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Blood Transfusion, Trasfusione del Sangue

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https://www.readbyqxmd.com/read/30201085/influence-of-apheresis-collection-device-and-container-on-the-storage-properties-of-platelets-in-90-pas-5-10-plasma
#1
Stephen J Wagner, Cheryl A Hapip, Annette Turgeon, Lenora Abel, Nadine Kaelber
BACKGROUND: The storage properties of apheresis platelets suspended in the experimental additive solution PAS-5 and 10% plasma may be affected by the collection instrument or storage container. METHODS AND EXPERIMENTAL DESIGN: The same consenting 12 donors provided A or T platelets with concurrent plasma on four occasions in 100% plasma. Following collection and resting, the platelets were centrifuged, and plasma was expressed and resuspended in PAS-5 to yield units with 10% plasma...
September 5, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/30201086/molecular-genetic-analysis-of-weak-abo-subgroups-in-the-chinese-population-reveals-ten-novel-abo-subgroup-alleles
#2
Haobo Huang, Sha Jin, Xi Liu, Zhongying Wang, Qiong Lu, Liangfeng Fan, Wei Shen, Hang Lei, Chengrui Qian, Xuefeng Wang, Dong Xiang, Xiaohong Cai
BACKGROUND: A weak ABO subgroup is one of the most important causes of an ABO blood grouping discrepancy. Here, we investigated the distribution of weak ABO subgroups in the Chinese population and identified ten novel weak ABO subgroup alleles. MATERIAL AND METHODS: We performed phenotype investigations by serological studies, analysed the DNA sequence of the ABO gene by direct sequencing or sequencing after cloning, and evaluated the role of glycosyltransferase mutations by in silico analysis and in vitro expression assay...
September 3, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/30201084/factors-affecting-the-quality-safety-and-marketing-approval-of-clotting-factor-concentrates-for-haemophilia
#3
REVIEW
Albert Farrugia, Giancarlo M Liumbruno, Fabio Candura, Samantha Profili, Josephine Cassar
Selecting therapeutic products for the treatment of haemophilia follows the process of obtaining market approval of products submitted to the scrutiny of a regulatory agency. In well-resourced countries, key decisions on whether a product is sufficiently safe and of high quality are made by highly expert and well-resourced agencies, such as the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA). In countries lacking such agencies, well-informed decisions can still be made through an appreciation of the key issues affecting the quality, safety and efficacy of haemophilia products...
September 3, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/30201083/efficacy-of-topical-tranexamic-acid-within-a-blood-saving-programme-for-primary-total-hip-arthroplasty-a-pragmatic-open-label-randomised-study
#4
Nuria Pérez-Jimeno, Manuel Muñoz, Jesús Mateo, Ana P Mayoral, Antonio Herrera
BACKGROUND: Total hip arthroplasty entails considerable peri-operative blood loss, which may lead to acute post-operative anaemia and red blood cell transfusion. This study was aimed at assessing whether the addition of topical tranexamic acid to our ongoing blood-saving protocol for total hip arthroplasty was effective and safe. MATERIALS AND METHODS: A pragmatic, prospective, open-label randomised study of patients scheduled for total hip arthroplasty at a single centre was conducted...
September 3, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/30201082/efficacy-of-platelet-rich-plasma-as-conservative-treatment-in-orthopaedics-a-systematic-review-and-meta-analysis
#5
REVIEW
Massimo Franchini, Mario Cruciani, Carlo Mengoli, Giuseppe Marano, Simonetta Pupella, Eva Veropalumbo, Francesca Masiello, Ilaria Pati, Stefania Vaglio, Giancarlo M Liumbruno
BACKGROUND: The aim of this systematic review and meta-analysis was to evaluate the benefit of platelet-rich plasma (PRP) in non-surgical orthopaedic procedures. MATERIAL AND METHODS: We searched the Cochrane Wounds Specialized Register, CENTRAL, MEDLINE (through PUBMED), Embase, and SCOPUS. We also searched clinical trials registries for ongoing and unpublished studies and checked reference lists to identify additional studies. RESULTS: We found 36 randomised controlled trials (2,073 patients) that met our inclusion criteria...
September 3, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/30201081/budget-impact-of-implementing-platelet-pathogen-reduction-into-the-italian-blood-transfusion-system
#6
Americo Cicchetti, Silvia Coretti, Francesco Sacco, Paolo Rebulla, Alessandra Fiore, Filippo Rumi, Rossella Di Bidino, Luz I Urbina, Pietro Refolo, Dario Sacchini, Antonio G Spagnolo, Emanuela Midolo, Giuseppe Marano, Blandina Farina, Ilaria Pati, Eva Veropalumbo, Simonetta Pupella, Giancarlo M Liumbruno
BACKGROUND: Despite improvements in blood donor selection and screening procedures, transfusion recipients can still develop complications related to infections by known and emerging pathogens. Pathogen reduction technologies (PRT) have been developed to reduce such risks. The present study, developed whithin a wider health technology assessment (HTA) process, was undertaken to estimate the costs of the continuing increase in the use of platelet PRT in Italy. MATERIALS AND METHODS: A multidisciplinary team was established to perform the HTA and conduct a budget impact analysis...
September 3, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/30036181/intravenous-immunoglobulin-replacement-treatment-reduces-in-vivo-elastase-secretion-in-patients-with-common-variable-immune-disorders
#7
Alessandro Prezzo, Filomena M Cavaliere, Cinzia Milito, Caterina Bilotta, Metello Iacobini, Isabella Quinti
BACKGROUND: Intravenous immunoglobulin (IVIg) treatment partially replaces antibody defects and modulates innate and adaptive immune cells in patients with primary antibody deficiencies. MATERIALS AND METHODS: This study was focused on the evaluation of the effects of in vivo IVIg administration on neutrophils from patients with common variable immune disorders (CVID). We examined polymorphonuclear neutrophil (PMN) phagocytosis, PMN oxidative burst, release of neutrophil elastase, serum level of interleukin-8 and PMN expression of CXCR1, CD11c and CD66b...
July 17, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/30036180/experience-with-rhd-weak-d-type-4-0-in-the-usa
#8
EDITORIAL
Connie M Westhoff, Sandra Nance, Christine Lomas-Francis, Margaret Keller, Stella T Chou
No abstract text is available yet for this article.
July 6, 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/30183614/blood-safety-policy-should-cautionary-policies-be-adopted-with-caution
#9
EDITORIAL
Luciana Riva, Carlo Petrini
No abstract text is available yet for this article.
September 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/30036178/prevalence-incidence-and-residual-risk-of-transfusion-transmitted-hepatitis-c-virus-and-human-immunodeficiency-virus-after-the-implementation-of-nucleic-acid-testing-in-italy-a-7-year-2009-2015-survey
#10
Claudio Velati, Luisa Romanò, Vanessa Piccinini, Giuseppe Marano, Liviana Catalano, Simonetta Pupella, Giuseppina Facco, Ilaria Pati, Maria Elena Tosti, Stefania Vaglio, Giuliano Grazzini, Alessandro Zanetti, Giancarlo M Liumbruno
BACKGROUND: In Italy nucleic acid testing (NAT) became mandatory for hepatitis C virus (HCV) in 2002 and for human immunodeficiency virus (HIV) and hepatitis B virus in 2008. The aim of this study was to monitor the incidence and prevalence of HIV and HCV infections in Italian blood donors and the current residual risk of these infections after the introduction of NAT. MATERIALS AND METHODS: The Italian national blood surveillance system includes data from tests used to screen for transfusion-transmissible infections...
September 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/30036177/cost-effectiveness-analysis-of-ferric-carboxymaltose-in-pre-operative-haemoglobin-optimisation-in-patients-undergoing-primary-knee-arthroplasty
#11
Misericordia Basora, Arturo Pereira, Miquel Coca, Montse Tió, Lluís Lozano
BACKGROUND: An analytic-decision model was built to estimate the cost-effectiveness of using ferric carboxymaltose for pre-operative haemoglobin optimisation in patients with iron deficiency anaemia undergoing primary knee arthroplasty. MATERIALS AND METHODS: We simulated 20,000 patients who were randomly assigned to the haemoglobin optimisation arm or the non-optimisation control arm in a strict 1:1 ratio. The main outcomes were cost per patient transfusion avoided and red blood cell units spared...
September 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29757135/a-nationwide-retrospective-study-on-prevalence-of-hepatitis-e-virus-infection-in-italian-blood-donors
#12
Enea Spada, Simonetta Pupella, Giulio Pisani, Roberto Bruni, Paola Chionne, Elisabetta Madonna, Umbertina Villano, Matteo Simeoni, Sara Fabi, Giuseppe Marano, Cinzia Marcantonio, Patrizio Pezzotti, Anna R Ciccaglione, Giancarlo M Liumbruno
BACKGROUND: In Europe, hepatitis E virus (HEV) infection is mainly a food-borne zoonosis, but it can also be transmitted by blood transfusion. It is usually a mild and self-limited infection. However, immunocompromised persons, who are also those more likely to undergo blood transfusions, may develop chronic hepatitis and often cirrhosis. Since this is a potential threat to blood safety, we aimed to investigate HEV prevalence in Italian blood donors. MATERIALS AND METHODS: We used plasma donations collected during 2015-2016 by blood services (BS) scattered throughout the Italian regions and intended for the production of plasma-derived medicines...
September 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29757133/haemolysis-index-for-the-screening-of-intravascular-haemolysis-a-novel-diagnostic-opportunity
#13
REVIEW
Giuseppe Lippi, Emmanuel J Favaloro, Massimo Franchini
The diagnostic approach to patients with intravascular haemolysis remains challenging, since no first-line laboratory test seems to be entirely suitable for the screening of this condition. Recent evidence shows that an enhanced cell-free haemoglobin (fHb) concentration in serum or plasma is a reliable marker of red blood cell injury, and may also predict clinical outcomes in patients with different forms of haemolytic anaemias. However, the routine use of the haemiglobincyanide assay, the current reference method for measuring fHb, seems unsuitable for a timely diagnosis of intravascular haemolysis, for many safety and practical reasons...
September 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29517973/molecular-immunohaematology-round-table-discussions-at-the-aabb-annual-meeting-orlando-2016
#14
Willy A Flegel, Qing Chen, Lilian Castilho, Margaret A Keller, Ellen B Klapper, William J Lane, France Pirenne, Gary Stack, Maryse St-Louis, Christopher A Tormey, Dan A Waxman, Christof Weinstock, Silvano Wendel, Gregory A Denomme
No abstract text is available yet for this article.
September 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29517971/non-factor-replacement-therapy-for-haemophilia-a-current-update
#15
REVIEW
Massimo Franchini, Pier Mannuccio Mannucci
One of the most challenging issues facing us in the treatment of haemophilia is the development of alloantibodies against infused factor VIII (FVIII) or factor IX (FIX). Inhibitors render factor replacement therapy ineffective, exposing patients to an unacceptably high risk of morbidity and mortality. Besides the well-known bypassing agents (i.e. activated prothrombin complex concentrate and recombinant activated factor VII) used to treat or prevent bleeding in haemophilia patients with inhibitors, there is growing interest in a new class of therapeutic agents which act by enhancing coagulation (i...
September 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29517963/non-replacement-therapy-for-haemophilia-treatment-fetching-the-east-by-the-west
#16
EDITORIAL
Marco Marietta, Mario Luppi
No abstract text is available yet for this article.
September 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29106357/position-paper-on-laboratory-testing-for-patients-on-direct-oral-anticoagulants-a-consensus-document-from-the-siset-fcsa-sibioc-and-sipmel
#17
Armando Tripodi, Walter Ageno, Marcello Ciaccio, Cristina Legnani, Giuseppe Lippi, Cesare Manotti, Rossella Marcucci, Marco Moia, Benedetto Morelli, Daniela Poli, Agostino Steffan, Sophie Testa
Although direct oral anticoagulants (DOAC) do not require dose-adjustment on the basis of laboratory test results, the measurement of their anticoagulant effect is useful in special situations. This position paper issued by the Italian Scientific Societies that are mainly involved in the management of patients on DOAC is aimed at providing guidance to care-givers on which tests should be used and the situations in which testing is useful. The guidance is based on the data from the literature so far available and/or on consensus among experts...
September 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29106354/characteristics-of-thawed-pooled-cryoprecipitate-stored-at-refrigerated-temperature-for-24-hours
#18
Esther P Soundar, Meredith Reyes, Laura Korte, Arthur Bracey
BACKGROUND: The need for thawed cryoprecipitate is growing. However, according to current guidelines, the shelf-life of pooled thawed cryoprecipitate at room temperature is limited because of possible bacterial contamination and loss of clotting factor activity. Here we assessed microbial growth and retention of clotting activity in cryoprecipitate stored at 4 °C after thawing to see whether its shelf life could be safely extended. MATERIALS AND METHODS: Pooled thawed cryoprecipitate units (n=10) were maintained at room temperature for 6 hours and then placed at 1-6 °C for 18 hours after thawing...
September 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29106353/testing-direct-oral-anticoagulants-embedding-in-structured-long-term-care
#19
EDITORIAL
Hugo Ten Cate
No abstract text is available yet for this article.
September 2018: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/29757134/second-line-therapy-in-paediatric-warm-autoimmune-haemolytic-anaemia-guidelines-from-the-associazione-italiana-onco-ematologia-pediatrica-aieop
#20
Saverio Ladogana, Matteo Maruzzi, Piera Samperi, Annalisa Condorelli, Maddalena Casale, Paola Giordano, Lucia D Notarangelo, Piero Farruggia, Fiorina Giona, Agostino Nocerino, Silvia Fasoli, Maria L Casciana, Maurizio Miano, Fabio Tucci, Tommaso Casini, Paola Saracco, Wilma Barcellini, Alberto Zanella, Silverio Perrotta, Giovanna Russo
No abstract text is available yet for this article.
July 2018: Blood Transfusion, Trasfusione del Sangue
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