels. In addition, timely diagnosis of PA and prompt initiation of treatment attenuates this increased risk. On the other hand, there are limited data regarding the usefulness of screening for PA in all asymptomatic or normokalemic hypertensive patients. More importantly, until now, no well-organized, large-scale, prospective, randomized controlled trial has proved the effectiveness of screening for PA for improving clinical outcome...
May 7, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29737254/pharmacological-treatment-of-hypertension-effects-in-endothelial-function
#4
Leonardo Cobos-Segarra, Patricio Lopez-Jaramillo, Carlos Ponte-Negretti Ci, Raul Villar, Ernesto Penaherrera
The vascular endothelium plays a crucial role to maintain the functional integrity of the cardiovascular system through the secretion of vasoactive substances such as prostacyclin and NO. Endothelial dysfunction participate in the genesis of HTA, but also hypertension produces endothelial damage. The mayor class of antihypertensive drugs have beneficial effects in the recuperation of the endothelial function, actions that are contributing to explain the impact of the adequate control of HTA in the reduction of CV events...
May 7, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29692259/quantitative-vascular-evaluation-from-laboratory-experiments-to-point-of-care-patient-experimental-approach
#5
Ricardo L Armentano, Leandro J Cymberknop
This paper illustrates the evolution of our knowledge of arterial mechanics from our initial research works up to the present time. Several techniques focused on this topic in terms of our experience are discussed. An interdisciplinary team composed by different institutions from Argentina, Uruguay, France and Spain was created to conduct research, to train human resources and to fulfill the inevitable social role of gaining access to technological innovation to improve public health.
April 22, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29683095/azilsartan-and-chlorthalidone-new-powerful-fixed-dose-antihypertensive-combination
#6
Vasiliki Katsi, Eleni Athanasiadi, Costas Tsioufis, Dimitris Tousoulis
Arterial hypertension is a disease that still affects a major part of the population worldwide, and leads to fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. From the CDC statistical analysis, as regarding to United States, 1 of every 3 adults has high blood pressure, and ╬┐nly about half (54%) of them have it under control. Furthermore, all that leads to a nation cost about $46 billion each year. Efforts to find new ways to regulate arterial hypertension are therefore imperative...
April 20, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29658440/effects-of-transcutaneous-electrical-nerve-stimulation-in-autonomic-nervous-system-of-hypertensive-patients-a-randomized-controlled-trial
#7
Sandra do Amaral Sartori, Cinara Stein, Christian Correa Coronel, Fabricio Edler Macagnan, Rodrigo Della Mea Plentz
BACKGROUND: Patients with hypertension have altered autonomic nervous system function, which are increased sympathetic activity. Transcutaneous Electrical Nerve Stimulation (TENS) is a useful modality for pain control and has also been shown to be effective in the reduction of sympathetic activity in healthy subjects and individuals with cardiovascular diseases. OBJECTIVE: The aim of this study was to verify the effects of transcutaneous electrical nerve stimulation by the evaluation of heart rate variability (HRV) in patients with essential hypertension...
April 16, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29658439/hypertension-and-aortic-stenosis-a-review
#8
Allen Rassa, Firas Zahr
BACKGROUND: Aortic stenosis is a common form of valvular heart disease which often coexists with hypertension. These diseases represent two distinct forms of left ventricular systolic overload and in combination may be associated with disadvantageous left ventricular remodeling, increased mortality and heart failure. The treatment of hypertension in aortic stenosis remains a challenging problem with limited data to guide clinical practice. METHODS: We performed a comprehensive online literature review to find relevant published literature on the topic of hypertension and aortic stenosis...
April 16, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29658438/a-systematic-review-of-first-trimester-biochemical-and-molecular-predictive-tests-for-preeclampsia
#9
Fatemeh Abdi, Zohreh Aghaie, Fatemeh Sadat Rahnemaie, Zainab Alimoradi
BACKGROUND: Preeclampsia is a multisystem disorder affecting 5%-8% of pregnant women. Considering the ongoing debate over the predicting value of some commercial first trimester tests, the aim of this study was to compare the existing first trimester screening tests for preeclampsia. METHODS: In this systematic review, relevant articles published during 2000-2017 were extracted from PubMed, Science Direct, Scopus, Cochrane Library, ISI Web of Science, and ProQuest databases...
April 16, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29651959/central-to-peripheral-arterial-stiffness-gradient-in-hemodialyzed-patients-depends-on-the-location-of-the-upper-limb-vascular-access
#10
Daniel Bia, Cintia Galli, Yanina Zocalo, Rodolfo Valtuille, Sandra Wray, Franco Pessana, Edmundo I Cabrera-Fischer
Pulse wave velocity ratio (PWV-ratio), a measure of central-to-peripheral arterial stiffness gradient, is calculated as a quotient between carotid-femoral and carotid-radial PWV (cf-PWV/cr-PWV). This new index has been reported to be significantly associated with increased mortality in hemodialyzed patients. Since several reports showed differences in arterial stiffness regarding the pathway where the vascular access (VA) is, the purpose of this research was: a) to compare arterial stiffness values obtained in the left and right sides of the body in hemodialyzed and non-hemodialyzed patients, and b) to analyze PWV-ratio values obtained in the side of the body where the VA was placed and compare them to its contralateral intact side...
April 13, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29651957/serum-uric-acid-elevation-is-associated-to-arterial-stiffness-in-hypertensive-patients-with-metabolic-disturbances
#11
Agustin J Ramirez, Alejandra Ines Christen, Ramiro A Sanchez
INTRODUCTION: Chronic serum uric acid elevation (SUA) is known to be induced by dyslipidemia, hypertension, inflammation, and insulin resistance. Therefore, it has been associated with higher risk for coronary artery disease and cardiovascular mortality. Also, increased levels of SUA have been associated with regional arterial stiffness, assessed by pulse wave velocity (PWV). AIMS: To evaluate the relationships of PWV, SUA and different metabolic parameters in essential hypertensive patients...
April 13, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29651956/quantitative-vascular-evaluation-from-laboratory-experiments-to-point-of-care-patient-clinical-approach
#12
Ricardo L Armentano, Leandro J Cymberknop
To aid in patient-specific risk stratification and diagnosis, an assessment of arterial structural and functional changes associated to a vascular disease in both early and advanced stages have been proposed in order to limit the progression or revert vascular alterations. To this end, an interdisciplinary international partnership made up by research institutions from France, Argentina, Uruguay and Spain was established, with the objective of contributing to the evaluation and follow-up of factors involved in the physiopathology of cardiometabolic diseases and human aging...
April 13, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29651955/increases-in-peripheral-systolic-pressure-levels-and-z-score-associate-gradual-aortic-pressure-increase-and-functional-arterial-impairment-in-children-and-adolescents
#13
Yanina Zocalo, Mariana Marin, Santiago Curcio, Victoria Garcia-Espinosa, Pedro Chiesa, Gustavo Giachetto, Edmundo I Cabrera-Fischer, Daniel Bia
BACKGROUND: Arterial changes associated with children and adolescents high blood pressure (HBP) states would vary depending on the arterial type, arterial indexes considered and/or on blood pressure (BP) levels. AIMS: To determine in children and adolescents: 1) if there is gradual structural-functional arterial impairment associated with gradual peripheral (brachial) systolic BP (pSBP) level or z-score increases, and 2) whether subjects with HBP levels and those with normal BP differ in the profiles of arterial changes associated with pSBP deviations...
April 13, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29651953/comparison-between-supervised-and-partly-supervised-cardiac-rehabilitation-protocols-in-hypertensive-patients-a-randomized-controlled-trial
#14
Larissa Barreto Parreira, Priscila Valverde de Oliveira Vitorino, Paulo Cesar Brandao Veiga Jardim, Ana Luiza Lima Sousa, Thiago Veiga Jardim, Watila de Moura Sousa, Alberto Fenrando Oliveira Justo, Weimar Kunz Sebba Barroso
BACKGROUND: Hypertension (HTN) is the main cause of cardiovascular diseases accounting for one third of global mortality. Physical exercise reduces the incidence and prevalence of HTN and cardiovascular morbidity and mortality. Exercises recommended for hypertensive patients include supervised cardiac rehabilitation, which occurs in rehabilitation centers, and partly supervised rehabilitation, with individual prescription of exercises conducted at patients' residences. OBJECTIVE: Compare clinical and functional parameters of hypertensive patients subjected to two cardiac rehabilitation protocols: supervised and partly supervised...
April 13, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29651958/arterial-stiffness-in-haemodialysed-patients-findings-and-controversies
#15
Edmundo I Cabrera-Fischer, Yanina Zocalo, Sandra Wray, Daniel Bia
Vascular research in end-stage renal diseases is an interesting field in which the characterization of arterial stiffness proved to be valuable to predict morbidity and mortality. Particularly, patients in renal replacement therapy have been reported to have significant increases of arterial stiffness and cardiovascular mortality. The clinical relevance of the measurement of arterial stiffness is linked to therapeutical and preventive interventions. The purpose of this work is to analyze the results of the scientific research in the field of arterial stiffness, in which hemodialyzed patients were involved, emphasizing on clinical and in-vitro research carried out by our group compared to contributions previously reported in the specialized literature...
April 12, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29651954/forward-and-backward-aortic-components-and-reflection-indexes-in-children-and-adolescents-determinants-and-role-in-high-pressure-states
#16
Yanina Zocalo, Juan M Castro, Victoria Garcia-Espinosa, Santiago Curcio, Pedro Chiesa, Gustavo Giachetto, Edmundo I Cabrera-Fischer, Daniel Bia
High blood pressure states (HBP) would differ in wave components and reflections indexes, which could associate clinical and prognostic implications. AIMS: 1) to characterize the association of aortic wave components and reflection parameters (backward [Pb], forward [Pf], Pb/Pf ratio and augmentation index [AIx]) with demographic, anthropometric, hemodynamic and arterial parameters in healthy children and adolescents; 2) to generate multivariate prediction models for the associations, to contribute to understand main determinants of Pf, Pb, Pb/Pf and AIx; 3) to identify if differences in wave reflection indexes observed in HBP could be explained by differences in the analyzed parameters...
April 12, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29618312/the-nutritional-characteristics-of-the-hypotensive-washoku-modified-dash-diet-a-sub-analysis-of-the-dash-jump-study
#17
Atsuko Kawamura, Katsuko Kajiya, Hiroko Kishi, Junko Inagaki, Makoto Mitarai, Hiroshi Oda, Seiji Umemoto, Sei Kobayashi
BACKGROUND: We developed a WASHOKU-modified DASH diet named DASH-JUMP. We previously reported the hypotensive effect of the DASH-JUMP diet in Japanese participants with untreated high-normal blood pressure (BP) or stage 1 hypertension. OBJECTIVE: We aim to introduce the DASH-JUMP diet worldwide as a new lifestyle medicine. Accordingly, we prospectively assessed the nutritional characteristics of the DASH-JUMP diet. METHODS: Participants were treated with the DASH-JUMP diet for 2 months...
April 4, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29564978/determinants-of-progression-in-early-autosomal-dominant-polycystic-kidney-disease-is-it-blood-pressure-or-renin-angiotensin-aldosterone-system-blockade
#18
Godela M Brosnahan, Kaleab Z Abebe, Charity G Moore, Kyongtae T Bae, William E Braun, Arlene B Chapman, Michael F Flessner, Peter C Harris, Marie C Hogan, Ronald D Perrone, Frederic F Rahbari-Oskoui, Theodore I Steinman, Vicente E Torres, The Halt Pkd Investigators
BACKGROUND: The HALT PKD trial in early autosomal dominant polycystic kidney disease (ADPKD) showed that intensive control of systolic blood pressure to 95-110 mmHg was associated with a 14% slower rate of kidney volume growth compared to standard control. It is unclear whether this result was due to greater blockade of the renin-angiotensin-aldosterone system (RAAS) by allowing the use of higher drug doses in the low blood pressure arm, or due to the lower blood pressure per se. METHODS: In this secondary analysis of HALT PKD Study A, we categorized participants into high and low dose groups based on the median daily equivalent dose of RAAS blocking drugs used after the initial dose titration period...
March 21, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29521243/hypertensive-versus-hiv-infected-patients-who-has-the-greatest-target-organ-damage-comparison-of-carotid-plaque-prevalence-intima-media-thickness-and-renal-resistive-index-in-the-two-groups-of-patients
#19
Lucia Taramasso, Michele Mirabella, Francesca Cappadona, Barbara Bonino, Niccolo Riccardi, Giovanni Cenderello, Giuseppe Vittorio De Socio, Claudio Viscoli, Francesca Viazzi, Antonio Di Biagio
OBJECTIVES: to compare the prevalence of target-organ damage (TOD), defined as carotid plaque, or intima media thickness, cIMT, >0.9 mm, and that of increased renal resistive index (RRI), among HIV-1-infected patients (PLWHIV) and uninfected hypertensive patients (HT-non HIV). METHODS: PLWHIV aged > 40 years and virologically suppressed were matched with pair-age, sex and BMI HT-non HIV. Patients on antihypertensive treatment were excluded. All patients' cIMT and RRI were evaluated with ultrasonography...
March 7, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29437012/marinobufagenin-in-urine-a-potential-marker-of-predisposition-to-ethanol-and-a-target-for-spironolactone
#20
Vladimir A Kashkin, Elena V Shekunova, Alexei Y Egorov, Alexei Bagrov
BACKGROUND AND OBJECTIVE: Previously it was demonstrated that digitalis-like cardiotonic steroid, marinobufagenin (MBG), is implicated in the development of ethanol addiction in rats. We hypothesized that (i) levels of sodium pump ligand, MBG, would be negatively correlated with amount of ethanol consumed by rats, and (ii) that spironolactone would oppose the MBG induced ethanol-seeking behavior and blood pressure in rats. METHODS: Voluntary consumption of 9% alcohol (vs...
February 11, 2018: Current Hypertension Reviews
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