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Journal of Biomedical Materials Research. Part B, Applied Biomaterials

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https://www.readbyqxmd.com/read/29920923/effects-of-elastic-intramedullary-nails-composed-of-low-young-s-modulus-ti-nb-sn-alloy-on-healing-of-tibial-osteotomies-in-rabbits
#1
Atsushi Kogure, Yu Mori, Hidetatsu Tanaka, Masayuki Kamimura, Naoya Masahashi, Shuji Hanada, Eiji Itoi
Intramedullary nailing is widely performed for internal fixation of fractures. The applicable elasticity of materials composing intramedullary nails remains unclear. The present study aimed to evaluate the effects of the elastic property of β-type titanium alloy nails on fracture healing compared with conventional Ti-6Al-4V alloy nails using a rabbit tibial osteotomy model. Two types of intramedullary nails composed of β-type Ti-Nb-Sn alloy (Young's modulus: 37 GPa) or Ti-6Al-4V alloy (Young's modulus: 110 GPa) were used for osteotomy fixation in the tibiae of rabbits...
June 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29897162/in-vivo-biocompatibility-and-time-dependent-changes-in-mechanical-properties-of-woven-collagen-meshes-a-comparison-to-xenograft-and-synthetic-mid-urethral-sling-materials
#2
Katherine Chapin, Ahmad Khalifa, Thomas Mbimba, Phillip McClellan, James Anderson, Yuri Novitsky, Adonis Hijaz, Ozan Akkus
Meshes woven from highly aligned collagen threads crosslinked using either genipin or 1-ethyl-3-(3-dimethylaminopropyl) carboiimide and N-hydroxy succinimide (EDC/NHS) were implanted in a subcutaneous rat model to evaluate their biocompatibility (at 2 weeks, 2 months, and 5 months), mechanical properties (at baseline, 2 months, and 5 months) and ultimately their suitability for use as mid-urethral slings (MUS) for management of stress urinary incontinence. Porcine dermal (Xenmatrix) and monofilament polypropylene (Prolene) meshes were also implanted to provide comparison to clinically used materials...
June 13, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29802685/the-enhancement-of-osseointegration-using-a-graphene-oxide-chitosan-hydroxyapatite-composite-coating-on-titanium-fabricated-by-electrophoretic-deposition
#3
Lai Suo, Nan Jiang, Yan Wang, Puyu Wang, Junyu Chen, Xibo Pei, Jian Wang, Qianbing Wan
Titanium (Ti) has been commonly used as an implant material in dentistry and bone surgery for several decades. Meanwhile, surface modification of titanium can enhance the osseointegration of implants. In this study, a graphene oxide/chitosan/hydroxyapatite (GO/CS/HA) composite coating was fabricated by electrophoretic deposition on Ti substrates. Subsequently, the surface morphology, phase composition, wettability, and bonding strength of this composite coating were researched. Additionally, in vitro cytological examination was performed, including evaluations of cell adhesion, cell viability, cell differentiation, cell mineralization, and osteogenetic factor expression...
May 25, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29770578/effect-of-silicon-doped-calcium-phosphate-bone-grafting-materials-on-bone-regeneration-and-osteogenic-marker-expression-after-implantation-in-the-ovine-scapula
#4
Christine Knabe, Doaa Adel-Khattab, Wolf-Dietrich Hübner, Fabian Peters, Tom Knauf, Barbara Peleska, Dirk Barnewitz, Antje Genzel, Roderik Kusserow, Florian Sterzik, Michael Stiller, Christian Müller-Mai
Compared to the currently clinically available bone grafting materials for alveolar ridge augmentation, there is a great demand for bioactive bone substitutes with higher resorbability, which enhance osteogenesis at the same time. This has prompted the development of a silicon-doped rapidly resorbable calcium alkali orthophosphate (Si-CAOP) and silicon-doped β-tricalcium phosphate (Si-TCP). This study evaluated the effect of these two particulate graft materials as compared to the currently clinically used β-TCP on bone formation and osteogenic marker expression after 2 weeks, 1, 3, 6, 12, and 18 months of implantation in critical size defects in the sheep scapula...
May 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29770571/using-poly-l-lactic-acid-and-poly-%C3%A9-caprolactone-blends-to-fabricate-self-expanding-watertight-and-biodegradable-surgical-patches-for-potential-fetoscopic-myelomeningocele-repair
#5
Rigwed Tatu, Marc Oria, Sarah Pulliam, Lorenzo Signey, Marepalli B Rao, Jose L Peiro, Chia-Ying Lin
Our study focuses on the development and characterization of a self-expanding, watertight and biodegradable patch for fetoscopic myelomeningocele (MMC) prenatal repair. We fabricated poly(l-lactic acid) (PLA) and poly(ɛ-caprolactone) (PCL) blend films by solution casting. Formulation c with average glass transition temperature of 37.6 ± 1.2°C was chosen for temporospatial recovery. Favorable results from surface studies reflected homogeneous dispersion of polymers in the blend. The cytotoxicity was studied in human foreskin fibroblasts...
May 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29732734/io4-stimulated-crosslinking-of-catechol-conjugated-hydroxyethyl-chitosan-as-a-tissue-adhesive
#6
Xiaoting Peng, Yanfei Peng, Baoqin Han, Wanshun Liu, Fuming Zhang, Robert J Linhardt
Catechol-functionalized polymers are of particular interest because of their strong water-resistant adhesive properties. Hydroxymethyl chitosan (HECTS) has been used as an implantable biomaterial having good water solubility, biodegradability and biocompatibility. Here, hydrocaffeic acid (HCA) grafted HECTS (HCA-g-HECTS) was prepared through carbodiimide coupling and the tethered catechol underwent periodate (IO4-)-stimulated mono and double cross-linking with genipin. The gelation time of these cross-linked HCA-g-HECTS hydrogels decreased with increasing molar ratio of cross-linker to grafted catechol group, increasing temperature, or the addition of genipin...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29732690/in-vitro-cell-response-and-in-vivo-primary-osteointegration-of-highly-porous-ta-nb-alloys-as-implant-materials
#7
Jue Liu, Xiongwen Zhou, Huifeng Wang, Hailin Yang, Jianming Ruan
By combining the biocompatibility of Ta and excellent performance of Nb, the β-type Ta-xNb (x = 5, 10, and 15 wt %) alloys with three-dimensional network structure was successfully fabricated. This work was designed to carry out the systematic study of in vitro/vivo biocompatibility of highly porous Ta-Nb alloys. In the present study, the in vitro biological response was characterized by cell attachment, cytotoxicity test, and gene expression. Cells were well distributed on porous alloy surface and both bulk/porous Ta-15Nb alloys showd a 0-1 RGR level...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29732684/peri-prosthetic-tissue-reaction-to-discontinuation-of-negative-pressure-wound-therapy-around-porous-titanium-percutaneous-devices
#8
Divya R L Pawar, Saranne J Mitchell, Sujee Jeyapalina, Jason E Hawkes, Scott R Florell, Kent N Bachus
Negative pressure wound therapy (NPWT) has been reported to limit epithelial downgrowth, one of the failure mechanisms of percutaneous devices. In a previous study, when NPWT was applied for 4 weeks (NPWT Group) to porous coated titanium percutaneous devices, downgrowth (5 ± 4%; mean ± one SD) was significantly reduced compared to untreated controls (Untreated Group) (16 ± 6%; p ≤ 0.01). However, it was unclear whether this beneficial effect was sustained when NPWT was discontinued. In order to test this, porous coated titanium percutaneous devices were implanted into 6 hairless guinea pigs...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29732681/incidental-finding-of-a-degrading-zirconia-dental-implant-29-months-after-implantation-histological-and-histomorphometrical-analysis
#9
Alireza Houshmand, Phil Donkiewicz, Ralf Smeets, Ole Jung, Mike Barbeck
With the emerging development and improvement of biomaterials, the application of ceramics in restorative medicine has experienced a renaissance. New production processes have reportedly helped to overcome unfavorable biomechanical characteristics of these materials, which lead to a wide application of zirconia as ground material for dental implants. Zirconia-based implants are biocompatible, demonstrate ability to osseointegrate and have a teeth-like color, rendering them to be an ideal replacement for titanium-based implant systems, which represent the current gold standard in implantology...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29732669/polydimethylsiloxane-nano-calcium-phosphate-composite-tracheal-stents-mechanical-and-physiological-properties
#10
Kétner Bendo Demétrio, Marta Justina Giotti Cioato, Alexandre Moreschi, Guilherme Augusto Oliveira, William Lorenzi, Francine Hehn de Oliveira, Amarílio Vieira de Macedo Neto, Paulo Roberto Stefani Sanches, Rogerio Gastal Xavier, Luís Alberto Loureiro Dos Santos
In this study, we report the production and characterization of tracheal stents composed of polydimethylsiloxane/nanostructured calcium phosphate composites obtained by reactive synthesis. Tracheal stents were produced by transfer molding, and in vivo tests were carried out. PDMS was combined with H3 PO4 and Ca(OH)2 via an in situ reaction to obtain nanoparticles of calcium phosphate dispersed within the polymeric matrix. The incorporation of bioactive inorganic substances, such as calcium phosphates, improved biological properties, and the in situ reaction allowed tight coupling of particles to the matrix...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29732661/wear-properties-of-poly-ether-ether-ketone-bearing-combinations-under-zero-and-cross-shear-kinematics-in-total-knee-arthroplasty
#11
Kathryn A Chamberlain, Kenneth S Rankin, Adam Briscoe, David Deehan, Philip J Hyde
Poly-ether-ether-ketone (PEEK), having shown favorable biocompatibility in spinal applications is being considered as an alternative biomaterial in orthopaedics, either as part of an all-polymer bearing couple, or a replacement for the metallic component in hard-on-soft bearings. Throughout the literature ultra-high molecular weight polyethylene exhibits a range of wear behavior dependent upon the amount of cross shear (CS) present in the bearing motion; in comparison, the behavior of PEEK bearing combinations subject to cross shear conditions is less understood...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29722123/a-tricalcium-phosphate-polyether-ether-ketone-anchor-bionic-fixation-device-for-anterior-cruciate-ligament-reconstruction-safety-and-efficacy-in-a-beagle-model
#12
Genwen Mao, Zili Qin, Zheng Li, Xiang Li, Yusheng Qiu, Weiguo Bian
The goal of this study was to develop a bionic fixation device based on the use of a tricalcium phosphate/polyether ether ketone anchor and harvesting of the ulnar carpal flexor muscle tendon for application as a ligament graft in a beagle anterior cruciate ligament (ACL) reconstruction model, with the goal of accelerating the ligament graft-to-bone tunnel healing and providing a robust stability through exploration of this new kind of autologous ligament graft. The safety and efficacy of this fixation device were explored 3 and 6 months after surgery in a beagle ACL reconstruction model using biomechanical tests and comprehensive histological observation...
May 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29722122/a-comparison-of-the-bone-regeneration-and-soft-tissue-formation-capabilities-of-various-injectable-grafting-materials-in-a-rabbit-calvarial-defect-model
#13
Chih-Long Chen, Han-Wen Tien, Chia-Hui Chuang, Ying-Chieh Chen
Restoring adequate blood supply is essential to the success of bone repair and augmentation procedures in craniofacial surgery. Nevertheless, the manner by which the incorporation of collagen gels (which can potentially induce angiogenesis), particulated deproteinized bovine bone grafts, or a combination of both can accelerate or delay bone regeneration in a clinical setting remains controversial. The objective of this study was to evaluate radiographically and histologically the capacity and functionality of particulated bone grafts and collagen gels on bone ossification and soft tissue formation in a rabbit calvarial defect...
May 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29722119/development-of-mesoporous-bioactive-glass-nanoparticles-and-its-use-in-bone-tissue-engineering
#14
REVIEW
Chee Hoe Kong, Chris Steffi, Zhilong Shi, Wilson Wang
The incidence of bone disorders, from trauma, tissue degeneration due to ageing, pathological conditions to cancer, has been increasing. The pursuit for bone graft substitutes to assist in regenerating large bone defects is ever growing as a result of the shortage in conventional autografts and allografts, in addition to the associated risks of disease transmission. However, the use of alloplastic biomaterials is limited in clinical settings, as further investigations are required to address the properties of synthetic grafts to mimic the native bone tissue and deliver desirable biomolecules to facilitate bone regeneration...
May 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29717817/a-multilayer-scaffold-design-with-spatial-arrangement-of-cells-to-modulate-esophageal-tissue-growth
#15
Sherif Soliman, Julie Laurent, Lena Kalenjian, Kalia Burnette, Bert Hedberg, Saverio La Francesca
Esophageal diseases may require resectioning of the damaged portion. The current standard of care requires the replacement of the esophagus with the stomach or the intestine. Such procedures have high rates of mortality and morbidity; therefore, the use of alternative conduits is needed. A tissue engineering approach that allows for the regeneration of esophageal tissues would have significant clinical application. A cell-seeded synthetic scaffold could replace the resected part of the esophagus and elicit tissue regrowth...
May 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29717804/three-dimensional-printed-polycaprolactone-microcrystalline-cellulose-scaffolds
#16
Maria Elena Alemán-Domínguez, Elena Giusto, Zaida Ortega, Maryam Tamaddon, Antonio Nizardo Benítez, Chaozong Liu
Microcrystalline cellulose (MCC) is proposed in this study as an additive in polycaprolactone (PCL) matrices to obtain three-dimensional (3D) printed scaffolds with improved mechanical and biological properties. Improving the mechanical behavior and the biological performance of polycaprolactone-based scaffolds allows to increase the potential of these structures for bone tissue engineering. Different groups of samples were evaluated in order to analyze the effect of the additive in the properties of the PCL matrix...
May 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29697188/biodegradable-silk-catheters-for-the-delivery-of-therapeutics-across-anatomical-repair-sites
#17
Joseph E Brown, Lorenzo Tozzi, Benjamin Schilling, Arta Kelmendi-Doko, April B Truong, Maria J Rodriguez, Eun Seok Gil, Robert Sucsy, Jolene E Valentin, Brian J Philips, Kacey G Marra, J Peter Rubin, David L Kaplan
Biodegradable silk catheters for the delivery of therapeutics are designed with a focus on creating porous gradients that can direct the release of molecules away from the implantation site. Though suitable for a range of applications, these catheters are designed for drug delivery to transplanted adipose tissue in patients having undergone a fat grafting procedure. A common complication for fat grafts is the rapid reabsorption of large volume adipose transplants. In order to prolong volume retention, biodegradable catheters can be embedded into transplanted tissue to deliver nutrients, growth factors or therapeutics to improve adipocyte viability, proliferation, and ultimately extend volume retention...
April 26, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29687955/optimization-of-ca-2-content-in-alginate-hydrogel-injected-in-myocardium
#18
Eleonora Barka, Demetrios K Papayannis, Theofilos M Kolettis, Simeon Agathopoulos
The spontaneous uptake of Ca2+ -ions is a unique property of alginate hydrogels, which, along with their high biocompatibility, disintegration (approximately within 2 weeks), and morphological similarity to heart tissue, makes them attractive as scaffolding materials in therapies in infarct myocardium. To shed light on the aforementioned ability, thorough theoretical calculations were carried out with the density functional theory (DFT) method. The influence of Ca-content οn the molecular structure and the thermodynamic stability of the alginate hydrogel was determined; what is more, these results effectively interpreted the experimental findings, as well...
April 24, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28888071/the-effect-of-ventricular-assist-device-associated-biomaterials-on-human-blood-leukocytes
#19
Gemma Radley, Ina Laura Pieper, Catherine A Thornton
Ventricular assist devices (VADs) are an effective bridging or destination therapy for patients with advanced stage heart failure. These devices remain susceptible to adverse events including infection, bleeding, and thrombus; events linked to the foreign body response. Therefore, the biocompatibility of all biomaterials used is crucial to the success of medical devices. Biomaterials common in VADs-DLC: diamond-like carbon coated stainless steel; Sap: single-crystal sapphire; SiN: silicon nitride; Ti: titanium alloy; and ZTA: zirconia-toughened alumina-were tested for their biocompatibility through incubation with whole human blood for 2 h with mild agitation...
July 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28834247/regeneration-of-the-cementum-and-periodontal-ligament-using-local-bdnf-delivery-in-class-ii-furcation-defects
#20
Ryo Jimbo, Jessica Singer, Nick Tovar, Charles Marin, Rodrigo Neiva, Estevam A Bonfante, Malvin N Janal, Hugues Contamin, Paulo G Coelho
Periodontal furcation defects are usually addressed by the placement of a physical barrier which may limit the regenerative potential of periodontal wounds. This study morphometrically quantified the regenerative effect of brain-derived neurotrophic factor (BDNF) in furcation defects in a non-human primate model. Grade II furcation defects (with and without induced inflammation prior to surgery) were created on the first and second molars of eight non-human primates. Defects were treated with open flap debridement and subsequently filled with either: Group A; BDNF (500 µg mL-1 ) in high-molecular weight-hyaluronic acid (HMW-HA), Group B; BDNF (50 µg mL-1 ) in HMW-HA, Group C; HMW-HA acid only, Group D; unfilled defect, or Group E; BDNF (500 µg mL-1 ) in saline...
May 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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