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Annals of General Psychiatry

Kelelemua Haile, Tadesse Awoke, Getinet Ayano, Minale Tareke, Andargie Abate, Mulugeta Nega
[This corrects the article DOI: 10.1186/s12991-018-0174-6.].
2018: Annals of General Psychiatry
Pauline W Ng'ang'a, Muthoni Mathai, Anne Obondo, Teresia Mutavi, Manasi Kumar
Background: Psychiatric morbidity is commonly associated with HIV disease and may have adverse effects. This aspect may be overlooked at comprehensive HIV care centers in Low and Middle-Income Countries. Objectives: The aim of this study was to determine the prevalence of undetected psychiatric morbidity among HIV/AIDS adult patients attending Comprehensive Care Centre in a semi-urban clinic, in Nairobi, Kenya. Design: Descriptive cross-sectional study of adult HIV patients not receiving any psychiatric treatment was conducted...
2018: Annals of General Psychiatry
Sophee Blanthorn-Hazell, Alfredo Gracia, Jenna Roberts, Anca Boldeanu, Davneet Judge
Background: Agitation is a common feature of bipolar disorder and schizophrenia. Previous research indicates that specific symptoms impact caregiver burden in these conditions, but the impact of agitation on caregiver experience is poorly understood. The aim of this study was to characterise caregiver burden in providers of informal care for patients with bipolar disorder and schizophrenia who experience agitation. Methods: In total, 297 matched patient and caregiver surveys were collected across the UK, Germany and Spain between October 2016 and January 2017...
2018: Annals of General Psychiatry
Caroline Lücke, Jürgen M Gschossmann, Teja W Grömer, Sebastian Moeller, Charlotte E Schneider, Aikaterini Zikidi, Alexandra Philipsen, Helge H O Müller
Background: Off-label prescribing of psychoactive drugs is a common practice in psychiatry. Here, we sought to investigate the frequency of off-label prescribing in a population of hospitalized patients with a somatic illness who were also suffering from a psychiatric pathology. Methods: Using a prospective, observational design, we collected data from 982 hospitalized patients with a somatic illness for whom a psychiatric consultation was requested because of the presence of additional psychiatric symptoms...
2018: Annals of General Psychiatry
Nana Xiong, Jing Wei, Kurt Fritzsche, Rainer Leonhart, Xia Hong, Tao Li, Jing Jiang, Liming Zhu, Guoqing Tian, Xudong Zhao, Lan Zhang, Rainer Schaefert
[This corrects the article DOI: 10.1186/s12991-017-0158-y.].
2018: Annals of General Psychiatry
Hiroko Kashiwagi, Akiko Kikuchi, Mayuko Koyama, Daisuke Saito, Naotsugu Hirabayashi
Background: The Structured Assessment of PROtective Factors for violence risk (SAPROF) was recently developed as a strength-based addition to the risk assessment of future violent behavior. We examined the interrater reliability and predictive accuracy of the SAPROF for violence in forensic mental health inpatient units in Japan. Methods: This retrospective record study provides an initial validation of the SAPROF in a Japanese sample of 95 forensic psychiatric inpatients from a complete 2008-2013 cohort...
2018: Annals of General Psychiatry
Kelelemua Haile, Tadesse Awoke, Getnet Ayano, Minale Tareke, Andargie Abate, Mulugeta Nega
Background: Suicidal ideation and attempts are more frequent in people with epilepsy than in general population and suicide attempt increases the chance of later completed suicide. The aim of this study was to assess the prevalence and associated factors of suicidal ideation and attempt among people with epilepsy in Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia. Methods: Institution-based cross-sectional study was conducted from May to June 2014 at Amanuel Mental Specialized Hospital among people with epilepsy...
2018: Annals of General Psychiatry
Angelo G I Maremmani, Denise Gazzarrini, Amelia Fiorin, Valeria Cingano, Graziano Bellio, Giulio Perugi, Icro Maremmani
Background: In the Gambling Disorder (GD), there is no exogenous drug administration that acts as the central core of the traditional meaning of addiction. A specific psychopathology of Substance Use Disorders has been proposed recently. In a sample of Heroin Use Disorder (HUD) patients entering opioid agonist treatment, it became possible to identify a group of 5 mutually exclusive psychiatric dimensions: Worthlessness-Being trapped (W-BT), Somatic Symptoms (SS), Sensitivity-Psychoticism (SP), Panic Anxiety (PA) and Violence-Suicide (VS)...
2018: Annals of General Psychiatry
Congjie Wang, Wenjie Shi, Chengbing Huang, Jiannan Zhu, Wenzhong Huang, Gang Chen
Background: Differences in effectiveness and tolerability between different atypical antipsychotics may affect schizophrenic patients' treatment adherence or prognosis. However, which kind of antipsychotic was more effective and safe in the treatment of schizophrenia is still being debated. This study attempted to understand whether there are any differences in efficacy, acceptability, and safety between the five atypical antipsychotics in patients with first-episode schizophrenia. Methods: Two hundred cases of inpatients with first-episode drug-naïve schizophrenia were randomly assigned to 6-8 weeks of treatment with either of aripiprazole, risperidone, quetiapine, olanzapine, or ziprasidone from October 2012 to November 2014...
2017: Annals of General Psychiatry
Yen-Cheng Ho, Huang-Li Lin
Background: Clozapine-induced eosinophilia had been reported in several studies about blood dyscrasias in clozapine-treated patient. The largest study with 2404 patients in Italy found the incidence of 2.2% by criteria of more than 0.4 × 109 /l. Associated cases of pancreatitis, hepatitis, colitis, nephritis, and myocarditis were reported. Interestingly, incidence of myocarditis is high in Australia, but low in the rest of the world. In the following, we will present a case of clozapine-induced eosinophilia which spontaneous resolution was noted under continuation of clozapine...
2017: Annals of General Psychiatry
Soo-Hyun Paik, Mi Ran Choi, Su Min Kwak, Sol Hee Bang, Ji-Won Chun, Jin-Young Kim, Jihye Choi, Hyun Cho, Jo-Eun Jeong, Dai-Jin Kim
Background: Though Internet gaming disorder (IGD) is considered to share similar genetic vulnerability with substance addictions, little has been explored about the role of the genetic variants on IGD. This pilot study was designed to investigate the association of the Taq1A polymorphism of the ankyrin repeat and kinase domain containing 1 ( ANKK1 ) gene and C957T and -  141C of the dopamine D2 receptor ( DRD2 ) with IGD and their role on the personality and temperament traits in IGD among adult population...
2017: Annals of General Psychiatry
Shengnan Wei, Haiyan Li, Jinglin Hou, Wei Chen, Xu Chen, Xiaoxia Qin
Background: Major depressive disorder (MDD) is a known major risk factor for suicide due to the high suicide mortality. However, studies comparing the characteristics of suicide attempters with major depressive disorder and those with no psychiatric diagnosis in China are very limited. This study examined and compared the sociodemographic and psychological characteristics of suicide attempters with MDD and those with no psychiatric diagnosis in emergency departments of general hospitals to better understand the risk factors for suicide attempts in China...
2017: Annals of General Psychiatry
Eiji Kirino
Objectives: Antipsychotics, even atypical ones, can induce hyperprolactinemia. Aripiprazole (APZ), a dopamine D2 partial agonist, has a unique pharmacological profile and few side effects. We investigated the incidence of hyperprolactinemia in patients with schizophrenia treated with APZ and other antipsychotics. Methods: Serum prolactin levels were measured by ELISA (enzyme-linked immunosorbent assay). A questionnaire survey was used to evaluate subjective sexual dysfunction...
2017: Annals of General Psychiatry
Vasilis Stavropoulos, Kathleen A Moore, Helen Lazaratou, Dimitris Dikaios, Rapson Gomez
The severity of obsessive compulsive symptoms (OCS) is suggested to be normally distributed in the general population, and they appear to have an impact on a range of aspects of adolescent development. Importantly, there are individual differences regarding susceptibility to OCS. In the present repeated measures study, OCS were studied in relation to gender and emotional stability (as a personality trait) using a normative sample of 515 adolescents at ages 16 and 18 years. OCS were assessed with the relevant subscale of the SCL-90-R and emotional stability with the Five Factor Questionnaire...
2017: Annals of General Psychiatry
Najiba Fekih-Mrissa, Ines Bedoui, Aycha Sayeh, Hajer Derbali, Meriem Mrad, Ridha Mrissa, Brahim Nsiri
Background: The angiotensin-converting enzyme gene (ACE) insertion/deletion (I/D or indel) polymorphism has long been linked to Alzheimer's disease (AD), but the interpretation of established data remains controversial. The aim of this study was to determine whether the angiotensin-converting enzyme is associated with the risk of Alzheimer's disease in Tunisian patients. Methods: We analyzed the genotype and allele frequency distribution of the ACE I/D gene polymorphism in 60 Tunisian AD patients and 120 healthy controls...
2017: Annals of General Psychiatry
Getinet Ayano, Dawit Assefa, Kibrom Haile, Asrat Chaka, Haddish Solomon, Petros Hagos, Zegeye Yohannis, Kelemua Haile, Lulu Bekana, Melkamu Agidew, Seife Demise, Belachew Tsegaye, Melat Solomon
Background: About 25-60% of the homeless population is reported to have some form of mental disorder. To our knowledge, there are no studies aimed at the screening, diagnosis, treatment, care, rehabilitation, and support of homeless people with mental, neurologic, and substance use (MNS) disorders in general in Ethiopia. This is the first study of its kind in Africa which was aimed at screening, diagnosis, care, treatment, rehabilitation, and support of homeless individuals with possible MNS disorder...
2017: Annals of General Psychiatry
Mina Poorrezaeian, Fereydoun Siassi, Alireza Milajerdi, Mostafa Qorbani, Javad Karimi, Reza Sohrabi-Kabi, Neda Pak, Gity Sotoudeh
Background: Substantial evidence provides support for the role of diet in the prevention and control of mental disorders. However, since there is no study regarding the relationship between dietary diversity and stress or depression, we aimed to determine the relationship between the dietary diversity score (DDS) and stress and depression in women. Methods: This descriptive-analytical cross-sectional study was performed on 360 women aged 20-49 years attending health centers in the south of Tehran...
2017: Annals of General Psychiatry
Oleg A Levada, Alexandra S Troyan
Depression and cognitive dysfunction share a common neuropathological platform. Abnormal neural plasticity in the frontolimbic circuits has been linked to changes in the expression of neurotrophic factors, including IGF-1. These changes may result in clinical abnormalities observed over the course of major depressive disorder (MDD), including cognitive dysfunction. The present review aimed to summarize evidence regarding abnormalities of peripheral IGF-1 in MDD patients and assess a marker and predictive role of the neurotrophin for emotional and cognitive disturbances, and treatment effectiveness...
2017: Annals of General Psychiatry
Sachiko Kozasa, Arata Oiji, Akio Kiyota, Tetsuji Sawa, Soo-Yung Kim
BACKGROUND: Several studies have proven that the experiences of being bullied or bullying others are associated with poor mental health among adolescent youths. Our study aims to investigate the relationship between the experience of the bully/victim and mental health among preadolescents and adolescents. METHODS: Subjects were the Japanese fifth and sixth grade elementary school students (preadolescents: mean age = 11.3 years; n = 338) and junior high school students (adolescents: mean age = 13...
2017: Annals of General Psychiatry
Jonathan M Meyer, Daisy S Ng-Mak, Chien-Chia Chuang, Krithika Rajagopalan, Antony Loebel
BACKGROUND: Severe and persistent mental illnesses, such as schizophrenia and bipolar disorder, are associated with increased risk of obesity compared to the general population. While the association of lurasidone and lower risk of weight gain has been established in short and longer-term clinical trial settings, information about lurasidone's association with weight gain in usual clinical care is limited. This analysis of usual clinical care evaluated weight changes associated with lurasidone treatment in patients with schizophrenia or bipolar disorder...
2017: Annals of General Psychiatry
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