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Journal of Biomedical Materials Research. Part A

In Ae Kim, Sang-Hoon Rhee
This paper describes a novel method for the preparation of a biodegradable non-woven poly(ε-caprolactone) fabric with a partially-embedded apatite surface designed for application as a scaffold material for bone tissue engineering. The non-woven poly(ε-caprolactone) fabric was generated by the electro-spinning technique and then apatite was coated in simulated body fluid after coating the PVA solution containing CaCl2 ·2H2 O. The apatite crystals were partially- or fully-embedded into the thermoplastic poly(ε-caprolactone) fibers by controlling the degree of poly(ε-caprolactone) fiber surface melting in a convection oven...
March 21, 2017: Journal of Biomedical Materials Research. Part A
Forouzan Mohamadi, Somayeh Ebrahimi-Barough, Mohammad Reza Nourani, Mohammad Ali Derakhshan, Vahabodin Goodarzi, Mohammad Sadegh Nazockdast, Mehdi Farokhi, Roksana Tajerian, Reza Faridi Majidi, Jafar Ai
In among of various methods, nerve tissue engineering (NTE) is one of the applicable methods to reconstruct damaged nerve tissues. Electrospinning technique and biomaterials are often considered to fabricate fibrous tissue engineered conduits which have great similarity to the extracellular matrix on fiber structure. Polymer blending is one of the most effective methods for production of new materials with outstanding features. In this research, conduit structures as main part of the peripheral nerve regeneration based on polymer blend nanocomposites PCL/Collagen/NBG (poly (ε-caprolactone)/Collagen/nano bioglass) were manufactured by electrospinning technique...
March 21, 2017: Journal of Biomedical Materials Research. Part A
Katarzyna Nawrotek, Tanguy Marqueste, Zofia Modrzejewska, Roman Zarzycki, Agnieszka Rusak, Patrick Decherchi
The present study was designed to provide an appropriate micro-environment for regenerating axotomized neurons and proliferating/migrating cells. Because of its intrinsic permissive properties, biocompatibility and biodegradability, we chose to evaluate the therapeutic effectiveness of a chitosan-based biopolymer. The biomaterial toxicity was measured through in vitro test based on fibroblast cell survival on thermogelling chitosan lactate hydrogel substrate and then polymer was implanted into a C2 hemisection of the rat spinal cord...
March 21, 2017: Journal of Biomedical Materials Research. Part A
D Gugutkov, F Awaja, K Belemezova, M Keremidarska, N Krasteva, S Kuyrkchiev, G GallegoFerrer, S Seker, A E Elcin, Y M Elcin, G Altankov
Novel hybrid, fibrinogen/polylactic acid (FBG/PLA) nanofibers with different configuration (random vs. aligned) and dimensionality (2D vs.3D environment) were used to control the overall behaviour and the osteogenic differentiation of human Adipose Derived Mesenchymal Stem Cells (ADMSCs). Aligned nanofibers in both the 2D and 3D configurations are proved to be favoured for osteo-differentiation. Morphologically we found that on randomly configured nanofibers, the cells developed a stellate-like morphology with multiple projections, however, time-lapse analysis showed significantly diminished cell movements...
March 11, 2017: Journal of Biomedical Materials Research. Part A
Parvaneh Naserzadeh, Fatemeh Ghanbary, Enayatollah Seydi, Alireza Ghasemi, Mohammad Taghi Joghataei, Khadijeh Ashtari, Mohsen Akbari
With the ever-increasing use of carbon nanotubes (CNTs) in health-related and engineering applications, the hazardous risks of this material have become a major concern. It is well-known that CNTs accumulate with cytotoxic and genotoxic levels within vital organs. It has also been shown that treating cell cultures with CNTs resulted in cell cycle arrest and increased apoptosis/necrosis. The goal of this pilot study is to perform a comprehensive comparative study on the toxicity of single-wall (SW) and multi-wall (MW) carbon nanotubes in rat skin cells...
March 10, 2017: Journal of Biomedical Materials Research. Part A
Gaurav Lalwani, Michael D'Agati, Anu Gopalan, Sunny C Patel, Yahfi Talukdar, Balaji Sitharaman
Expansion of mesenchymal stem cells (MSCs) and maintenance of their self-renewal capacity in vitro requires specialized robust cell culture systems. Conventional approaches using animal derived or artificial matrices and a cocktail of growth factors have limitations such as consistency, scalability, pathogenicity and loss of MSC phenotype. Herein, we report the use of all-carbon 3D single- and multiwalled carbon nanotube scaffolds (SWCNTs and MWCNTs) as artificial matrices for long-term maintenance and expansion of human MSCs...
March 10, 2017: Journal of Biomedical Materials Research. Part A
Jing-Kun Zhang, Run-Xuan Du, Lin Zhang, Ya-Nan Li, Ming-le Zhang, Shuo Zhao, Xiang-Hua Huang, Yan-Fang Xu
Acellular matrix materials have been widely used to repair various tissues and organs. According to the plastic principle, when a part of the body is lost, it should be replaced with a similar material. Therefore, the use of a homologous organ-specific acellular vaginal tissue in vagina reconstruction repair surgery may show good results. However, the acellular vagina matrix (AVM) form large vertebrates is difficult to isolate. In this study, we described a multi-step method to prepare porcine AVM and evaluated the efficacy of acellularization...
March 10, 2017: Journal of Biomedical Materials Research. Part A
G D Stynes, T R Gengenbach, G K Kiroff, W A Morrison, M A Kirkland
Thiol groups can undergo a large variety of chemical reactions and are used in solution phase to conjugate many bioactive molecules. Previous research on solid substrates with continuous phase glow discharge polymerisation of thiol-containing monomers may have been compromised by oxidation. Thiol surface functionalisation via glow discharge polymerisation has been reported as requiring pulsing. Herein, continuous phase glow discharge polymerisation of allyl mercaptan (2-propene-1-thiol) was used to generate significant densities of thiol groups on a mixed macrodiol polyurethane and tantalum...
March 10, 2017: Journal of Biomedical Materials Research. Part A
Angel Insua, Alberto Monje, Hom-Lay Wang, Richard J Miron
BACKGROUND: Despite the growing number of publications in the field of implant dentistry, there are limited studies to date investigating the biology and metabolism of bone healing around dental implants and their implications in peri-implant marginal bone loss. PURPOSE: The aim of this review article is to provide a thorough understanding of the biological events taking place during osseointegration and the subsequent early and late phases of bone remodeling around dental implants...
March 9, 2017: Journal of Biomedical Materials Research. Part A
Xianfeng Zhou, Nianli Zhang, Steven Mankoci, Nita Sahai
Following the success of silicate-based glasses as bioactive materials, silicates are believed to play important roles in promoting bone formation and have therefore been considered to provide a hydroxyapatite surface layer capable of binding to bone as well as potentially being a pro-osteoinductive factor. Natural silicate minerals and silicate-substituted hydroxyapatites are also being actively investigated as orthopaedic bone and dental biomaterials for application in tissue engineering. However, the mechanisms for the proposed roles of silicate in these materials have not been fully understood and are controversial...
March 9, 2017: Journal of Biomedical Materials Research. Part A
Felipe Eltit, Ali Assiri, Donald Garbuz, Clive Duncan, Bassam Masri, Nelson Greidanus, Robert Bell, Manju Sharma, Michael Cox, Rizhi Wang
Adverse local tissue reactions (ALTR) are the primary cause of failure of metal on metal (MoM) hip implants, and fewer but not negligible number cases of non-modular metal on polyethylene (MoP) implants. In this study we analyzed 17 cases of MoP ALTR, and equal number of MoM, by histological observation, cobalt and chromium concentration in serum and synovial fluid and cytokine analysis in ALTR tissues. ALTRs in MoP are highly necrotic, affecting larger areas than MoM ALTRs. Degenerative changes in blood vessels' wall were seen in all MoP ALTRs...
March 7, 2017: Journal of Biomedical Materials Research. Part A
M E Galarraga-Vinueza, B Passoni, C A M Benfatti, J Mesquita-Guimarães, B Henriques, R S Magini, M C Fredel, B V Meerbeek, W Teughels, J C M Souza
Bioactive glass is an attractive biomaterial that has shown excellent osteogenic and angiogenic effects for oral bone repairing procedures. However, anti-biofilm potential related to such biomaterial has not been completely validated, mainly against multi-species biofilms involved in early tissue infections. The aim of the present study was to evaluate the anti-biofilm effect of 58S bioactive glass embedding calcium bromide compounds at different concentrations. Bioactive glass containing 0, 5, or 10wt% CaBr2 was synthesized by alkali sol-gel method and then characterized by physco-chemical and scanning electron microscopy (SEM)...
March 6, 2017: Journal of Biomedical Materials Research. Part A
Ting Liu, Pindong Li, Honglin Jin, Qian Ding, Zhenwei Zou, Gang Peng
Nanotechnology provides a novel scope for cancer therapeutics. Nanoscale platforms could influence the survival, adhesion and migration of cancer cells through altering the tumor microenvironments. We report here the development of an anti-tumor material designed specifically for cancer therapy. We synthesized a 48-amino acid peptide RADA-KLA, which could self-assemble into nanostructures with antitumor activities. We tested the microstructure of RADA-KLA nanofiber scaffold using transmission electron microscopy (TEM) and accessed rheological properties of the material...
March 6, 2017: Journal of Biomedical Materials Research. Part A
Ricardo Londono, Jenna L Dziki, Eric Haljasmaa, Neill Turner, Cynthia Leifer, Stephen F Badylak
All biomaterials, including biologic scaffolds composed of extracellular matrix (ECM), elicit a host immune response when implanted. The type and intensity of this response depends in part upon the thoroughness of decellularization and removal of cell debris from the source tissue. Pro-inflammatory responses have been associated with negative downstream remodeling events including scar tissue formation, encapsulation, and seroma formation. The relative effects of specific cellular components upon the inflammatory response are not known...
March 6, 2017: Journal of Biomedical Materials Research. Part A
Ali A Salifu, Constantina Lekakou, Fatima Labeed
Tissue engineering of human foetal osteoblast (hFOB) cells was investigated on gelatin-hydroxyapatite (HA), crosslinked, electrospun oriented fibre scaffolds at the different hydroxyapatite concentrations of 0, 10, 20 and 25 wt% in the dry fibres and different fibre diameter, pore size and porosity of scaffolds. Rheological tests and proton NMR spectroscopy were conducted for all solutions used for electrospinning. It was found that 25 wt% HA-gelatin scaffolds electrospun at 20 kV led to the greatest cell attachment, cell proliferation and extracellular matrix (ECM) production while fibre orientation improved the mechanical properties, where crosslinked electrospun 25 wt% HA-gelatin fibre scaffolds yielded a Young's modulus in the range of 0...
March 6, 2017: Journal of Biomedical Materials Research. Part A
Gustavo A Rico-Llanos, Jose Becerra, Rick Visser
Bone morphogenetic protein-2 (BMP-2) is widely used in orthopedic surgery and bone tissue engineering because of its strong osteogenic activity. However, BMP-2 treatments have several drawbacks and many groups are actively exploring alternatives. Since BMP-6 has been demonstrated to be more osteoinductive, its use, either alone or together with other growth factors, might be an interesting option. In this work we have compared the osteogenic effect of BMP-2, BMP-6 or insulin-like growth factor-1 (IGF-1), either alone or in combination...
March 3, 2017: Journal of Biomedical Materials Research. Part A
L P Merlin Rajesh Lal, G K Suraishkumar, Prabha D Nair
Tissue engineering strategies for cartilage aim to restore the complex biomechanical and biochemical properties of the native cartilage. To mimic the in-vivo microenvironment, we developed a novel scaffold based on chitosan-agarose (CHAG scaffold) resembling the properties of native cartilage extracellular matrix that aids in-vitro cartilage formation. The CHAG scaffolds had pore size ranging from 75 µm to 300 µm and the degradation of 18% over 6 months in PBS. L929 cells and Human Wharton's Jelly Mesenchymal Stem Cells (HWJ-MSCs) attached well and grew in the CHAG scaffolds...
March 3, 2017: Journal of Biomedical Materials Research. Part A
Kuihua Zhang, Dianwu Huang, Zhiyong Yan, Chunyang Wang
Biomimicing topological structure of natural nerve tissue to direct axon growth and controlling sustained release of moderate neurotrophic factors are extremely propitious to the functional recovery of damaged nervous systems. In this study, the heparin/collagen encapsulating nerve growth factor (NGF) multilayers were coated onto the aligned poly-L-lactide (PLLA) nanofibrous scaffolds via a layer-by-layer (LbL) self-assembly technique to combine biomolecular signals and physical guidance cues for peripheral nerve regeneration...
March 3, 2017: Journal of Biomedical Materials Research. Part A
Mahdiyeh Aghajanpoor, Sameereh Hashemi-Najafabadi, Mohamadreza Baghaban-Eslaminejad, Fatemeh Bagheri, Seyyed Mohammad Mousavi, Foruogh Azam Sayyahpour
One of the major problems associated with the electrospun scaffolds is their small pore size, which limits the cellular infiltration for bone tissue engineering. In this study, the effect of increasing the pore size on cellular infiltration was studied in poly‌caprolactone (PCL)/nanohydroxyapatite (nHA) electrospun scaffolds, which were modified using ultrasonication, co-electrospinning with poly (ethylene oxide) (PEO), and a combination of both. Ultrasonic process was optimized by central composite design (CCD)...
March 3, 2017: Journal of Biomedical Materials Research. Part A
Asma Sadat Motamedi, Hamid Mirzadeh, Fereshteh Hajiesmaeilbaigi, Shadab Bagheri Khoulenjani, Mohammad Ali Shokrgozar
In this study, gold nanoparticles/Polyvinylidenefluoride composite electrospun mat with enhanced piezoelectricity were fabricated and characterized. Gold colloidal nanoparticles (Au NPs) were prepared via laser ablation of metallic targets in liquid media. The active Q-switched Nd:YAG laser was used as an irradiation source. Then, PVDF (Polyvinylidenefluoride) was dissolved in Au NPs colloidal solution at 30% wt for the synthesis of Au NPs/PVDF composite nanofibers by electrospinning. The optical absorbance spectra of Au NPS and the polymeric solutions were obtained by the UV-Visible spectroscopy...
March 3, 2017: Journal of Biomedical Materials Research. Part A
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