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Journal of Biomedical Materials Research. Part A

Azam Chahardoli, Naser Karimi, Ali Fattahi, Iraj Salimikia
In this work, biosynthesis potentials of Dracocephalum kotschyi leaf extract for the production of gold nanoparticle (AuNPs) were studied, and the biological (catalytic, antibacterial, antioxidant and anticancer) activities of studied AuNPs were evaluated. Different analytical techniques including UV-vis spectroscopy, X-ray diffraction (XRD), fourier transform-Infrared spectroscopy (FT-IR), scanning electron microscope (SEM), energy dispersive X-ray analysis (EDX) and transmission electron microscopy (TEM) were used for the characterization of AuNPs...
November 8, 2018: Journal of Biomedical Materials Research. Part A
Ali Honarpardaz, Shiva Irani, Mohamad Pezeshki-Modaress, Mojgan Zandi, Amin Sadeghi
Tissue engineering is a new technique to help damaged cartilage treatment using cells and scaffolds. In this study we tried to evaluate electrospun scaffolds composed of gelatin/glycosaminoglycan (G/GAG) blend nanofibers in chondrogenesis of bone marrow-derived mesenchymal stem cells (BMMSCs). Scaffolds were fabricated by electrospinning technique with different concentration of glycosaminoglycan (0%, 5%, 10%, and 15%) in gelatin matrix. BMMSCs were cultured on the scaffolds for chondrogenesis process. MTT assay was done for scaffold's biocompatibility and cells viability evaluation...
November 8, 2018: Journal of Biomedical Materials Research. Part A
Jun Chen, Qiuchen Dong, Yikun Huang, Xiaoyu Ma, Tai-Hsi Fan, Zichao Bian, André O'Reilly Beringhs, Xiuling Lu, Yu Lei
A smart hydrogel with dual self-healing and autofluoresent functionalities is presented. The protein hydrogel is fabricated by denaturing bovine serum albumin in a basic environment. Upon gelation, autofluorescence is induced and the protein hydrogel can be excited by a wide range of spectrum, ranging from 320 to 520 nm. It was also found that the as-prepared autofluorescent protein hydrogel possessed rapid and repetitive self-healing capability. Without any external stimulus, more than 90% recovery of the mechanical strength can be obtained within 10 min after destruction...
November 8, 2018: Journal of Biomedical Materials Research. Part A
S Mary Stella, U Vijayalakshmi
In the present investigation, the natural cellulose was extracted from Luffa cylindrica vegetable sponge by Chemical Modification. Both chemically modified and unmodified luffa was characterized by FTIR, XRD, SEM, and EDAX. The chemically modified cellulose was used for the preparation of a nanofibrous scaffold using the electrospinning method. In order to achieve the uniform and bead free fibers with desired fiber diameter the parameters such as applied voltage, tip to collector distance, solution concentration were optimized...
November 8, 2018: Journal of Biomedical Materials Research. Part A
Hiroaki Komuro, Tetsuo Sasano, Naohiro Horiuchi, Kimihiro Yamashita, Akiko Nagai
Surface modification techniques have been employed for the use of biocompatible and bioresorbable hydroxyapatite (HAp) nanoparticles in cell biology and medicine for the delivery of bioactive molecules. We demonstrated the effects of glucose modification of HAp (GlcHAp) on the transfection efficiency in endothelial cells. After preparing homogeneous HAp nanoparticles with a microemulsion technique, the particles with or without glucose modification and plasmid DNA (pDNA) complexes were transfected into endothelial cells...
November 5, 2018: Journal of Biomedical Materials Research. Part A
Krishna Chaitanya Nune, R Devesh Kumar Misra, Yun Bai, Shujun Li, Rui Yang
The objective of this study is to elucidate the elution response of bone morphogenetic protein (BMP-2) in tuning cellular functions on 3D-printed titanium alloy mesh scaffolds subjected to microarc/plasma electrolytic oxidation process. The microtopographical cues enabled strong interaction with BMP-2 protein, which led to controlled release. Furthermore, the interaction of BMP-2 with the surface microtopographical cue regulated osteoblast cellular activity by contributing to the early phase differentiation and mineralization of osteoblasts...
November 5, 2018: Journal of Biomedical Materials Research. Part A
Gabriel J Haas, Andrew J Dunn, Madison Marcinczyk, Muhamed Talovic, Mark Schwartz, Robert Scheidt, Anjali D Patel, Katherine R Hixon, Hady Elmashhady, Sarah H McBride-Gagyi, Scott A Sell, Koyal Garg
Skeletal muscle is inept in regenerating after traumatic injuries due to significant loss of basal lamina and the resident satellite cells. To improve regeneration of skeletal muscle, we have developed biomimetic sponges composed of collagen, gelatin, and laminin (LM)-111 that were crosslinked with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC). Collagen and LM-111 are crucial components of the muscle extracellular matrix and were chosen to impart bioactivity whereas gelatin and EDC were used to provide mechanical strength to the scaffold...
November 5, 2018: Journal of Biomedical Materials Research. Part A
Maryam Ataie, Iman Shabani, Ehsan Seyedjafari
Surface mineralized nanofibrous scaffolds hold great potential for bone tissue engineering applications. In this study, a new hybrid nanofibrous scaffold composed of alginate/poly(L-lactide) nanofibers was fabricated using electrospinning method and then crosslinking process was employed. Hydroxyapatite crystal formation took place using in situ precipitation by immersion of the scaffolds in simulated body fluid solution for 10 days at 37 °C. The morphologies of the scaffolds were observed using scanning electron microscope...
November 3, 2018: Journal of Biomedical Materials Research. Part A
Esin Akbay, Mehmet Ali Onur
Mesenchymal stem cell-derived cardiomyocytes are employed as a source for myocardial cell transplantation as well as for tissue engineering in decellularized tissue scaffolds. The present study aimed to investigate the survival and migration potential of differentiated cardiomyocytes integrated to decellularized scaffolds after implantation into retroperitoneum of rats, and to assess the feasibility of their ectopic use for future cardiovascular tissue engineering. For this purpose, adipose tissue derived mesenchymal stem cells (AdMSCs) were first isolated...
November 3, 2018: Journal of Biomedical Materials Research. Part A
Jobanpreet Dhillon, Stuart A Young, Stephen E Sherman, Gillian I Bell, Brian G Amsden, David A Hess, Lauren E Flynn
Cell-based therapies involving the injection of adipose-derived stem/stromal cells (ASCs) within rationally-designed biomaterials are a promising approach for stimulating angiogenesis. With this focus, the current work explored the effects of incorporating integrin-binding RGD or IKVAV peptides within in situ-gelling N-methacrylate glycol chitosan (MGC) hydrogels on the response of encapsulated human ASCs. Initial studies focused on hydrogel characterization to validate that the MGC, MGC-RGD and MGC-IKVAV hydrogels had similar biomechanical properties...
November 3, 2018: Journal of Biomedical Materials Research. Part A
Yanru Wu, Yun Gyeong Kang, Hana Cho, In Gul Kim, Eun-Jae Chung, Jung-Woog Shin
Even the efficacy of substrate and mechanical stimuli in addition to biochemical cues have been recognized in many studies of stem cell differentiation, few studies have been reported on the differentiation into esophageal epithelial cells. Therefore the aim of this study was set to propose a method of differentiating stem cells into esophageal epithelial cells according to biochemical reagent concentration, substrate properties, and mechanical forces. After the concentration of ATRA was determined as 5 μM by a baseline experiment, the degree of differentiation was compared in three different kinds of substrates: cover glass, polyurethane(PU) membrane, and electrospun PU sheet(ePU)...
November 3, 2018: Journal of Biomedical Materials Research. Part A
Avraham Dayan, Raphael Lamed, Dafna Benayahu, Gideon Fleminger
Titanium and its alloys are widely used in dental- and orthopedic implants, the outer surface of which is often oxidized to titanium dioxide (TiO2 ). To achieve efficient osseointegration with bone-forming cells, it is desirable to counter the formation of the soft fibrous tissue around the implant by creating strong and stable interactions between the implant surface and bone-forming osteoblasts. To address this challenge a bioactive coating had to be designed. Protein adsorption to TiO2 is well known in the literature, but it is mostly characterized by weak associations, rendering less efficient implant osseointegration...
November 3, 2018: Journal of Biomedical Materials Research. Part A
Daniel Browe, Joseph Freeman
Advancements in tissue engineering and biomaterial development have the potential to provide a scalable solution to the problem of large-volume skeletal muscle defects. Previous research on the development of scaffolds for skeletal muscle regeneration has focused on strategies for increasing conductivity, which has improved satellite cell attachment and differentiation. However, these strategies usually increase scaffold stiffness, which some studies suggest may be detrimental to myoblast development. In this study, the polymers polypyrrole (PPy) and polycaprolactone (PCL) were synthesized together into a copolymer (PPy-PCL) designed to increase scaffold conductivity without significantly influencing stiffness...
October 31, 2018: Journal of Biomedical Materials Research. Part A
Chenyu Chu, Shimin Wei, Yuanjing Wang, Yufei Wang, Yi Man, Yili Qu
Transplanting mesenchymal stem cells (MSCs) has been widely perceived as an ideal treatment for bone repair and regeneration, owing to their differential potential. However, researchers found that very few intravenous MSCs could stay in the target tissue, whereas the majority of them are trapped in liver, spleen, and lung, largely reducing its therapeutic effects. Recently, extracellular vesicles (EVs) have attracted increased attention due to their function in bone repair and advantages over traditional cell therapy...
October 31, 2018: Journal of Biomedical Materials Research. Part A
Aida Shakouri-Motlagh, Andrea J O'Connor, Bill Kalionis, Daniel E Heath
Coatings produced from extracellular matrixes (ECMs) have emerged as promising surfaces for the improved ex vivo expansion of mesenchymal stem cells (MSCs). However, identifying a readily available source of ECM to generate these coatings is currently the bottleneck of this technology. In this study, we assessed if ECM coatings derived from decellularized fetal membranes were a suitable substrate for MSC expansion. We separated and decellularized the two main components of the fetal membranes, the amnion and the chorion...
October 31, 2018: Journal of Biomedical Materials Research. Part A
Mohammad Hadi Norahan, Masoud Amroon, Ramin Ghahremanzadeh, Mahboobeh Mahmoodi, Nafiseh Baheiraei
The application of a cardiac patch over the epicardial surface has shown positive effects in protecting cardiac function postinfarction. Electroactive patches could enhance electrical signal propagation among cardiac cells. In the present study, an electrically active composite of collagen and graphene oxide (Col-GO) was fabricated as a cardiac patch. Col scaffolds were fabricated using a freeze-drying method and coated covalently with GO. Some scaffolds were also reduced by a reduction agent to restore the high conductivity of GO...
October 29, 2018: Journal of Biomedical Materials Research. Part A
Bryan J Black, Melanie Ecker, Allison Stiller, Rashed Rihani, Vindhya Reddy Danda, Isabella Reed, Walter E Voit, Joseph J Pancrazio
Shape memory polymers (SMPs) based on thiol-ene/acrylate formulations are an emerging class of materials with potential applications as structural and/or dielectric coatings for implantable neural interfaces. Here, we report in vitro compatibility studies of three novel thiol-ene/acrylate-based SMP formulations. In vivo cytotoxicity assays were carried out in accordance with International Organization for Standards (ISO) protocol 10993-5, using NCTC clone 929 fibroblasts as well as embryonic cortical cultures...
October 29, 2018: Journal of Biomedical Materials Research. Part A
Timothy M Brenza, Benjamin W Schlichtmann, Biju Bhargavan, Julia E Vela Ramirez, Rainie D Nelson, Matthew G Panthani, JoEllyn M McMillan, Balaraman Kalyanaraman, Howard E Gendelman, Vellareddy Anantharam, Anumantha G Kanthasamy, Surya K Mallapragada, Balaji Narasimhan, Georgette D Kanmogne
An urgent need to deliver therapeutics across the blood-brain barrier (BBB) underlies a paucity of effective therapies currently available for treatment of degenerative, infectious, traumatic, chemical, and metabolic disorders of the nervous system. With an eye toward achieving this goal, an in vitro BBB model was employed to simulate biodegradable polyanhydride nanoparticle-based drug delivery to the brain. Using a combination of confocal microscopy, flow cytometry, and high performance liquid chromatography, we examined the potential of polyanhydride nanoparticles containing the anti-oxidant, mito-apocynin, to be internalized and then transferred from monocytes to human brain microvascular endothelial cells...
October 26, 2018: Journal of Biomedical Materials Research. Part A
Xiaolin Cui, Yusak Hartanto, Chengtie Wu, Jingxiu Bi, Sheng Dai, Hu Zhang
Tumor spheroids are considered to be effective in drug screening and evaluation. Three-dimensional scaffold-based cell culture becomes very promising in producing multicellular spheroids. Different from other approaches, 3D scaffolds mimic in vivo cellular microenvironment which encourages intercellular and extracellular interactions. The properties of the cellular microenvironment include the surface wettability, chemistry, and charge of the scaffolds which may influence cell attachment, proliferation as well as migration and these properties are essential for multicellular spheroids formation...
October 26, 2018: Journal of Biomedical Materials Research. Part A
Jazmín I González Ocampo, Nicole Bassous, Claudia P Ossa Orozco, Thomas J Webster
A successful post-surgical implant is associated with accelerated recovery periods, involving the efficient regeneration of lost or non-viable tissue and a reduction in microbial growth. Alternatively, the long-term success of an implant is guided by the selection of an engineered biomimetic material that is biocompatible, non-biodegradable, and stable at the site of implantation, without invoking any non-essential or undesirable biological responses. The potential for developing an injectable bone substitute (IBS) was investigated here...
October 26, 2018: Journal of Biomedical Materials Research. Part A
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