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Pharmacological Reports: PR

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https://www.readbyqxmd.com/read/28400086/corrigendum-to-epicutaneous-immunization-with-protein-antigen-tnp-ig-alleviates-tnbs-induced-colitis-in-mice-pharmacol-rep-64-2012-1497-1504
#1
Monika Majewska-Szczepanik, Marta Góralska, Katarzyna Marcińska, Magdalena Zemelka-Wiącek, Anna Strzępa, Iwona Dorożyńska, Marian Szczepanik
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28373019/corrigendum-to-inhibition-of-2-4-dinitrofluorobenzene-induced-contact-hypersensitivity-reaction-by-antidepressant-drugs-pharmacol-rep-65-2013-1237-1246
#2
Katarzyna Curzytek, Marta Kubera, Monika Majewska-Szczepanik, Marian Szczepanik, Katarzyna Marcińska, Włodzimierz Ptak, Weronika Duda, Monika Leśkiewicz, Agnieszka Basta-Kaim, Bogusława Budziszewska, Władysław Lasoń, Michael Maes
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28373018/corrigendum-to-metformin-has-adenosine-monophosphate-activated-protein-kinase-ampk-independent-effects-on-lps-stimulated-rat-primary-microglial-cultures-pharmacol-rep-62-2010-827-848
#3
Krzysztof Łabuzek, Sebastian Liber, Bożena Gabryel, Bogusław Okopień
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28365259/corrigendum-to-comparison-of-chosen-activation-markers-of-human-monocytes-macrophages-isolated-from-the-peripheral-blood-of-young-and-elderly-volunteers-pharmacol-rep-66-2014-759-765
#4
Dariusz Suchy, Krzysztof Łabuzek, Łukasz Bułdak, Dawid Szkudłapski, Bogusław Okopień
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28365258/corrigendum-to-eplerenone-promotes-alternative-activation-in-human-monocyte-derived-macrophages-pharmacol-rep-65-2013-226-234
#5
Krzysztof Łabuzek, Sebastian Liber, Łukasz Bułdak, Grzegorz Machnik, Justyna Liber, Bogusław Okopień
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28365257/corrigendum-to-epicutaneous-immunization-with-phosphorylcholine-conjugated-to-bovine-serum-albumin-pc-bsa-and-tlr9-ligand-cpg-alleviates-pneumococcal-pneumonia-in-mice-pharmacol-rep-66-2014-570-575
#6
Monika Majewska-Szczepanik, Natsuo Yamamoto, Philip W Askenase, Marian Szczepanik
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28365256/corrigendum-to-epicutaneous-immunization-with-protein-antigen-tnp-ig-and-nod2-ligand-muramyl-dipeptide-mdp-reverses-skin-induced-suppression-of-contact-hypersensitivity-pharmacol-rep-66-2014-137-142
#7
Monika Majewska-Szczepanik, Iwona Dorożyńska, Anna Strzępa, Marian Szczepanik
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28365255/corrigendum-to-oral-treatment-with-enrofloxacin-early-in-life-promotes-th2-mediated-immune-response-in-mice-pharmacol-rep-68-2016-44-50
#8
Anna Strzępa, Monika Majewska-Szczepanik, Paulina Kowalczyk, Dorota Woźniak, Sylwia Motyl, Marian Szczepanik
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28364698/n-heterocyclic-choline-analogues-based-on-1-2-3-4-tetrahydro-iso-quinoline-scaffold-with-anticancer-and-anti-infective-dual-action
#9
Alla Zablotskaya, Izolda Segal, Athina Geronikaki, Irina Shestakova, Vizma Nikolajeva, Galina Makarenkova
BACKGROUND: Pharmacological effects of biologically active "small molecules" can be improved by their targeted modification, which affects drug delivery and interaction with tumor cells and microorganisms. We aimed to evaluate anticancer and antimicrobial activity of lipid-like choline derivatives modified via simultaneous introduction of tetrahydro(iso)quinoline based pharmacophore system at nitrogen atom and long chain alkyl substituent at oxygen atom. METHODS: Target compounds were synthesized under phase-transfer catalysis conditions followed by quaternization, and evaluated for cytotoxicity and NO-generation ability on HT-1080 and MG-22A tumor cell lines and NIH 3T3 normal mouse fibroblasts, and screened for antimicrobial activity against gram-positive (Staphylococcus aureus and Bacillus cereus) and gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa and Proteus mirabilis) and fungi (Candida albicans and Aspergillus niger)...
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28364697/antidepressant-like-effect-of-1-2-3-4-tetrahydroisoquinoline-and-its-methyl-derivative-in-animal-models-of-depression
#10
Edyta Możdżeń, Agnieszka Wąsik, Irena Romańska, Jerzy Michaluk, Lucyna Antkiewicz-Michaluk
BACKGROUND: Most of the currently used antidepressant drugs are monoamine-based compounds, acting by the inhibition of re-uptake or metabolism of noradrenaline (NA) and/or serotonin (5-HT), because these neurotransmitters play a key role in the pathophysiology of depression. The aim of this study was to investigate the potential antidepressant-like activity of an endogenous amine, 1,2,3,4-tetrahydroisoquinoline (TIQ) and its close derivative, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ)...
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28364696/differential-effects-of-liver-steatosis-on-pharmacokinetic-profile-of-two-closely-related-hepatoselective-no-donors-v-pyrro-no-and-v-proli-no
#11
Kamil Kus, Edyta Kus, Agnieszka Zakrzewska, Wojciech Jawien, Barbara Sitek, Maria Walczak, Stefan Chlopicki
PURPOSE: To analyze the effect of liver steatosis and obesity on pharmacokinetic profile of two structurally-related liver-selective NO-donors - V-PYRRO/NO and V-PROLI/NO. METHODS: C57BL/6 mice were fed control or high-fat diet for 15 weeks to induced liver steatosis and obesity (HFD mice). Pharmacokinetics and renal elimination studies were conducted in vivo following iv dosing of V-PYRRO/NO and V-PROLI/NO (0.03mmol/kg). Hepatic clearance was evaluated ex vivo in the isolated perfused mice liver and in vitro with the use of liver microsomes...
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28364695/the-influence-of-a-single-and-chronic-administration-of-venlafaxine-on-tramadol-pharmacokinetics-in-a-rabbit-model
#12
Danuta Szkutnik-Fiedler, Tomasz Grabowski, Monika Balcerkiewicz, Michał Michalak, Irina Pilipczuk, Łukasz Wyrowski, Hanna Urjasz, Edmund Grześkowiak
BACKGROUND: The combined use of tramadol with selective serotonin and norepinephrine reuptake inhibitors e.g. venlafaxine may be associated with serotonin syndrome. No previous studies exist examining the influence of a weak CYP2D6 inhibitor venlafaxine on the pharmacokinetics of tramadol. Therefore, the aim of this study was to determine the effect of a single and chronic administration of venlafaxine on the pharmacokinetics of tramadol using a rabbit model. METHODS: Adult New Zealand white rabbits of both sexes (n=21) were used...
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28364694/the-role-of-melatonin-neurokinin-neurotrophic-tyrosine-kinase-and-glucocorticoid-receptors-in-antidepressant-like-effect
#13
REVIEW
Karolina Pytka, Katarzyna Młyniec, Karolina Podkowa, Adrian Podkowa, Magdalena Jakubczyk, Elżbieta Żmudzka, Klaudia Lustyk, Jacek Sapa, Barbara Filipek
Over the last few decades, depression has become one of the major public health problems in our society. This problem is connected not only with morbidity, but also with treatment, specifically with the effectiveness of the therapy as well as the concomitant side effects of available antidepressants. Major depressive disorder is a complex clinical entity, including different molecular mechanisms and neurological processes. This complexity is a challenge for scientists seeking to discover an innovatory antidepressant drug with multiple and complementary mechanisms of action...
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28364693/the-%C3%AF-1-receptor-agonist-pentazocine-increases-store-operated-ca-2-entry-in-mcf7%C3%AF-1-and-sk-n-sh-cell-lines
#14
Giuseppe Gasparre, Carmen Abate, Roberto Carlucci, Francesco Berardi, Giuseppe Cassano
BACKGROUND: The intracellular [Ca(2+)] is modulated by σ receptors. An important component of the cellular machinery governing the intracellular [Ca(2+)] is Store-Operated Calcium Entry (SOCE). Here we want to investigate whether ligands of σ receptors affect SOCE. METHODS: The intracellular [Ca(2+)] was monitored, with the fluorescent Ca(2+)-sensitive probe Fura-2, in four cell lines with a different expression of σ receptors, namely MCF7 (expressing σ1 receptors with a low density and overexpressing σ2 receptors), MCF7σ1 (overexpressing σ1 receptors), SK-N-SH, and HT-29...
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28364692/the-effect-of-three-angiotensin-converting-enzyme-inhibitors-on-kynurenic-acid-production-in-rat-kidney-in-vitro
#15
Izabela Zakrocka, Tomasz Kocki, Waldemar A Turski
BACKGROUND: The renin-angiotensin system (RAS) is commonly known to regulate blood pressure, water and electrolyte homeostasis, however it also exerts paracrine and autocrine actions on the kidney. Angiotensin-converting enzyme inhibitors (ACE-Is), alongside their hypotensive properties, have been shown to decrease kidney function decline in animal models of nephropathy. Glutamate (GLU) is the main stimulatory neurotransmitter in the central nervous system, however its importance in the periphery should also be considered...
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28363501/corrigendum-to-partial-depletion-of-natural-gut-flora-by-antibiotic-aggravates-collagen-induced-arthritis-cia-in-mice-pharmacol-rep-66-2014-250-255
#16
Iwona Dorożyńska, Monika Majewska-Szczepanik, Katarzyna Marcińska, Marian Szczepanik
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28363500/corrigendum-to-metformin-affects-macrophages-phenotype-and-improves-the-activity-of-glutathione-peroxidase-superoxide-dismutase-catalase-and-decreases-malondialdehyde-concentration-in-a-partially-ampk-independent-manner-in-lps-stimulated-human-monocytes-macrophages
#17
Łukasz Bułdak, Krzysztof Łabuzek, Rafał Jakub Bułdak, Michał Kozłowski, Grzegorz Machnik, Sebastian Liber, Dariusz Suchy, Anna Duława-Bułdak, Bogusław Okopień
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28363184/treatment-with-platelet-derived-growth-factor-pdgf-and-rock-inhibitors-is-related-to-declined-nerve-growth-factor-ngf-signaling-in-an-experimental-model-of-rat-pulmonary-hypertension
#18
Magdalena Jasińska-Stroschein, Katarzyna Oszajca, Weronika Świtlik, Justyna Ruchwa, Daria Orszulak-Michalak
BACKGROUND: Recent studies reveal that nerve growth factor (NGF) plays a critical role in the pathobiology of pulmonary hypertension (PH). The aim of the present study is to clarify the relationship between NGF signaling and treatment with PDGF or ROCK inhibitors in an animal model of PH. METHODS: Lung tissues were obtained from animals with monocrotaline (MCT)-challenged PH which had been administered long term imatinib, fasudil or statin. Reversal of disease was indicated by decreases in right ventricle pressure (RVP) and hypertrophy...
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28359919/the-role-of-transient-receptor-potential-vanilloid-type-1-in-unimodal-and-multimodal-object-recognition-task-in-rats
#19
Mahboobeh Bannazadeh, Farangis Fatehi, Iman Fatemi, Ali Roohbakhsh, Mohammad Allahtavakoli, Mahin Nasiri, Mahdieh Azin, Ali Shamsizadeh
BACKGROUND: The role of transient receptor potential vanilloid type 1 (TRPV1) channels in learning and memory processes has recently been recognized. In the present study, the role of this receptor in the multisensory integration process was investigated. METHODS: This study was done using 96 male Wistar rats, which were kept in a reverse 12-12h dark/light cycle. Unimodal and multimodal object recognition task was performed by four variations of the spontaneous object recognition (SOR) test including standard SOR, tactile SOR, visual SOR, and cross-modal visual-tactile SOR (CMOR)...
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28359918/the-effects-of-desipramine-fluoxetine-or-tianeptine-on-changes-in-bulbar-bdnf-levels-induced-by-chronic-social-instability-stress-and-inflammation
#20
Marta M Nowacka-Chmielewska, Daniela Kasprowska, Monika Paul-Samojedny, Anna M Bielecka-Wajdman, Jarosław J Barski, Andrzej Małecki, Ewa Obuchowicz
BACKGROUND: Stress is a major predisposing factor in the development of psychiatric disorders and potential source of augmented inflammatory processes in the brain. Increasing body of evidence shows an important role of alterations in the olfactory bulbs (OBs) function in stress-related disorders. The aim of the present study was to investigate the impact of antidepressants on the alterations of brain-derived neurotrophic factor (BDNF) induced by lipopolysaccharide (LPS) in female rats subjected to chronic social instability stress (CSIS)...
June 2017: Pharmacological Reports: PR
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