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International Journal of Biological Sciences

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https://www.readbyqxmd.com/read/28367103/novel-approaches-to-vitiligo-treatment-via-modulation-of-mtor-and-nf-%C3%AE%C2%BAb-pathways-in-human-skin-melanocytes
#1
Jerry Wan, Fuquan Lin, Wei Zhang, Aie Xu, Joseph DeGiorgis, Hongguang Lu, Yinsheng Wan
Vitiligo is a skin depigmentation disorder with an increasing prevalence. Among recognized mechanisms is the oxidative stress that affects melanocytes which are responsible for skin pigmentation. Studies have shown that high concentration of hydrogen peroxide, or H2O2, induces apoptotic activities. Few studies have been done with lower doses of H2O2. Using human skin melanocytes, we investigated the effect of moderate concentration of H2O2 on melanocyte dendrites. Confocal data show that H2O2 at 250 µM induces loss of dendrites, as indicated by cytoskeletal proteins...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28367102/inhibition-of-proteasome-activity-induces-aggregation-of-ifit2-in-the-centrosome-and-enhances-ifit2-induced-cell-apoptosis
#2
Limin Chen, Shuyuan Liu, Fen Xu, Yunyuan Kong, Lagen Wan, Yonglu Zhang, Zhanglin Zhang
IFN-induced protein with tetratricopeptide repeats 2 (IFIT2), one of the most highly responsive interferon-stimulated genes, inhibits the proliferation and migration of cancer cells and regulates viral replication. IFIT2 has been demonstrated to be a cytoskeleton-associated protein that becomes enriched in the mitotic spindle of cells. However, the molecular mechanisms by which IFIT2 executes biological functions are largely unclear. The findings of this study showed that inhibiting the activation of proteasome led to the enrichment of IFIT2 and induced the aggregation of IFIT2 protein in the centrosome...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28367101/comparative-mitogenomic-analyses-of-praying-mantises-dictyoptera-mantodea-origin-and-evolution-of-unusual-intergenic-gaps
#3
Hong-Li Zhang, Fei Ye
Praying mantises are a diverse group of predatory insects. Although some Mantodea mitogenomes have been reported, a comprehensive comparative and evolutionary genomic study is lacking for this group. In the present study, four new mitogenomes were sequenced, annotated, and compared to the previously published mitogenomes of other Mantodea species. Most Mantodea mitogenomes share a typical set of mitochondrial genes and a putative control region (CR). Additionally, and most intriguingly, another large non-coding region (LNC) was detected between trnM and ND2 in all six Paramantini mitogenomes examined...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28367100/padi4-epigenetically-suppresses-p21-transcription-and-inhibits-cell-apoptosis-in-fibroblast-like-synoviocytes-from-rheumatoid-arthritis-patients
#4
Lieying Fan, Ming Zong, Ruhan Gong, Dongyi He, Niu Li, Li Shan Sun, Qin Ye, Shanshan Yu
Rheumatoid arthritis (RA) is characterized by synovial lining hyperplasia, which involves abnormal growth of fibroblast-like synoviocytes (FLSs). This study aimed to investigate the function and molecular mechanism of peptidylarginine deiminase type 4 (PADI4) in FLSs isolated from RA patients (RA-FLSs). FLSs were isolated from RA patients and transfected with small interfering RNAs (siRNAs) or PADI4 overexpression plasmid. FLSs were treated by Adriamycin (ADR) to induce apoptosis, and apoptotic cells were detected by flow cytometry...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28367099/identification-of-a-novel-human-long-non-coding-rna-that-regulates-hepatic-lipid-metabolism-by-inhibiting-srebp-1c
#5
Duan Li, Min Cheng, Yuqiang Niu, Xiaojing Chi, Xiuying Liu, Jingjing Fan, Heng Fan, Yongsheng Chang, Wei Yang
Sterol regulatory element binding proteins (SREBPs) are master regulators of hepatic lipid homeostasis. Aberrant expression of SREBPs frequently leads to lipid metabolism dysregulation. Long non-coding RNAs (lncRNAs) have been identified with diverse biological functions, but the effects of lncRNAs on lipid metabolism are rarely reported. Here, we identified a novel human specific lncRNA, lncHR1, as a negative regulator of SREBP-1c expression. Overexpression of lncHR1 inhibited expression of SREBP-1c and fatty acid synthase (FAS) and then repressed oleic acid-induced hepatic cell triglyceride (TG) and lipid droplet (LD) accumulation...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28367098/small-role-with-big-impact-mirnas-as-communicators-in-the-cross-talk-between-cancer-associated-fibroblasts-and-cancer-cells
#6
REVIEW
Zhanhuai Wang, Yinuo Tan, Wei Yu, Shu Zheng, Suzhan Zhang, Lifeng Sun, Kefeng Ding
Cancer microenvironment is composed of numerous components that can support cancer cell proliferation, promote cancer progression and contribute to cancer treatment resistance. The major components of caner microenvironment are fibroblasts, endothelial cells, immune cells as well as cytokines, chemokines, and extracellular matrix (ECM) all of which surround tumor cells as the core and cross talk with each other. Among them, cancer-associated fibroblasts (CAFs) play an important role in promoting cancer progression by secreting various pro-inflammatory factors...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28367097/lyophilized-powder-of-catalpol-and-puerarin-protected-cerebral-vessels-from-ischemia-by-its-anti-apoptosis-on-endothelial-cells
#7
Yang Liu, Qing Tang, Siying Shao, Yi Chen, Weihai Chen, Xiaoyu Xu
Catalpol and puerarin are two monomers of Rehmannia glutinosa and Lobed Kudzuvine Root, which are two herbs commonly used together in ancient prescriptions of traditional Chinese medicine for cerebral ischemia. Our previous study shows that the lyophilized powder of the two monomers improved the outcome of cerebral ischemia excellently in rodents. However, if it protects vessels from ischemia is unknown. The present research studied the protection of lyophilized powder of catalpol and puerarin (CP) on endothelial cells and the relative mechanism in vivo and in vitro...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28367096/effects-of-photodynamic-therapy-using-yellow-led-light-with-concomitant-hypocrellin-b-on-apoptotic-signaling-in-keloid-fibroblasts
#8
Yongqing Hu, Chunmin Zhang, Shengli Li, Ya Jiao, Tonggang Qi, Guo Wei, Gangwen Han
Keloid is a common and refractory disease characterized by abnormal fibroblast proliferation and excessive deposition of extracellular matrix components. Hypocrellin B (HB) is a natural perylene quinone photosensitizer. In this experiment, we studied the effects of photodynamic therapy (PDT) using yellow light from light-emitting diode (LED) combined with HB on keloid fibroblasts (KFB) in vitro. Our results showed that HB-LED PDT treatment induced significant KFB apoptosis and decreased KFB cell viability. HB-LED PDT treatment lead to significant BAX upregulation and BCL-2 downregulation in KFB cells, which led to elevation of intracellular free Ca(2+) and activation of caspase-3...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28367095/high-production-of-2-3-butanediol-by-a-mutant-strain-of-the-newly-isolated-klebsiella-pneumoniae-srp2-with-increased-tolerance-towards-glycerol
#9
Md Shafiqur Rahman, Chunbao Charles Xu, Kesen Ma, Malaya Nanda, Wensheng Qin
Biodiesel, a renewable fuel produced by transesterification of animal fats and vegetable oils, generates about 10% (v/v) of crude glycerol as a core byproduct. The high volume of this non bio-degradable glycerol is becoming of a great environmental and economical concern due to its worldwide ever-growing surplus. Herein we report a high production of 2,3-butanediol (2,3-BD) from pure and biodiesel derived crude glycerol using a mutant K. pneumoniae SRM2 obtained from a newly isolated strain Klebsiella pneumoniae SRP2...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28367094/lncrnas-from-basic-research-to-medical-application
#10
REVIEW
Tao Wu, Yantao Du
This review aimed to summarize the current research contents about long noncoding RNAs (lncRNAs) and some related lncRNAs as molecular biomarkers or therapy strategies in human cancer and cardiovascular diseases. Following the development of various kinds of sequencing technologies, lncRNAs have become one of the most unknown areas that need to be explored. First, the definition and classification of lncRNAs were constantly amended and supplemented because of their complexity and diversity. Second, several methods and strategies have been developed to study the characteristic of lncRNAs, including new species identifications, subcellular localization, gain or loss of function, molecular interaction, and bioinformatics analysis...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28367093/bex2-promotes-tumor-proliferation-in-colorectal-cancer
#11
Yeting Hu, Qian Xiao, Haiyan Chen, Jinjie He, Yinuo Tan, Yue Liu, Zhanhuai Wang, Qi Yang, Xiangfeng Shen, Yu Huang, Ying Yuan, Kefeng Ding
BEX2 has been suggested to promote the tumor growth in breast cancer and glioblastoma, while inhibit the proliferation of glioma cells. Thus, the role of BEX2 in tumor was still in debate. Additionally, the biological functions of BEX2 in colorectal cancer (CRC) have not yet been clarified. Here, we reported that BEX2 was overexpressed in advanced CRC from both the GSE14333 database and fresh CRC tissue specimens, and positively correlated with clinical staging. Knockdown of BEX2 significantly decreased the in vitro proliferation of SW620 colorectal cancer cells, suppressed subcutaneous xenograft growth and enhanced the survival of mice with cecal tumors...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28367092/pkd-knockdown-inhibits-pressure-overload-induced-cardiac-hypertrophy-by-promoting-autophagy-via-akt-mtor-pathway
#12
Di Zhao, Wei Wang, Hao Wang, Honghai Peng, Xiangjuan Liu, Weixing Guo, Guohai Su, Zhuo Zhao
Growing evidence shows that protein kinase D (PKD) plays an important role in the development of pressure overload-induced cardiac hypertrophy. However, the mechanisms involved are not clear. This study tested our hypothesis that PKD might mediate cardiac hypertrophy by negatively regulating autophagy using the technique of PKD knockdown by siRNA. Cardiac hypertrophy was induced in 8-week old male C57BL/6 mice by transverse aortic constriction (TAC). TAC mice were then divided into five groups receiving the treatments of vehicle (DMSO), an autophagy inducer rapamycin (1 mg/kg/day, i...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28367091/disialyl-gd2-ganglioside-suppresses-icam-1-mediated-invasiveness-in-human-breast-cancer-mda-mb231-cells
#13
Kyung-Min Kwon, Tae-Wook Chung, Choong-Hwan Kwak, Hee-Jung Choi, Kyung-Woon Kim, Sun-Hyung Ha, Seung-Hak Cho, Young-Choon Lee, Ki-Tae Ha, Moon-Jo Lee, Cheorl-Ho Kim
The disialoganglioside GD3 has been considered to be involved in tumor progression or suppression in various tumor cells. However, the significance of the biological functions of GD3 in breast cancer cells is still controversial. This prompted us to study the possible relationship(s) between GD3 expression and the metastatic potential of a breast cancer MDA-MB231 cells as an estrogen receptor negative (ER-) type. The human GD3 synthase cDNA was transfected into MDA-MB231 cells, and G-418 bulk selection was used to select cells stably overexpressing the GD3 synthase...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28255277/sirtuin-3-is-required-for-osteogenic-differentiation-through-maintenance-of-pgc-1%C3%A9-sod2-mediated-regulation-of-mitochondrial-function
#14
Yong Ding, Hongmei Yang, Yucai Wang, Jun Chen, Zhenwei Ji, Honghui Sun
Osteogenic differentiation is crucial for the maintenance of bone homeostasis. Sirtuin 3 (SIRT3), a member of sirtuins family, functions as a critical deacetylase that regulates many key proteins. In the current study, we aimed to clarify the role of SIRT3 in osteogenic differentiation and the possible mechanisms, using mouse pre-osteoblastic MC3T3-E1 cells. Expression of SIRT3 was substantially increased in differentiated MC3T3-E1 cells. Knock down of SIRT3 significantly decreased alkaline phosphatase (ALP) staining, and mRNA expression of runt-related transcription factor 2 (Runx2) and collagen type I ɑ 1 (Col1ɑ1), and osteocalcin in differentiated MC3T3-E1 cells...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28255276/melatonin-inhibits-glioblastoma-stem-like-cells-through-suppression-of-ezh2-notch1-signaling-axis
#15
Xiangrong Zheng, Bo Pang, Guangyan Gu, Taihong Gao, Rui Zhang, Qi Pang, Qian Liu
Glioblastoma stem-like cells (GSCs) play essential roles in glioma growth, radio- and chemo-resistance, and recurrence. Elimination of GSCs has therefore become a key strategy and challenge in glioblastoma therapy. Here, we show that melatonin, an indolamine derived from I-tryptophan, significantly inhibited viability and self-renewal ability of GSCs accompanied by a decrease of stem cell markers. We have identified EZH2-NOTCH1 signaling as the key signal pathway that regulated the effects of melatonin in the GSCs...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28255275/exosomes-secreted-from-human-induced-pluripotent-stem-cell-derived-mesenchymal-stem-cells-prevent-osteonecrosis-of-the-femoral-head-by-promoting-angiogenesis
#16
Xiaolin Liu, Qing Li, Xin Niu, Bin Hu, Shengbao Chen, Wenqi Song, Jian Ding, Changqing Zhang, Yang Wang
Background: Local ischemia is the main pathological performance in osteonecrosis of the femoral head (ONFH). There is currently no effective therapy to promote angiogenesis in the femoral head. Recent studies revealed that exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells (iPS-MSC-Exos) have great therapeutic potential in ischemic tissues, but whether they could promote angiogenesis in ONFH has not been reported, and little is known regarding the underlying mechanism. Methods: iPS-MSC-Exos were intravenously injected to a steroid-induced rat osteonecrosis model...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28255274/hyperhomocysteinemia-exacerbates-cisplatin-induced-acute-kidney-injury
#17
Yanjun Long, Xin Zhen, Fengxin Zhu, Zheng Hu, Wenjing Lei, Shuang Li, Yan Zha, Jing Nie
Hyperhomocysteinemia (HHcy) has been linked to several clinical manifestations including chronic kidney disease. However, it is not known whether HHcy has a role in the development of acute kidney injury (AKI). In the present study, we reported that HHcy mice developed more severe renal injury after cisplatin injection and ischemia-reperfusion injury shown as more severe renal tubular damage and higher serum creatinine. In response to cisplatin, HHcy mice showed more prevalent tubular cell apoptosis and decreased tubular cell proliferation...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28255273/increase-in-peripheral-blood-intermediate-monocytes-is-associated-with-the-development-of-recent-onset-type-1-diabetes-mellitus-in-children
#18
Xiaoya Ren, Wenjun Mou, Chang Su, Xi Chen, Hui Zhang, Bingyan Cao, Xiaoqiao Li, Di Wu, Xin Ni, Jingang Gui, Chunxiu Gong
Monocytes play important roles in antigen presentation and cytokine production to achieve a proper immune response, and are therefore largely implicated in the development and progression of autoimmune diseases. The aim of this study was to analyze the change in the intermediate (CD14+CD16+) monocyte subset in children with recent-onset type 1 diabetes mellitus (T1DM) and its possible association with clinical parameters reflecting islet β-cell dysfunction. Compared with age- and sex-matched healthy controls, intermediate monocytes were expanded in children with T1DM, which was positively associated with hemoglobin A1C and negatively associated with serum insulin and C-peptide...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28255272/reverse-the-resistance-to-parp-inhibitors
#19
REVIEW
Yevgeniy Kim, Aleksei Kim, Ainur Sharip, Aigul Sharip, Juhong Jiang, Qing Yang, Yingqiu Xie
One of the DNA repair machineries is activated by Poly (ADP-ribose) Polymerase (PARP) enzyme. Particularly, this enzyme is involved in repair of damages to single-strand DNA, thus decreasing the chances of generating double-strand breaks in the genome. Therefore, the concept to block PARP enzymes by PARP inhibitor (PARPi) was appreciated in cancer treatment. PARPi has been designed and tested for many years and became a potential supplement for the conventional chemotherapy. However, increasing evidence indicates the appearance of the resistance to this treatment...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28255271/ssc-mir-7134-3p-regulates-fat-accumulation-in-castrated-male-pigs-by-targeting-mark4-gene
#20
Kejun Wang, Wenting Li, Ying Bai, Wanjie Yang, Yao Ling, Meiying Fang
Castration of male pigs is a common practice used to reduce boar taint in commercial pork production, but it also significantly results in fat accumulation in carcass. Our previous study revealed a miRNA gene, ssc-miR-7134-3p that was implicated in adipogenesis. However, the relationship between ssc-miR-7134-3p and fat deposition due to castration is unknown. In the present study, we observed that ssc-miR-7134-3p targets the coding sequence (CDS) region of MARK4 based on bioinformatics analysis and dual-luciferase assays...
2017: International Journal of Biological Sciences
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