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Journal of Biomedical Materials Research. Part B, Applied Biomaterials

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https://www.readbyqxmd.com/read/28514061/mapping-intermediate-degradation-products-of-poly-lactic-co-glycolic-acid-in-vitro
#1
Jian Li, Peter Nemes, Ji Guo
There is widespread interest in using absorbable polymers, such as poly(lactic-co-glycolic acid) (PLGA), as components in the design and manufacture of new-generation drug eluting stents (DES). PLGA undergoes hydrolysis to progressively degrade through intermediate chemical entities to simple organic acids that are ultimately absorbed by the human body. Understanding the composition and structure of these intermediate degradation products is critical not only to elucidate polymer degradation pathways accurately, but also to assess the safety and performance of absorbable cardiovascular implants...
May 17, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28508595/silver-nanoparticle-deposited-implants-to-treat-osteomyelitis
#2
Samit Kumar Nandi, Anish Shivaram, Susmita Bose, Amit Bandyopadhyay
In this study, electrolytically deposited strongly adherent silver nanoparticles on stainless-steel (SS) implants were used for in situ osteomyelitis treatment. Samples were heat treated to enhance adhesion of silver on 316 L SS. Ex vivo studies were performed to measure silver-release profiles from the 316 L SS screws inserted in equine cadaver bones. No change in the release profiles of silver ions were observed in vitro between the implanted screws and the control. In vivo studies were performed using osteomyelitic rabbit model with 3 mm diameter silver-deposited 316 L SS pins at two different doses of silver: high and low...
May 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28508428/characterization-and-quantitation-of-pvp-content-in-a-silicone-hydrogel-contact-lens-produced-by-dual-phase-polymerization-processing
#3
Andrew J Hoteling, William F Nichols, Patricia S Harmon, Shawn M Conlon, Ivan M Nuñez, Joseph Hoff, Orlando M Cabarcos, Robert B Steffen, Daniel J Hook
Polyvinylpyrrolidone (PVP) has been incorporated over the years into numerous hydrogel contact lenses as both a primary matrix component and an internal wetting agent to increase lens wettability. In this study, complementary analytical techniques were used to characterize the PVP wetting agent component of senofilcon A and samfilcon A contact lenses, both in terms of chemical composition and amount present. Photo-differential scanning calorimetry (photo-DSC), gas chromatography with a flame ionization detector (GC-FID), and high-resolution/accurate mass (HR/AM) liquid chromatography-mass spectrometry (LC-MS) techniques confirmed dual phase reaction and curing of the samfilcon A silicone hydrogel material...
May 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28503902/electrochemical-and-biocompatibility-examinations-of-high-pressure-torsion-processed-titanium-and-ti-13nb-13zr-alloy
#4
Ivana Dimić, Ivana Cvijović-Alagić, Anton Hohenwarter, Reinhard Pippan, Vesna Kojić, Jelena Bajat, Marko Rakin
The purpose of this study was to estimate the electrochemical behavior and biocompatibility of ultrafine-grained (UFG) commercially pure titanium (CPTi) and Ti-13Nb-13Zr (TNZ) alloy obtained by high-pressure torsion process. Electrochemical behavior of materials in artificial saliva at 37°C was evaluated by potentiodynamic polarization tests and electrochemical impedance spectroscopy (EIS), and the obtained results indicated that UFG TNZ alloy showed corrosion current density (jcorr  = 53 ± 5 nA cm(-2) ) which was 2 times lower compared to coarse-grained (CG) TNZ alloy (jcorr  = 110 ± 12 nA cm(-2) ) and higher corrosion resistance, while UFG CPTi and CPTi showed approximately the same corrosion rate (mean jcorr ∼ 38-40 nA cm(-2) )...
May 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28503896/antibacterial-efficacy-of-poly-vinyl-alcohol-composite-nanofibers-embedded-with-silver-anchored-silica-nanoparticles
#5
Abdul Wahab Jatoi, Yun Kee Jo, Hoik Lee, Seong-Geun Oh, Dong Soo Hwang, Zeeshan Khatri, Hyung Joon Cha, Ick Soo Kim
Silver has been widely used as an effective antibacterial agent especially for treating burns and wounds. However, release of silver from materials often arouse side effects due to toxicity of silver towards mammalian cells. Argyria and argyrosis are well known problems of acute toxicity of silver towards human body. Immobilization of silver is an effective approach to reduce silver release. Herein, we present poly(vinyl alcohol) (PVA) composite nanofibers embedded with silver-anchored silica nanoparticles (SSNs) as a novel antibacterial material...
May 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28503805/development-of-a-siyalon-glaze-for-improved-osteoconductivity-of-implantable-medical-devices
#6
Ryan M Bock, Elia Marin, Alfredo Rondinella, Francesco Boschetto, Tetsuya Adachi, Bryan J McEntire, B Sonny Bal, Giuseppe Pezzotti
The application of bioactive coatings onto orthopaedic appliances is commonly performed to compensate for the otherwise bioinert nature of medical devices and to improve their osseointegration. Calcium phosphates, hydroxyapatite (HAp), and bioglasses are commercially available for this purpose. Until recently, few other inorganic compounds have been identified with similar biofunctionality. However, silicon nitride (Si3 N4 ) has emerged as a new orthopaedic material whose unique surface chemistry also enhances osteoconductivity...
May 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28503802/electrospun-polyethersolfone-nanofibrous-membrane-as-novel-platform-for-protein-immobilization-in-microfluidic-systems
#7
Matin Mahmoudifard, Manouchehr Vossoughi, Sara Soudi, Masoud Soleimani
In the present study, the feasibility of electrospun polyethersolfone (PES) nanofibrous membrane as the solid substrate for microfluidic based immunoassays to enhance the density of immobilized antibody on the surface of membrane was assessed. Conversely, the efficacy of antibody immobilization was compared by two different strategies as 1-Ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC)/N-Hydroxysuccinimide (NHS) coupling chemistry and hydrophobic interaction. Compared to conventional immunoassays carried out in plates or gels, microfluidic based immunoassays grant a lot of advantages such as a consumption of little samples and reagents, shorter analysis time, and higher efficiency...
May 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28500731/alternative-plasticizer-4-cyclohexene-1-2-dicarboxylic-acid-dinonyl-ester-for-blood-containers-with-protective-effects-on-red-blood-cells-and-improved-cold-resistance
#8
Yuki Morishita, Yusuke Nomura, Chie Fukui, Ayano Fujisawa, Kayo Watanabe, Hideo Fujimaki, Hidefumi Kumada, Kaoru Inoue, Tomomi Morikawa, Miwa Takahashi, Tsuyoshi Kawakami, Hideyuki Sakoda, Tomokazu Mukai, Toshiyasu Yuba, Ken-Ichi Inamura, Akito Tanoue, Ken-Ichi Miyazaki, Ung-Il Chung, Kumiko Ogawa, Midori Yoshida, Yuji Haishima
Di (2-ethylhexyl) phthalate (DEHP), a typical plasticizer used for polyvinyl chloride (PVC), is eluted from PVC-made blood containers and protects against red blood cell (RBC) hemolysis. However, concerns have arisen regarding the reproductive and developmental risks of DEHP in humans, and the use of alternative plasticizers for medical devices has been recommended worldwide. In this study, we propose that the use of a novel plasticizer, 4-cyclohexene-1,2-dicarboxylic acid dinonyl ester (DL9TH), could help produce more useful and safe blood containers...
May 13, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28485068/wear-resistance-of-poly-2-methacryloyloxyethyl-phosphorylcholine-grafted-carbon-fiber-reinforced-poly-ether-ether-ketone-liners-against-metal-and-ceramic-femoral-heads
#9
Shihori Yamane, Masayuki Kyomoto, Toru Moro, Masami Hashimoto, Yoshio Takatori, Sakae Tanaka, Kazuhiko Ishihara
Younger, active patients who undergo total hip arthroplasty (THA) have increasing needs for wider range of motion and improved stability of the joint. Therefore, bearing materials having not only higher wear resistance but also mechanical strength are required. Carbon fiber-reinforced poly(ether ether ketone) (CFR-PEEK) is known as a super engineering plastic that has great mechanical strength. In this study, we focused on poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-grafted CFR-PEEK and investigated the effects of PMPC grafting and the femoral heads materials on the wear properties of CFR-PEEK liners...
May 9, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28480642/effect-of-hap-and-%C3%AE-tcp-incorporation-on-the-tribological-response-of-ti6al4v-biocomposites-for-implant-parts
#10
T A Dantas, M M Costa, G Miranda, F S Silva, C S Abreu, J R Gomes
Titanium and its alloys have been widely used in many engineering areas due to their properties. Despite having a high implant-tissue osseointegration time, Ti6Al4V has been extensively used in prosthesis and articular implants. To promote a faster bone ingrowth and consequently reduce the implant fixation time, the addition of a bioactive phase to form a biocomposite seems to be an excellent solution. Because of their bioactivity and similarity in composition with the human bone, HAp and β-TCP are two of the most widely used calcium phosphates in biomedical applications...
May 8, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28480611/corrosion-behavior-of-surface-modifications-on-titanium-dental-implant-in-situ-bacteria-monitoring-by-electrochemical-techniques
#11
Ivan Díaz, Miguel Ángel Pacha-Olivenza, Ricardo Tejero, Eduardo Anitua, Maria Luisa González-Martín, Maria Lorenza Escudero, Maria Cristina García-Alonso
The effects of surface modifications and bacteria on the corrosion behavior of titanium have been studied. Five surface modifications were analyzed: two acid etchings (op V, op N), acid etching + anodic oxidation (op NT), sandblasting + acid etching (SLA), and machined surfaces (mach). The corrosion behavior of the surface modifications was evaluated by following the standard ANSI/AAMI/ISO 10993-15:2000. Cyclic potentiodynamic and potentiostatic anodic polarization tests and ion release by ICP-OES after immersion for 7 days in 0...
May 8, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28480604/initial-experiences-with-a-new-design-for-a-preattached-intravenous-port-device
#12
Ching-Yang Wu, Jui-Ying Fu, Ching-Feng Wu, Chia-Hui Cheng, Yen-Ting Liu, Po-Jen Ko, Yun-Hen Liu, Yen Chu
All available conventional ports share a common design, including catheter, locking nut, and port body, and all share two sites of structural weakness. One site is the junction between the locking nut and the proximal end of the catheter. The other site is the catheter fixation site between the locking nut and the protruding stud of the connecting tube. To overcome these shortcomings, we designed a new type of intravenous port which combines the connecting tube into one piece. The aims of this study were to test the mechanical characteristics of the new design and assess its safety in animal study...
May 8, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28480531/characterization-of-wear-debris-from-metal-on-metal-hip-implants-during-normal-wear-versus-edge-loading-conditions
#13
Michael Kovochich, Ernest S Fung, Ellen Donovan, Kenneth M Unice, Dennis J Paustenbach, Brent L Finley
Advantages of second-generation metal-on-metal (MoM) hip implants include low volumetric wear rates and the release of nanosized wear particles that are chemically inert and readily cleared from local tissue. In some patients, edge loading conditions occur, which result in higher volumetric wear. The objective of this study was to characterize the size, morphology, and chemistry of wear particles released from MoM hip implants during normal (40° angle) and edge-loading (65° angle with microseparation) conditions...
May 8, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28474403/modulation-of-surface-stiffness-and-cell-patterning-on-polymer-films-using-micropatterns
#14
Hiroshi Sunami, Yusuke Shimizu, Junko Denda, Ikuko Yokota, Tomokazu Yoshizawa, Yukiko Uechi, Hitoshi Nakasone, Yasuyuki Igarashi, Hidehiro Kishimoto, Masayuki Matsushita
Here, a new technology was developed to selectively produce areas of high and low surface Young's modulus on biomedical polymer films using micropatterns. First, an elastic polymer film was adhered to a striped micropattern to fabricate a micropattern-supported film. Next, the topography and Young's modulus of the film surface were mapped using atomic force microscopy. Contrasts between the concave and convex locations of the stripe pattern were obvious in the Young's modulus map, although the topographical map of the film surface appeared almost flat...
May 5, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28470936/supercritical-co2-assisted-process-for-the-production-of-high-purity-and-sterile-nano-hydroxyapatite-chitosan-hybrid-scaffolds
#15
G Ruphuy, M Souto-Lopes, D Paiva, P Costa, A E Rodrigues, F J Monteiro, C L Salgado, M H Fernandes, J C Lopes, M M Dias, M F Barreiro
Hybrid scaffolds composed of hydroxyapatite (HAp), in particular in its nanometric form (n-HAp), and chitosan (CS) are promising materials for non-load-bearing bone graft applications. The main constraints of their production concern the successful implementation of the final purification/neutralization and sterilization steps. Often, the used purification strategies can compromise scaffold structural features, and conventional sterilization techniques can result in material's thermal degradation and/or contamination with toxic residues...
May 4, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28456004/control-of-weft-yarn-or-density-improves-biocompatibility-of-pet-small-diameter-artificial-blood-vessels
#16
Xingyou Hu, Tao Hu, Guoping Guan, Shaoting Yu, Yufen Wu, Lu Wang
Polyethylene glycol terephthalate (PET) fabrics with woven structures have proved to be quite effective for use on large diameter artificial blood vessels. However, their use within small-diameter artificial blood vessels has been associated with poor long-term patency, a problem resulting from slow endothelialization on PET and an over hyperplasia of smooth muscle cells. Previous research from our laboratory has revealed that ICAM-1 can be used as a marker to investigate cell adhesion, an effect which was closely associated with cell behavior on the surface of polycaprolactone (PCL) films...
April 29, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28440891/evaluation-of-three-different-decontamination-techniques-on-biofilm-formation-and-on-physical-and-chemical-properties-of-resin-composites
#17
Carolina Bosso André, Andressa Dos Santos, Carmem Silvia Pfeifer, Marcelo Giannini, Emerson Marcelo Girotto, Jack Liborio Ferracane
OBJECTIVES: This study evaluated three different sterilization/disinfection techniques for resin composites on bacterial growth and surface modification after decontamination. METHODS: Two resin composites were sterilized/disinfected with three different techniques: UV light, 1% chloramine T, and 70% ethanol. Four different times were used for each technique to determine the shortest time that the solution or UV light was effective. The influence of sterilization/disinfection technique on bacterial growth was evaluated by analyzing the metabolic activity, using the AlamarBlue™ assay, bacterial viability, and SEM images from biofilms of Streptococcus mutans...
April 25, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28432818/characterization-of-decellularized-ovine-small-intestine-submucosal-layer-as-extracellular-matrix-based-scaffold-for-tissue-engineering
#18
Morteza Rashtbar, Jamshid Hadjati, Jafar Ai, Issa Jahanzad, Mahmoud Azami, Sadegh Shirian, Somayeh Ebrahimi-Barough, Esmaeil Sadroddiny
Extracellular matrix-based scaffolds derived from mammalian tissues have been used in tissue engineering applications. Among all the tissues, decellularized small intestine submucosal layer (SIS) has been recently investigated for its exceptional characteristics and biocompatibilities. These investigations have been mainly focused on the decellularized porcine SIS; however, there has not been any report on ovine SIS (OSIS) layer. In this study, OSIS was decellularized and its physical, chemical, and morphological properties were evaluated...
April 22, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28429412/bone-extracellular-matrix-hydrogel-enhances-osteogenic-differentiation-of-c2c12-myoblasts-and-mouse-primary-calvarial-cells
#19
Noura Alom, Heather Peto, Glen R Kirkham, Kevin M Shakesheff, Lisa J White
Hydrogel scaffolds derived from the extracellular matrix (ECM) of mammalian tissues have been successfully used to promote tissue repair in vitro and in vivo. The objective of this study was to evaluate the osteogenic potential of ECM hydrogels prepared from demineralized and decellularized bovine bone in the presence and absence of osteogenic medium. Culture of C2C12 and mouse primary calvarial cells (mPCs) on decellularized bone ECM (bECM) and demineralized bone matrix (DBM) gels resulted in increased expression of osteogenic gene markers, including a 3...
April 21, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28419733/interphotoreceptor-matrix-based-biomaterial-impact-on-human-retinal-progenitor-cell-attachment-and-differentiation
#20
Joydip Kundu, Andrew Michaelson, Petr Baranov, Marco Chiumiento, Tom Nigl, Michael J Young, Rebecca L Carrier
While cell transplantation therapies show great promise as treatments for retinal degeneration, the challenge of low cell survival upon transplantation motivates exploration of materials that may serve as cell delivery vehicles and promote survival and differentiation. In this study, we explored the native matrix that surrounds the outer segments of photoreceptors and promotes their homeostasis, interphotoreceptor matrix (IPM), as a substrate for human retinal progenitor cells (hRPCs). Bovine IPM was characterized to determine its structure and biochemical composition, and processed to develop substrates for cells...
April 18, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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