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Blood Transfusion, Trasfusione del Sangue

Kirsty Rizzo, Kevin Vella, Daniel Zammit, Peter Gatt, Charlie Grima, Monique Borg Inguanez, Jurgen Gerada, Pierre Ellul, Mario Vassallo, Neville Azzopardi, James Pocock, Alex Gatt
BACKGROUND: Fibrinogen is produced in the liver and tends to be reduced in liver cirrhosis. Quantitative and qualitative tests exist to measure fibrinogen. We aimed to validate the functional fibrinogen thromboelastography assay (FF-TEG) and propose a new model to estimate fibrinogen levels via the Clauss method (Clauss) using data from a prothrombin time-derived fibrinogen assay (PT-Fg) in patients with liver cirrhosis. MATERIALS AND METHODS: Clauss, PT-Fg, fibrinogen antigen (Fib-Ag) and FF-TEG were studied in 55 patients with liver cirrhosis (26 with Child-Turcotte-Pugh [CTP]-A disease, 14 with CTP-B and 15 CTP-C) and 20 healthy individuals...
November 9, 2018: Blood Transfusion, Trasfusione del Sangue
Albert Farrugia
No abstract text is available yet for this article.
November 7, 2018: Blood Transfusion, Trasfusione del Sangue
David J Madrid, Manjula Santhanakrishnan, Jingchun Liu, David R Gibb, Dong Liu, Prabitha Natarajan, Daniel Beitler, Zhimin Shi, Chunyan Mo, Christopher A Tormey, Seema R Patel, Sean R Stowell, Jeanne E Hendrickson
BACKGROUND: Factors influencing the development of alloantibodies against blood group antigens on transfused red blood cells are poorly defined. We hypothesised that transfused platelets may act as a danger signal to recipients and affect humoral immune responses to transfused red blood cells. MATERIALS AND METHODS: Platelet-rich plasma prepared from wild-type C57BL/6 or CD40L knockout donors was transfused into wild-type or CD40L knock-out recipients. Leucoreduced red blood cells from transgenic donors expressing high levels of the human KEL glycoprotein in an erythrocyte-specific manner (KELhi donors) were transfused after the platelets, and anti-KEL responses were measured longitudinally...
November 7, 2018: Blood Transfusion, Trasfusione del Sangue
Walter Ageno, Anna Falanga, Giancarlo Castaman
No abstract text is available yet for this article.
November 7, 2018: Blood Transfusion, Trasfusione del Sangue
Houria El Housse, Mariam El Wafi, Zainab Ouabdelmoumene, Fatima Zarati, Rachida Alid, Nadia Nourichafi, Kamal Bouisk, Mohammed Benajiba, Claude Férec, Yann Fichou, Norddine Habti
BACKGROUND: To date, more than 650 (weak and partial) Rh variants have been reported. Nature and frequency of these variants are known to be ethnodependent. In transfusion medicine, their identification is important to ensure blood safety. The aim of this study is to investigate and describe the nature and estimate the frequency of Rh variants in blood donors in Morocco by serological tests and molecular analysis. MATERIALS AND METHODS: Blood samples from 4,458 blood donors were collected and typed for Rh antigens (D, C, c, E and e) by an automated system with monoclonal antibodies...
October 24, 2018: Blood Transfusion, Trasfusione del Sangue
Mariasanta Napolitano, Giorgia Saccullo, Marco Marietta, Monica Carpenedo, Giancarlo Castaman, Elisabetta Cerchiara, Antonio Chistolini, Laura Contino, Valerio De Stefano, Anna Falanga, Augusto B Federici, Elena Rossi, Rita Santoro, Sergio Siragusa
BACKGROUND: Management of venous thromboembolism (VTE) in patients with haematologic malignancies and thrombocytopenia is clinically challenging due to the related risks. No prospective studies or clinical trials have been carried out and, therefore, no solid evidence on this compelling issue is available. METHODS: Given this, an expert panel endorsed by the Gruppo Italiano Malattie Ematologiche dell'Adulto Working Party on Thrombosis and Haemostasis was set up to produce a formal consensus, according to the RAND method, in order to issue clinical recommendations about the platelet (PLT) cut-off for safe administration of low molecular weight heparin (LMWH) in thrombocytopenic (PLT <100×109 /L) adult patients with haematologic malignancies affected by acute (<1 month) or non-acute VTE...
October 24, 2018: Blood Transfusion, Trasfusione del Sangue
Susana Gómez-Ramírez, Aryeh Shander, Donat R Spahn, Michael Auerbach, Giancarlo M Liumbruno, Stefania Vaglio, Manuel Muñoz
Absolute or functional iron deficiency is the most prevalent cause of anaemia in surgical patients, and its correction is a fundamental strategy within "Patient Blood Management" programmes. Offering perioperative oral iron for treating iron deficiency anaemia is still recommended, but intravenous iron has been demonstrated to be superior in most cases. However, the long-standing prejudice against intravenous iron administration, which is thought to induce anaphylaxis, hypotension and shock, still persists...
October 16, 2018: Blood Transfusion, Trasfusione del Sangue
Elena Chinni, Giovanni Tiscia, Giovanni Favuzzi, Filomena Cappucci, Giuseppe Malcangi, Rossana Bagna, Claudia Izzi, Domenica Rizzi, Valerio De Stefano, Elvira Grandone
BACKGROUND: Congenital fibrinogen disorders are caused by variants occurring within the fibrinogen gene cluster. We describe ten subjects with disease-causative variants, adding information on such disorders. MATERIALS AND METHODS: Ten subjects were referred to our Centre because of likely hypo/dysfibrinogenaemia. We evaluated the function and quantity of fibrinogen, using Clauss and immunoreactive assays, and performed genetic investigations by direct sequencing of alpha, beta and gamma chain-encoding genes...
October 8, 2018: Blood Transfusion, Trasfusione del Sangue
Stephen J Wagner, Cheryl A Hapip, Annette Turgeon, Lenora Abel, Nadine Kaelber
BACKGROUND: The storage properties of apheresis platelets suspended in the experimental additive solution PAS-5 and 10% plasma may be affected by the collection instrument or storage container. METHODS AND EXPERIMENTAL DESIGN: The same consenting 12 donors provided A or T platelets with concurrent plasma on four occasions in 100% plasma. Following collection and resting, the platelets were centrifuged, and plasma was expressed and resuspended in PAS-5 to yield units with 10% plasma...
September 5, 2018: Blood Transfusion, Trasfusione del Sangue
Haobo Huang, Sha Jin, Xi Liu, Zhongying Wang, Qiong Lu, Liangfeng Fan, Wei Shen, Hang Lei, Chengrui Qian, Xuefeng Wang, Dong Xiang, Xiaohong Cai
BACKGROUND: A weak ABO subgroup is one of the most important causes of an ABO blood grouping discrepancy. Here, we investigated the distribution of weak ABO subgroups in the Chinese population and identified ten novel weak ABO subgroup alleles. MATERIAL AND METHODS: We performed phenotype investigations by serological studies, analysed the DNA sequence of the ABO gene by direct sequencing or sequencing after cloning, and evaluated the role of glycosyltransferase mutations by in silico analysis and in vitro expression assay...
September 3, 2018: Blood Transfusion, Trasfusione del Sangue
Nathan Clendenen, Adit Ginde
No abstract text is available yet for this article.
November 2018: Blood Transfusion, Trasfusione del Sangue
Massimo Franchini, Giancarlo M Liumbruno
No abstract text is available yet for this article.
November 2018: Blood Transfusion, Trasfusione del Sangue
Albert Farrugia, Giancarlo M Liumbruno, Fabio Candura, Samantha Profili, Josephine Cassar
Selecting therapeutic products for the treatment of haemophilia follows the process of obtaining market approval of products submitted to the scrutiny of a regulatory agency. In well-resourced countries, key decisions on whether a product is sufficiently safe and of high quality are made by highly expert and well-resourced agencies, such as the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA). In countries lacking such agencies, well-informed decisions can still be made through an appreciation of the key issues affecting the quality, safety and efficacy of haemophilia products...
November 2018: Blood Transfusion, Trasfusione del Sangue
Nuria Pérez-Jimeno, Manuel Muñoz, Jesús Mateo, Ana P Mayoral, Antonio Herrera
BACKGROUND: Total hip arthroplasty entails considerable peri-operative blood loss, which may lead to acute post-operative anaemia and red blood cell transfusion. This study was aimed at assessing whether the addition of topical tranexamic acid to our ongoing blood-saving protocol for total hip arthroplasty was effective and safe. MATERIALS AND METHODS: A pragmatic, prospective, open-label randomised study of patients scheduled for total hip arthroplasty at a single centre was conducted...
November 2018: Blood Transfusion, Trasfusione del Sangue
Massimo Franchini, Mario Cruciani, Carlo Mengoli, Giuseppe Marano, Simonetta Pupella, Eva Veropalumbo, Francesca Masiello, Ilaria Pati, Stefania Vaglio, Giancarlo M Liumbruno
BACKGROUND: The aim of this systematic review and meta-analysis was to evaluate the benefit of platelet-rich plasma (PRP) in non-surgical orthopaedic procedures. MATERIAL AND METHODS: We searched the Cochrane Wounds Specialized Register, CENTRAL, MEDLINE (through PUBMED), Embase, and SCOPUS. We also searched clinical trials registries for ongoing and unpublished studies and checked reference lists to identify additional studies. RESULTS: We found 36 randomised controlled trials (2,073 patients) that met our inclusion criteria...
November 2018: Blood Transfusion, Trasfusione del Sangue
Americo Cicchetti, Silvia Coretti, Francesco Sacco, Paolo Rebulla, Alessandra Fiore, Filippo Rumi, Rossella Di Bidino, Luz I Urbina, Pietro Refolo, Dario Sacchini, Antonio G Spagnolo, Emanuela Midolo, Giuseppe Marano, Blandina Farina, Ilaria Pati, Eva Veropalumbo, Simonetta Pupella, Giancarlo M Liumbruno
BACKGROUND: Despite improvements in blood donor selection and screening procedures, transfusion recipients can still develop complications related to infections by known and emerging pathogens. Pathogen reduction technologies (PRT) have been developed to reduce such risks. The present study, developed whithin a wider health technology assessment (HTA) process, was undertaken to estimate the costs of the continuing increase in the use of platelet PRT in Italy. MATERIALS AND METHODS: A multidisciplinary team was established to perform the HTA and conduct a budget impact analysis...
November 2018: Blood Transfusion, Trasfusione del Sangue
Silvia Manfroi, Chiara Calisesi, Pietro Fagiani, Annalisa Gabriele, Gianluca Lodi, Simonetta Nucci, Susanna Pelliconi, Laura Righini, Vanda Randi
BACKGROUND: Foetal RHD genotyping can be predicted by real-time polymerase chain reaction (qPCR) using cell-free foetal DNA extracted from maternal plasma. The object of this study was to determine the diagnostic accuracy and feasibility of non-invasive RHD foetal genotyping, using a commercial multiple-exon assay, as a guide to appropriate administration of targeted antenatal immunoprophylaxis. MATERIAL AND METHODS: Cell-free foetal DNA was extracted from plasma of RhD-negative women between 11-30 weeks of pregnancy...
November 2018: Blood Transfusion, Trasfusione del Sangue
Bert Avau, Emmy De Buck, Philippe Vandekerckhove, Veerle Compernolle
BACKGROUND: Blood transfusions save lives, but carry the risk of causing transfusion-transmitted diseases. This risk is limited by strict donor selection criteria, the most controversial being the exclusion of men who had sex with men (MSM). This cross-sectional study investigated knowledge and beliefs of the general public concerning donor exclusion criteria, with emphasis on MSM. MATERIALS AND METHODS: A representative sample of the population of Flanders, Belgium was questioned using a web-based questionnaire...
November 2018: Blood Transfusion, Trasfusione del Sangue
Gary Benson, Günter Auerswald, Gerry Dolan, Anne Duffy, Cedric Hermans, Rolf Ljung, Massimo Morfini, Silva Zupančić Šalek
Mild haemophilia is defined by factor levels between 0.05 and 0.40 IU/mL and is characterised by traumatic bleeds. Major issues associated with mild haemophilia are that it may not present for many years after birth, and that awareness, even within families, may be low. Methodological problems exist in diagnosis, such as inconsistencies in results obtained from different assays used to measure factor levels in mild haemophilia. Advances in genetic testing provide insight into diagnosis as well as the likelihood of inhibitor development, which is not uncommon in patients with mild or moderate haemophilia and can increase morbidity...
November 2018: Blood Transfusion, Trasfusione del Sangue
Grace Lim, Eleni Kotsis, Jamie M Zorn, Patricia L Dalby, Catherine J Ralph, Jonathan H Waters
BACKGROUND: The safety and effectiveness of cell salvage for vaginal delivery is unknown. This case series aimed to assess the utility and adverse events related to the use of cell salvage for maternal haemorrhage during vaginal delivery. MATERIALS AND METHODS: A cohort study design was chosen, focused on postpartum haemorrhages that occurred after vaginal delivery for which cell salvage equipment was requested to be set up in the labour and delivery room outside of a sterile operating room environment...
November 2018: Blood Transfusion, Trasfusione del Sangue
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