journal
https://read.qxmd.com/read/38509617/in-vitro-inflammation-and-toxicity-assessment-of-pre-and-post-incinerated-organomodified-nanoclays-to-macrophages-using-high-throughput-screening-approaches
#1
JOURNAL ARTICLE
Todd A Stueckle, Jake Jensen, Jayme P Coyle, Raymond Derk, Alixandra Wagner, Cerasela Zoica Dinu, Tiffany G Kornberg, Sherri A Friend, Alan Dozier, Sushant Agarwal, Rakesh K Gupta, Liying W Rojanasakul
BACKGROUND: Organomodified nanoclays (ONC), two-dimensional montmorillonite with organic coatings, are increasingly used to improve nanocomposite properties. However, little is known about pulmonary health risks along the nanoclay life cycle even with increased evidence of airborne particulate exposures in occupational environments. Recently, oropharyngeal aspiration exposure to pre- and post-incinerated ONC in mice caused low grade, persistent lung inflammation with a pro-fibrotic signaling response with unknown mode(s) of action...
March 21, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38468337/epithelial-mapk-signaling-directs-endothelial-nrf2-signaling-and-il-8-secretion-in-a-tri-culture-model-of-the-alveolar-microvascular-interface-following-diesel-exhaust-particulate-dep-exposure
#2
JOURNAL ARTICLE
Eva C M Vitucci, Alysha E Simmons, Elizabeth M Martin, Shaun D McCullough
BACKGROUND: Particulate matter 2.5 (PM2.5 ) deposition in the lung's alveolar capillary region (ACR) is significantly associated with respiratory disease development, yet the molecular mechanisms are not completely understood. Adverse responses that promote respiratory disease development involve orchestrated, intercellular signaling between multiple cell types within the ACR. We investigated the molecular mechanisms elicited in response to PM2.5 deposition in the ACR, in an in vitro model that enables intercellular communication between multiple resident cell types of the ACR...
March 11, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38459567/monitoring-redox-stress-in-human-airway-epithelial-cells-exposed-to-woodsmoke-at-an-air-liquid-interface
#3
JOURNAL ARTICLE
Aiman Abzhanova, Jon Berntsen, Edward R Pennington, Lisa Dailey, Syed Masood, Ingrid George, Nina Warren, Joseph Martin, Michael D Hays, Andrew J Ghio, Jason P Weinstein, Yong Ho Kim, Earl Puckett, James M Samet
Wildland fires contribute significantly to the ambient air pollution burden worldwide, causing a range of adverse health effects in exposed populations. The toxicity of woodsmoke, a complex mixture of gases, volatile organic compounds, and particulate matter, is commonly studied in vitro using isolated exposures of conventionally cultured lung cells to either resuspended particulate matter or organic solvent extracts of smoke, leading to incomplete toxicity evaluations. This study aimed to improve our understanding of the effects of woodsmoke inhalation by building an advanced in vitro exposure system that emulates human exposure of the airway epithelium...
March 8, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38454505/macrophage-derived-exosomal-hmgb3-regulates-silica-induced-pulmonary-inflammation-by-promoting-m1-macrophage-polarization-and-recruitment
#4
JOURNAL ARTICLE
Xiaofeng Qin, Zhiyuan Niu, Hui Chen, Yongbin Hu
BACKGROUND: Chronic inflammation and fibrosis are characteristics of silicosis, and the inflammatory mediators involved in silicosis have not been fully elucidated. Recently, macrophage-derived exosomes have been reported to be inflammatory modulators, but their role in silicosis has not been explored. The purpose of the present study was to investigate the role of macrophage-derived exosomal high mobility group box 3 (HMGB3) in silica-induced pulmonary inflammation. METHODS: The induction of the inflammatory response and the recruitment of monocytes/macrophages were evaluated by immunofluorescence, flow cytometry and transwell assays...
March 7, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38454452/exposure-to-high-dose-of-polystyrene-nanoplastics-causes-trophoblast-cell-apoptosis-and-induces-miscarriage
#5
JOURNAL ARTICLE
Shukun Wan, Xiaoqing Wang, Weina Chen, Manli Wang, Jingsong Zhao, Zhongyan Xu, Rong Wang, Chenyang Mi, Zhaodian Zheng, Huidong Zhang
BACKGROUND: With rapid increase in the global use of various plastics, microplastics (MPs) and nanoplastics (NPs) pollution and their adverse health effects have attracted global attention. MPs have been detected out in human body and both MPs and NPs showed female reproductive toxicological effects in animal models. Miscarriage (abnormal early embryo loss), accounting for 15-25% pregnant women worldwide, greatly harms human reproduction. However, the adverse effects of NPs on miscarriage have never been explored...
March 7, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38448937/correction-perinatal-foodborne-titanium-dioxide-exposure-mediated-dysbiosis-predisposes-mice-to-develop-colitis-through-life
#6
Caroline Carlé, Delphine Boucher, Luisa Morelli, Camille Larue, Ekaterina Ovtchinnikova, Louise Battut, Kawthar Boumessid, Melvin Airaud, Muriel Quaranta-Nicaise, Jean-Luc Ravanat, Gilles Dietrich, Sandrine Menard, Gérard Eberl, Nicolas Barnich, Emmanuel Mas, Marie Carriere, Ziad Al Nabhani, Frédérick Barreau
No abstract text is available yet for this article.
March 6, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38429797/results-from-omic-approaches-in-rat-or-mouse-models-exposed-to-inhaled-crystalline-silica-a-systematic-review
#7
REVIEW
Laura Morin, Valérie Lecureur, Alain Lescoat
BACKGROUND: Crystalline silica (cSiO2 ) is a mineral found in rocks; workers from the construction or denim industries are particularly exposed to cSiO2 through inhalation. cSiO2 inhalation increases the risk of silicosis and systemic autoimmune diseases. Inhaled cSiO2 microparticles can reach the alveoli where they induce inflammation, cell death, auto-immunity and fibrosis but the specific molecular pathways involved in these cSiO2 effects remain unclear. This systematic review aims to provide a comprehensive state of the art on omic approaches and exposure models used to study the effects of inhaled cSiO2 in mice and rats and to highlight key results from omic data in rodents also validated in human...
March 1, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38419076/zinc-oxide-nanoparticles-exacerbate-skin-epithelial-cell-damage-by-upregulating-pro-inflammatory-cytokines-and-exosome-secretion-in-m1-macrophages-following-uvb-irradiation-induced-skin-injury
#8
JOURNAL ARTICLE
Bour-Jr Wang, Yu-Ying Chen, Hui-Hsuan Chang, Rong-Jane Chen, Ying-Jan Wang, Yu-Hsuan Lee
BACKGROUND: Zinc oxide nanoparticles (ZnONPs) are common materials used in skin-related cosmetics and sunscreen products due to their whitening and strong UV light absorption properties. Although the protective effects of ZnONPs against UV light in intact skin have been well demonstrated, the effects of using ZnONPs on damaged or sunburned skin are still unclear. In this study, we aimed to reveal the detailed underlying mechanisms related to keratinocytes and macrophages exposed to UVB and ZnONPs...
February 28, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38409078/differential-pulmonary-toxicity-and-autoantibody-formation-in-genetically-distinct-mouse-strains-following-combined-exposure-to-silica-and-diesel-exhaust-particles
#9
JOURNAL ARTICLE
Lisa Mf Janssen, Frauke Lemaire, Nora Fopke Marain, Steven Ronsmans, Natasja Heylen, Arno Vanstapel, Greetje Vande Velde, Jeroen Aj Vanoirbeek, Kenneth Michael Pollard, Manosij Ghosh, Peter Hm Hoet
BACKGROUND: Inhalation of airborne particulate matter, such as silica and diesel exhaust particles, poses serious long-term respiratory and systemic health risks. Silica exposure can lead to silicosis and systemic autoimmune diseases, while DEP exposure is linked to asthma and cancer. Combined exposure to silica and DEP, common in mining, may have more severe effects. This study investigates the separate and combined effects of occupational-level silica and ambient-level DEP on lung injury, inflammation, and autoantibody formation in two genetically distinct mouse strains, thereby aiming at understanding the interplay between genetic susceptibility, particulate exposure, and disease outcomes...
February 27, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38368385/effective-density-of-inhaled-environmental-and-engineered-nanoparticles-and-its-impact-on-the-lung-deposition-and-dosimetry
#10
JOURNAL ARTICLE
Denisa Lizonova, Amogh Nagarkar, Philip Demokritou, Georgios A Kelesidis
BACKGROUND: Airborne environmental and engineered nanoparticles (NPs) are inhaled and deposited in the respiratory system. The inhaled dose of such NPs and their deposition location in the lung determines their impact on health. When calculating NP deposition using particle inhalation models, a common approach is to use the bulk material density, ρb , rather than the effective density, ρeff . This neglects though the porous agglomerate structure of NPs and may result in a significant error of their lung-deposited dose and location...
February 17, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38360668/particulate-matter-from-car-exhaust-alters-function-of-human-ipsc-derived-microglia
#11
JOURNAL ARTICLE
Henna Jäntti, Steffi Jonk, Mireia Gómez Budia, Sohvi Ohtonen, Ilkka Fagerlund, Mohammad Feroze Fazaludeen, Päivi Aakko-Saksa, Alice Pebay, Šárka Lehtonen, Jari Koistinaho, Katja M Kanninen, Pasi I Jalava, Tarja Malm, Paula Korhonen
BACKGROUND: Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive functions and increased incidence of neurodegenerative diseases such as Alzheimer's disease. Inhaled components of PM may directly invade the brain via the olfactory route, or act through peripheral system responses resulting in inflammation and oxidative stress in the brain...
February 15, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38321545/influence-of-polyethylene-terephthalate-pet-microplastic-on-selected-active-substances-in-the-intramural-neurons-of-the-porcine-duodenum
#12
JOURNAL ARTICLE
Ismena Gałęcka, Natalia Szyryńska, Jarosław Całka
BACKGROUND: Currently, society and industry generate huge amounts of plastics worldwide. The ubiquity of microplastics is obvious, but its impact on the animal and human organism remains not fully understood. The digestive tract is one of the first barriers between pathogens and xenobiotics and a living organism. Its proper functioning is extremely important in order to maintain homeostasis. The aim of this study was to determine the effect of microplastic on enteric nervous system and histological structure of swine duodenum...
February 6, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38311718/the-in-vitro-gastrointestinal-digestion-associated-protein-corona-of-polystyrene-nano-and-microplastics-increases-their-uptake-by-human-thp-1-derived-macrophages
#13
JOURNAL ARTICLE
Hugo Brouwer, Mojtaba Porbahaie, Sjef Boeren, Mathias Busch, Hans Bouwmeester
BACKGROUND: Micro- and nanoplastics (MNPs) represent one of the most widespread environmental pollutants of the twenty-first century to which all humans are orally exposed. Upon ingestion, MNPs pass harsh biochemical conditions within the gastrointestinal tract, causing a unique protein corona on the MNP surface. Little is known about the digestion-associated protein corona and its impact on the cellular uptake of MNPs. Here, we systematically studied the influence of gastrointestinal digestion on the cellular uptake of neutral and charged polystyrene MNPs using THP-1-derived macrophages...
February 4, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38297341/comparison-of-pet-tracing-and-biodistribution-between-64-cu-labeled-micro-and-nano-polystyrene-in-a-murine-inhalation-model
#14
JOURNAL ARTICLE
Joycie Shanmugiah, Javeria Zaheer, Changkeun Im, Choong Mo Kang, Jin Su Kim
INTRODUCTION: Recent studies showed the presence of microplastic in human lungs. There remains an unmet need to identify the biodistribution of microplastic after inhalation. In this study, we traced the biodistribution of inhaled micro-sized polystyrene (mPS) and/or nano-sized PS (nPS) using 64 Cu with PET in mice. METHODS: We used 0.2-0.3-µm sized mPS and 20-nm sized nPS throughout. 64 Cu-DOTA-mPS, 64 Cu-DOTA-nPS and/or 64 CuCl2 were used to trace the distribution in the murine inhalation model...
January 31, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38297314/malignant-peritoneal-mesotheliomas-of-rats-induced-by-multiwalled-carbon-nanotubes-and-amosite-asbestos-transcriptome-and-epigenetic-profiles
#15
JOURNAL ARTICLE
Stella Marie Reamon-Buettner, Susanne Rittinghausen, Annika Klauke, Andreas Hiemisch, Christina Ziemann
BACKGROUND: Malignant mesothelioma is an aggressive cancer that often originates in the pleural and peritoneal mesothelium. Exposure to asbestos is a frequent cause. However, studies in rodents have shown that certain multiwalled carbon nanotubes (MWCNTs) can also induce malignant mesothelioma. The exact mechanisms are still unclear. To gain further insights into molecular pathways leading to carcinogenesis, we analyzed tumors in Wistar rats induced by intraperitoneal application of MWCNTs and amosite asbestos...
January 31, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38225661/ros-mtros-promotes-tnts-formation-via-the-pi3k-akt-mtor-pathway-to-protect-against-mitochondrial-damages-in-glial-cells-induced-by-engineered-nanomaterials
#16
JOURNAL ARTICLE
Xinpei Lin, Wei Wang, Xiangyu Chang, Cheng Chen, Zhenkun Guo, Guangxia Yu, Wenya Shao, Siying Wu, Qunwei Zhang, Fuli Zheng, Huangyuan Li
BACKGROUND: As the demand and application of engineered nanomaterials have increased, their potential toxicity to the central nervous system has drawn increasing attention. Tunneling nanotubes (TNTs) are novel cell-cell communication that plays a crucial role in pathology and physiology. However, the relationship between TNTs and nanomaterials neurotoxicity remains unclear. Here, three types of commonly used engineered nanomaterials, namely cobalt nanoparticles (CoNPs), titanium dioxide nanoparticles (TiO2 NPs), and multi-walled carbon nanotubes (MWCNTs), were selected to address this limitation...
January 15, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38110964/polystyrene-nanobeads-exacerbate-chronic-colitis-in-mice-involving-in-oxidative-stress-and-hepatic-lipid-metabolism
#17
JOURNAL ARTICLE
Juan Ma, Yin Wan, Lingmin Song, Luchen Wang, Huimei Wang, Yingzhi Li, Danfei Huang
BACKGROUND: Nanoplastics (NPs) are omnipresent in our lives as a new type of pollution with a tiny size. It can enter organisms from the environment, accumulate in the body, and be passed down the food chain. Inflammatory bowel disease (IBD) is a nonspecific intestinal inflammatory disease that is recurrent and prevalent in the population. Given that the intestinal features of colitis may affect the behavior and toxicity of NPs, it is imperative to clarify the risk and toxicity mechanisms of NPs in colitis models...
December 18, 2023: Particle and Fibre Toxicology
https://read.qxmd.com/read/38110941/acute-and-continuous-exposure-of-airborne-fine-particulate-matter-pm-2-5-diverse-outer-blood-retinal-barrier-damages-and-disease-susceptibilities
#18
JOURNAL ARTICLE
Yuzhou Gu, Feiyin Sheng, Mengqin Gao, Li Zhang, Shengjie Hao, Shuying Chen, Rongrong Chen, Yili Xu, Di Wu, Yu Han, Lu Chen, Ye Liu, Bing Lu, Wei Zhao, Xiaoming Lou, Zhijian Chen, Peng Li, Xiaofeng Wang, Ke Yao, Qiuli Fu
BACKGROUND: The association between air pollution and retinal diseases such as age-related macular degeneration (AMD) has been demonstrated, but the pathogenic correlation is unknown. Damage to the outer blood-retinal barrier (oBRB), which consists of the retinal pigment epithelium (RPE) and choriocapillaris, is crucial in the development of fundus diseases. OBJECTIVES: To describe the effects of airborne fine particulate matter (PM2.5 ) on the oBRB and disease susceptibilities...
December 18, 2023: Particle and Fibre Toxicology
https://read.qxmd.com/read/38072983/maternal-exposure-to-nano-titanium-dioxide-impedes-fetal-development-via-endothelial-to-mesenchymal-transition-in-the-placental-labyrinth-in-mice
#19
JOURNAL ARTICLE
Xianjie Li, Yinger Luo, Di Ji, Zhuyi Zhang, Shili Luo, Ya Ma, Wulan Cao, Chunwei Cao, Phei Er Saw, Hui Chen, Yanhong Wei
BACKGROUND: Extensive production and usage of commercially available products containing TiO2 NPs have led to accumulation in the human body. The deposition of TiO2 NPs has even been detected in the human placenta, which raises concerns regarding fetal health. Previous studies regarding developmental toxicity have frequently focused on TiO2 NPs < 50 nm, whereas the potential adverse effects of large-sized TiO2 NPs received less attention. Placental vasculature is essential for maternal-fetal circulatory exchange and ensuring fetal growth...
December 11, 2023: Particle and Fibre Toxicology
https://read.qxmd.com/read/38062420/human-exposure-to-diesel-exhaust-induces-cyp1a1-expression-and-ahr-activation-without-a-coordinated-antioxidant-response
#20
JOURNAL ARTICLE
M Friberg, A F Behndig, J A Bosson, Ala Muala, S Barath, R Dove, D Glencross, F J Kelly, A Blomberg, I S Mudway, T Sandström, J Pourazar
BACKGROUND: Diesel exhaust (DE) induces neutrophilia and lymphocytosis in experimentally exposed humans. These responses occur in parallel to nuclear migration of NF-κB and c-Jun, activation of mitogen activated protein kinases and increased production of inflammatory mediators. There remains uncertainty regarding the impact of DE on endogenous antioxidant and xenobiotic defences, mediated by nuclear factor erythroid 2-related factor 2 (Nrf2) and the aryl hydrocarbon receptor (AhR) respectively, and the extent to which cellular antioxidant adaptations protect against the adverse effects of DE...
December 8, 2023: Particle and Fibre Toxicology
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