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International Journal of Biological Sciences

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https://www.readbyqxmd.com/read/28656005/stroma-derived-fibrinogen-like-protein-2-activates-cancer-associated-fibroblasts-to-promote-tumor-growth-in-lung-cancer
#1
Ying Zhu, Longhui Zhang, Haoran Zha, Fei Yang, Chunyan Hu, Lin Chen, Bo Guo, Bo Zhu
Fibrinogen-like protein 2 (Fgl2), a member of the fibrinogen super family, is a pleiotropic cytokine that impacts diverse cellular functions. Previous studies have shown that tumor cell-derived Fgl2 promotes tumorigenesis and metastasis in immune-deficient mice, and it also functions as an immune-suppressive modulator in glioblastoma multiform (GMB). This study aimed to evaluate whether and how tumor stroma-derived Fgl2 affects tumorigenesis and tumor progression. We established the syngeneic transplantable Lewis lung carcinoma (LLC) model in Fgl2-knock-out (Fgl2-KO) mice and we found that deficiency of host Fgl2 is associated with reduced growth of syngeneic LLC tumors...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28656004/berberine-reverses-hypoxia-induced-chemoresistance-in-breast-cancer-through-the-inhibition-of-ampk-hif-1%C3%AE
#2
Yue Pan, Dan Shao, Yawei Zhao, Fan Zhang, Xiao Zheng, Yongfei Tan, Kan He, Jing Li, Li Chen
Breast cancer is the most common type of cancer and the second leading cause of cancer death in American women. Chemoresistance is common and inevitable after a variable period of time. Therefore, chemosensitization is a necessary strategy on drug-resistant breast cancer. In this study, MCF-7 breast cancer cell was cultured under hypoxia for a week to induce the resistance to doxorubincin (DOX). The effect of different doses of berberine, a traditional Chinese medicine, on DOX sensitivity to MFC-7/hypoxia cells was observed...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28656003/dioscin-induces-gallbladder-cancer-apoptosis-by-inhibiting-ros-mediated-pi3k-akt-signalling
#3
Xiaoling Song, Zheng Wang, Haibin Liang, Wenjie Zhang, Yuanyuan Ye, HuaiFeng Li, Yunping Hu, Yijian Zhang, Hao Weng, Jianhua Lu, Xuefeng Wang, Maolan Li, Yingbin Liu, Jun Gu
Gallbladder cancer (GBC), highly aggressive form of cancer with an extremely poor prognosis, is the most common malignancy of the biliary tract. In this study, we investigated the effects of dioscin (DSN) on human GBC and the potential mechanisms underlying these effects. The results showed that DSN significantly inhibited GBC cell proliferation and migration. Moreover, DSN induced GBC cell apoptosis via mitochondrial dependent apoptotic signalling. Reactive oxygen species (ROS) and glutathione (GSH) levels were measured, and ROS scavengers completely inhibited DSN-induced apoptosis and migration, indicating that ROS play an essential role in GBC progression...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28656002/angiomotin-family-members-oncogenes-or-tumor-suppressors
#4
REVIEW
Meng Lv, Yanwei Shen, Jiao Yang, Shuting Li, Biyuan Wang, Zheling Chen, Pan Li, Peijun Liu, Jin Yang
Angiomotin (Amot) family contains three members: Amot (p80 and p130 isoforms), Amot-like protein 1 (Amotl1), and Amot-like protein 2 (Amotl2). Amot proteins play an important role in tube formation and migration of endothelial cells and the regulation of tight junctions, polarity, and epithelial-mesenchymal transition in epithelial cells. Moreover, these proteins regulate the proliferation and migration of cancer cells. In most cancers, Amot family members promote the proliferation and invasion of cancer cells, including breast cancer, osteosarcoma, colon cancer, prostate cancer, head and neck squamous cell carcinoma, cervical cancer, liver cancer, and renal cell cancer...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28656001/two-olfactory-pathways-to-detect-aldehydes-on-locust-mouthpart
#5
Liwei Zhang, Hongwei Li, Long Zhang
Sensing chemical cues is crucial for insects through their olfactory systems to adapt the environments. The receptors employed in insect olfactory system belong to the Odorant Receptor (ORs) and Ionotropic Receptor (IRs) families. In general, ORs and IRs are present in distinct olfactory sensory neurons and function independently. Here, we present evidence that in locust, the abundant host plant odor Hexanal is detected by both IR- and OR-expressing neurons. Use of the palp opening response (POR) as a simple behavioral paradigm in conjunction with RNA interference (RNAi) revealed that these two pathways are both needed for the detection of Hexanal...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28656000/oncogenic-protein-kinase-d3-regulating-networks-in-invasive-breast-cancer
#6
Yan Liu, Jian Li, Jun Zhang, Zhenghong Yu, Shiyi Yu, Lele Wu, Yuzhi Wang, Xue Gong, Chenxi Wu, Xiuxiu Cai, Lin Mo, Mingya Wang, Jun Gu, Liming Chen
Protein Kinase D3 (PRKD3) functions as an important oncogenic driver in invasive breast cancer, which is the leading cause of women mortality. However, PRKD3 regulating network is largely unknown. In this study, we systematically explored PRKD3 regulating networks via investigating phosphoproteome, interactome and transcriptome to uncover the molecular mechanism of PRKD3 in invasive breast cancer. Using iTRAQ, 270 proteins were identified as PRKD3 regulated phosphoproteins from 4619 phosphosites matching 3666 phosphopeptides from 2016 phosphoproteins with p-value <0...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28655999/genome-wide-identification-and-expression-analysis-of-amino-acid-transporters-in-the-whitefly-bemisia-tabaci-gennadius
#7
Jixing Xia, Zezhong Yang, Cheng Gong, Wen Xie, Huipeng Pan, Zhaojiang Guo, Huixin Zheng, Xin Yang, Xiaodong Sun, Shi Kang, Fengshan Yang, Qingjun Wu, Shaoli Wang, Bin Cong, Xianfeng Teng, Youjun Zhang
The whitefly (Bemisia tabaci) is a cosmopolitan and devastating pest of agricultural crops and ornamentals. B. tabaci causes extensive damage by feeding on phloem and by transmitting plant viruses. Like many other organisms, insects depend on amino acid transporters (AATs) to transport amino acids into and out of its cells. We present a genome-wide and transcriptome-wide investigation of the following two families of AATs in B. tabaci biotype B: amino acid/auxin permease (AAAP) and amino acid/polyamine/organocation (APC)...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28655998/exosomes-from-melatonin-treated-hepatocellularcarcinoma-cells-alter-the-immunosupression-status-through-stat3-pathway-in-macrophages
#8
Liang Cheng, Jiatao Liu, Qingqing Liu, Yu Liu, Lulu Fan, Fang Wang, Hanqing Yu, Yuhuan Li, Lijia Bu, Xiaoqiu Li, Wei Wei, Hua Wang, Guoping Sun
Immunosuppression is a significant factor in the progression of tumor invasion and metastasis. Melatonin, a well-known hormone, has certain cytotoxic and immune regulatory effects to inhibit tumor function. Exosomes are small membrane vesicles released by many kinds of cells, which contain different macromolecules, such as mRNAs and microRNAs (miRNAs), and proteins that can mediate communications between cells. Tumor-derived exosomes may cause immunosuppression, however, it is unknown whether melatonin can attenuate an immunosuppressive status by altering the function of tumor-derived exosomes...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28655997/mechanism-of-ribosome-translation-through-mrna-secondary-structures
#9
REVIEW
Ping Xie, Hong Chen
A ribosome is a macromolecular machine that is responsible for translating the genetic codes in messenger RNA (mRNA) into polypeptide chains. It has been determined that besides translating through the single-stranded region, the ribosome can also translate through the duplex region of mRNA by unwinding the duplex. To understand the mechanism of ribosome translation through the duplex, several models have been proposed to study the dynamics of mRNA unwinding. Here, we present a comprehensive review of these models and also discuss other possible models...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28655996/eupafolin-exhibits-potent-anti-angiogenic-and-antitumor-activity-in-hepatocellular-carcinoma
#10
Honglei Jiang, Dan Wu, Dong Xu, Hao Yu, Zheming Zhao, Dongyan Ma, Junzhe Jin
Eupafolin is a flavonoid extracted from the common sage herb which has been used in China as traditional medicine. Previous studies had reported that eupafolin had antioxidative, anti-inflammatory and antitumor effects. However, the function and the mechanism of eupafolin to exert its antitumor activity, especially its effect on tumor angiogenesis, have not been elucidated. Herein, we showed that eupafolin significantly inhibited vascular endothelial growth factor (VEGF)-induced cell proliferation, migration and tube formation of human umbilical vascular endothelial cells (HUVECs) in a dose-dependent manner...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28655995/microrna-142-3p-and-let-7g-negatively-regulates-augmented-il-6-production-in-neonatal-polymorphonuclear-leukocytes
#11
Hsin-Chun Huang, Hong-Ren Yu, Te-Yao Hsu, I-Lun Chen, Hui-Chen Huang, Jen-Chieh Chang, Kuender D Yang
Neonatal PMN are qualitatively impaired in functions, yet they frequently reveal augmented inflammatory reactions during sepsis. Here, we hypothesized that PMN from newborns produce more IL-6 than those from adults under LPS stimulation, in which transcriptional or posttranscriptional regulation is involved in the altered expression. We found that neonatal PMN produced significantly higher IL-6 mRNA and protein than adult PMN. The higher IL-6 expression was not related to transcriptional but posttranscriptional regulation as the IL-6 expression was affected by the addition of cycloheximide but not actinomycin...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28655994/sleep-duration-and-patterns-in-chinese-older-adults-a-comprehensive-meta-analysis
#12
Li Lu, Shi-Bin Wang, Wen-Wang Rao, Gabor S Ungvari, Chee H Ng, Helen F K Chiu, Juan Zhang, Changgui Kou, Fu-Jun Jia, Yu-Tao Xiang
This meta-analysis examined the mean sleep duration and patterns in Chinese older adult population. A literature search was systematically conducted covering major English (PubMed, Embase and PsycINFO) and Chinese (Chinese National Knowledge Infrastructure (CNKI), WanFang and SinoMed) databases. Data in studies with the mean and standard deviation of sleep duration and/or the proportion of short and long sleep durations in Chinese older adults were extracted and pooled using random-effects models. Subgroup analyses were conducted according to gender, region, area, survey time and sample size...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28539839/ppard-is-an-inhibitor-of-cartilage-growth-in-external-ears
#13
Zhen Zhang, Yanyu Duan, Zhongping Wu, Hui Zhang, Jun Ren, Lusheng Huang
Peroxisome proliferator-activated receptor beta/delta (PPARD) is an important determinant of multiple biological processes. Our previous studies identified a missense mutation in the PPARD gene that significantly reduces its transcription activity, and consequently causes enlarged external ears in pigs. However, the mechanisms underlying the causality has remained largely unknown. Here, we show that PPARD retards the development of auricular cartilage by accelerating the apoptosis of cartilage stem/progenitor cells (CSPCs), the terminal differentiation of cartilage cells and the degradation of cartilage extracellular matrix in the auricle...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28539838/andrographolide-inhibits-angiogenesis-by-inhibiting-the-mir-21-5p-timp3-signaling-pathway
#14
Jianwei Dai, Yuyin Lin, Youfa Duan, Zixuan Li, Dalei Zhou, Wensheng Chen, Lijing Wang, Qian-Qian Zhang
Angiogenesis provides nutrients and oxygen to promote tumor growth and affords a channel that facilitates tumor cell entry into the circulation. Andrographolide (Andro) possess anti-tumor activity; however, its direct effect on angiogenesis still needs to be clarified. In this study, our experiments revealed that Andro significantly inhibited vascular growth in chick embryo chorioallantoic membrane (CAM) and yolk sac membrane (YSM) models. Meanwhile, tumor angiogenesis was also suppressed by Andro. Additionally, we found that cell proliferation, migration and tube formation of vascular endothelial cells was inhibited by Andro treatment in vitro...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28539837/ezh2-acts-as-a-tumor-suppressor-in-kras-driven-lung-adenocarcinoma
#15
Yanxiao Wang, Ning Hou, Xuan Cheng, Jishuai Zhang, Xiaohong Tan, Chong Zhang, Yuling Tang, Yan Teng, Xiao Yang
Previous studies have suggested that enhancer zeste homolog 2 (Ezh2), a histone methyltransferase subunit of polycomb repressive complex 2 (PRC2), acts as an oncogene in lung adenocarcinoma (ADC) development. However, we found that in human lung ADC samples, deletion and mutations of EZH2 were also frequently present, with 14% of patients harboring loss-of-function EZH2 alterations. To explore the effect of Ezh2 loss on lung tumor formation, lung epithelial Ezh2 gene was deleted in Kras-driven lung ADC mouse model...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28539836/dual-delivery-of-ngf-and-bfgf-coacervater-ameliorates-diabetic-peripheral-neuropathy-via-inhibiting-schwann-cells-apoptosis
#16
Rui Li, Jianfeng Ma, Yanqing Wu, Matthew Nangle, Shuang Zou, Yiyang Li, Jiayu Yin, Yingzheng Zhao, Helin Xu, Hongyu Zhang, Xiaokun Li, Qing Song Ye, Jian Wang, Jian Xiao
Diabetic neuropathy is a kind of insidious complications that impairs neural and vascular function and ultimately leads to somatic and visceral denervation. Basic fibroblast growth factor (bFGF) and nerve growth factor (NGF) are important neurotrophic factors for stimulating angiogenesis and improving peripheral nerve function. Administrating a single factor has good therapeutic effect on diabetic peripheral neuropathy (DPN). However, the short half-life and rapid diffusion of growth factors under physiological conditions limits its clinical applications...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28539835/the-myosin-ii-inhibitor-blebbistatin-ameliorates-fecl3-induced-arterial-thrombosis-via-the-gsk3%C3%AE-nf-%C3%AE%C2%BAb-pathway
#17
Yuanyuan Zhang, Long Li, Yazheng Zhao, Han Han, Yang Hu, Di Liang, Boyang Yu, Junping Kou
Arterial thrombosis and its related diseases are major healthcare problems worldwide. Blebbistatin is an inhibitor of myosin II, which plays an important role in thrombosis. The aim of our study is to explore the effect and potential mechanism of blebbistatin on arterial thrombosis. A ferric chloride (FeCl3) solution at a concentration of 5% was used to induce carotid artery thrombosis in mice. Immunohistochemistry and immunofluorescence staining were used to detect the expression or activation of non-muscle myosin heavy chain IIA (NMMHC IIA), tissue factor (TF), GSK3β and NF-κB...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28539834/complex-relationship-between-obesity-and-the-fat-mass-and-obesity-locus
#18
REVIEW
Qingyun Yang, Tiancun Xiao, Jiao Guo, Zhengquan Su
In the 21st century, obesity has become a serious problem because of increasing obese patients and numerous metabolic complications. The primary reasons for this situation are environmental and genetic factors. In 2007, FTO (fat mass and obesity associated) was the first gene identified through a genome-wide association study (GWAS) associated with obesity in humans. Subsequently, a cluster of single nucleotide polymorphisms (SNPs) in the first intron of the FTO gene was discovered to be associated with BMI and body composition...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28539833/sdf-1-in-mammary-fibroblasts-of-bovine-with-mastitis-induces-emt-and-inflammatory-response-of-epithelial-cells
#19
Guiliang He, Mengru Ma, Wei Yang, Hao Wang, Yong Zhang, Ming-Qing Gao
Fibroblasts constitute the majority of the stromal cells within bovine mammary gland, yet the functional contributions of these cells to mastitis and fibrosis and the mechanism are poorly understood. In this study, we demonstrate that inflammation-associated fibroblasts (INFs) extracted from bovine mammary glands with clinical mastitis had different expression pattern regarding to several extracellular matrix (ECM) proteins, chemokines and cytokines compared to normal fibroblasts (NFs) from dairy cows during lactation...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28539832/recapitulating-and-correcting-marfan-syndrome-in-a-cellular-model
#20
Jung Woo Park, Li Yan, Chris Stoddard, Xiaofang Wang, Zhichao Yue, Leann Crandall, Tiwanna Robinson, Yuxiao Chang, Kyle Denton, Enqin Li, Bin Jiang, Zhenwu Zhang, Kristen Martins-Taylor, Siu-Pok Yee, Hong Nie, Feng Gu, Wei Si, Ting Xie, Lixia Yue, Ren-He Xu
Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in FBN1 gene, which encodes a key extracellular matrix protein FIBRILLIN-1. The haplosufficiency of FBN1 has been implicated in pathogenesis of MFS with manifestations primarily in cardiovascular, muscular, and ocular tissues. Due to limitations in animal models to study the late-onset diseases, human pluripotent stem cells (PSCs) offer a homogeneic tool for dissection of cellular and molecular pathogenic mechanism for MFS in vitro. Here, we first derived induced PSCs (iPSCs) from a MFS patient with a FBN1 mutation and corrected the mutation, thereby generating an isogenic "gain-of-function" control cells for the parental MFS iPSCs...
2017: International Journal of Biological Sciences
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