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Journal of Opioid Management

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https://www.readbyqxmd.com/read/28059434/assessment-of-abuse-liability-of-tramadol-among-experienced-drug-users-double-blind-crossover-randomized-controlled-trial
#1
Mrinmay Das, Raka Jain, Anju Dhawan, Amandeep Kaur
BACKGROUND: Tramadol is a widely used opioid analgesic. Different preclinical, clinical, and postmarketing surveillance studies show conflicting results regarding abuse potential of this drug. METHODS: A randomized double-blind complete crossover study was conducted at National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi. Total subjects were 10, comprising total 120 observations (each subject assessed at baseline, 5, 45, and 240 minutes)...
November 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/28059433/a-12-week-extension-study-to-assess-the-safety-and-tolerability-of-naloxegol-in-patients-with-noncancer-pain-and-opioid-induced-constipation
#2
Lynn Webster, Raj Tummala, Ulysses Diva, Jaakko Lappalainen
OBJECTIVE: To compare the long-term safety and tolerability of naloxegol with placebo in patients with opioid-induced constipation (OIC) and noncancer pain. DESIGN: Twelve-week, multicenter, randomized, double-blind, parallel-group phase 3 extension study (KODIAC-07, NCT01395524). SETTING: Clinical investigation centers in the United States. PATIENTS: Adult outpatients (N = 302) with confirmed OIC who had completed a 12-week pivotal phase 3 study (KODIAC-04, NCT01309841)...
November 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/28059432/primary-care-providers-prescribing-practices-of-opioid-controlled-substances
#3
Lisa B E Shields, Soraya Nasraty, Alisha D Bell, Anil N Vinayakan, Raghunath S Gudibanda, Steven T Hester, Joshua T Honaker
OBJECTIVE: Prescription opioid abuse poses a significant public health concern. House Bill 1 (HB1) was enacted in 2012 to address prescription drug abuse in Kentucky. The authors investigated the impact of HB1 on primary care providers' (PCPs) prescribing practices of Schedule II controlled substances. DESIGN: Retrospective evaluation of PCPs' prescribing practices in an adult outpatient setting. METHODS: A review of the prescribing practices for Schedule II controlled substances written by 149 PCPs...
November 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/28059431/evaluation-of-treatment-changes-following-electronic-consultation-to-a-pharmacist-run-urine-drug-testing-service-in-a-veterans-healthcare-system
#4
Michelle M Stammet, Shelley S Spradley
In 2013, the North Florida/South Georgia Veterans Healthcare System established a pharmacist-run urine drug testing (UDT) electronic consultation (e-consult) service to assist providers with interpretation of this useful yet complex clinical tool. This pilot study aimed to classify clinical treatment changes implemented following e-consult to a pharmacist-run UDT service and analyze factors limiting pharmacist intervention postconsultation. One hundred forty-three e-consults were completed in the 2-year study period including interpretation of 190 UDT results classified as expected, unexpected, or not necessarily inappropriate based on prescription profile at time of urine immunoassay test...
November 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/28059430/attitudes-toward-the-canadian-guideline-for-safe-and-effective-use-of-opioids-for-chronic-non-cancer-pain-a-qualitative-study
#5
Yaping Chang, Kan Lun Zhu, Ivan D Florez, Sung Min Cho, Nasim Zamir, Augustin Toma, Reza Donald Mirza, Gordon H Guyatt, Norman Buckley, Jason W Busse
BACKGROUND: Chronic noncancer pain (CNCP) refers to all pain disorders, not due to cancer, that persist for ≥3 months. The point prevalence of CNCP in the general population of Western countries is between 19 and 33 percent. Opioids are commonly prescribed for CNCP and are associated with both benefits and harms. The Canadian Guideline for Safe and Effective Use of Opioids for CNCP was published in 2010 to provide guidance for optimal opioid prescribing in patients with CNCP. OBJECTIVES: To investigate the attitudes toward, and use of, the Canadian Opioids Guideline among pain physicians...
November 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27844476/coprescribing-naloxone-for-patients-on-chronic-opioid-therapy-les-sons-learned-from-a-patient-safety-initiative-in-primary-care-training-sites
#6
William Delaney, Jessica Huff, Sandra Mini, Aiswarya Thomas, Ralph Tremaglio
OBJECTIVE: To describe the development and implementation of a resident-led effort to increase coprescription of naloxone in a primary care setting. DESIGN: An exploratory, prospective pilot project to increase coprescription rates of naloxone. SETTING: Four primary care offices in western Connecticut serving as medical home training sites for primary care residents. PATIENTS, PARTICIPANTS: All patients on chronic opioid therapy...
September 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27844475/rhode-island-board-of-medical-licensure-and-discipline-illustration-of-the-disciplinary-process-as-it-pertains-to-cases-involving-opioid-prescribing
#7
James V McDonald
Prescription-drug overuse/overdose and misuse is an important and pivotal issue to state medical boards. This is an illustration of how some cases involving overprescribing of opioids have been addressed by the Rhode Island Board of Medical Licensure and Discipline.
September 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27844474/assessment-of-acute-pain-in-trauma-a-retrospective-prehospital-evaluation
#8
Stine Hebsgaard, Anne Mannering, Stine T Zwisler
OBJECTIVE: To elucidate pain treatment with analgesics in a prehospital trauma population. DESIGN: Retrospective database study. SETTING: Prehospital data from the anesthesiologist-manned Mobile Emergency Care Unit (MECU) in Odense, Denmark, were extracted and subjected to analysis. PATIENTS: During the period of January 1, 2013 to December 31, 2014, patients with the diagnoses "unspecified multiple injuries," "examination and observation following traffic accident," "examination and observation following other accident," and "commotio cerebri" were included in the analysis...
September 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27844473/adherence-to-chronic-opioid-therapy-prescribing-guidelines-in-a-primary-care-clinic
#9
Cynthia Kay, Erica Wozniak, Sarah Koller, Audrey Ye, Joanne Bernstein
OBJECTIVE: Characterize primary care patients prescribed opioids for chronic noncancer pain (CNCP), explore guideline-recommended opioid-monitoring practices, and investigate predictors of pain agreements. DESIGN: Retrospective chart review. SETTING: Primary care clinic at a tertiary academic medical center. PATIENTS: Adults prescribed chronic opioids (three or more monthly prescriptions within a year) for CNCP between April 1, 2014 and April 1, 2015...
September 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27844472/patient-relevant-outcomes-and-health-related-quality-of-life-in-patients-with-chronic-severe-noncancer-pain-treated-with-tapentadol-prolonged-release-using-criteria-of-health-technology-assessment
#10
Johannes Fx Hofmann, Arun Lal, Maike Steffens, Robert Boettger
OBJECTIVE: To perform a systematic comparison of tapentadol prolonged release (PR) and oxycodone controlled release (CR) using patient-relevant endpoints of efficacy, safety, and health-related quality of life (HRQoL) according to criteria used in health technology assessment. To derive a minimal important difference (MID) for the EQ-5D from three pivotal trials to measure patient-relevant changes in HRQoL. DESIGN: Randomized, double-blind, placebo and active controlled...
September 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27844471/clinically-relevant-concentrations-of-opioids-for-in-vitro-studies
#11
Jason W Boland, A Graham Pockley
OBJECTIVES: Numerous in vitro studies have evaluated the influence of opioids on many biological and immunological processes. The concentrations that have been used in these studies span a large range and often do not reflect levels that are present in the relevant patient groups. This article reviews the literature concerning the concentrations of opioids that are detected in patients so that the concentrations of opioids that are used for in vitro studies can better reflect those that are present clinically...
September 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27844470/transient-low-testosterone-levels-after-oral-hydrocodone-may-contribute-to-misdiagnosis-of-hypogonadism
#12
Harry W Daniell
CONTEXT: Multiple morning testosterone levels are needed to establish the presence of male hypogonadism and to justify its replacement therapy. Any influence on these levels by short-term opioid ingestion has not, however, been reported. CASE DESCRIPTION: Serial testosterone levels are reported at 2-hour intervals once weekly for 22 weeks in a man after his ingestion of 0, 5, or 10 mg of hydrocodone. CONCLUSIONS: Five milligrams of hydrocodone did not significantly alter postingestion testosterone levels, but 10 mg ingestion lowered them at 2, 4, and 6 hours postingestion...
September 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27575830/review-of-perioperative-pain-management-of-opioid-dependent-patients
#13
Nalini Vadivelu, Sukanya Mitra, Alice M Kai, Gopal Kodumudi, Karina Gritsenko
Opioid dependence can occur due to prescription opioid use, recreational opioid use, or as a result of opioid use for the treatment of drug addiction. Pain control in these patients is truly a challenge. It is important to understand the patient's condition such as the phenomenon of drug dependence, drug addiction, and pseudoaddiction to provide effective analgesia. This may be accomplished using appropriate multimodal therapies and by treatment of coexisting diseases such as anxiety. The goal is to provide effective analgesia, prevent cognitive and emotional problems, and produce a positive postoperative rehabilitation process...
July 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27575829/caveat-emptor-erroneous-safety-information-about-opioids-in-online-drug-information-compendia
#14
Sonia R Talwar, Amarita S Randhawa, Erica H Dankiewicz, Nancy T Crudele, J David Haddox
BACKGROUND: Healthcare professionals and consumers refer to online drug-information compendia (eg, Epocrates and WebMD) to learn about prescription medications, including opioid analgesics. With the significant risks associated with opioids, including abuse, misuse, and addiction, any of which can result in life-threatening overdose, it is important for those seeking information from online compendia to have access to current, accurate, and complete drug information to help support clinical treatment decisions...
July 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27575828/novel-peer-review-method-for-improving-controlled-substance-prescribing-in-primary-care
#15
Brian Penti, Jane M Liebschutz, Brian Kopcza, Ziming Xuan, Christine Odell, Robert Saper
OBJECTIVE: Determine if peer feedback through a chart review tool (CRT) can impact opioid prescribing for patients with chronic noncancer pain in an outpatient family medicine clinic at an urban, safety-net teaching hospital and to assess providing practices. DESIGN: A quality improvement (QI) project, comparing preopioid and postopioid prescribing practices. SETTING: Outpatient family medicine clinic at urban, safety-net teaching hospital...
July 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27575827/prevalence-and-correlates-of-coprescribing-anxiolytic-medications-with-extensive-prescription-opioid-use-in-veterans-health-administration-patients-with-metastatic-cancer
#16
Declan T Barry, Mehmet Sofuoglu, Robert D Kerns, Ilse R Wiechers, Robert A Rosenheck
OBJECTIVE: To examine the prevalence and correlates of concomitant anxiolytic prescription fills in Veterans Health Administration (VHA) patients with metastatic cancer who have extensive prescription opioid use. DESIGN, SETTING, AND PARTICIPANTS: National VHA data for fiscal year 2012 were used to identify veterans diagnosed with metastatic cancer (ICD-9 codes 196-199) who also had extensive prescription opioid use (at least 10 opioid prescriptions during the year, comprising the highest 29 percent of opioid users)...
July 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27575826/clinical-analgesia-correlates-with-decline-in-temporal-summation-in-response-to-remifentanil-infusion-in-patients-with-chronic-neuropathic-radicular-pain
#17
Erica Suzan, Ayelet Midbari, Dorit Pud, Salim Hadad, Elon Eisenberg
BACKGROUND: Animal studies have shown that in addition to their antinociceptive effects, opioids have attenuated the electrophysiological "wind-up" phenomenon. Although effects of opioids on clinical pain and on temporal summation (TS), the human correlatives of this phenomenon, have been tested repeatedly, correlations between these two parameters have not been reported so far. OBJECTIVES: To search for possible correlations between the effects of remifentanil on clinical pain intensity and on the magnitude of TS in patients with chronic pain...
July 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27575825/what-s-in-a-number-recommending-practicality-in-the-data-2000-patient-limits
#18
Andrea G Barthwell, Jonathan M Young, Michael C Barnes, Shruti R Kulkarni
According to the Substance Abuse and Mental Health Services Administration, 2.4 million individuals have an opioid use disorder (OUD). Yet, nearly 80 percent of them-more than 1.9 million people-do not receive treatment. Medication-assisted treatment (MAT), specifically with buprenorphine, has proven to be effective in treating patients with OUDs while also reducing costs to the healthcare system, criminal justice system, and workforce. Despite its effectiveness, barriers to MAT continue to exist. Consequently, many individuals must wait months, if not years, to receive treatment...
July 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27575824/physician-conviction-for-prescription-related-deaths-how-will-this-affect-the-opioid-debate
#19
Humair Rana, Brian Braithwaite
No abstract text is available yet for this article.
July 2016: Journal of Opioid Management
https://www.readbyqxmd.com/read/27575823/reducing-the-community-prescribed-opioid-load-a-public-health-approach-to-the-opioid-epidemic
#20
Julia Lew, Kieran Moore
No abstract text is available yet for this article.
July 2016: Journal of Opioid Management
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