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Immunity & Ageing: I & A

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https://www.readbyqxmd.com/read/30093911/virtual-memory-cells-make-a-major-contribution-to-the-response-of-aged-influenza-na%C3%A3-ve-mice-to-influenza-virus-infection
#1
Kathleen G Lanzer, Tres Cookenham, William W Reiley, Marcia A Blackman
Background: A diverse repertoire of naïve T cells is thought to be essential for a robust response to new infections. However, a key aspect of aging of the T cell compartment is a decline in numbers and diversity of peripheral naïve T cells. We have hypothesized that the age-related decline in naïve T cells forces the immune system to respond to new infections using cross-reactive memory T cells generated to previous infections that dominate the aged peripheral T cell repertoire. Results: Here we confirm that the CD8 T cell response of aged, influenza-naïve mice to primary infection with influenza virus is dominated by T cells that derive from the memory T cell pool...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30026783/esrd-associated-immune-phenotype-depends-on-dialysis-modality-and-iron-status-clinical-implications
#2
Didier Ducloux, Mathieu Legendre, Jamal Bamoulid, Jean-Michel Rebibou, Philippe Saas, Cécile Courivaud, Thomas Crepin
Background: End-stage renal disease (ESRD) causes premature ageing of the immune system. However, it is not known whether hemodialysis (HD) and peritoneal dialysis (PD) similarly affect the T cell system. Methods: The aim of our study was to analyse whether dialysis modality may mitigate ESRD-induced immune senescence. We explored a large population of patients (675 ESRD patients) and both confirmed and refined the results in a second cohort (84 patients). Results: HD patients exhibited higher inflammatory monocytes counts (44/mm3 (1-520) vs 36/mm3 (1-161); p  = 0...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29988679/anti-cytomegalovirus-igg-antibody-titer-is-positively-associated-with-advanced-t-cell-differentiation-and-coronary-artery-disease-in-end-stage-renal-disease
#3
Feng-Jung Yang, Kai-Hsiang Shu, Hung-Yuan Chen, I-Yu Chen, Fang-Yun Lay, Yi-Fang Chuang, Chien-Sheng Wu, Wan-Chuan Tsai, Yu-Sen Peng, Shih-Ping Hsu, Chih-Kang Chiang, George Wang, Yen-Ling Chiu
Background: Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individuals with normal renal function. Patients with end-stage renal disease (ESRD) exhibit impaired immune function and thus may face higher risk of HCMV-related adverse outcomes. Whether the level of anti-HCMV immune response may be associated with the prognosis of hemodialysis patients is unknown...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29983721/a-study-on-the-relationship-between-waist-phenotype-hypertriglyceridemia-coronary-artery-lesions-and-serum-free-fatty-acids-in-adult-and-elderly-patients-with-coronary-diseases
#4
Rui-Feng Yang, Hanlei Zhang, Zhongchun Wang, Xiao-Yong Liu, Zhi Lin
Background: Abdominal obesity is an independent risk factor for coronary heart disease (CHD) and high serum triglyceride (TG) and free fatty acid levels may precipitate or aggravate CHD. Methods: We enrolled patients with coronary heart disease in our hospital from October 2008 to July 2009. Patients with high TG and increased WC, i.e. waist phenotype WP were included in group A. In group B, were included patients with high TG but not WP. Group C consisted of patients with WP but not high TG...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29755573/thymus-and-activation-regulated-chemokine-tarc-ccl17-and-ige-are-associated-with-elderly-asthmatics
#5
Kyung Mi Jo, Hyo Kyung Lim, Jae Woong Sull, Eugene Choi, Ji-Sook Lee, Mee Ae Cheong, Min Hwa Hong, Yoori Kim, In Sik Kim
Background: The pathogenesis of asthma, which is an allergic lung disease, is associated with a variety of allergens such as house dust mite, pollen, and mould, IgE containing serum IgE and allergen-specific-IgE, and inflammatory cytokines including thymus and activation-regulated chemokine (TARC)/CCL17. Because aging is an essential factor in the pathogenesis of asthma, we examined biomarkers related to asthmatic subjects depending on age. Results: Physiological indices such as FEV1(forced expiratory capacity in 1 s), FEV1 (% predicted), and FEV1/FVC(forced vital capacity) (%) in asthmatic subjects were lower than those in normal subjects...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29541147/nk-cells-of-the-oldest-seniors-represent-constant-and-resistant-to-stimulation-high-expression-of-cellular-protective-proteins-sirt1-and-hsp70
#6
Lucyna Kaszubowska, Jerzy Foerster, Jan Jacek Kaczor, Daria Schetz, Tomasz Jerzy Ślebioda, Zbigniew Kmieć
Background: Natural killer cells (NK cells) are cytotoxic lymphocytes of innate immunity that reveal some immunoregulatory properties, however, their role in the process of ageing is not completely understood. The study aimed to analyze the expression of proteins involved in cellular stress response: sirtuin 1 (SIRT1), heat shock protein 70 (HSP70) and manganese superoxide dismutase (SOD2) in human NK cells with reference to the process of ageing. Non-stimulated and stimulated with IL-2, LPS or PMA with ionomycin cells originated from peripheral blood samples of: seniors aged over 85 ('the oldest'; n  = 25; 88...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29507595/immune-inflammatory-responses-in-the-elderly-an-update
#7
EDITORIAL
Giulia Accardi, Calogero Caruso
No abstract text is available yet for this article.
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29497453/gene-and-protein-expression-of-cxcr4-in-adult-and-elderly-patients-with-chronic-rhinitis-pharyngitis-or-sinusitis-undergoing-thermal-water-nasal-inhalations
#8
Monica Neri, Luigi Sansone, Luisa Pietrasanta, Aliaksei Kisialiou, Eloisa Cabano, Marina Martini, Matteo A Russo, Donatella Ugolini, Marco Tafani, Stefano Bonassi
Background: Chronic rhinitis, pharyngitis and sinusitis are common health problems with a significant impact on public health, and are suspected to be influenced by ageing factors. Nasal inhalation with thermal water may be used to reduce symptoms, inflammation and drug intake. A pre-post clinical study was conducted in 183 consecutive adult and elderly patients with chronic rhinitis, pharyngitis or sinusitis, to evaluate whether thermal water nasal inhalations could improve their symptoms, clinical signs and rhinomanometry measurements, and influence inflammatory biomarkers levels in nasal epithelial cells...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29456585/neuroinflammation-and-neurohormesis-in-the-pathogenesis-of-alzheimer-s-disease-and-alzheimer-linked-pathologies-modulation-by-nutritional-mushrooms
#9
REVIEW
Angela Trovato Salinaro, Manuela Pennisi, Rosanna Di Paola, Maria Scuto, Rosalia Crupi, Maria Teresa Cambria, Maria Laura Ontario, Mario Tomasello, Maurizio Uva, Luigi Maiolino, Edward J Calabrese, Salvatore Cuzzocrea, Vittorio Calabrese
Human life develops and expands not only in time and space, but also in the retrograde permanent recollection and interweaving of memories. Therefore, individual human identity depends fully on a proper access to the autobiographical memory. Such access is hindered or lost under pathological conditions such as Alzheimer's disease, including recently associated oxidant pathologies, such as ocular neural degeneration occurring in glaucoma or neurosensorial degeneration occurring in Menière's disease. Oxidative stress and altered antioxidant systems have been suggested to play a role in the aetiology of major neurodegenerative disorders, and altered expression of genes sensing oxidative stress, as well as decreased cellular stress response mechanisms could synergistically contribute to the course of these oxidant disorders...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29445414/effects-of-a-new-nutraceutical-combination-on-cognitive-function-in-hypertensive-patients
#10
Giuseppe Giugliano, Alessia Salemme, Sara De Longis, Marialuisa Perrotta, Valentina D'Angelosante, Alessandro Landolfi, Raffaele Izzo, Valentina Trimarco
Background: Chronic increased arterial blood pressure has been associated with executive dysfunction, slowing of attention and mental processing speed, and later with memory deficits. Due to the absence of a concrete therapeutic approach to this pathophysiological process, in the last decades there has been an increasing interest in the use of nutraceuticals, especially those with antioxidant properties, which own strong neuroprotective potential, that may help to improve cognitive function and to delay the onset of dementia...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29422938/-porphyromonas-gingivalis-a-periodontitis-causing-bacterium-induces-memory-impairment-and-age-dependent-neuroinflammation-in-mice
#11
Ye Ding, Jingyi Ren, Hongqiang Yu, Weixian Yu, Yanmin Zhou
Background: A possible relationship between periodontitis and Alzheimer's disease (AD) has been reported. However, there is limited information on the association between the Porphyromonas gingivalis ( P. gingivalis ) periodontal infection and the pathological features of AD. The hypothesis that P. gingivalis periodontal infection may cause cognitive impairment via age-dependent neuroinflammation was tested. Results: Thirty 4-week-old (young) female C57BL/6 J mice were randomly divided into two groups, the control group and the experimental group...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29416551/interventions-to-restore-appropriate-immune-function-in-the-elderly
#12
REVIEW
Richard Aspinall, Pierre Olivier Lang
Advanced age is one indicator of likely immune dysfunction. As worldwide, the global population contains progressively more and more older individuals there is likelihood of an increased prevalence and incidence of infectious diseases due to common and emergent pathogens. The resultant increase in mortality and morbidity would be matched by the risk of functional decline and disability. Maintaining immune function at a plateau throughout life may therefore be associated with considerable cost savings. The aim of improving immune function in older individuals may be achieved through considering a therapeutic approach to rejuvenate, stimulate or support the indigenous immune system to perform in a more optimal manner...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29387136/the-association-of-high-sensitivity-c-reactive-protein-and-incident-alzheimer-disease-in-patients-60-years-and-older-the-hunt-study-norway
#13
Jessica Mira Gabin, Ingvild Saltvedt, Kristian Tambs, Jostein Holmen
Background: With ageing, long-standing inflammation can be destructive, contributing to development of several disorders, among these Alzheimer's disease (AD). C-reactive protein (CRP) is a relatively stable peripheral inflammatory marker, but in previous studies the association between highly sensitive CRP (hsCRP) and AD have shown inconsistent results. This study examines the association between AD and hsCRP in blood samples taken up to 15 years prior to the diagnoses of 52 persons with AD amongst a total of 2150 persons ≥60 years of age...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29387135/vaccines-for-the-elderly-current-use-and-future-challenges
#14
REVIEW
Birgit Weinberger
Age-related changes of the immune system contribute to increased incidence and severity of infections in the elderly. Vaccination is the most effective measure to prevent infections and vaccination recommendations in most countries include specific guidelines for the elderly. Vaccination against influenza and Streptococcus pneumoniae is usually recommended for persons with underlying diseases and for the elderly with heterogeneous age limits between ≥ 50 years and ≥ 65 years. Some countries also recommend vaccination against herpes zoster...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29387134/molecular-changes-associated-with-increased-tnf-%C3%AE-induced-apoptotis-in-na%C3%A3-ve-t-n-and-central-memory-t-cm-cd8-t-cells-in-aged-humans
#15
Sudhir Gupta, Houfen Su, Sudhanshu Agrawal, Sastry Gollapudi
Background: Progressive T cell decline in aged humans is associated with a deficiency of naïve (TN ) and central memory (TCM ) T cells. We have previously reported increased Tumor necrosis factor-α (TNF-α)-induced apoptosis in TN and TCM T cells in aged humans; however, the molecular basis of increased apoptosis remains to be defined. Since expression of TNF receptors (TNFRs) was reported to be comparable in young and aged, we investigated signaling events downstream of TNFRs to understand the molecular basis of increased TNF-α-induced apoptosis in aged TN and TCM CD8+ cells...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29387133/ageing-from-inflammation-to-cancer
#16
REVIEW
Giulia C Leonardi, Giulia Accardi, Roberto Monastero, Ferdinando Nicoletti, Massimo Libra
Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hallmark of cancer and is widely recognized to influence all cancer stages from cell transformation to metastasis. Therefore, inflammaging may represent the biological phenomena able to couple ageing process with cancer development. Here we review the molecular and cellular pathway involved in age-related chronic inflammation along with its potential triggers and their connection with cancer development...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29296117/immunological-and-non-immunological-mechanisms-of-allergic-diseases-in-the-elderly-biological-and-clinical-characteristics
#17
REVIEW
Gabriele Di Lorenzo, Danilo Di Bona, Federica Belluzzo, Luigi Macchia
A better hygiene, a Westernized diet, air pollution, climate changes, and other factors that influence host microbiota, a key player in the induction and maintenance of immunoregulatory circuits and tolerance, are thought to be responsible for the increase of allergic diseases observed in the last years. The increase of allergic diseases in elderly is related to the presence of other factors as several comorbidities that should interfere with the development and the type of allergic reactions. A central role is played by immunosenescence responsible for modifying response to microbiota and triggering inflamm-ageing...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29176992/immunosenescence-in-persons-with-spinal-cord-injury-in-relation-to-urinary-tract-infections-a-cross-sectional-study
#18
David Pavlicek, Jörg Krebs, Simona Capossela, Alessandro Bertolo, Britta Engelhardt, Jürgen Pannek, Jivko Stoyanov
Background: Individuals with a spinal cord injury (SCI), despite specialized rehabilitation and good health care, have a reduced life expectancy. Infectious diseases, such as pneumonias, infected pressure sores and urinary tract infections (UTI) have been identified as the leading causes of mortality. We hypothesise that a premature onset of immune frailty occurs in SCI, possibly caused also by recurrent urinary tract infections.A cross sectional study was performed comparing blood and urine samples between able bodied controls ( n  = 84) and persons with spinal cord injury ( n  = 85)...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29163665/chlorinative-stress-in-age-related-diseases-a-literature-review
#19
REVIEW
Marco Casciaro, Eleonora Di Salvo, Elisabetta Pace, Elvira Ventura-Spagnolo, Michele Navarra, Sebastiano Gangemi
Aging is an agglomerate of biological long-lasting processes that result being inevitable. Main actors in this scenario are both long-term inflammation and oxidative stress. It has been proved that oxidative stress induce alteration in proteins and this fact itself is critically important in the pathophysiological mechanisms leading to diseases typical of aging. Among reactive species, chlorine ones such as hypochlorous acid (HOCl) are cytotoxic oxidants produced by activated neutrophils during chronic inflammation processes...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28874912/prescription-database-analyses-indicates-that-the-asthma-medicine-montelukast-might-protect-against-dementia-a-hypothesis-to-be-verified
#20
Bjørn Grinde, Bo Engdahl
BACKGROUND: It has recently been shown that the leukotriene receptor antagonist montelukast rejuvenates aged brains in rats. The question is whether this commonly used, systemic, anti-asthmatic medicine has a similar effect in humans? RESULTS: We approached this issue by doing statistical analyses based on the Norwegian Prescription Database. The Database lists all prescription-based medications in Norway, but not drugs given to people who are in hospitals or nursing homes...
2017: Immunity & Ageing: I & A
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