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Particle and Fibre Toxicology

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https://www.readbyqxmd.com/read/29157272/mechanistic-insight-into-the-impact-of-nanomaterials-on-asthma-and-allergic-airway-disease
#1
REVIEW
Kirsty Meldrum, Chang Guo, Emma L Marczylo, Timothy W Gant, Rachel Smith, Martin O Leonard
Asthma is a chronic respiratory disease known for its high susceptibility to environmental exposure. Inadvertent inhalation of engineered or incidental nanomaterials is a concern for human health, particularly for those with underlying disease susceptibility. In this review we provide a comprehensive analysis of those studies focussed on safety assessment of different nanomaterials and their unique characteristics on asthma and allergic airway disease. These include in vivo and in vitro approaches as well as human and population studies...
November 21, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29132433/impaired-ciliogenesis-in-differentiating-human-bronchial-epithelia-exposed-to-non-cytotoxic-doses-of-multi-walled-carbon-nanotubes
#2
Ryan J Snyder, Salik Hussain, Charles J Tucker, Scott H Randell, Stavros Garantziotis
BACKGROUND: Multi-walled carbon nanotubes (MWCNTs) are engineered nanomaterials used for a variety of industrial and consumer products. Their high tensile strength, hydrophobicity, and semi-conductive properties have enabled many novel applications, increasing the possibility of accidental nanotube inhalation by either consumers or factory workers. While MWCNT inhalation has been previously shown to cause inflammation and pulmonary fibrosis at high doses, the susceptibility of differentiating bronchial epithelia to MWCNT exposure remains unexplored...
November 13, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29100528/silica-nanoparticles-inhibit-the-cation-channel-trpv4-in-airway-epithelial-cells
#3
Alicia Sanchez, Julio L Alvarez, Kateryna Demydenko, Carole Jung, Yeranddy A Alpizar, Julio Alvarez-Collazo, Stevan M Cokic, Miguel A Valverde, Peter H Hoet, Karel Talavera
BACKGROUND: Silica nanoparticles (SiNPs) have numerous beneficial properties and are extensively used in cosmetics and food industries as anti-caking, densifying and hydrophobic agents. However, the increasing exposure levels experienced by the general population and the ability of SiNPs to penetrate cells and tissues have raised concerns about possible toxic effects of this material. Although SiNPs are known to affect the function of the airway epithelium, the molecular targets of these particles remain largely unknown...
November 3, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29084556/protein-corona-implications-for-nanoparticle-interactions-with-pulmonary-cells
#4
Nagarjun V Konduru, Ramon M Molina, Archana Swami, Flavia Damiani, Georgios Pyrgiotakis, Paulo Lin, Patrizia Andreozzi, Thomas C Donaghey, Philip Demokritou, Silke Krol, Wolfgang Kreyling, Joseph D Brain
BACKGROUND: We previously showed that cerium oxide (CeO2), barium sulfate (BaSO4) and zinc oxide (ZnO) nanoparticles (NPs) exhibited different lung toxicity and pulmonary clearance in rats. We hypothesize that these NPs acquire coronas with different protein compositions that may influence their clearance from the lungs. METHODS: CeO2, silica-coated CeO2, BaSO4, and ZnO NPs were incubated in rat lung lining fluid in vitro. Then, gel electrophoresis followed by quantitative mass spectrometry was used to characterize the adsorbed proteins stripped from these NPs...
October 30, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29073907/multiparametric-analysis-of-anti-proliferative-and-apoptotic-effects-of-gold-nanoprisms-on-mouse-and-human-primary-and-transformed-cells-biodistribution-and-toxicity-in-vivo
#5
Marta Pérez-Hernández, María Moros, Grazyna Stepien, Pablo Del Pino, Sebastián Menao, Marcelo de Las Heras, Maykel Arias, Scott G Mitchell, Beatriz Pelaz, Eva M Gálvez, Jesús M de la Fuente, Julián Pardo
BACKGROUND: The special physicochemical properties of gold nanoprisms make them very useful for biomedical applications including biosensing and cancer therapy. However, it is not clear how gold nanoprisms may affect cellular physiology including viability and other critical functions. We report a multiparametric investigation on the impact of gold-nanoprisms on mice and human, transformed and primary cells as well as tissue distribution and toxicity in vivo after parental injection. METHODS: Cellular uptake of the gold-nanoprisms (NPRs) and the most crucial parameters of cell fitness such as generation of reactive oxygen species (ROS), mitochondria membrane potential, cell morphology and apoptosis were systematically assayed in cells...
October 26, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29029643/an-integrated-methodology-for-assessing-the-impact-of-food-matrix-and-gastrointestinal-effects-on-the-biokinetics-and-cellular-toxicity-of-ingested-engineered-nanomaterials
#6
Glen M DeLoid, Yanli Wang, Klara Kapronezai, Laura Rubio Lorente, Roujie Zhang, Georgios Pyrgiotakis, Nagarjun V Konduru, Maria Ericsson, Jason C White, Roberto De La Torre-Roche, Hang Xiao, David Julian McClements, Philip Demokritou
BACKGROUND: Engineered nanomaterials (ENMs) are increasingly added to foods to improve their quality, sensory appeal, safety and shelf-life. Human exposure to these ingested ENMs (iENMS) is inevitable, yet little is known of their hazards. To assess potential hazards, efficient in vitro methodologies are needed to evaluate particle biokinetics and toxicity. These methodologies must account for interactions and transformations of iENMs in foods (food matrix effect) and in the gastrointestinal tract (GIT) that are likely to determine nano-biointeractions...
October 13, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28969663/in-vitro-toxicoproteomic-analysis-of-a549-human-lung-epithelial-cells-exposed-to-urban-air-particulate-matter-and-its-water-soluble-and-insoluble-fractions
#7
Ngoc Q Vuong, Dalibor Breznan, Patrick Goegan, Julie S O'Brien, Andrew Williams, Subramanian Karthikeyan, Premkumari Kumarathasan, Renaud Vincent
BACKGROUND: Toxicity of airborne particulate matter (PM) is difficult to assess because PM composition is complex and variable due to source contribution and atmospheric transformation. In this study, we used an in vitro toxicoproteomic approach to identify the toxicity mechanisms associated with different subfractions of Ottawa urban dust (EHC-93). METHODS: A549 human lung epithelial cells were exposed to 0, 60, 140 and 200 μg/cm(2) doses of EHC-93 (total), its insoluble and soluble fractions for 24 h...
October 2, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28923112/cobalt-nanoparticles-induce-lung-injury-dna-damage-and-mutations-in-mice
#8
Rong Wan, Yiqun Mo, Zhenyu Zhang, Mizu Jiang, Shichuan Tang, Qunwei Zhang
BACKGROUND: We and other groups have demonstrated that exposure to cobalt nanoparticles (Nano-Co) caused oxidative stress and inflammation, which have been shown to be strongly associated with genotoxic and carcinogenic effects. However, few studies have reported Nano-Co-induced genotoxic effects in vivo. Here, we propose that Nano-Co may have high genotoxic effects due to their small size and high surface area, which have high capacity for causing oxidative stress and inflammation. METHODS: gpt delta transgenic mice were used as our in vivo study model...
September 18, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28903780/stat-6-signaling-pathway-and-not-interleukin-1-mediates-multi-walled-carbon-nanotube-induced-lung-fibrosis-in-mice-insights-from-an-adverse-outcome-pathway-framework
#9
Jake Nikota, Allyson Banville, Laura Rose Goodwin, Dongmei Wu, Andrew Williams, Carole Lynn Yauk, Håkan Wallin, Ulla Vogel, Sabina Halappanavar
BACKGROUND: The accumulation of MWCNTs in the lung environment leads to inflammation and the development of disease similar to pulmonary fibrosis in rodents. Adverse Outcome Pathways (AOPs) are a framework for defining and organizing the key events that comprise the biological changes leading to undesirable events. A putative AOP has been developed describing MWCNT-induced pulmonary fibrosis; inflammation and the subsequent healing response induced by inflammatory mechanisms have been implicated in disease progression...
September 13, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28893276/imipramine-blocks-acute-silicosis-in-a-mouse-model
#10
Rupa Biswas, Kevin L Trout, Forrest Jessop, Jack R Harkema, Andrij Holian
BACKGROUND: Inhalation of crystalline silica is associated with pulmonary inflammation and silicosis. Although silicosis remains a prevalent health problem throughout the world, effective treatment choices are limited. Imipramine (IMP) is a FDA approved tricyclic antidepressant drug with lysosomotropic characteristics. The aim of this study was to evaluate the potential for IMP to reduce silicosis and block phagolysosome membrane permeabilization. METHODS: C57BL/6 alveolar macrophages (AM) exposed to crystalline silica ± IMP in vitro were assessed for IL-1β release, cytotoxicity, particle uptake, lysosomal stability, and acid sphingomyelinase activity...
September 11, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28854940/diesel-engine-exhaust-accelerates-plaque-formation-in-a-mouse-model-of-alzheimer-s-disease
#11
Maja Hullmann, Catrin Albrecht, Damiën van Berlo, Miriam E Gerlofs-Nijland, Tina Wahle, Agnes W Boots, Jean Krutmann, Flemming R Cassee, Thomas A Bayer, Roel P F Schins
BACKGROUND: Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor to particulate air pollution in urban environments, can aggravate Alzheimer's Disease (AD)-like effects in female 5X Familial AD (5XFAD) mice and their wild-type female littermates. Following 3 and 13 weeks exposures to diluted DEE (0...
August 30, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28851397/nf-%C3%AE%C2%BAb-regulated-microrna-574-5p-underlies-synaptic-and-cognitive-impairment-in-response-to-atmospheric-pm2-5-aspiration
#12
Tingting Ku, Ben Li, Rui Gao, Yingying Zhang, Wei Yan, Xiaotong Ji, Guangke Li, Nan Sang
BACKGROUND: PM2.5 (particulate matter ≤ 2.5 μm) is one of the leading environmental risk factors for the global burden of disease. Whereas increasing evidence has linked the adverse roles of PM2.5 with cardiovascular and respiratory diseases, limited but growing emerging evidence suggests that PM2.5 exposure can affect the nervous system, causing neuroinflammation, synaptic dysfunction and cognitive deterioration. However, the molecular mechanisms underlying the synaptic and cognitive deficits elicited by PM2...
August 29, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28851387/erratum-to-reduction-of-pulmonary-toxicity-of-metal-oxide-nanoparticles-by-phosphonate-based-surface-passivation
#13
Xiaoming Cai, Anson Lee, Zhaoxia Ji, Cynthia Huang, Chong Hyun Chang, Xiang Wang, Yu-Pei Liao, Tian Xia, Ruibin Li
No abstract text is available yet for this article.
August 29, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28899404/extracellular-vesicle-packaged-mirna-release-after-short-term-exposure-to-particulate-matter-is-associated-with-increased-coagulation
#14
Laura Pergoli, Laura Cantone, Chiara Favero, Laura Angelici, Simona Iodice, Eva Pinatel, Mirjam Hoxha, Laura Dioni, Marilena Letizia, Benedetta Albetti, Letizia Tarantini, Federica Rota, Pier Alberto Bertazzi, Amedea Silvia Tirelli, Vincenza Dolo, Andrea Cattaneo, Luisella Vigna, Cristina Battaglia, Michele Carugno, Matteo Bonzini, Angela Cecilia Pesatori, Valentina Bollati
BACKGROUND: Exposure to particulate matter (PM) is associated with increased incidence of cardiovascular disease and increased coagulation, but the molecular mechanisms underlying these associations remain unknown. Obesity may increase susceptibility to the adverse effects of PM exposure, exacerbating the effects on cardiovascular diseases. Extracellular vesicles (EVs), which travel in body fluids and transfer microRNAs (miRNAs) between tissues, might play an important role in PM-induced cardiovascular risk...
August 24, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28835236/impact-of-copper-oxide-nanomaterials-on-differentiated-and-undifferentiated-caco-2-intestinal-epithelial-cells-assessment-of-cytotoxicity-barrier-integrity-cytokine-production-and-nanomaterial-penetration
#15
Victor C Ude, David M Brown, Luca Viale, Nilesh Kanase, Vicki Stone, Helinor J Johnston
BACKGROUND: Copper oxide nanomaterials (CuO NMs) are exploited in a diverse array of products including antimicrobials, inks, cosmetics, textiles and food contact materials. There is therefore a need to assess the toxicity of CuO NMs to the gastrointestinal (GI) tract since exposure could occur via direct oral ingestion, mucocillary clearance (following inhalation) or hand to mouth contact. METHODS: Undifferentiated Caco-2 intestinal cells were exposed to CuO NMs (10 nm) at concentrations ranging from 0...
August 23, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28830530/prenatal-tobacco-smoke-exposure-predisposes-offspring-mice-to-exacerbated-allergic-airway-inflammation-associated-with-altered-innate-effector-function
#16
Maria Ferrini, Sophia Carvalho, Yoon Hee Cho, Britten Postma, Lucas Miranda Marques, Kent Pinkerton, Kevan Roberts, Zeina Jaffar
BACKGROUND: Epidemiological studies suggest that prenatal and early life environmental exposures have adverse effects on pulmonary function and are important contributors in the development of childhood asthma and allergic disease. The mechanism by which environmental tobacco smoke (ETS) exposure in utero promotes the development of allergic asthma remains unclear. In this study, we investigated the immunological consequences of prenatal exposure to ETS in order to understand events responsible for the development or exacerbation of allergic asthma...
August 22, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28784145/composition-respirable-fraction-and-dissolution-rate-of-24-stone-wool-mmvf-with-their-binder
#17
Wendel Wohlleben, Hubert Waindok, Björn Daumann, Kai Werle, Melanie Drum, Heiko Egenolf
BACKGROUND: Man-made vitreous fibres (MMVF) are produced on a large scale for thermal insulation purposes. After extensive studies of fibre effects in the 1980ies and 1990ies, the composition of MMVF was modified to reduce the fibrotic and cancerogenic potential via reduced biopersistence. However, occupational risks by handling, applying, disposing modern MMVF may be underestimated as the conventional regulatory classification -combining composition, in-vivo clearance and effects- seems to be based entirely on MMVF after removal of the binder...
August 7, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28764715/comparison-between-micro-and-nanosized-copper-oxide-and-water-soluble-copper-chloride-interrelationship-between-intracellular-copper-concentrations-oxidative-stress-and-dna-damage-response-in-human-lung-cells
#18
Bettina Maria Strauch, Rebecca Katharina Niemand, Nicola Lisa Winkelbeiner, Andrea Hartwig
BACKGROUND: Nano- and microscale copper oxide particles (CuO NP, CuO MP) are applied for manifold purposes, enhancing exposure and thus the potential risk of adverse health effects. Based on the pronounced in vitro cytotoxicity of CuO NP, systematic investigations on the mode of action are required. Therefore, the impact of CuO NP, CuO MP and CuCl2 on the DNA damage response on transcriptional level was investigated by quantitative gene expression profiling via high-throughput RT-qPCR...
August 1, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28728598/multi-walled-carbon-nanotubes-induced-alterations-in-microrna-let-7-and-its-targets-activate-a-protection-mechanism-by-conferring-a-developmental-timing-control
#19
Li Zhao, Hanxiao Wan, Qizhan Liu, Dayong Wang
No abstract text is available yet for this article.
July 20, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28716119/stat1-dependent-and-independent-pulmonary-allergic-and-fibrogenic-responses-in-mice-after-exposure-to-tangled-versus-rod-like-multi-walled-carbon-nanotubes
#20
Katherine S Duke, Alexia J Taylor-Just, Mark D Ihrie, Kelly A Shipkowski, Elizabeth A Thompson, Erinn C Dandley, Gregory N Parsons, James C Bonner
BACKGROUND: Pulmonary toxicity of multi-walled carbon nanotubes (MWCNTs) is influenced by physicochemical characteristics and genetic susceptibility. We hypothesized that contrasting rigidities of tangled (t) versus rod-like (r) MWCNTs would result in differing immunologic or fibrogenic responses in mice and that these responses would be exaggerated in transgenic mice lacking the signal transducer and activator of transcription-1 (STAT1), a susceptible mouse model of pulmonary fibrosis...
July 17, 2017: Particle and Fibre Toxicology
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