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Immunity & Ageing: I & A

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https://www.readbyqxmd.com/read/28413428/transcriptomic-evidence-of-a-para-inflammatory-state-in-the-middle-aged-lumbar-spinal-cord
#1
William Galbavy, Yong Lu, Martin Kaczocha, Michelino Puopolo, Lixin Liu, Mario J Rebecchi
BACKGROUND: We have previously reported elevated expression of multiple pro-inflammatory markers in the lumbar spinal cord (LSC) of middle-aged male rats compared to young adults suggesting a para-inflammatory state develops in the LSC by middle age, a time that in humans is associated with the greatest pain prevalence and persistence. The goal of the current study was to examine the transcriptome-wide gene expression differences between young and middle aged LSC. METHODS: Young (3 month) and middle-aged (17 month) naïve Fisher 344 rats (n = 5 per group) were euthanized, perfused with heparinized saline, and the LSC were removed...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28413427/immunogenicity-and-safety-of-a-respiratory-syncytial-virus-fusion-protein-rsv-f-nanoparticle-vaccine-in-older-adults
#2
Louis Fries, Vivek Shinde, Jeffrey J Stoddard, D Nigel Thomas, Eloi Kpamegan, Hanxin Lu, Gale Smith, Somia P Hickman, Pedro Piedra, Gregory M Glenn
BACKGROUND: A preventative strategy for Respiratory Syncytial Virus (RSV) infection constitutes an under-recognized unmet medical need among older adults. Four formulations of a novel recombinant RSV F nanoparticle vaccine (60 or 90 μg RSV F protein, with or without aluminum phosphate adjuvant) administered concurrently with a licensed inactivated trivalent influenza vaccine (TIV) in older adult subjects were evaluated for safety and immunogenicity in this randomized, observer-blinded study...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28331525/the-anti-ageing-molecule-sirt1-mediates-beneficial-effects-of-cardiac-rehabilitation
#3
Giusy Russomanno, Graziamaria Corbi, Valentina Manzo, Nicola Ferrara, Giuseppe Rengo, Annibale A Puca, Salvatore Latte, Albino Carrizzo, Maria Consiglia Calabrese, Ramaroson Andriantsitohaina, Walter Filippelli, Carmine Vecchione, Amelia Filippelli, Valeria Conti
BACKGROUND: An exercise-based Cardiac Rehabilitation Programme (CRP) is established as adjuvant therapy in heart failure (HF), nevertheless it is underutilized, especially in the elderly. While the functional and hemodynamic effects of CRP are well known, its underlying molecular mechanisms have not been fully clarified. The present study aims to evaluate the effects of a well-structured 4-week CRP in patients with stable HF from a molecular point of view. RESULTS: A prospective longitudinal observational study was conducted on patients consecutively admitted to cardiac rehabilitation...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28293269/cxcl-16-il-17-and-bone-morphogenetic-protein-2-bmp-2-are-associated-with-overweight-and-obesity-conditions-in-middle-aged-and-elderly-women
#4
Silvana Mara Turbino Luz Ribeiro, Laís Roquete Lopes, Guilherme de Paula Costa, Vivian Paulino Figueiredo, Deena Shrestha, Aline Priscila Batista, Roney Luiz de Carvalho Nicolato, Fernando Luiz Pereira de Oliveira, Juliana Assis Silva Gomes, Andre Talvani
BACKGROUND: The current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears to contribute to the development of some obesity-related comorbidities. Interventions that directly or indirectly target individuals at high risk of developing obesity have been largely proposed because of the increasing number of overweight/obese cases worldwide. The aim of the present study was to assess CXCL16, IL-17, and BMP-2 plasma factors in middle-aged and elderly women and relate them to an overweight or obese status...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28250797/changes-in-peripheral-immune-cell-numbers-and-functions-in-octogenarian-walkers-an-acute-exercise-study
#5
Kornelis S M van der Geest, Qi Wang, Thijs M H Eijsvogels, Hans J P Koenen, Irma Joosten, Elisabeth Brouwer, Maria T E Hopman, Joannes F M Jacobs, Annemieke M H Boots
BACKGROUND: Age-related changes of the immune system, termed immunosenescence, may underlie the increased risk of infections and morbidity in the elderly. Little is known about the effects of acute exercise on peripheral immune parameters in octogenarians. Therefore, we investigated acute exercise-induced changes in phenotype and function of the immune system in octogenarians participating in the 2013 edition of the Nijmegen Four Days Marches. Blood sampling was performed at baseline and immediately after 4 days of the walking exercise (30 km/day)...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28239399/erratum-to-frailty-has-a-stronger-association-with-inflammation-than-age-in-older-veterans
#6
P Van Epps, D Oswald, P A Higgins, T R Hornick, H Aung, R E Banks, B M Wilson, C Burant, S Gravenstein, D H Canaday
[This corrects the article DOI: 10.1186/s12979-016-0082-z.].
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28138335/lifewide-profile-of-cytokine-production-by-innate-and-adaptive-immune-cells-from-brazilian-individuals
#7
Gabriela Silveira-Nunes, Elaine Speziali, Andréa Teixeira-Carvalho, Danielle M Vitelli-Avelar, Renato Sathler-Avelar, Taciana Figueiredo-Soares, Maria Luiza Silva, Vanessa Peruhype-Magalhães, Daniel Gonçalves Chaves, Gustavo Eustáquio Brito-Melo, Glenda Meira Cardoso, Eric Bassetti Soares, Silvana Maria Elói-Santos, Rosângela Teixeira, Dulciene Magalhães Queiroz, Rodrigo Corrêa-Oliveira, Ana Maria Caetano Faria, Olindo Assis Martins-Filho
BACKGROUND: Immunosenescence is associated with several changes in adaptive and innate immune cells. Altered cytokine production is among the most prominent of these changes. The impact of age-related alterations on cytokine global profiles produced by distinct populations of leukocytes from healthy Brazilian individuals was studied. We analysed frequencies of cytokine-producing lymphocytes and innate immune cells from individuals at several ages spanning a lifetime period (0-85 years)...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28127381/expression-of-cellular-protective-proteins-sirt1-hsp70-and-sod2-correlates-with-age-and-is-significantly-higher-in-nk-cells-of-the-oldest-seniors
#8
Lucyna Kaszubowska, Jerzy Foerster, Jan Jacek Kaczor, Daria Schetz, Tomasz Jerzy Ślebioda, Zbigniew Kmieć
BACKGROUND: NK cells are key effector lymphocytes of innate immunity provided with constitutive cytolytic activity, however, their role in human ageing is not entirely understood. The study aimed to analyze the expression of proteins involved in cellular stress response sirtuin 1 (SIRT1), heat shock protein 70 (HSP70) and manganese superoxide dismutase (SOD2) in non-stimulated NK cells of the oldest seniors (n = 25; aged over 85; mean age 88 years) and compare with NK cells of the old (n = 30; aged under 85; mean age 76 years) and the young (n = 32; mean age 21 years) to find potential relationships between the level of expression of these proteins in NK cells and longevity...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28070203/a-pilot-observational-study-on-magnesium-and-calcium-imbalance-in-elderly-patients-with-acute-aortic-dissection
#9
E Vianello, E Dozio, A Barassi, G Sammarco, L Tacchini, M M Marrocco-Trischitta, S Trimarchi, M M Corsi Romanelli
BACKGROUND: Magnesium (Mg) and calcium (Ca) are the principal essential elements involved in endothelial cell homeostasis. Extracellular changes in the levels of either alter endothelial contraction and dilatation. Consequently Mg and Ca imbalance is associated with a high risk of endothelial dysfunction, the main process observed during acute aortic dissection (AAD); in this clinical condition, which mainly affects elderly men, smooth muscle cell alterations lead to intimal tears, creating a false new lumen in the media of the aorta...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27777599/frailty-has-a-stronger-association-with-inflammation-than-age-in-older-veterans
#10
P Van Epps, D Oswald, P A Higgins, T R Hornick, H Aung, R E Banks, B M Wilson, C Burant, S Graventstein, D H Canaday
BACKGROUND: Upregulation of pro-inflammatory cytokines has not only been associated with increased morbidity and mortality in older adults but also has been linked to frailty. In the current study we aimed to compare the relative relationship of age and frailty on inflammation and thrombosis in older veterans. RESULTS: We analyzed 117 subjects (age range 62-95 years; median 81) divided into 3 cohorts: non-frail, pre-frail and frail based on the Fried phenotype of frailty...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27602049/booster-vaccination-against-tetanus-and-diphtheria-insufficient-protection-against-diphtheria-in-young-and-elderly-adults
#11
Marco Grasse, Andreas Meryk, Michael Schirmer, Beatrix Grubeck-Loebenstein, Birgit Weinberger
We have recently demonstrated that single shot vaccinations against tetanus and diphtheria do not lead to long-lasting immunity against diphtheria in elderly persons despite administration at 5 year intervals. In the present study we have immunized a group of young adults against tetanus and diphtheria to compare the pre- and 28 days post-vaccination immune responses in the young group with results of the same vaccination performed in an elderly group of a previous study. We also studied protection in both groups 5 years after vaccination...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27559355/the-inflammatory-protein-pentraxin-3-in-cardiovascular-disease
#12
REVIEW
Francesco Fornai, Albino Carrizzo, Maurizio Forte, Mariateresa Ambrosio, Antonio Damato, Michela Ferrucci, Francesca Biagioni, Carla Busceti, Annibale A Puca, Carmine Vecchione
The acute phase protein Pentraxin 3 (PTX3) plays a non-redundant role as a soluble pattern recognition receptor for selected pathogens and it represents a rapid biomarker for primary local activation of innate immunity and inflammation. Recent evidence indicates that PTX3 exerts an important role in modulating the cardiovascular system in humans and experimental models. In particular, there are conflicting points concerning the effects of PTX3 in cardiovascular diseases (CVD) since several observations indicate a cardiovascular protective effect of PTX3 while others speculate that the increased plasma levels of PTX3 in subjects with CVD correlate with disease severity and with poor prognosis in elderly patients...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27547234/changes-in-blood-lymphocyte-numbers-with-age-in-vivo-and-their-association-with-the-levels-of-cytokines-cytokine-receptors
#13
Yun Lin, Jiewan Kim, E Jeffrey Metter, Huy Nguyen, Thai Truong, Ana Lustig, Luigi Ferrucci, Nan-Ping Weng
BACKGROUND: Alterations in the number and composition of lymphocytes and their subsets in blood are considered a hallmark of immune system aging. However, it is unknown whether the rates of change of lymphocytes are stable or change with age, or whether the inter-individual variations of lymphocyte composition are stable over time or undergo different rates of change at different ages. Here, we report a longitudinal analysis of T- and B-cells and their subsets, and NK cells in the blood of 165 subjects aged from 24 to 90 years, with each subject assessed at baseline and an average of 5...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27398086/redox-modulation-of-cellular-stress-response-and-lipoxin-a4-expression-by-hericium-erinaceus-in-rat-brain-relevance-to-alzheimer-s-disease-pathogenesis
#14
A Trovato, R Siracusa, R Di Paola, M Scuto, M L Ontario, Ornella Bua, Paola Di Mauro, M A Toscano, C C T Petralia, L Maiolino, A Serra, S Cuzzocrea, Vittorio Calabrese
BACKGROUND: There has been a recent upsurge of interest in complementary medicine, especially dietary supplements and foods functional in delaying the onset of age-associated neurodegenerative diseases. Mushrooms have long been used in traditional medicine for thousands of years, being now increasingly recognized as antitumor, antioxidant, antiviral, antibacterial and hepatoprotective agent also capable to stimulate host immune responses. RESULTS: Here we provide evidence of neuroprotective action of Hericium Herinaceus when administered orally to rat...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27375767/elastic-band-resistance-training-influences-transforming-growth-factor-%C3%A3-receptor-i-mrna-expression-in-peripheral-mononuclear-cells-of-institutionalised-older-adults-the-vienna-active-ageing-study-vaas
#15
Barbara Schober-Halper, Marlene Hofmann, Stefan Oesen, Bernhard Franzke, Thomas Wolf, Eva-Maria Strasser, Norbert Bachl, Michael Quittan, Karl-Heinz Wagner, Barbara Wessner
BACKGROUND: Ageing, inactivity and obesity are associated with chronic low-grade inflammation contributing to a variety of lifestyle-related diseases. Transforming growth factor-β (TGF-β) is a multimodal protein with various cellular functions ranging from tissue remodelling to the regulation of inflammation and immune functions. While it is generally accepted that aerobic exercise exerts beneficial effects on several aspects of immune functions, even in older adults, the effect of resistance training remains unclear...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27274758/interleukin-6-and-c-reactive-protein-successful-aging-and-mortality-the-polsenior-study
#16
Monika Puzianowska-Kuźnicka, Magdalena Owczarz, Katarzyna Wieczorowska-Tobis, Pawel Nadrowski, Jerzy Chudek, Przemyslaw Slusarczyk, Anna Skalska, Marta Jonas, Edward Franek, Malgorzata Mossakowska
BACKGROUND: In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for the development of aging-related diseases and frailty. Using data from several thousand Eastern Europeans aged 65 years and older, we investigated whether the serum levels of two proinflammatory factors, interleukin-6 (IL-6) and C-reactive protein (CRP), were associated with physical and cognitive performance, and could predict mortality in successfully aging elderly. RESULTS: IL-6 and CRP levels systematically increased in an age-dependent manner in the entire study group (IL-6: n = 3496 individuals, p < 0...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27247610/the-prognostic-value-of-biomarkers-in-stroke
#17
Francesco Iemolo, Enzo Sanzaro, Giovanni Duro, Antonello Giordano, Maurizio Paciaroni
BACKGROUND: Ischemic injury triggers inflammatory cascades and changes in the protein synthesis, neurotransmitters and neuro-hormones in the brain parenchyma that may further amplify the tissue damage. The "Triage® Stroke Panel", a biochemical multimarker assay, detects Brain Natriuretic Peptide (BNP), D-Dimers (DD), Matrix-Metalloproteinase-9 (MMP-9), and S100β protein generating a Multimarker index of these values (MMX). The aims of this prospective study in consecutive patients with ischemic or hemorrhagic stroke were to assess: 1) the rate of an increase of biomarkers (BNP, D-dimer, MMP-9 and S-100β) tested with the Triage Stroke Panel; 2) the correlation between the increase of these biomarkers and functional outcome at 4 months; 3) the risk factors for the increase of biomarkers...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27239218/role-of-androgens-in-dhea-induced-rack1-expression-and-cytokine-modulation-in-monocytes
#18
Emanuela Corsini, Valentina Galbiati, Angela Papale, Elena Kummer, Antonella Pinto, Melania M Serafini, Antonio Guaita, Roberto Spezzano, Donatella Caruso, Marina Marinovich, Marco Racchi
BACKGROUND: Over the past fifteen years, we have demonstrated that cortisol and dehydroepiandrosterone (DHEA) have opposite effects on the regulation of protein kinase C (PKC) activity in the context of the immune system. The anti-glucocorticoid effect of DHEA is also related to the regulation of splicing of the glucocorticoid receptor (GR), promoting the expression of GRβ isoform, which acts as a negative dominant form on GRα activity. Moreover, it is very well known that DHEA can be metabolized to androgens like testosterone, dihydrotestosterone (DHT), and its metabolites 3α-diol and 3β-diol, which exert their function through the binding of the androgen receptor (AR)...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27213002/nutrigerontology-a-key-for-achieving-successful-ageing-and-longevity
#19
Anna Aiello, Giulia Accardi, Giuseppina Candore, Giuseppe Carruba, Sergio Davinelli, Giuseppe Passarino, Giovanni Scapagnini, Sonya Vasto, Calogero Caruso
During the last two centuries the average lifespan has increased at a rate of approximately 3 months/year in both sexes, hence oldest old people are becoming the population with the fastest growth in Western World. Although the average life expectancy is increasing dramatically, the healthy lifespan is not going at the same pace. This underscores the importance of studies on the prevention of age-related diseases, in order to satisfactorily decrease the medical, economic and social problems associated to advancing age, related to an increased number of individuals not autonomous and affected by invalidating pathologies...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27152115/effects-of-thermal-water-inhalation-in-chronic-upper-respiratory-tract-infections-in-elderly-and-young-patients
#20
Thea Magrone, Mauro Galantino, Nunzio Di Bitonto, Luisella Borraccino, Gerardo Chiaromonte, Emilio Jirillo
BACKGROUND: Chronic upper respiratory tract infections (cURTI) are very frequent illnesses which occur at any age of life. In elderly, cURTI are complicated by immunosenescence, with involvement of lung immune responsiveness. RESULTS: In the present study, 51 elderly (age range: 66-86) and 51 young (age range 24-58) cURTI patients underwent a single cycle (two weeks) of inhalatory therapy with salt-bromide-iodine thermal water in the thermal station "Margherita di Savoia" (Margherita di Savoia, BAT, Italy)...
2016: Immunity & Ageing: I & A
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