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Journal of Biomedical Materials Research. Part B, Applied Biomaterials

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https://www.readbyqxmd.com/read/29331090/enhanced-chondrogenesis-of-mesenchymal-stem-cells-over-silk-fibroin-chitosan-chondroitin-sulfate-three-dimensional-scaffold-in-dynamic-culture-condition
#1
Parinita Agrawal, Krishna Pramanik, Varshini Vishwanath, Amit Biswas, Akalabya Bissoyi, Pradeep Kumar Patra
Chondroitin sulfate (Ch) is one of the main structural components of cartilage tissue, therefore, its presence in tissue engineered scaffold is expected to enhance cartilage regeneration. Previously, silk fibroin/chitosan (SF/CS) blend was proven to be a potential biomaterial for tissue development. In this study, the effect of Ch on physicochemical and biological properties of SF/CS blend was investigated and scaffolds with 0.8 wt% Ch was found to be favorable. The scaffolds possess pore size of 37-212 µm, contact angle 46...
January 13, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29328519/surface-modification-using-the-biomimetic-method-in-alumina-zirconia-porous-ceramics-obtained-by-the-replica-method
#2
André D R Silva, Willian R Rigoli, Denise Osiro, Daphne C R Mello, Luana M R Vasconcellos, Anderson O Lobo, Eliria M J A Pallone
The modification of biomaterials approved by the Food and Drug Administration could be an alternative to reduce the period of use in humans. Porous bioceramics are widely used as support structures for bone formation and repair. This composite has essential characteristics for an implant, including good mechanical properties, high chemical stability, biocompatibility and adequate aesthetic appearance. Here, three-dimensional porous scaffolds of Al2 O3 containing 5% by volume of ZrO2 were produced by the replica method...
January 12, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29322633/preclinical-evaluation-of-melanocyte-transplantation-by-chitosan-based-melanocyte-spheroid-patch-to-skin-prepared-by-controlled-sunburn-blistering
#3
Sabrina Mai-Yi Fan, Po-Hua Chen, Yu-Ting Tseng, Jin-Bon Hong, Wannhsin Chen, Tsen-Fang Tsai, Sung-Jan Lin
Transplantation of autologous cultured melanocytes as cell suspension has been used for the treatment of vitiligo. The recipient site is often prepared by laser-mediated dermabrasion. Such procedures encounter disadvantages including prolonged transplantation duration, unsecured cell adherence to lesional skin and potential scarring. To improve this, here we propose a method by preparing recipient sites before transplantation by psoralen and ultraviolet A (PUVA)-induced sunburn followed by transplanting cells with a chitosan-based melanocyte spheroid patch...
January 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29322629/material-dependent-fretting-corrosion-in-spinal-fusion-devices-evaluation-of-onset-and-long-term-response
#4
Vaneet Singh, Jacob P Shorez, Sachin A Mali, Nadim J Hallab, Jeremy L Gilbert
Posterior spinal fusion implants include number of interconnecting components, which are subjected to micromotion under physiological loading conditions inducing a potential for fretting corrosion. There is very little known about the fretting corrosion in these devices in terms of the minimum angular displacement (threshold) necessary to induce fretting corrosion or the amount of fretting corrosion that can arise during the life of the implant. Therefore, the first goal was to evaluate the threshold fretting corrosion in three anatomical orientations and second the long-term fretting corrosion for the three different material types of spinal implants under physiological loading conditions...
January 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29316208/effect-of-bone-sialoprotein-coated-three-dimensional-printed-calcium-phosphate-scaffolds-on-primary-human-osteoblasts
#5
Anja Klein, Andreas Baranowski, Ulrike Ritz, Hermann Götz, Sascha Heinemann, Stefan Mattyasovszky, Pol M Rommens, Alexander Hofmann
The combination of the two techniques of rapid prototyping 3D-plotting and bioactive surface functionalization is presented, with emphasis on the in vitro effect of Bone Sialoprotein (BSP) on primary human osteoblasts (hOBs). Our primary objective was to demonstrate the BSP influence on the expression of distinctive osteoblast markers in hOBs. Secondary objectives included examinations of the scaffolds' surface and the stability of BSP-coating as well as investigations of cell viability and proliferation. 3D-plotted calcium phosphate cement (CPC) scaffolds were coated with BSP via physisorption...
January 9, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29314748/cyclotriphosphate-associated-to-fluoride-increases-hydroxyapatite-resistance-to-acid-attack
#6
Jackeline G Amaral, Juliano P Pessan, José Antonio S Souza, João Carlos S Moraes, Alberto Carlos B Delbem
This study evaluated the effect of sodium trimetaphosphate (TMP) associated or not with fluoride (F) on the structure and dissolution of carbonated hydroxyapatite (CHA). Synthetic CHA powder (1.0 g) was suspended in solutions containing TMP at 0-10%, associated with 0, 1100, 4500, or 9000 ppm F, and the precipitates were submitted to a pH cycle (n = 6/group). Samples were analyzed by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction. F, calcium (Ca) and phosphorous (P) concentrations were determined in CHA, while P and F were analyzed in the supernatants...
January 4, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29314671/different-compact-hybrid-langmuir-blodgett-film-coatings-modify-biomineralization-and-the-ability-of-osteoblasts-to-grow
#7
Amanda N de Faria, Marcos A E Cruz, Gília C M Ruiz, Daniela C Zancanela, Pietro Ciancaglini, Ana P Ramos
Calcium phosphates (CaPs) are biomaterials widely used in tissue regeneration with outstanding biological performance. Although the tremendous improvements achieved in CaP's materials research over the years, their interaction with physiological environments still need to be fully understood. The aim of this study is to explore a biomimetic Langmuir-Blodgett (LB) membrane to template the growth of hydroxyapatite (HAp) coatings on Ti surfaces and the ability of these coatings in inducing biomineralization by osteoblasts cultured in vitro...
January 4, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29282858/release-of-vancomycin-and-tobramycin-from-polymethylmethacrylate-cements-impregnated-with-calcium-polyphosphate-hydrogel
#8
Zubin Zhou, Joe Seta, David C Markel, Wei Song, Sally M Yurgelevic, Xiao Wei Yu, Weiping Ren
The influence of calcium polyphosphate (CPP) gel incorporation on the release of vancomycin and tobramycin from polymethyl methacrylate (PMMA) cement (Simplex P, SP) has been studied. Adding 10% CPP gel to SP led to a much lower burst release of vancomycin and considerably extended release of both vancomycin and tobramycin up to 24 weeks. Antibiotics released from this new material retain their bactericidal activity for up to 15 weeks. The improvement in the antibiotic release is mainly due to the molecular interactions of antibiotics with embedded CPP polyphosphate chains as confirmed by Raman spectroscopy analysis...
December 28, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29274252/development-of-hafnium-metal-and-titanium-hafnium-alloys-having-apatite-forming-ability-by-chemical-surface-modification
#9
Toshiki Miyazaki, Masaya Sueoka, Yuki Shirosaki, Nobuya Shinozaki, Takanobu Shiraishi
Hafnium (Hf) has attracted considerable attention as a component of biomedical titanium (Ti) alloys with low Young's moduli and/or shape-memory functionalities, because its cytotoxicity is as low as that of Ti. The drawback of metals is that their bone-bonding ability is generally low. It is known that apatite formation in the body is a prerequisite for bone-bonding. Although several chemical treatments have been proposed for preparing Ti for bone-bonding, there have been no similar investigations for Hf. In the present study, NaOH- and heat-treatments were applied to pure Hf and Ti-Hf alloys and their bone-bonding ability was assessed in vitro with the use of simulated body fluid (SBF)...
December 23, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29266734/nitric-oxide-releasing-vascular-catheters-for-eradicating-bacterial-infection
#10
Jitendra Pant, Marcus J Goudie, Sarah M Chaji, Benjamin W Johnson, Hitesh Handa
The interaction of blood proteins with an implant surface is not only a fundamental phenomenon but is also key to several important medical complications. Plasma proteins binding on the surface of intravascular catheters can promote bacterial adhesion leading to the risk of local and systemic complications such as catheter-related blood infections (CRBIs). The incidences of CRBIs in the United States amount to more than 250,000 cases/year with an attributable mortality of up to 35% and an annual healthcare expenditure of $2...
December 20, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29266701/hydoxyapatite-beta-tricalcium-phosphate-biphasic-ceramics-as-regenerative-material-for-the-repair-of-complex-bone-defects
#11
REVIEW
Gethin Rh Owen, Michel Dard, Hannu Larjava
Bone is a composite material composed of collagen and calcium phosphate (CaP) mineral. The collagen gives bone its flexibility while the inorganic material gives bone its resilience. The CaP in bone is similar in composition and structure to the mineral hydroxyapatite (HA) and is bioactive, osteoinductive and osteoconductive. Therefore synthetic versions of bone apatite (BA) have been developed to address the demand for autologous bone graft substitutes. Synthetic HA (s-HA) are stiff and strong, but brittle...
December 20, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29266687/reducing-fretting-initiated-crevice-corrosion-in-hip-simulator-tests-using-a-zirconia-toughened-alumina-femoral-head
#12
Masayuki Kyomoto, Yuichi Shoyama, Kenichi Saiga, Toru Moro, Kazuhiko Ishihara
Taper fretting corrosion is considered a potentially limiting factor for total hip arthroplasty longevity. Recently, attention has been focused on new materials for ceramic femoral heads, for example, zirconia-toughened alumina (ZTA), since they have an alternative bearing surface that can improve the wear resistance. Moreover, ceramics have high chemical stability and corrosion resistance. In this study, we evaluated the effects of ZTA and Co-Cr-Mo alloy femoral heads on their taper fretting and/or corrosion characteristics under a controlled hip simulator test...
December 20, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29247599/sterilization-of-hydrogels-for-biomedical-applications-a-review
#13
REVIEW
Raquel Galante, Terezinha J A Pinto, Rogério Colaço, Ana Paula Serro
Despite the beneficial properties and outstanding potential of hydrogels for biomedical applications, several unmet challenges must be overcome, especially regarding to their known sensitivity to conventional sterilization methods. It is crucial for any biomaterial to withstand an efficient sterilization to obtain approval from regulatory organizations and to safely proceed to clinical trials. Sterility assurance minimizes the incidence of medical device-related infections, which still constitute a major concern in health care...
December 16, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29226584/wool-derived-keratin-hydrogel-enhances-implant-osseointegration-in-cancellous-bone
#14
Warwick J Duncan, Philippa F C Greer, Min-Ho Lee, Carolina Loch, Jennifer H A Gay
AIM: This study investigated whether a keratin hydrogel derived from wool enhances ossointegration of dental implants, using a cancellous bone model in sheep. METHOD: Ten female sheep received one dental implant per hind leg in the distal femoral condyles. Test implants were coated with 1 mL of keratin hydrogel containing sulphonated keratin and hydroxyapatite; control implants remained uncoated; implants were not functionally loaded axially. Biomechanical stability was tested with resonance frequency analysis (RFA) at placement and euthanasia...
December 11, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29226582/proof-of-concept-testing-of-a-positive-reference-material-for-in-vivo-and-in-vitro-skin-irritation-testing
#15
Yusuke Nomura, Michelle Lee, Chie Fukui, Kayo Watanabe, Daniel Olsen, Audrey Turley, Yuki Morishita, Tsuyoshi Kawakami, Toshiyasu Yuba, Hideo Fujimaki, Kaoru Inoue, Midori Yoshida, Kumiko Ogawa, Yuji Haishima
In vivo and in vitro irritation testing is important for evaluating the biological safety of medical devices. Here, the performance of positive reference materials for skin irritation testing was evaluated. Four reference standards, referred to as Y-series materials, were analyzed: a polyvinyl chloride (PVC) sheet spiked with 0 (Y-1), 1.0 (Y-2), 1.5 (Y-3), or 10 (Y-4) parts of Genapol X-080 per 100 parts of PVC by weight. Y-1, Y-2, and Y-3 did not induce skin irritation responses in an in vitro reconstructed human epidermis (RhE) tissue model, as measured by tissue viability or interleukin-1α release, or in an in vivo intracutaneous response test using rabbits...
December 11, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29226556/solvent-or-thermal-extraction-of-ethylene-oxide-from-polymeric-materials-medical-device-considerations
#16
Anne D Lucas, Christopher Forrey, David M Saylor, Katherine Vorvolakos
Ethylene oxide (EO) gas is commonly used to sterilize medical devices. Bioavailable residual EO, however, presents a significant toxicity risk to patients. Residual EO is assessed using international standards describing extraction conditions for different medical device applications. We examine a series of polymers and explore different extraction conditions to determine residual EO. Materials were sterilized with EO and exhaustively extracted in water, in one of three organic solvents, or in air using thermal desorption...
December 11, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29226553/design-and-properties-of-a-novel-radiopaque-injectable-apatitic-calcium-phosphate-cement-suitable-for-image-guided-implantation
#17
Myriam Le Ferrec, Charlotte Mellier, Florian Boukhechba, Thomas Le Corroller, Daphné Guenoun, Franck Fayon, Valérie Montouillout, Christelle Despas, Alain Walcarius, Dominique Massiot, François-Xavier Lefèvre, Caroline Robic, Jean-Claude Scimeca, Jean-Michel Bouler, Bruno Bujoli
An injectable purely apatitic calcium phosphate cement (CPC) was successfully combined to a water-soluble radiopaque agent (i.e., Xenetix® ), to result in an optimized composition that was found to be as satisfactory as poly(methyl methacrylate) (PMMA) formulations used for vertebroplasty, in terms of radiopacity, texture and injectability. For that purpose, the Xenetix dosage in the cement paste was optimized by injection of the radiopaque CPC in human cadaveric vertebrae under classical PMMA vertebroplasty conditions, performed by interventional radiologists familiar with this surgical procedure...
December 11, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29219244/-click-on-plga-peg-and-hyaluronic-acid-gaining-access-to-anti-leishmanial-pentamidine-bioconjugates
#18
Angela Scala, Anna Piperno, Nicola Micale, Placido G Mineo, Antonio Abbadessa, Roberta Risoluti, Germano Castelli, Federica Bruno, Fabrizio Vitale, Antonio Cascio, Giovanni Grassi
Pentamidine (Pent), an antiparasitic drug used for the treatment of visceral leishmaniasis, has been modified with terminal azide groups and conjugated to two different polymer backbones (PLGA-PEG [PP] copolymer and hyaluronic acid [HA]) armed with alkyne end-groups. The conjugation has been performed by Copper Catalyzed Azido Alkyne Cycloaddition (CuAAC) using CuSO4 /sodium ascorbate as metal source. The novel PP-Pent and HA-Pent bioconjugates are proposed, respectively, as non-targeted and targeted drug delivery systems against Leishmania infections...
December 8, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29206331/bacterial-nanocellulose-ikvav-hydrogel-matrix-modulates-melanoma-tumor-cell-adhesion-and-proliferation-and-induces-vasculogenic-mimicry-in-vitro
#19
Emily M Dos Reis, Fernanda V Berti, Guilherme Colla, Luismar M Porto
Vasculogenic mimicry process has generated great interest over the past decade. So far, however, there have been only a few matrices available that allow us to study that process in vitro. Here, we have developed an innovative hydrogel platform with defined composition that mimics the structural architecture and biological functions of the extracellular matrix for vasculogenic mimicry of human melanoma cells (SK-MEL-28). We chemically immobilized IKVAV peptide on bacterial nanocellulose (BNC) fibers. BNC-IKVAV hydrogel was found to improve the adhesion and proliferation of SK-MEL-28 cells on the top and bottom surfaces...
December 5, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29206329/cardiac-tissue-regeneration-a-preliminary-study-on-carbon-based-nanotubes-gelatin-scaffold
#20
Manuela Cabiati, Federico Vozzi, Federica Gemma, Francesca Montemurro, Carmelo De Maria, Giovanni Vozzi, Claudio Domenici, Silvia Del Ry
The aim of this study was set-up and test of gelatin and carbon nanotubes scaffolds. Gelatin-based (5%) genipin cross-linked (0.2%) scaffolds embedding single-walled carbon nanotubes (SWCNTs, 0.3, 0.5, 0.7, 0.9, and 1.3% w/w) were prepared and mechanically/electrically characterized. For biological evaluation, H9c2 cell line was cultured for 10 days. Cytotoxicity, cell growth and differentiation, immunohistochemistry, and real-time PCR analysis were performed. Myoblast and cardiac differentiation were obtained by serum reduction to 1% (C1% ) and stimulation with 50 nM all trans-retinoic acid (CRA ), respectively...
December 5, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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