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Blood Transfusion, Trasfusione del Sangue

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https://www.readbyqxmd.com/read/28686155/paediatric-venous-thromboembolism-a-report-from-the-italian-registry-of-thrombosis-in-children-riti
#1
Paola Giordano, Massimo Grassi, Paola Saracco, Angelo C Molinari, Chiara Gentilomo, Agnese Suppiej, Giuseppe Indolfi, Donatella Lasagni, Matteo Luciani, Fiammetta Piersigilli, Maria C Putti, Lidia L Rota, Stefano Sartori, Paolo Simioni
BACKGROUND: The Italian Registry of Thrombosis in Children (RITI) was established by a multidisciplinary team with the aims of improving knowledge about neonatal and paediatric thrombotic events in Italy and providing a preliminary source of data for the future development of specific clinical trials and diagnostic-therapeutic protocols. MATERIALS AND METHODS: We analysed the subset of RITI data concerning paediatric systemic venous thromboembolic events that occurred between January 2007 and June 2013...
June 30, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28686150/use-of-fresh-frozen-plasma-in-2012-at-the-fondazione-ca-granda-hospital-of-milan-assessment-of-appropriateness-using-record-linkage-techniques-applied-to-data-routinely-recorded-in-various-hospital-information-systems
#2
Monica Lanzoni, Barbara Olivero, Andrea Artoni, Maurizio Marconi, Elisabetta Raspollini, Silvana Castaldi
BACKGROUND: The Quality Unit of a research and teaching hospital in Milan assessed the increased clinical use of fresh-frozen plasma in patients treated during 2012 in order to evaluate the appropriateness of this use. MATERIALS AND METHODS: For each patient in the study, a pathology profile was generated by means of record linkage techniques involving data collected through different information systems. Patients' information was combined using the patient identifier key generating pathology profiles exported to an Excel file...
June 19, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28686151/individual-contextual-and-network-characteristics-of-blood-donors-and-non-donors-a-systematic-review-of-recent-literature
#3
REVIEW
Tjeerd W Piersma, René Bekkers, Elisabeth F Klinkenberg, Wim L A M De Kort, Eva-Maria Merz
BACKGROUND: The ageing population and recent migration flows may negatively affect the blood supply in the long term, increasing the importance of targeted recruitment and retention strategies to address donors. This review sought to identify individual, network and contextual characteristics related to blood donor status and behaviour, to systematically discuss differences between study results, and to identify possible factors to target in recruitment and retention efforts. METHODS: The systematic review was conducted in accordance with a predefined PROSPERO protocol (CRD42016039591)...
June 13, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28686153/heparin-like-effect-resistant-to-protamine-in-a-child-with-haemorrhagic-shock-do-we-need-heparinase
#4
Mirco Nacoti, Diego Cantù, Daniele Bonacina, Federico Lussana, Ezio Bonanomi, Marina Marchetti, Anna Falanga
No abstract text is available yet for this article.
June 8, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28686149/enhanced-opsonisation-of-rhesus-d-positive-human-red-blood-cells-by-recombinant-polymeric-immunoglobulin-g-anti-g-antibodies
#5
Dylana Díaz-Solano, Jaheli Fuenmayor, Ramon F Montaño
BACKGROUND: Anti-RhD antibodies (anti-D) are important in the prophylaxis of haemolytic disease of the foetus and newborn (HDFN) due to RhD incompatibility. Current preparations of anti-D are sourced from hyperimmune human plasma, so its production carries a risk of disease and is dependent on donor availability. Despite the efforts to develop a monoclonal preparation with similar prophylactic properties to the plasma-derived anti-D, no such antibody is yet available. Here we studied the agglutinating, opsonic and haemolytic activities of two recombinant polymeric immunoglobulins (Ig) against the G antigen of the Rh complex...
May 30, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28686158/diagnosis-and-management-of-patients-with-von-willebrand-s-disease-in-italy-an-expert-meeting-report
#6
EDITORIAL
Flora Peyvandi
No abstract text is available yet for this article.
May 26, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28665269/improving-the-safety-of-whole-blood-derived-transfusion-products-with-a-riboflavin-based-pathogen-reduction-technology
#7
REVIEW
Susan Yonemura, Suzann Doane, Shawn Keil, Raymond Goodrich, Heather Pidcoke, Marcia Cardoso
Worldwide safety of blood has been positively impacted by technological, economic and social improvements; nevertheless, growing socio-political changes of contemporary society together with environmental changes challenge the practice of blood transfusion with a continuous source of unforeseeable threats with the emergence and re-emergence of blood-borne pathogens. Pathogen reduction (PR) is a proactive strategy to mitigate the risk of transfusion-transmitted infections. PR technologies for the treatment of single plasma units and platelet concentrates are commercially available and have been successfully implemented in more than 2 dozen countries worldwide...
July 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28661856/the-use-of-fibrinogen-concentrate-for-the-management-of-trauma-related-bleeding-a-systematic-review-and-meta-analysis
#8
REVIEW
Carlo Mengoli, Massimo Franchini, Giuseppe Marano, Simonetta Pupella, Stefania Vaglio, Marco Marietta, Giancarlo M Liumbruno
Haemorrhage following injury is associated with significant morbidity and mortality. The role of fibrinogen concentrate in trauma-induced coagulopathy has been the object of intense research in the last 10 years and has been systematically analysed in this review. A systematic search of the literature identified six retrospective studies and one prospective one, involving 1,650 trauma patients. There were no randomised trials. Meta-analysis showed that fibrinogen concentrate has no effect on overall mortality (risk ratio: 1...
July 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28661855/red-blood-cell-transfusion-policy-a-critical-literature-review
#9
REVIEW
Massimo Franchini, Giuseppe Marano, Carlo Mengoli, Simonetta Pupella, Stefania Vaglio, Manuel Muñoz, Giancarlo M Liumbruno
The issue of the most appropriate red blood cell transfusion policy has been addressed by a number of randomised controlled trials, conducted over the last decades, comparing the effects on patients' outcome of restrictive blood transfusion strategies (transfusing when the haemoglobin concentration is less than 7 g/dL to 8 g/dL) vs more liberal ones (transfusing when the haemoglobin concentration is less than 9 g/dL to 10 g/dL) in a variety of clinical settings. In parallel, various systematic reviews and meta-analyses have tried to perform pooled analyses of the data from these randomised controlled trials and their results have been utilised by scientific societies to provide recommendations and guidelines on red blood cell transfusion thresholds...
July 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28488975/the-italian-regulatory-guidelines-for-the-implementation-of-patient-blood-management
#10
Stefania Vaglio, Sara Gentili, Giuseppe Marano, Simonetta Pupella, Daniela Rafanelli, Gianni Biancofiore, Paola Antonioli, Claudio Velati, Giancarlo M Liumbruno
No abstract text is available yet for this article.
July 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28488973/a-pathogen-reduction-clinical-trial-in-retrospect
#11
Paolo Rebulla
No abstract text is available yet for this article.
July 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28488963/towards-the-implementation-of-patient-blood-management-across-europe
#12
EDITORIAL
Massimo Franchini, Manuel Muñoz
No abstract text is available yet for this article.
July 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28488957/cumulative-erythrocyte-damage-in-blood-storage-and-relevance-to-massive-transfusions-selective-insights-into-serial-morphological-and-biochemical-findings
#13
REVIEW
Jeffrey S Putter, Jerard Seghatchian
Elucidating the precise mechanisms of cumulative red cell damages during storage and the potential harmful consequences after transfusion are achievable by exacting laboratory science and well-defined clinical studies in progress. Accordingly, for larger magnitude blood transfusions (i.e. 8-12 U in 24 hours), the quality of the stored blood and its characterisation are of special academic and clinical importance. Our main objectives in this review are to illuminate facets of the red cell storage lesion for prolonged storage (0-42 days) by concentrating on various hallmarks of the disorder: 1) identifying and characterising serial markers of the progressive lesion with respect to red cell dysmorphology, deformability, haemolytic fragility and dysfunction both in storage and the microcirculation; and 2) relevant biochemical findings of redox status correlated to oxidative stress of erythrocyte proteins...
July 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28151388/peri-operative-treatment-of-anaemia-in-major-orthopaedic-surgery-a-practical-approach-from-spain
#14
REVIEW
Elvira Bisbe, Misericordia Basora, María J Colomina
In patients undergoing major orthopaedic surgery, pre-operative anaemia, peri-operative bleeding and a liberal transfusion policy are the main risk factors for requiring red blood cell transfusion (RBCT). The clinical and economic disadvantages of RBCT have led to the development and implementation of multidisciplinary, multimodal, individualised strategies, collectively termed patient blood management, which aim to reduce RBCT and improve patients' clinical outcome and safety. Within a patient blood management programme, low pre-operative haemoglobin is one of the few modifiable risk factors for RBCT...
July 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28151384/peri-operative-anaemia-management-in-major-orthopaedic-surgery-the-need-to-find-a-pathway
#15
EDITORIAL
Manuel Muñoz, Susana Gómez-Ramírez, Giancarlo M Liumbruno
No abstract text is available yet for this article.
July 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27893358/the-price-of-enhanced-half-life-factor-ix
#16
LETTER
Andrea Messori, Sabrina Trippoli
No abstract text is available yet for this article.
July 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27643751/cryopreserved-packed-red-blood-cells-in-surgical-patients-past-present-and-future
#17
REVIEW
Alex Chang, Young Kim, Richard Hoehn, Peter Jernigan, Timothy Pritts
Since the advent of anticoagulation and component storage of human blood products, allogeneic red blood cell transfusion has been one of the most common practices in modern medicine. Efforts to reduce the biochemical effects of storage, collectively known as the red blood cell storage lesion, and prolong the storage duration have led to numerous advancements in erythrocyte storage solutions. Cryopreservation and frozen storage of red blood cells in glycerol have been successfully utilised by many civilian and military institutions worldwide...
July 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27483484/porcine-recombinant-factor-viii-an-additional-weapon-to-handle-anti-factor-viii-antibodies
#18
REVIEW
Pier Mannuccio Mannucci, Massimo Franchini
This review focuses on the use of recombinant porcine factor VIII (FVIII) for the treatment of bleeding episodes in patients with severe haemophilia A complicated by inhibitors and in those with acquired haemophilia A due to the onset of anti-FVIII autoantibodies. We present the main characteristics of recombinant porcine factor VIII (FVIII) and provide a summary of the published results of the clinical studies of this novel recombinant FVIII. There is a special emphasis on how the use of recombinant porcine factor VIII (FVIII) is expected to improve the clinical management of these patients...
July 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27483482/platelet-gel-a-new-therapeutic-tool-with-great-potential
#19
REVIEW
Andrea Piccin, Angela M Di Pierro, Lucia Canzian, Marco Primerano, Daisy Corvetta, Giovanni Negri, Guido Mazzoleni, Günther Gastl, Michael Steurer, Ivo Gentilini, Klaus Eisendle, Fabrizio Fontanella
Chronic wounds, such as diabetic foot ulcers, represent a serious clinical problem for patients and clinicians. Management of these wounds has a strong economic impact worldwide. Complications resulting from injuries are a frequent cause of morbidity and mortality. Chronic wounds lead to infections, painful dressings and prolonged hospitalisation. This results in poor patient Quality of Life and in high healthcare costs. Platelet concentrates (PC) are defined as autologous or allogeneic platelet derivatives with a platelet concentration higher than baseline...
July 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27483479/anticoagulants-for-the-prevention-and-treatment-of-catheter-related-thrombosis-in-adults-and-children-on-parenteral-nutrition-a-systematic-review-and-critical-appraisal
#20
REVIEW
Stefano Barco, Jasper J Atema, Michiel Coppens, Mireille J Serlie, Saskia Middeldorp
BACKGROUND: Patients on parenteral nutrition require a central venous access and are at risk of catheter-related thrombosis, pulmonary embolism, and vena cava syndrome. Parenteral nutrition guidelines suggest anticoagulation for the primary prevention of catheter-related thrombosis during long-term parenteral nutrition. We conducted a systematic review of the efficacy, safety and feasibility of anticoagulant use for preventing and treating catheter-related thrombosis during parenteral nutrition...
July 2017: Blood Transfusion, Trasfusione del Sangue
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