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Journal of Biomedical Materials Research. Part A

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https://www.readbyqxmd.com/read/28804998/peripheral-nerve-growth-within-a-hydrogel-microchannel-scaffold-supported-by-a-kink-resistant-conduit
#1
Dena Shahriari, Masataka Shibayama, Daniel Lynam, Kayla Wolf, Go Kubota, Jacob Koffler, Mark Tuszynski, Wendy Campana, Jeff Sakamoto
Nerve repair in several mm-long nerve gaps often requires an interventional technology. Microchannel scaffolds have proven effective for bridging nerve gaps and guiding axons in the peripheral nervous system (PNS). Nonetheless, fabricating microchannel scaffolds at this length scale remains a challenge and/or is time consuming and cumbersome. In this work, a simple computer-aided microdrilling technique was used to fabricate 10 mm-long agarose scaffolds consisting of 300 µm-microchannels and 85 µm-thick walls in less than an hour...
August 14, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28804996/in-vitro-evaluation-of-3d-bioprinted-tri-polymer-network-scaffolds-for-bone-tissue-regeneration
#2
Stephanie T Bendtsen, Mei Wei
In vitro evaluations provide vital information on the ability of tissue engineered scaffolds to support cell life and promote natural physiological behaviors in culture. Such assessments are necessary to conduct before implementation of the scaffolds for tissue healing in vivo. The scaffold extracellular matrix must provide the biochemical and mechanical cues necessary to promote cellular attachment, migration and proliferation before differentiation and new tissue deposition can occur. In this study, an in vitro evaluation was conducted to assess the ability of scaffolds 3D printed with a previously developed alginate-polyvinyl alcohol-hydroxyapatite formulation to promote proliferation of encapsulated MC3T3 cells...
August 14, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28804994/neutron-activatable-needles-for-radionuclide-therapy-of-solid-tumors
#3
Junghyun Kim, Roger J Narayan, Xiuling Lu, Michael Jay
Various approaches have been undertaken to enhance the delivery of therapeutic agents, including tissue-killing radionuclides, into solid tumors. Here we describe the preparation of conical needles composed of Ti and Mo coated by pulsed laser deposition or chemical vapor deposition with elements (Ho and Re) that can readily yield radioactive isotopes following irradiation in a neutron flux. The radioactive needles, whose design were based on solid microneedle arrays used in transdermal drug delivery, can be produced with minimal handling of radioactivity and subsequently inserted into tumors as a means of internal radiation therapy...
August 14, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28795783/low-density-polyethylene-functionalized-with-antibiofilm-compounds-inhibits-escherichia-coli-cell-adhesion
#4
Silvia Dell'Orto, Cristina Cattò, Federica Villa, Fabio Forlani, Espedito Vassallo, Marco Morra, Francesca Cappitelli, Stefania Villa, Arianna Gelain
The present work concerns an efficient strategy to obtain novel medical devices materials able to inhibit biofilm formation. The new materials were achieved by covalent grafting of p-aminocinnamic or p-aminosalicylic acids on low density polyethylene coupons. The polyethylene surface, previously activated by oxygen plasma treatment, was functionalized using 2-hydroxymethylmetacrylate as linker. The latter was reacted with succinic anhydride affording the carboxylic end useful for the immobilization of the antibiofilm molecules...
August 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28795779/core-shell-fibrous-scaffold-as-a-vehicle-for-sustained-release-of-retinal-pigmented-epithelium-derived-factor-pedf-for-photoreceptor-differentiation-of-conjunctiva-mesenchymal-stem-cells
#5
Fatemeh Nasehi, Mohsen Karshenas, Samad Nadri, Ghasem Barati, Ahdiye Salim
Coaxial electrospinning technique was introduced as a flexible and promising technique for the fabrication of core-shell fibrous scaffold from poly ethylene glycol/poly caprolactone (PEG/PCL), where retinal pigmented epithelium-derived factor (PEDF) was encapsulated in the core, for photoreceptor differentiation of conjunctiva mesenchymal stem cells (CJMSCs) seed on scaffolds. The morphology and structure of fibers were characterized using SEM and TEM and photoreceptor differentiation was examined by quantitative real time PCR (qPCR)...
August 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28795778/time-dependent-effect-of-electrical-stimulation-on-osteogenic-differentiation-of-bone-mesenchymal-stromal-cells-cultured-on-conductive-nanofibers
#6
Siqi Zhu, Wei Jing, Xiaoqing Hu, Zirong Huang, Qing Cai, Yingfang Ao, Xiaoping Yang
Bone tissue engineering using bone mesenchymal stromal cells (BMSCs) is a multidisciplinary strategy that requires biodegradable scaffold, cell, various promoting cues to work simultaneously. Electrical stimulation (ES) is known able to promote osteogenic differentiation of BMSCs, but it is interesting to know how can it play the strongest promotion effect. To strengthen local ES on BMSCs, parallel-aligned conductive nanofibers were electrospun from the mixtures of poly(L-lactide) (PLLA) and multi-walled carbon nanotubes (MWCNTs), and used for cell culture...
August 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782282/the-effect-of-amino-plasma-enhanced-chemical-vapor-deposition-treated-titanium-surface-on-schwann-cells
#7
Jinghui Zhao, Yu Guo, Lan A, Wenjing Luo, Xiaona Wang, Li Fu, Qing Cai, Yanmin Zhou
The surface modification of titanium and its alloys with amino group plasma-enhanced chemical vapor deposition has been proven to enhance the performance of implants on initial osteoblast bioactivity in vitro. However, scarce information on the effect of this kind of surface modification on nerve regeneration exists. In this study, the surface chemistry of pure Ti disks and surface-modified disks was examined using X-ray photoelectron spectroscopy. Cell counting kit 8 assay, 4,6-diamidino-2-phenylindole staining, flow cytometry, and scanning electron microscopy showed that either the p30% or cw+p30% mode-mediated surface significantly promote Schwann cell adhesion without any cytotoxicity compared with the pure Ti surface, and the cw+p30% group showed the best performance on cell adhesion...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782280/orthopaedic-wear-particle-induced-bone-loss-and-exogenous-macrophage-infiltration-is-mitigated-by-local-infusion-of-nf-%C3%AE%C2%BAb-decoy-oligodeoxynucleotide
#8
Tzuhua Lin, Jukka Pajarinen, Akira Nabeshima, Luis A Córdova, Florence Loi, Emmanuel Gibon, Laura Lu, Karthik Nathan, Eemeli Jämsen, Zhenyu Yao, Stuart B Goodman
Excessive production of wear particles from total joint replacements (TJRs) induces chronic inflammation, macrophage infiltration, and consequent bone loss (periprosthetic osteolysis). This inflammation and bone remodeling are critically regulated by the transcription factor NF-κB. We previously demonstrated that inhibition of NF-κB signaling by using the decoy oligodeoxynucleotide (ODN) mitigates polyethylene wear particle-induced bone loss using in vitro and in vivo models. However, the mechanisms of NF-κB decoy ODN action, and in particular its impact on systemic macrophage recruitment, remain unknown...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782272/structure-dissolution-behavior-cytocompatibility-and-antibacterial-activity-of-silver-containing-calcium-phosphate-invert-glasses
#9
Sungho Lee, Takayoshi Nakano, Toshihiro Kasuga
Novel CaO-P2 O5 -Nb2 O5 -Ag2 O invert glasses with substitution Ag2 O for Nb2 O5 were successfully prepared using a melt-quenching method. Ag2 O in the glasses act as a network modifier oxide, playing the same role as Na2 O, which breaks the phosphate chains. Analysis of the ultraviolet-visible absorption spectra of the glasses showed that the glass matrix contained ionic silver species and silver nanoparticles. Approximately 0.05 mM of Nb(5+) ions released from the glasses, which would be expected to stimulate osteoblast differentiation...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782254/in-vitro-study-of-central-nervous-system-foreign-body-response-towards-hydrogel-particle-modified-planar-substrate
#10
Emily A Morin, Wei He
Central nervous system (CNS) neural device functionality hinges on effective communication with surrounding neurons. This depends on both the permissiveness of the device material to promote neuron integration and the ability of the device to avoid a chronic inflammatory response. Previously our lab developed a method using surface adsorbed hydrogel particles (HPs) to promote neuron integration onto typically non-neural-permissive substrates. However, little information is known regarding CNS inflammatory cell type responses toward the modified HP surface...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782253/alkaline-poly-ethylene-glycol-based-hydrogels-for-a-potential-use-as-bioactive-wound-dressings
#11
Julia Koehler, Leonie Wallmeyer, Sarah Hedtrich, Ferdinand P Brandl, Achim M Goepferich
The number of patients with chronic wounds is increasing constantly in today's aging society. However, little work is done so far tackling the associated disadvantageous shift of the wound pH. In our study, we developed two different approaches on pH-modulating wound dressing materials, namely bioactive interpenetrating polymer network hydrogels based on poly(ethylene glycol) diacrylate/N-vinylimidazole/alginate (named VIx ) and poly(ethylene glycol) diacrylate/2-dimethylaminoethyl methacrylate/N-carboxyethylchitosan (named DMAEMAx )...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782240/electrophoretic-deposition-of-mgo-nanoparticles-imparts-antibacterial-properties-to-poly-l-lactic-acid-for-orthopedic-applications
#12
Daniel J Hickey, Divya Muthusamy, Thomas J Webster
Bacterial infection of implanted biomaterials is a serious problem that increases health care costs and negatively affects a considerable fraction of orthopedic procedures. In this field, magnesium oxide nanoparticles (MgO NPs) have emerged as a promising material to combat bacterial infection while maintaining or improving bone cell functions. Here, MgO NPs were electrophoretically deposited onto poly-L-lactic acid (PLLA) sheets to achieve a coating of highly exposed MgO NPs that directly influenced cell-substrate interactions at short time scales...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782236/porous-titanium-scaffolds-with-self-assembled-micro-nano-hierarchical-structure-for-dual-functions-of-bone-regeneration-and-anti-infection
#13
Lu Han, Menghao Wang, Honglong Sun, Peifei Li, Kefeng Wang, Fuzeng Ren, Xiong Lu
Porous titanium (Ti) scaffolds are widely used for bone repair because of their good biocompatibility, mechanical properties and corrosion resistance. However, pristine Ti scaffolds are bioinert and unable to induce bone regeneration. In this study, chitosan coated BSA nanoparticles (CBSA NPs) and oxidized alginate (OSA) were in a layer-by-layer (LbL) manner on Ti scaffolds. The LbL film possessed micro/nano hierarchical architectures, has the features of nanostructures, and possesses abundant functional groups from CBSA NPs and OSA to improve the surface biocompatibility and biofunctionality of Ti scaffolds...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782192/the-effect-of-four-types-of-artificial-nerve-graft-structures-on-the-repair-of-10-mm-rat-sciatic-nerve-gap
#14
Chan Zhou, Bin Liu, Yong Huang, Xiu Zeng, Huajian You, Jin Li, Yaoguang Zhang
Investigating the effect of four types of artificial nerve graft (ANG) structures on rat sciatic nerve defect repair will aid future ANG designs. In this study, fibroin fibres and polylactic acid were used to prepare four ANGs with differing structures: nerve conduit with micron-sized pores (Conduit with pore group), nerve conduit without micron-sized pores (Conduit group), nerve scaffold comprising Conduit with pore group material plus silk fibres (Scaffold with pore group), and nerve scaffold comprising Conduit group material plus silk fibres (Scaffold group)...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782183/pectin-nanocoating-reduces-proinflammatory-fibroblast-response-to-bacteria
#15
A Mieszkowska, J Folkert, T Gaber, K Miksch, K Gurzawska
Implant failures are primarily related to bacterial infections and inflammation. Nanocoating of implant devices with organic molecules is a method used for improving their integration into host tissues and limiting inflammation. Bioengineered plant-derived rhamnogalacturonan-Is (RG-Is) from pectins improve tissue regeneration and exhibit anti-inflammatory properties. Therefore, the aim of this study is to evaluate the in vitro effect of RG-I nanocoating on human gingival primary fibroblast (HGF) activity and proinflammatory response following Porphyromonas gingivalis (P...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782179/cytocompatibility-testing-of-hydrogels-towards-bioprinting-of-mesenchymal-stem-cells
#16
Leo Benning, Ludwig Gutzweiler, Kevin Tröndle, Julian Riba, Roland Zengerle, Peter Koltay, Stefan Zimmermann, G Björn Stark, Günter Finkenzeller
Mesenchymal stem cells (MSCs) represent a very attractive cell source for tissue engineering applications aiming at the generation of artificial bone substitutes. The use of three-dimensional (3D) bioprinting technologies has the potential to improve the classical tissue engineering approach because bioprinting will allow the generation of hydrogel scaffolds with high spatial control of MSC allocation within the bioprinted construct. In this study, we have performed direct comparisons between commercially available hydrogels in the context of their cytocompatibility towards MSCs and their physicochemical parameters with the aim to identify the most suitable hydrogel for drop-on-demand (DoD) printing of MSCs...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782178/staphylococcal-biofilm-gene-expression-on-biomaterials-a-methodological-study
#17
Annika Juhlin, Sara Svensson, Peter Thomsen, Margarita Trobos
The combination of increased healthcare access, universal aging, and infallible therapy demands, synergistically drive the need for the development of biomaterial technologies that mitigate the challenge of biomaterial-associated infections (BAI). Staphylococcus epidermidis and Staphylococcus aureus account for the majority of BAI due to their ability to accumulate in adherent multilayered biofilm. This investigation details the development of gene expression assays to evaluate the genetic processes of attachment, accumulation, maturation, and dispersal phases on biomaterials in vitro, while abiding by the Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782174/ccl2-ccl5-and-igf-1-participate-in-the-immunomodulation-of-osteogenesis-during-m1-m2-transition-in-vitro
#18
Luis A Córdova, Florence Loi, Tzu-Hua Lin, Emmanuel Gibon, Jukka Pajarinen, Akira Nabeshima, Laura Lu, Zhenyu Yao, Stuart B Goodman
The modulation of macrophage phenotype from pro-inflammatory (M1) to tissue healing (M2) via exogenous addition of interleukin-4 (IL-4) facilitates osteogenesis; however, the molecular mediators underlying this phenomenon remain unknown. This study characterizes the IL-4-dependent paracrine crosstalk between macrophages and osteoprogenitors and its effect on osteogenesis in vitro. Primary murine M1 were co-cultured with MC3T3 cells (M1-MC3T3) in both transwell plates and direct co-cultures. To modulate M1 to M2, M1-MC3T3 were treated with IL-4 (20ng/mL) at day 3 after seeding (M1+IL-4-MC3T3)...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782170/short-and-long-gap-peripheral-nerve-repair-with-magnesium-metal-filaments
#19
Tracy M Hopkins, Kevin J Little, John J Vennemeyer, Jefferson L Triozzi, Michael T Turgeon, Alexander M Heilman, D Minteer, K Marra, David B Hom, Sarah K Pixley
A current clinical challenge is to replace autografts for repair of injury gaps in peripheral nerves, which can occur due to trauma or surgical interruption. Biodegradable metallic magnesium filaments, placed inside hollow nerve conduits, could support nerve repair by providing contact guidance support for axonal regeneration. This was tested by repairing sciatic nerves of adult rats with single magnesium filaments placed inside poly(caprolactone) nerve conduits. Controls were empty conduits, conduits containing titanium filaments and/or isografts from donor rats...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28779510/cytotoxicity-evaluation-of-unfunctionalized-multiwall-carbon-nanotubes-ultrahigh-molecular-weight-polyethylene-nanocomposites
#20
Narsimha Mamidi, Héctor Manuel Leija, Jose Manuel Diabb, Irasema Lopez Romo, Diana Hernandez, Javier Villela Castrejón, Oscar Martinez Romero, Enrique V Barrera, Alex Elias Zúñiga
The carbon nanotubes were chosen for this study since long, small to medium diameter, and unfunctionalized nanotubes are considered less favorable for non-toxic applications. The intent of the study is to expand the use of CNTs beyond current understood nontoxic means. Multiwall carbon nanotube/ultrahigh molecular weight polyethylene (MWCNT/UHMWPE) nanocomposites were prepared by reinforcing long chain UHMWPE with MWCNTs. These nanocomposites were prepared to study their cytotoxicity assessments with human fibroblast cell lines...
August 4, 2017: Journal of Biomedical Materials Research. Part A
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