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Journal of Biomedical Materials Research. Part A

Mozhgan Aghajanzadeh, Mostafa Zamani, Hamid Rashidzadeh, Kobra Rostamizadeh, Ali Sharafi, Hossein Danafar
In this project, a core-shell Polymersome based on miktoarm star-copolymer: methoxy Poly Ethylene Glycol-Lysine-(Poly Caprolactone)2 (PEG-Lys-PCL2 ) was synthesized by a new method as controlled targeted drug delivery systems for co-delivery of the chemotherapeutic methotrexate (MTX) and curcumin (CUR). Some properties of these nano carriers (NCs) such as surface morphology, structure, surface charge, stability and biocompatibility were evaluated by Proton nuclear magnetic resonance (1 HNMR), dynamic scanning colorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), Dynamic light scattering (DLS), atomic force microscopy (AFM), Critical aggregation concentration (CAC), hemolysis test, MTT assay and lethal dose 50 (LD50)...
June 16, 2018: Journal of Biomedical Materials Research. Part A
Natasja Leth Bergholt, Morten Foss, Anwer Saeed, Nikolaj Gadegaard, Helle Lysdahl, Martin Lind, Casper Bindzus Foldager
Understanding the behavior of chondrocytes in contact with artificial culture surfaces is becoming increasingly important in attaining appropriate ex vivo culture conditions of chondrocytes in cartilage regeneration. Chondrocyte transplantation-based cartilage repair requires efficiently expanded chondrocytes and the culture surface plays an important role in guiding the behavior of the cell. Micro- and nanoengineered surfaces make it possible to modulate cell behavior. We hypothesized that the combined influence of topography, substrate, and surface chemistry may affect the chondrocyte culturing in terms of proliferation and phenotypic means...
June 16, 2018: Journal of Biomedical Materials Research. Part A
Maryam Kameli, Reza Khorramirouz, Sahar Eftekharzadeh, Kiarad Fendereski, Seyedeh Sima Daryabari, Seyed Mohammad Tavangar, Abdol-Mohammad Kajbafzadeh
INTRODUCTION: Myocardial infarction (MI) is a major cause of mortality and morbidity in industrialized societies. Myocardial tissue engineering is an alternative and promising approach for substituting injured myocardium through development and seeding of appropriate scaffolds. In this study, we investigated the efficacy of using an acellular pericardium to deliver autologous mesenchymal stem cells (MSCs) to the infarcted site for regeneration of the myocardium. MATERIALS AND METHODS: MI was induced in two groups of rats; G1 or MI group, and G2 or patch-implanted group...
June 14, 2018: Journal of Biomedical Materials Research. Part A
M Nazm Bojnordi, S Ebrahimi-Barough, E Vojoudi, H H Ghasemi
The scaffolds accompanied with stem cells have great potential for applications in neural tissue engineering. Fabrication of Nano fibrous scaffold similar to extracellular matrix is one of the applicable methods in neural tissue regeneration. The aim of this study was the fabrication of a silk Nano fibrous scaffold as a microenvironment for neural guiding differentiation of Embryonic stem like cells (ES Like cells) derived from testis toward neuron-like cells. ES Like derived from culturing of testicular cells in vitro, were seeded on Silk scaffolds and induced to neuronal phenotype using 4-/4± RA technique following culturing the cells in the neurobasal medium supplemented with 20 ng/ml bFGF,10 ng/ml EGF, B27 and N2 for 8-12 days...
June 14, 2018: Journal of Biomedical Materials Research. Part A
Farhad Ghadami, Saeed Saber-Samandari, Gholamreza Rouhi, Mohsen Amani Hamedani, Mohammad Mehdi Dehghan, Saeed Farzad Mohajeri, Fatemeh Mashhadi-Abbas, Hossein Gholami
The main goal of this work was to investigate the effects of implants coatings' mechanical properties and morphology on the osseointegration. In order to produce different mechanical properties of coatings, two thermal spray techniques, high velocity oxy-fuel (HVOF) and air plasma spray (APS) were employed. Titanium pins were coated and implanted into the distal femurs and proximal tibias of fifteen New Zealand white rabbits, equally distributed in three study groups, and a total of twenty pins implanted in each group...
June 14, 2018: Journal of Biomedical Materials Research. Part A
Cheyann Lee Wetteland, Huinan Liu
This article reports a new process for creating polymer-based nanocomposites with enhanced dispersion of ceramic nanoparticles without using any surfactants, and the resulted changes in their optical and biological properties. Specifically, dispersion of two different ceramic nanoparticles, i.e, hydroxyapatite (nHA) and magnesium oxide (nMgO) nanoparticles, in a model biodegradable polymer, namely poly (lactic-co-glycolic acid) (PLGA), was studied. High-power sonication was integrated with dual asymmetric centrifugal (DAC) mixing to improve dispersion of nanoparticles during solvent casting...
June 14, 2018: Journal of Biomedical Materials Research. Part A
T Kh Tenchurin, S I Belousov, Yu I Kiryukhin, L P Istranov, E V Istranova, A D Shepelev, V G Mamagulashvili, R A Kamyshinsky, S N Chvalun
For efficient manufacturing of fibrous collagen-based materials by electrospinning, the search on optimal rheological parameters is of the great importance. Rheological characteristics and denaturation of collagen in aqueous dispersions were studied as a function of shear rate and acetic acid concentration in the range of 3-9% w/w at temperature from 20 to 40°C. It was shown that an increase in temperature, acetic acid concentration of the collagen dispersion leads to a significant decrease in its viscosity...
June 12, 2018: Journal of Biomedical Materials Research. Part A
Seyedali Seyedmajidi, Maryam Seyedmajidi, Ebrahim Zabihi, Karimollah Hajian-Tilaki
Considering to the possibility of cellular and genetic damage by the implant materials in the patient and the clinician, the safety of the biomaterials should be evaluated. The purpose of this study was to compare the cytotoxicity and genotoxicity induced by two nanocomposites, hydroxyapatite/bioactive glass (HA/BG) and fluorapatite/bioactive glass (FA/BG) in vitro. Biomaterial extracts (BMEX, 100%) were prepared by incubating 100 mg/mL of each biomaterial powder in complete culture medium (RPMI1640 + 10% FBS) for 72 hours...
June 12, 2018: Journal of Biomedical Materials Research. Part A
Thomas A Horbett
Fibrinogen (Fg) adsorption is an important mechanism underlying cell adhesion to biomaterials and was the major focus of the author's research career. This article summarizes our work on Fg adsorption, with citations of related work as appropriate. The molecular properties of Fg that promote adsorption and cell adhesion will be described. In addition, the adsorption behavior of Fg from buffer, binary solutions with other proteins, and blood plasma will be discussed, including the Vroman effect. Studies of platelet adhesion to surfaces preadsorbed with blood plasmas selectively deficient in Fg, vitronectin (Vn), fibronectin (Fn), or von Willebrand's factor (vWf) will be reviewed...
June 12, 2018: Journal of Biomedical Materials Research. Part A
Jelena Simonovic, Bosko Toljic, Nadja Nikolic, Jasna Vujin, Radmila Panajotovic, Rados Gajic, Elena Bekyarova, Amelia Cataldi, Vladimir Parpura, Jelena Milasin
Stem cell-based therapies are considered a promising treatment modality for many medical conditions. Several types of stem cells with variable differentiation potentials have been isolated from dental tissues, among them stem cells from apical papilla (SCAP). In parallel, new classes of biocompatible nanomaterials have also been developed, including graphene and carbon nanotube-based materials. The aim of the study was to assess whether graphene dispersion (GD) and water-soluble single walled carbon nanotubes (ws-SWCNT), may enhance SCAPs capacity to undergo neural differentiation...
June 12, 2018: Journal of Biomedical Materials Research. Part A
Michael Wöltje, Melanie Böbel, Michaela Bienert, Sabine Neuss, Dilibaier Aibibu, Chokri Cherif
Growth factors play a crucial role in wound healing in general and are promising tools for the treatment of chronic wounds as they can restore the physiological wound healing process. In growth factor-loaded wound dressings, human epidermal growth factor (EGF) is released in a burst and washed out quickly. The developed matrix consists of recombinant EGF produced in transgenic silkworms as a fusion protein with the fibroin light chain. The covalent linkage prevents EGF from draining into the surrounding tissue while presenting the growth factor on the surface...
May 23, 2018: Journal of Biomedical Materials Research. Part A
Donglin Gan, Min Liu, Tong Xu, Kefeng Wang, Hui Tan, Xiong Lu
The BMP-2 encapsulated BNPs are prepared by a desolvation method, and are further coated by chitosan (CHI) coatings to obtain positively charged NPs (CBNPs). Va The BMP-2 encapsulated BNPs are prepared by a desolvation method, and are further coated by chitosan (CHI) coatings to obtain positively charged NPs (CBNPs) Advancements in bone tissue engineering require the improvement of tissue scaffolds, which should not only exhibit suitable mechanical properties and highly porous structures, but also effectively carry signaling molecules that can mediate bone formation and tissue regeneration...
May 23, 2018: Journal of Biomedical Materials Research. Part A
Wen Chen, Li Xiao, Jian Bai, Wen Zeng, Mingcan Yang, Bingyi Shi, Chuhong Zhu
The mobilization and homing of endothelial progenitor cells (EPCs) contribute to the rapid endothelialization of tissue engineering blood vessel (TEBV). Inflammation can affect TEBV patency, and monocytes/macrophages (MM) are the main effector cells. But it is not clear how EPCs interact with MM after TEBV transplantation. Our results showed acellular materials would not directly cause acute and severe inflammatory responses but activate E-selectin expression in homing EPCs, gradually promoting the polarization of MM to the M1...
May 23, 2018: Journal of Biomedical Materials Research. Part A
Gulsan Ara Sathi Kazi, Kazi Anisur Rahman, Mahmoud Farahat, Takuya Matsumoto
The hydrogel is considering as functional substrates for three-dimensional (3D) environment mimicking the native tissue in vitro. To get the cell or tissue culture result in different stiffness, researchers are used separate gel at the different time. Sometimes these results are manipulated by surrounding environment. To overcome this, we prepared a single hydrogel with different young modulus using a 3D printed mold and cell culture and tissue culture was performed to check the functional capacity. In this proposed device we successfully produced a multi properties agarose hydrogel on a single platform...
May 20, 2018: Journal of Biomedical Materials Research. Part A
Hongxuan Quan, Yongjoon Kim, Hee Chul Park, Hyeong-Cheol Yang
Placement of dental implants initiates inflammatory foreign body response, in which macrophages play a central role and affect the subsequent tissue healing process such as bone formation. The purpose of this study was to fabricate phosphatidylserine (PS)-containing supported lipid bilayers (SLBs) on a titanium surface to regulate the polarization of macrophages, a critical factor that affects following tissue healing and regeneration. The fluorescent recovery after photobleaching (FRAP) images showed that the percentage of PS had a critical influence on the fluidity, and 20% PS had the highest fluidity...
May 20, 2018: Journal of Biomedical Materials Research. Part A
Xiang Lu, Kai Li, Youtao Xie, Shengcai Qi, Qingyi Shen, Jiangming Yu, Liping Huang, Xuebin Zheng
Osteoimmunology has revealed the importance of a favorable immune response for successful biomaterial-mediated osteogenesis. Boron-incorporated calcium silicate (Ca11 Si4 B2 O22 , B-CS) coating has been reported as a potential candidate for improving osteogenesis in orthopedic applications in vitro. However, relatively little is known about its effects on the immune response and subsequent osteogenesis. In this work, the immunomodulatory properties of the B-CS coating and its specific mechanism of action were explored...
May 20, 2018: Journal of Biomedical Materials Research. Part A
Silvia M Becerra-Bayona, Viviana R Guiza-Arguello, Brooke Russell, Magnus Höök, Mariah S Hahn
Collagen I interactions with integrins α1 and α2 are known to support human mesenchymal stem cell (hMSC) osteogenesis. Nonetheless, elucidating the relative impact of specific integrin interactions has proven challenging, in part due to the complexity of native collagen. In the present work, we employed two collagen-mimetic proteins - Scl2-2 and Scl2-3 - to compare the osteogenic effects of integrin α1 versus α2 signaling. Scl2-2 and Scl2-3 were both derived from Scl2-1, a triple helical protein lacking known cell adhesion, cytokine binding, and matrix metalloproteinase sites...
May 15, 2018: Journal of Biomedical Materials Research. Part A
Kai Wang, Rajendra Narayan Mitra, Min Zheng, Zongchao Han
The major purpose of this article is to evaluate oligochitosan coated cerium oxide nanoparticles (OCCNPs) alginate laden injectable hydrogels and their potential treatment for age-related macular degeneration (AMD). The water soluble OCCNPs were loaded within injectable hydrogels as antioxidative agents. The release of OCCNPs from hydrogel, radical scavenging properties, and biocompatibility were evaluated and calculated in vitro. The effects of OCCNP laden hydrogel downregulating expression of angiogenic proteins and pro-inflammatory cytokines were quantified in human retinal pigment epithlium-19 (ARPE-19) and umbilical endothelium cell lines...
May 12, 2018: Journal of Biomedical Materials Research. Part A
Oliwia Jeznach, Dorota Kołbuk, Paweł Sajkiewicz
Cartilage loss due to age-related degeneration and mechanical trauma is a significant and challenging problem in the field of surgical medicine. Unfortunately, cartilage tissue can be characterized by the lack of regenerative ability. Limitations of conventional treatment strategies, such as auto-, allo- and xenografts or implants stimulate an increasing interest in the tissue engineering approach to cartilage repair. This review discusses the application of polymer-based scaffolds, with an emphasis on hydrogels in cartilage tissue engineering...
May 4, 2018: Journal of Biomedical Materials Research. Part A
Mohamed Ibrahim, Julia Schoelermann, Kamal Mustafa, Mihaela R Cimpan
Human exposure to titanium dioxide nanoparticles (nano-TiO2 ) is increasing. An internal source of nano-TiO2 is represented by titanium-based orthopedic and dental implants can release nanoparticles (NPs) upon abrasion. Little is known about how the size of NPs influences their interaction with cytoskeletal protein networks and the functional/homeostatic consequences that might follow at the implant-bone interface with regard to osteoblasts. We investigated the effects of size of anatase nano-TiO2 on SaOS-2 human osteoblast-like cells exposed to clinically relevant concentrations (0...
April 30, 2018: Journal of Biomedical Materials Research. Part A
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