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Immunity & Ageing: I & A

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https://www.readbyqxmd.com/read/30519273/aged-mice-display-altered-numbers-and-phenotype-of-basophils-and-bone-marrow-derived-basophil-activation-with-a-limited-role-for-aging-associated-microbiota
#1
Adriaan A van Beek, Floris Fransen, Ben Meijer, Paul de Vos, Edward F Knol, Huub F J Savelkoul
Background: The influence of age on basophils is poorly understood, as well as the effect of aging-associated microbiota on basophils. Therefore, we studied the influence of aging and aging-associated microbiota on basophil frequency and phenotype, and differentiation from basophil precursors. Results: Basophils became more abundant in bone marrow (BM) and spleens of 19-month-old mice compared with 4-month-old mice. Aged basophils tended to express less CD200R3 and more CD123, both in BM and spleen...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30479642/different-age-independent-effects-of-nutraceutical-combinations-on-endothelium-mediated-coronary-flow-reserve
#2
Roberta Esposito, Regina Sorrentino, Giuseppe Giugliano, Marisa Avvedimento, Roberta Paolillo, Ciro Santoro, Maria Scalamogna, Mafalda Esposito, Federica Ilardi, Francesco Rozza, Giovanni Esposito, Maurizio Galderisi, Valentina Trimarco
Background: Some components of Nutraceuticals (NUT) such as red yeast rice and Morus alba have demonstrated positive effects on the endothelial function in hypercholesterolemic subjects. Our aim was to compare the effects of two different NUT combinations on cold pressure test (CPT) derived coronary flow reserve (CFR) assessed by transthoracic echo-Doppler. Results: In a randomized, single-blind study, 28 consecutive patients with a variety of cardiovascular risk factors received NUT A (LopiGLIK®: berberine, red yeast rice powder, and leaf extract of Morus alba ) or B (Armolipid Plus®: policosanol, red yeast rice, berberine, astaxantine, folic acidandcoenzyme Q10)...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30479641/effects-of-chocolate-containing-leuconostoc-mesenteroides-strain-ntm048-on-immune-function-a-randomized-double-blind-placebo-controlled-trial
#3
Reiko Kuroda, Hiroaki Higuchi, Keishirou Yoshida, Yasunori Yonejima, Keiko Hisa, Masanori Utsuyama, Kenji Osawa, Katsuiku Hirokawa
Background: Previous reports showed that oral administration of Leuconostoc mesenteroides strain NTM048 increases IgA levels and CD4+ T cell population in feces and mice, respectively, as revealed by flow cytometric analysis of splenocytes. This study aimed to evaluate the effect of chocolate supplemented with L. mesenteroides strain NTM048 (> 1.00 × 109  CFU/day, NTM048) on the immune parameters of healthy subjects, using a randomized, placebo-controlled, double-blinded study design...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30455722/healthy-elderly-singaporeans-show-no-age-related-humoral-hyporesponsiveness-nor-diminished-plasmablast-generation-in-response-to-influenza-vaccine
#4
Xavier Camous, Lucian Visan, Crystal Tan Tze Ying, Brian Abel, Ma Shwe Zin Nyunt, Vipin Narang, Michael Poidinger, Christophe Carre, Sanie Sesay, Nabil Bosco, Nicolas Burdin, Paul Anantharajah Tambyah, Ng Tze Pin, Anis Larbi
Abstract: Improving influenza vaccine efficacy is a priority to reduce the burden of influenza-associated morbidity and mortality. By careful selection of individuals based on health we show sustained response to influenza vaccination in older adults. Sustaining health in aging could be an important player in maintaining immune responses to influenza vaccination. Trial registration: NCT03266237. Registered 30 August 2017, https://clinicaltrials.gov/ct2/show/NCT03266237...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30455721/a-comprehensive-characterization-of-aggravated-aging-related-changes-in-t-lymphocytes-and-monocytes-in-end-stage-renal-disease-the-iesrd-study
#5
Yen-Ling Chiu, Kai-Hsiang Shu, Feng-Jung Yang, Tzu-Ying Chou, Ping-Min Chen, Fang-Yun Lay, Szu-Yu Pan, Cheng-Jui Lin, Nicolle H R Litjens, Michiel G H Betjes, Selma Bermudez, Kung-Chi Kao, Jean-San Chia, George Wang, Yu-Sen Peng, Yi-Fang Chuang
Background: Patients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of the immune system. Nevertheless, the etiology and impact of these changes in ESRD patients remain unknown. Results: Compared to healthy individuals, ESRD patients exhibit accelerated immunosenescence in both T cell and monocyte compartments, characterized by a dramatic reduction in naïve CD4+ and CD8+ T cell numbers but increase in CD8+ TEMRA cell and proinflammatory monocyte numbers...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30450119/association-of-immunoglobulin-gm-allotypes-with-longevity-in-long-living-individuals-from-southern-italy
#6
Annibale A Puca, Anna Ferrario, Anna Maciag, Giulia Accardi, Anna Aiello, Caterina Maria Gambino, Giuseppina Candore, Calogero Caruso, Aryan M Namboodiri, Janardan P Pandey
Background: The aim of this study was to analyse the role of GM allotypes, i.e. the hereditary antigenic determinants expressed on immunoglobulin polypeptide chains, in the attainment of longevity. The role played by immunoglobulin allotypes in the control of immune responses is well known as well as the role of an efficient immune response in longevity achievement. So, it is conceivable that particular GM allotypes may contribute to the generation of an efficient immune response that supports successful ageing, hence longevity...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30450118/genetics-of-exceptional-longevity-possible-role-of-gm-allotypes
#7
EDITORIAL
Calogero Caruso, Janardan P Pandey, Annibale A Puca
No abstract text is available yet for this article.
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30450117/crocetin-attenuates-inflammation-and-amyloid-%C3%AE-accumulation-in-appsw-transgenic-mice
#8
Jin Zhang, Yuchao Wang, Xueshuang Dong, Jianghua Liu
Background: Crocetin, an agent derived from saffron, has multiple pharmacological properties, such as neuroprotective, anti-oxidant, and anti-inflammatory actions. These properties might benefit the treatment of Alzheimer's disease (AD). In the present study, we tested whether crocetin attenuates inflammation and amyloid-β (Aβ) accumulation in APPsw transgenic mice, AD mouse models. Cell viability and the levels of Aβ40 and Aβ42 in HeLa cells stably transfected with Swedish mutant APP751 were evaluated...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30305832/expression-changes-of-autophagy-related-proteins-in-aki-patients-treated-with-crrt-and-their-effects-on-prognosis-of-adult-and-elderly-patients
#9
Yang Zhang, Ling Wang, Lei Meng, Guang-Ke Cao, Yu-Liang Zhao, Yu Wu
Background: Sepsis is one of the common death factors in intensive care unit, which refers to the systemic inflammatory response syndrome caused by infection. It has many complications such as acute renal injury, shock, multiple organ dysfunction, and failure. The mortality of acute renal injury is the highest among the complications, which is a serious threat to the safety of patients and affects the quality of life. This study aimed to observe the changes in autophagy-related protein expressions in patients with acute kidney injury (AKI) after continuous renal replacement therapy (CRRT) and their impacts on prognosis...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30258468/immunosenescence-and-lymphomagenesis
#10
REVIEW
Salvatrice Mancuso, Melania Carlisi, Marco Santoro, Mariasanta Napolitano, Simona Raso, Sergio Siragusa
One of the most important determinants of aging-related changes is a complex biological process emerged recently and called "immunosenescence". Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective response to challenge. This immune dysregulation may manifest as increased susceptibility to infection, cancer, autoimmune disease, and vaccine failure. At present, the relationship between immunosenescence and lymphoma in elderly patients is not defined in a satisfactory way...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30202420/the-baseline-levels-and-risk-factors-for-high-sensitive-c-reactive-protein-in-chinese-healthy-population
#11
Ying Tang, Peifen Liang, Junzhe Chen, Sha Fu, Bo Liu, Min Feng, Baojuan Lin, Ben Lee, Anping Xu, Hui Y Lan
Background: Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CRP in the healthy ageing population remained unclear, which was investigated in the present study. Methods: Serum levels of high sensitive C-reactive protein (hs-CRP), glucose (Glu), triglyceride (TG), cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), superoxide dismutase (SOD), serum creatinine (SCr), serum uric acid (SUA) were measured in 6060healthy subjects (3672 male and 2388 female, mean age:45...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30202419/age-does-not-influence-the-disease-course-in-a-mouse-model-of-streptococcus-pneumoniae-serotype-3-meningitis
#12
Anja Manig, Sandra Ribes, Catharina Diesselberg, Stephanie Bunkowski, Roland Nau, Sandra Schütze
In order to elucidate the causes for the increased mortality of aged patients with bacterial central nervous system (CNS) infections, we compared the course of Streptococcus pneumoniae ( S. pneumoniae ) meningitis in aged and young mice. Aged (21.2 ± 3.1 months, n  = 40) and young (3.2 ± 0.9 months, n  = 42) C57BL/6N and B6/SJL mice were infected by intracerebral injection of 50-70 CFU  S. pneumoniae serotype 3 and monitored for 15 days. Aged and young mice did not differ concerning mortality (35% versus 38%), weight loss, development of clinical symptoms, bacterial concentrations in cerebellum and spleen as well as the number of leukocytes infiltrating the CNS...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30186359/immune-response-to-influenza-vaccination-in-the-elderly-is-altered-by-chronic-medication-use
#13
Divyansh Agarwal, Kenneth E Schmader, Andrew V Kossenkov, Susan Doyle, Raj Kurupati, Hildegund C J Ertl
Background: The elderly patient population is the most susceptible to influenza virus infection and its associated complications. Polypharmacy is common in the aged, who often have multiple co-morbidities. Previous studies have demonstrated that commonly used prescription drugs can have extensive impact on immune defenses and responses to vaccination. In this study, we examined how the dynamics of immune responses to the two influenza A virus strains of the trivalent inactivated influenza vaccine (TIV) can be affected by patient's history of using the prescription drugs Metformin, NSAIDs or Statins...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30166990/correction-to-virtual-memory-cells-make-a-major-contribution-to-the-response-of-aged-influenza-na%C3%A3-ve-mice-to-influenza-virus-infection
#14
Kathleen G Lanzer, Tres Cookenham, William W Reiley, Marcia A Blackman
[This corrects the article DOI: 10.1186/s12979-018-0122-y.].
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30093911/virtual-memory-cells-make-a-major-contribution-to-the-response-of-aged-influenza-na%C3%A3-ve-mice-to-influenza-virus-infection
#15
Kathleen G Lanzer, Tres Cookenham, William W Reiley, Marcia A Blackman
Background: A diverse repertoire of naïve T cells is thought to be essential for a robust response to new infections. However, a key aspect of aging of the T cell compartment is a decline in numbers and diversity of peripheral naïve T cells. We have hypothesized that the age-related decline in naïve T cells forces the immune system to respond to new infections using cross-reactive memory T cells generated to previous infections that dominate the aged peripheral T cell repertoire. Results: Here we confirm that the CD8 T cell response of aged, influenza-naïve mice to primary infection with influenza virus is dominated by T cells that derive from the memory T cell pool...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/30026783/esrd-associated-immune-phenotype-depends-on-dialysis-modality-and-iron-status-clinical-implications
#16
Didier Ducloux, Mathieu Legendre, Jamal Bamoulid, Jean-Michel Rebibou, Philippe Saas, Cécile Courivaud, Thomas Crepin
Background: End-stage renal disease (ESRD) causes premature ageing of the immune system. However, it is not known whether hemodialysis (HD) and peritoneal dialysis (PD) similarly affect the T cell system. Methods: The aim of our study was to analyse whether dialysis modality may mitigate ESRD-induced immune senescence. We explored a large population of patients (675 ESRD patients) and both confirmed and refined the results in a second cohort (84 patients). Results: HD patients exhibited higher inflammatory monocytes counts (44/mm3 (1-520) vs 36/mm3 (1-161); p  = 0...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29988679/anti-cytomegalovirus-igg-antibody-titer-is-positively-associated-with-advanced-t-cell-differentiation-and-coronary-artery-disease-in-end-stage-renal-disease
#17
Feng-Jung Yang, Kai-Hsiang Shu, Hung-Yuan Chen, I-Yu Chen, Fang-Yun Lay, Yi-Fang Chuang, Chien-Sheng Wu, Wan-Chuan Tsai, Yu-Sen Peng, Shih-Ping Hsu, Chih-Kang Chiang, George Wang, Yen-Ling Chiu
Background: Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individuals with normal renal function. Patients with end-stage renal disease (ESRD) exhibit impaired immune function and thus may face higher risk of HCMV-related adverse outcomes. Whether the level of anti-HCMV immune response may be associated with the prognosis of hemodialysis patients is unknown...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29983721/a-study-on-the-relationship-between-waist-phenotype-hypertriglyceridemia-coronary-artery-lesions-and-serum-free-fatty-acids-in-adult-and-elderly-patients-with-coronary-diseases
#18
Rui-Feng Yang, Hanlei Zhang, Zhongchun Wang, Xiao-Yong Liu, Zhi Lin
Background: Abdominal obesity is an independent risk factor for coronary heart disease (CHD) and high serum triglyceride (TG) and free fatty acid levels may precipitate or aggravate CHD. Methods: We enrolled patients with coronary heart disease in our hospital from October 2008 to July 2009. Patients with high TG and increased WC, i.e. waist phenotype WP were included in group A. In group B, were included patients with high TG but not WP. Group C consisted of patients with WP but not high TG...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29755573/thymus-and-activation-regulated-chemokine-tarc-ccl17-and-ige-are-associated-with-elderly-asthmatics
#19
Kyung Mi Jo, Hyo Kyung Lim, Jae Woong Sull, Eugene Choi, Ji-Sook Lee, Mee Ae Cheong, Min Hwa Hong, Yoori Kim, In Sik Kim
Background: The pathogenesis of asthma, which is an allergic lung disease, is associated with a variety of allergens such as house dust mite, pollen, and mould, IgE containing serum IgE and allergen-specific-IgE, and inflammatory cytokines including thymus and activation-regulated chemokine (TARC)/CCL17. Because aging is an essential factor in the pathogenesis of asthma, we examined biomarkers related to asthmatic subjects depending on age. Results: Physiological indices such as FEV1(forced expiratory capacity in 1 s), FEV1 (% predicted), and FEV1/FVC(forced vital capacity) (%) in asthmatic subjects were lower than those in normal subjects...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29541147/nk-cells-of-the-oldest-seniors-represent-constant-and-resistant-to-stimulation-high-expression-of-cellular-protective-proteins-sirt1-and-hsp70
#20
Lucyna Kaszubowska, Jerzy Foerster, Jan Jacek Kaczor, Daria Schetz, Tomasz Jerzy Ślebioda, Zbigniew Kmieć
Background: Natural killer cells (NK cells) are cytotoxic lymphocytes of innate immunity that reveal some immunoregulatory properties, however, their role in the process of ageing is not completely understood. The study aimed to analyze the expression of proteins involved in cellular stress response: sirtuin 1 (SIRT1), heat shock protein 70 (HSP70) and manganese superoxide dismutase (SOD2) in human NK cells with reference to the process of ageing. Non-stimulated and stimulated with IL-2, LPS or PMA with ionomycin cells originated from peripheral blood samples of: seniors aged over 85 ('the oldest'; n  = 25; 88...
2018: Immunity & Ageing: I & A
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