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Journal of Biomedical Materials Research. Part B, Applied Biomaterials

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https://www.readbyqxmd.com/read/30230711/sliding-behavior-of-zirconia-porous-implant-surfaces-against-bone
#1
T A Dantas, S Roedel, J Mesquita-Guimarães, P Pinto, J C M Souza, M C Fredel, F S Silva, B Henriques
Different zirconia porous layers were produced on zirconia dense zirconia substrates by slip casting using powder with different mean sizes: 40 μm (Z40), 70 μm (Z70), and 100 μm (Z100). The dynamic and static coefficients of friction against bovine femoral bone, mimicking the implantation process, were conducted using a ball-on-flat reciprocating sliding tribometer under 3 N of normal load. Additionally, the porous layers were assessed with regard to their low temperature degradation (aging). Results revealed that the porous layers were able to keep their integrity during the sliding testes against bone, with no zirconia particles being transferred to the bone...
September 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30230685/antibacterial-3d-bone-scaffolds-for-tissue-engineering-application
#2
Jitendra Pant, Jaya Sundaram, Marcus J Goudie, Dieu Thao Nguyen, Hitesh Handa
Open bone fractures are not only difficult to heal but also are at a high risk of infections. Annual cases of fractures which result from osteoporosis amount to approximately 9 million. Endogenously released nitric oxide (NO) has been shown to play a role in osteogenic differentiation in addition to eradicating infection against a wide variety of pathogens. In the current work, antimicrobial NO releasing 3D bone scaffolds were fabricated using S-nitroso-N-acetyl-penicillamine (SNAP) as the NO donor. During fabrication, nano-hydroxyapatite (nHA) was added to each of the scaffolds in the concentration range of 10-50 wt % in nHA-starch-alginate and nHA-starch-chitosan scaffolds...
September 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30230684/industrial-scale-fabrication-of-an-osteogenic-and-antibacterial-pla-silver-loaded-calcium-phosphate-composite-with-significantly-reduced-cytotoxicity
#3
Shaobo Cai, Behnam Pourdeyhimi, Elizabeth G Loboa
In this study, we report an industrial-scale fabrication method of a multifunctional polymer composite as a scaffold material for bone tissue engineering. This study successfully demonstrated the potential of applying industrial polymer processing technologies to produce specially functionalized tissue engineering scaffolds. With the inclusion of a newly synthesized multifunctional additive, silver-doped-calcium phosphate (silver-CaP), the composite material exhibited excellent osteogenic inducibility of human adipose-derived stem cells (hASC) and satisfactory antibacterial efficacy against Escherichia coli and Staphylococcus aureus...
September 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30230682/a-fibrin-coated-pericardial-extracellular-matrix-prevented-heart-adhesion-in-a-rat-model
#4
Seiichi Funamoto, Yoshihide Hashimoto, Akio Kishida, Jun Negishi
As most surgical treatments pose a risk of tissue adhesion, methods to prevent adhesion are needed across various surgical fields. In this study, we investigated the use of a decellularized pericardium with fibrin glue to prevent rat heart adhesion. Porcine pericardia were decellularized by a high-hydrostatic pressure method. Cells adhered to the resulting pericardial extracellular matrix (ECM) during an in vitro cell-seeding test, but fibrin-coated pericardial ECM showed reduced cell adhesion. In a rat surgical model of heart adhesion, the fibrin-coated pericardial ECM did not adhere to the heart and mesothelial cell adhesion was observed on the ECM surface...
September 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30199611/anti-flt1-peptide-and-cyanine-conjugated-gold-nanoparticles-for-the-concurrent-antiangiogenic-and-endothelial-cell-proton-treatment
#5
Seung-Jun Seo, Se-Hee Lee, Ki-Hong Kim, Jong-Ki Kim
Anti-Flt1 peptide of GNQWFI binds to vascular endothelial growth factor receptor 1 (VEGFR1 or Flt1) and prevents binding of VEGF, inhibiting VEGFR1-mediated endothelial cell migration and tube formation. Bare gold nanoparticle (AuNP) was known to have anti-angiogenic properties by specific binding with VEGF. In this study, anti-Flt1 peptide (GGNQWFI) and cyanine were chemically conjugated to AuNPs (Flt1@AuNP-cyanine 5.5 or Flt1@AuNP-hydrocyanine 5.5 [HCy5.5]) to enhance antiangiogenic properties with targeting to VEGFR-1 as well as producing Coulomb nanoradiator therapeutic effect on the retinal endothelial cells...
September 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30199609/evaluation-of-dehydrated-human-umbilical-cord-biological-properties-for-wound-care-and-soft-tissue-healing
#6
Jenn D Bullard, Jennifer Lei, Jeremy J Lim, Michelle Massee, Anna M Fallon, Thomas J Koob
Chronic wounds are a significant health care problem with serious implications for quality of life because they do not properly heal and often require therapeutic intervention. Amniotic membrane allografts have been successfully used as a biologic therapy to promote soft tissue healing; however, the umbilical cord, another placental-derived tissue, has also recently garnered interest because of its unique composition but similar placental tissue origin. The aim of this study was to characterize PURION® PLUS Processed dehydrated human umbilical cord (dHUC) and evaluate the biological properties of this tissue that contribute to healing...
September 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30199604/simultaneous-transcriptome-and-proteome-analysis-of-ea-hy926-cells-under-stress-conditions-induced-by-nanomaterials
#7
Piotr Komorowski, Małgorzata Siatkowska, Tomasz Wasiak, Katarzyna Działoszyńska, Sylwia Kotarba, Kinga Kądzioła, Nina Bartoszek, Paulina Sokołowska, Marcin Elgalal, Anna Sobol-Pacyniak, Krzysztof Makowski, Bogdan Walkowiak
Today, the extensive and constantly growing number of applications in the field of nanotechnology poses a lot of questions about the potential toxicity of nanomaterials (NMs) toward cells of different origins. In our work we employed the tools of molecular biology to evaluate changes that occur in human endothelial cells at the transcriptomic and proteomic level, following 24 h of exposure to three different classes of NMs. Using microarray technology, we demonstrated that 24 h of exposure to silver nanoparticles (SNPs), multiwalled carbon nanotubes (MWCNTs) and polyamidoamine dendrimers (PAMAMs) leads to changes in 299, 1271, and 431 genes, respectively, influencing specific molecular pathways...
September 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30199603/in-vivo-evaluation-of-resorbable-supercritical-co-2-treated-collagen-membranes-for-class-iii-furcation-guided-tissue-regeneration
#8
Nick Tovar, Lukasz Witek, Rodrigo Neiva, Heloisa F Marão, Luiz F Gil, Pablo Atria, Ryo Jimbo, Eduardo A Caceres, Paulo G Coelho
The study evaluated the effects of a Supercritical CO2 (scCO2 ) on a commercially available decellularized/delipidized naturally derived porcine pericardium collagen membrane, Vitala®. The Vitala® and scCO2 treated experimental membranes were evaluated for guided tissue regeneration (GTR) of periodontal tissue in class III furcation defects utilizing a dog model. Physical material characterization was performed by scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC)...
September 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30199602/successful-bony-integration-of-a-porous-tantalum-implant-despite-longlasting-and-ongoing-infection-histologic-workup-of-an-explanted-shoulder-prosthesis
#9
Peter Wahl, Christoph M Sprecher, Christian Brüning, Christoph Meier, Stefan Milz, Emanuel Gautier, T Fintan Moriarty
Infection associated with an implant is a complication feared in surgery, as it leads to loosening and dysfunction. This report documents an unexpected good bony integration of a porous tantalum shoulder prosthesis despite infection. A shoulder prosthesis with a porous tantalum glenoidal base plate was retrieved after 3 years of ongoing infection with Staphylococcus spp. Methyl-methacrylate embedded sections of the retrieved glenoidal component were analyzed by optical and scanning electron beam microscopy (SEM)...
September 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30199601/sol-gel-bioglasses-in-dental-and-periodontal-regeneration-a-systematic-review
#10
REVIEW
Vincenzo Farano, Jean-Christophe Maurin, Nina Attik, Phil Jackson, Brigitte Grosgogeat, Kerstin Gritsch
Due to their osteoconductive and osteoinductive abilities, bioglasses (BGs) have attracted attention in tissue engineering, especially for mineralized tissue. The aim of this study is to review the current state of the art on the effects of BGs produced by sol-gel on cells for dental and periodontal regeneration. The study also discusses associated antibacterial properties. The research was performed by considering the Preferred Reporting Items for Systematic Reviews and the Meta-Analyses (PRISMA) statement...
September 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30199600/the-effect-of-collector-type-on-the-physical-chemical-and-biological-properties-of-polycaprolactone-gelatin-nano-hydroxyapatite-electrospun-scaffold
#11
Mansoureh Sattary, Mohammad Rafienia, Mohammad Taghi Khorasani, Hossein Salehi
Electrospinning is considered a powerful method for the production of fibers in the nanoscale size. Small pore size results in poor cell infiltration, cell migration inhibition into scaffold pores and low oxygen diffusion. Electrospun polycaprolactone/gelatin/nano-hydroxyapatite (PCL/Gel/nHA) scaffolds were deposited into two types of fiber collectors (novel rotating disc and plate) to study fiber morphology, chemical, mechanical, hydrophilic, and biodegradation properties between each other. The proliferation and differentiation of MG-63 cells into the bone phenotype were determined using MTT method, alizarin red staining and alkaline phosphatase (ALP) activity...
September 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30199599/a-novel-method-for-continuous-formation-of-cord-like-collagen-gels-to-fabricate-durable-fibers-in-which-collagen-fibrils-are-longitudinally-aligned
#12
Shunji Yunoki, Hirosuke Hatayama, Mizue Ebisawa, Eiji Kondo, Kazunori Yasuda
We developed a continuous formation method of cord-like collagen gels comprising fibrils preferentially aligned along the geometrical axes (CCGs). Collagen (2.5%) dissolved in a sodium phosphate buffer containing 280 mM of sodium chloride was introduced into a stainless cylinder (length 52 mm, diameter 2.0 mm) warmed at 38°C at a linear velocity of 2.5 mm/s. This process caused collagen fibril alignments under acute fibril formation in the cylinder, resulting in continuous formation of CCGs. Fibril formation rate, shear rate, and shear duration were substantial factors for successful CCG formation...
September 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30199597/physicochemical-and-biological-properties-of-novel-chlorhexidine-loaded-nanotube-modified-dentin-adhesive
#13
Sabrina A Feitosa, Jadesada Palasuk, Saulo Geraldeli, Lester Jack Windsor, Marco C Bottino
A commercially available three-step (etch-and-rinse) adhesive was modified by adding chlorhexidine (CHX)-loaded nanotubes (Halloysite®, HNT) at two concentrations (CHX10% and CHX20%). The experimental groups were: SBMP (unmodified adhesive, control), HNT (SBMP modified with HNT), CHX10 (SBMP modified with HNT loaded with CHX10%), and CHX20 (SBMP modified with HNT loaded with CHX20%). Changes in the degree of conversion (DC%), Knoop hardness (KHN), water sorption (WS), solubility (SL), antimicrobial activity, cytotoxicity, and anti-matrix metalloproteinase [MMP-1] activity (collagenase-I) were evaluated...
September 10, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30195262/cellular-response-to-3-d-printed-bioactive-silicate-and-borosilicate-glass-scaffolds
#14
Weitao Jia, Grace Y Lau, Wenhai Huang, Changqing Zhang, Antoni P Tomsia, Qiang Fu
The repair and regeneration of loaded segmental bone defects is a challenge for both materials and biomedical science communities. Our recent work demonstrated the capability of bioactive glass in supporting bone healing and defect bridging using a rabbit femur segmental defect model without growth factors or bone marrow stromal cells (BMSCs). Here in the current work, a comprehensive in vitro evaluation of bioactive silicate (13-93) and borosilicate (2B6Sr) glass scaffolds was conducted to provide further understanding of their biological performances and to establish a correlation between in vitro and in vivo behaviors...
September 8, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30194906/bone-morphogenic-protein-expression-and-bone-formation-are-induced-by-bioactive-glass-s53p4-scaffolds-in-vivo
#15
Robert Björkenheim, Gustav Strömberg, Mari Ainola, Peter Uppstu, Laura Aalto-Setälä, Leena Hupa, Jukka Pajarinen, Nina C Lindfors
The two-stage induced-membrane (IM) technique is increasingly used for treatment of large bone defects. In stage one, the bone defect is filled with polymethylmethacrylate (PMMA), which induces a membrane around the implant. In stage two, PMMA is replaced with bone graft. Bioactive glasses (BAGs) are bone substitutes with bone-stimulating and angiogenic properties. We have previously shown that a certain type of BAG can also induce a foreign-body membrane similar to PMMA. The aim of this study was to evaluate the bone-forming capacity of sintered BAG-S53P4 and poly(lactide-co-glycolide) (PLGA)-coated BAG-S53P4 scaffolds for potential use as bone substitutes in a single-stage IM technique...
September 8, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30194897/advanced-inorganic-nanocomposite-for-decontaminating-titanium-dental-implants
#16
Ashwaq A Al-Hashedi, Marco Laurenti, Mohamed Amine Mezour, Tayebeh Basiri, Heithem Touazine, Mohamed Jahazi, Faleh Tamimi
Oral hygiene and regular maintenance are crucial for preserving good peri-implant health. However, available prophylaxis products and toothpastes, which are optimized for cleaning teeth, tend to contaminate and abrade implant surfaces due to their organic components and silica microparticles, respectively. This study aims to develop an organic-free implant-paste based on two-dimensional nanocrystalline magnesium phosphate gel and hydrated silica nanoparticles (20-30% w/w) for cleaning oral biofilm on titanium dental implants...
September 8, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30189112/modification-of-silicone-elastomers-with-bioglass-45s5%C3%A2-increases-in-ovo-tissue-biointegration
#17
Nicholas H Cohrs, Konstantin Schulz-Schönhagen, Dirk Mohn, Petra Wolint, Gabriella Meier Bürgisser, Wendelin J Stark, Johanna Buschmann
Silicone is an important material family used for various medical implants. It is biocompatible, but its bioinertness prevents cell attachment, and thus tissue biointegration of silicone implants. This often results in constrictive fibrosis and implant failure. Bioglass 45S5® (BG) could be a suitable material to alter the properties of silicone, render it bioactive and improve tissue integration. Therefore, BG micro- or nanoparticles were blended into medical-grade silicone and 2D as well as 3D structures of the resulting composites were analyzed in ovo by a chick chorioallantoic membrane (CAM) assay...
September 6, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30184333/the-use-of-electrochemical-techniques-to-evaluate-the-corrosion-performance-of-metallic-biomedical-materials-and-devices
#18
REVIEW
Bruce G Pound
The corrosion performance of metallic biomedical materials and devices is commonly evaluated using electrochemical techniques. Although test standards involving such techniques have been released to address some forms of corrosion, a key issue is application of the results with regard to use of an implantable device in vivo. This review focuses on nitinol, 316L/LVM stainless steel, and Co-Cr alloys and is intended to provide some perspective on the significance of results from tests concerning general corrosion, localized corrosion, galvanic corrosion, and fretting corrosion of these alloys in simulated physiological solutions...
September 5, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30184332/a-test-method-to-assess-the-contribution-of-fluid-shear-stress-to-the-cleaning-of-reusable-device-surfaces
#19
Prasanna Hariharan, Sai Sameer Paruchuri, L D Timmie Topoleski, Jean E Rinaldi, Jon P Casamento, Matthew R Myers, Oleg Vesnovsky
Adequate cleaning of reusable medical devices is critical for preventing cross-infection among patients. For reusable medical devices, cleaning using mechanical brushes and detergent may not be sufficient to completely remove the infectious contaminants from the surfaces. This study evaluates the role of fluid flow-induced shear stress in the detachment and removal of contaminants from device surfaces. A stainless-steel test coupon, acting as a surrogate for a device surface, was coated with artificial clot of varying mass...
September 5, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30184331/enhancing-mechanical-properties-of-an-injectable-two-solution-acrylic-bone-cement-using-a-difunctional-crosslinker
#20
Michael J Wiegand, Kennedy L Faraci, Brittany E Reed, Julie M Hasenwinkel
Two-solution bone cements modified with ethylene glycol-dimethacrylate (EG-DMA) as a crosslinker have been developed as an attempt to further improve the mechanical properties of acrylic bone cement. The result of this study shows that EG-DMA can increase the mechanical properties and fractional monomer conversion while preserving the thermal characteristics. The strength and bending modulus increase with EG-DMA concentrations at 5-10 vol % EG-DMA. Substituting the EG-DMA content past 10 vol % decreases the bending properties due to the effects of reduced monomer concentrations...
September 5, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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