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Journal of Biomedical Materials Research. Part A

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https://www.readbyqxmd.com/read/28218496/functional-analysis-of-bioactivated-surfaces
#1
Selgai Haidari, Marko Boskov, Ulrike Schillinger, Klaus-Dietrich Wolff, Christian Plank, Andreas Kolk
Common scaffold surfaces, such as titanium, can have side effects, e.g., infections, cytotoxicity, impaired osseointegration or low regeneration rates for bone tissue. These effects lead to poor implant integration or even implant loss. Therefore, bioactive implants are promising instruments in tissue regeneration. Osteoinductive elements, such as growth factors and anti-infectives, support wound healing and bone growth and thereby enable faster osseointegration, even in elderly patients. In this study, titanium surfaces were coated with a poly-(D,L-lactide) (PDLLA) layer containing different concentrations of copolymer-protected gene vectors (COPROGs) to locally provide bone morphogenetic protein-2 (BMP-2) or activated anti-infective agents, such as chlorhexidine gluconate, triclosan and metronidazole, to prevent peri-implantitis...
February 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28218494/influence-of-oxygen-levels-on-chondrogenesis-of-porcine-mesenchymal-stem-cells-cultured-in-polycaprolactone-scaffolds
#2
Joaquin Rodenas-Rochina, Daniel J Kelly, Jose Luis Gómez Ribelles, Myriam Lebourg
Chondrogenesis of Mesenchymal stem cells (MSCs) is known to be regulated by a number of environmental factors, including local oxygen levels. The hypothesis of this study is that the response of MSCs to hypoxia is dependent on the physical and chemical characteristics of the substrate used. The objective of this study was to explore how different modifications to polycaprolactone (PCL) scaffolds influenced the response of MSCs to hypoxia. PCL, PCL-hyaluronic acid (HA) and PCL-Bioglass® (BG) scaffolds were seeded with MSCs derived from bone marrow and cultured for 35 days under normoxic or low oxygen conditions, and the resulting biochemical properties of the MSC laden construct were assessed...
February 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28218484/vibrational-analysis-of-implants-and-tissues-calibration-and-mechanical-spectroscopy-of-multi-component-materials
#3
Ruchit G Shah, Dale DeVore, Mark C Pierce, Frederick H Silver
Several new methods have been used to non-destructively evaluate the mechanical properties of materials and tissues including magnetic resonance elastography (MRE), ultrasound elastography (UE), optical coherence elastography (OCE) and various forms of vibrational analysis. One of the limitations of using these methods is the need to establish a relationship between the modulus measured using each new technique and moduli measured using well-established techniques such as constant rate-of-strain and incremental stress-strain curves...
February 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28218482/osteoblastic-differentiation-of-periodontal-ligament-stem-cells-on-non-stoichiometric-calcium-phosphate-and-titanium-surfaces
#4
L Winning, L Robinson, A R Boyd, I A El Karim, F T Lundy, B J Meenan
Bioactive materials offer particular clinical benefits in the field of dental implantology, where differentiation of stem cells towards an osteoblastic lineage is required for osseointegration and appropriate function of implants in vivo. The aim of this study was to evaluate the osteoblastic response of Stro-1+ve periodontal ligament stem cells (PDLSCs) to three well-characterised biomaterial surfaces: an abraded titanium surface (cpTi) control; a polycrystalline titanium surface, with both micro and nano-topography produced by radio frequency magnetron sputtering (TiTi); and the same surface incorporating a sputter deposited calcium phosphate coating (CaP-TiTi)...
February 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28218444/evaluation-of-late-outgrowth-endothelial-progenitor-cell-and-umbilical-vein-endothelial-cell-responses-to-thromboresistant-collagen-mimetic-hydrogels
#5
Dany J Munoz-Pinto, Josh D Erndt-Marino, Silvia M Becerra-Bayona, Viviana R Guiza-Arguello, Satyavrata Samavedi, Sarah Malmut, William M Reichert, Brooke Russell, Magnus Hӧӧk, Mariah S Hahn
Bioactive coatings which support the adhesion of late-outgrowth peripheral blood endothelial progenitor cells (EOCs) are actively being investigated as a means to promote rapid endothelialization of "off-the-shelf," small-caliber arterial graft prostheses following implantation. In the present work, we evaluated the behavior of EOCs on thromboresistant graft coatings based on the collagen-mimetic protein Scl2-2 and poly(ethylene glycol) (PEG) diacrylate. Specifically, the attachment, proliferation, migration, and phenotype of EOCs on PEG-Scl2-2 hydrogels were evaluated as a function of Scl2-2 concentration (4, 8, and 12 mg/mL) relative to human umbilical vein endothelial cells (HUVECs)...
February 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28205372/zein-based-composites-in-biomedical-applications
#6
Merve Demir, Laura Ramos-Rivera, Raquel Silva, Showan N Nazhat, Aldo R Boccaccini
Considerable research efforts have been devoted to zein based biomaterials for tissue engineering and other biomedical applications over the past decade. The attention given to zein based polymers is primarily attributed to their biocompatibility and biodegradability. However, due to the relatively low mechanical properties of these polymers, numerous inorganic compounds (e.g, hydroxyapatite, calcium phosphate, bioactive glasses, natural clays) have been considered in combination with zein to create composite materials in an attempt to enhance zein mechanical properties...
February 16, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28198136/morphological-and-growth-responses-of-vascular-smooth-muscle-and-endothelial-cells-cultured-on-immobilized-heparin-and-dextran-sulfate-surfaces
#7
Irina S Robu, Henry L Walters, Howard W T Matthew
Heparin has shown promise as a component of various biomaterial formulations, but its variable properties and inhibitory effects on some cell types have raised interest in use of dextran sulfate as an alternative. In this study, we characterized the interactions of vascular smooth muscle (SMC) and endothelial cells (EC) with heparin and dextran sulfate immobilized onto chitosan-based films. Films were modified by blending chitosan with type I collagen and covalently attaching heparin or dextran sulfate at various levels...
February 15, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28198135/hierarchically-ordered-polymer-nanofiber-shish-kebabs-as-a-bone-scaffold-material
#8
Xi Chen, Sarah E Gleeson, Tony Yu, Nasreen Khan, Robert W Yucha, Michele Marcolongo, Christopher Y Li
The ideal bone scaffold harnesses the body's ability to regenerate bone in critical size defects. A potential strategy to design the ideal bone scaffold is to mimic the natural structure of bone at the molecular level. The orientation and spatial distribution of nanocrystals in the organic matrix are two important and distinctive structural characteristics associated with natural bone. There has yet to be a synthetic system or scaffold that is able to control both the spatial distribution and orientation of the HAP crystalline structure...
February 15, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28198131/development-of-multi-substituted-hydroxyapatite-nanopowders-as-biomedical-materials-for-bone-tissue-engineering-applications
#9
Yanny M Baba Ismail, Ian Wimpenny, Oana Bretcanu, Kenneth Dalgarno, Alicia J El Haj
Ionic substitutions have been proposed as a tool to control the functional behavior of synthetic hydroxyapatite (HA), particularly for Bone Tissue Engineering (BTE) applications. The effect of simultaneous substitution of different levels of carbonate (CO3 ) and silicon (Si) ions in the HA lattice was investigated. Furthermore, human bone marrow-derived mesenchymal stem cells (hMSCs) were cultured on multi-substituted HA (SiCHA) to determine if biomimetic chemical compositions were osteoconductive. Of the four different compositions investigates, SiCHA-1 (0...
February 15, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28188686/toxic-effects-of-tio2-nanoparticles-in-primary-cultured-rat-sertoli-cells-are-mediated-via-a-dysregulated-ca-2-pkc-p38-mapk-nf-%C3%AE%C2%BAb-cascade
#10
Lingqun Ye, Fashui Hong, Xiao Ze, Lingjuan Li, Yaoming Zhou, Yuguan Ze
Although numerous studies have demonstrated that titanium dioxide nanoparticles (TiO2 NPs) can be accumulated in various animal organs and can cause toxicity, there is currently only limited data regarding reproductive toxicity especially on the toxic mechanisms of TiO2 NPs in Sertoli cells. In order to investigate the mechanism of reproductive toxicity, primary cultured rat Sertoli cells were exposed to 5, 15 or 30 μg/ml TiO2 NPs for 24 h, and TiO2 NPs internalization, expression of PKC (p-PKC) and p38 MAPK (p-p38 MAPK) as well as calcium homeostasis were examined...
February 11, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28187519/development-of-a-novel-alginate-polyvinyl-alcohol-hydroxyapatite-hydrogel-for-3d-bioprinting-bone-tissue-engineered-scaffolds
#11
Stephanie T Bendtsen, Sean P Quinnell, Mei Wei
3D printed biomaterials used as personalized tissue substitutes have the ability to promote and enhance regeneration in areas of defected tissue. The challenge with 3D printing for bone tissue engineering remains the selection of a material with optimal rheological properties for printing in addition to biocompatibility and capacity for uniform cell incorporation. Hydrogel biomaterials may provide sufficient printability to allow cell encapsulation and bioprinting of scaffolds with uniform cell distribution...
February 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28187512/a-review-of-gradient-stiffness-hydrogels-used-in-tissue-engineering-and-regenerative-medicine
#12
REVIEW
Xia Tingting, Liu Wanqian, Yang Li
Substrate stiffness is known to impact characteristics including cell differentiation, proliferation, migration and apoptosis. Hydrogels are polymeric materials distinguished by high water content and diverse physical properties. Gradient stiffness hydrogels are designed by the need to develop biologically friendly materials as extracellular matrix (ECM) alternatives to replace the separated and narrow-ranged hydrogel substrates. Important new discoveries in cell behaviors have been realized with model gradient stiffness hydrogel systems from the two-dimensional (2D) to three-dimensional (3D) scale...
February 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28187505/study-of-the-dual-effect-of-gamma-irradiation-and-strontium-substitution-on-bioactivity-cytotoxicity-and-antimicrobial-properties-of-45s5-bioglass
#13
M M Farag, W M Abd-Allah, Hanaa Y A Ahmed
In this work, we studied simultaneous effect of gamma irradiation and SrO substitution for Na2 O on bioactivity, cytotoxicity and antimicrobial properties of 45S5 glass. Gamma irradiation was mainly introduced in this work as an effective sterilizing technique, improvement of bulk properties and surface modification of glass. Where, gamma irradiation is considered a modifier for glass network due to generation of defects resulted from this irradiation. Furthermore, SrO was introduced into the glass structure in place of Na2 O in order to reduce a probable toxic effect of Na2 O for surrounding tissue by decreasing its percentage...
February 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28177593/development-and-characterization-of-stimuli-responsive-hydrogel-microcarriers-for-oral-protein-delivery
#14
Colleen O'Connor, Stephanie Steichen, Nicholas A Peppas
A family of pH-responsive terpolymers composed of methacrylic acid (MAA), N-vinyl pyrrolidone (NVP), and poly(ethylene glycol) monomethylether monomethacrylate (PEGMMA) have been developed and evaluated for their pH-responsive swelling behavior, protein loading capabilities, and cytocompatibility. These terpolymer hydrogels, designated as P((MAA-co-NVP)-g-EG), were synthesized with varying PEG chain lengths and monomer feed ratios. The incorporation of MAA into the terpolymer structure was quantified with potentiometric titration...
February 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28177587/continuous-microfluidic-assembly-of-biodegradable-poly-beta-amino-ester-dna-nanoparticles-for-enhanced-gene-delivery
#15
David R Wilson, Arman Mosenia, Mark P Suprenant, Rahul Upadhya, Denis Routkevitch, Randall A Meyer, Alfredo Quinones-Hinojosa, Jordan J Green
Translation of biomaterial-based nanoparticle formulations to the clinic faces significant challenges including efficacy, safety, consistency and scale-up of manufacturing, and stability during long-term storage. Continuous microfluidic fabrication of polymeric nanoparticles has the potential to alleviate the challenges associated with manufacture, while offering a scalable solution for clinical level production. Poly(beta-amino esters) (PBAE)s are a class of biodegradable cationic polymers that self-assemble with anionic plasmid DNA to form polyplex nanoparticles that have been shown to be effective for transfecting cancer cells specifically in vitro and in vivo...
February 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28177580/pre-coating-of-biphasic-calcium-phosphate-bone-substitute-with-atelocollagen-enhances-bone-regeneration-through-stimulation-of-osteoclast-activation-and-angiogenesis
#16
Beom-Su Kim, Sun-Sik Yang, Jun Lee
Type I collagen (Col) is a naturally polymerizing protein and important extracellular matrix bone component. The aim of this study was to improve bone regeneration capacity by pre-coating the surface of biphasic calcium phosphate (BCP) granules with AT-Col, and evaluating its biological effects. BCP granules were pre-coated with AT-Col using adsorption and lyophilization method. Morphology of AT-Col pre-coated surfaces was observed using scanning electron microscopy (SEM). Biocompatibility and osteogenic activity of AT-Col were determined in vitro with human mesenchymal stem cell (hMSCs)...
February 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28177577/lymph-node-stiffness-mimicking-hydrogels-regulate-human-b-cell-lymphoma-growth-and-cell-surface-receptor-expression-in-a-molecular-subtype-specific-manner
#17
Fnu Apoorva, Ye F Tian, Timothy M Pierpont, David M Bassen, Leandro Cerchietti, Jonathan T Butcher, Robert S Weiss, Ankur Singh
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma, with multiple molecular subtypes. The activated B cell-like DLBCL subtype accounts for roughly one-third of all the cases and has an inferior prognosis. There is a need to develop better class of therapeutics that could target molecular pathways in resistant DLBCLs; however this requires DLBCLs to be studied in representative tumor microenvironments. The pathogenesis and progression of lymphoma has been mostly studied from the point of view of genetic alterations and intracellular pathway dysregulation...
February 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28177574/characterization-of-protein-interactions-with-molecularly-imprinted-hydrogels-that-possess-engineered-affinity-for-high-isoelectric-point-biomarkers
#18
John R Clegg, Justin X Zhong, Afshan S Irani, Joann Gu, David S Spencer, Nicholas A Peppas
Molecularly imprinted polymers (MIPs) with selective affinity for protein biomarkers could find extensive utility as environmentally robust, cost-efficient biomaterials for diagnostic and therapeutic applications. In order to develop recognitive, synthetic biomaterials for prohibitively expensive protein biomarkers, we have developed a molecular imprinting technique that utilizes structurally similar, analogue proteins. Hydrogel microparticles synthesized by molecular imprinting with trypsin, lysozyme, and cytochrome c possessed an increased affinity for alternate high isoelectric point biomarkers both in isolation and plasma-mimicking adsorption conditions...
February 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28177570/studying-the-effect-of-physically-adsorbed-coating-polymers-on-the-cytotoxic-activity-of-optimized-bisdemethoxycurcumin-loaded-plga-nanoparticles
#19
Mina Mehanny, Rania M Hathout, Ahmed S Geneidi, Samar Mansour
The aim of this work was to study the effect of different physically-adsorbed coating polymers on the cytotoxic activity of optimized bisdemethoxycurcumin (BDMC) loaded-PLGA nanoparticles. BDMC-loaded PLGA nanoparticles were prepared adopting the nanoprecipitation technique according to a full factorial study design. The effects of three independent variables each at two levels, namely: the polymer type, polymer concentration and PVA concentration were studied. The particles were optimized regarding particle size and entrapment efficiency where sizes < 200 nm and entrapment efficiencies reaching ∼ 98% were obtained...
February 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28165665/bisphosphonate-functionalized-poly-%C3%AE-amino-ester-network-polymers
#20
Melek Naz Guven, Merve Seckin Altuncu, Fatma Demir Duman, Tugce Nur Eren, Havva Yagci Acar, Duygu Avci
Three novel bisphosphonate-functionalized secondary diamines are synthesized and incorporated into poly(β-amino ester)s (PBAEs) to investigate the effects of bisphosphonates on biodegradation and toxicity of PBAE polymer networks. These three novel amines, BPA1, BPA2 and BPA3, were prepared from the reactions of 1,4-butanediamine, 1,6-hexanediamine or 4,9-dioxa-1,12-dodecanediamine with tetraethyl vinylidene bisphosphonate, respectively. The PBAE macromers were obtained from the aza-Michael addition reaction of these amines to 1,6-hexane diol diacrylate (HDDA) and poly(ethylene glycol) diacrylate (PEGDA, Mn = 575) and photopolymerized to produce biodegradable gels...
February 6, 2017: Journal of Biomedical Materials Research. Part A
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