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Particle and Fibre Toxicology

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https://www.readbyqxmd.com/read/28330475/in-memorian-thomas-w-hesterberg-phd-mba-1950-2016
#1
David B Warheit
No abstract text is available yet for this article.
March 22, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28327162/biological-effects-of-carbon-black-nanoparticles-are-changed-by-surface-coating-with-polycyclic-aromatic-hydrocarbons
#2
Karina Lindner, Michael Ströbele, Sandra Schlick, Sina Webering, André Jenckel, Johannes Kopf, Olga Danov, Katherina Sewald, Christian Buj, Otto Creutzenberg, Thomas Tillmann, Gerhard Pohlmann, Heinrich Ernst, Christina Ziemann, Gereon Hüttmann, Holger Heine, Henning Bockhorn, Tanja Hansen, Peter König, Heinz Fehrenbach
BACKGROUND: Carbon black nanoparticles (CBNP) are mainly composed of carbon, with a small amount of other elements (including hydrogen and oxygen). The toxicity of CBNP has been attributed to their large surface area, and through adsorbing intrinsically toxic substances, such as polycyclic aromatic hydrocarbons (PAH). It is not clear whether a PAH surface coating changes the toxicological properties of CBNP by influencing their physicochemical properties, through the specific toxicity of the surface-bound PAH, or by a combination of both...
March 21, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28264691/endothelial-responses-of-the-alveolar-barrier-in-vitro-in-a-dose-controlled-exposure-to-diesel-exhaust-particulate-matter
#3
Sebastian G Klein, Sébastien Cambier, Jennifer Hennen, Sylvain Legay, Tommaso Serchi, Inge Nelissen, Aline Chary, Elisa Moschini, Andreas Krein, Brunhilde Blömeke, Arno C Gutleb
BACKGROUND: During the last 250 years, the level of exposure to combustion-derived particles raised dramatically in western countries, leading to increased particle loads in the ambient air. Among the environmental particles, diesel exhaust particulate matter (DEPM) plays a special role because of its omnipresence and reported effects on human health. During recent years, a possible link between air pollution and the progression of atherosclerosis is recognized. A central effect of DEPM is their impact on the endothelium, especially of the alveolar barrier...
March 6, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28253935/particulate-air-pollution-mediated-effects-on-insulin-resistance-in-mice-are-independent-of-ccr2
#4
Cuiqing Liu, Xiaohua Xu, Yuntao Bai, Jixin Zhong, Aixia Wang, Lixian Sun, Liya Kong, Zhekang Ying, Qinghua Sun, Sanjay Rajagopalan
BACKGROUND: Chronic exposure to fine ambient particulate matter (PM2.5) induces insulin resistance. CC-chemokine receptor 2 (CCR2) appears to be essential in diet-induced insulin resistance implicating an important role for systemic cellular inflammation in the process. We have previously suggested that CCR2 is important in PM2.5 exposure-mediated inflammation leading to insulin resistance under high fat diet situation. The present study assessed the importance of CCR2 in PM2.5 exposure-induced insulin resistance in the context of normal diet...
March 3, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28187746/slow-lung-clearance-and-limited-translocation-of-four-sizes-of-inhaled-iridium-nanoparticles
#5
Alison Buckley, James Warren, Alan Hodgson, Tim Marczylo, Konstantin Ignatyev, Chang Guo, Rachel Smith
BACKGROUND: Concerns have been expressed that inhaled nanoparticles may behave differently to larger particles in terms of lung clearance and translocation, with potential implications for their toxicity. Studies undertaken to investigate this have typically involved limited post-exposure periods. There is a shortage of information on longer-term clearance and translocation patterns and their dependence on particle size, which this study aimed to address. METHODS: Rats were exposed (<3 h) nose-only to aerosols of spark-generated radioactive iridium-192 nanoparticles of four sizes: 10 nm, 15 nm, 35 nm and 75 nm (count median diameter) (aerosol mass concentrations 17, 140, 430, and 690 μg/m(3), respectively)...
February 10, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28148272/dose-dependent-induction-of-astrocyte-activation-and-reactive-astrogliosis-in-mouse-brain-following-maternal-exposure-to-carbon-black-nanoparticle
#6
Atsuto Onoda, Ken Takeda, Masakazu Umezawa
BACKGROUND: Recent studies indicate that maternal exposure to ambient ultrafine particles and nanoparticles has adverse effects of on the central nervous system. Quantitative dose-response data is required to better understand the developmental neurotoxicity of nanoparticles. The present study investigated dose-dependent effects of maternal exposure to carbon black nanoparticle (CB-NP) on astrocyte in the brains of mouse offspring. METHODS: A CB-NP suspension (2...
February 2, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28100227/prenatal-and-postnatal-mothering-by-diesel-exhaust-pm2-5-exposed-dams-differentially-program-mouse-energy-metabolism
#7
Minjie Chen, Shuai Liang, Huifen Zhou, Yanyi Xu, Xiaobo Qin, Ziying Hu, Xiaoke Wang, Lianglin Qiu, Wanjun Wang, Yuhao Zhang, Zhekang Ying
BACKGROUND: Obesity is one of the leading threats to global public health. It is consequent to abnormal energy metabolism. Currently, it has been well established that maternal exposure to environmental stressors that cause inappropriate fetal development may have long-term adverse effects on offspring energy metabolism in an exposure timing-dependent manner, known as developmental programming of health and diseases paradigm. Rapidly increasing evidence has indicated that maternal exposure to ambient fine particles (PM2...
January 18, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28069023/in-vitro-biological-responses-to-nanofibrillated-cellulose-by-human-dermal-lung-and-immune-cells-surface-chemistry-aspect
#8
Viviana R Lopes, Carla Sanchez-Martinez, Maria Strømme, Natalia Ferraz
BACKGROUND: Nanocellulose, and particularly nanofibrillated cellulose (NFC), has been proposed for a diversity of applications in industry and in the biomedical field. Its unique physicochemical and structural features distinguish nanocellulose from traditional materials and enable its use as an advance nanomaterial. However, its nanoscale features may induce unknown biological responses. Limited studies with NFC are available and the biological impacts of its use have not been thoroughly explored...
January 10, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28069010/nanoparticle-exposure-reactivates-latent-herpesvirus-and-restores-a-signature-of-acute-infection
#9
Christine Sattler, Franco Moritz, Shanze Chen, Beatrix Steer, David Kutschke, Martin Irmler, Johannes Beckers, Oliver Eickelberg, Philippe Schmitt-Kopplin, Heiko Adler, Tobias Stoeger
BACKGROUND: Inhalation of environmental (nano) particles (NP) as well as persistent herpesvirus-infection are potentially associated with chronic lung disease and as both are omnipresent in human society a coincidence of these two factors is highly likely. We hypothesized that NP-exposure of persistently herpesvirus-infected cells as a second hit might disrupt immune control of viral latency, provoke reactivation of latent virus and eventually lead to an inflammatory response and tissue damage...
January 10, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27955700/combined-exposure-of-diesel-exhaust-particles-and-respirable-soufri%C3%A3-re-hills-volcanic-ash-causes-a-pro-inflammatory-response-in-an-in-vitro-multicellular-epithelial-tissue-barrier-model
#10
Ines Tomašek, Claire J Horwell, David E Damby, Hana Barošová, Christoph Geers, Alke Petri-Fink, Barbara Rothen-Rutishauser, Martin J D Clift
BACKGROUND: There are justifiable health concerns regarding the potential adverse effects associated with human exposure to volcanic ash (VA) particles, especially when considering communities living in urban areas already exposed to heightened air pollution. The aim of this study was, therefore, to gain an imperative, first understanding of the biological impacts of respirable VA when exposed concomitantly with diesel particles. METHODS: A sophisticated in vitro 3D triple cell co-culture model of the human alveolar epithelial tissue barrier was exposed to either a single or repeated dose of dry respirable VA (deposited dose of 0...
December 12, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27955691/early-kidney-damage-induced-by-subchronic-exposure-to-pm2-5-in-rats
#11
O G Aztatzi-Aguilar, M Uribe-Ramírez, J Narváez-Morales, A De Vizcaya-Ruiz, O Barbier
BACKGROUND: Particulate matter exposure is associated with respiratory and cardiovascular system dysfunction. Recently, we demonstrated that fine particles, also named PM2.5, modify the expression of some components of the angiotensin and bradykinin systems, which are involved in lung, cardiac and renal regulation. The endocrine kidney function is associated with the regulation of angiotensin and bradykinin, and it can suffer damage even as a consequence of minor alterations of these systems...
December 12, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27938386/erratum-to-quantification-of-the-cellular-dose-and-characterization-of-nanoparticle-transport-during-in-vitro-testing
#12
Grigore Rischitor, Mariantonietta Parracino, Rita La Spina, Patricia Urbán, Isaac Ojea-Jiménez, Elena Bellido, Andrea Valsesia, Sabrina Gioria, Robin Capomaccio, Agnieszka Kinsner-Ovaskainen, Douglas Gilliland, François Rossi, Pascal Colpo
No abstract text is available yet for this article.
December 9, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27906031/contrasting-biological-potency-of-particulate-matter-collected-at-sites-impacted-by-distinct-industrial-sources
#13
Errol M Thomson, Dalibor Breznan, Subramanian Karthikeyan, Christine MacKinnon-Roy, Ngoc Q Vuong, Ewa Dabek-Zlotorzynska, Valbona Celo, Jean-Pierre Charland, Prem Kumarathasan, Jeffrey R Brook, Renaud Vincent
BACKGROUND: Industrial sources contribute a significant proportion of anthropogenic particulate matter (PM) emissions, producing particles of varying composition that may differentially impact health. This study investigated the in vitro toxicity of ambient PM collected near industrial sites in relation to particle size and composition. METHODS: Size-fractionated particles (ultrafine, PM0.1-2.5, PM2.5-10, PM>10) were collected in the vicinity of steel, copper, aluminium, and petrochemical industrial sites...
December 1, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27906023/surface-area-dependence-of-gas-particle-interactions-influences-pulmonary-and-neuroinflammatory-outcomes
#14
Christina R Tyler, Katherine E Zychowski, Bethany N Sanchez, Valeria Rivero, Selita Lucas, Guy Herbert, June Liu, Hammad Irshad, Jacob D McDonald, Barry E Bleske, Matthew J Campen
BACKGROUND: Deleterious consequences of exposure to traffic emissions may derive from interactions between carbonaceous particulate matter (PM) and gaseous components in a manner that is dependent on the surface area or complexity of the particles. To determine the validity of this hypothesis, we examined pulmonary and neurological inflammatory outcomes in C57BL/6 and apolipoprotein E knockout (ApoE(-/-)) male mice after acute and chronic exposure to vehicle engine-derived particulate matter, generated as ultrafine (UFP) and fine (FP) sizes, with additional exposures using UFP or FP combined with gaseous copollutants derived from fresh gasoline and diesel emissions, labeled as UFP + G and FP + G...
December 1, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27899122/endocytosed-nanoparticles-hold-endosomes-and-stimulate-binucleated-cells-formation
#15
Lin Xia, Weihong Gu, Mingyi Zhang, Ya-Nan Chang, Kui Chen, Xue Bai, Lai Yu, Juan Li, Shan Li, Gengmei Xing
BACKGROUND: Nanotechnology developed rapidly in cellular diagnosis and treatment, the endocytic system was an important pathway for targeting cell. In the research of developing macrophages as drug carriers or important therapeutic targets, an interesting phenomenon, internalized nanoparticles induced to form binucleated macrophages, was found although the particles dose did not cause obvious cytotoxicity. RESULTS: Under 25 μg/ml, internalized 30 nm polystyrene beads(30 nm Ps nanoparticles) induced the formation of binucleated macrophages when they entered into endosomes via the endocytic pathway...
November 29, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27888833/interaction-of-rat-alveolar-macrophages-with-dental-composite-dust
#16
K L Van Landuyt, S M Cokic, C Asbach, P Hoet, L Godderis, F X Reichl, B Van Meerbeek, A Vennemann, M Wiemann
BACKGROUND: Dental composites have become the standard filling material to restore teeth, but during the placement of these restorations, high amounts of respirable composite dust (<5 μm) including many nano-sized particles may be released in the breathing zone of the patient and dental operator. Here we tested the respirable fraction of several composite particles for their cytotoxic effect using an alveolar macrophage model system. ​METHODS: Composite dust was generated following a clinical protocol, and the dust particles were collected under sterile circumstances...
November 26, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27881140/early-signs-of-multi-walled-carbon-nanotbues-degradation-in-macrophages-via-an-intracellular-ph-dependent-biological-mechanism-importance-of-length-and-functionalization
#17
Marion Landry, Mathieu Pinault, Stéphane Tchankouo, Émeline Charon, Audrey Ridoux, Jorge Boczkowski, Martine Mayne-L'Hermite, Sophie Lanone
BACKGROUND: Carbon nanotubes (CNT) can interact with the biological environment, which could participate in their associated toxicity. We recently demonstrated that pH is an important player of CNT fate inside macrophages. We wanted to further characterize such process, and therefore designed a study dedicated to decipher CNT biodegradation by macrophages, as a function of two major physico-chemical properties in regard with nanotoxicology; length and degree of functionalization. To achieve our aim, we synthesized, following a single initial production process, four MWCNT differing in length and/or surface chemistry: S-CNT (short), SF-CNT (short functionalized), L-CNT (long) and LF-CNT (long functionalized)...
November 24, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27814761/comment-on-shvedova-et-al-2016-gender-differences-in-murine-pulmonary-responses-elicited-by-cellulose-nanocrystals
#18
LETTER
Jo Anne Shatkin, Günter Oberdörster
A recent publication in "Particle and Fibre Toxicology" reported on the gender differences in pulmonary toxicity from oro-pharyngeal aspiration of a high dose of cellulose nanocrystals. The study is timely given the growing interest in diverse commercial applications of cellulose nanomaterials, and the need for studies addressing pulmonary toxicity. The results from this study are interesting and can be strengthened with a discussion of how differences in the weights of female and male C57BL/6 mice was accounted for...
November 4, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27814727/myofibroblasts-and-lung-fibrosis-induced-by-carbon-nanotube-exposure
#19
REVIEW
Jie Dong, Qiang Ma
Carbon nanotubes (CNTs) are newly developed materials with unique properties and a range of industrial and commercial applications. A rapid expansion in the production of CNT materials may increase the risk of human exposure to CNTs. Studies in rodents have shown that certain forms of CNTs are potent fibrogenic inducers in the lungs to cause interstitial, bronchial, and pleural fibrosis characterized by the excessive deposition of collagen fibers and the scarring of involved tissues. The cellular and molecular basis underlying the fibrotic response to CNT exposure remains poorly understood...
November 4, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27919268/air-liquid-interface-exposure-to-aerosols-of-poorly-soluble-nanomaterials-induces-different-biological-activation-levels-compared-to-exposure-to-suspensions
#20
COMPARATIVE STUDY
Thomas Loret, Emmanuel Peyret, Marielle Dubreuil, Olivier Aguerre-Chariol, Christophe Bressot, Olivier le Bihan, Tanguy Amodeo, Bénédicte Trouiller, Anne Braun, Christophe Egles, Ghislaine Lacroix
BACKGROUND: Recently, much progress has been made to develop more physiologic in vitro models of the respiratory system and improve in vitro simulation of particle exposure through inhalation. Nevertheless, the field of nanotoxicology still suffers from a lack of relevant in vitro models and exposure methods to predict accurately the effects observed in vivo, especially after respiratory exposure. In this context, the aim of our study was to evaluate if exposing pulmonary cells at the air-liquid interface to aerosols of inhalable and poorly soluble nanomaterials generates different toxicity patterns and/or biological activation levels compared to classic submerged exposures to suspensions...
November 3, 2016: Particle and Fibre Toxicology
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