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Blood Transfusion, Trasfusione del Sangue

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https://www.readbyqxmd.com/read/28287381/a-preliminary-evaluation-of-next-generation-sequencing-as-a-screening-tool-for-targeted-genotyping-of-erythrocyte-and-platelet-antigens-in-blood-donors
#1
Agnieszka Orzińska, Katarzyna Guz, Michał Mikula, Maria Kulecka, Anna Kluska, Aneta Balabas, Monika Pelc-Kłopotowska, Jerzy Ostrowski, Ewa Brojer
BACKGROUND: Matching the compatibility of donor blood with the recipient's antigens prevents alloimmunisation. Next-generation sequencing (NGS) technology is a promising method for extensive blood group and platelet antigen genotyping of blood donors. It circumvents the limitations of detecting known alleles based on predefined polymorphisms and enables targeted sequencing on a massive scale. The aim of this study was to evaluate the NGS AmpliSeq application on the Ion Torrent platform as a screening tool for genotyping blood donors' erythrocyte/platelet antigens...
March 10, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287383/fibrinogen-concentrate-in-surgery
#2
Giuseppe Marano, Carlo Mengoli, Massimo Franchini, Stefania Vaglio, Sara Gentili, Simonetta Pupella, Giancarlo M Liumbruno
No abstract text is available yet for this article.
March 9, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287378/application-of-a-clot-based-assay-to-measure-the-procoagulant-activity-of-stored-allogeneic-red-blood-cell-concentrates
#3
Bérangère Devalet, Adeline Wannez, Nicolas Bailly, Lutfiye Alpan, Damien Gheldof, Jonathan Douxfils, Véronique Deneys, Benoît Bihin, Bernard Chatelain, Jean-Michel Dogné, Christian Chatelain, François Mullier
BACKGROUND: Thrombotic effects are possible complications of red blood cell transfusion. The generation and accumulation of procoagulant red blood cell extracellular vesicles during storage may play an important role in these thrombotic effects. The objective of this study was to assess the value of a simple phospholipid-dependent clot-based assay (STA(®)-Procoag-PPL) to estimate the procoagulant activity of stored red blood cells and changes in this activity during storage of the blood component...
March 9, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287385/interference-of-direct-oral-anticoagulants-in-haemostasis-assays-high-potential-for-diagnostic-false-positives-and-false-negatives
#4
EDITORIAL
Emmanuel J Favaloro, Giuseppe Lippi
No abstract text is available yet for this article.
March 7, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287382/effect-of-dabigatran-on-a-prothrombinase-based-assay-for-detecting-activated-protein-c-resistance-an-ex-vivo-and-in-vitro-study-in-normal-subjects-and-factor-v-leiden-carriers
#5
Gianluca Gessoni, Sara Valverde, Letizia Valle, Pierpaolo Caruso, Francesca Gessoni, Roberto Valle
BACKGROUND: The aim of this study was to evaluate ex vivo and in vitro interference of a direct factor IIa inhibitor, dabigatran, on a prothrombinase-based assay to detect activated protein C resistance. MATERIALS AND METHODS: An ex vivo study was performed in six heterozygous factor V Leiden carriers and 12 normal subjects without the factor V Leiden mutation who were treated with dabigatran. An in vitro study was also performed considering 12 plasma samples (six from normal subjects and six from heterozygous factor V Leiden carriers) spiked with dabigatran...
March 7, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287386/recommendations-for-factor-viii-product-source-to-treat-patients-with-haemophilia-a
#6
LETTER
Romano Arcieri, Gabriele Calizzani, Fabio Candura, Pier Mannuccio Mannucci
No abstract text is available yet for this article.
March 2, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287380/the-increased-demand-for-plasma-derived-factor-viii-in-italy-between-2011-and-2014-is-attributable-to-treatment-of-adult-patients-rather-than-paediatric-or-previously-unexposed-patients-with-severe-haemophilia-a
#7
LETTER
Antonio Coppola, Elena Santagostino, Hamisa J Hassan, Angelo C Molinari, Rita C Santoro, Annarita Tagliaferri, Massimo Morfini, Giovanni Di Minno
No abstract text is available yet for this article.
March 2, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287376/increase-of-plasma-concentration-to-10-improves-a-number-of-in-vitro-storage-parameters-of-apheresis-platelets-suspended-in-a-bicarbonate-containing-additive-solution-and-stored-with-a-24-hour-interruption-of-agitation
#8
Stephen J Wagner, Andrey Skripchenko, Cheryl A Hapip, Nadine Kaelber, Annette Turgeon
BACKGROUND: A previous study demonstrated several pH failures during 7-day storage of platelets suspended in 5% plasma/95% PAS-5 following a 24-hour interruption of agitation. The aim of this study was to investigate whether pH control improves in platelets stored in PAS-5 with 10% plasma following interruption of agitation. MATERIALS AND METHODS: Four aliquots were prepared from a single unit of apheresis platelets: two each with 5% and 10% plasma. After resting for 1 hour, the aliquots were placed on an agitator...
March 2, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287384/effects-of-potassium-adsorption-filters-on-the-removal-of-ammonia-from-blood-products
#9
Hiroshi Fujita, Yoko Shiotani, Yuko Takada, Shigeko Nishimura
BACKGROUND: Although ammonia in plasma does not usually pass through the blood-brain barrier (BBB), in cases of traumatic brain injury it may do so, acting as a neurotoxin on the brain. Excess intake of ammonia should be restricted in conditions involving BBB breakdown, such as traumatic brain injury. Washing is a method to remove ammonia from blood products, but fresh-frozen plasma and albumin products cannot be washed. A potassium adsorption filter (PAF) can remove not only potassium, but also ammonia from red blood cell solutions...
March 1, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287379/k-antigen-blocking-in-a-case-of-haemolytic-disease-of-the-foetus-and-newborn
#10
LETTER
Silvia Manfroi, Claudio Velati
No abstract text is available yet for this article.
February 3, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28287377/use-of-dabigatran-and-rivaroxaban-in-non-valvular-atrial-fibrillation-one-year-follow-up-experience-in-an-italian-centre
#11
Mario Schiavoni, Maurizio Margaglione, Antonella Coluccia
BACKGROUND: Direct oral anticoagulants (DOAC) have been shown to be non-inferior to traditional vitamin K antagonists in preventing stroke and arterial thromboembolism in patients with non-valvular atrial fibrillation. Nevertheless, it is mandatory to record side effects and individual adherence to DOAC treatment. MATERIALS AND METHODS: In this single-centre experience, patients with non-valvular atrial fibrillation were prospectively observed after switching from a vitamin K antagonist to dabigatran or rivaroxaban...
January 31, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28151395/molecular-basis-of-the-duffy-blood-group-system
#12
REVIEW
Gabriela Höher, Marilu Fiegenbaum, Silvana Almeida
ACKR1, located on chromosome 1q23.2, is the gene that encodes a glycoprotein expressing the Duffy blood group antigens. This gene is transcribed in two mRNA variants yielding two isoforms, encoding proteins with 338 and 336 amino acids. This review provides a general overview of the Duffy blood group to characterise and elucidate the genetic basis of this system. The Fy(a) and Fy(b) antigens are encoded by co-dominant FY*A (FY*01) and FY*B (FY*02) alleles, which differ by c.125G>A (rs12075), defining the Fy(a+b-), Fy(a-b+) and Fy(a+b+) phenotypes...
January 30, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28263179/interpreting-the-deluge-of-omics-data-new-approaches-offer-new-possibilities
#13
LETTER
Aarash Bordbar
No abstract text is available yet for this article.
March 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28263178/the-3-phase-evolution-of-stored-red-blood-cells-and-the-clinical-trials-an-obvious-relationship
#14
LETTER
Michel Prudent, Jean-Daniel Tissot, Niels Lion
No abstract text is available yet for this article.
March 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28263177/red-blood-cell-proteomics-update-is-there-more-to-discover
#15
Angelo D'alessandro, Monika Dzieciatkowska, Travis Nemkov, Kirk C Hansen
No abstract text is available yet for this article.
March 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28263176/enhancing-uniformity-and-overall-quality-of-red-cell-concentrate-with-anaerobic-storage
#16
Tatsuro Yoshida, Abbejane Blair, Angelo D'alessandro, Travis Nemkov, Michael Dioguardi, Christopher C Silliman, Andrew Dunham
BACKGROUND: Recent research focused on understanding stored red blood cell (RBC) quality has demonstrated high variability in measures of RBC function and health across units. Studies have historically linked this high variability to variations in processing, storage method, and age. More recently, a large number of studies have focused on differences in donor demographics, donor iron sufficiency, and genetic predisposition of the donor to poor storage, particularly through mechanisms of accelerated oxidative damage...
March 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28263175/the-purified-vepoloxamer-prevents-haemolysis-in-42-day-stored-dehp-pvc-free-red-blood-cell-units
#17
Jose A Cancelas, Neeta Rugg, Shawnagay Nestheide, Sarah E Hill, R Martin Emanuele, Douglas S Mckenzie
BACKGROUND: Use of the plasticiser di(2-ethylhexyl) phthalate (DEHP) in polyvinyl chloride (PVC) blood bags poses a potential dilemma. The presence of DEHP in blood bags has been shown to be beneficial to red blood cells during storage by diminishing haemolysis. However, DEHP use in PVC may be carcinogenic or estrogenising. Vepoloxamer is a poloxamer with rheological and cytoprotective rheological properties and a favourable toxicity profile in clinical trials. We hypothesised that vepoloxamer may be sufficient to replace the plasticiser DEHP to prevent elevated haemolysis while conserving the biochemical and redox potential++ in RBCs stored for up to 42 days...
March 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28263174/iron-deficient-erythropoiesis-in-blood-donors-and-red-blood-cell-recovery-after-transfusion-initial-studies-with-a-mouse-model
#18
Sheila Bandyopadhyay, Gary M Brittenham, Richard O Francis, James C Zimring, Eldad A Hod, Steven L Spitalnik
BACKGROUND: Most frequent red cell (RBC) donors and many first-time donors are iron deficient, but meet haemoglobin standards. However, the effects of donation-induced iron deficiency on RBC storage quality are unknown. Thus, we used a mouse model to determine if donor iron deficiency reduced post-transfusion RBC recovery. METHODS: Weanling mice received a control diet or an iron-deficient diet. A third group receiving the iron-deficient diet was also phlebotomised weekly...
March 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28263173/modelling-the-effects-of-blood-component-storage-lesions-on-the-quality-of-haemostatic-resuscitation-in-massive-transfusion-for-trauma
#19
REVIEW
James A Mays, John R Hess
BACKGROUND: All blood components undergo loss of potency during storage. These loss-of-potency storage lesions are important in trauma resuscitation because they reduce the haemostatic capacity of mixtures of components that attempt to reconstitute whole blood. Even red cell storage-related loss of potency, which averages 17% with modern additive solutions, is important because 6 units of red cells must be given to achieve the effect of 5 fully potent units. MATERIALS AND METHODS: Loss of potency of stored units of red blood cells, plasma, platelets, and cryoprecipitate were summed for dilutional, storage-related, pathogen reduction-related, and splenic sequestration-related causes and expressed as fractional plasma coagulation factor concentrations and platelet counts...
March 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28263172/duration-of-red-blood-cell-storage-and-inflammatory-marker-generation
#20
REVIEW
Caroline Sut, Sofiane Tariket, Ming Li Chou, Olivier Garraud, Sandrine Laradi, Hind Hamzeh-Cognasse, Jerard Seghatchian, Thierry Burnouf, Fabrice Cognasse
Red blood cell (RBC) transfusion is a life-saving treatment for several pathologies. RBCs for transfusion are stored refrigerated in a preservative solution, which extends their shelf-life for up to 42 days. During storage, the RBCs endure abundant physicochemical changes, named RBC storage lesions, which affect the overall quality standard, the functional integrity and in vivo survival of the transfused RBCs. Some of the changes occurring in the early stages of the storage period (for approximately two weeks) are reversible but become irreversible later on as the storage is extended...
March 2017: Blood Transfusion, Trasfusione del Sangue
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