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Blood Transfusion, Trasfusione del Sangue

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https://www.readbyqxmd.com/read/28287381/a-preliminary-evaluation-of-next-generation-sequencing-as-a-screening-tool-for-targeted-genotyping-of-erythrocyte-and-platelet-antigens-in-blood-donors
#1
Agnieszka Orzińska, Katarzyna Guz, Michał Mikula, Maria Kulecka, Anna Kluska, Aneta Balabas, Monika Pelc-Kłopotowska, Jerzy Ostrowski, Ewa Brojer
BACKGROUND: Matching the compatibility of donor blood with the recipient's antigens prevents alloimmunisation. Next-generation sequencing (NGS) technology is a promising method for extensive blood group and platelet antigen genotyping of blood donors. It circumvents the limitations of detecting known alleles based on predefined polymorphisms and enables targeted sequencing on a massive scale. The aim of this study was to evaluate the NGS AmpliSeq application on the Ion Torrent platform as a screening tool for genotyping blood donors' erythrocyte/platelet antigens...
March 10, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287383/fibrinogen-concentrate-in-surgery
#2
Giuseppe Marano, Carlo Mengoli, Massimo Franchini, Stefania Vaglio, Sara Gentili, Simonetta Pupella, Giancarlo M Liumbruno
No abstract text is available yet for this article.
March 9, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287378/application-of-a-clot-based-assay-to-measure-the-procoagulant-activity-of-stored-allogeneic-red-blood-cell-concentrates
#3
Bérangère Devalet, Adeline Wannez, Nicolas Bailly, Lutfiye Alpan, Damien Gheldof, Jonathan Douxfils, Véronique Deneys, Benoît Bihin, Bernard Chatelain, Jean-Michel Dogné, Christian Chatelain, François Mullier
BACKGROUND: Thrombotic effects are possible complications of red blood cell transfusion. The generation and accumulation of procoagulant red blood cell extracellular vesicles during storage may play an important role in these thrombotic effects. The objective of this study was to assess the value of a simple phospholipid-dependent clot-based assay (STA(®)-Procoag-PPL) to estimate the procoagulant activity of stored red blood cells and changes in this activity during storage of the blood component...
March 9, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287385/interference-of-direct-oral-anticoagulants-in-haemostasis-assays-high-potential-for-diagnostic-false-positives-and-false-negatives
#4
EDITORIAL
Emmanuel J Favaloro, Giuseppe Lippi
No abstract text is available yet for this article.
March 7, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287382/effect-of-dabigatran-on-a-prothrombinase-based-assay-for-detecting-activated-protein-c-resistance-an-ex-vivo-and-in-vitro-study-in-normal-subjects-and-factor-v-leiden-carriers
#5
Gianluca Gessoni, Sara Valverde, Letizia Valle, Pierpaolo Caruso, Francesca Gessoni, Roberto Valle
BACKGROUND: The aim of this study was to evaluate ex vivo and in vitro interference of a direct factor IIa inhibitor, dabigatran, on a prothrombinase-based assay to detect activated protein C resistance. MATERIALS AND METHODS: An ex vivo study was performed in six heterozygous factor V Leiden carriers and 12 normal subjects without the factor V Leiden mutation who were treated with dabigatran. An in vitro study was also performed considering 12 plasma samples (six from normal subjects and six from heterozygous factor V Leiden carriers) spiked with dabigatran...
March 7, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287386/recommendations-for-factor-viii-product-source-to-treat-patients-with-haemophilia-a
#6
LETTER
Romano Arcieri, Gabriele Calizzani, Fabio Candura, Pier Mannuccio Mannucci
No abstract text is available yet for this article.
March 2, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287380/the-increased-demand-for-plasma-derived-factor-viii-in-italy-between-2011-and-2014-is-attributable-to-treatment-of-adult-patients-rather-than-paediatric-or-previously-unexposed-patients-with-severe-haemophilia-a
#7
LETTER
Antonio Coppola, Elena Santagostino, Hamisa J Hassan, Angelo C Molinari, Rita C Santoro, Annarita Tagliaferri, Massimo Morfini, Giovanni Di Minno
No abstract text is available yet for this article.
March 2, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287376/increase-of-plasma-concentration-to-10-improves-a-number-of-in-vitro-storage-parameters-of-apheresis-platelets-suspended-in-a-bicarbonate-containing-additive-solution-and-stored-with-a-24-hour-interruption-of-agitation
#8
Stephen J Wagner, Andrey Skripchenko, Cheryl A Hapip, Nadine Kaelber, Annette Turgeon
BACKGROUND: A previous study demonstrated several pH failures during 7-day storage of platelets suspended in 5% plasma/95% PAS-5 following a 24-hour interruption of agitation. The aim of this study was to investigate whether pH control improves in platelets stored in PAS-5 with 10% plasma following interruption of agitation. MATERIALS AND METHODS: Four aliquots were prepared from a single unit of apheresis platelets: two each with 5% and 10% plasma. After resting for 1 hour, the aliquots were placed on an agitator...
March 2, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287384/effects-of-potassium-adsorption-filters-on-the-removal-of-ammonia-from-blood-products
#9
Hiroshi Fujita, Yoko Shiotani, Yuko Takada, Shigeko Nishimura
BACKGROUND: Although ammonia in plasma does not usually pass through the blood-brain barrier (BBB), in cases of traumatic brain injury it may do so, acting as a neurotoxin on the brain. Excess intake of ammonia should be restricted in conditions involving BBB breakdown, such as traumatic brain injury. Washing is a method to remove ammonia from blood products, but fresh-frozen plasma and albumin products cannot be washed. A potassium adsorption filter (PAF) can remove not only potassium, but also ammonia from red blood cell solutions...
March 1, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287379/k-antigen-blocking-in-a-case-of-haemolytic-disease-of-the-foetus-and-newborn
#10
LETTER
Silvia Manfroi, Claudio Velati
No abstract text is available yet for this article.
February 3, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287377/use-of-dabigatran-and-rivaroxaban-in-non-valvular-atrial-fibrillation-one-year-follow-up-experience-in-an-italian-centre
#11
Mario Schiavoni, Maurizio Margaglione, Antonella Coluccia
BACKGROUND: Direct oral anticoagulants (DOAC) have been shown to be non-inferior to traditional vitamin K antagonists in preventing stroke and arterial thromboembolism in patients with non-valvular atrial fibrillation. Nevertheless, it is mandatory to record side effects and individual adherence to DOAC treatment. MATERIALS AND METHODS: In this single-centre experience, patients with non-valvular atrial fibrillation were prospectively observed after switching from a vitamin K antagonist to dabigatran or rivaroxaban...
January 31, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28151395/molecular-basis-of-the-duffy-blood-group-system
#12
REVIEW
Gabriela Höher, Marilu Fiegenbaum, Silvana Almeida
ACKR1, located on chromosome 1q23.2, is the gene that encodes a glycoprotein expressing the Duffy blood group antigens. This gene is transcribed in two mRNA variants yielding two isoforms, encoding proteins with 338 and 336 amino acids. This review provides a general overview of the Duffy blood group to characterise and elucidate the genetic basis of this system. The Fy(a) and Fy(b) antigens are encoded by co-dominant FY*A (FY*01) and FY*B (FY*02) alleles, which differ by c.125G>A (rs12075), defining the Fy(a+b-), Fy(a-b+) and Fy(a+b+) phenotypes...
January 30, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28151388/peri-operative-treatment-of-anaemia-in-major-orthopaedic-surgery-a-practical-approach-from-spain
#13
REVIEW
Elvira Bisbe, Misericordia Basora, María J Colomina
In patients undergoing major orthopaedic surgery, pre-operative anaemia, peri-operative bleeding and a liberal transfusion policy are the main risk factors for requiring red blood cell transfusion (RBCT). The clinical and economic disadvantages of RBCT have led to the development and implementation of multidisciplinary, multimodal, individualised strategies, collectively termed patient blood management, which aim to reduce RBCT and improve patients' clinical outcome and safety. Within a patient blood management programme, low pre-operative haemoglobin is one of the few modifiable risk factors for RBCT...
January 26, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28151385/transfusion-associated-circulatory-overload-in-adult-medical-emergency-patients-with-perspectives-on-early-warning-practice-a-single-centre-clinical-study
#14
Fanny Gosmann, Astrid Nørgaard, Maj-Britt Rasmussen, Charlotte Rahbek, Jens Seeberg, Tom Møller
BACKGROUND: Transfusion-associated circulatory overload is characterised by acute respiratory distress, tachycardia, increased blood pressure, acute pulmonary oedema and/or evidence of positive fluid balance occurring within 6 hours after transfusion. Transfusion-associated circulatory overload is a serious, underreported reaction, which makes this iatrogenic condition difficult to prevent. We present an audit of patients admitted to a medical emergency unit, aiming to investigate: (i) the incidence of transfusion-associated circulatory overload; and (ii) whether cases were reported to the haemovigilance system...
January 26, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28151392/the-age-of-stored-erythrocytes-influences-methaemoglobin-formation-when-circulated-in-a-heart-lung-machine-model
#15
Lea Krampen, Stefanie Krajewski, Heike Roth, Rupert Handgretinger, Christian Schlensak, Gernot Bruchelt, Hans P Wendel
No abstract text is available yet for this article.
January 25, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28151387/bidirectional-inefficacy-or-intolerability-of-thrombopoietin-receptor-agonists-new-data-and-a-concise-review
#16
Fabian Depré, Nasra Aboud, Beate Mayer, Abdulgabar Salama
BACKGROUND: There is evidence that the thrombopoietin-receptor agonists romiplostim and eltrombopag may have different therapeutic values and adverse reaction profiles. Here we present new data and provide a review of all studies dealing with switching between these two drugs. MATERIALS AND METHODS: A total of 89 patients (38 males and 51 females, aged between 14-87 years) were treated with eltrombopag and/or romiplostim between 2007 and 2016 at our institution...
January 25, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28151394/a-fast-track-anaemia-clinic-in-the-emergency-department-cost-analysis-of-intravenous-iron-administration-for-treating-iron-deficiency-anaemia
#17
Manuel Quintana-Díaz, Raúl Muñoz-Romo, Susana Gómez-Ramírez, José Pavía, Alberto M Borobia, José A García-Erce, Manuel Muñoz
BACKGROUND: A fast-track anaemia clinic (FTAC) for the management of moderate-to-severe iron-deficiency anaemia (IDA) was established in our Emergency Department in 2010. In this FTAC, the replacement of packed red cell transfusion by ferric carboxymaltose administration was proven to be safe and effective. The aim of this study was a cost-analysis of IDA management in the FTAC, comparing this management with the previous standard care pathway consisting of packed red cell transfusion, if needed, and referral to outpatient specialised care...
January 24, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28151386/clinical-experience-reversing-factor-xa-inhibitors-with-four-factor-prothrombin-complex-concentrate-in-a-community-hospital
#18
Katie B Tellor, Naomi S Barasch, Brian M Lee
No abstract text is available yet for this article.
January 24, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28263179/interpreting-the-deluge-of-omics-data-new-approaches-offer-new-possibilities
#19
LETTER
Aarash Bordbar
No abstract text is available yet for this article.
March 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28263178/the-3-phase-evolution-of-stored-red-blood-cells-and-the-clinical-trials-an-obvious-relationship
#20
LETTER
Michel Prudent, Jean-Daniel Tissot, Niels Lion
No abstract text is available yet for this article.
March 2017: Blood Transfusion, Trasfusione del Sangue
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