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Journal of Biomedical Materials Research. Part B, Applied Biomaterials

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https://www.readbyqxmd.com/read/29770578/effect-of-silicon-doped-calcium-phosphate-bone-grafting-materials-on-bone-regeneration-and-osteogenic-marker-expression-after-implantation-in-the-ovine-scapula
#1
Christine Knabe, Doaa Adel-Khattab, Wolf-Dietrich Hübner, Fabian Peters, Tom Knauf, Barbara Peleska, Dirk Barnewitz, Antje Genzel, Roderik Kusserow, Florian Sterzik, Michael Stiller, Christian Müller-Mai
Compared to the currently clinically available bone grafting materials for alveolar ridge augmentation, there is a great demand for bioactive bone substitutes with higher resorbability, which enhance osteogenesis at the same time. This has prompted the development of a silicon-doped rapidly resorbable calcium alkali orthophosphate (Si-CAOP) and silicon-doped β-tricalcium phosphate (Si-TCP). This study evaluated the effect of these two particulate graft materials as compared to the currently clinically used β-TCP on bone formation and osteogenic marker expression after 2 weeks, 1, 3, 6, 12, and 18 months of implantation in critical size defects in the sheep scapula...
May 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29770571/using-poly-l-lactic-acid-and-poly-%C3%A9-caprolactone-blends-to-fabricate-self-expanding-watertight-and-biodegradable-surgical-patches-for-potential-fetoscopic-myelomeningocele-repair
#2
Rigwed Tatu, Marc Oria, Sarah Pulliam, Lorenzo Signey, Marepalli B Rao, Jose L Peiro, Chia-Ying Lin
Our study focuses on the development and characterization of a self-expanding, watertight and biodegradable patch for fetoscopic myelomeningocele (MMC) prenatal repair. We fabricated poly(l-lactic acid) (PLA) and poly(ɛ-caprolactone) (PCL) blend films by solution casting. Formulation c with average glass transition temperature of 37.6 ± 1.2°C was chosen for temporospatial recovery. Favorable results from surface studies reflected homogeneous dispersion of polymers in the blend. The cytotoxicity was studied in human foreskin fibroblasts...
May 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29732734/io4-stimulated-crosslinking-of-catechol-conjugated-hydroxyethyl-chitosan-as-a-tissue-adhesive
#3
Xiaoting Peng, Yanfei Peng, Baoqin Han, Wanshun Liu, Fuming Zhang, Robert J Linhardt
Catechol-functionalized polymers are of particular interest because of their strong water-resistant adhesive properties. Hydroxymethyl chitosan (HECTS) has been used as an implantable biomaterial having good water solubility, biodegradability and biocompatibility. Here, hydrocaffeic acid (HCA) grafted HECTS (HCA-g-HECTS) was prepared through carbodiimide coupling and the tethered catechol underwent periodate (IO4-)-stimulated mono and double cross-linking with genipin. The gelation time of these cross-linked HCA-g-HECTS hydrogels decreased with increasing molar ratio of cross-linker to grafted catechol group, increasing temperature, or the addition of genipin...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29732690/in-vitro-cell-response-and-in-vivo-primary-osteointegration-of-highly-porous-ta-nb-alloys-as-implant-materials
#4
Jue Liu, Xiongwen Zhou, Huifeng Wang, Hailin Yang, Jianming Ruan
By combining the biocompatibility of Ta and excellent performance of Nb, the β-type Ta-xNb (x = 5, 10, and 15 wt %) alloys with three-dimensional network structure was successfully fabricated. This work was designed to carry out the systematic study of in vitro/vivo biocompatibility of highly porous Ta-Nb alloys. In the present study, the in vitro biological response was characterized by cell attachment, cytotoxicity test, and gene expression. Cells were well distributed on porous alloy surface and both bulk/porous Ta-15Nb alloys showd a 0-1 RGR level...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29732684/peri-prosthetic-tissue-reaction-to-discontinuation-of-negative-pressure-wound-therapy-around-porous-titanium-percutaneous-devices
#5
Divya R L Pawar, Saranne J Mitchell, Sujee Jeyapalina, Jason E Hawkes, Scott R Florell, Kent N Bachus
Negative pressure wound therapy (NPWT) has been reported to limit epithelial downgrowth, one of the failure mechanisms of percutaneous devices. In a previous study, when NPWT was applied for 4 weeks (NPWT Group) to porous coated titanium percutaneous devices, downgrowth (5 ± 4%; mean ± one SD) was significantly reduced compared to untreated controls (Untreated Group) (16 ± 6%; p ≤ 0.01). However, it was unclear whether this beneficial effect was sustained when NPWT was discontinued. In order to test this, porous coated titanium percutaneous devices were implanted into 6 hairless guinea pigs...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29732681/incidental-finding-of-a-degrading-zirconia-dental-implant-29-months-after-implantation-histological-and-histomorphometrical-analysis
#6
Alireza Houshmand, Phil Donkiewicz, Ralf Smeets, Ole Jung, Mike Barbeck
With the emerging development and improvement of biomaterials, the application of ceramics in restorative medicine has experienced a renaissance. New production processes have reportedly helped to overcome unfavorable biomechanical characteristics of these materials, which lead to a wide application of zirconia as ground material for dental implants. Zirconia-based implants are biocompatible, demonstrate ability to osseointegrate and have a teeth-like color, rendering them to be an ideal replacement for titanium-based implant systems, which represent the current gold standard in implantology...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29732669/polydimethylsiloxane-nano-calcium-phosphate-composite-tracheal-stents-mechanical-and-physiological-properties
#7
Kétner Bendo Demétrio, Marta Justina Giotti Cioato, Alexandre Moreschi, Guilherme Augusto Oliveira, William Lorenzi, Francine Hehn de Oliveira, Amarílio Vieira de Macedo Neto, Paulo Roberto Stefani Sanches, Rogerio Gastal Xavier, Luís Alberto Loureiro Dos Santos
In this study, we report the production and characterization of tracheal stents composed of polydimethylsiloxane/nanostructured calcium phosphate composites obtained by reactive synthesis. Tracheal stents were produced by transfer molding, and in vivo tests were carried out. PDMS was combined with H3 PO4 and Ca(OH)2 via an in situ reaction to obtain nanoparticles of calcium phosphate dispersed within the polymeric matrix. The incorporation of bioactive inorganic substances, such as calcium phosphates, improved biological properties, and the in situ reaction allowed tight coupling of particles to the matrix...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29732661/wear-properties-of-poly-ether-ether-ketone-bearing-combinations-under-zero-and-cross-shear-kinematics-in-total-knee-arthroplasty
#8
Kathryn A Chamberlain, Kenneth S Rankin, Adam Briscoe, David Deehan, Philip J Hyde
Poly-ether-ether-ketone (PEEK), having shown favorable biocompatibility in spinal applications is being considered as an alternative biomaterial in orthopaedics, either as part of an all-polymer bearing couple, or a replacement for the metallic component in hard-on-soft bearings. Throughout the literature ultra-high molecular weight polyethylene exhibits a range of wear behavior dependent upon the amount of cross shear (CS) present in the bearing motion; in comparison, the behavior of PEEK bearing combinations subject to cross shear conditions is less understood...
May 7, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29722123/a-tricalcium-phosphate-polyether-ether-ketone-anchor-bionic-fixation-device-for-anterior-cruciate-ligament-reconstruction-safety-and-efficacy-in-a-beagle-model
#9
Genwen Mao, Zili Qin, Zheng Li, Xiang Li, Yusheng Qiu, Weiguo Bian
The goal of this study was to develop a bionic fixation device based on the use of a tricalcium phosphate/polyether ether ketone anchor and harvesting of the ulnar carpal flexor muscle tendon for application as a ligament graft in a beagle anterior cruciate ligament (ACL) reconstruction model, with the goal of accelerating the ligament graft-to-bone tunnel healing and providing a robust stability through exploration of this new kind of autologous ligament graft. The safety and efficacy of this fixation device were explored 3 and 6 months after surgery in a beagle ACL reconstruction model using biomechanical tests and comprehensive histological observation...
May 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29722122/a-comparison-of-the-bone-regeneration-and-soft-tissue-formation-capabilities-of-various-injectable-grafting-materials-in-a-rabbit-calvarial-defect-model
#10
Chih-Long Chen, Han-Wen Tien, Chia-Hui Chuang, Ying-Chieh Chen
Restoring adequate blood supply is essential to the success of bone repair and augmentation procedures in craniofacial surgery. Nevertheless, the manner by which the incorporation of collagen gels (which can potentially induce angiogenesis), particulated deproteinized bovine bone grafts, or a combination of both can accelerate or delay bone regeneration in a clinical setting remains controversial. The objective of this study was to evaluate radiographically and histologically the capacity and functionality of particulated bone grafts and collagen gels on bone ossification and soft tissue formation in a rabbit calvarial defect...
May 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29722119/development-of-mesoporous-bioactive-glass-nanoparticles-and-its-use-in-bone-tissue-engineering
#11
REVIEW
Chee Hoe Kong, Chris Steffi, Zhilong Shi, Wilson Wang
The incidence of bone disorders, from trauma, tissue degeneration due to ageing, pathological conditions to cancer, has been increasing. The pursuit for bone graft substitutes to assist in regenerating large bone defects is ever growing as a result of the shortage in conventional autografts and allografts, in addition to the associated risks of disease transmission. However, the use of alloplastic biomaterials is limited in clinical settings, as further investigations are required to address the properties of synthetic grafts to mimic the native bone tissue and deliver desirable biomolecules to facilitate bone regeneration...
May 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29717817/a-multilayer-scaffold-design-with-spatial-arrangement-of-cells-to-modulate-esophageal-tissue-growth
#12
Sherif Soliman, Julie Laurent, Lena Kalenjian, Kalia Burnette, Bert Hedberg, Saverio La Francesca
Esophageal diseases may require resectioning of the damaged portion. The current standard of care requires the replacement of the esophagus with the stomach or the intestine. Such procedures have high rates of mortality and morbidity; therefore, the use of alternative conduits is needed. A tissue engineering approach that allows for the regeneration of esophageal tissues would have significant clinical application. A cell-seeded synthetic scaffold could replace the resected part of the esophagus and elicit tissue regrowth...
May 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29717804/three-dimensional-printed-polycaprolactone-microcrystalline-cellulose-scaffolds
#13
Maria Elena Alemán-Domínguez, Elena Giusto, Zaida Ortega, Maryam Tamaddon, Antonio Nizardo Benítez, Chaozong Liu
Microcrystalline cellulose (MCC) is proposed in this study as an additive in polycaprolactone (PCL) matrices to obtain three-dimensional (3D) printed scaffolds with improved mechanical and biological properties. Improving the mechanical behavior and the biological performance of polycaprolactone-based scaffolds allows to increase the potential of these structures for bone tissue engineering. Different groups of samples were evaluated in order to analyze the effect of the additive in the properties of the PCL matrix...
May 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29697188/biodegradable-silk-catheters-for-the-delivery-of-therapeutics-across-anatomical-repair-sites
#14
Joseph E Brown, Lorenzo Tozzi, Benjamin Schilling, Arta Kelmendi-Doko, April B Truong, Maria J Rodriguez, Eun Seok Gil, Robert Sucsy, Jolene E Valentin, Brian J Philips, Kacey G Marra, J Peter Rubin, David L Kaplan
Biodegradable silk catheters for the delivery of therapeutics are designed with a focus on creating porous gradients that can direct the release of molecules away from the implantation site. Though suitable for a range of applications, these catheters are designed for drug delivery to transplanted adipose tissue in patients having undergone a fat grafting procedure. A common complication for fat grafts is the rapid reabsorption of large volume adipose transplants. In order to prolong volume retention, biodegradable catheters can be embedded into transplanted tissue to deliver nutrients, growth factors or therapeutics to improve adipocyte viability, proliferation, and ultimately extend volume retention...
April 26, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29687955/optimization-of-ca-2-content-in-alginate-hydrogel-injected-in-myocardium
#15
Eleonora Barka, Demetrios K Papayannis, Theofilos M Kolettis, Simeon Agathopoulos
The spontaneous uptake of Ca2+ -ions is a unique property of alginate hydrogels, which, along with their high biocompatibility, disintegration (approximately within 2 weeks), and morphological similarity to heart tissue, makes them attractive as scaffolding materials in therapies in infarct myocardium. To shed light on the aforementioned ability, thorough theoretical calculations were carried out with the density functional theory (DFT) method. The influence of Ca-content οn the molecular structure and the thermodynamic stability of the alginate hydrogel was determined; what is more, these results effectively interpreted the experimental findings, as well...
April 24, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29675998/biomaterial-granules-used-for-filling-bone-defects-constitute-3d-scaffolds-porosity-microarchitecture-and-molecular-composition-analyzed-by-microct-and-raman-microspectroscopy
#16
Baptiste Arbez, Jean-Daniel Kün-Darbois, Thierry Convert, Bernard Guillaume, Philippe Mercier, Laurent Hubert, Daniel Chappard
Biomaterials are used in the granular form to fill small bone defects. Granules can be prepared with a grinder from trabecular bone samples or provided as synthetic biomaterials by industry. Granules occupy the 3D-space and create a macroporosity allowing invasion of vascular and bone cells when the inter-granular pores are larger than 300 µm. We compared the 3D-porosity of granule stacks obtained or prepared with nine biomaterials Osteopure® , Lubboc® , Bio-Oss® , CopiOs® , TCP Dental® , TCP Dental HP® , KeraOs® , and TCH® in comparison with that of human trabecular bone...
April 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29675920/long-term-feasibility-and-biocompatibility-of-directly-microsurgically-implanted-intrafascicular-electrodes-in-free-roaming-rabbits
#17
Gehua Zhen, Huanwen Chen, Shin-Yi Tsai, Jian Zhang, Tongyi Chen, Xiaofeng Jia
Novel neural interfaces capable of reliably capturing electrical signals are crucial for the development of prostheses. Longitudinal intrafascicular electrodes (LIFEs) have been proposed as a promising technology, and their feasibility and biocompatibility need to be investigated for long-term implantation. In this study, custom-designed 95%Pt-5%Ir intrafascicular electrodes were implanted into the sciatic nerves of 14 rabbits using our novel direct microsurgical technique. The biocompatibility and their ability to record electrophysiological signals were serially investigated up to 9 months after implantation...
April 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29675859/fabrication-of-superparamagnetic-nanofibrous-poly-l-lactic-acid-%C3%AE-fe-2-o-3-microspheres-for-cell-carriers
#18
Moyuan Qu, Wenqian Xiao, Jiarong Tian, Song Wang, Hong Li, Xue Liu, Xiaoling Yang, Bo Li, Xiaoling Liao
Nanofibrous poly(l-lactic acid) (PLLA) microspheres are extensively studied to be used as cell carriers in the field of tissue engineering because the unique structure can promote cell proliferation and migration. But as injectable scaffold materials, PLLA microspheres easily run off to the soft tissue space because of the lack of cohesive force. It will affect the treatment efficiency and even cause additional inflammatory response. In order to overcome this disadvantage, superparamagnetic γ-Fe2 O3 nanoparticles assisted with oxidative polymerization of dopamine were used for surface modification of PLLA microspheres in this study...
April 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29663665/investigation-of-nano-sized-debris-released-from-cocrmo-secondary-interfaces-in-total-hip-replacements-digestion-of-the-flakes
#19
Alina M Crainic, Mauro Callisti, Martin R Palmer, Richard B Cook
The in vivo release of wear debris and corrosion products from the metallic interfaces of total hip replacements is associated with a wide spectrum of adverse body reactions and systemic manifestations. The origin of debris and the electrochemical conditions at the sites of material loss both play a role in determining the physicochemical characteristics of the particles, and thus influence their in vivo reactivity. Debris retrieved from revised CoCrMo tapers and cement-stem interfaces consists of heterogeneous flakes that comprise mechanically mixed metal particles, corrosion products and organic material...
April 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29663651/engineered-natural-and-synthetic-polymer-surfaces-induce-nuclear-deformation-in-osteosarcoma-cells
#20
Ezgi Antmen, Menekse Ermis, Utkan Demirci, Vasif Hasirci
Cell-substrate interactions involve constant probing of microenvironment by cells. One of the responses of cells to environmental cues is to change the conformation of their cytoplasm and nucleus. We hypothesized that surface chemistry and topography could be engineered to make these differences significant enough. When designing the substrates that would accentuate these differences, we prepared surfaces carrying cell adhesive biological cues arranged in specific patterns. Collagen type I and poly(lactic acid-co-glycolic acid) (PLGA) were used to represent substrates with biological cues and those without, and these materials were decorated with four square prism micropillars with different dimensions...
April 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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