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Journal of Biomedical Materials Research. Part A

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https://www.readbyqxmd.com/read/28913955/controlled-jagged1-delivery-induces-human-embryonic-palate-mesenchymal-cells-to-form-osteoblasts
#1
Jean De La Croix Ndong, Stephenson Yvonne, Michael E Davis, Andrés J García, Steven Goudy
Osteoblast commitment and differentiation are controlled by multiple growth factors including members of the Notch signaling pathway. JAGGED1 is a cell surface ligand of the Notch pathway that is necessary for murine bone formation. The delivery of JAGGED1 to induce bone formation is complicated by its need to be presented in a bound form to allow for proper Notch receptor signaling. In this study we investigate whether the sustained release of JAGGED1 stimulates human mesenchymal cells to commit to osteoblast cell fate using polyethylene glycol malemeide (PEG-MAL) hydrogel delivery system...
September 15, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28913909/local-delivery-of-strontium-ranelate-promotes-regeneration-of-critical-size-bone-defects-filled-with-collagen-sponge
#2
Bárbara Furtado Masalskas, Walter Martins Júnior, Graziela Bianchi Leoni, Ana Paula de Souza Faloni, Andrea Márcia Marcaccini, Yara Teresinha Corrêa Silva Sousa, Larissa Moreira Spinola de Castro-Raucci
The effect of local delivery of strontium ranelate (SR) on bone regeneration of critical size bone defects filled with collagen sponge was evaluated. Bone defects of 5 mm diameter created in rat calvaria were filled with collagen sponge (C); collagen sponge with 5 mM Sr(2+) SR (C5SR) or collagen sponge with 50 mM Sr(2+) SR (C50SR). After 2, 4 and 6 weeks, bone volume (BV), bone surface (BS), trabecular thickness (Tb.Th), trabecular number (Tb.N) and trabecular separation (Tb.Sp) were evaluated by computed microtomography...
September 15, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28891249/poly-vinylphosphonic-acid-co-acrylic-acid-hydrogels-the-effect-of-copolymer-composition-on-osteoblast-adhesion-and-proliferation
#3
Rebecca E Dey, Ian Wimpenny, Julie E Gough, David C Watts, Peter M Budd
There is a clinical need for a synthetic bone graft substitute that can be used at sites of surgical intervention to promote bone regeneration. Poly(vinylphosphonic acid-co-acrylic acid) (PVPA-co-AA) has recently been identified as a potential candidate for use in bone tissue scaffolds. It is hypothesised that PVPA-co-AA can bind to divalent calcium ions on bone mineral surfaces to control matrix mineralisation and promote bone formation. In this study, hydrogels of PVPA-co-AA have been produced and the effect of copolymer composition on the structure and properties of the gels was investigated...
September 11, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28891231/development-and-characterization-of-electrosprayed-nanoparticles-for-encapsulation-of-curcumin
#4
Zahra Esmaili, Samaneh Bayrami, Farid Abedin Dorkoosh, Hamid Akbari Javar, Ehsan Seyedjafari, Seyed Shahrooz Zargarian, Vahid Haddadi-Asl
Curcumin has been proven to be an effective herbal derived anti-inflammatory and antioxidant biocompatible agent. In this research PLGA (as a biocompatible and GRAS polymer) nanoparticles containing Curcumin were electrospryed from different polymeric solutions with different concentrations for the first time. Morphology of these nanoparticles in the absence/presence of Curcumin was evaluated by SEM, TEM and XPS analyses. Perfectly shaped nanoparticles with an average size of 300 and 320 nanometers were observed for neat and Curcumin loaded PLGA, respectively...
September 11, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28891122/nerve-speci%C3%AF-c-xenogeneic-extracellular-matrix-hydrogel-promotes-recovery-following-peripheral-nerve-injury
#5
Travis A Prest, Eric Yeager, Samuel T LoPresti, Emilija Zygelyte, Matthew J Martin, Longying Dong, Alexis Gibson, Oluyinka O Olutoye, Bryan N Brown, Jonathan Cheetham
Peripheral nerve possesses the inherent ability to regrow and recover following injury. However, nerve regeneration is often slow and incomplete due to limitations associated with the local microenvironment during the repair process. Manipulation of the local microenvironment at the site of nerve repair, therefore, represents a significant opportunity for improvement in downstream outcomes. Macrophages and Schwann cells play a key role in the orchestration of early events after peripheral nerve injury. We describe the production, characterization, and use of an injectable, peripheral nerve-specific extracellular matrix-based hydrogel (PNSECM) for promoting modulation of the local macrophage and Schwann cell responses at the site of nerve repair in a rodent model of sciatic nerve injury...
September 11, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28891247/synthesis-of-dual-thermo-and-ph-sensitive-poly-n-isopropylacrylamide-co-acrylic-acid-grafted-cellulose-nanocrystals-by-reversible-addition-fragmentation-chain-transfer-polymerization
#6
Elnaz Zeinali, Vahid Haddadi-Asl, Hossein Roghani-Mamaqani
Free and cellulose nanocrystals (CNC)-grafted block copolymers of acrylic acid and N-isopropylacrylamide with various poly (N-isopropylacrylamide) (PNIPAAm) block lengths as dual temperature- and pH-sensitive materials were synthesized by RAFT polymerization via an R-approach method. Controlling LCST of the products by changing the PNIPAAm block length, addition of CNC, and variation of pH was studied. The free and CNC-grafted block copolymers were analyzed by Fourier transform infrared and proton nuclear magnetic resonance...
September 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28891194/suspended-graphene-oxide-nanoparticle-for-accelerated-multilayer-osteoblast-attachment
#7
Tahereh Foroutan, Negin Nazemi, Mohadeseh Tavana, Mohammad Zaman Kassaee, Elaheh Motamedi, Shima Soieshargh, Hadi Zare Zardini
Mimicking bone tissues having layered structures is still a significant challenge because of the lack of technologies to assemble osteoblast cell types into bone structures. One of the promising and attractive materials in biomedical and different engineering fields is graphene and graphene-based nanostructures such as graphene oxide (GO) because of their unique properties. In most studies, GO was synthesized using chemical vapor deposition (CDV) method, and was coated on the substrate. In this study, we proposed a simple technique for assembly of cells that facilitates the construction of osteoblast -like structures using suspended GO synthesized by graphite powder, H2SO4, and KMnO4...
September 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28891111/construction-of-polylysine-dendrimer-nanocomposites-carrying-nattokinase-and-their-application-in-thrombolysis
#8
Can Wu, Chunmei Gao, Shaoyu Lü, Xiubin Xu, Na Wen, Shaofei Zhang, Mingzhu Liu
Thrombotic disease has become one of the leading causes of mortality among humans globally. Nattokinase (NK), a novel thrombolytic agent, has attracted the attention of researchers. However, NK is a serine protease that is vulnerable to environmental effects resulting in its inactivation. In this study, polylysine dendrimer (PLLD) was synthesized via divergence-convergence method, and a series of NK/PLLD nanocomposites with different molar ratio was prepared. In addition, NK was successfully incorporated into the cores of PLLD G4 through hydrogen bonds and van der Waals forces...
September 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28884523/response-of-umbilical-cord-mesenchymal-stromal-cells-to-varying-titanium-topographical-signals
#9
Ines Lauria, Miriam Höner, Sebastian Kant, Roswitha Davtalab, Thomas Weik, Katrin Sternberg, Horst Fischer
A wide variety of titanium implant modifications have been developed to improve tissue- or cell-material interactions including bone bonding, implant failure, and contact osteogenesis. Osteogenesis can be stimulated by mechanobiological signals such as topography though translation of in vivo reactions to in vitro bioactivity and stem cell culture data, and vice versa, is challenging. We hypothesized that a systematic in vitro approach comparing clinically well-accepted implant surface topographical modifications could shed light on potential cell biological mechanisms provoked by submicron-, micron- or macrostructured surfaces...
September 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28884519/gelatin-methacrylate-scaffold-for-bone-tissue-engineering-the-influence-of-polymer-concentration
#10
Nehar Celikkin, Simone Mastrogiacomo, Jakub Jaroszewicz, X Frank Walboomers, Wojciech Swieszkowski
Gelatin Methacrylate (GelMA) is an inexpensive, photocrosslinkable, cell-responsive hydrogel which has drawn attention for a wide range of tissue engineering applications. The potential of GelMA scaffolds was demonstrated to be tunable for different TE applications through modifying the polymer concentration, methacrylation degree or UV light intensity. Despite the promising results of GelMA hydrogels in tissue engineering, the influence of polymer concentration for bone tissue engineering scaffolds was not established yet...
September 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28884517/biocompatibility-assessment-of-titanium-dioxide-nanoparticles-in-mice-feto-placental-unit
#11
Parvaneh Naserzadeh, Fatemeh Ghanbary, Parviz Ashtari, Enayatollah Seydi, Khadijeh Ashtari, Mohsen Akbari
As the applications of titanium dioxide nanomaterials (nTiO2 ) are growing with an ever-increasing speed, the hazardous risks of this material have become a major concern. Several recent studies have reported that nTiO2 can cross the placental barrier in pregnant mice and cause neurotoxicity in their offspring. However, the influence of these nanoparticles on the fetoplacental unit during the pregnancy is yet to be studied. The present study reports on the effects of nTiO2 on the anatomical structure of fetal brain and liver in a pregnant mice model...
September 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28884512/bone-healing-capacity-of-conditioned-medium-derived-from-three-dimensionally-cultivated-human-mesenchymal-stem-cells-and-electrical-stimulation-on-collagen-sponge
#12
Soon Jung Hwang, Tae Hyung Cho, Beaomseok Lee, In Sook Kim
Continuing from our previous study, we hypothesized that combining electrical stimulation (ES) and three-dimensional (3D) culture would be a useful strategy to obtain more bioactive factors in conditioned medium (CM) derived from human mesenchymal stem cells (hMSC). Our aim in this study was to investigate the bone-healing capacity of CM derived from hMSC after 4 days of culture on a collagen sponge-exposed (CM-ES) or unexposed (CM-control; CM-CON) to ES in comparison with that of hMSC implantation. A cytokine assay of both CMs revealed the presence of cytokines, growth factors and trophic factors...
September 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28884509/evaluation-of-osteogenic-inductivity-of-a-novel-bmp2-mimicking-peptide-p28-and-p28-containing-bone-composite
#13
Tingfang Sun, Yanzhen Qu, Wei Cui, Liang Yang, Yanhui Ji, Wei Yu, Ramphul Navinduth, Zengwu Shao, Hu Yang, Xiaodong Guo
We developed a novel BMP2-mimicking peptide P28, which possess two distinct special structural elements-seven repetitive aspartic acids and phosphorylated serine designed to promote affinity to hydroxyapatite as well as nucleation of apatite crystallization and mineralization. In this work, we systematically studied the osteogenic inductivity of P28 in vivo and in vitro in comparison to BMP2. We confirmed its effects on proliferation, recruitment, and osteogenic differentiation of MC3T3-E1 cells in vitro. Furthermore, we loaded P28 into a biomimetic bone composite nano-hydroxyapatite/collagen/poly (L-lactide) (nHAC/PLA) and evaluated its ability to promote bone regeneration in vivo using a rabbit femoral condyle defect model...
September 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28884508/the-unique-calcium-chelation-property-of-poly-vinyl-phosphonic-acid-co-acrylic-acid-and-effects-on-osteogenesis-in-vitro
#14
Qiguang Wang, Ian Wimpenny, Rebecca E Dey, Xia Zhong, Peter J Youle, Sandra Downes, David C Watts, Peter M Budd, Judith A Hoyland, Julie E Gough
There is a clear clinical need for a bioactive bone graft substitute. Poly(vinyl phosphonic acid-co-acrylic acid) (PVPA-co-AA) has been identified as a promising candidate for bone regeneration but there is little evidence to show its direct osteogenic effect on progenitor or mature cells. In this study mature osteoblast-like cells (SaOS-2) and human bone marrow-derived mesenchymal stem cells (hBM-MSCs) were cultured with PVPA-co-AA polymers with different VPA:AA ratio and at different concentrations in vitro...
September 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28884507/extracellular-matrix-derived-from-periodontal-ligament-cells-maintains-their-stemness-and-enhances-redifferentiation-via-the-wnt-pathway
#15
Ji-Chun Zhang, Zhong-Chen Song, Yi-Ru Xia, Rong Shu
Large numbers of viable cells cannot be obtained from periodontal ligament tissues of patients with periodontitis. Therefore, it is imperative to establish an ex vivo environment that can support cell proliferation and delay senescence. Here, we have successfully reconstructed a native extracellular matrix (ECM), derived from early-passage human periodontal ligament cells (PDLCs) using the NH4 OH/Triton X-100 protocol. The ECM was investigated by scanning electron microscopy and immunostaining for specific ECM proteins (collagen I and fibronectin)...
September 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28884506/evaluation-of-a-series-of-silk-fibroin-protein-based-nonwoven-mats-for-use-as-an-anti-adhesion-patch-for-wound-management-in-robotic-surgery
#16
Yu-Chi Wang, Meng-Yi Bai, Wan-Yuan Hsu, Mu-Hsien Yu
A novel anti-adhesion nonwoven mat mainly composed of silk fibroin protein (SFP) was fabricated via the single-spinneret electrospinning technique. A series of SFP-based electrospun nonwoven mats containing additives of different synthetic polymer ratios, such as pure SFP, SFP/poly(vinyl alcohol) (PVA), SFP/polyethylene glycol (PEG), and SFP/polyethylene oxide (PEO) were produced and compared. All membranes were porous and had diameters of 324.02 ± 113.7, 308.86 ± 74.02, 366.22 ± 115.81, and 341...
September 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28884502/fabrication-of-tough-poly-ethylene-glycol-collagen-double-network-hydrogels-for-tissue-engineering
#17
Jing-Xiao Chen, Jing Yuan, Ya-Ling Wu, Ping Wang, Peng Zhao, Guo-Zhong Lv, Jing-Hua Chen
In this study, a series of PEG/Col double network (DN) hydrogel is fabricated from poly(ethylene glycol) (PEG) and collagen (Col). Results of the compressive strength test indicate that the strength and toughness of these DN hydrogels are significantly enhanced. The fracture strength of PEG/Col DN hydrogels increases by 9- to 12-fold compared with that of PEG single network (SN) hydrogel, and by 36- to 48-fold compared with that of Col SN hydrogel. Taking advantage of both PEG and Col building blocks, the PEG/Col DN hydrogels possess a strengthened skeleton...
September 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28884494/multilayered-pore-closed-plga-microsphere-delivering-ogp-and-bmp-2-in-sequential-release-patterns-for-the-facilitation-of-bmscs-osteogenic-differentiation
#18
Bing-Jun Zhang, Zhi-Wei Han, Ke Duan, Yan-Dong Mu, Jie Weng
Bone tissue regeneration may be more effectively administrated by controlled release of multiple biofactors, given that bone healing comprises a cascade of biological events controlled by numerous cytokines and growth factors (GFs). Here, we propose a novel microcarrier with the capability to sequentially deliver dual biofactors for better controlling the bone regeneration process. Firstly, osteogenic growth peptide (OGP) was incorporated in porous poly (lactic-co-glycolic) acid (PLGA) microspheres by a simple solution dipping method and subsequent pore-closing treatment...
September 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28884492/patterned-semiconductor-structures-modulate-neuronal-outgrowth-implication-for-the-development-of-a-neuro-bionic-interface
#19
Johannes Völker, Fabian Kohm, Lukas Jürgens, Agmal Scherzad, Philipp Schendzielorz, Sebastian Schraven, Robert Mlynski, Andreas Radeloff, Rudolf Hagen, Kristen Rak
Auditory implants stimulate the neurons by broad electrical fields, which leads to a low number of spectral channels. A reduction in the distance between the electrode and the neuronal structures might lead to better electrical transduction. The use of microstructured semiconductors offers a large number of contacts, which could attract neurons and stimulate them individually. To investigate the interaction between neurons and semiconductors, differentiated neuronal precursor cells were cultured on silicon wafers...
September 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28884489/voltage-and-wear-debris-from-ti-6al-4v-interact-to-affect-cell-viability-during-in-vitro-fretting-corrosion
#20
Tiantian Hui, Gregory W Kubacki, Jeremy L Gilbert
Fretting corrosion (or mechanically assisted corrosion, MAC) is a major corrosion mechanism in modular orthopedic implants. There is a complex interplay between fretting corrosion and the surrounding biological environment that includes particle generation and electrochemical potential excursions and currents. The goal of this work is to directly investigate the effects of fretting on cells in vitro. Using an in vitro fretting device, MC3T3 preosteoblasts were cultured onto Ti-6Al-4V disks adjacent to the fretting site...
September 7, 2017: Journal of Biomedical Materials Research. Part A
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