Fulong Nan, Wenlong Nan, Xin Yan, Hui Wang, Shasha Jiang, Shuyun Zhang, Zhongjie Yu, Xianjuan Zhang, Fengjun Liu, Jun Li, Xiaoqiong Zhou, Delei Niu, Yiquan Li, Wei Wang, Ning Shi, Ningyi Jin, Changzhan Xie, Xiaoni Cui, He Zhang, Bin Wang, Huijun Lu
As a potential vectored vaccine, Newcastle disease virus (NDV) has been subject to various studies for vaccine development, while relatively little research has outlined the immunomodulatory effect of the virus in antigen presentation. To elucidate the key inhibitory factor in regulating the interaction of infected dendritic cells (DCs) and T cells, DCs were pretreated with the NDV vaccine strain LaSota as an inhibitor and stimulated with lipopolysaccharide (LPS) for further detection by enzyme-linked immunosorbent assay (ELISA), flow cytometry, immunoblotting, and quantitative real-time polymerase chain reaction (qRT-PCR)...
March 15, 2024: Journal of Zhejiang University. Science. B