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International Journal of Biological Sciences

Yuan Liu, Lu Gao, Xiaoyan Zhao, Sen Guo, Yuzhou Liu, Ran Li, Cui Liang, Ling Li, Jianzeng Dong, Lina Li, Haibo Yang
Saikosaponin A (SSA) is a triterpenoid saponin with many pharmacological activities, including anti-inflammatory and antioxidant effects. The effect of SSA on cardiac remodeling and fibrosis, however, remains unclear. Aortic banding surgery was used to establish a mouse cardiac remodeling and fibrosis model. Mice were subjected to an intraperitoneal (i.p.) injection of SSA (5 mg/kg/d or 40 mg/kg/d) 2 weeks after surgery for 28 days. As a result, SSA had limited effect on cardiac hypertrophy but decreased cardiac fibrosis remarkably...
2018: International Journal of Biological Sciences
Bo Hou, Zhuopeng Ye, Wanqing Ji, Meiqin Cai, Cong Ling, Chuan Chen, Ying Guo
Schwann cells (SCs) are primarily responsible for the formation of myelin sheaths, yet bone marrow mesenchymal stem cell (BMSC)-derived SCs are often used to replace autologous SCs and assist with the repair of peripheral nerve myelin sheaths. In this study, the effects of the two cell types on remyelination were compared during the repair of peripheral nerves. Methods: An acellular nerve scaffold was prepared using the extraction technique. Rat BMSCs and autologous SCs were extracted. BMSCs were induced to differentiate into BMSC-derived SCs (B-dSCs) in vitro...
2018: International Journal of Biological Sciences
Enqin Li, Zhenwu Zhang, Bin Jiang, Li Yan, Jung Woo Park, Ren-He Xu
Mesenchymal stem cells (MSC) have been derived from a variety of tissues, and cultured either in animal serum-containing (SC) or serum-free (SF) media. We have previously derived MSC from human embryonic stem cells via an intermediate trophoblast step (named EMSC), which also have immunosuppressive and therapeutic effects on animal models of autoimmune disease. To promote the clinical application of this new source of MSC, we report here EMSC derived and cultured in a SF medium MesenCult (SF-EMSC) in comparison with a SC medium (SC-EMSC)...
2018: International Journal of Biological Sciences
Min Xu, Hailong Wu, Meng Li, Yankai Wen, Chang Yu, Lei Xia, Qiang Xia, Xiaoni Kong
Our previous studies have shown that DJ-1 play important roles in progression of liver diseases through modulating hepatic ROS production and immune response, but its role in hepatic steatosis remains obscure. In the present study, by adopting a high-fat-diet (HFD) induced mice model, we found that DJ-1 knockout (DJ-1 -/- ) mice showing decreased HFD-induced obesity and visceral adipose accumulation. In line with these changes, there were also reduced liver weight and ameliorated hepatic triglyceride (TG) accumulation in DJ-1-/- mice compared to wild-type (WT) mice...
2018: International Journal of Biological Sciences
Yonggang Wang, Fangshi Hao, Yonghao Nan, Licheng Qu, Wanli Na, Chunshu Jia, Xiaoliang Chen
Cisplatin-based chemotherapy often results in the development of chemo-resistance when used to treat bladder cancer (BC), which is difficult to overcome. Recent data indicate that pyruvate kinase M2 (PKM2), a glycolytic enzyme for Warburg effect, is strongly upregulated in BC, and contributes to the cisplatin resistance in BC. However, the underlying mechanisms remain unclear. In this study, we also found that the expression level of PKM2 is also higher in cisplatin resistant BC cells and tumors. Down-regulation of PKM2 by siRNA or inhibition of PKM2 by shikonin re-sensitized the cisplatin resistant T24 cells...
2018: International Journal of Biological Sciences
Jianle Wang, Ke Wang, Chongan Huang, Dongdong Lin, Yifei Zhou, Yaosen Wu, Naifeng Tian, Pei Fan, Xiangxiang Pan, Daoliang Xu, Jianing Hu, Ying Zhou, Xiangyang Wang, Xiaolei Zhang
Mitochondrial dysfunction is an important contributor to the development of osteoarthritis (OA). Sirtuin 3 (SIRT3) regulates diverse mitochondrial proteins to maintain mitochondrial homeostasis, and dihydromyricetin (DHM) is reported as a potential SIRT3 activator. This study aims to explore the relevance of SIRT3 and OA, as well as the therapeutic effects of DHM on mitochondrial homeostasis in TNF-α-treated chondrocytes. The relationship between SIRT3 and OA was confirmed by detecting SIRT3 level in vitro and in vivo ...
2018: International Journal of Biological Sciences
Ying Mei, Yong-Bin Liu, Dong-Li Hu, Hong-Hao Zhou
Platinum-based chemotherapy is used as first-line therapy for advanced non-small-cell lung cancer (NSCLC). However, there is no effective indicator to predict whether the patient would be chemo-resistant or sensitive to the therapy. In addition, it is urgent to elucidate the mechanisms of cisplatin resistance. RIF1 plays important roles in DNA replication regulation and DNA repair pathway. However, the role of RIF1 in NSCLC progression and chemotherapy response is still unknown. In this study, we found that RIF1 expression was correlated with the response of NSCLC patients to platinum-based chemotherapy (n=89, P=0...
2018: International Journal of Biological Sciences
Bin He, Longfei Dai, Xiaoqian Zhang, Diyu Chen, Jingbang Wu, Xiaode Feng, Yanpeng Zhang, Haiyang Xie, Lin Zhou, Jian Wu, Shusen Zheng
The high activity of Histone deacetylases (HDACs) in hepatocellular carcinoma (HCC) usually positively correlates with poor prognosis of patients. Accordingly histone deacetylases inhibitors (HDACis) are considered to be potential agents treating patients with HCC. In our study, we evaluated effect of quisinostat alone and in combination with sorafenib in HCC cells via inducing G0/G1 phase arrest through PI3K/AKT/p21 pathway and apoptosis by JNK/c-Jun/caspase3 pathway in vitro and in vivo. The proliferation assay and flow cytometry were used to measure the viability, cell cycle and apoptosis...
2018: International Journal of Biological Sciences
Cai-Hong Zhang, Ye Wang, Qian-Qian Sun, Lei-Lei Xia, Jing-Jing Hu, Kai Cheng, Xia Wang, Xin-Xin Fu, Hang Gu
Copper nanoparticles (Cu-NPs) and other inorganic nanomaterials have caused increasing concern owing to be widely used. Early studies have reported that they can result in injuries to the kidney, liver and spleen of mice; cause embryonic damage; and inhibit the reproductive capacity of red worms. However, few studies have reported the toxicity of Cu-NPs on the reproductive systems of mammals. In the present work, we explored the cytotoxicity of Cu-NPs in human extravillous trophoblast cells and in the reproductive organs of mice...
2018: International Journal of Biological Sciences
Jin Deng, Wei Kong, Shuaiqun Wang, Xiaoyang Mou, Weiming Zeng
MRNA and lncRNA serve as a type of endogenous RNA in cell, which can competitively bind to the same miRNA through miRNA response elements (MREs), thereby regulating their respective expression levels, playing an important role in post-transcriptional regulation, and regulating the progress of tumors. The proposed competing endogenous RNA (ceRNA) hypothesis provides novel clues for the occurrence and development of tumors, but the integrative analysis methods of diverse RNA data are significantly limited. In order to find out the relationship among miRNA, mRNA and lncRNA, the previous studies only used individual dataset as seeds to search two other related data in the database to construct ceRNA network, but it was difficult to identify the synchronized effects from multiple regulatory levels...
2018: International Journal of Biological Sciences
Shulin Chen, Xiaohui Li, Hui Lv, Xiaoyan Wen, Qiuying Ding, Ning Xue, Hongkai Su, Hao Chen
Chronic inflammation plays an important role in tumor progression. The aim of this study was to develop an effective predictive dynamic nomogram integrated with inflammation-based factors to predict overall survival (OS) of non-small cell lung cancer (NSCLC) patients with chronic hepatitis B viral (HBV) infection. We retrospectively analyzed NSCLC patients with HBV infection from Sun Yat-sen University Cancer Center between 2008 and 2010. Univariate and multivariate Cox survival analyses were performed to identify prognostic factors associated with OS of patients...
2018: International Journal of Biological Sciences
Xixi Dou, Lichan Chen, Mingjuan Lei, Lucas Zellmer, Qingwen Jia, Peixue Ling, Yan He, Wenxiu Yang, Dezhong Joshua Liao
Organisms and their different component levels, whether organelle, cellular or other, come by birth and go by death, and the deaths are often balanced by new births. Evolution on the one hand has built demise program(s) in cells of organisms but on the other hand has established external controls on the program(s). For instance, evolution has established death program(s) in animal cells so that the cells can, when it is needed, commit apoptosis or senescent death (SD) in physiological situations and stress-induced cell death (SICD) in pathological situations...
2018: International Journal of Biological Sciences
Rui Wang, Hongbo Bao, Shihua Zhang, Ruiyan Li, Lijie Chen, Yulan Zhu
In recent years, accumulating evidence has revealed that microRNAs play critical roles in ischemia stroke. This study was designed to investigate the expression level and effects of microRNA (miR)-186-5p on ischemia stroke, and its underlying molecular mechanism. Firstly, we demonstrated that miR-186-5p were significantly up-regulated and induced apoptosis in oxygen and glucose deprivation/reperfusion (OGD/R) model. Moreover, we found that miR-186-5p reduced the expression of insulin-like growth factor (IGF)-1, an essential factor for the development of the nervous system...
2018: International Journal of Biological Sciences
Allal Ouhtit, Balsam Rizeq, Haissam Abou Saleh, Md Mizanur Rahman, Hatem Zayed
CD44, also known as homing cell adhesion molecule is a multi-structural cell molecule involved in cell-cell and cell-extracellular matrix communications. CD44 regulates a number of central signaling pathways, including PI3K/AKT, Rho GTPases and the Ras-MAPK pathways, but also acts as a growth/arrest sensor, and inhibitor of angiogenesis and invasion, in response to signals from the microenvironment. The function of CD44 has been very controversial since it acts as both, a suppressor and a promoter of tumor growth and progression...
2018: International Journal of Biological Sciences
Hye Jung Baek, Sun Eui Kim, Jong Kwang Kim, Dong Hoon Shin, Tae Hyun Kim, Kwang Gi Kim, Chu-Xia Deng, Sang Soo Kim
Despite the high incidence of BRCA1 -mutant breast cancer, few substantial improvements in preventing or treating such cancers have been made. Using a Brca1 -mutant mouse model, we examined the contribution of AKT to the incidence and growth of Brca1 -mutated mammary tumors. A haploinsufficiency of Akt1 in Brca1 -mutant mouse model significantly decreased mammary tumor formation from 54% in Brca1co/co MMTV-Cre mice to 22% in Brca1 co/co MMTV-Cre Akt1+/- mice. Notably, treatment of tumor-bearing Brca1 -mutant mice with the AKT-inhibitor, MK-2206, yielded partial response or stable disease up to 91% of mice in maximum response...
2018: International Journal of Biological Sciences
Hye Jung Baek, Sun Eui Kim, Eun Kyung Choi, Jong Kwang Kim, Dong Hoon Shin, Eun Jung Park, Tae Hyun Kim, Joo-Young Kim, Kwang Gi Kim, Chu-Xia Deng, Sang Soo Kim
BRCA1-deficient breast cancer is a very well-known hereditary cancer. However, except for resection of normal mammary glands and ovaries, there is no acceptable measure for proactively preventing tumor development. Importantly, inherited BRCA1 mutations are closely associated with tumors in hormone-responsive tissues. Here, we examined the effects of estrogen on the accumulation of genetic instabilities upon loss of BRCA1 , and assessed the contribution of estrogen signaling to the incidence and progression of Brca1 -mutated mammary tumors...
2018: International Journal of Biological Sciences
Haitao Wang, Uma Gaur, Jiao Xiao, Bingtian Xu, Jiangping Xu, Wenhua Zheng
Sensorimotor recovery following ischemic stroke is highly related with structural modification and functional reorganization of residual brain tissues. Manipulations, such as treatment with small molecules, have been shown to enhance the synaptic plasticity and contribute to the recovery. Activation of the cAMP/CREB pathway is one of the pivotal approaches stimulating neuroplasticity. Phosphodiesterase 4 (PDE4) is a major enzyme controlling the hydrolysis of cAMP in the brain. Accumulating evidences have shown that inhibition of PDE4 is beneficial for the functional recovery after cerebral ischemia; i...
2018: International Journal of Biological Sciences
Xiaodong Wen, Xun Chen, Xiaojun Liang, Hongmou Zhao, Yi Li, Xiangxiang Sun, Jun Lu
The activation of TNF-α/NF-кB signaling is involved in the regulation of a wide range of biological processes, such as cell proliferation, differentiation and apoptosis, eventually causing a number of diseases, such as cancer and inflammation. Here, we found that TNF-α/NF-кB signaling was activated in a large number of blood samples taken from foot and ankle rheumatoid arthritis (RA) patients. By applying a microarray assay to the human synovial sarcoma cell line SW982 and the human fibroblast-like synoviocyte cell line HFLS-RA, as well as in their corresponding p65 knockdown and -overexpressing cells, we identified and verified the activation of many p65 targets, including cytokines (e...
2018: International Journal of Biological Sciences
Jianming Zeng, Gang Li
Background: Next-generation sequencing coupled to chromatin immunoprecipitation (ChIP-seq), DNase I hypersensitivity (DNase-seq) and the transposase-accessible chromatin assay (ATAC-seq) has generated enormous amounts of data, markedly improved our understanding of the transcriptional and epigenetic control of gene expression. To take advantage of the availability of such datasets and provide clues on what factors, including transcription factors, epigenetic regulators and histone modifications, potentially regulates the expression of a gene of interest, a tool for simultaneous queries of multiple datasets using symbols or genomic coordinates as search terms is needed...
2018: International Journal of Biological Sciences
Chong Zhang, Yajing Hao, Yanxiao Wang, Jiaqian Xu, Yan Teng, Xiao Yang
Lung cancer is the leading cause of cancer related deaths worldwide. TGF-β-induced epithelial-mesenchymal transition (EMT) is a key cell-intrinsic identity for tumor cell migration, invasion, and stemness acquisition in cancer metastasis. Long noncoding RNAs (lncRNAs) have not been fully investigated for their involvement in regulating TGF-β-induced EMT and metastasis in lung cancer. Here, we demonstrated that the transcription of lncRNA in nonhomologous end joining (NHEJ) pathway 1 (LINP1) was inhibited by TGF-β1 in a SMAD4-dependent manner...
2018: International Journal of Biological Sciences
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