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Journal of Biomedical Materials Research. Part B, Applied Biomaterials

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https://www.readbyqxmd.com/read/29149487/fabrication-of-chelate-setting-%C3%AE-tricalcium-phosphate-cement-using-sodium-citrate-and-sodium-alginate-as-mixing-solution-and-its-in-vivo-osteoconductivity
#1
Toshiisa Konishi, Poon Nian Lim, Michiyo Honda, Masaki Nagaya, Hiroshi Nagashima, Eng San Thian, Mamoru Aizawa
Moldable and injectable calcium-phosphate cements (CPCs) are material candidates for bone replacement applications. In the present study, we examined the effectiveness of sodium alginate and sodium citrate additives to the liquid phase of CPC, in improving its handling property as well as mechanical strength. The use of these additives enhanced the handling property significantly, in terms of consistency as compared to CPC without additives due to the liquefying effect caused by the adsorption of citrate ions on the cement particles...
November 17, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29140580/enhanced-biological-fixation-of-ligaments-to-bone-tissues-utilizing-chitin-fabrics
#2
Hisaya Nomata, Michiko Nakaishi, Kazuo Takakuda
In ligament reconstruction involving anterior cruciate ligament surgery, biological fixation between the transferred ligament and bone tissue is critical for achieving successful outcomes. Here, we administered chitin fabrics into the bone tunnels and evaluated their efficacy in promoting biological fixation. An animal model on the rat's patellar ligament was employed. First, bone tunnels were created in the lateral condyle of the femur. The ligament was then separated from the tibial tuberosity, and half was inserted into the tunnel and fixed with the use of end button...
November 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29130596/evaluation-of-a-bioengineered-construct-for-tissue-engineering-applications
#3
Perla Ayala, Erbin Dai, Michael Hawes, Liying Liu, Ovijit Chaudhuri, Carolyn A Haller, David J Mooney, Elliot L Chaikof
Effective biomaterial options for tissue repair and regeneration are limited. Current biologic meshes are derived from different tissue sources and are generally sold as decellularized tissues. This work evaluated two collagen based bioengineered constructs and a commercial product in a model of abdominal full thickness defect repair. To prepare the bioengineered construct, collagen type 1 from porcine skin was isolated using an acid solubilization method. After purification, the collagen was formed into collagen sheets that were physically bonded to form a mechanically robust construct that was subsequently laser micropatterned with pores as a means to promote tissue integration (collagen only construct)...
November 11, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29106034/evaluation-of-central-venous-catheters-coated-with-a-noble-metal-alloy-a-randomized-clinical-pilot-study-of-coating-durability-performance-and-tolerability
#4
Gunilla Björling, Dorota Johansson, Linda Bergström, Anton Strekalovsky, Javier Sanchez, Claes Frostell, Sigridur Kalman
The use of Central Venous Catheters (CVCs) commonly results in complications. Coatings with silver or metal alloys can reduce the risk associated with the use of CVC. We have evaluated the durability of a noble metal coated CVC (the Bactiguard Infectious Protection, BIP CVC) and compared with an uncoated CVC for clinical tolerability (Adverse Events, AEs) and performance, in order to create a baseline for a large future study. Patients undergoing major surgery, randomised at a 2:1 ratio to BIP CVC (n = 22) or standard CVC (n = 12), were catheterized 9 - 12 days, respectively...
November 6, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29105972/sterilization-effects-on-ultrathin-film-polymer-coatings-for-silicon-based-implantable-medical-devices
#5
Zohora Iqbal, Willieford Moses, Steven Kim, Eun Jung Kim, William H Fissell, Shuvo Roy
Novel biomaterials for medical device applications must be stable throughout all stages of preparation for surgery, including sterilization. There is a paucity of information on the effects of sterilization on sub-10 nm-thick polymeric surface coatings suitable for silicon-based bioartificial organs. This study explores the effect of five standard sterilization methods on three surface coatings applied to silicon: polyethylene glycol (PEG), poly(sulfobetaine methacrylate) (pSBMA), and poly (2-methacryloyloxyethyl phosphorylcholine) (pMPC)...
November 6, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29105970/effects-of-platelet-rich-plasma-on-biological-activity-and-bone-regeneration-of-brushite-based-calcium-phosphate-cement
#6
Md Lemon Hasan, Mirana Taz, Byong-Taek Lee
In this study, we focused on identifying the effects of platelet-rich plasma (PRP) on bioactivity and bone ingrowths incorporated into brushite cement. We introduced PRP as a series of substitutions with an aqueous citrate-ion solution, and the optimized cement with PRP showed no disintegration of the paste consistency. Incorporating PRP showed that the setting time decreased with the increasing of PRP ratios, although the compressive strength was not significantly changed. We evaluated in vitro degradation and bioactivity with the simulated body fluid test, and the result showed that adding PRP accelerated the carbonated apatite nucleation and markedly improved the surface reactivity of the cement...
November 6, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29098785/modulation-of-scar-tissue-formation-in-injured-nervous-tissue-cultivated-on-surface-engineered-coralline-scaffolds
#7
Orly Eva Weiss, Roni Mina Hendler, Eyal Aviv Canji, Tzachy Morad, Maytal Foox, Yitshak Francis, Zvy Dubinski, Ido Merfeld, Liat Hammer, Danny Baranes
Following traumatic brain injury, there is no restoration of the lost nervous tissue, mainly due to the formation of a scar. One promising strategy to overcome this hurdle is grafting scaffolds that can disturb the scar blockade, enabling cell invasion into the wound. The aragonite skeleton of corals is useful scaffolds for testing this strategy, being supportive for neural cells in culture. The purpose of this work was to check if a contact between a coralline scaffold and an injured nervous tissue affects scar formation and if this effect can be regulated by engineering the scaffold's surface topology...
November 3, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29098767/silicon-bioceramic-loaded-with-vancomycin-stimulates-bone-tissue-regeneration
#8
Angel Manchón, Mohammad H Alkhraisat, Carmen Rueda-Rodriguez, Concepción Pintado, J C Prados-Frutos, Jesus Torres, Enrique Lopez Cabarcos
Porous ceramics doped with silicon and pure β-TCP were analyzed in terms of internal microstructure, cell behavior, and the percentage of newly formed bone. Additionally the materials were tested to determine which of the two had better properties to load and release vancomycin hydrochloride. Internal pore distribution and porosity were determined through high pressure mercury porosimetry and the specific surface area was measured by the Brunauer Emmet-Teller method. The proliferation and viability of the human osteoblast-like cell line MG-63 was studied to validate both materials...
November 3, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29098765/enhancing-bone-regeneration-by-combining-mesenchymal-stem-cell-sheets-with-%C3%AE-tcp-col-i-scaffolds
#9
Jun Lin, Jiaqi Shao, Li Juan, Wenke Yu, Xiaojia Song, Pengruofeng Liu, Wenjian Weng, Jinghong Xu, Christian Mehl
The combination of bone marrow-derived mesenchymal stem cells (BMSCs) and biological scaffolds has been demonstrated to be a promising strategy for bone regeneration. However, this method does not result in satisfactory bone regeneration, because the BMSCs are dispersed in the biological scaffolds. The current study developed a new bone regeneration system, which combines synthetic porous three-dimensional scaffolds of β-TCP/COL-I composite with cultured osteogenic sheets of BMSCs. Activity of alkaline phosphatase (ALP), a marker of bone regeneration, was assayed in vitro using enzyme-linked immunosorbent assays and quantitative real-time polymerase chain reaction...
November 3, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29098762/photofunctionalization-of-anodized-titanium-surfaces-using-uva-or-uvc-light-and-its-effects-against-streptococcus-sanguinis
#10
Sakshi Jain, Randall S Williamson, Mary Marquart, Amol V Janorkar, Jason A Griggs, Michael D Roach
UV light preirradiation of anodized titanium oxide layers has recently been shown to produce a photocatalytic effect that may reduce early bacterial attachment on titanium surfaces. Streptococcus species have been identified as primary early colonizers and contribute to early biofilm formation on dental implant surfaces. Anodized layers with primarily amorphous, primarily anatase, primarily rutile, and mixtures of anatase and rutile phase oxides were preirradiated with UVA or UVC light for 10 min. Nanoscale surface roughness and pre- and post-UV-irradiated wettability were measured for each anodization group...
November 3, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29087028/fabrication-of-bioactive-fiber-reinforced-peek-and-mxd6-by-incorporation-of-precursor-of-apatite
#11
Takeshi Yabutsuka, Keito Fukushima, Tomoko Hiruta, Shigeomi Takai, Takeshi Yao
We aimed to develop an effective process to provide bioactivity to carbon fiber-reinforced polyetheretherketone (PEEK), glass fiber-reinforced PEEK and glass fiber-reinforced poly(m-xylyleneadipamide)-6 (MXD6), possessing similar elastic modulus to cortical bone in this study. First, we formed fine pores on the surface of each substrate by a short-time sulfuric acid treatment. Second, in order to provide hydrophilic property, we treated the surfaces of each substrate with oxygen plasma. Finally, we deposited fine particles of amorphous calcium phosphate (PrAp) in the pores by soaking each substrate in SBF adjusted at pH 8...
October 31, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29087024/fibrogenic-and-angiogenic-commitments-of-human-induced-pluripotent-stem-cells-derived-mesenchymal-stem-cells-in-connective-tissue-growth-factor-delivering-scaffold-in-an-immune-deficient-mice-model
#12
Ruodan Xu, Frederik Dagnaes-Hansen, Lise Wogensen, Susanne Maigaard Axelsen, Dror Seliktar, Menglin Chen
Compared to terminal differentiated cells, stem cells play important roles in the maintenance and regeneration, and thus have been intensively researched as the most promising cell based therapy. In order to maximize the effectiveness of stem cell based therapies, it is essential to understand the environmental (niche) signals that regulate stem cell behavior. Recent findings suggest that fibroblasts have a mesenchymal origin and that mesenchymal stem cells (MSCs) demonstrate proangiogenic function, where both fibrogenic and angiogenic activities are associated with connective tissue growth factor (CTGF), a matricellular protein that serves as an essential mediator of skeletogenesis in development and vascular remodeling...
October 31, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29087014/controlled-release-of-paclitaxel-using-a-drug-eluting-stent-through-modulation-of-the-size-of-drug-particles-in-vivo
#13
Bu Nam Jang, Sung Nam Kang, Tae-Gwan Eom, Dong Keun Han, Sang-Hyun An, Insup Noh, Chang Hun Kum
Drug-eluting stents (DESs) are generally used in percutaneous coronary intervention. Paclitaxel (PTX) is widely used in DESs to suppress neointima, which causes restenosis. However, the PTX release profile is slow owing to its hydrophobic properties, resulting in negative effects on re-endothelialization in vessels. In this study, we assessed the effects of the controlled release of PTX particles of specific sizes on in-stent restenosis (ISR). PTX particle sizes were controlled by adjusting the evaporating temperature of the solvent from 25 to 80°C during ultrasonic coating, and DESs were prepared...
October 31, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29083526/in-vitro-evaluation-of-marrow-clot-enrichment-on-microstructure-decoration-cell-delivery-and-proliferation-of-porous-titanium-scaffolds-by-selective-laser-melting-three-dimensional-printing
#14
Qing-Qiang Yao, Jun Hu, Peng-Fei Zheng, Jia-Yi Li, Jin Zhou, Shu-Chang Tian, Bo Wei, Yan Xu, Li-Ming Wang
Titanium alloy is a clinically approved material for bone substitution. Although three-dimensional printing (3DP) fabrication technique can build up porous Ti scaffolds with the designed shape and microstructure, the biomechanical performance of 3DP Ti scaffolds still need to be improved to increase the reliability of osseointegration capacity. To address this issue, rabbit bone marrow clot (MC) is used to modify 3DP Ti scaffolds by stem cell delivery and microenvironment decoration inside the pores of these scaffolds...
October 30, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29080388/review-and-approval-of-medical-devices-in-china-changes-and-reform
#15
Wenbo Liu, Xinli Shi, Zhong Lu, Lanming Wang, Kai Zhang, Xingdong Zhang
The 4th US-China Joint Workshop on Regulation, Standards and Innovation of Biomaterials was held during the Annual Meeting of the Society for Biomaterials on April 5, 2017 at Minneapolis, MN. This series of joint workshops have become a unique platform for both the US and China to discuss and update what is new in the field of biomaterials and medical devices in terms of regulation, standards and innovation since 2013. China Food and Drug Administration and its affiliated agencies such as Center for Medical Device Evaluation presented at each of the workshop...
October 28, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29076293/surface-reactivity-of-octacalcium-phosphate-derived-fluoride-containing-apatite-in-the-presence-of-polyols-and-fluoride
#16
Sei Tsutsui, Takahisa Anada, Yukari Shiwaku, Kaori Tsuchiya, Hajime Yamazaki, Osamu Suzuki
The present study was designed to characterize co-precipitated fluoridated apatitic materials from octacalcium phosphate (OCP) precursor and to investigate their surface reactions with polyols including glycerol in the presence of fluoride ions. Laboratory-synthesized fluoridated apatite crystals (LS-FA) were obtained in a solution containing fluoride (F) from 25 to 500 ppm. LS-FAs and commercially available fluoroapatite (FA) and hydroxyapatite (HA) were characterized by physical techniques, such as X-ray diffraction...
October 27, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29076251/extracorporeal-magnetic-approach-to-reduce-the-unwanted-side-effects-and-improve-antibacterial-activity-of-ag-fe3-o4-nanocomposites-in-rat
#17
Chao Chen, Dong-Lin Xia, Ling-Yan Guo, Yan-Pei Chen, Xiao-Dong Li, Yu-Fei Wang, Duo Zhang, Yu-Ying Wang, Yu-Xin Zhang, Hong He, Hai-Ying Gu
While Ag nanoparticles hold great promise for broad spectrum antibacterial activity, the potential risks of Ag nanoparticles (NPs) on human health remain a challenge. In this study, Ag/Fe3 O4 composites have been successfully prepared and characterized by transmission electron microscopy, X-ray powder diffraction, and Fourier-transform infrared spectroscopy, and their magnetic and antibacterial properties have been assessed. In vivo results show that the antibacterial effect of 500 μg/mL Ag/Fe3 O4 nanocomposites was significantly higher than that of 1000 μg/mL AgNPs after 72 h of treatment (p < 0...
October 27, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29068568/stimulation-of-a-calcified-cartilage-connecting-zone-by-gdf-5-augmented-fibrin-hydrogel-in-a-novel-layered-ectopic-in-vivo-model
#18
Solvig Diederichs, Yvonne Renz, Sébastien Hagmann, Benedict Lotz, Elisabeth Seebach, Wiltrud Richter
Tissue engineering approaches for reconstructing full-depth cartilage defects need to comprise a zone of calcified cartilage to tightly anchor cartilage constructs into the subchondral bone. Here, we investigated whether growth and differentiation factor-5-(GDF-5)-augmented fibrin hydrogel can induce a calcified cartilage-layer in vitro that seamlessly connects cartilage-relevant biomaterials with bone tissue. Human bone marrow stromal cells (BMSCs) were embedded in fibrin hydrogel and subjected to chondrogenesis with TGF-β with or without GDF-5 before constructs were implanted subcutaneously into SCID mice...
October 25, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29068557/in-vitro-study-on-the-deterioration-of-polypropylene-hernia-repair-meshes
#19
Dmitry Gil, James Rex, Vladimir Reukov, Alexey Vertegel
Despite the relative safety of the procedure, hernia repairs are often associated with chronic post-operative pain. Although this complication has been linked among others to mesh deterioration, details of the processes that lead this deterioration are still unknown. This work aims to bridge this gap by analyzing the chemical, physical and structural alterations in hernia repair meshes exposed to oxidative stress in vitro. Here, we developed a methodology to characterize effect of oxidation stress on structure and properties of polymeric hernia repair meshes...
October 25, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29068537/anti-fibrotic-function-of-cu-bearing-stainless-steel-for-reducing-recurrence-of-urethral-stricture-after-stent-implantation
#20
Jing Zhao, Ling Ren, Meixia Liu, Tong Xi, Bingchun Zhang, Ke Yang
Recurrent stenosis is the main reason inducing the failure of urethral stricture treatment. Our previous study has found that the 316L type Cu bearing stainless steel (316L-Cu SS) showed antimicrobial activity and anti-encrustation performance when it was used for relieving urethral obstructer. However, whether it can reduce the occurrence of fibrosis or not, we need further investigation to compare the cellular and molecular responses of human urethral scar fibroblast cells (USFCs) on 316L-Cu SS and medical grade 316L stainless (316L SS, as a control)...
October 25, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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