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Personalized Medicine

Michael A Kiebish, Niven R Narain
No abstract text is available yet for this article.
November 13, 2018: Personalized Medicine
Lukas Perkhofer, Pierre-Olivier Frappart, Martin Müller, Alexander Kleger
The establishment of organoid culture systems represents a milestone on the route toward successful personalized medicine. This mini review provides an update on the current status of organoid technology and summarizes their applications in personalized medicine. Organoids can be defined as 3D structures derived either from pluripotent or organ restricted stem cells harboring the ability to mimic in vivo architecture and multi lineage differentiation of terminally differentiated tissues. Due to their unique ability of virtually unlimited self-renewal, organoid cultures should be distinguished from previous 'sphere'-culture assays, for example, 'tumor spheres' that have already been described and applied over the last decades...
November 12, 2018: Personalized Medicine
Qaisar Ali, Arshad Jamal, Muhammad Imran, Sajjad Ullah, Irfan Kalam, Shafi Ullah, Ahmed B Waqar
AIM: There is a strong correlation of IL28B rs12979860 genetic variations and gender with spontaneous clearance of hepatitis C virus (HCV) infection. MATERIALS & METHODS: HCV-infected subjects were categorized into HCV spontaneous clearance (SC) group and chronic hepatitis C (CHC) group on the basis of anti-HCV antibodies and HCV RNA level and follow-up of 6 months. 35 subjects were classified in SC group and 165 subjects were classified in CHC group. IL28B rs12979860 genotypes were determined by allele-specific PCR...
November 6, 2018: Personalized Medicine
Nicoletta Urbano, Manuel Scimeca, Elena Bonanno, Orazio Schillaci
No abstract text is available yet for this article.
November 6, 2018: Personalized Medicine
Birendra K Yadav, Chhagan Bihari
AIM: India has a high hepatobiliary disease burden, yet very little research has been done in this field. A major roadblock in the translational research is the unavailability of quality biosamples with standardized clinical annotations. Having a national level biobank facility can circumvent the problem. The Institute of Liver and Biliary Sciences being a premier liver institute, undertook the initiative to establish the national liver disease biobank. METHODOLOGY: We conducted a survey among the potential users of biobank resources...
November 5, 2018: Personalized Medicine
Lewis J Frey
With the rapid growth of health-related data including genomic, proteomic, imaging and clinical, the arduous task of data integration can be overwhelmed by the complexity of the environment including data size and diversity. This report examines the role of data integration strategies for big data predictive analytics in precision medicine research. Infrastructure-as-code methodologies will be discussed as a means of integrating and managing data. This includes a discussion on how and when these strategies can be used to lower barriers and address issues of consistency and interoperability within medical research environments...
November 2, 2018: Personalized Medicine
Ioannis D Kyrochristos, Demosthenes E Ziogas, Dimitrios H Roukos
No abstract text is available yet for this article.
November 2, 2018: Personalized Medicine
Qaisar Ali, Irfan Kalam, Sajjad Ullah, Arshad Jamal, Muhammad Imran, Shafi Ullah, Khurshid Iqbal, Ahmed B Waqar
AIM: The correlation of IL28-B genetic variants (rs12979860) with combinational therapy (peg-interferon, sofosbuvir plus ribavirin) of hepatitis C virus infection were studied in 154 chronic hepatitis C patients. METHODS & RESULTS: The sustained virological response for efficient antiviral regimen was achieved in 75.32% treated individuals. Three genotypes of rs12979860 (CC, CT and TT) were compared both in sustained virological response and nonresponders groups (p = 0...
November 1, 2018: Personalized Medicine
Abdolrasoul Talei, Sedigheh Tahmasebi, Majid Akrami, Vahid Zangouri, Abbas Rezaianzadeh, Peyman Arasteh, Tannaz Eghbali, Sara Hosseini
AIM: This is a description of the largest breast cancer (BC) registry in Iran, termed the Shiraz Breast Cancer Registry (SBCR). METHODS: Data on baseline and clinical characteristics, socioeconomic status, imaging, physical examination, histopathology, treatment and prognosis have been recorded for each individual. RESULTS: Overall, 5937 were included in the report. Mean age of first presentation was 49.05 ± 11.69 years. Mean tumor size was 2...
October 30, 2018: Personalized Medicine
Fatemeh Yazarlou, Vahid Kholghi-Oskooei, Mandana Afsharpad, Leila Nekoohesh, Tamouchin Moharrami, Hanie M Rad, Soudeh Ghafouri-Fard, Mohammad H Modarressi
AIM: Cancer-testis antigens (CTAs) have specific expression in gametogenic tissues and aberrant expression in cancers. Materials & methods: We assessed expression of five testis-specific genes namely KIF2B, CST8, TMEM225, RBM46, OAZ3 in bladder cancer tissues, adjacent non-neoplastic tissues and urinary cell pellets (UCPs) of bladder cancer patients compared with nonmalignant conditions. RESULTS: Expressions of all CTAs were higher in UCPs of bladder cancer patients compared with nonmalignant conditions...
October 26, 2018: Personalized Medicine
Xi Zhao, Hui-Wen Zhang, Rui-Xia Xu, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Jian-Jun Li
AIM: The link of oxidized-low-density lipoprotein (ox-LDL) with premature coronary artery disease (CAD) has previously been less examined. Materials & methods: A total of 1217 patients with angiography-proven CAD were consecutively enrolled and divided into very-early CAD (VECAD), early CAD and late CAD subgroups. And 72 normal control of VECAD were examined. All the subjects were followed-up for an average of 31 months. RESULTS: Patients with VECAD had higher ox-LDL levels; and logistic regression analysis indicated that ox-LDL was an independent risk factor for VECAD among patients with CAD (adjusted odds ratio: 1...
October 26, 2018: Personalized Medicine
Julia di Iulio
No abstract text is available yet for this article.
October 22, 2018: Personalized Medicine
Christophe Le Tourneau, Maud Kamal, Ivan Bièche
No abstract text is available yet for this article.
September 27, 2018: Personalized Medicine
Anya Er Prince, Benjamin E Berkman
As new, high-powered sequencing technologies are increasingly incorporated into genomics research, we believe that there has been a break point in how risks and benefits associated with genetic information are being characterized and understood. Genomic sequencing provides the potential benefit of a wealth of information, but also has the potential to alter how we conceptualize risks of sequencing. Until now, our conceptions of risks and benefits have been generally static, arising out of the early ethical, legal and social implications studies conducted in the context of targeted genetics...
September 27, 2018: Personalized Medicine
Peter J Polverini
No abstract text is available yet for this article.
September 27, 2018: Personalized Medicine
Karen M Meagher, Jonathan S Berg
No abstract text is available yet for this article.
September 27, 2018: Personalized Medicine
Dianhuai Meng, Wei He, Peng Huang, Dinghua Liu, Lingling Zhong, Rongbin Yu, Jianan Li
AIM: Polymorphisms of DNA repair enzyme gene may alter the ability to repair damage and in turn may contribute to ischemic stroke susceptibility and outcome. METHODS: We selected 316 ischemic stroke patients and 302 healthy controls. Then we genotyped SNPs of PARP-1 rs3219119, rs2271347 and APE1 rs1130409 in patient and control groups. RESULTS: Polymorphism in PARP-1 rs2271347 was significantly associated with increased ischemic stroke risk (additive model: OR: 1...
September 27, 2018: Personalized Medicine
Jessilyn Dunn, Ryan Runge, Michael Snyder
Wearable sensors are already impacting healthcare and medicine by enabling health monitoring outside of the clinic and prediction of health events. This paper reviews current and prospective wearable technologies and their progress toward clinical application. We describe technologies underlying common, commercially available wearable sensors and early-stage devices and outline research, when available, to support the use of these devices in healthcare. We cover applications in the following health areas: metabolic, cardiovascular and gastrointestinal monitoring; sleep, neurology, movement disorders and mental health; maternal, pre- and neo-natal care; and pulmonary health and environmental exposures...
September 27, 2018: Personalized Medicine
Yilong Hou, Lang Bai, Nan Jiang, Zilong Yao, Li Xue, Bin Yu
AIM: This study aims to investigate the link between TNF-α gene SNPs and patients with extremity chronic osteomyelitis in China. METHODOLOGY: Our study included 433 subjects, composed of 233 extremity chronic osteomyelitis patients and 200 controls. Six single-nucleotide polymorphisms (rs1799964, rs1800630, rs1799724, rs1800750, rs1800629 and rs361525) in TNF-α gene were detected by the SNaPshot genotyping method. RESULTS: Significant genotype distribution of rs1799964 was identified between patients and healthy controls (p = 0...
September 27, 2018: Personalized Medicine
Benjamas Chuaychoo, Rungsunn Tungtrongchitr, Wantanee Kriengsinyos, Siriporn Tuntipopipat, Nattira On-Nom, Chaowanee Chupeerach
AIM: The risk of vitamin D binding protein (DBP) variations in chronic obstructive pulmonary disease (COPD) compared with non-COPD Thai males were investigated. MATERIALS & METHODS: The rs7041 and rs4588 polymorphisms of the DBP gene and protein level were measured in 136 COPD and 68 non-COPD Thai males. RESULTS: In the COPD group, GC1-1 gave increased forced expiratory volume at 1 s % predicted compared with GC1-2 but with no significant difference...
September 27, 2018: Personalized Medicine
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