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Pharmacological Reports: PR

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https://www.readbyqxmd.com/read/28623709/the-mechanism-of-neuroprotective-action-of-natural-compounds
#1
REVIEW
Agnieszka Wąsik, Lucyna Antkiewicz-Michaluk
Disturbance of cerebral redox homeostasis is the primary cause of human neurodegenerative disorders, such as Parkinson's disease or Alzheimer's disease. Well known experimental research demonstrates that oxidative stress is a main cause of cell death. A high concentration of reactive oxygen and nitrogen species leads to damage of a lot of proteins, lipids and also DNA. Synthetic compounds used for the treatment in the neurodegenerative diseases failed to meet the hopes they had raised and often exhibit a number of side effects...
April 30, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28623712/deoxypodophyllotoxin-induces-cytoprotective-autophagy-against-apoptosis-via-inhibition-of-pi3k-akt-mtor-pathway-in-osteosarcoma-u2os-cells
#2
Sang-Hun Kim, Kyo-Min Son, Kwang-Youn Kim, Sun-Nyoung Yu, Sul-Gi Park, Young-Wook Kim, Hyo-Won Nam, Jeung-Tak Suh, Jae-Hoon Ji, Soon-Cheol Ahn
BACKGROUND: A natural compound deoxypodophyllotoxin (DPT) possesses potent anti-proliferative and anti-tumor properties on several cancer types. It triggers cell cycle arrest followed by apoptosis through various cellular processes. However, it is limited to the action mechanism of DPT-mediated cell death modes via apoptosis and autophagy. METHODS: Cell viability assay, morphological changes, annexin-V/propidium iodide (PI) assay, reactive oxygen species (ROS), acridine orange staining, and Western blot analyses were evaluated...
April 13, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28628850/indoline-derivatives-mitigate-liver-damage-in-a-mouse-model-of-acute-liver-injury
#3
Efrat Finkin-Groner, Shlomi Finkin, Shani Zeeli, Marta Weinstock
BACKGROUND: Exposure of mice to D-galactosamine (GalN) and lipopolysaccharide (LPS) induces acute liver failure through elevation of TNF-α, which causes liver damage resembling that in humans. The current study evaluated in this model the effect of two indoline derivatives, which have anti-inflammatory activity in macrophages. METHODS: AN1297 and AN1284 (0.025-0.75mg/kg) or dexamethasone (3mg/kg), were injected subcutaneously, 15min before intraperitoneal injection of GalN (800mg) plus LPS (50μg) in male Balb/C mice...
April 12, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28624597/suppressive-effect-of-kamebakaurin-on-acetaminophen-induced-hepatotoxicity-by-inhibiting-lipid-peroxidation-and-inflammatory-response-in-mice
#4
Hiroki Yoshioka, Yutaka Aoyagi, Nobuyuki Fukuishi, Ming-Yu Gui, Yong-Ri Jin, Xu-Wen Li, Yoshiyuki Adachi, Naohito Ohno, Koichi Takeya, Yukio Hitotsuyanagi, Nobuhiko Miura, Tsunemasa Nonogaki
BACKGROUND: Kamebakaurin (KA) is an ent-kaurane diterpenoid known to have anti-inflammatory potential. In the current study, we investigated whether pretreatment with KA could ameliorate acetaminophen (APAP)-induced hepatotoxicity by inhibiting the anti-inflammatory response in mice. METHODS: Seven-week-old C57BL/6J mice were orally administered KA or olive oil emulsion for seven days. Twenty-four hours after the last KA or olive oil administration, the mice were intraperitoneally injected with 400mg/kg APAP or saline under feed deprived condition...
April 12, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28582691/biological-functions-and-role-of-mitogen-activated-protein-kinase-activated-protein-kinase-2-mk2-in-inflammatory-diseases
#5
REVIEW
Rakesh Kumar Singh, Abul Kalam Najmi, Sunanda Ghosh Dastidar
The p38/MK2 pathway regulates a wide range of biological functions, and thus has most been explored as a therapeutic target for inhibition of severe and chronic inflammatory diseases. Till date, several p38 inhibitors with potent anti-inflammatory effects in pre-clinical models have been discovered, but most of them have failed in clinics due to serious systemic toxicity issues. MK2 is a serine-threonine kinase downstream to p38 and is activated directly through phosphorylation of p38 under stress and inflammatory stimulus...
April 8, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28605700/a-novel-resveratrol-salinomycin-combination-sensitizes-er-positive-breast-cancer-cells-to-apoptosis
#6
Rajkumar Venkatadri, Anand Krishnan V Iyer, Vivek Kaushik, Neelam Azad
BACKGROUND: Resveratrol is a dietary compound that has been widely reported for its anticancer activities. However, successful extrapolation of its effects to pre-clinical studies is met with limited success due to inadequate bioavailability. We investigated the potential of combination therapy to improve the efficacy of resveratrol in a more physiologically relevant dose range. METHODS: The effect of resveratrol on canonical Wnt signaling was evaluated by Western blotting...
April 7, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28624598/inhibition-of-lps-induced-pro-inflammatory-responses-in-raw-264-7-macrophage-cells-by-pvp-coated-naringenin-nanoparticle-via-down-regulation-of-nf-%C3%AE%C2%BAb-p38mapk-mediated-stress-signaling
#7
Pradeep Kumar R, Annie Abraham
BACKGROUND: Naringenin (NAR) was found to display strong pharmacological properties. Since the clinical relevance of NAR is limited by its low bioavailability, we effectively synthesized and characterized a novel PVP-coated NAR nanoparticle (NAR NP) to enhance the therapeutic efficacy of NAR. The present study was designed to investigate the effects of NAR NP on lipopolysaccharide (LPS) induced inflammatory response in RAW 264.7 macrophage cells. METHODS: In vitro cell culture studies of LPS stimulated RAW 264...
April 6, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28628851/spinal-5-ht4-and-5-ht6-receptors-contribute-to-the-maintenance-of-neuropathic-pain-in-rats
#8
Jorge Baruch Pineda-Farias, Paulino Barragán-Iglesias, Alann Valdivieso-Sánchez, Juan Rodríguez-Silverio, Francisco Javier Flores-Murrieta, Vinicio Granados-Soto, Héctor Isaac Rocha-González
BACKGROUND: Nerve injury promotes release of 5-HT at the spinal cord. Once released, 5-HT may produce antinociceptive or pronociceptive effects depending of the nature of 5-HT receptors. The purpose of this study was to investigate the participation of spinal 5-HT4 and 5-HT6 receptors in the maintenance of neuropathic pain in rats. METHODS: Tactile allodynia was measured using von Frey hairs in male Wistar rats subjected to L5-L6 spinal nerve injury. Selective 5-HT4 (GR-113808, 0...
April 4, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28577450/n-acetylcysteine-induced-vasodilatation-is-modulated-by-katp-channels-na-k-atpase-activity-and-intracellular-calcium-concentration-an-in-vitro-study
#9
Özden Vezir, Ülkü Çömelekoğlu, Nehir Sucu, Ali Erdinç Yalın, Şakir Necat Yılmaz, Serap Yalın, Fatma Söğüt, Selma Yaman, Kezban Kibar, Merih Akkapulu, Meryem İlkay Koç, Didem Seçer
BACKGROUND: In this study, we aimed to investigate the role of ATP-sensitive potassium (KATP) channel, Na(+)/K(+)-ATPase activity, and intracellular calcium levels on the vasodilatory effect of N-acetylcysteine (NAC) in thoracic aorta by using electrophysiological and molecular techniques. METHODS: Rat thoracic aorta ring preparations and cultured thoracic aorta cells were divided into four groups as control, 2mM NAC, 5mM NAC, and 10mM NAC. Thoracic aorta rings were isolated from rats for measurements of relaxation responses and Na(+)/K(+)-ATPase activity...
March 31, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28623708/isobolographic-analysis-of-the-cutaneous-antinociceptive-interaction-between-bupivacaine-co-injected-with-serotonin-in-rats
#10
Jann-Inn Tzeng, Chong-Chi Chiu, Jhi-Joung Wang, Yu-Wen Chen, Ching-Hsia Hung
BACKGROUND: The aim of this experiment was to investigate a long-lasting local anesthetic bupivacaine combined with serotonin at inducing cutaneous antinociception. METHODS: The skin antinociception, characterized by an inhibition of the cutaneous trunci muscle reflex (CTMR) following the pinprick on the dorsal skin of rats, was evaluated. The cutaneous antinociceptive effects of bupivacaine alone, serotonin alone, or bupivacaine co-injected with serotonin in a dose-dependent fashion were constructed, while the drug-drug interactions were evaluated by isobologram...
March 29, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28623711/contribution-of-dopaminergic-and-noradrenergic-systems-in-the-antinociceptive-effect-of-%C3%AE-phenylalanyl-acetophenone
#11
Fernanda S S Sousa, Roberta G Anversa, Paloma T Birmann, Maurice N de Souza, Renata Balaguez, Diego Alves, Cristiane Luchese, Ethel A Wilhelm, Lucielli Savegnago
BACKGROUND: This study evaluated the antinociceptive action of α-(phenylalanyl) acetophenone (PSAP) in mice. METHODS: Evaluated whether the serotonergic, adrenergic and dopaminergic systems are involved in PSAP antinociceptive activity. PSAP was administered intragastrically (ig) 30min prior to formalin or glutamate test and compared with a standard drug, meloxicam (10mg/kg, ig). RESULTS: The treatment with PSAP (10-50mg/kg) caused inhibition in the neurogenic phase and reduced the paw oedema caused by intraplantar (ipl) injection of formalin...
March 27, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28623707/the-role-of-pon-1-gr-il-18-and-oxldl-in-depression-with-and-without-posttraumatic-stress-disorder
#12
Ewa A Ogłodek
BACKGROUND: Both oxidative stress markers and inflammatory markers are important when diagnosing depression. Oxidative stress occurs due to an imbalance between free radical generation and antioxidant potential. Both adenosine triphosphate and reactive oxygen/nitrogen species are released during oxidative phosphorylation. When neuroinflammation and free radical production are increased, oxidative stress occurs and causes damage to all major cellular macromolecules. The aim of the study was to compare the concentrations of paraoxonase-1 (PON-1), glutathione reductase (GR), interleukin-18 (IL-18), and oxidized low-density lipoproteins (OxLDL) in depressed patients with and without posttraumatic stress disorder (PTSD), and PTSD alone...
March 27, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28400086/corrigendum-to-epicutaneous-immunization-with-protein-antigen-tnp-ig-alleviates-tnbs-induced-colitis-in-mice-pharmacol-rep-64-2012-1497-1504
#13
Monika Majewska-Szczepanik, Marta Góralska, Katarzyna Marcińska, Magdalena Zemelka-Wiącek, Anna Strzępa, Iwona Dorożyńska, Marian Szczepanik
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28373019/corrigendum-to-inhibition-of-2-4-dinitrofluorobenzene-induced-contact-hypersensitivity-reaction-by-antidepressant-drugs-pharmacol-rep-65-2013-1237-1246
#14
Katarzyna Curzytek, Marta Kubera, Monika Majewska-Szczepanik, Marian Szczepanik, Katarzyna Marcińska, Włodzimierz Ptak, Weronika Duda, Monika Leśkiewicz, Agnieszka Basta-Kaim, Bogusława Budziszewska, Władysław Lasoń, Michael Maes
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28373018/corrigendum-to-metformin-has-adenosine-monophosphate-activated-protein-kinase-ampk-independent-effects-on-lps-stimulated-rat-primary-microglial-cultures-pharmacol-rep-62-2010-827-848
#15
Krzysztof Łabuzek, Sebastian Liber, Bożena Gabryel, Bogusław Okopień
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28365259/corrigendum-to-comparison-of-chosen-activation-markers-of-human-monocytes-macrophages-isolated-from-the-peripheral-blood-of-young-and-elderly-volunteers-pharmacol-rep-66-2014-759-765
#16
Dariusz Suchy, Krzysztof Łabuzek, Łukasz Bułdak, Dawid Szkudłapski, Bogusław Okopień
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28365258/corrigendum-to-eplerenone-promotes-alternative-activation-in-human-monocyte-derived-macrophages-pharmacol-rep-65-2013-226-234
#17
Krzysztof Łabuzek, Sebastian Liber, Łukasz Bułdak, Grzegorz Machnik, Justyna Liber, Bogusław Okopień
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28365257/corrigendum-to-epicutaneous-immunization-with-phosphorylcholine-conjugated-to-bovine-serum-albumin-pc-bsa-and-tlr9-ligand-cpg-alleviates-pneumococcal-pneumonia-in-mice-pharmacol-rep-66-2014-570-575
#18
Monika Majewska-Szczepanik, Natsuo Yamamoto, Philip W Askenase, Marian Szczepanik
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28365256/corrigendum-to-epicutaneous-immunization-with-protein-antigen-tnp-ig-and-nod2-ligand-muramyl-dipeptide-mdp-reverses-skin-induced-suppression-of-contact-hypersensitivity-pharmacol-rep-66-2014-137-142
#19
Monika Majewska-Szczepanik, Iwona Dorożyńska, Anna Strzępa, Marian Szczepanik
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28365255/corrigendum-to-oral-treatment-with-enrofloxacin-early-in-life-promotes-th2-mediated-immune-response-in-mice-pharmacol-rep-68-2016-44-50
#20
Anna Strzępa, Monika Majewska-Szczepanik, Paulina Kowalczyk, Dorota Woźniak, Sylwia Motyl, Marian Szczepanik
No abstract text is available yet for this article.
June 2017: Pharmacological Reports: PR
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