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Immunity & Ageing: I & A

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https://www.readbyqxmd.com/read/27777599/frailty-has-a-stronger-association-with-inflammation-than-age-in-older-veterans
#1
P Van Epps, D Oswald, P A Higgins, T R Hornick, H Aung, R E Banks, B M Wilson, C Burant, S Graventstein, D H Canaday
BACKGROUND: Upregulation of pro-inflammatory cytokines has not only been associated with increased morbidity and mortality in older adults but also has been linked to frailty. In the current study we aimed to compare the relative relationship of age and frailty on inflammation and thrombosis in older veterans. RESULTS: We analyzed 117 subjects (age range 62-95 years; median 81) divided into 3 cohorts: non-frail, pre-frail and frail based on the Fried phenotype of frailty...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27602049/booster-vaccination-against-tetanus-and-diphtheria-insufficient-protection-against-diphtheria-in-young-and-elderly-adults
#2
Marco Grasse, Andreas Meryk, Michael Schirmer, Beatrix Grubeck-Loebenstein, Birgit Weinberger
We have recently demonstrated that single shot vaccinations against tetanus and diphtheria do not lead to long-lasting immunity against diphtheria in elderly persons despite administration at 5 year intervals. In the present study we have immunized a group of young adults against tetanus and diphtheria to compare the pre- and 28 days post-vaccination immune responses in the young group with results of the same vaccination performed in an elderly group of a previous study. We also studied protection in both groups 5 years after vaccination...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27559355/the-inflammatory-protein-pentraxin-3-in-cardiovascular-disease
#3
REVIEW
Francesco Fornai, Albino Carrizzo, Maurizio Forte, Mariateresa Ambrosio, Antonio Damato, Michela Ferrucci, Francesca Biagioni, Carla Busceti, Annibale A Puca, Carmine Vecchione
The acute phase protein Pentraxin 3 (PTX3) plays a non-redundant role as a soluble pattern recognition receptor for selected pathogens and it represents a rapid biomarker for primary local activation of innate immunity and inflammation. Recent evidence indicates that PTX3 exerts an important role in modulating the cardiovascular system in humans and experimental models. In particular, there are conflicting points concerning the effects of PTX3 in cardiovascular diseases (CVD) since several observations indicate a cardiovascular protective effect of PTX3 while others speculate that the increased plasma levels of PTX3 in subjects with CVD correlate with disease severity and with poor prognosis in elderly patients...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27547234/changes-in-blood-lymphocyte-numbers-with-age-in-vivo-and-their-association-with-the-levels-of-cytokines-cytokine-receptors
#4
Yun Lin, Jiewan Kim, E Jeffrey Metter, Huy Nguyen, Thai Truong, Ana Lustig, Luigi Ferrucci, Nan-Ping Weng
BACKGROUND: Alterations in the number and composition of lymphocytes and their subsets in blood are considered a hallmark of immune system aging. However, it is unknown whether the rates of change of lymphocytes are stable or change with age, or whether the inter-individual variations of lymphocyte composition are stable over time or undergo different rates of change at different ages. Here, we report a longitudinal analysis of T- and B-cells and their subsets, and NK cells in the blood of 165 subjects aged from 24 to 90 years, with each subject assessed at baseline and an average of 5...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27398086/redox-modulation-of-cellular-stress-response-and-lipoxin-a4-expression-by-hericium-erinaceus-in-rat-brain-relevance-to-alzheimer-s-disease-pathogenesis
#5
A Trovato, R Siracusa, R Di Paola, M Scuto, M L Ontario, Ornella Bua, Paola Di Mauro, M A Toscano, C C T Petralia, L Maiolino, A Serra, S Cuzzocrea, Vittorio Calabrese
BACKGROUND: There has been a recent upsurge of interest in complementary medicine, especially dietary supplements and foods functional in delaying the onset of age-associated neurodegenerative diseases. Mushrooms have long been used in traditional medicine for thousands of years, being now increasingly recognized as antitumor, antioxidant, antiviral, antibacterial and hepatoprotective agent also capable to stimulate host immune responses. RESULTS: Here we provide evidence of neuroprotective action of Hericium Herinaceus when administered orally to rat...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27375767/elastic-band-resistance-training-influences-transforming-growth-factor-%C3%A3-receptor-i-mrna-expression-in-peripheral-mononuclear-cells-of-institutionalised-older-adults-the-vienna-active-ageing-study-vaas
#6
Barbara Schober-Halper, Marlene Hofmann, Stefan Oesen, Bernhard Franzke, Thomas Wolf, Eva-Maria Strasser, Norbert Bachl, Michael Quittan, Karl-Heinz Wagner, Barbara Wessner
BACKGROUND: Ageing, inactivity and obesity are associated with chronic low-grade inflammation contributing to a variety of lifestyle-related diseases. Transforming growth factor-β (TGF-β) is a multimodal protein with various cellular functions ranging from tissue remodelling to the regulation of inflammation and immune functions. While it is generally accepted that aerobic exercise exerts beneficial effects on several aspects of immune functions, even in older adults, the effect of resistance training remains unclear...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27274758/interleukin-6-and-c-reactive-protein-successful-aging-and-mortality-the-polsenior-study
#7
Monika Puzianowska-Kuźnicka, Magdalena Owczarz, Katarzyna Wieczorowska-Tobis, Pawel Nadrowski, Jerzy Chudek, Przemyslaw Slusarczyk, Anna Skalska, Marta Jonas, Edward Franek, Malgorzata Mossakowska
BACKGROUND: In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for the development of aging-related diseases and frailty. Using data from several thousand Eastern Europeans aged 65 years and older, we investigated whether the serum levels of two proinflammatory factors, interleukin-6 (IL-6) and C-reactive protein (CRP), were associated with physical and cognitive performance, and could predict mortality in successfully aging elderly. RESULTS: IL-6 and CRP levels systematically increased in an age-dependent manner in the entire study group (IL-6: n = 3496 individuals, p < 0...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27247610/the-prognostic-value-of-biomarkers-in-stroke
#8
Francesco Iemolo, Enzo Sanzaro, Giovanni Duro, Antonello Giordano, Maurizio Paciaroni
BACKGROUND: Ischemic injury triggers inflammatory cascades and changes in the protein synthesis, neurotransmitters and neuro-hormones in the brain parenchyma that may further amplify the tissue damage. The "Triage® Stroke Panel", a biochemical multimarker assay, detects Brain Natriuretic Peptide (BNP), D-Dimers (DD), Matrix-Metalloproteinase-9 (MMP-9), and S100β protein generating a Multimarker index of these values (MMX). The aims of this prospective study in consecutive patients with ischemic or hemorrhagic stroke were to assess: 1) the rate of an increase of biomarkers (BNP, D-dimer, MMP-9 and S-100β) tested with the Triage Stroke Panel; 2) the correlation between the increase of these biomarkers and functional outcome at 4 months; 3) the risk factors for the increase of biomarkers...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27239218/role-of-androgens-in-dhea-induced-rack1-expression-and-cytokine-modulation-in-monocytes
#9
Emanuela Corsini, Valentina Galbiati, Angela Papale, Elena Kummer, Antonella Pinto, Melania M Serafini, Antonio Guaita, Roberto Spezzano, Donatella Caruso, Marina Marinovich, Marco Racchi
BACKGROUND: Over the past fifteen years, we have demonstrated that cortisol and dehydroepiandrosterone (DHEA) have opposite effects on the regulation of protein kinase C (PKC) activity in the context of the immune system. The anti-glucocorticoid effect of DHEA is also related to the regulation of splicing of the glucocorticoid receptor (GR), promoting the expression of GRβ isoform, which acts as a negative dominant form on GRα activity. Moreover, it is very well known that DHEA can be metabolized to androgens like testosterone, dihydrotestosterone (DHT), and its metabolites 3α-diol and 3β-diol, which exert their function through the binding of the androgen receptor (AR)...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27213002/nutrigerontology-a-key-for-achieving-successful-ageing-and-longevity
#10
Anna Aiello, Giulia Accardi, Giuseppina Candore, Giuseppe Carruba, Sergio Davinelli, Giuseppe Passarino, Giovanni Scapagnini, Sonya Vasto, Calogero Caruso
During the last two centuries the average lifespan has increased at a rate of approximately 3 months/year in both sexes, hence oldest old people are becoming the population with the fastest growth in Western World. Although the average life expectancy is increasing dramatically, the healthy lifespan is not going at the same pace. This underscores the importance of studies on the prevention of age-related diseases, in order to satisfactorily decrease the medical, economic and social problems associated to advancing age, related to an increased number of individuals not autonomous and affected by invalidating pathologies...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27152115/effects-of-thermal-water-inhalation-in-chronic-upper-respiratory-tract-infections-in-elderly-and-young-patients
#11
Thea Magrone, Mauro Galantino, Nunzio Di Bitonto, Luisella Borraccino, Gerardo Chiaromonte, Emilio Jirillo
BACKGROUND: Chronic upper respiratory tract infections (cURTI) are very frequent illnesses which occur at any age of life. In elderly, cURTI are complicated by immunosenescence, with involvement of lung immune responsiveness. RESULTS: In the present study, 51 elderly (age range: 66-86) and 51 young (age range 24-58) cURTI patients underwent a single cycle (two weeks) of inhalatory therapy with salt-bromide-iodine thermal water in the thermal station "Margherita di Savoia" (Margherita di Savoia, BAT, Italy)...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27134635/the-insulin-receptor-substrate-chico-regulates-antibacterial-immune-function-in-drosophila
#12
Sarah McCormack, Shruti Yadav, Upasana Shokal, Eric Kenney, Dustin Cooper, Ioannis Eleftherianos
BACKGROUND: Molecular and genetic studies in model organisms have recently revealed a dynamic interplay between immunity and ageing mechanisms. In the fruit fly Drosophila melanogaster, inhibition of the insulin/insulin-like growth factor signaling pathway prolongs lifespan, and mutations in the insulin receptor substrate Chico extend the survival of mutant flies against certain bacterial pathogens. Here we investigated the immune phenotypes, immune signaling activation and immune function of chico mutant adult flies against the virulent insect pathogen Photorhabdus luminescens as well as to non-pathogenic Escherichia coli bacteria...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27081392/dietary-phytochemicals-and-neuro-inflammaging-from-mechanistic-insights-to-translational-challenges
#13
REVIEW
Sergio Davinelli, Michael Maes, Graziamaria Corbi, Armando Zarrelli, Donald Craig Willcox, Giovanni Scapagnini
An extensive literature describes the positive impact of dietary phytochemicals on overall health and longevity. Dietary phytochemicals include a large group of non-nutrients compounds from a wide range of plant-derived foods and chemical classes. Over the last decade, remarkable progress has been made to realize that oxidative and nitrosative stress (O&NS) and chronic, low-grade inflammation are major risk factors underlying brain aging. Accumulated data strongly suggest that phytochemicals from fruits, vegetables, herbs, and spices may exert relevant negative immunoregulatory, and/or anti-O&NS activities in the context of brain aging...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27057204/%C3%AE-glucans-ex-vivo-inflammatory-and-oxidative-stress-results-after-pasta-intake
#14
Annalisa Barera, Silvio Buscemi, Roberto Monastero, Calogero Caruso, Rosalia Caldarella, Marcello Ciaccio, Sonya Vasto
BACKGROUND: It is well known that Mediterranean Diet can positively influence the health of each individual, in particular it is know that fibers have an important role. However, in Mediterranean cities most people do not have a close adherence to Mediterranean diet. Thus, in our study, we considered fibers like β-glucans that have been added to pasta with a percentage of 6 %. Our study aimed to evaluate the capacity of β-glucans intake on oxidative stress and inflammation in a cohort of middle aged slightly overweight subjects...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27057203/nutrition-aging-and-cancer-lessons-from-dietary-intervention-studies
#15
REVIEW
Giuseppe Carruba, Letizia Cocciadiferro, Antonietta Di Cristina, Orazia M Granata, Cecilia Dolcemascolo, Ildegarda Campisi, Maurizio Zarcone, Maria Cinquegrani, Adele Traina
There is convincing epidemiological and clinical evidence that, independent of aging, lifestyle and, notably, nutrition are associated with development or progression of major human cancers, including breast, prostate, colorectal tumors, and an increasingly large collection of diet-related cancers. Mechanisms underlying this association are mostly related to the distinct epigenetic effects of different dietary patterns. In this context, Mediterranean diet has been reported to significantly reduce mortality rates for various chronic illnesses, including cardiovascular diseases, neurodegenerative diseases and cancer...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27053941/human-longevity-genetics-or-lifestyle-it-takes-two-to-tango
#16
REVIEW
Giuseppe Passarino, Francesco De Rango, Alberto Montesanto
Healthy aging and longevity in humans are modulated by a lucky combination of genetic and non-genetic factors. Family studies demonstrated that about 25 % of the variation in human longevity is due to genetic factors. The search for genetic and molecular basis of aging has led to the identification of genes correlated with the maintenance of the cell and of its basic metabolism as the main genetic factors affecting the individual variation of the aging phenotype. In addition, studies on calorie restriction and on the variability of genes associated with nutrient-sensing signaling, have shown that ipocaloric diet and/or a genetically efficient metabolism of nutrients, can modulate lifespan by promoting an efficient maintenance of the cell and of the organism...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27053940/nutraceutical-effects-of-table-green-olives-a-pilot-study-with-nocellara-del-belice-olives
#17
Giulia Accardi, Anna Aiello, Valeria Gargano, Caterina Maria Gambino, Santo Caracappa, Sandra Marineo, Gesualdo Vesco, Ciriaco Carru, Angelo Zinellu, Maurizio Zarcone, Calogero Caruso, Giuseppina Candore
BACKGROUND: The aim of this study was to analyse the nutraceutical properties of table green olives Nocellara del Belice, a traditional Mediterranean food. The Mediterranean Diet has as key elements olives and extra virgin olive oil, common to all Mediterranean countries. Olive oil is the main source of fat and can modulate oxidative stress and inflammation, whereas little is known about the role of olives. Moreover, emerging evidences underline the association between gut microbiota and food as the basis of many phenomena that affect health and delay or avoid the onset of some age-related chronic diseases...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27034702/hcv-monoinfection-and-hiv-hcv-coinfection-enhance-t-cell-immune-senescence-in-injecting-drug-users-early-during-infection
#18
Bart P X Grady, Nening M Nanlohy, Debbie van Baarle
BACKGROUND: Injecting drug users (IDU) are at premature risk of developing multimorbidity and mortality from causes commonly observed in the elderly. Ageing of the immune system (immune-senescence) can lead to premature morbidity and mortality and can be accelerated by chronic viral infections. Here we investigated the impact of HCV monoinfection and HIV/HCV coinfection on immune parameters in (ex-) IDU. We analyzed telomere length and expression of activation, differentiation and exhaustion markers on T cells at baseline (t = 1) and at follow-up (t = 2) (median interval 16...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27006681/acute-phase-of-aortic-dissection-a-pilot-study-on-cd40l-mpo-and-mmp-1-2-9-and-timp-1-circulating-levels-in-elderly-patients
#19
E Vianello, E Dozio, R Rigolini, M M Marrocco-Trischitta, L Tacchini, S Trimarchi, M M Corsi Romanelli
BACKGROUND: Acute aortic dissection (AAD) is an event which may be rapidly fatal without early diagnosis and treatment. Aging is one of the main risk factors that could leading to AAD. To date, no specific biomarkers are available to increase the speed of diagnosis. CD40 ligand (CD40L), myeloperoxidase (MPO), matrix metalloproteinase (MMP)-1, -2, -9 and metallopeptidase tissue inhibitor 1 (TIMP-1) are biologically related molecules which integrate inflammation, tissue injury and remodeling, all events associated to AAD...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27006680/antibodies-to-the-dna-directed-rna-polymerase-ii-subunit-rpb1-occur-with-highest-frequency-in-centenarians
#20
Jungwon Han, So-Hyun Park, Dong-Jo Kim, Hyori Kim, Yoon-Ho Choi, Jong-Hyuk Lee, Sang Chul Park, Junho Chung
BACKGROUND: Recently, phage display technology has made it possible to define the circulating repertoire of humoral immunity. This study was designed to define the circulating antibodies specific to centenarians. RESULTS: We used a phage-displayed combinatorial peptide library to screen for peptides (YSATLRY and YSPTLFY) that preferentially react with the IgG fraction of centenarians aged 100-105 years. Centenarian sera binds to YSATLRY and YSPTLFY with higher frequency than that of healthy volunteers aged 60-79 years or healthy volunteers younger than or equal to 43 years of age...
2016: Immunity & Ageing: I & A
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