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Journal of Biomedical Materials Research. Part B, Applied Biomaterials

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https://www.readbyqxmd.com/read/30440098/thermo-modulated-hela-cell-release-from-an-elastic-and-biocompatible-hydrogel
#1
Yujing You, Chenhao Tang, Gang Zhang, Zhiqiang Jiang, Zhongda Lv
Cell growth and release from the hydrogel scaffolds are critical steps in cell culture and cell therapies. Herein a double network hydrogel with one thermosensitive P(AEtMA-Cl-DEAEA) network and the other polyacrylamide network is reported. The diad hydrogel is elastic and maintains its structural integrity under large deformation. BSA is adsorbed onto the hydrogel at body temperature and subsequently released from the hydrogel at lower temperature. Hela cells proliferate on the hydrogel scaffolds at 37°C...
November 15, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30419159/polymeric-ionically-conductive-composite-matrices-and-electrical-stimulation-strategies-for-nerve-regeneration-in-vitro-characterization
#2
Ohan S Manoukian, Scott Stratton, Michael R Arul, Joshua Moskow, Naseem Sardashti, Xiaojun Yu, Swetha Rudraiah, Sangamesh G Kumbar
Stem cell strategies and the use of electrical stimulation (ES) represent promising new frontiers for peripheral nerve regeneration. Composite matrices were fabricated by coating electrospun polycaprolactone/cellulose acetate micro-nanofibers with chitosan and ionically conductive (IC) polymers including, sulfonated polyaniline, and lignin sulfonate. These composite matrices were characterized for surface morphology, coating uniformity, ionic conductivity, and mechanical strength to explore as scaffold materials for nerve regeneration in conjunction with ES...
November 12, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30419151/treatment-of-intractable-oral-ulceration-with-an-oral-mucosa-equivalent
#3
Jaewang Lee, Daiha Shin, Jong-Lyel Roh
The current use of steroids or pharmacological immunomodulators for the treatment of intractable oral ulceration is ineffective, necessitating newer cell-based therapeutic approaches. We examined the potential efficacy of an oral mucosa equivalent developed in this study in an in vivo model of repeat major oral ulceration mimicking the intractable oral ulceration observed clinically. Oral mucosal samples and plasma fibrin were obtained from Sprague-Dawley rats. The oral mucosa equivalents were prepared with cultured mucosal keratinocytes and plasma fibrin mixed with cultured fibroblasts...
November 12, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30419146/heart-valve-tissue-derived-hydrogels-preparation-and-characterization-of-mitral-valve-chordae-aortic-valve-and-mitral-valve-gels
#4
Jinglei Wu, Bryn Brazile, Sara R McMahan, Jun Liao, Yi Hong
Heart valve (HV) diseases are among the leading causes of death and continue to threaten public health worldwide. The current clinical options for HV replacement include mechanical and biological prostheses. However, an ongoing problem with current HV prostheses is their failure to integrate with the host tissue and their inability grow and remodel within the body. Tissue engineered heart valves (TEHVs) are a promising solution to these problems, as they are able to grow and remodel somatically with the rest of the body...
November 12, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30408310/corrosion-behavior-and-biocompatibility-evaluation-of-a-novel-zinc-based-alloy-stent-in-rabbit-carotid-artery-model
#5
Song Lin, Xiaolin Ran, Xinhao Yan, Wenhua Yan, Qilong Wang, Tieying Yin, Jack G Zhou, Tingzhang Hu, Guixue Wang
Zinc (Zn) and its alloys have been proved to be promising candidate materials for biodegradable cardiovascular stents. In this study, a novel extruded Zn-0.02 Mg-0.02Cu alloy was prepared. Compared with pure Zn, the Zn-based alloy showed higher mechanical properties, and the Zn-based alloy could significantly accelerate Zn2+ release, reaching 0.61 ± 0.11 μg/mL at 15 days of immersion. In vitro biocompatibility studies demonstrated that the Zn-based alloy had excellent cytocompatibility and hemocompatibility, including low hemolysis rate (0...
November 8, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30388312/the-presence-of-fecal-test-soil-protects-bacteria-during-cleaning-disinfection
#6
Poulomi Nandy, Elizabeth A Gonzalez, Anne D Lucas, Victoria M Hitchins
Reusable medical devices (RMDs) must be reprocessed between uses to render them safe for each use and each patient. Cleaning used devices removes organic and inorganic soil making them either safe for reuse or ready for disinfection/sterilization depending on the device. Although cleaning is an important step in a RMD's life cycle, it is not always a priority during device design. In addition, when performing cleaning validation, it is recommended that the manufacturer takes into consideration, what the most appropriate or worst case conditions are in terms of type of soil or the presence of bacteria...
November 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30383916/design-and-fabrication-of-a-hybrid-alginate-hydrogel-poly-%C3%AE%C2%B5-caprolactone-mold-for-auricular-cartilage-reconstruction
#7
D O Visscher, A Gleadall, J K Buskermolen, F Burla, J Segal, G H Koenderink, M N Helder, P P M van Zuijlen
The aim of this study was to design and manufacture an easily assembled cartilage implant model for auricular reconstruction. First, the printing accuracy and mechanical properties of 3D-printed poly-ε-caprolactone (PCL) scaffolds with varying porosities were determined to assess overall material properties. Next, the applicability of alginate as cell carrier for the cartilage implant model was determined. Using the optimal outcomes of both experiments (in terms of (bio)mechanical properties, cell survival, neocartilage formation, and printing accuracy), a hybrid auricular implant model was developed...
November 1, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30376613/fabrication-microstructure-and-properties-of-a-biodegradable-mg-zn-ca-clip
#8
Hao Bai, Xianghui He, Pengfei Ding, Debao Liu, Minfang Chen
An Mg-Zn-Ca alloy biodegradable clip was fabricated by combining hot extrusion and blanking processing. Microstructure evolution was investigated by optical microscopy and electron backscattering diffraction and the occlusion properties of Mg-Zn-Ca alloy clip were evaluated in vitro and in vivo. It was found that the as-extruded Mg-Zn-Ca alloy exhibited a typical fiber microstructure. After blanking, the basal texture intensity increased because of the work hardening effect. Subsequent annealing treatment of the blanking clip can significantly weaken the texture while improving the ductility of the Mg-Zn-Ca alloy...
October 30, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30367819/a-novel-approach-to-devise-the-therapy-for-ventricular-fibrillation-by-epicardial-delivery-of-lidocaine-using-active-hydraulic-ventricular-attaching-support-system-an-experimental-study-in-rats
#9
Sufia Yasmeen, Xiaoqian Liao, Farhan Ullah Khan, Awais Ullah Ihsan, Xue Li, Cunyu Li, Dingding Chen, Feng Yu, Zhijie Wang, Kiganda Raymond Sembatya, Reyaj Mikrani, Xiaohui Zhou
Active hydraulic ventricular attaching support system (ASD) placed around the heart is not only a novel, nontransplant surgical device used for epicardial administration of drugs like lidocaine, but also a promising treatment option for ventricular fibrillation (VF) and arrhythmias. We hypothesize that lidocaine in 5 mg/kg dose released by ASD significantly improves the VF in the rat model. Sprague-Dawley (SD) rats were selected and were divided into four groups, intravenous injection (IV), epicardial infusion (EI), ASD, and control...
October 27, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30367816/biocompatibility-of-common-implantable-sensor-materials-in-a-tumor-xenograft-model
#10
Mark E Gray, James Meehan, Ewen O Blair, Carol Ward, Simon P Langdon, Linda R Morrison, Jamie R K Marland, Andreas Tsiamis, Ian H Kunkler, Alan Murray, David Argyle
Real-time monitoring of tumor microenvironment parameters using an implanted biosensor could provide valuable information on the dynamic nature of a tumor's biology and its response to treatment. However, following implantation biosensors may lose functionality due to biofouling caused by the foreign body response (FBR). This study developed a novel tumor xenograft model to evaluate the potential of six biomaterials (silicon dioxide, silicon nitride, Parylene-C, Nafion, biocompatible EPOTEK epoxy resin, and platinum) to trigger a FBR when implanted into a solid tumor...
October 27, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30352138/biocompatibility-of-injectable-hydrogel-from-decellularized-human-adipose-tissue-in-vitro-and-in-vivo
#11
Yu Zhao, Jun Fan, Shuling Bai
Adipose tissue engineering is considered as a promising treatment for repairing soft tissue defects. The decellularized extracellular matrix (ECM) is becoming the research focus in tissue engineering for its tissue specificity. In this study, the human adipose tissue liposucted from healthy people were decellularized by a series of mechanical, chemical, and enzymatic methods. The components of cell and lipid were effectively removed, whereas the collagens and other ingredients in adipose tissue were retained in the human decellularized adipose tissue (hDAT)...
October 23, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30339743/freeze-thaw-cycles-for-biocompatible-mechanically-robust-scaffolds-of-human-hair-keratins
#12
Xinxing Cui, Songmei Xu, Wen Su, Zhe Sun, Zeng Yi, Xiaomin Ma, Guangcan Chen, Xiangyu Chen, Bo Guo, Xudong Li
The keratin-based scaffolds are getting more and more attention in the application of tissue engineering. Though various approaches have been considered to improve the physical properties of these scaffolds, few succeeded in achieving the enhanced properties of the pure keratin scaffolds. Due to the presence of -OH, -NH2 , >CO, and -SH on the extracted human hair keratin (HHK), the formation of hydrogen bonds and disulfide bridges could be triggered under certain conditions, leading to the self-cross-linking of HHK materials...
October 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30339742/surface-assembly-of-poly-i-c-on-polyethyleneimine-modified-gelatin-nanoparticles-as-immunostimulatory-carriers-for-mucosal-antigen-delivery
#13
Shen-Fu Lin, Ping-Lun Jiang, Jeng-Shiang Tsai, Yi-You Huang, Shyr-Yi Lin, Jiunn-Horng Lin, Der-Zen Liu
The mucosal immune system is the host's first line of defense against invasion by foreign pathogens. Gelatin nanoparticles (GNPs) are suitable carriers for the delivery of antigens via various routes of administration. In the present study, GNPs were modified with polyethyleneimine (PEI), a positively charged polymer. Then, ovalbumin (OVA) and polyinosinic:polycytidylic acid (poly(I:C)), an immunostimulant, were adsorbed onto the surface of the positively charged GNPs. We assessed whether GNPs could act as an effective mucosal vaccine that is capable of inducing both mucosal and systemic immune responses...
October 19, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30332531/infection-burden-and-immunological-responses-are-equivalent-for-polymeric-and-metallic-implant-materials-in-vitro-and-in-a-murine-model-of-fracture-related-infection
#14
Edward T J Rochford, Marina Sabaté Brescó, Alexandra H C Poulsson, Katharina Kluge, Stephan Zeiter, Mario Ziegler, Liam O'Mahony, Robert Geoff Richards, Thomas Fintan Moriarty
The development of an infection is a major complication for some patients with implanted biomaterials. Whether the material or surface composition of the used biomaterial influences infection has not been directly compared for key biomaterials currently in use in human patients. We conducted a thorough in vitro and in vivo investigation using titanium (Ti) and polyether-ether-ketone (PEEK) as both commercially available and as modified equivalents (surface polished Ti, and oxygen plasma treated PEEK). Complement activation and cytokine secretion of cell of the immune system was assessed in vitro for all materials in the absence and presence of bacterial stimulants...
October 17, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30332525/morphology-induced-physico-mechanical-and-biological-characteristics-of-tpu-pdms-blend-scaffolds-for-skin-tissue-engineering-applications
#15
M P Drupitha, Kamakshi Bankoti, Pallabi Pal, Bodhisatwa Das, Ramesh Parameswar, Santanu Dhara, Golok B Nando, Kinsuk Naskar
Composition and architecture of scaffolds are the most important factors determining the performance of skin substitutes. In this work, morphology induced unique physical and biological characteristics of compatibilized TPU-PDMS blend scaffolds at 90:10, 80:20, and 70:30 blend ratios of TPU and PDMS was studied. The fiber morphology, porosity, surface wettability, and mechanical properties of electrospun scaffolds were distinctly influenced by the presence of PDMS. Interestingly, the scaffold architecture varied from electrospun fibers to porous fibers and finally occurrence of unique porous beads noticed at 30% PDMS in the microstructure which was confirmed using FESEM...
October 17, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30325095/analysis-of-polyvinyl-alcohol-release-from-commercially-available-daily-disposable-contact-lenses-using-an-in-vitro-eye-model
#16
Chau-Minh Phan, Hendrik Walther, Donald Riederer, Charis Lau, Kathrine Osborn Lorenz, Lakshman Nagapatnam Subbaraman, Lyndon Jones
The purpose of this work was to determine the release of polyvinyl alcohol (PVA) from etafilcon A, omafilcon A, and nelfilcon A daily disposable hydrogel contact lenses using a novel in vitro model. PVA is an ocular lubricant that can be found in multiple formulations of artificial tears. Nelfilcon A innately contains PVA, so only the release of PVA from this lens was evaluated. Etafilcon A and omafilcon A lenses were incubated in a PBS solution containing PVA. The release of PVA was evaluated using a novel in vitro blink platform with Milli-Q water and PBS under various blink conditions and flow rates...
October 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30321479/effect-of-oxidation-on-intrinsic-residual-stress-in-amorphous-silicon-carbide-films
#17
Felix Deku, Shakil Mohammed, Alexandra Joshi-Imre, Jimin Maeng, Vindhya Danda, Timothy J Gardner, Stuart F Cogan
The change in residual stress in plasma enhanced chemical vapor deposition amorphous silicon carbide (a-SiC:H) films exposed to air and wet ambient environments is investigated. A close relationship between stress change and deposition condition is identified from mechanical and chemical characterization of a-SiC:H films. Evidence of amorphous silicon carbide films reacting with oxygen and water vapor in the ambient environment are presented. The effect of deposition parameters on oxidation and stress variation in a-SiC:H film is studied...
October 15, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30318825/the-effects-of-substrate-mediated-electrical-stimulation-on-the-promotion-of-osteogenic-differentiation-and-its-optimization
#18
Wei-Wen Hu, Tun-Chi Chen, Chia-Wen Tsao, Yu-Che Cheng
To explore the effect of electrical stimulation (ES) on osteogenesis, a polypyrrole (PPy)-made electrical culture system was developed to provide a direct-current electric field (DCEF). This DCEF device was applied to treat differentiated rat bone marrow stromal cells (rBMSCs) once in different stages of osteo-differentation to investigate its temporal effects. The mineralization results showed that the DCEF treatment not only accelerated cell differentiation but also promoted the saturation levels, and the ES on day 8 was the group demonstrated the optimal result...
October 14, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30318775/reinforcing-materials-for-polymeric-tissue-engineering-scaffolds-a-review
#19
REVIEW
Haleh Bakht Khosh Hagh, Fahimeh Farshi Azhar
Final purpose of tissue engineering is to regenerate or repair damaged tissues or organs. Desired repair efficacy necessitates proper physicochemical performances of scaffolds, among which adequate mechanical properties are crucial. Therefore, reinforcing tissue engineering scaffolds has been a hot research trend in recent years. In this regard, the use of some biomaterials as reinforcing materials is a longstanding area of interest. This article introduces the most popular reinforcing materials and focuses on recent advances in the use of these materials for reinforcing mechanical properties of tissue engineering scaffolds...
October 14, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/30318728/breath-figures-decorated-silicon-oxinitride-ceramic-surfaces-with-controlled-si-ions-release-for-enhanced-osteoinduction
#20
Cristiano Carlomagno, Antonella Motta, Giandomenico Sorarù, Pranesh Aswath, Claudio Migliaresi, Devid Maniglio
Bioactive coatings are usually applied to bone and dental prostheses to enhance the integration and their stability in the bone. Recently, silicon (Si) oxynitride ceramics have been demonstrated to possess osteoconductive properties due to the release of Si ions, particularly important in the early stage of bone formation. In addition, the pattern of the bone contacting surface has been reported to affect cells' differentiation and metabolic activity. In this work, we propose the Breath Figure (BF) process combined with a pyrolysis step, starting from a photo-crosslinkable alkoxy silicone precursor, as a method to realize bioactive patterned coating on metal bone and dental prostheses...
October 14, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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