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Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences

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https://www.readbyqxmd.com/read/30181759/attenuation-of-lipid-peroxidation-and-atherogenic-factors-in-diabetic-patients-treated-with-gliclazide-and-metformin
#1
Sujan Banik, Mohammad Salim Hossain, Rita Bhatta, Mariyam Akter
Background: Diabetes is associated with oxidative stress and considered as a major risk factor for cardiac disease. We attempted to investigate the role of oral antidiabetic (OAD) agents gliclazide and metformin in lowering the lipid peroxidation and managing the risk for cardiovascular (CV) complications in diabetic patients in comparison with nondiabetic healthy individuals. Materials and Methods: This cross-sectional study was comprised of 150 individuals grouped in three, namely, Group A ( n = 60) healthy volunteers, Group B ( n = 30) newly diagnosed diabetes, and Group C ( n = 60) diabetes treated with OAD...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181758/how-may-doppler-indices-help-in-the-differentiation-of-obstructive-from-nonobstructive-hydronephrosis
#2
Maryam Riahinezhad, Amir Hossein Sarrami, Alaleh Gheisari, Omid Shafaat, Alireza Merikhi, Mehdi Karami, Maryam Farghadani, Masoud Moslehi
Background: We assess the potency of different Doppler indices in the differentiation of obstructive and nonobstructive hydronephrosis. Materials and Methods: In this study, infants and children who were referred for the evaluation of unilateral hydronephrosis were enrolled. Ultrasonography for the assessment of the degree of hydronephrosis and a voiding cystourethrogram for the exclusion of vesicoureteral reflux was performed. Then, Doppler ultrasonography was done for both kidneys of each patient using four classic Doppler indices as well as the difference (delta) of each index between to kidneys...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181757/vitamin-d-the-gut-microbiome-and-inflammatory-bowel-disease
#3
REVIEW
Seyed-Amir Tabatabaeizadeh, Niayesh Tafazoli, Gordon A Ferns, Amir Avan, Majid Ghayour-Mobarhan
Vitamin D has an important role in bone metabolism but recently has been recognized as an immunoregulator, and this has led to investigations on the effect of Vitamin D supplementation in various autoimmune diseases and its anti-inflammatory effects. There is some evidence that Vitamin D can regulate gastrointestinal inflammation. In addition, previous studies have shown that Vitamin D can affect the gut microbiome. The aim of this review is to evaluate the effect of Vitamin D on inflammatory processes, especially its relation to the inflammatory bowel disease (IBD) and gut microbiome...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181756/unmet-health-care-needs-in-people-with-disabilities-an-evidence-to-make-reforms-in-health-insurance-programs-in-iran
#4
Shahin Soltani
No abstract text is available yet for this article.
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181755/comparison-of-the-effects-of-pegylated-granulocyte-colony-stimulating-factor-and-granulocyte-colony-stimulating-factor-on-cytopenia-induced-by-dose-dense-chemotherapy-in-breast-cancer-patients
#5
Farzaneh Ashrafi, Mehrzad Salmasi
Background: Myelosuppression is one of the frequent side effects of chemotherapy in breast cancer patients. Granulocyte-colony stimulating factor (G-CSF) and pegylated G-CSF are used for the prevention of neutropenia after chemotherapy. Pegylated G-CSF has longer half-life of action and can be used as a single dose in comparison to G-CSF. The aim of this study is to compare the grade of cytopenia and side effects between G-CSF and biosimilar pegylated G-CSF in breast cancer patients treated with dose-dense chemotherapy...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181754/pulse-wave-analyzed-cardiovascular-parameters-in-young-first-degree-relatives-of-hypertensives
#6
Jayesh Dalpatbhai Solanki, Hemant B Mehta, Chinmay J Shah
Background: First-degree relatives (FDRs) of hypertensive (HT) are predisposed to hypertension (HTN) which accelerates cardiovascular aging. Same can be studied noninvasively by pulse wave analysis (PWA), encompassing central hemodynamics such as central blood pressure (cBP), cardiac output, and stroke work (SW) and vascular stiffness parameters such as pulse wave velocity (PWV) and augmentation index at HR 75 (AIx@75). We studied PWA-derived cardiovascular parameters in FDRs of HT compared to controls...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181753/serum-levels-of-serotonin-as-a-biomarker-of-newly-diagnosed-fibromyalgia-in-women-its-relation-to-the-platelet-indices
#7
Marwan S M Al-Nimer, Talar A Merza Mohammad, Riyadh A Alsakeni
Background: This study aimed to assess the serum serotonin levels in the newly diagnosed fibromyalgia (FM) and to relate these levels to the presenting signs and symptoms. Materials and Methods: This case-control study included 35 healthy women (Group I) served as controls and 130 women with newly diagnosed FM (Group II). The diagnosis of FM was confirmed by the diagnostic criteria of the American College of Rheumatology-10. The assessment of pain using a revised fibromyalgia impact questionnaire and tender points scoring, blood platelet indices, and serum serotonin levels were determined...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181752/rare-histological-subtype-of-pulmonary-artery-intimal-sarcoma-diagnosed-by-multidisciplinary-approach
#8
Jelena Stojšić, Marko Popović, Tatjana Adžić-Vukicevic, Jelena D Kovač, Jelena Marković, Ana Blanka-Protic, Dragan Radovanović
Pulmonary artery intimal sarcoma (PAS) is a rare mesenchymal tumor mostly diagnosed in middle-aged women. In a 63-year-old female, the radiological findings showed cavitation in the left upper lobe of the lung and infiltrative tumor mass around the left pulmonary artery. PAS consisted of small, round tumor cells with about 80% of mitotic activity and with myxoid background and specific immunoprofile and diagnosed as undifferentiated sarcoma with round cell features type. The final diagnosis of PAS was established according to the pathohistological, chest computed tomography scan, and surgery finding...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181751/serum-based-microrna-biomarkers-for-major-depression-mir-16-mir-135a-and-mir-1202
#9
Ali Gheysarzadeh, Nourkhoda Sadeghifard, Loghman Afraidooni, Farahnaz Pooyan, Mohammad Reza Mofid, Hassan Valadbeigi, Hadi Bakhtiari, Sattar Keikhavani
Background: Depression is a common medical condition with a high prevalence leading to emotional abnormality. Despite some drawbacks, depression currently diagnosed using a combination of patient interviews and self-report questionnaires. Recently, there is emerging emphasis to establish biomarkers to diagnosis and clinical management of depression. This case-control study was designed to develop microRNA (miRNA)-based serum biomarker for depression. Materials and Methods: In this study, 39 patients with depression and 36 healthy controls were enrolled...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181750/chemotherapy-related-infectious-complications-in-patients-with-hematologic-malignancies
#10
Raluca-Ana Rusu, Dana Sîrbu, Daniela Curşeu, Bogdana Năsui, Mădălina Sava, Ştefan Cristian Vesa, Anca Bojan, Cosmin Lisencu, Monica Popa
Background: The objective of the present study was to determine the association between chemotherapy and infectious complications in patients diagnosed with Hematologic malignancies (HMs). Materials and Methods: The study included 463 patients diagnosed with HMs multiple myeloma (MM), Hodgkin's lymphoma (HL), non-HL (NHL), acute myeloid leukemia (AML), acute lymphocytic leukemia, chronic lymphocytic leukemia, and chronic myeloid leukemia, between January 2014 and June 2015...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181749/the-association-between-index-of-nutritional-quality-and-ulcerative-colitis-a-case-control-study
#11
Farhad Vahid, Samaneh Rashvand, Mahya Sadeghi, Azita Hekmatdoost
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. Recent studies have shown that dietary factors play an important role in the development of UC. Index of Nutritional Quality (INQ) is a suitable method that analyzes quantitatively and qualitatively single foods, meals, and diets. The aim of this study was to determine the association between INQ and UC. Materials and Methods: Overall, 62 newly diagnosed cases with UC and 124 healthy age- and sex-matched controls were studied in a referral hospital in Tabriz, Iran...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181748/a-rare-complication-of-nasogastric-tube-insertion
#12
Gheshlaghi Farzad, Nastaran Eizadi-Mood, Shayan Gheshlaghi
No abstract text is available yet for this article.
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181747/comparison-of-support-vector-machine-based-on-genetic-algorithm-with-logistic-regression-to-diagnose-obstructive-sleep-apnea
#13
Zohreh Manoochehri, Nader Salari, Mansour Rezaei, Habibolah Khazaie, Sara Manoochehri, Behnam Khaledi Pavah
Background: Diagnosing of obstructive sleep apnea (OSA) is an important subject in medicine. This study aimed to compare the performance of two data mining techniques, support vector machine (SVM), and logistic regression (LR), in diagnosing OSA. The best-fit model was used as a substitute for polysomnography (PSG), which is the gold standard for diagnosing this disease. Materials and Methods: A total of 250 patients with sleep problems complaints and whose disease had been diagnosed by PSG and referred to the Sleep Disorders Research Center of Farabi Hospital, Kermanshah, between 2012 and 2015 were recruited in this study...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181746/can-routine-peripheral-blood-counts-like-neutrophil-to-lymphocyte-ratio-be-beneficial-in-prediagnosis-of-testicular-cancer-and-its-stages
#14
Kaan Gokcen, Gokce Dundar, Halil Gulbahar, Gokhan Gokce, Emin Yener Gultekin
Background: The purpose of this study was to assess the diagnostic role of preoperative hematological parameters, especially neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in germ cell testicular malignancies and their prediagnostic role in staging of testicular cancer. Materials and Methods: In this cross-sectional retrospective study, we analyzed 39 patients who underwent radical orchiectomy due to a testicular cancer (Group 1) and 82 patients on whom varicocelectomy procedure was performed as control group (Group 2) between January 2006 and January 2016 in our clinic...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181745/-mycobacterium-tuberculosis-and-lipids-insights-into-molecular-mechanisms-from-persistence-to-virulence
#15
REVIEW
Ciamak Ghazaei
Mycobacterium tuberculosis is a causative agent of tuberculosis that causes deaths across the world. The pathogen apart from causing disease manifestations can also enter into a phase of latency to re-emerge later. Among the various factors associated with the virulence of pathogen, the lipids composing the cell wall of the bacillus have drawn much interest among. The unique composition of the cell wall composed of mycolic acid, glycolipids such as diacyltrehaloses, polyacyltrehalose, lipomannan, lipoarabinomannan (LAM), mannose-capped-LAM, sulfolipids, and trehalose-6,6'-dimycolate, all have been implicated in providing the pathogen an advantage in the host...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181744/the-relationship-between-l-leucine-7-amido-4-methyl-coumarin-1-gene-polymorphism-and-susceptibility-to-the-chronic-hepatitis-b-virus-infection-in-an-iranian-population
#16
Bita Moudi, Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb, Parisa Farrokh
Background: Lamnin has important effects on human immunity system. The current study aimed to assess the role of L-leucine-7-amido-4-methyl coumarin 1 gene polymorphisms on hepatitis B virus (HBV) susceptibility. Materials and Methods: The rs20558, rs20563, rs10911193, rs10911251 , and rs1413390 polymorphisms were analyzed using polymerase chain reaction (PCR) and PCR-reaction-restriction fragment-length polymorphism and amplification-refractory mutation system-PCR using three different groups including chronic HBV-infected patients, HBV patients who were resolved their infection spontaneously and healthy volunteers...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181743/clinical-assessment-of-patients-with-acromegaly
#17
Feyzi Gokosmanoglu, Attila Onmez
Background: In this study, we aimed to retrospectively evaluate treatment outcomes and treatment methods in acromegaly patients. Materials and Methods: The study included 65 acromegaly patients followed in Sakarya University Faculty of Medicine Department of Endocrinology in Turkey between 2004 and 2013. Clinical, biochemical, and radiological data were obtained retrospectively from the medical files of the patients. All cases have been discussed in the endocrinology and pituitary surgery council, and a multidisciplinary treatment approach had been chosen in management...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181742/the-complex-effects-of-adipokines-in-the-patients-with-kidney-disease
#18
REVIEW
Sahar Vahdat
Kidney diseases are categorized as the highest prevalent ones with worldwide noticeable incidence. They cause accelerated cardiovascular diseases and noticeable mortalities. Adipose tissue and its messengers, adipokines, are reported to have the highest relationship with end-stage renal diseases or chronic kidney diseases. Over recent years, with shifting of scientists' mindset from a simple overview of adipose tissue as a fat store to the complex paradigm of this issue as a multipotential secretory organ, the importance of studies on this tissue has emerged...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30181741/association-of-a-disintegrin-and-metalloproteinase-with-a-thrombospondin-type-1-motif-member-13-polymorphisms-with-severity-of-coronary-stenosis-in-type-2-diabetes-mellitus
#19
Supakanya Lasom, Nantarat Komanasin, Nongnuch Settasatian, Chatri Settasatian, Upa Kukongviriyapan, Pongsak Intharapetch
Background: The imbalance of von Willebrand factor (vWF) and a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 (ADAMTS13) has been associated with atherosclerosis progression. A high level of vWF which regulates thrombus formation is associated with diabetes mellitus (DM), and some ADAMTS13 and vWF polymorphisms have effects on their levels. Therefore, this study aimed to evaluate the associations of ADAMTS13 and vWF polymorphisms and their levels with DM and severity of coronary stenosis...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30057642/efficacy-of-herbal-combination-of-sedge-saffron-and-astragalus-honey-on-major-neurocognitive-disorder
#20
Shahla Akouchekian, Victoria Omranifard, Mohamad Reza Maracy, Ainour Pedram, Asiyeh Almasi Zefreh
Background: Major neurocognitive disorder (MCD) is an acquired progressive decline in cognitive abilities that causes a drop in specific acquired performance compared to former performances. We tried to investigate the efficacy of herbal combination of sedge, saffron, and Astragalus honey on cognitive and depression score of patients with MCD. Materials and Methods: It was a randomized double-blind clinical trial conducted on sixty patients with MCD, who referred to the geriatric psychiatry clinic of Isfahan University of Medical Sciences in Iran...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
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