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Journal of Biomedical Materials Research. Part A

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https://www.readbyqxmd.com/read/29143479/encapsulation-of-rifampin-in-a-polymeric-layer-by-layer-structure-for-drug-delivery
#1
Akbar Esmaeili, Meissam Khodaei
Rifampin (RIF) is a bactericidal antibiotic drug and potent inducer of hepatic and intestinal cytochrome P-450 (CYP-450) enzyme systems. Given by mouth or intravenously, it can cause numerous clinical drug interactions; thus, alternative systems of drug delivery that bypass some or all of its toxic effects are well worth investigating. In this study, a controlled layer-by-layer (LBL) process of encapsulating RIF in biocompatible alginate and chitosan polymers loaded onto Fe3 O4 nanoparticles was developed. Fe3 O4 nanoparticles were synthesized from FeCl3 ·6H2 O using a hydrothermal procedure...
November 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29143459/the-spatial-patterning-of-rgd-and-bmp-2-mimetic-peptides-at-the-subcellular-scale-modulates-human-mesenchymal-stem-cells-osteogenesis
#2
I Bilem, L Plawinski, P Chevallier, C Ayela, E D Sone, G Laroche, M C Durrieu
Engineering artificial extracellular matrices (ECMs), based on the biomimicry of the spatial distribution of proteins and growth factors within their native microenvironment, is of great importance for understanding mechanisms of bone tissue regeneration. Herein, photolithography is used to decorate glass surfaces with subcellular patterns of RGD and BMP-2 ligands; two mimetic peptides recognized to be involved in stem cells osteogenesis. The biological relevance of well-defined RGD and BMP-2 patterned surfaces is evaluated by investigating the differentiation of human mesenchymal stem cells (hMSCs) into osteoblasts, in the absence of induction media...
November 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29143449/osteoinductivity-of-nanostructured-hydroxyapatite-functionalized-gelatin-modulated-by-human-and-endogenous-mesenchymal-stromal-cells
#3
E Della Bella, A Parrilli, A Bigi, S Panzavolta, S Amadori, G Giavaresi, L Martini, V Borsari, M Fini
The demand of new strategies for the induction of bone regeneration is continuously increasing. Biomimetic porous gelatin-nanocrystalline hydroxyapatite scaffolds with tailored properties were previously developed, showing a positive response in terms of cell adhesion, proliferation, and differentiation. In the present paper, we focused on their osteoinductive properties. The effect of scaffolds on osteogenic differentiation of human mesenchymal stromal cells (hMSCs) was investigated in vitro. hMSCs were seeded on GEL (type A gelatin) and GEL containing 10wt% hydroxyapatite (GEL-HA) and cultured in osteogenic medium...
November 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29143443/multiscale-characterisation-of-cortical-bone-composition-microstructure-and-nanomechanical-properties-in-experimentally-induced-osteoporosis
#4
Furqan A Shah, Adrian Stoica, Carina Cardemil, Anders Palmquist
Cortical bone plays a vital role in determining overall bone strength. We investigate the structural, compositional, and nanomechanical properties of cortical bone following ovariectomy (OVX) of 12 week old Sprague Dawley rats, since this animal model is frequently employed to evaluate the performance of implantable biomaterials in compromised bone healing conditions. Morphological parameters and material properties of bone in the geometrical centre of the femoral cortex were investigated four and eight weeks post-OVX and in unoperated controls (Ctrl), using X-ray micro-computed tomography, backscattered electron scanning electron microscopy, Raman spectroscopy, and nanoindentation...
November 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29143442/development-of-biomimetic-thermoplastic-polyurethane-fibroin-small-diameter-vascular-grafts-via-a-novel-electrospinning-approach
#5
Emily Yu, Hao-Yang Mi, Jue Zhang, James A Thomson, Lih-Sheng Turng
A new electrospinning approach for fabricating vascular grafts with a layered, circumferentially aligned, and micro-wavy fibrous structure similar to natural elastic tissues has been developed. The customized electrospinning collector was able to generate wavy fibers using the dynamic "jump rope" collecting process, which also solved the sample removal problem for mandrel-type collectors. In this study, natural silk fibroin and synthetic thermoplastic polyurethane (TPU) were combined at different weight ratios to produce hybrid small-diameter vascular grafts...
November 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29139224/a-polyelectrolyte-multilayer-platform-for-investigating-growth-factor-delivery-modes-in-human-liver-cultures
#6
Christine Lin, Raimundo Romero, Lioudmila V Sorokina, Kimberly R Ballinger, Laura W Place, Matt J Kipper, Salman R Khetani
Polyelectrolyte multilayers (PEMs) of chitosan and heparin are useful for mimicking growth factor (GF) binding to extracellular matrix (ECM) as in vivo. Here, we developed a PEM platform for delivering bound/adsorbed GFs to monocultures of primary human hepatocytes (PHHs) and PHH/non-parenchymal cell (NPC) co-cultures, which are useful for drug development and regenerative medicine. The effects of ECM protein coating (collagen I, fibronectin, and Matrigel®) and terminal PEM layer on PHH attachment/functions were determined...
November 15, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29119674/assessment-of-hydrogels-for-bioprinting-of-endothelial-cells
#7
Leo Benning, Ludwig Gutzweiler, Kevin Tröndle, Julian Riba, Roland Zengerle, Peter Koltay, Stefan Zimmermann, G Björn Stark, Günter Finkenzeller
In tissue engineering applications, vascularization can be accomplished by co-implantation of tissue forming cells and endothelial cells (ECs), whereby the latter are able to form functional blood vessels. The use of three-dimensional (3D) bioprinting technologies has the potential to improve the classical tissue engineering approach because these will allow the generation of scaffolds with high spatial control of endothelial cell allocation. This study focuses on a side by side comparisons of popular commercially available bioprinting hydrogels (matrigel, fibrin, collagen, gelatin, agarose, Pluronic F-127, alginate and alginate/gelatin) in the context of their physicochemical parameters, their swelling/degradation characteristics, their biological effects on vasculogenesis-related EC parameters and their printability...
November 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29115031/biomimetic-multidirectional-scaffolds-for-zonal-osteochondral-tissue-engineering-via-a-lyophilization-bonding-approach-1
#8
Drew Clearfield, Andrew Nguyen, Mei Wei
The zonal organization of osteochondral tissue underlies its long term function. Despite this, tissue engineering strategies targeted for osteochondral repair commonly rely on the use of isotropic biomaterials for tissue reconstruction. There exists a need for a new class of highly biomimetic, anisotropic scaffolds that may allow for the engineering of new tissue with zonal properties. To address this need, we report the facile production of monolithic multidirectional collagen-based scaffolds that recapitulate the zonal structure and composition of osteochondral tissue...
November 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29115001/the-synergistic-effect-of-bone-forming-peptide-1-and-endothelial-progenitor-cells-to-promote-vascularization-of-tissue-engineered-bone
#9
Huaixi Wang, Hao Cheng, Xiangyu Tang, Jingyuan Chen, Jun Zhang, Wei Wang, Wenkai Li, Guanlin Lin, Hua Wu, Chaoxu Liu
Large segmental bone defect repair remains a challenge in orthopedic surgeries. The tissue engineered bone graft will be a promising approach if vascularization of the graft is realized. In this study, beta-tricalcium phosphate (β-TCP) scaffold incorporated with bone forming peptide-1 (BFP-1) was fabricated. Endothelial progenitor cells (EPCs) were introduced as well. We investigated the effect of BFP-1 on the proliferation, differentiation and angiogenic functions of EPCs. Additionally, segmental femur bone defect was created in rabbits...
November 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29106040/the-effect-of-temporal-manipulation-of-tgf%C3%AE-3-and-fgf2-on-the-derivation-of-proliferative-chondrocytes-from-mensenchymal-stem-cells-a-study-monitored-by-qrt-pcr-and-molecular-beacon-based-nanosensors
#10
Li Min Tay, Christian Wiraja, Yingnan Wu, Zheng Yang, Eng Hin Lee, Chenjie Xu
Proliferative chondrocytes are critical to realize regeneration of damaged epiphyseal growth plate. However, acquiring autologous replacement cells involves highly-invasive procedures and often results in limited cell quantity. Mesenchymal stem cells (MSCs) are a potential source of chondrogenic cells for the treatment of cartilage disorders and injuries. The temporal effect of transforming growth factor beta 3 (TGFβ3) and fibroblast growth factor 2 (FGF2) on the derivation of proliferative chondrocytes from MSCs in 3D agarose was investigated by manipulating the duration of TGFβ3 and FGF2 treatment...
November 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29105999/fabrication-of-interconnected-porous-%C3%AE-tricalcium-phosphate-%C3%AE-tcp-based-on-a-setting-reaction-of-%C3%AE-tcp-granules-with-hno3-followed-by-heat-treatment
#11
Kunio Ishikawa, Tansza Setiana Putri, Akira Tsuchiya, Keisuke Tanaka, Kanji Tsuru
β-Tricalcium phosphate [β-TCP] is the typical bone substitute due to its excellent osteoconductivity and bioresorbability. One of the keys to improve its potential as bone substitute is to introduce porous structure and its regulation. In this study, interconnected porous β-TCP blocks were fabricated through a setting reaction of β-TCP granules and subsequent heat treatment. First, β-TCP granules were mixed with HNO3 . Upon mixing, β-TCP granules were bridged with dicalcium phosphate dihydrate [DCPD: CaHPO4 ·2H2 O] containing Ca(NO3 )2 ...
November 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29105979/biocompatibility-and-immunogenicity-of-elastin-like-recombinamer-biomaterials-in-mouse-models
#12
K Changi, B Bosnjak, C Gonzalez-Obeso, R Kluger, J C Rodríguez-Cabello, O Hoffmann, M M Epstein
Novel thermo-sensitive elastin-like recombinamers (ELRs) containing bioactive molecules were created for use as a biomimetic biomaterial for tissue regeneration. For effective use for in vivo applications, it is essential to ensure that they do not induce adverse inflammatory, immune, or allergic responses that inhibit tissue repair. Therefore, we sought to establish a pre-clinical approach to evaluate biocompatibility in experimental mice using ELRs as a prototype biomaterial. Firstly, we measured in vitro proliferation and cytokine production from BALB/c and C57BL/6 mouse splenocytes incubated with ELRs...
November 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29105943/characterization-of-printed-pla-scaffolds-for-bone-tissue-engineering
#13
Agathe Grémare, Vera Guduric, Reine Bareille, Valérie Heroguez, Simon Latour, Nicolas L'Heureux, Jean-Christophe Fricain, Sylvain Catros, Damien Le Nihouannen
Autografts remain the gold standard for orthopedic transplantations. However, to overcome its limitations, bone tissue engineering proposes new strategies. This includes the development of new biomaterials such as synthetic polymers, to serve as scaffold for tissue production. The objective of this present study was to produce poly(lactic) acid (PLA) scaffolds of different pore size using fused deposition modeling (FDM) technique and to evaluate their physicochemical and biological properties. Structural, chemical, mechanical and biological characterizations were performed...
November 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29094503/absorbable-mineral-nanocomposite-for-biomedical-applications-influence-of-homogenous-fiber-dispersity-on-mechanical-properties
#14
Elias Mulky, Katharina Maniura-Weber, Martin Frenz, Giuseppino Fortunato, Reto Luginbuehl
Electrospun micro- and nano-sized fibers are frequently used as reinforcing elements in low temperature ceramic composites for biomedical applications. Electrospinning of fibers yield, however, not individual fibers, but rather fiber-mats that are difficult to separate. Most investigations have been performed on diced mats and highly non-homogenous composites. We examined the influence of dispersed electrospun single micro- and nano-meter fibers on the mechanical properties of calcium phosphate cement composites...
November 1, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29094483/impact-of-intraoperative-blood-salvage-on-monocyte-subsets-alteration-and-intracellular-tnf-%C3%AE-production
#15
Hagen Bomberg, Thomas Volk, Andreas Biedler, Sven O Schneider
Intraoperative salvaged blood is used to reduce allogeneic blood transfusion in orthopedic surgery patients. However, salvaged blood reinfusion may lead to immune reactions. Salvaged and venous blood from 20 patients undergoing hip arthroplasty was processed. The salvaged samples were mixed with patients' venous blood and incubated in absence or presence of lipopolysaccharide. SAMPLES: Venous: venous patient blood (n=20). Native: mixed salvaged native blood (n=20). Filtered: mixed salvaged leukocyte filtered blood (n=20)...
November 1, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29094469/afm-and-nanoindentation-investigation-of-pdms-elastomeric-substrate-compliancy-for-various-sputtered-thin-film-morphologies
#16
Debashis Maji, Soumen Das
Crack free electrically continuous metal thin films over soft elastomeric substrates play an integral part in realization of modern day flexible bio-electronics and biosensors. Under non-optimized deposition conditions, delamination and/or cracking of the top film as well as the underlying soft substrate hinders optimal performance of these devices. Hence it is very important to understand and control not only the various deposition factors like power, time or deposition pressure but also investigate the various interfacial physics playing a critical role in assuring thin film adhesion and substrate compliancy...
November 1, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29094460/hydrogel-fiber-conductive-scaffold-for-bone-tissue-engineering
#17
Sajedeh Khorshidi, Akbar Karkhaneh
Hydrogel/fiber composites have emerged as compelling scaffolds for regeneration purposes. Any bio-related modification or feature may endow more regenerative functionality to these composites. In the present study, a hydrogel/fiber scaffold possessing electrical conductivity in both phases, hydrogel and fiber, has been prepared and evaluated. Fiber component possessed electrical conductivity due to the presence of polyaniline (PANi) and hydrogel fraction thanks to the presence of graphene nanoparticles. PANi based fibers were processed via electrospinning and transformed into a three-dimensional structure through ultrasonication...
November 1, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29067792/enhanced-hepatogenic-differentiation-of-bone-marrow-derived-mesenchymal-stem-cells-on-liver-ecm-hydrogel
#18
Bo Wang, Wuwei Li, Derrick Dean, Manoj K Mishra, Kennedy S Wekesa
BM-MSC is a promising alternative cell source to primary hepatocytes because of their ability to differentiate into hepatocyte-like cells. However, their inability to differentiate efficiently and potential to turn into myofibroblasts restrict their applications. This study developed a plate coating from the liver extracellular matrix (ECM) and investigated its ability in facilitating the BM-MSCs proliferation, hepatic differentiation, and hepatocyte-specific functions during in vitro culture. After 28-day culture, BM-MSCs on the ECM coating showed hepatocyte-like morphology, and certain cells took up LDL...
October 25, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29067777/surface-modification-of-bulk-titanium-substrates-for-biomedical-applications-via-low-temperature-microwave-hydrothermal-oxidation
#19
Alice Cheng, W Brandon Goodwin, Ben M deGlee, Rolando A Gittens, Jonathan P Vernon, Sharon L Hyzy, Zvi Schwartz, Kenneth H Sandhage, Barbara D Boyan
Micro-to-nanoscale surface topographies of orthopaedic and dental implants can affect fluid wetting and biological response. Nanoscale features can be superimposed on microscale roughness of titanium (Ti) surfaces at high temperatures, resulting in increased osteoblast differentiation. However, high temperatures can compromise mechanical properties of the bulk material. Here, we have developed a novel low-temperature microwave hydrothermal (MWHT) oxidation process for nanomodification of microrough (SLA) Ti surfaces...
October 25, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29067774/recellularization-of-well-preserved-decellularized-kidney-scaffold-using-adipose-tissue-derived-stem-cells
#20
Aibing Xue, Guangzhu Niu, Yuan Chen, Kailin Li, Zhiying Xiao, Yun Luan, Chao Sun, Xiaoshuai Xie, Denglu Zhang, Xiaohang Du, Feng Kong, Yanxia Guo, Haiyang Zhang, Guanghui Cheng, Qian Xin, Yong Guan, Shengtian Zhao
To establish a recellularization kidney model by using adipose tissue-derived stem cells (ADSCs) as seeding cells and to investigate the growth and differentiation of ADSCs in decellularized kidney scaffolds. ADSCs were isolated using a modified method and then identified using flow cytometry analysis. Osteogenesis and adipogenesis differentiation were performed. Rat kidneys were decellularized using 0.5% sodium dodecyl sulfate (SDS). Immunofluorescence, immunohistochemisry and scanning electron microscope were conducted to examine the scaffold microstructure...
October 25, 2017: Journal of Biomedical Materials Research. Part A
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