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Journal of Zhejiang University. Science. B

Yuan-Qiang Lu
Though the cases of HIV patients with paraquat (PQ) poisoning are rare, we still found the common features. These recovered HIV patients tended to result in much less lung injury, and had low CD4+ T lymphocyte levels due to HIV infection, which meant they were under the immunosuppressive condition during treatment. This may be conducive to relieve the acute inflammation and lung fibrosis induced by PQ. Thus, we consider the immunosuppressive therapy for PQ poisoning to be appropriate. However, the drugs used currently may be not optimal for toxic patient...
2018: Journal of Zhejiang University. Science. B
Yi-Ying Zhao, Qiang Chu, Xu-Er Shi, Xiao-Dong Zheng, Xiao-Ting Shen, Yan-Zhen Zhang
To address the controversial issue of the toxicity of dental alloys and silver nanoparticles in medical applications, an in vivo-like LO2 3-D model was constructed within polyvinylidene fluoride hollow fiber materials to mimic the microenvironment of liver tissue. The use of microscopy methods and the measurement of liver-specific functions optimized the model for best cell performances and also proved the superiority of the 3-D LO2 model when compared with the traditional monolayer model. Toxicity tests were conducted using the newly constructed model, finding that four dental castings coated with silver nanoparticles were toxic to human hepatocytes after cell viability assays...
2018: Journal of Zhejiang University. Science. B
Lin Tang, Wei-Jun Luo, Zhen-Li He, Hanumanth Kumar Gurajala, Yasir Hamid, Kiran Yasmin Khan, Xiao-E Yang
Vegetables are important constituents of the human diet. Heavy metals and nitrate are among the major contaminants of vegetables. Consumption of vegetables and fruits with accumulated heavy metals and nitrate has the potential to damage different body organs leading to unwanted effects. Breeding vegetables with low heavy metal and nitrate contaminants is a cost-effective approach. We investigated 38 water spinach genotypes for low Cd and nitrate co-accumulation. Four genotypes, i.e. JXDY, GZQL, XGDB, and B888, were found to have low co-accumulation of Cd (<0...
2018: Journal of Zhejiang University. Science. B
Essa Ali, Nazim Hussain, Imran Haider Shamsi, Zahra Jabeen, Muzammil Hussain Siddiqui, Li-Xi Jiang
The well-known detrimental effects of cadmium (Cd) on plants are chloroplast destruction, photosynthetic pigment inhibition, imbalance of essential plant nutrients, and membrane damage. Jasmonic acid (JA) is an alleviator against different stresses such as salinity and drought. However, the functional attributes of JA in plants such as the interactive effects of JA application and Cd on rapeseed in response to heavy metal stress remain unclear. JA at 50 µmol/L was observed in literature to have senescence effects in plants...
2018: Journal of Zhejiang University. Science. B
Abdul Wahab, Syed Aleem Jan, Abdur Rauf, Zia Ur Rehman, Zahid Khan, Aftab Ahmed, Fatima Syed, Sher Zaman Safi, Hamayun Khan, Muhammad Imran
OBJECTIVE: Scandix pecten-veneris L. is a less studied wild edible herb and is considered an extinct plant species in many parts of the world. This study was designed to evaluate its phytochemical composition and biological potential of S. pecten-veneris L. METHODS: Phytochemicals including alkaloids, flavonoids, polyphenols, and tannins were determined in extracts of S. pecten-veneris. Antioxidant activity was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), while reducing power was tested by ferric reducing/antioxidant power (FRAP) assay...
2018: Journal of Zhejiang University. Science. B
Xavier-Ravi Baskaran, Antony-Varuvel Geo Vigila, Shou-Zhou Zhang, Shi-Xiu Feng, Wen-Bo Liao
The aim of this review was to explore the pharmacological activity of early tracheophytes (pteridophytes) as an alternative medicine for treating human ailments. As the first vascular plants, pteridophytes (aka, ferns and fern allies) are an ancient lineage, and human beings have been exploring and using taxa from this lineage for over 2000 years because of their beneficial properties. We have documented the medicinal uses of pteridophytes belonging to thirty different families. The lycophyte Selaginella sp...
2018: Journal of Zhejiang University. Science. B
Lu-Yao Huang, Min Wu, Xiao-Yun Yu, Lin Li, Fu-Cheng Lin, Xiao-Hong Liu
In this study, we analyzed the physical interactions of the dominant negative isoform of MoYpt7. Our results show that MoYpt7 interacts with MoGdi1. The dominant negative isoform of MoYpt7 (dominant negative isoform, N125I) is essential for colony morphology, conidiation, and pathogenicity in the rice blast fungus. These results further demonstrate the biological functions of MoYpt7 in Magnaporthe oryzae.
2018: Journal of Zhejiang University. Science. B
Peng-Fei Qu, Ya Zhang, Jia-Mei Li, Ruo Zhang, Jiao-Mei Yang, Fang-Liang Lei, Shan-Shan Li, Dan-Meng Liu, Shao-Nong Dang, Hong Yan
OBJECTIVE: This study investigated complementary feeding practices among four ethnic groups (Han, Uygur, Tibetan, and Zhuang) based on a cross-sectional survey in rural western China. METHODS: In 2005, a stratified multistage cluster random sampling method was used to recruit 9712 children (7411 Han, 1032 Uygur, 678 Tibetan, and 591 Zhuang) between 6 and 35 months of age and their mothers from 45 counties in 10 provinces (autonomous regions, municipalities) in western China...
2018: Journal of Zhejiang University. Science. B
Wojciech Szczęsny, Magdalena Kuligowska-Prusińska, Stanisław Dąbrowiecki, Jakub Szmytkowski, Adrian Reśliński, Maciej Słupski
PURPOSE: Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2 (MMP-2), MMP-9, MMP-13, and adiponectin in morbidly obese and non-overweight controls. MATERIALS AND METHODS: The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups: I (body mass index (BMI)≥35 kg/m2, n=40) and II (BMI<25 kg/m2, n=30)...
2018: Journal of Zhejiang University. Science. B
Sanjay Jaiswal, Xian-Bao Liu, Qu-Cheng Wei, Ying-Hao Sun, Li-Han Wang, Liu-Guang Song, Dan-Dan Yang, Jian-An Wang
OBJECTIVE: The purpose of this meta-analysis was to explore the effect of corticosteroids on atrial fibrillation (AF) following catheter ablation. METHODS: We searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials for published articles describing the effect of corticosteroids in preventing AF recurrence after catheter ablation. Data on study and patient were extracted. Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated by use of a random-effect model, and P values of <0...
2018: Journal of Zhejiang University. Science. B
Yuan Gao, Ling Xia, Ying-Lan Gong, Ding-Chang Zheng
Left anterior fascicular block (LAFB) is a heart disease identifiable from an abnormal electrocardiogram (ECG). It has been reported that LAFB is associated with an increased risk of heart failure. Non-specific intraventricular conduction delay due to the lesions of the conduction bundles and slow cell to cell conduction has also been considered as another cause of heart failure. Since the location and mechanism of conduction delay have notable variability between individual patients, we hypothesized that the impaired conduction in the ventricular myocardium may lead to abnormal ECGs similar to LAFB ECG patterns...
2018: Journal of Zhejiang University. Science. B
Yun-Feng Liu, Russell Wang, Dale A Baur, Xian-Feng Jiang
OBJECTIVE: To investigate the stress distribution to the mandible, with and without impacted third molars (IM3s) at various orientations, resulting from a 2000-Newton impact force either from the anterior midline or from the body of the mandible. MATERIALS AND METHODS: A 3D mandibular virtual model from a healthy dentate patient was created and the mechanical properties of the mandible were categorized to 9 levels based on the Hounsfield unit measured from computed tomography (CT) images...
2018: Journal of Zhejiang University. Science. B
Jun Meng, Wen-Yuan Xu, Xiao Chen, Tao Lin, Xiao-Yu Deng
We propose that locations of genes on chromosomes can contribute to the prediction of gene regulatory relationships. We constructed a time-based gene regulatory network of zebrafish cardiogenesis on the basis of a spatio-temporal neighborhood method. Through the network, specific regulatory pathways and order of gene expression during zebrafish cardiogenesis were obtained. By comparing the order with locations of these genes on chromosomes, we discovered that there exists a reversal phenomenon between the order and order of gene locations...
2018: Journal of Zhejiang University. Science. B
U Rajendra Acharya, Yuki Hagiwara, Vidya K Sudarshan, Wai Yee Chan, Kwan Hoong Ng
Radiology (imaging) and imaging-guided interventions, which provide multi-parametric morphologic and functional information, are playing an increasingly significant role in precision medicine. Radiologists are trained to understand the imaging phenotypes, transcribe those observations (phenotypes) to correlate with underlying diseases and to characterize the images. However, in order to understand and characterize the molecular phenotype (to obtain genomic information) of solid heterogeneous tumours, the advanced sequencing of those tissues using biopsy is required...
2018: Journal of Zhejiang University. Science. B
Xiao-Jun Hu, Jian-Hong Luo, Ronald Rousseau
Publication citation-based research evaluation, even if only in support of peer review, is not everywhere, on every level, or for everyone suitable, because of differences in scientific research, patterns of research output, stages of scientific evolution, and merits-scientific or societal-of scientific results.
2018: Journal of Zhejiang University. Science. B
Yuan Liang, Zhou Yang, Zi-Gang Xu, Lin Ma
In this study, we describe a 2-year-old boy patient with nephroblastoma who has developed toxic epidermal necrolysis (TEN) associated with the combination chemotherapy administration of dactinomycin and vincristine. A skin biopsy confirmed the diagnosis of TEN, and with methylprednisolone pulse therapy, intravenous immunoglobulin (IVIG), and supportive care, the patient improved significantly.
July 2017: Journal of Zhejiang University. Science. B
Tao Lu, Jie-Wei Shi, Zhou-Ping Sun, Ming-Fang Qi, Yu-Feng Liu, Tian-Lai Li
OBJECTIVE: To evaluate the possible photoprotection mechanisms of cyclic and linear electron flux (CEF and LEF) under specific high temperature and high light (HH) stress. METHODS: Six-leaf-stage tomato seedlings ("Liaoyuanduoli", n=160) were divided into four parts: Part 1, served as control under 25 °C, 500 µmol/(m(2)·s); Part 2, spayed with distilled water (H2O) under 35 °C, 1000 µmol/(m(2)·s) (HH); Part 3, spayed with 100 µmol/L diuron (DCMU, CEF inhibitor) under HH; Part 4, spayed with 60 µmol/L methyl viologen (MV, LEF inhibitor) under HH...
July 2017: Journal of Zhejiang University. Science. B
Ai-Ling Zhang, Xian-Yue Sun, Qi Yin, Jian-Hua Zeng, Zhe Zhang, Jia-Qi Li, Hao Zhang
Prostaglandins (PGs) play a critical role in porcine reproduction, of which prostaglandin E2 (PGE2) and prostaglandin F2α (PGF2α) exert antiluteolytic and luteolysis actions, respectively. As a rate-limiting enzyme, carbonyl reductase 1 (CBR1) catalyzes the conversion of PGE2 to PGF2α. A high ratio of PGE2:PGF2α is beneficial to the establishment and maintenance of porcine pregnancy. PG is essential for the establishment of pregnancy which resembles the proinflammatory response and nuclear factor κB (NF-κB) is involved in the process...
July 2017: Journal of Zhejiang University. Science. B
Xiao-Ting Shen, Yan-Zhen Zhang, Fang Xiao, Jing Zhu, Xiao-Dong Zheng
The aim of this study was to research the changes in cytotoxicity and antibacterial properties after silver nanoparticles (AgNPs) were incorporated into the surface coating of dental alloys. AgNPs were attached to cobalt chromium alloys and pure titanium using a hydrothermal method, according to the reaction: AgNO3+NaBH4→ Ag+1/2H2+1/2B2H6+NaNO3. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was used to evaluate the cytotoxicity of the alloys when in contact with osteogenic precursor cells (MC3T3-E1) from mice and mesenchymal stem cells (BMSC) from rats...
July 2017: Journal of Zhejiang University. Science. B
Si-Gong Zhang, Yu-Xin Song, Xiao-Ming Shu, Hai-Li Shen, Han-Bo Yang, Rui-Xue Duo, Guo-Chun Wang
OBJECTIVE: Low-density granulocytes (LDGs) can form neutrophil extracellular traps (NETs) spontaneously and excessively. When peripheral blood mononuclear cells (PBMCs) are used for studying T lymphocytes, LDGs contained in the PBMCs may decrease the threshold of activating T lymphocytes by forming NETs. This study focused on the profiles of LDGs in common autoimmune diseases and methods for removing LDGs from PBMCs. METHODS: The percentages of LDGs in PBMCs from 55 patients with dermatomyositis (DM), 15 with polymyositis (PM), 42 with rheumatoid arthritis (RA), 25 with systemic lupus erythematosus (SLE), and 19 healthy controls were determined by flow cytometry...
July 2017: Journal of Zhejiang University. Science. B
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