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Blood Transfusion, Trasfusione del Sangue

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https://www.readbyqxmd.com/read/29757137/reversal-of-apixaban-induced-alterations-in-haemostasis-by-different-coagulation-factor-concentrates-in-patients-after-hip-or-knee-replacement-surgery
#1
Katrin Schmidt, Kerstin Krüger, Elisabeth Langer, Martin Schmutzler, Elke Johnen, Klaus D Wernecke, Christian Von Heymann, Mareike K Körber
BACKGROUND: Apixaban is a direct oral anticoagulant (DOAC) with a specific inhibition of activated factor X (FXa). In case of bleeding or need of urgent surgery a direct antidote is not yet available. Off-label application of non-specific haemostatic agents, such as prothrombin complex concentrate (PCC) and recombinant FVIIa (rFVIIa), has been reported to reverse the effects of apixaban in in vitro and animal studies. The aim of this study is to measure the reversal potential of PCC and rFVIIa in patients with prophylactic apixaban concentrations...
May 11, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29757133/haemolysis-index-for-the-screening-of-intravascular-haemolysis-a-novel-diagnostic-opportunity
#2
REVIEW
Giuseppe Lippi, Emmanuel J Favaloro, Massimo Franchini
The diagnostic approach to patients with intravascular haemolysis remains challenging, since no first-line laboratory test seems to be entirely suitable for the screening of this condition. Recent evidence shows that an enhanced cell-free haemoglobin (fHb) concentration in serum or plasma is a reliable marker of red blood cell injury, and may also predict clinical outcomes in patients with different forms of haemolytic anaemias. However, the routine use of the haemiglobincyanide assay, the current reference method for measuring fHb, seems unsuitable for a timely diagnosis of intravascular haemolysis, for many safety and practical reasons...
May 8, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29757135/a-nationwide-retrospective-study-on-prevalence-of-hepatitis-e-virus-infection-in-italian-blood-donors
#3
Enea Spada, Simonetta Pupella, Giulio Pisani, Roberto Bruni, Paola Chionne, Elisabetta Madonna, Umbertina Villano, Matteo Simeoni, Sara Fabi, Giuseppe Marano, Cinzia Marcantonio, Patrizio Pezzotti, Anna R Ciccaglione, Giancarlo M Liumbruno
BACKGROUND: In Europe, hepatitis E virus (HEV) infection is mainly a food-borne zoonosis, but it can also be transmitted by blood transfusion. It is usually a mild and self-limited infection. However, immunocompromised persons, who are also those more likely to undergo blood transfusions, may develop chronic hepatitis and often cirrhosis. Since this is a potential threat to blood safety, we aimed to investigate HEV prevalence in Italian blood donors. MATERIALS AND METHODS: We used plasma donations collected during 2015-2016 by blood services (BS) scattered throughout the Italian regions and intended for the production of plasma-derived medicines...
May 4, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29757139/a-proposal-for-a-rational-transfusion-strategy-in-patients-of-european-and-north-african-descent-with-weak-d-type-4-0-and-4-1-phenotypes
#4
EDITORIAL
Willy A Flegel, Thierry Peyrard, Jacques Chiaroni, Christophe Tournamille, Déborah Jamet, France Pirenne
No abstract text is available yet for this article.
May 3, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29757130/tranexamic-acid-to-prevent-post-partum-haemorrhage
#5
EDITORIAL
Riana Van Der Linde, Emmanuel J Favaloro
No abstract text is available yet for this article.
May 3, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29792592/43%C3%A2-convegno-nazionale-di-studi-di-medicina-trasfusionale-genova-23-25-maggio-2018
#6
Pierluigi Berti, Francesco Bennardello, Serelina Coluzzi, Patrizia Di Gregorio, Giuseppina Facco, Francesco Fiorin, Claudio Velati, Domenico Visceglie
No abstract text is available yet for this article.
May 23, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29517967/the-use-of-viscoelastic-haemostatic-assays-in-non-cardiac-surgical-settings-a-systematic-review-and-meta-analysis
#7
REVIEW
Massimo Franchini, Carlo Mengoli, Mario Cruciani, Marco Marietta, Giuseppe Marano, Stefania Vaglio, Simonetta Pupella, Eva Veropalumbo, Francesca Masiello, Giancarlo M Liumbruno
BACKGROUND: Thrombelastography (TEG) and rotational thromboelastometry (ROTEM) are viscoelastic haemostatic assays (VHA) which exploit the elastic properties of clotting blood. The aim of this systematic review and meta-analysis was to evaluate the usefulness of these tests in bleeding patients outside the cardiac surgical setting. MATERIALS AND METHODS: We searched the Cochrane Library, MEDLINE, EMBASE and SCOPUS. We also searched clinical trial registries for ongoing and unpublished studies, and checked reference lists to identify additional studies...
May 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29517964/the-use-of-viscoelastic-haemostatic-assays-in-non-cardiac-surgical-settings-a-systematic-review-and-meta-analysis
#8
EDITORIAL
Raimondo De Cristofaro
No abstract text is available yet for this article.
May 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28686150/use-of-fresh-frozen-plasma-in-2012-at-the-fondazione-ca-granda-hospital-of-milan-assessment-of-appropriateness-using-record-linkage-techniques-applied-to-data-routinely-recorded-in-various-hospital-information-systems
#9
Monica Lanzoni, Barbara Olivero, Andrea Artoni, Maurizio Marconi, Elisabetta Raspollini, Silvana Castaldi
BACKGROUND: The Quality Unit of a research and teaching hospital in Milan assessed the increased clinical use of fresh-frozen plasma in patients treated during 2012 in order to evaluate the appropriateness of this use. MATERIALS AND METHODS: For each patient in the study, a pathology profile was generated by means of record linkage techniques involving data collected through different information systems. Patients' information was combined using the patient identifier key generating pathology profiles exported to an Excel file...
May 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28488971/quality-assessment-and-transfusion-efficacy-of-buffy-coat-derived-platelet-concentrates-washed-with-platelet-additive-solution
#10
Hermógenes Fernández-Muñoz, Cristina Castilla-Llorente, Eva M Plaza, Cristina Martínez-Millán, Inmaculada Heras, Pastora Iniesta, María L Amigo, Francisca Ferrer-Marin, María J Candela, María L Lozano, Vicente Vicente, José Rivera
BACKGROUND: Transfusion of washed platelet concentrates (W-PC) is recommended for some patients, such as those who have had previous severe allergic transfusion reactions. However, we still lack a standardised method for preparing these products. Here, we assessed the effect of a manual washing procedure on in vitro platelet quality and on the transfusion efficacy of W-PCs. MATERIALS AND METHODS: Buffy coat-derived W-PC in Composol solution were prepared by one-step centrifugation...
May 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28488970/is-it-time-to-re-think-a-sustainable-banking-model-for-the-italian-cord-blood-network
#11
EDITORIAL
Nicoletta Sacchi
No abstract text is available yet for this article.
May 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28488969/a-cost-analysis-of-public-cord-blood-banks-belonging-to-the-italian-cord-blood-network
#12
Simonetta Pupella, Maria Bianchi, Anna Ceccarelli, Deanna Calteri, Letizia Lombardini, Andrea Giornetti, Giuseppe Marano, Massimo Franchini, Giuliano Grazzini, Giancarlo M Liumbruno
BACKGROUND: Public cord blood banking is currently managed in Italy by a network of 19 regional cord blood banks coordinated by the National Blood Centre and the National Transplant Centre. A cost analysis was carried out within the Italian network to determine the relationship between cost of cord blood collection and banking and size of the bank inventory, which ranged from 106 to 9,341 units on December 31st , 2012. MATERIALS AND METHODS: The 19 banks were invited to report costs incurred in 2012 related to cord blood unit collection, transportation, biological validation, characterisation, manipulation, cryopreservation, storage, data management, and general costs...
May 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28488965/mild-to-moderate-foeto-maternal-haemorrhage-in-the-third-trimester-and-at-term-of-pregnancy-quantitative-determination-and-clinical-diagnostic-evaluation
#13
Fausta Beneventi, Chiara Cavagnoli, Elena Locatelli, Silvia Bariselli, Margherita Simonetta, Gianluca Viarengo, Cesare Perotti, Arsenio Spinillo
BACKGROUND: Foeto-maternal haemorrhage (FMH), a gestational event that occurs before or during delivery, consists of a loss of foetal blood into the maternal circulation. FMH occurs more frequently during the third trimester or labour both in normal and complicated pregnancies. In the case of alloimmunisation, the maternal immunological response and the severity of the resulting foetal or neonatal disease depend on the amount of foetal blood that passes into the maternal circulation. The aim of this study was to determine FMH in the third trimester and at term of pregnancy and to evaluate the role of clinical and ultrasound markers in the prediction of FMH...
May 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28488961/effect-of-storage-period-of-red-blood-cell-suspensions-on-helper-t-cell-subpopulations
#14
Salih H Bal, Yasemin Heper, Levent T Kumaş, Furkan Guvenc, Ferah Budak, Güher Göral, Haluk B Oral
BACKGROUND: The aim of this study was to investigate the immunological alterations that occur during the storage of erythrocyte suspensions which may lead to transfusion-related immunomodulation following allogeneic blood transfusion. MATERIALS AND METHODS: One part of the erythrocyte suspensions obtained from donors was leucoreduced while the other part was not. The leucoreduced (LR) and non-leucoreduced (NL) erythrocyte suspensions were then further divided into three equal amounts which were stored for 0, 21 or 42 days prior to measurements, by enzyme-linked immunosorbent assays, of cytokine levels in their supernatants...
May 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28488958/strategies-to-identify-candidates-for-d-variant-genotyping
#15
Xunda Luo, Margaret A Keller, Ian James, Michelle Grant, Shiguang Liu, Kellie Simmons Massey, Andrew Czulewicz, Sandra Nance, Yanhua Li
BACKGROUND: RhD variants have altered D epitopes and/or decreased antigen copies per red cell. Individuals carrying these variants may test antigen negative, weakly positive, or positive by serology, and may or may not be at risk of alloimmunisation after exposure. There have been recommendations to perform RHD genotyping of patients, pregnant women and females of childbearing potential with serological weak D phenotype, to guide prophylactic use of Rh immune globulin (RhIG), and better conserve D-negative blood products...
May 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28488956/introduction-of-thromboelastometry-guided-administration-of-fresh-frozen-plasma-is-associated-with-decreased-allogeneic-blood-transfusions-and-post-operative-blood-loss-in-cardiopulmonary-bypass-surgery
#16
Junko Ichikawa, Takahito Marubuchi, Keiko Nishiyama, Mitsuharu Kodaka, Klaus Görlinger, Makoto Ozaki, Makiko Komori
BACKGROUND: Cardiac surgery is frequently associated with excessive blood loss requiring multiple blood transfusions which are, in turn, associated with increased morbidity and mortality. We evaluated the effectiveness of rotational thromboelastometry (ROTEM® )-guided administration of fresh-frozen plasma (FFP) with regards to blood loss, transfusion requirements, and major post-operative complications. MATERIALS AND METHODS: Coagulation management in 68 prospective patients undergoing cardiac surgery with cardiopulmonary bypass was based on a treatment algorithm guided by ROTEM® measurements...
May 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28488955/reporting-transfusion-related-acute-lung-injury-by-clinical-and-preclinical-disciplines
#17
Anna L Peters, Emma K Van De Weerdt, Eline J Goudswaard, Jan M Binnekade, Jaap J Zwaginga, Erik A M Beckers, Sacha S Zeerleder, Marian G J Van Kraaij, Nicole P Juffermans, Alexander P J Vlaar
BACKGROUND: Disciplines involved in diagnosing transfusion-related acute lung injury (TRALI) report according to a "one-hit" theory. However, studies showed that patients with an underlying condition are at increased risk of the development of TRALI. We investigated whether accumulating evidence on the "two-hit" theory has changed the practice of reporting TRALI. MATERIALS AND METHODS: Departments of haematology, haemovigilance, transfusion medicine, intensive care and anaesthesiology from all Dutch hospitals with at least five beds equipped for mechanical ventilation were invited to participate in an online survey...
May 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287381/a-preliminary-evaluation-of-next-generation-sequencing-as-a-screening-tool-for-targeted-genotyping-of-erythrocyte-and-platelet-antigens-in-blood-donors
#18
Agnieszka Orzińska, Katarzyna Guz, Michał Mikula, Maria Kulecka, Anna Kluska, Aneta Balabas, Monika Pelc-Kłopotowska, Jerzy Ostrowski, Ewa Brojer
BACKGROUND: Matching the compatibility of donor blood with the recipient's antigens prevents alloimmunisation. Next-generation sequencing (NGS) technology is a promising method for extensive blood group and platelet antigen genotyping of blood donors. It circumvents the limitations of detecting known alleles based on predefined polymorphisms and enables targeted sequencing on a massive scale. The aim of this study was to evaluate the NGS AmpliSeq application on the Ion Torrent platform as a screening tool for genotyping blood donors' erythrocyte/platelet antigens...
May 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287376/increase-of-plasma-concentration-to-10-improves-a-number-of-in-vitro-storage-parameters-of-apheresis-platelets-suspended-in-a-bicarbonate-containing-additive-solution-and-stored-with-a-24-hour-interruption-of-agitation
#19
Stephen J Wagner, Andrey Skripchenko, Cheryl A Hapip, Nadine Kaelber, Annette Turgeon
BACKGROUND: A previous study demonstrated several pH failures during 7-day storage of platelets suspended in 5% plasma/95% PAS-5 following a 24-hour interruption of agitation. The aim of this study was to investigate whether pH control improves in platelets stored in PAS-5 with 10% plasma following interruption of agitation. MATERIALS AND METHODS: Four aliquots were prepared from a single unit of apheresis platelets: two each with 5% and 10% plasma. After resting for 1 hour, the aliquots were placed on an agitator...
May 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28151387/bidirectional-inefficacy-or-intolerability-of-thrombopoietin-receptor-agonists-new-data-and-a-concise-review
#20
Fabian Depré, Nasra Aboud, Beate Mayer, Abdulgabar Salama
BACKGROUND: There is evidence that the thrombopoietin-receptor agonists romiplostim and eltrombopag may have different therapeutic values and adverse reaction profiles. Here we present new data and provide a review of all studies dealing with switching between these two drugs. MATERIALS AND METHODS: A total of 89 patients (38 males and 51 females, aged between 14-87 years) were treated with eltrombopag and/or romiplostim between 2007 and 2016 at our institution...
May 2018: Blood Transfusion, Trasfusione del Sangue
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