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Journal of Biomedical Materials Research. Part A

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https://www.readbyqxmd.com/read/30216664/electrophoretic-deposition-of-lawsone-loaded-bioactive-glass-bg-chitosan-composite-on-polyetheretherketone-peek-bg-layers-as-antibacterial-and-bioactive-coating
#1
Muhammad Atiq Ur Rehman, Fatih Erdem Bastan, Qaisar Nawaz, Wolfgang H Goldmann, Muhammad Maqbool, Sannakaisa Virtanen, Aldo R Boccaccini
In this study, chitosan/bioactive glass (BG)/lawsone coatings were deposited by electrophoretic deposition (EPD) on polyetheretherketone (PEEK)/BG layers (previously deposited by EPD on 316-L stainless steel) to produce bioactive and antibacterial coatings. First, the EPD of chitosan/BG/lawsone was optimized on stainless steel in terms of suspension stability, homogeneity and thickness of coatings. Subsequently, the optimized EPD parameters were used to produce bioresorbable chitosan/bioactive glass (BG)/lawsone coatings on PEEK/BG layers...
September 14, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30208260/a-3d-in-vitro-model-of-the-dermoepidermal-junction-amenable-to-mechanical-testing
#2
Jangwook P Jung, Wei-Han Lin, Megan J Riddle, Jakub Tolar, Brenda M Ogle
Recessive dystrophic Epidermolysis Bullosa (RDEB) is caused by mutations in collagen-type VII gene critical for the dermoepidermal junction (DEJ) formation. Neither tissues of animal models nor currently available in vitro models are amenable to the quantitative assessment of mechanical adhesion between dermal and epidermal layers. Here, we created a 3D in vitro DEJ model using extracellular matrix (ECM) proteins of the DEJ anchored to a poly(ethylene glycol)-based slab (termed ECM composites) and seeded with human keratinocytes and dermal fibroblasts...
September 12, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30208257/bioactive-composites-based-on-double-network-approach-with-tailored-mechanical-physico-chemical-and-biological-features
#3
Ugo D'Amora, Alfredo Ronca, Maria Grazia Raucci, Hai Lin, Alessandra Soriente, Yujiang Fan, Xingdong Zhang, Luigi Ambrosio
Hyaluronic acid (HA)-based hydrogels are one of the most promising naturally derived biomaterials for tissue engineering applications, as they can play an important role in many key cellular processes. In this study, HA was chemically functionalized with photo-cross-linkable motifs by reacting with methacrylic anhydride (MA) to obtain methacrylated hyaluronic acid (MeHA). A range of MA/HA molar ratios was used to obtain different degrees of substitution (DS) ranging from 3.5% to 74.5%, as showed by nuclear magnetic resonance and attenuated total reflection spectroscopy...
September 12, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30208255/collagen-organization-deposited-by-fibroblasts-encapsulated-in-ph-responsive-methacrylated-alginate-hydrogels
#4
Anuraag Boddupalli, Kaitlin M Bratlie
The pH of dermal wounds shifts from neutral during the inflammatory phase to slightly basic in the tissue remodeling phase. Stage specific wound treatment can be developed using environmentally responsive alginate hydrogels. The chemistry of these networks dictates swelling behavior. Here, we fabricated alginate hydrogels using chain growth, step growth, and combined mixed mode gelation methods to crosslink methacrylated alginate (ALGMA) and gain control over swelling responses. Methacrylation of the alginate network was confirmed through NMR spectroscopy...
September 12, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30194904/adsorption-associated-orientational-changes-of-immunoglobulin-g-and-regulated-phagocytosis-of-staphylococcus-epidermidis
#5
Wenjia Hou, Yi Liu, Botao Zhang, Xiaoyan He, Hua Li
Understanding the adsorption of immunoglobulin G (IgG) on biomaterials surfaces is crucial for design and modification of the surfaces to alleviate inflammatory responses after implantation. Here, we report direct visualization and two-dimensional (2D) image interpretation of the IgG molecule adsorbed on simplified surfaces by single particle electron microscopy and atomic force microscopy. Influence of the orientational changes in adsorbed IgG on phagocytosis of macrophages against Staphylococcus epidermidis is further examined...
September 8, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30194900/fabrication-of-a-bilayer-scaffold-for-small-diameter-vascular-applications
#6
Allison Goins, Vidhya Ramaswamy, Darcy Lichlyter, Antonio Webb, Josephine B Allen
One of the greatest challenges plaguing cardiovascular tissue engineering has been the development of a compliant vascular graft. In this work, we report the development of a synthetic vascular graft with compliance similar to native arteries at physiological pressures. A bilayer scaffold was fabricated from a solid polymeric lumen made from poly(1,8 octanediol-co-citrate) (POC) and a microfibrous medial layer composed of type I collagen, elastin, and POC. Mechanical analysis revealed dynamic compliance, ~6...
September 8, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30194693/quantitative-approaches-of-nanofibers-organization-for-biomedical-patterned-nanofibrous-scaffold-by-image-analysis
#7
Neda Shah Hosseini, Bertrand Simon, Tahani Messaoud, Nabyl Khenoussi, Laurence Schacher, Dominique Adolphe
This study proposes a novel design of a laboratory built static collector using the 3D printing technology. This new collector produces aligned-to-random nanofibers in nanofibrous scaffold through electrospinning process. A design of experiment (DOE), based on response surface, analyzes the effect of the main process parameters; concentration, voltage, and distance; on the responses diameter and orientation. A quantifying approach has been used to investigate the orientation of nanofibers in the produced patterned scaffold through Fourier transforms method...
September 8, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30194716/multifunctional-antioxidant-nanoliposome-mediated-delivery-of-pten-plasmids-restore-the-expression-of-tumor-suppressor-protein-and-induce-apoptosis-in-prostate-cancer-cells
#8
Sanjay Singh, Raghu Asal, Stuti Bhagat
Prostate cancer is the second leading cause of cancer death in men and about one in nine will be diagnosed in his lifetime. Loss of PTEN has been considered as one of the major factors leading to the origin of prostate cancer through modulating PI3K/AKT signaling pathways. In this study, we have prepared a multifunctional antioxidant nanoliposome containing PTEN plasmid and cerium oxide nanoparticles (CeNPs). The efficient delivery of PTEN plasmid to human prostate cancer cells (PC-3) leads to restoration of the expression of lost PTEN protein in the cell cytoplasm...
September 7, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30194710/molecular-layer-deposition-builds-biocompatible-substrates-for-epithelial-cells
#9
Leva Momtazi, Darlene A Dartt, Ola Nilsen, Jon Roger Eidet
The demand for novel biocompatible materials as surface coating in the field of regenerative medicine is high. We explored molecular layer deposition (MLD) technique for building surface coatings and introduced a new group of substrates consisting of amino acids, or nucleobases, and the biocompatible metal titanium. The substrates were built from titanium tetraisopropoxide (TTIP) with l-lysine, glycine, l-aspartic acid, l-arginine, thymine, uracil, and adenine. Substrates based on zirconium chloride and terephthalic acid were also included...
September 7, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30194709/comparison-of-catheter-thrombogenicity-in-a-modified-chandler-loop-model-using-goat-blood
#10
Aaron L Olsen, Michael Long
Thrombogenicity testing is a key component in the development of medical devices intended for contact with blood. The Chandler loop system has previously been used as an in vitro thrombogenicity testing method. In this study, we used a modified version of the Chandler loop model to evaluate its capacity to detect differential thrombogenic potential of different catheter materials using goat blood. We also sought to determine the optimal experimental conditions for detecting the thrombogenicity of catheter material...
September 7, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30194699/mesenchymal-stem-cell-interacted-with-plcl-braided-scaffold-coated-with-poly-l-lysine-hyaluronic-acid-for-ligament-tissue-engineering
#11
Xing Liu, Cédric Laurent, Qiaoyue Du, Laurie Targa, Ghislaine Cauchois, Yun Chen, Xiong Wang, Natalia de Isla
The challenge of finding an adapted scaffold for ligament tissue engineering remains unsolved after years of researches. A technology to fabricate a multilayer braided scaffold with flexible and elastic poly (l-lactide-co-caprolactone) (PLCL 85/15) has been recently pioneered by our team. In this study, polyelectrolyte multilayer films (PEM) with poly-l-lysine (PLL)/ hyaluronic acid (HA) were deposited on this scaffold. After PEM modification, polygonal (PLL) and particle-like (HA) structures were present on the braided scaffold with no significant variation of fibers Young's modulus...
September 7, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30192064/multifunctional-effects-of-a-modification-of-sla-titanium-implant-surface-with-strontium-containing-nanostructures-on-immunoinflammatory-and-osteogenic-cell-function
#12
Sung-Min Choi, Jin-Woo Park
This study investigated the effects of surface modification of clinically available sandblasted/acid-etched (SLA) titanium oral implants with strontium (Sr)-containing nanostructures on both early immunoinflammatory macrophage cell functions and osteogenic stem cell functions. The goal was to provide insight for future surface engineering of titanium implants with multifunctional effects, that is, tissue healing capacity at both the nonosteogenic cell centered initial stage and the subsequent osteogenic cell-governed later stage-osseointegration process...
September 7, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30152030/a-totally-recombinant-fibrin-matrix-for-mesenchymal-stem-cell-culture-and-delivery
#13
Ou Wang, Ayman Ismail, Frank Marco Fabian, Haishuang Lin, Qiang Li, Christian Elowsky, Mark A Carlson, Wilson Burgess, William H Velander, Srivatsan Kidambi, Yuguo Lei
Mesenchymal stem cells (MSCs) have been widely studied for tissue engineering and treating diseases in laboratories, clinical trials, and clinics. Fibrin matrices are often used to culture MSCs or increase the retention of MSCs at the injection site. However, fibrins made with the human plasma derived fibrinogen have high cost and risk of human pathogen transmission. In this article, we studied if fibrin matrices made with recombinant human fibrinogen, recombinant human thrombin, and recombinant human factor XIII could be used to culture and deliver MSCs...
August 27, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30151978/composite-tendon-implant-based-on-nanofibrillar-polyhydroxybutyrate-and-polyamide-filaments
#14
Anatoly Olkhov, Vladimir Gur'ev, Vladimir Akatov, Elena Mastalygina, Alexey Iordanskii, Victor I Sevastyanov
The composite material based on reinforcement of polyamide filaments enclosed by a nonwoven matrix of nanoscaled bioresorbable poly(3-hydroxybutyrate) fibers was developed for application as an artificial ligament implant. The aim of this study was to investigate biodegradability and biocompatibility of the developed implant, as well as its stress-strain properties. The study results show the polyamide core of the implant has stress-strain properties comparable with a natural ligament. Simultaneously, the polyhydroxybutyrate external layer provides high biocompatibility and bioresorbability of the developed implant...
August 27, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30151943/the-effect-of-the-inflammatory-species-hypochlorous-acid-on-the-corrosion-and-surface-damage-of-ti-6al-4v-and-cocrmo-alloys
#15
Gregory W Kubacki, Jeremy L Gilbert
Performance of metallic orthopedic alloys is dependent on the local biological conditions within the joint. Inflammation within a joint can lead to severe conditions at the surface of the implant and may represent a driving force of corrosion which is not well understood. In this study, the corrosion response of CoCrMo and Ti-6Al-4V alloys was studied in hypochlorous acid (HOCl) saline solutions, which served as a simulated inflammatory environment. Anodic polarization and electrochemical impedance spectroscopy were used to evaluate the electrochemical behavior of these alloys in a range of hypochlorous acid solutions...
August 27, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30151859/micropillar-based-culture-platform-induces-epithelial-mesenchymal-transition-in-the-alveolar-epithelial-cell-line
#16
Xiaoli Xu, Lunkun Ma, Yanjiao Wu, Liling Tang
Topography and rigidity are two typical biophysical cues in extracellular matrix mechanical microenvironment. Extracellular matrix can regulate cells biological behaviors, including epithelial-to-mesenchymal transition (EMT). A growing body of evidence suggests that EMT plays an important role in the development of tumor and fibrosis. Moreover, EMT also contributes to drug resistance in cancer cells. Currently, the majority of studies about EMT are based on the induction of growth factors or cytokines in vitro...
August 27, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30133124/biomineralization-improves-mechanical-and-osteogenic-properties-of-multilayer-modified-plga-porous-scaffolds
#17
Junchao Kong, Bo Wei, Thomas Groth, Zhuming Chen, Lihua Li, Dongning He, Rui Huang, Jiaqi Chu, Mingyan Zhao
Poly-(lactide-co-glycolide acid) (PLGA) has been widely investigated as scaffold material for bone tissue engineering owing to its biosafety, biodegradability, and biocompatibility. However, the bioinert surface of PLGA may fail in regulating cellular behavior and directing osteointegration between the scaffold and the host tissue. In this article, oxidized chondroitin sulfate (oCS) and type I collagen (Col I) were assembled onto PLGA surface via layer by layer technique (LbL) as an adhesive coating for the attachment of inorganic minerals...
August 21, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30084534/nf%C3%AE%C2%BAb-sensing-il-4-secreting-mesenchymal-stem-cells-mitigate-the-proinflammatory-response-of-macrophages-exposed-to-polyethylene-wear-particles
#18
Tzuhua Lin, Yusuke Kohno, Jhih-Fong Huang, Monica Romero-Lopez, Jukka Pajarinen, Masahiro Maruyama, Karthik Nathan, Zhenyu Yao, Stuart B Goodman
Total joint replacement is a highly effective treatment for patients with end-stage arthritis. Proinflammatory macrophages (M1) mediate wear particle-associated inflammation and bone loss. Anti-inflammatory macrophages (M2) help resolve tissue damage and favor bone regeneration. Mesenchymal stem cell (MSC)-based therapy mitigates the M1 dominated inflammatory reaction and favorably modulates the bone remodeling process. In the current study, the immunomodulating ability of (1) unmodified MSCs, (2) MSCs preconditioned by NFκB stimulating ligands [lipopolysaccharide (LPS) plus TNFα], and (3) genetically modified MSCs that secrete IL-4 as a response to NFκB activation (NFκB-IL4) was compared in a macrophage/MSC co-culture system...
August 7, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30055042/adhesion-and-differentiation-behaviors-of-mesenchymal-stem-cells-on-titanium-with-micrometer-and-nanometer-scale-grid-patterns-produced-by-femtosecond-laser-irradiation
#19
Peng Chen, Toshihiro Aso, Ryuichiro Sasaki, Maki Ashida, Yusuke Tsutsumi, Hisashi Doi, Takao Hanawa
To clarify the effects of grid topographies with different scales on cell morphology and functionalization, we investigated the adhesion and differentiation of human mesenchymal stem cells (hMSCs) to titanium surfaces with micron, nano, and micron/nano (hybrid) grid topographies created by femtosecond laser irradiation. The results showed that cellular adhesion and differentiation strongly depended on the scales of the grid topography. hMSCs cultured on micron and hybrid grid topographies showed regulation of cellular adhesion plaques following the surface topography and were vinculin-positive, whereas filamentous vinculin was evident at the filopodia of hMSCs cultured on nanogrids...
July 28, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30054959/colloidal-gelatin-microgels-with-tunable-elasticity-support-the-viability-and-differentiation-of-mesenchymal-stem-cells-under-pro-inflammatory-conditions
#20
Baeckkyoung Sung, Jess Krieger, Bing Yu, Min-Ho Kim
Despite a promising potential for mesenchymal stem cells (MSCs) in tissue regeneration, a major challenge in MSC-based therapy has been associated with poor cell survival and low levels of cell integration into host tissue following transplantation. The objective of this study was to develop a gelatin-based colloidal microgel platform that enables the encapsulation of viable MSCs as well as confer fine-tuning of mechanical stiffness and low cytotoxicity. In this study, we report a facile method of fabricating gelatin-based microgel spheres for the encapsulation of MSCs using a water-in-oil mini-emulsification method, which is covalently crosslinked by genipin...
July 28, 2018: Journal of Biomedical Materials Research. Part A
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