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Journal of Biomedical Materials Research. Part B, Applied Biomaterials

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https://www.readbyqxmd.com/read/28199046/bone-regeneration-in-a-rabbit-critical-femoral-defect-by-means-of-magnetic-hydroxyapatite-macroporous-scaffolds
#1
A Russo, M Bianchi, M Sartori, M Boi, G Giavaresi, D M Salter, M Jelic, M C Maltarello, A Ortolani, S Sprio, M Fini, A Tampieri, M Marcacci
Magnetic scaffolds have recently attracted significant attention in tissue engineering due to the prospect of improving bone tissue formation by conveying soluble factors such as growth factors, hormones, and polypeptides directly to the site of implantation, as well as to the possibility of improving implant fixation and stability. The objective of this study was to compare bone tissue formation in a preclinical rabbit model of critical femoral defect treated either with a hydroxyapatite (HA)/magnetite (90/10 wt %) or pure HA porous scaffolds at 4 and 12 weeks after implantation...
February 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28194931/influence-of-scaffold-design-on-3d-printed-cell-constructs
#2
Auryn Souness, Fernanda Zamboni, Gavin M Walker, Maurice N Collins
Additive manufacturing is currently receiving significant attention in the field of tissue engineering and biomaterial science. The development of precise, affordable 3D printing technologies has provided a new platform for novel research to be undertaken in 3D scaffold design and fabrication. In the past, a number of 3D scaffold designs have been fabricated to investigate the potential of a 3D printed scaffold as a construct which could support cellular life. These studies have shown promising results; however, few studies have utilized a low-cost desktop 3D printing technology as a potential rapid manufacturing route for different scaffold designs...
February 14, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28194875/nanophase-bone-substitute-for-craniofacial-load-bearing-application-pilot-study-in-the-rodent
#3
Jonathan Z Baskin, Yohannes Soenjaya, James McMasters, Alvin Ko, Amit Vasanji, Nathan Morris, Steven J Eppell
An exploratory pilot study shows that a rodent mandibular defect model is useful in determining the biological response to a nanophase collagen/apatite composite designed as a biomimetic load-bearing bone substitute. Using a critical size defect, eight groups of rats (n = 3) were implanted with four renditions of the nanophase bone substitute (NBS) biomaterial. Each rendition was tested with and without recombinant human bone morphogenetic protein 2 (BMP2). NBS biomaterial renditions were: baseline, hyper-densified, d-ribose crosslinked, and d-ribose crosslinked and hyper-densified...
February 14, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28194874/preparation-and-characterization-of-a-silk-fibroin-calcium-sulfate-bone-cement
#4
Fuzhan Zhang, Hai Zhu, Genlin Wang, Jile Xie, Yunxia Tao, Wei Xia, Huilin Yang
This study aimed to prepare and characterize a silk fibroin/calcium sulfate (SF/CS) bone cement. SF solutions of the following concentrations 3, 4.5, 6, 7.5, and 9 g/L were used to prepare bone cement samples with SF-to-CS ratios of 0.35, 0.40, 0.45, 0.50, and 0.55 mL of SF solutions (or water as control) per g of CS. Compressive strength, setting time, degradation when immersed in phosphate-buffered saline, X-ray diffraction, Fourier infrared spectroscopy, and scanning electron microscopy were used to characterize the SF/CS bone cement...
February 14, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28194860/a-review-of-decellurization-methods-caused-by-an-urgent-need-for-quality-control-of-cell-free-extracellular-matrix-scaffolds-and-their-role-in-regenerative-medicine
#5
REVIEW
Marek Kawecki, Wojciech Łabuś, Agnieszka Klama-Baryla, Diana Kitala, Malgorzata Kraut, Justyna Glik, Marcelina Misiuga, Mariusz Nowak, Tomasz Bielecki, Aleksandra Kasperczyk
The natural extracellular matrix (ECM),thanks to its specific properties (e.g., collagenous lattice, a reservoir of growth factors, ECM-cell anchoring areas, an optimal pH and CO2 ),ensures an optimal microenvironment for homeostatic and regenerative cell development. In the context of regenerative medicine, ECM is a lair for residual and infiltrative cells. The aim of the clinical usage of cell-free ECM scaffolds is the enhancement of tissue regeneration with possible minimization of an adverse host reaction on allogeneic or xenogeneic biomaterial...
February 14, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28188976/influence-of-hypoxia-on-the-stemness-of-umbilical-cord-matrix-derived-mesenchymal-stem-cells-cultured-on-chitosan-films
#6
Takashi Taguchi, Jane Y Cho, Jijun Hao, Yvette S Nout-Lomas, Kyung-Sun Kang, Dominique J Griffon
Chitosan is attractive as a substrate for stem cell expansion because it improves stemness through formation of spheroids. Hypoxia has also been proposed as a strategy to enhance stemness and survival of stem cells after in vivo implantation. This study was therefore designed to evaluate the influence of hypoxia on chitosan-induced behavior of stem cells. Umbilical cord matrix-derived stem cells were cultured on chitosan film or standard plate under normoxia and hypoxia, for 3 and 7 days. Based on immunophenotyping, chitosan strongly suppresses the expression of CD90 and CD105 cell surface markers, changes partially reversed by combined exposure to hypoxia...
February 11, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28186709/in-vitro-evaluation-of-the-biological-compatibility-and-antibacterial-activity-of-a-bone-substitute-material-consisting-of-silver-doped-hydroxyapatite-and-bio-oss-%C3%A2
#7
Jingjue Gong, Lei Yang, Qi He, Ting Jiao
This study evaluated biological compatibility and antibacterial activity of a bone substitute material consisting of silver-doped hydroxyapatite (AgHA) and Bio-Oss(®) with different mixture ratios in vitro and investigated its antibacterial mechanism. AgHA was synthesized by a chemical precipitation method. After characterization, AgHA was mixed with Bio-Oss(®) at three ratios: 1:1, 1:2, and 1:4 by weight. Then, Porphyromonas gingivalis (Pg) and Fusobacterium nucleatum (Fn) were used to test the antibacterial activity of the mixture...
February 10, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28186696/evaluation-of-freeze-drying-and-cryopreservation-protocols-for-long-term-storage-of-biomaterials-based-on-decellularized-intestine
#8
Eloísa Díaz-Moreno, Daniel Durand-Herrera, Víctor Carriel, Miguel-Ángel Martín-Piedra, María-Del-Carmen Sánchez-Quevedo, Ingrid Garzón, Antonio Campos, Ricardo Fernández-Valadés, Miguel Alaminos
We evaluated the efficiency of several protocols to preserve the main components of decellularized tissue scaffolds for delayed use. Decellularized rat intestine scaffolds were generated by using SDS and triton X-100 and preserved for 3 months subjected to eight freeze-drying (F1 to F8) and 14 cryopreservation protocols (C1 to C14). Morphological analysis showed that cryopreservation tended to preserve the tissue morphostructure more efficiently than freeze-drying. Histological analysis showed that the content of proteoglycans and glycoproteins was efficiently preserved by most methods...
February 10, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28186691/balancing-microbial-and-mammalian-cell-functions-on-calcium-ion-modified-implant-surfaces
#9
Eduardo Anitua, Ricardo Tejero, Miguel Ángel Pacha-Olivenza, María Coronada Fernández-Calderón, María Delgado-Rastrollo, Mari Mar Zalduendo, María Troya, Ciro Pérez-Giraldo, María Luisa González-Martín
Implant integration is a complex process mediated by the interaction of the implant surface with the surrounding ions, proteins, bacteria, and tissue cells. Although most implants achieve long-term bone-tissue integration, preventing pervasive implant-centered infections demands further advances, particularly in surfaces design. In this work, we analyzed classical microrough implant surfaces (only acid etched, AE; sandblasted then acid etching, SB + AE) and a new calcium-ion-modified implant surface (AE + Ca) in terms of soft- and hard-tissue integration, bacterial adhesion, and biofilm formation...
February 10, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28186684/effect-of-different-sustained-bone-morphogenetic-protein-2-release-kinetics-on-bone-formation-in-poly-propylene-fumarate-scaffolds
#10
Maurits G L Olthof, Diederik H R Kempen, James L Herrick, Michael J Yaszemski, Wouter J A Dhert, Lichun Lu
To investigate the effect of sustained bone morphogenetic protein-2 (BMP-2) release kinetics on bone formation in poly(propylene fumarate) (PPF) scaffolds, different poly(lactic-co-glycolic acid) (PLGA) microspheres were used as delivery vehicles. All PPF scaffolds had the same 75% porous structure, while the degradation rate of the embedded PLGA microspheres was changed to tailor BMP-2 release by varying the lactic-to-glycolic acid (L:G) ratio in the copolymer. Four PLGA microsphere formulations with 50/50, 65/35, 75/25, and 85/15 L:G ratios and varying in vivo degradation rates were fabricated...
February 10, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28170157/combining-electrospinning-and-cell-sheet-technology-for-the-development-of-a-multiscale-tissue-engineered-ligament-construct-telc
#11
Cedryck Vaquette, P T Sudheesh Kumar, Eugen Bogdan Petcu, Saso Ivanovski
Ligament tissue rupture is a common sport injury. Although current treatment modalities can achieve appropriate reconstruction of the damaged ligament, they present significant drawbacks, mostly related to reduced tissue availability and pain associated with tissue harvesting. Stem cell based tissue regeneration combined with electrospun scaffolds represents a novel treatment method for torn ligaments. In this study, a low fiber density polycaprolactone (PCL) electrospun mesh and sheep mesenchymal stem cells (sMSCs) were used to develop tissue engineered ligament construct (TELC) in vitro...
February 7, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28165660/comparison-of-elastic-properties-of-open-cell-metallic-biomaterials-with-different-unit-cell-types
#12
Reza Hedayati, Mojtaba Sadighi, Mohammad Mohammadi-Aghdam, Hossein Hosseini-Toudeshky
Additive manufacturing techniques have made it possible to create open-cell porous structures with arbitrary micro-geometrical characteristics. Since a wide range of micro-geometrical features is available for making an implant, having a comprehensive knowledge of the mechanical response of cellular structures is very useful. In this study, finite element simulations have been carried out to investigate the effect of structure unit cell type (cube, rhombic dodecahedron, Kelvin, Weaire-Phelan, and diamond), cross-section type (circular, square, and triangular), strut length, and relative density on the Young's modulus, shear modulus, yield stress, shear yield stress, and Poisson's ratio of open-cell tessellated cellular structures...
February 6, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28160410/mri-compatibility-of-several-early-transition-metal-based-alloys-and-its-influencing-factors
#13
Da-Bo Zhou, Shao-Gang Wang, Shao-Ping Wang, Hong-Jun Ai, Jian Xu
Magnetic resonance imaging (MRI) compatibility of three early transition metal (ETM) based alloys was assessed in vitro with agarose gel as a phantom, including Zr-20Nb, near-equiatomic (TiZrNbTa)90 Mo10 and Nb-60Ta-2Zr, together with pure tantalum and L605 Co-Cr alloy for comparison. The artifact extent in the MR image was quantitatively characterized according to the maximum area of 2D images and the total volume in reconstructed 3D images with a series of slices under acquisition by fast spin echo (FSE) sequence and gradient echo (GRE) sequence...
February 3, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28152274/fe-3-seo42-dual-doped-nano-hydroxyapatite-a-novel-material-for-biomedical-applications
#14
Ammar Z Alshemary, Ahmet Engin Pazarceviren, Aysen Tezcaner, Zafer Evis
Dual ions substituted hydroxyapatite (HA) received attention from scientists and researchers in the biomedical field owing to their excellent biological properties. This paper presents a novel biomaterial, which holds potential for bone tissue applications. Herein, we have successfully incorporated ferric (Fe(3+) )/selenate (SeO42-) ions into the HA structure (Ca10-x-y Fey (PO4 )6-x (SeO4 )x (OH)2-x-y Oy ) (Fe-SeHA) through a microwave refluxing process. The Fe-SeHA materials were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and field emission scanning electron microscopy (FESEM)...
February 2, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28152273/effects-of-tissue-digestion-solutions-on-surface-properties-of-nitinol-stents
#15
Stacey J L Sullivan, Philip Stafford, Elon Malkin, Maureen L Dreher, Srinidhi Nagaraja
Analysis of explanted medical implants can provide a wealth of knowledge about device safety and performance. However, the quality of information may be compromised if the methods used to clean tissue from the device disturb the retrieved condition. Common solutions used to digest tissue may adversely affect the surface of the device and its severity can be material and processing dependent. In this study, two groups of stents made from the same material (Nitinol) were shape set in a salt pot (SP) or further processed by mechanical polishing (MP) and then immersed in one of three tissue digestion solutions (TDS): nitric acid (HNO3 ), sodium hydroxide (NaOH), or papain enzyme (papain)...
February 2, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28152268/the-impact-of-gallium-content-on-degradation-bioactivity-and-antibacterial-potency-of-zinc-borate-bioactive-glass
#16
Alireza Rahimnejad Yazdi, Lawrence Torkan, Wendy Stone, Mark R Towler
Zinc borate glasses with increasing gallium content (0, 2.5, 5, 10, and 15 Wt % Ga) were synthesized and their degradation, bioactivity in simulated body fluid (SBF), and antibacterial properties were investigated. ICP measurements showed that increased gallium content in the glass resulted in increased gallium ion release and decreased release of other ions. Degradability declined with the addition of gallium, indicating the formation of more symmetric BO3 units with three bridging oxygens and asymmetric BO3 units with two bridging oxygens in the glass network as the gallium content in the series increased...
February 2, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28152265/effectiveness-of-anti-oxidant-polyethylene-what-early-retrievals-can-tell-us
#17
Barbara H Currier, John H Currier, Lindsay A Holdcroft, Douglas W Van Citters
The optimum UHMWPE orthopedic implant bearing surface must balance wear, oxidation, and fatigue resistance. Antioxidant polyethylene addresses free radicals, resulting from irradiation used in cross-linking, that could oxidize and potentially lead to fatigue damage under cycles of in vivo use. This study evaluates what short-term antioxidant UHMWPE retrievals can reveal about: (1) oxidation-resistance and (2) fatigue-resistance of these new materials. Retrievals of three different antioxidant polyethylene materials (n = 25) were analyzed by FTIR and uniaxial tensile tests and compared to conventional (n = 20) and remelted highly cross-linked (n = 30) polyethylene retrievals of similar in vivo duration...
February 2, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28152262/structural-analysis-of-fluorine-containing-bioactive-glass-nanoparticles-synthesized-by-sol-gel-route-assisted-by-ultrasound-energy
#18
Carolina E C Lins, Agda A R Oliveira, Ismael Gonzalez, Waldemar A A Macedo, Marivalda M Pereira
In the last decades, studies about the specific effects of bioactive glass on remineralization of dentin were the focus of attention, due to their excellent regenerative properties in mineralized tissues. The incorporation of Fluorine in bioactive glass nanoparticles may result in the formation of fluorapatite (FAP), which is chemically more stable than hydroxyapatite or carbonated hydroxyapatite, and therefore is of interest for dental applications. The aim of this study was to synthesize and characterize a new system of Fluorine-containing bioactive glass nanoparticles (BGNPF)...
February 2, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28140524/micropatterning-of-reagent-free-high-energy-crosslinked-gelatin-hydrogels-for-bioapplications
#19
Benedikt Heyart, Astrid Weidt, Emilia I Wisotzki, Mareike Zink, Stefan G Mayr
Hydrogels are crosslinked polymeric gels of great interest in the field of tissue engineering, particularly as biocompatible cell or drug carriers. Reagent-free electron irradiated gelatin is simple to manufacture, inexpensive and biocompatible. Here, the potential to micropattern gelatin hydrogel surfaces during electron irradiation crosslinking was demonstrated as a promising microfabrication technique to produce thermally stable structures on highly relevant length scales for bioapplications. In the present work, grooves of 3...
January 31, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28140522/hybrid-extracellular-matrix-design-for-cartilage-mediated-bone-regeneration
#20
Paiyz E Mikael, Hyun S Kim, Syam P Nukavarapu
Recapitulating long bone repair through endochondral ossification (EO) is increasingly becoming a more popular approach. A successful EO Process depends greatly on the establishment of a healthy hypertrophic-cartilage template (HCT). The aim of this work is to design a hydrogel system, which closely mimics the extracellular matrix of HCT. We examined the combinatorial effect of two commonly used hydrogels for bone and cartilage regeneration strategies, hyaluronan (HA) and fibrin (FB), to induce HCT formation...
January 31, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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