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Journal of Biomedical Materials Research. Part A

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https://www.readbyqxmd.com/read/29341492/development-of-a-bi-modal-in-situ-crosslinking-method-to-achieve-multi-factor-release-from-electrospun-gelatin
#1
Alysha P Kishan, Taneidra Walker, Nick Sears, Thomas Wilems, Elizabeth M Cosgriff-Hernandez
To better mimic native tissue microenvironments, current efforts have moved beyond single growth factor delivery to more complex multiple growth factor delivery with distinct release profiles. Electrospun gelatin, a widely investigated drug delivery vehicle, requires post-processing crosslinking techniques that generate a mesh with uniform crosslinking density, limiting the ability to deliver multiple factors at different rates. Herein, we describe a method to independently control release of multiple factors from a single electrospun gelatin mesh...
January 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29341434/recombinant-collagen-scaffolds-as-substrates-for-human-neural-stem-progenitor-cells
#2
Richard A Que, Janahan Arulmoli, Nancy A Da Silva, Lisa A Flanagan, Szu-Wen Wang
Adhesion to the microenvironment profoundly affects stem cell functions, including proliferation and differentiation, and understanding the interaction of stem cells with the microenvironment is important for controlling their behavior. In this study, we investigated the effects of the integrin binding epitopes GFOGER and IKVAV (natively present in collagen I and laminin, respectively) on human neural stem/progenitor cells (hNSPCs). To test the specificity of these epitopes, GFOGER or IKVAV were placed within the context of recombinant triple-helical collagen III engineered to be devoid of native integrin binding sites...
January 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29341426/biomechanical-histological-and-computed-x-ray-tomographic-analyses-of-hydroxyapatite-coated-peek-implants-in-an-extended-healing-model-in-rabbit
#3
Pär Johansson, Sargon Barkarmo, Mohammed Hawthan, Niccolò Peruzzi, Per Kjellin, Ann Wennerberg
No abstract text is available yet for this article.
January 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29330941/hydrophobic-and-hydrophilic-effects-on-water-structuring-and-adhesion-in-denture-adhesives
#4
Simrone K Gill, Nima Roohpour, Yiran An, Julien E Gautrot, Paul D Topham, Brian J Tighe
Denture adhesives are designed to be moisture-sensitive through the inclusion of a blend of polymer salts with varying degrees of water-sensitivity. This enables the adhesive to mix with saliva in vivo and activate its high tack, through the formation of a mucilaginous layer. We report for the first time, the use of differential scanning calorimetry (DSC) to study a series of hydrophobic and hydrophilic polymeric systems in order to correlate water-structuring behavior with adhesion strength. Adhesive bonding of the more hydrophobic variants was higher than that of a commercial-based control and a more hydrophilic polymer system in both lap shear and tensile configurations...
January 13, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29322635/the-effect-of-cell-density-proximity-and-time-on-the-cytotoxicity-of-magnesium-and-galvanically-coupled-magnesium-titanium-particles-in-vitro
#5
Jua Kim, Jeremy L Gilbert
Magnesium (Mg) and galvanically-coupled magnesium-titanium (Mg-Ti) particles in vitro have been reported previously to kill cells in a dosage-dependent manner. Mg-Ti particles kill cells more effectively than Mg alone, due to the galvanic effect of Mg and Ti. This study further investigated the in vitro cytotoxicity of Mg and Mg-Ti in terms of particle concentration, cell density, time, and proximity. Cell density has an effect on cell viability only at low particle concentrations (below 250 µg/ml), where cell viability dropped only for lower cell densities (5,000-10,000 cells/cm2 ) and not for higher cell densities (20,000-30,000 cells/cm2 ), showing that the particles cannot kill if there are more cells present...
January 11, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29318781/phosphonate-functionalized-poly-%C3%AE-amino-ester-macromers-as-potential-biomaterials
#6
Ece Akyol, Mirac Tatliyuz, Fatma Demir Duman, Melek Naz Guven, Havva Yagci Acar, Duygu Avci
Biodegradability, hemocompatibility, resistance to protein adsorption, and strong interactions with hydroxyapatite (HAP)-based tissues such as dentin, enamel, and bone are important properties of phosphorus-containing biomaterials. Here, novel phosphonate-functionalized poly(β-amino ester) (PBAE) macromers are synthesized through aza-Michael addition of various diacrylates [1,6-hexanediol diacrylate (HDDA), poly(ethylene glycol) diacrylate (PEGDA, Mn =575), 1,4-butanediol diacrylate (BDDA), 1,6-hexanediol ethoxylate diacrylate (HDEDA) and triethylene glycol diacrylate (TEGDA)] and a phosphonate-containing primary amine (diethyl 2-aminoethylphosphonate, A1) efficiently without any catalyst; where replacement of A1 with propyl amine (PA) served as control...
January 10, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29318768/use-of-instrumented-indentation-for-determination-of-mechanical-properties-of-human-cornea-after-uva-crosslinking
#7
Jiri Nohava, Michael Swain, Stefan J Lang, Philip Maier, Sonja Heinzelmann, Thomas Reinhard, Philipp Eberwein
UVA-crosslinking is used for treatment of corneal diseases such as keratoconus in order to stabilize the corneal tissue by crosslinking of the collagen fibers. It has been shown that the crosslinking treatment leads to a stiffening of the central corneal tissue. However, knowledge of lateral extent of the corneal stiffening as well as a systematic study of the mechanical response of human cornea is still missing. In our study we measured the stiffness (elastic modulus) of the anterior surface of healthy and crosslinked human corneas by instrumented indentation using a spherical indenter...
January 10, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29318744/immunoisolating-poly-ethylene-glycol-based-capsules-support-ovarian-tissue-survival-to-restore-endocrine-function
#8
James R Day, Anu David, Alexa L Cichon, Tanay Kulkarni, Marilia Cascalho, Ariella Shikanov
A common irreversible adverse effect of life-saving anticancer treatments is loss of gonadal endocrine function and fertility, calling for a need to focus on post-treatment quality of life. Here, we investigated the use of poly(ethylene glycol)-vinyl sulfone based capsules to support syngeneic donor ovarian tissue for restoration of endocrine function in mice. We designed a dual immunoisolating capsule (PEG-Dual) by tuning the physical properties of the PEG hydrogels and combining proteolytically degradable (PEG-PD) and non-degradable (PEG-NPD) layers to meet the numerous requirements for encapsulation and immunoisolation of ovarian tissue, such as nutrient diffusion and tissue expansion...
January 10, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29316290/a-3d-bioprinted-in-situ-conjugated-co-fabricated-scaffold-for-potential-bone-tissue-engineering-applications
#9
Mduduzi N Sithole, Pradeep Kumar, Lisa C du Toit, Thashree Marimuthu, Yahya E Choonara, Viness Pillay
There is a demand for progressive approaches in bone tissue engineering to repair and regenerate bone defects resulting from trauma or disease. This investigation sought to engineer a single-step in situ conjugated polymeric scaffold employing 3D printing technology as an innovative fabricating tool. A polymeric scaffold was engineered in situ employing sodium alginate as a bio-ink which interacted with a poly(ethyleneimine) solution on bioprinting to form a polyelectrolyte complex through ionic bond formation...
January 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29316238/composite-porous-scaffold-of-polyethylene-glycol-peg-polylactic-acid-pla-support-improved-bone-matrix-deposition-in-vitro-compared-to-pla-only-scaffolds
#10
Birru Bhaskar, Robert Owen, Hossein Bahmaee, Zena Wally, Parcha Sreenivasa Rao, Gwendolen C Reilly
Controllable pore size and architecture are essential properties for tissue-engineering scaffolds to support cell ingrowth colonization. To investigate the effect of PEG addition on porosity and bone-cell behavior, porous Polylactic acid (PLA)-Polyethylene glycol (PEG) scaffolds were developed with varied weight ratios of PLA-PEG (100/0, 90/10, 75/25) using solvent casting and porogen leaching. Sugar 200-300 µm in size was used as a porogen. To assess their suitability for bone tissue engineering, MLO-A5 murine osteoblast cells were cultured and cell metabolic activity, alkaline phosphatase (ALP) activity and bone-matrix production determined (alizarin red S staining for calcium, direct red 80 staining for collagen)...
January 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29316233/development-and-biocompatibility-evaluation-of-biodegradable-bacterial-cellulose-as-a-novel-peripheral-nerve-scaffold
#11
Yuanjing Hou, Xinyu Wang, Jing Yang, Rong Zhu, Zongrui Zhang, Yi Li
Peripheral nerve injury is a serious medical problem and severely affects normal life of patient. Bacterial cellulose (BC) is considered as a novel promising biomaterial for tissue engineering, but the poor biodegradability limits its application. In this study, biodegradable bacterial cellulose scaffolds were prepared with different oxidation degrees (O.Ds.) using sodium periodate, evaluating their potential application in peripheral nerve repair. The chemical structure and surface morphology of the oxidized bacterial cellulose (OBC) scaffolds were characterized using Fourier transform infrared spectroscopy, Wide angle X-ray diffraction and Scanning electron microscope...
January 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29316231/osteogenic-cellular-activity-around-onlaid-octacalcium-phosphate-gelatin-composite-onto-rat-calvaria
#12
Ryosuke Iwama, Takahisa Anada, Yukari Shiwaku, Kaori Tsuchiya, Tetsu Takahashi, Osamu Suzuki
The activity and the distribution of osteogenic cells around octacalcium phosphate (OCP) granules combined with gelatin matrix (OCP/Gel) onlaid on rat calvaria were analyzed histomorphometrically and immunohistochemically during vertical bone augmentation under mechanical or non-mechanical environment until 8 weeks. OCP/Gel disk was placed in subperiosteal pocket on the calvaria with or without polytetrafluoroethylene (PTFE) support. The latter is a non-mechanical stress model to alleviate the mechanical stress from the subcutaneous tissues...
January 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29316218/local-administration-of-nuclear-factor-of-activated-t-cells-nfat-c1-inhibitor-to-suppress-early-resorption-and-inflammation-induced-by-bone-morphogenetic-protein-2
#13
Ri Youn Kim, Yeju Seong, Tae Hyung Cho, Beomseok Lee, In Sook Kim, Soon Jung Hwang
Nuclear factor of activated T cells (NFAT)-c1 is known as a key regulator in osteoclast differentiation and immune response. This study is a follow-up to our previous study showing the anti-resorptive activity of VIVIT, a peptide type NFATc1 inhibitor, using absorbable collagen sponge (ACS). This study aimed to investigate the effective concentration range of local VIVIT that suppresses early excessive osteoclast activation and inflammation induced by high-dose recombinant human bone morphogenetic protein (rhBMP)-2 and concomitantly enhances bone healing in a rat critical-sized calvaria defect model...
January 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29316200/formation-of-nanotubular-tio2-structures-with-varied-surface-characteristics-for-biomaterial-applications
#14
Robinson Aguirre, Mónica Echeverry-Rendón, David Quintero, Juan G Castaño, Martin C Harmsen, Sara Robledo, Félix Echeverría E
Nanotubular structures were generated on the surface of titanium c.p. by anodization technique in an aqueous solution of acetic acid (14% v/v) with different sources of fluoride ion (HF, NaF, NH4 F). The aim of using these three different compounds is to study the effect of the counterion (H+ , Na+ and NH4+ ) on the morphology, wettability and surface free energy of the modified surface. Nanotubes were generated at 10 and 15 V for each anodizing solution. To further improve surface characteristics, the samples were heat-treated at 600°C for 4 hours and at 560°C for 3 hours...
January 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29314724/genipin-cross-linked-type-ii-collagen-scaffold-promotes-the-differentiation-of-adipose-derived-stem-cells-into-nucleus-pulposus-like-cells
#15
Xiaopeng Zhou, Yiqing Tao, Erman Chen, Jingkai Wang, Weijing Fang, Tengfei Zhao, Chengzhen Liang, Fangcai Li, Qixin Chen
Adipose-derived stem cells (ADSCs)-based tissue engineering was a promising method to treat intervertebral disc degeneration. Type II collagen is a native component in the nucleus pulposus (NP), and has the ability to promote ADSCs to differentiate into NP-like cells. In this article, we aimed to establish a genipin-cross-linked three-dimensional (3D) type II collagen scaffold, and determine the biological effects of the scaffold on ADSCs differentiating into a NP-like phenotype. Different concentrations of genipin were used to cross-link the 3D type II collagen scaffold...
January 3, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29314616/3d-extrusion-bioprinting-of-single-and-double-network-hydrogels-containing-dynamic-covalent-crosslinks
#16
Leo L Wang, Christopher B Highley, Yi-Cheun Yeh, Jonathan H Galarraga, Selen Uman, Jason A Burdick
The fabrication of three-dimensional (3D) scaffolds is indispensable to tissue engineering and 3D printing is emerging as an important approach towards this. Hydrogels are often used as inks in extrusion-based 3D printing, including with encapsulated cells; however, numerous challenging requirements exist, including appropriate viscosity, the ability to stabilize after extrusion, and cytocompatibility. Here, we present a shear-thinning and self-healing hydrogel crosslinked through dynamic covalent chemistry for 3D bioprinting...
January 3, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29314595/fabrication-and-characterization-of-polymer-ceramic-nanocomposites-containing-drug-loaded-modified-halloysite-nanotubes
#17
Maedeh Ghaderi-Ghahfarrokhi, Vahid Haddadi-Asl, Seyed Shahrooz Zargarian
Modified halloysite nanotubes (HNT-NH2 and HNT-COOH) were synthesized by a coupling reaction with 3-amino- propyltriethoxysilane (APTES) and maleic anhydride from hydroxyl groups of neat halloysite nanotubes (HNTs). Successful attachment of functional groups onto HNTs was evaluated by FTIR and TGA. XRD was used to study the crystalline structure of scaffolds and the formation of intercalated structure as a result of improved dispersion and decreased agglomeration of modified nanoparticles. Neat HNT, HNT-NH2 and HNT-COOH were subsequently introduced into Polycaprolactone/Pluronic P123 (PCL/P123) electrospun substrate...
January 3, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29314593/in-vivo-immuno-reactivity-analysis-of-the-porous-3d-cs-sio2-and-cs-sio2-ha-hybrids
#18
Mengxia Guo, Yifan Dong, Jiangwei Xiao, Ruicai Gu, Maochao Ding, Tao Huang, Junhua Li, Naru Zhao, Hua Liao
Inorganic/organic hybrid silica-chitosan scaffolds have promising potential for bone defect repair, due to the controllable mechanical properties, degradation behavior and scaffold morphology. However, the precise in vivo immuno-reactivity of silica-chitosan hybrids with various compositions is still poorly defined. In this study, we fabricated the 3D interconnected porous chitosan-silica (CS/SiO2 ) and chitosan-silica-hydroxyapatite (CS/SiO2 /HA) hybrids, through sol-gel process and 3D plotting skill, followed by the naturally or freeze drying separately...
January 3, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29314587/alternative-foaming-agents-for-topical-treatment-of-ulcerative-colitis
#19
Martin Asama, Alex Hall, Yijun Qi, Branden Moreau, Heidi Walthier, Matthew Schaschwary, Blaine Bristow, Qun Wang
Approximately 907,000 Americans currently suffer from ulcerative colitis, a condition characterized by inflammation of the large intestine or rectum. Treatment of this disease often includes anti-inflammatory medication or immunosuppressants. Here foams are an attractive delivery platform, offering relatively high bioavailability, low systemic exposure, and improved patient comfort. However, the surfactants that generate these foams may adversely affect the diseased mucosa. Therefore, this project evaluated two alternative surfactants for use in topical drug delivery platforms: sodium caseinate and L-α-phosphatidylcholine...
January 3, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29314586/novel-large-pore-lightweight-polypropylene-mesh-has-better-biocompatibility-for-rat-model-of-hernia
#20
Wangwang Qiu, Cheng Zhong, Rui Xu, Ting Zou, Fujun Wang, Youben Fan, Lu Wang, Zhili Yang
PURPOSE: Abdominal wall hernias are repaired with tension-free prosthetic materials but there remains a foreign body response (FBR) to commonly used polypropylene mesh. Thus, we should optimize mesh materials to improve the patient outcomes after surgery. MATERIALS AND METHODS: A polypropylene mesh was developed with wrap knitting technique. The physical, mechanical and biocompatible characteristics were tested in a rat abdominal hernia model and compared to ULTRAPRO and Easy Prosthesis...
January 3, 2018: Journal of Biomedical Materials Research. Part A
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