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Personalized Medicine

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https://www.readbyqxmd.com/read/29767551/moving-beyond-the-genome-with-computer-modeling
#1
Patrik Christen
No abstract text is available yet for this article.
May 16, 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29767545/pharmacogenetics-of-novel-oral-anticoagulants-a-review-of-identified-gene-variants-future-perspectives
#2
Adna Ašić, Damir Marjanović, Jure Mirat, Dragan Primorac
Novel oral anticoagulants (NOACs) are becoming a therapy of choice in everyday clinical practice after almost 50 years during which warfarin and related coumarin derivatives were used as the main anticoagulants. Advantages of NOACs over standard anticoagulants include their predictable pharmacodynamics and pharmacokinetics, stable plasma concentrations and less drug-drug and food-drug interactions. However, pharmacogenetics has its place in administration of NOACs, as considerable interindividual variations have been detected...
May 16, 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29745790/clinical-criteria-revision-for-hereditary-lobular-breast-cancer-associated-with-e-cadherin-germline-mutations
#3
Giovanni Corso, Alessandra De Scalzi, Irene Feroce, Paolo Veronesi, Bernardo Bonanni, Viviana Galimberti
No abstract text is available yet for this article.
May 10, 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29745746/ca-15-3-predicting-breast-cancer-relapse-beware-of-vitamin-b12-deficiency
#4
Elie El Rassy, Maya Al Ghor, Joseph Kattan
A sustained increase of cancer antigen 15-3 serum levels was found in a 54-year-old woman treated 2 years ago for early stage breast cancer, without any evidence of cancer recurrence. The patient thereafter developed severe megaloblastic anemia secondary to vitamin B12 deficiency. Supplementation with B12 to reverse the anemia led to the normalization of the cancer antigen 15-3 serum levels. As such, with the limited understanding of molecular biology, the integrative approach of clinical history, physical examination, and diagnostic imaging remain pivotal in the management of cancer patients...
May 10, 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29693487/the-potential-impact-of-monitoring-disease-activity-biomarkers-on-rheumatoid-arthritis-outcomes-and-costs
#5
Gary M Oderda, Grant D Lawless, Grace C Wright, Samuel R Nussbaum, Renwyck Elder, Kibum Kim, Diana I Brixner
Rheumatoid arthritis (RA) management requires monitoring of disease activity to determine course of treatment. Global assessments are used in clinical practice to determine RA disease activity. Monitoring disease activity via biomarkers may also help providers optimize biologic and nonbiologic drug use while decreasing overall drug spend by delaying use of expensive biologic therapies. By testing multiple biologic domains at the same time, a multibiomarker disease activity test may have utility in RA patient management, through improved intra- and inter-rater reliability...
April 25, 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29714131/functional-consequences-of-genetic-variation-in-sodium-channel-modifiers-in-early-onset-lone-atrial-fibrillation
#6
Federico Denti, Christian Paludan-Müller, Søren-Peter Olesen, Stig Haunsø, Jesper Hastrup Svendsen, Morten Salling Olesen, Bo Hjorth Bentzen, Nicole Schmitt
AIM: We investigated the effect of variants in genes encoding sodium channel modifiers SNTA1 and GPD1L found in early onset atrial fibrillation (AF) patients. PATIENTS & METHODS: Genetic screening in patients with early onset lone AF revealed three variants in GPD1L and SNTA1 in three AF patients. Functional analysis was performed by patch-clamp electrophysiology. RESULTS: Co-expression of GPD1L or its p.A326E variant with NaV 1.5 did not alter INa density or current kinetics...
March 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29714130/erratum
#7
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29714129/personalized-medicine-in-inflammatory-cardiomyopathy
#8
Balram Neupane, Qifeng Zhou, Meinrad Gawaz, Michael Gramlich
Inflammatory cardiomyopathy is the result of persistent myocardial inflammation which can arise from both infectious or noninfectious causes. While most patients with acute myocarditis recover, up to 20% develop inflammatory cardiomyopathy with chronic heart failure. The interaction between host factors and factors of the agent that triggered myocardial inflammation must be considered to fully understand the individual mechanism of disease. Several inflammatory biomarkers, histology, immunohistochemistry, advanced imaging technologies as well as molecular high-throughput sequencing techniques help to identify disease pathways and to establish a comprehensive, individualized treatment approach, which can include anti-inflammatory medication, antiviral drugs and heart failure therapy...
March 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29714128/association-of-genetic-polymorphisms-in-immune-related-lncrna-with-osteoarthritis-susceptibility-in-chinese-han-population
#9
Qiang Wang, Yinliang Wu, Fanian Li, Heping Zhu, Bo Zhou, Yuqiang Qian, Chi Ge, Jing Xu, Liang Chen, Miao Chu, Long Jiang, Jun Peng
AIM: Immune-related lncRNA may influence osteoarthritis (OA) susceptibility. We conducted this study to assess whether the genetic variants in several immune-related lncRNA influence OA susceptibility. METHODS: The current research genotyped four SNPs in 306 OA patients and 316 healthy controls, including PRNCR1 rs7463708, PRNCR1 rs1456315, PRNCR1 rs16901946 and KIF13B1 rs643472, to investigate their associations with OA susceptibility. RESULTS: We identified that PRNCR1 rs1456315 was associated with OA susceptibility in Chinese Han population (recessive model: odds ratio = 2...
March 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29714127/novel-akt1-mutations-associated-with-cell-cycle-abnormalities-in-gastric-carcinoma
#10
Souvik Ghatak, Sylvine Lalnunhlimi, Freda Lalrohlui, Jeremy L Pautu, John Zohmingthanga, Ajaikumar B Kunnumakkara, Nachimuthu Senthil Kumar
AIM: The aim of this study is to identify the AKT1 gene mutation driven pathogenicity in gastric cancer for Mizo population. METHODS: 50 diffuse-type gastric tumors were analyzed for AKT1 exon 2 and 14 mutations. Cell-cycle aberration was analyzed in the AKT1-mutated samples and the stability of the protein as well as exonic splicing enhancer motifs were examined. RESULTS: The novel mutations, 15553T >A and 25376C >G might affect the exonic splicing enhancers and silencers...
March 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29714126/corrigendum
#11
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29714125/multivariate-analysis-for-coronary-heart-disease-in-heterozygote-familial-hypercholesterolemia-patients
#12
Juan Francisco Sánchez Muñoz-Torrero, Maria D Rivas, Jose Zamorano, Pedro Pablo Joya-Vázquez, Leopoldo Perez de Isla, Teresa Padro, Pedro Mata, The Safeheart Investigators
AIM: rs599839 polymorphism has been related with low levels of cholesterol and reduced coronary heart disease (CHD). METHODS: We investigated the frequency of this polymorphism in patients with heterozygous familial hypercholesterolemia (HeFH) in the Spanish familial hypercholesterolemia cohort, 230 with and 202 without CHD. Results & discussion: A lower G-allele prevalence was observed in HeFH patients with CHD with respect to controls, 35 versus 45%, respectively (p = 0...
March 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29714124/clinical-application-of-pharmacogenetics-in-pain-management
#13
D Max Smith, Kristin W Weitzel, Larisa H Cavallari, Amanda R Elsey, Siegfried Of Schmidt
There is growing experience translating genomic data into clinical practice, as seen with the Implementing GeNomics In pracTicE (IGNITE) network. A primary example is the influence of CYP2D6 genotype on the beneficial and adverse effects of some opioids. Clinical recommendations exist to guide drug therapy based on CYP2D6 genotype for codeine, tramadol, oxycodone and hydrocodone, although the level of supporting evidence differs by drug. Limited evidence also supports the use of genetic data to guide other medications in chronic pain therapy, including tricyclic antidepressants and celecoxib...
March 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29714123/how-genome-editing-could-be-used-in-the-treatment-of-cardiovascular-diseases
#14
Kiran Musunuru
No abstract text is available yet for this article.
March 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29714122/alk-rearranged-adenocarcinoma-transformed-to-small-cell-lung-cancer-a-new-entity-with-specific-prognosis-and-treatment
#15
Charbel Hobeika, Gaëlle Rached, Roland Eid, Fady Haddad, Salim Chucri, Hampig R Kourie, Joseph Kattan
Driving molecular mutations such as rearrangement of ALK and EGFR mutation is present in 5-10% of non-small-cell lung cancer. Tyrosine kinase inhibitors have shown good efficacy and thus become the standard of care. However, tumors have developed several resistance mechanisms against tyrosine kinase inhibitors, including transformation to small-cell lung carcinoma (SCLC). Transformation to SCLC after administration of anti-EGFR in EGFR-mutated adenocarcinoma has been well documented. Similarly, it appears that the same transformation happens in ALK-rearranged adenocarcinoma after the use of anti-ALK...
March 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29714121/how-advances-in-personalized-medicine-will-change-rheumatology
#16
Carlo Selmi, Elizaveta Kon, Maria De Santis, Ennio G Favalli, Rolando Cimaz, Elena Generali, Luigi Sinigaglia
No abstract text is available yet for this article.
March 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29714120/pharmacogenomic-guided-dosing-for-warfarin-too-little-too-late
#17
Alan Hb Wu
No abstract text is available yet for this article.
March 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29714119/erratum
#18
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29739269/analytical-validation-of-a-psychiatric-pharmacogenomic-test
#19
Michael R Jablonski, Nina King, Yongbao Wang, Joel G Winner, Lucas R Watterson, Sandra Gunselman, Bryan M Dechairo
AIM: The aim of this study was to validate the analytical performance of a combinatorial pharmacogenomics test designed to aid in the appropriate medication selection for neuropsychiatric conditions. MATERIALS & METHODS: Genomic DNA was isolated from buccal swabs. Twelve genes (65 variants/alleles) associated with psychotropic medication metabolism, side effects, and mechanisms of actions were evaluated by bead array, MALDI-TOF mass spectrometry, and/or capillary electrophoresis methods (GeneSight Psychotropic, Assurex Health, Inc...
February 7, 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29714118/prediction-of-response-to-targeted-and-immune-checkpoint-therapies
#20
Edward D Blair, Martina Kaufmann, Mieke Keppens
Targeted therapies continue to be key components of cancer treatment. New approaches to detection of acquired resistance at the genomic level, in combination with new therapies, help to overcome the challenges that are seen frequently, rapidly and broadly across tumor pathologies, and provide opportunities for cancer management. In the last several years, a new breed of modalities called immune checkpoint inhibitors have come to the forefront of clinically effective treatments. A plethora of rapid approvals and early access initiatives have seen anti-cytotoxic T-lymphocyte-associated antigen-4, and particularly anti-programmed death receptor-1 therapies, deployed in a number of tumor indications of high unmet need...
January 2018: Personalized Medicine
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