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International Journal of Biological Sciences

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https://www.readbyqxmd.com/read/30123084/a-novel-fgfr1-binding-peptide-exhibits-anti-tumor-effect-on-lung-cancer-by-inhibiting-proliferation-and-angiogenesis
#1
Qiaoyan Tan, Zuqiang Wang, Quan Wang, Yuanqiang Wang, Zhifeng Huang, Nan Su, Min Jin, Liang Kuang, Huabing Qi, Zhenhong Ni, Can Li, Ying Zhu, Wanling Jiang, Hangang Chen, Chuxia Deng, Xiaolan Du, Yangli Xie, Lin Chen
It has been reported that overactivation of fibroblast growth factor receptor 1 (FGFR1 ) is an important characteristic found in most non-small cell lung cancer (NSCLC) samples. Here, we identified a FGFR1 inhibitory peptide R1-P2 and investigated its effects on the lung cancer cells growth and angiogenesis in vitro and in vivo . Our results demonstrate that R1-P2 bound to human FGFR1 protein, and efficiently blocked the binding of FGF2 to FGFR1 in A549 and NCI-H460 cells. Moreover, this peptide significantly decreased the proliferation, migration and invasion, but promoted the apoptosis in both cell lines...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123083/-antrodia-cinnamomea-galactomannan-elicits-immuno-stimulatory-activity-through-toll-like-receptor-4
#2
Namal Perera, Feng-Ling Yang, Yueh-Tung Lu, Lan-Hui Li, Kuo-Feng Hua, Shih-Hsiung Wu
Antrodia cinnamomea ( A. cinnamomea ) is a medicinal fungus used in traditional Chinese medicine to treat different kinds of ailments, including liver diseases, abdominal pain, drug intoxication, diarrhea, itchy skin, hypertension, and cancer. Polysaccharides have been identified as one of the major pharmacologically active ingredients present in A. cinnamomea . The present study aims to investigate the immunoenhancing activity of galactomannan isolated from A. cinnamomea . The cold water-soluble polysaccharide (galactomannan-repeated; MW>70 kDa; named ACP) of A...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123082/construction-of-implantation-failure-related-lncrna-mrna-network-and-identification-of-lncrna-biomarkers-for-predicting-endometrial-receptivity
#3
Chun Feng, Jin-Ming Shen, Ping-Ping Lv, Min Jin, Li-Quan Wang, Jin-Peng Rao, Lei Feng
Insufficient endometrial receptivity is a major factor leading to implantation failure (IF), and the traditional way of morphological observation of endometrium cannot determine the condition of receptivity sufficiently. Considering that long-noncoding RNAs (lncRNAs) regulate endometrial receptivity and competing endogenous RNA (ceRNA) mechanism works in plenty of biological processes, ceRNA is likely to function in the pathology of IF. In the present study, we aim to construct an implantation failure related lncRNA-mRNA network (IFLMN), and to identify the key lncRNAs as the candidates for predicting endometrial receptivity...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123081/neutrophil-elastase-inhibitors-and-chronic-kidney-disease
#4
REVIEW
Elsa Bronze-da-Rocha, Alice Santos-Silva
End-stage renal disease (ESRD), the last stage of chronic kidney disease (CKD), is characterized by chronic inflammation and oxidative stress. Neutrophils are the front line cells that mediate an inflammatory response against microorganisms as they can migrate, produce reactive oxygen species (ROS), secrete neutrophil serine proteases (NSPs), and release neutrophil extracellular traps (NETs). Serine proteases inhibitors regulate the activity of serine proteases and reduce neutrophil accumulation at inflammatory sites...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123080/expression-of-vegfr-3-in-intrahepatic-cholangiocarcinoma-correlates-with-unfavorable-prognosis-through-lymphangiogenesis
#5
Meng Sha, Seogsong Jeong, Xiao-Song Chen, Ying Tong, Jie Cao, Han-Yong Sun, Lei Xia, Ning Xu, Xin Wang, Long-Zhi Han, Zhi-Feng Xi, Jian-Jun Zhang, Xiao-Ni Kong, Qiang Xia
Background & aims: VEGFR-3 has been shown of great significance in lymph node metastasis and some malignancies, however, its expression in tumors and impact on outcome of intrahepatic cholangiocarcinoma (iCCA) remains unknown. The aim of this study was to assess the role of VEGFR-3 positive tumors for prognosis of iCCA and tumor-associated lymphangiogenesis. Methods: Clinicopathological features, prognostic factors and survival rate were analyzed to evaluate the influence of VEGFR-3 positive expression on prognosis of iCCA...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123079/genome-wide-identification-and-characterization-of-enhancers-across-10-human-tissues
#6
Lili Xiong, Ran Kang, Ruofan Ding, Wenyuan Kang, Yiming Zhang, Wenrong Liu, Qingqing Huang, Junhua Meng, Zhiyun Guo
Background: Enhancers can act as cis-regulatory elements (CREs) to control development and cellular function by regulating gene expression in a tissue-specific and ubiquitous manner. However, the regulatory network and characteristic of different types of enhancers (e.g., transcribed/non-transcribed enhancers, tissue-specific/ubiquitous enhancers) across multiple tissues are still unclear. Results: Here, a total of 53,924 active enhancers and 10,307 enhancer-associated RNAs (eRNAs) in 10 tissues (adrenal, brain, breast, heart, liver, lung, ovary, placenta, skeletal muscle and kidney) were identified through the integration of histone modifications (H3K4me1, H3K27ac and H3K4me3) and DNase I hypersensitive sites (DHSs) data...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123078/preliminary-observation-about-alteration-of-proteins-and-their-potential-functions-in-spinal-cord-of-sod1-g93a-transgenic-mice
#7
Jie Zhang, Ping Huang, Chengsi Wu, Huiting Liang, Yue Li, Lei Zhu, Yi Lu, Chunyan Tang, Renshi Xu
The protein abnormality participates in the development of ALS that meets with the widespread approval from major researchers. However, these currently found abnormal proteins aren't far enough to explain all pathogenesis of ALS. Therefore, the search of novel abnormal proteins participated in the pathogenesis of ALS is very necessary. In this study, we screened, compared and analyzed the differentially expressed proteins in the spinal cord of the SOD1 G93A transgenic and wild-type (WT) mice applying the isobaric tags for relative and absolute quantitation (iTRAQ) and the bioinformatics methods...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123077/combined-inhibition-of-autophagy-and-nrf2-signaling-augments-bortezomib-induced-apoptosis-by-increasing-ros-production-and-er-stress-in-pancreatic-cancer-cells
#8
Xu Li, Meng Liang, Jianxin Jiang, Ruizhi He, Min Wang, Xingjun Guo, Ming Shen, Renyi Qin
Pancreatic cancer (PC) is highly resistant to current therapies; thus, there is an urgent need to develop new treatment strategies. The proteasome is crucially important for proteostasis, which is involved in cell proliferation and survival, making it an attractive therapeutic target in cancer. However, recent studies have indicated that bortezomib, a highly selective proteasome inhibitor, has limited effects in solid tumors including PC. Thus, more mechanistic insights into chemo-sensitization strategies for bortezomib are urgently needed...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123076/fluid-shear-stress-promotes-autophagy-in-hepatocellular-carcinoma-cells
#9
Xiaoli Wang, Yingying Zhang, Tang Feng, Guanyue Su, Jia He, Wenbo Gao, Yang Shen, Xiaoheng Liu
The autophagy in cancer cells is recognized as an essential hallmark of tumors, which can enhance cancer cell migration and invasion, and result in high incidence of tumor metastasis. The fluid shear stress (FSS) in tumor mechanical microenvironment plays a pivotal role in mediating the behaviors and functions of cells. In this study, the hepatocellular carcinoma cells were exposed to 1.4 dyn/cm2 FSS to explore whether FSS could induce autophagy. The results of TEM, Ad-mCherry-GFP labeled LC3B, and mRNA and protein expression of autophagy markers confirmed that FSS could induce autophagy in a time-dependent manner...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123075/enhancer-rna-p2ry2e-induced-by-estrogen-promotes-malignant-behaviors-of-bladder-cancer
#10
Mengting Ding, Hengji Zhan, Xinhui Liao, Aolin Li, Yucheng Zhong, Qunjun Gao, Yuchen Liu, Weiren Huang, Zhiming Cai
Enhancers are transcriptional regulatory elements that increase target gene expression. It has reported that enhancers could universally transcribe into enhancer RNAs (eRNAs) with stimulation. Increasing evidence showed eRNAs participated in various disease processes including malignant tumors. P2RY2 enhancer RNA (P2RY2e) is an estrogen-responsive eRNA and involved in the development of breast cancer. However, the relationship between P2RY2e and bladder cancer (BCa) is unclear. In the study, we discovered that P2RY2e was upregulated in BCa tissues and estrogen-treated cells...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123074/timmdc1-knockdown-inhibits-growth-and-metastasis-of-gastric-cancer-cells-through-metabolic-inhibition-and-akt-gsk3%C3%AE-%C3%AE-catenin-signaling-pathway
#11
Yuan Liu, Yuyan Huang, Jingjing Zhang, Cao Pei, Jiahui Hu, Jianxin Lyu, Yao Shen
TIMMDC1 (C3orf1), a predicted 4-pass membrane protein, which locates in the mitochondrial inner membrane, has been demonstrated to have association with multiple member of mitochondrial complex I assembly factors and core mitochondrial complex I subunits. The expression level of TIMMDC1 in highly-metastatic tumor cells is higher than that in lowly- metastatic tumor cells. However, the role of TIMMDC1 in human gastric cancer progression is unclear. In this study, human gastric cancer cells SGC-7901 and BGC-823 cells were used, and TIMMDC1 was knockdown with small interfering RNA...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123073/alcohol-accumulation-promotes-esophagitis-via-pyroptosis-activation
#12
Fengjiao Wang, Gang Li, Jinfeng Ning, Lantao Chen, Hai Xu, Xianglong Kong, Jianlong Bu, Weiwei Zhao, Zhengtian Li, Xiuyun Wang, Xiaoguang Li, Jianqun Ma
Gastroesophageal reflux impairs the mucosal barrier in the distal esophagus, allowing chronic exposure of the squamous epithelium to multitudinous stimulations and inducing chronic inflammation. Esophagitis is a response to inflammation of the esophageal squamous mucosa. Our study clarified that alcohol accumulation could aggravate the progress of esophagitis by inducing pyroptosis; however, Ac-YVAD-CMK, an inhibitor of caspase-1, could effectively suppress the expression of IL-1β and IL-18 both in vivo and in vitro , reducing the inflammatory response, which is promised to be an agent to inhibit the progression of esophagitis...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123072/review-of-drug-repositioning-approaches-and-resources
#13
REVIEW
Hanqing Xue, Jie Li, Haozhe Xie, Yadong Wang
Drug discovery is a time-consuming, high-investment, and high-risk process in traditional drug development. Drug repositioning has become a popular strategy in recent years. Different from traditional drug development strategies, the strategy is efficient, economical and riskless. There are usually three kinds of approaches: computational approaches, biological experimental approaches, and mixed approaches, all of which are widely used in drug repositioning. In this paper, we reviewed computational approaches and highlighted their characteristics to provide references for researchers to develop more powerful approaches...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123071/simultaneously-targeting-dna-damage-repair-pathway-and-mtorc1-2-results-in-small-cell-lung-cancer-growth-arrest-via-er-stress-induced-apoptosis
#14
Bin Fang, Aarthi Kannan, Tao Guo, Ling Gao
Purpose: Small cell lung cancer (SCLC) is highly lethal with no effective therapy. Wee1 kinase inhibitor AZD1775 (MK-1775) and mTOR kinase inhibitor MLN0128 (TAK228) are in clinical trials for relapsed SCLC and recurrent lung cancer, respectively. However, there is no preclinical data combining these two drugs in human cancers. Methods: In this study, we set to investigate the combinatorial anti-tumor effects of AZD1775 and MLN0128 on two human SCLC cell lines H69 and H82 in vitro and in vivo. Results: We have found that AZD1775 or MLN0128 treatment results in remarkably suppressed cell proliferation and increased cell death in vitro, what's more, the salient finding here is the potent anti-tumor effect observed in combinatorial treatment in H82 xenograft tumor...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123070/adapted-hcv-jfh1-variant-is-capable-of-accommodating-a-large-foreign-gene-insert-and-allows-lower-level-hcv-replication-and-viral-production
#15
Qi Wang, Curt Hagedorn, Shuanghu Liu
Infectious HCV carrying reporter genes have further applications in understanding the HCV life cycle including replication, viral assembly and release. In this study, a full-length 3039bp LacZ gene was inserted into the derivative of JFH1-AM120 to develop an additional reporter virus. The results showed that the recombinant reporter virus JFH1-AM120-LacZ can replicate and produce lower titers of infectious virus. However, insertion of the LacZ gene in the C-terminal region of the NS5A in HCV JFH1-AM120-LacZ decreased viral replication and dramatically impaired the production of infectious viral particles...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123069/scalable-generation-of-mesenchymal-stem-cells-from-human-embryonic-stem-cells-in-3d
#16
Li Yan, Bin Jiang, Enqin Li, Xiaoyan Wang, Qinjie Ling, Dejin Zheng, Jung Woo Park, Xin Chen, Edwin Cheung, Xin Du, Yingcui Li, Gregory Cheng, Erxing He, Ren-He Xu
Human embryonic stem cell (hESC) derived mesenchymal stem cells (EMSC) are efficacious in treating a series of autoimmune, inflammatory, and degenerative diseases in animal models. However, all the EMSC derivation methods reported so far rely on two-dimensional (2D) culture systems, which are inefficient, costive and difficult for large-scale production. HESC, as an unlimited source, can be successively propagated in spheroids. Here, we demonstrate that hESC spheroids can directly differentiate into MSC spheroids (EMSCSp ) within 20 days in one vessel without passaging and the system is scalable to any desired size...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123068/hepatic-ischemic-preconditioning-alleviates-ischemia-reperfusion-injury-by-decreasing-tim4-expression
#17
Yu Zhang, Qiang Shen, Yuanxing Liu, Hui Chen, Xiaoxiao Zheng, Shangzhi Xie, Haofeng Ji, Shusen Zheng
Ischemia-reperfusion injury (IRI) of the liver is a primary cause of post-liver-surgery complications and ischemic preconditioning (IPC) has been verified to protect against ischemia-reperfusion injury. TIM-4 activation plays an important role in macrophage mediated hepatic IRI. This study aimed to determine whether IPC protects against hepatic IRI through inhibiting TIM-4 activation. In this study, a model of warm liver ischemia (90 min) and reperfusion for 6 h was used. Mice were subjected to ischemia-reperfusion injury with or without ischemic preconditioning and TIM4 blocking antibody...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123067/astemizole-inhibits-mtor-signaling-and-angiogenesis-by-blocking-cholesterol-trafficking
#18
Junfang Lyu, Eun Ju Yang, Sarah A Head, Nana Ai, Baoyuan Zhang, Changjie Wu, Ruo-Jing Li, Yifan Liu, Harapriya Chakravarty, Shaolin Zhang, Kin Yip Tam, Yongjun Dang, Ho Jeong Kwon, Wei Ge, Jun O Liu, Joong Sup Shim
Cholesterol plays a key role in membrane protein function and signaling in endothelial cells. Thus, disturbing cholesterol trafficking is an effective approach for inhibiting angiogenesis. We recently identified astemizole (AST), an antihistamine drug, as a cholesterol trafficking inhibitor from a phenotypic screen. In this study, we found that AST induced cholesterol accumulation in the lysosome by binding to the sterol-sensing domain of Niemann-Pick disease, type C1 (NPC1), a lysosomal surface protein responsible for cholesterol transport...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123066/topical-application-of-tat-rac1-promotes-cutaneous-wound-healing-in-normal-and-diabetic-mice
#19
Bin Fan, Tao Wang, Li Bian, Zhe Jian, Dongyan D Wang, Fulun Li, Fanglong Wu, Tao Bai, Gongyi Zhang, Nik Muller, Barry Holwerda, Gangwen Han, Xiao-Jing Wang
The endogenous small GTPase, Rac1, plays a critical role during normal skin wound healing. It remains to be determined whether endogenous Rac1 can be appropriately activated in chronic wounds; if not, whether exogenous Rac1 has therapeutic effects on wound healing. Here we show that Rac1 protein levels were lower in wounds of db/db diabetic mice than wounds in wild type mice during the healing process. To assess the therapeutic potential of exogenous Rac1 in wound healing, we produced a Tat-Rac1 fusion protein that enters into cells through protein transduction...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/30123065/combined-effects-of-pvt1-and-mir-146a-single-nucleotide-polymorphism-on-the-lung-function-of-smokers-with-chronic-obstructive-pulmonary-disease
#20
Sijing Zhou, Yi Liu, Min Li, Peipei Wu, Gengyun Sun, Guanghe Fei, Xuan Xu, Xuexin Zhou, Luqian Zhou, Ran Wang
Non-coding RNAs play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study was performed to investigate the role of PVT1 and miR-146a single nucleotide polymorphisms (SNPs) in the lung function of COPD smokers. Real-time PCR and Western blot analyses were performed to measure the expression of miR-146 and PVT1 SNPs and determine the effect of these SNPs on the pathogenesis of COPD. A total of 100 COPD smokers were enrolled in this study and divided into four groups as follows: Rs2910164CC/GC + Rs13281615GG; Rs2910164CC/GC + Rs13281615GA/AA; Rs2910164GG + Rs13281615GG; and Rs2910164GG + Rs13281615GA/AA...
2018: International Journal of Biological Sciences
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