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Blood Transfusion, Trasfusione del Sangue

Seyma Colakoglu, Turan Bayhan, Betül Tavil, Ebru Yılmaz Keskin, Volkan Cakir, Fatma Gümrük, Mualla Çetin, Selin Aytaç, Ergul Berber
BACKGROUND: Factor XI (FXI) deficiency is an autosomal bleeding disease associated with genetic defects in the F11 gene which cause decreased FXI levels or impaired FXI function. An increasing number of mutations has been reported in the FXI mutation database, most of which affect the serine protease domain of the protein. FXI is a heterogeneous disorder associated with a variable bleeding tendency and a variety of causative F11 gene mutations. The molecular basis of FXI deficiency in 14 patients from ten unrelated families in Turkey was analysed to establish genotype-phenotype correlations and inheritance of the mutations in the patients' families...
October 4, 2016: Blood Transfusion, Trasfusione del Sangue
Hervé Hourlier, Peter Fennema
BACKGROUND: The effect of tranexamic acid has not been examined in patients who are regular users of antithrombotics before undergoing total knee arthroplasty. The aim of this study was to determine the impact of tranexamic acid on bleeding and the risk of transfusion and thrombosis in patients taking an antithrombotic treatment before primary unilateral total knee arthroplasty. MATERIAL AND METHODS: A prospective observational study was conducted in a series of 385 consecutive primary total knee arthroplasties performed with and without the administration of tranexamic acid...
October 4, 2016: Blood Transfusion, Trasfusione del Sangue
Massimo Franchini, Pier Mannuccio Mannucci
No abstract text is available yet for this article.
October 4, 2016: Blood Transfusion, Trasfusione del Sangue
Alice Trinchero, Marina Marchetti, Cinzia Giaccherini, Carmen J Tartari, Laura Russo, Anna Falanga
BACKGROUND: Patients with thalassaemia may have thromboembolic events and, even without thrombosis, they have a subclinical hypercoagulable state. In this setting, several coagulation laboratory abnormalities have been described, but thus far no studies have explored the contribution of platelet adhesive and procoagulant properties to blood clotting activation. In this study, we dissected the platelet procoagulant effect and influence of blood transfusions on haemostasis and platelet function in thalassaemic patients...
October 4, 2016: Blood Transfusion, Trasfusione del Sangue
Thomas Volken, Andreas Buser, Damiano Castelli, Stefano Fontana, Beat M Frey, Ilka Rüsges-Wolter, Amira Sarraj, Jörg Sigle, Jutta Thierbach, Tina Weingand, Behrouz Mansouri Taleghani
BACKGROUND: Several studies have raised concerns that future demand for blood products may not be met. The ageing of the general population and the fact that a large proportion of blood products is transfused to elderly patients has been identified as an important driver of blood shortages. The aim of this study was to collect, for the first time, nationally representative data regarding blood donors and transfusion recipients in order to predict the future evolution of blood donations and red blood cell (RBC) use in Switzerland between 2014 and 2035...
September 30, 2016: Blood Transfusion, Trasfusione del Sangue
Benedetta Mazzanti, Serena Urbani, Simone Dal Pozzo, Paola Bufano, Lara Ballerini, Alessia Gelli, Irene Sodi, Irene Donnini, Massimo Di Gioia, Stefano Guidi, Julien Camisani, Riccardo Saccardi
BACKGROUND: Clinical grade processing of harvested bone marrow is required in various clinical situations, particularly in the management of ABO mismatching in allogeneic haematopoietic stem cell transplantation (HSCT) and in regenerative medicine. MATERIAL AND METHODS: We report a single-centre experience using a fully automated, clinical grade, closed system (Sepax, Biosafe, Switzerland). From 2003 to 2015, 125 procedures were performed in our laboratory, including buffy-coat production for HSCT (n=58), regenerative medicine in an orthopaedic setting (n=54) and density-gradient separation in a trial for treatment of critical limb ischaemia (n=13)...
September 27, 2016: Blood Transfusion, Trasfusione del Sangue
Ryanne W Lieshout-Krikke, Dragoslav Domanovic, Wim De Kort, Wolfgang Mayr, Giancarlo M Liumbruno, Simonetta Pupella, Johann Kurz, Folke Knutson, Sheila Maclennan, Gilles Folléa
BACKGROUND: Two selection strategies for newly-registered blood donors are available: a single-visit selection called the standard selection procedure (SSP), and a two-stage selection named pre-donation and donation screening (PDS). This study reviews the selection strategies for newly-registered donors currently applied in European countries. MATERIAL AND METHODS: We collected data on donor selection procedures, blood donation, laboratory screening and HIV, HCV and HBV positive donors/donations from 2010 to 2013 in 30 European countries by using questionnaires...
September 27, 2016: Blood Transfusion, Trasfusione del Sangue
Per Sandgren
No abstract text is available yet for this article.
September 22, 2016: Blood Transfusion, Trasfusione del Sangue
Carlo Petrini
No abstract text is available yet for this article.
September 21, 2016: Blood Transfusion, Trasfusione del Sangue
Chaker Aloui, Tahar Chakroun, Antoine Prigent, Saloua Jemni-Yacoub, Fabrice Cognasse, Sandrine Laradi, Olivier Garraud
BACKGROUND: Leucoreduction of blood components, including platelet components, is strongly encouraged but not yet universal, especially outside high income countries. As both leucocytes and platelets secrete copious amounts of pro-inflammatory cytokines/chemokines under various conditions and during storage, we investigated the potential of the respective secretory programmes of these cells in order to evaluate their subsequent pathophysiological effects. MATERIAL AND METHODS: A total of 158 individual non-leucoreduced platelet components were obtained from Tunisian donors and tested for characteristic biological response modifiers (BRM) of leukocytes (IL-1β, IL-8), platelets (sCD62P, sCD40L) and both cell types (TNF-α, RANTES) in the presence or absence of thrombin stimulation and after different periods of storage (up to 5 days)...
September 8, 2016: Blood Transfusion, Trasfusione del Sangue
Alex Chang, Young Kim, Richard Hoehn, Peter Jernigan, Timothy Pritts
Since the advent of anticoagulation and component storage of human blood products, allogeneic red blood cell transfusion has been one of the most common practices in modern medicine. Efforts to reduce the biochemical effects of storage, collectively known as the red blood cell storage lesion, and prolong the storage duration have led to numerous advancements in erythrocyte storage solutions. Cryopreservation and frozen storage of red blood cells in glycerol have been successfully utilised by many civilian and military institutions worldwide...
September 8, 2016: Blood Transfusion, Trasfusione del Sangue
Tomislav Vuk, Karin Magnussen, Wim De Kort, Gilles Folléa, Giancarlo M Liumbruno, Harald Schennach, Giovani Vandewalle, Veerle Compernolle, Natalia Masharova, Georgia Karakatsiani, Isabella Argyrou, Vít Řeháček, Gulara Khanirzajeva, Johanna Castrén, Bruno Danic, Rachid Djoudi, Geneviève Woimant, Markus M Mueller, Constantina Politis, Stefania Vaglio, Anita Daugavvanaga, Edita Vilutyte, Jean-Claude Faber, Denise Borg-Aquilina, Peter Van Den Burg, Arlinke Bokhorst, Ryszard Pogłód, Jolanta Antoniewicz-Papis, Mario Muon, Olivia L Burta, Jana Rosochová, Polonca Mali, Miguel A Vesga, Karin Schneider, Rut Norda, Nicky Anderson
No abstract text is available yet for this article.
September 7, 2016: Blood Transfusion, Trasfusione del Sangue
Willy A Flegel, Lilian Castilho, Wm Andrew L Heaton, Margaret A Keller, Ellen B Klapper, William J Lane, France Pirenne, Nadine Shehata, Gary Stack, Maryse St-Louis, Christopher A Tormey, Franz F Wagner, Dan A Waxman, Gregory A Denomme
No abstract text is available yet for this article.
July 29, 2016: Blood Transfusion, Trasfusione del Sangue
Romano Arcieri, Gabriele Calizzani, Fabio Candura, Pier Mannuccio Mannucci
No abstract text is available yet for this article.
July 28, 2016: Blood Transfusion, Trasfusione del Sangue
Claudia Stefanutti, Claudia Morozzi
No abstract text is available yet for this article.
September 2016: Blood Transfusion, Trasfusione del Sangue
Mareike K Körber, Elisabeth Langer, Lutz Kaufner, Michael Sander, Christian Von Heymann
BACKGROUND: A bleeding patient undergoing therapy with new oral anticoagulants is every clinician's nightmare as no specific reversal agent is available yet. This in vitro study investigated the effect of prothrombin complex concentrate (PCC), recombinant activated factor VII (rFVIIa) and activated prothrombin complex concentrate (aPCC) on supratherapeutic rivaroxaban concentrations using standard laboratory parameters (prothrombin time [PT], activated partial thromboplastin time [aPTT] and PT ratio) and thromboelastometry (clotting time [CT])...
September 2016: Blood Transfusion, Trasfusione del Sangue
Claudia Blais, Marc Germain, Gilles Delage, Yves Grégoire
BACKGROUND: The association between antigens A and B and arterial thrombosis, such as coronary heart disease, cerebrovascular disease or peripheral vascular disease, is still unclear. We evaluated the association between blood groups and thrombotic events in a cohort of blood donors from the province of Quebec, Canada. MATERIAL AND METHODS: Among all whole blood donors aged ≥18 years in Quebec between June 1990 and March 2009, a study sample with known blood groups was linked with the provincial hospitalisation and death records to count vascular events...
September 2016: Blood Transfusion, Trasfusione del Sangue
Massimo Franchini, Carlo Mengoli, Giuseppe Lippi
Given the expression of ABO blood group antigens on the surface of a wide range of human cells and tissues, the putative interplay of the ABO system in human biology outside the area of transfusion and transplantation medicine constitutes an intriguing byway of research. Thanks to evidence accumulated over more than 50 years, the involvement of the ABO system in the pathogenesis of several human diseases, including cardiovascular, infectious and neoplastic disorders, is now acknowledged. However, there is controversial information on the potential association between ABO blood type and adverse pregnancy outcomes, including pre-eclampsia and related disorders (eclampsia, HELLP syndrome and intrauterine growth restriction), venous thromboembolism, post-partum haemorrhage and gestational diabetes...
September 2016: Blood Transfusion, Trasfusione del Sangue
Ane C Gaspardi, Emília A Sippert, Mayra Dorigan De Macedo, Jordão Pellegrino, Fernando F Costa, Lilian Castilho
BACKGROUND: As a consequence of the homology and opposite orientation of RHD and RHCE, numerous gene rearrangements have occurred in Africans and resulted in altered RH alleles that predict partial antigens, contributing to the high rate of Rh alloimmunisation among patients with sickle cell disease (SCD). In this study, we characterised variant RH alleles encoding partial antigens and/or lacking high prevalence antigens in patients with SCD and in African Brazilian donors, in order to support antigen-matched blood for transfusion...
September 2016: Blood Transfusion, Trasfusione del Sangue
Ketevan Keshelashvili, Alix O'meara, Martin Stern, Zuzana Jirout, Vildana Pehlic, Andreas Holbro, Andreas Buser, Jörg Sigle, Laura Infanti
BACKGROUND: Safety of double-erythrocyte (2RBC) collection and reasons for ceasing 2RBC donation were retrospectively analysed in the blood donor population of Basel, Switzerland. METHODS: Donors with at least 1 2RBC apheresis were included in the study. Minimal requirements were Hb ≥140 g/L and body weight ≥70 kg; serum ferritin (SF) values were measured routinely, but were not part of the selection criteria. 2RBC collections were performed with ALYX devices at 6-month intervals...
September 2016: Blood Transfusion, Trasfusione del Sangue
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