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Journal of Biomedical Materials Research. Part A

Nayereh Askari, Mardali Yousefpour, Masoud Rajabi
In this research work hydroxyapatite/alumina/YSZ bio nanocomposite coatings on titanium substrate were created by electrophoretic deposition (EPD) and reaction bonding process. By using the EPD process, uniform green form coatings containing HA, YSZ and aluminum particles were produced on titanium. After oxidation of aluminum at 660 ˚C and sintering at 850 ˚C, a dense and adherent HA/Al2 O3 /YSZ coating was produced. Scanning electron microscopy (SEM), X-ray diffractometric (XRD) and mechanical tests were employed to investigate the morphologies, compositions, hardness, toughness and bonding strength of the coatings...
March 13, 2018: Journal of Biomedical Materials Research. Part A
Lili Gao, Mengting Li, Lu Yin, Chanjuan Zhao, Junhong Chen, Jie Zhou, Ke Duan, Bo Feng
Excessive immune responses following the use of implantable, biomaterial-based medical devices represent a substantial challenge for treatment efficacy and patient well-being. Specifically, after implantation, pro-inflammatory M1 macrophages are activated by cytokines such as interferon-γ (IFN-γ) followed by anti-inflammatory M2 macrophages polarized by cytokines including interleukin-4 (IL-4), leading to healing and long-term stability of implants. Here, we report the loading of an immunomodulatory cytokine,IL-4, into TiO2 nanotubes (TNTs) followed by hydrogel coating on the TNTs for subsequent release of IL-4...
March 10, 2018: Journal of Biomedical Materials Research. Part A
Klaudia Pluta, Agnieszka Sobczak-Kupiec, Olga Półtorak, Dagmara Malina, Bożena Tyliszczak
Calcium phosphates (CPs) constitute attractive materials of biomedical applications. Among them particular attention is devoted to bioactive hydroxyapatite (HAp) and bioresorbable tricalcium phosphate (TCP) that possess ability to bind to living bones and can be used clinically as important bone substitutes. Notably, in vivo bone bioactivity can be predicted from apatite formation of bone immersed in SBF fluids. Thus, analyses of behavior of calcium phosphates immersed in various bio fluids are of great importance...
March 9, 2018: Journal of Biomedical Materials Research. Part A
Lauren J Jablonowski, Dolores Conover, Nutte T Teraphongphom, Margaret A Wheatley
This study represents the first attempt to combine surface TRAIL expression and doxorubicin co-encapsulation in a single drug delivery agent in the form of ultrasound-responsive microbubbles that shatter into fragments, or nanoshards, in an ultrasound beam. We compare customized microbubbles of different polymeric shell compositions, and investigate the effect of both shell composition and incorporation of doxorubicin on action against TRAIL-sensitive MDA-MB-231 and TRAIL-resistant MCF7 human breast adenocarcinoma cells...
March 9, 2018: Journal of Biomedical Materials Research. Part A
Chaoxing Zhang, Nathan Driver, Qiaomu Tian, Wensen Jiang, Huinan Liu
Metals are widely used in electrode design for recording neural activities because of their excellent electrical conductivity and mechanical strength. However, there are still serious problems related to these currently used metallic electrodes, including tissue damage due to the mechanical mismatch between metals and neural tissues, fibrosis, and electrode fouling and encapsulation that lead to the loss of signal and eventual failure. In this study, a biocompatible, biodegradable, and conductive electrode was created...
March 9, 2018: Journal of Biomedical Materials Research. Part A
Yingzhi Gu, Yuxing Bai, Dongliang Zhang
The aim of the present study was to construct and compare gelatin-HA-TCP scaffolds with a gelatin-only scaffold and to investigate the effect of the scaffold on osteogenic differentiation of human dental pulp stem cells. We developed a novel scaffold for bone tissue engineering via a solution casting/particle washing method, and the physical and mechanical properties of the scaffolds were examined using scanning electron microscopy and a universal testing machine, respectively. Scaffold cytotoxicity toward hDPSCs was evaluated with the CCK8 method, and hDPSC differentiation was evaluated with an alkaline phosphatase activity assay, alizarin red S staining, and real-time PCR...
March 9, 2018: Journal of Biomedical Materials Research. Part A
Ranran Zhang, Tarek A Elkhooly, Qianli Huang, Xujie Liu, Xing Yang, Hao Yan, Zhiyuan Xiong, Jing Ma, Qingling Feng, Zhijian Shen
To improve the success of medical devices, implants with strong surface bioactivity are urgently required. Coatings with a macroporous structure produced by micro-arc oxidation (MAO) possess advantages, such as strong adhesion to substrate and excellent resistance to wear and corrosion. Mesoporous structures contain pores with sizes of 2-50 nm, which can endow the biomaterials with the ability to enhance osteogenesis and to be loaded with diverse drugs. Thus, in this study, we aimed to evaluate the effects of both macroporous and mesoporous structures using a hierarchical macro/mesoporous structure to modify the titanium implant surface...
March 9, 2018: Journal of Biomedical Materials Research. Part A
Rui Chen, John A Hunt, Sandra Fawcett, Raechelle D'Sa, Riaz Akhtar, Judith M Curran
Silane modification has been proposed as a powerful biomaterial surface modification tool. This is the first comprehensive investigation into effect of silane chain length on the resultant properties of -NH2 silane monolayers (SAMS) and the associated osteoinductive properties of the surface. A range of -NH2 presenting silanes, chain length 3 to 11, were introduced to glass coverslips and characterised using water contact angles, atomic force microscopy, X-ray photoelectron spectroscopy and Ninhydrin assays...
March 1, 2018: Journal of Biomedical Materials Research. Part A
Xing Yang, Yuanyuan Li, Qianli Huang, Xujie Liu, Ranran Zhang, Qingling Feng
Due to its excellent biocompatibility, nanosized hydroxyapatite (nHA) has drawn much attention for various applications in biomedical fields. There are growing concerns about its biosecurity, however, little is known about its effects on adipogenesis. In the present study, nHA with three different sizes were synthesized and the in vitro effects of nHA on cell proliferation and adipogenic differentiation of human mesenchymal stem cells (hMSCs) were investigated. The results clearly show that nHA does not affect the cell viability, the lipids droplets formation, triglyceride (TG) synthesis and the expression of adipogenic marker genes/proteins of hMSCs at the concentrations lower than 50 μg/ml...
February 22, 2018: Journal of Biomedical Materials Research. Part A
F Westhauser, B Reible, M Höllig, R Heller, G Schmidmaier, A Moghaddam
Micro-computed tomography (mCT) belongs to the most powerful tools for the three-dimensional (3D) assessment of bone. While it is possible to refer to landmarks in mCT scans of actual bone structure, the assessment of calcified osteoid within scaffolds is problematic, due to the missing morphological correlates. Therefore, bone formation within scaffolds is mostly analyzed using indirect parameters such as changes in volume or surface alteration, preserving histomorphometry the gold standard in the direct analysis of bone formation...
February 22, 2018: Journal of Biomedical Materials Research. Part A
L Datko Williams, A Farley, M Cupelli, S Alapati, M S Kennedy, D Dean
Dental pulp stromal cells (DPSCs) can be differentiated down lineages known to either express bone or dentin specific protein markers. . Since the differentiation of cells can be heavily influenced by their environment, it may be possible to influence the osteogenic/odontogenic potential of DPSCs by modulating the mechanical properties of substrate on which they are grown. In this study, human DPSCs were grown with and without hydroxyapatite (HA) microparticles on a range of substrates including fibronectin-coated hydrogels and glass substrates, which represented an elastic moduli range of ∼ 3 kPa - 50 GPa, over a 21 day period...
February 22, 2018: Journal of Biomedical Materials Research. Part A
Trevor Stack, Amir Vahabikashi, Mark Johnson, Evan Scott
Increased stiffness of Schlemm's canal endothelial cells (SC cells) is a major contributing factor to the increased pressure characteristic of primary open-angle glaucoma. New treatments for glaucoma are being developed using actin depolymerizers and rho kinase inhibitors to address this increased stiffness. However, these agents have off-target effects and are not as potent as had been hoped. We have developed a micellar nanocarrier assembled from poly(ethylene glycol)-bl-poly(propylene sulfide) copolymers capable of encapsulating latrunculin A (Lat A) with the goal of modulating SC cell stiffness...
February 22, 2018: Journal of Biomedical Materials Research. Part A
Gamze Tan, Mehmet Ali Onur
Gold nanoparticles (AuNPs) have recently emerged as prominent vehicles for many biomedical applications from sensing to delivery. The relevant literature contains conflicting data about the effects of AuNPs on living cells. The aim of present study is the synthesis and characterization of AuNPs at nanoscale, tracking their cellular localization and determining their effects on cell viability, migration and angiogenesis. Within this scope, 19-20 nm AuNPs were synthesized and characterized using various spectrometric techniques to determine their size, shape and surface properties such as charge and texture...
February 22, 2018: Journal of Biomedical Materials Research. Part A
R Hedayati, S M Ahmadi, K Lietaert, N Tümer, Y Li, S Amin Yavari, A A Zadpoor
Magnesium and its alloys have the intrinsic capability of degrading over time in vivo without leaving toxic degradation products. They are therefore suitable for use as biodegradable scaffolds that are replaced by the regenerated tissues. One of the main concerns for such applications, particularly in load-bearing areas, is the sufficient mechanical integrity of the scaffold before sufficient volumes of de novo tissue is generated. In the majority of the previous studies on the effects of biodegradation on the mechanical properties of porous biomaterials, the change in the elastic modulus has been studied...
February 22, 2018: Journal of Biomedical Materials Research. Part A
Sony Pandey, Kusum Rathore, Jed Johnson, Maria Cekanova
Tissue engineering shows great promise for the treatment of degenerative diseases, including bone repair. Polymer nanofibers provide a three-dimensional (3-D) scaffold for attachment and growth of mesenchymal stem cells. Increasing evidence supports that fiber alignment on scaffolds plays a major role in the viability and differentiation of stem cells. We compared the cell viability of canine adipose tissue-derived mesenchymal stem cells (cADMSCs) cultured in the aligned- (NanoAligned™) and random- (NanoECM™) oriented polycaprolactone (PCL) nanofiber-coated plates to control polystyrene tissue culture plates using a proliferation assay...
February 22, 2018: Journal of Biomedical Materials Research. Part A
Akshay A Narkhede, James H Crenshaw, Riley M Manning, Shreyas S Rao
Breast cancer brain metastasis marks the most advanced stage of breast cancer no longer considered curable with a median survival period of ∼ 4-16 months. Apart from the genetic susceptibility (subtype) of breast tumors, brain metastasis is also dictated by the biophysical/chemical interactions of tumor cells with native brain microenvironment, which remain obscure, primarily due to the lack of tunable biomimetic in vitro models. To address this need, we utilized a biomimetic hyaluronic acid (HA) hydrogel platform to elucidate the impact of matrix stiffness on the behavior of MDA-MB-231Br cells, a brain metastasizing variant of the triple negative breast cancer line MDA-MB-231...
February 22, 2018: Journal of Biomedical Materials Research. Part A
Shao-Fei Zhang, Shaoyu Lü, Chunmei Gao, Jiandong Yang, Xiang Yan, Tao Li, Na Wen, Mengjie Huang, Mingzhu Liu
Thrombotic events affect many individuals in a number of ways, all of which can cause significant morbidity and mortality. Nattokinase (NK), as a novel thrombolytic drug, has been used for thrombolytic therapy. It not only possesses plasminogen activator activity, but also directly digests fibrin through limited proteolysis. However, it may undergo inactivation and denaturation in the harsh external environment. In this study, a multiarm-polyethylene glycol-polyglutamic acid peptide dendrimer was fabricated and used as a carrier for NK protection and delivery...
February 22, 2018: Journal of Biomedical Materials Research. Part A
Indong Jun, Kyeongsoo Kim, Yong-Woo Chung, Hyeok Jun Shin, Hyung-Seop Han, James R Edwards, Myoung-Ryul Ok, Yu-Chan Kim, Hyun-Kwang Seok, Heungsoo Shin, Hojeong Jeon
Biological responses on biomaterials occur either on their surface or at the interface. Therefore, surface characterization is an essential step in the fabrication of ideal biomaterials for achieving effective control of the interaction between the material surface and the biological environment. Herein, we applied femtosecond laser ablation on electrospun fibrous scaffolds to fabricate various hierarchical patterns with a focus on the alignment of cells. We investigated the simultaneously stimulated response of cardiomyoblasts based on multiple topographical cues, including scales, oriented directions, and spatial arrangements, in the fibrous scaffolds...
February 22, 2018: Journal of Biomedical Materials Research. Part A
Yuanyuan Xu, Xiao Guo, Shuaitao Yang, Long Li, Peng Zhang, Wei Sun, Changyong Liu, Shengli Mi
Articular cartilage (AC) has gradient features in both mechanics and histology as well as a poor regeneration ability. The repair of AC poses difficulties in both research and the clinic. In this paper, a gradient scaffold based on PLGA-ECM was proposed. Cartilage scaffolds with a three-layer gradient structure were fabricated by PLGA through 3D printing, and the microstructure orientation and pore fabrication were made by dECM injection and directional freezing. The manufactured scaffold has a mechanical strength close to that of real cartilage...
February 20, 2018: Journal of Biomedical Materials Research. Part A
Mamatha M Pillai, J Gopinathan, R Senthil Kumar, G Sathish Kumar, S Shanthakumari, K Santosh Sahanand, Amitava Bhattacharyya, R Selvakumar
Tissue engineered constructs with rapid restoration of mechanical and biological properties remains a challenge, emphasizing the need to develop novel scaffolds. Here we present a multi-component composite 3D scaffold structure with biomimetic reinforcement and biomolecule functionalization for meniscus tissue engineering. The scaffold structure was developed using 3:1 silk fibroin (SF) and polyvinyl alcohol (PVA). Autoclaved eggshell membrane (AESM) powder (1-3%w/v) was used as reinforcement to enhance biomechanical properties...
February 20, 2018: Journal of Biomedical Materials Research. Part A
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