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Journal of Biomedical Materials Research. Part A

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https://www.readbyqxmd.com/read/30650243/aptamer-integrated-%C3%AE-gal-liposomes-as-bispecific-agents-to-trigger-immune-response-for-killing-tumor-cells
#1
Shanni Hong, Pi Ding, Yu Luo, Tian Gao, Ye Zhang, Renjun Pei
A novel bispecific α-Gal liposome was constructed by self-assembling AS1411 aptamers into the α-Gal containing liposomes. The α-Gal liposomes were prepared using cell membranes of red blood cells from rabbit, which are composed of cholesterol, phospholipids, and α-Gal glycolipids. AS1411 is a DNA aptamer with high specificity and affinity for nucleolin and could integrate into liposomes by the modification of cholesterol. The bispecific α-Gal liposomes surface-functionalized by α-Gal and AS1411 aptamer could recognize anti-Gal antibodies and nucleolin overexpressed by tumor cells simultaneously, followed by activating the immune system to attack the tumor cells, resulting in the lysis of the tumor cells by antibody dependent cell-mediated cytotoxicity...
January 16, 2019: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30650242/engineered-ph-responsive-hydrazone-carboxylate-complexes-encapsulated-2d-matrices-for-cathepsin-mediated-apoptosis-in-cancer
#2
Chen-Guang Liu, Ranjith Kumar Kankala, Hong-Yue Liao, Ai-Zheng Chen, Shi-Bin Wang
Spurred by the current advancements in engineering various intelligent nanoparticle-based drug delivery systems, conjugation of drugs with the stimuli-responsive molecular switches has become one of the most efficient approaches to deliver a drug cargo in spatiotemporal controlled fashions. In this study, we fabricated an innovative pH-triggered Hydrazone-carboxylate complex of doxorubicin (Dox), which was subsequently encapsulated in the layered double hydroxide (LDH) nanoparticles for effective cancer therapeutics...
January 16, 2019: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30650239/combination-of-bioactive-factors-and-ieik13-self-assembling-peptide-hydrogel-promotes-cartilage-matrix-production-by-human-nasal-chondrocytes
#3
Alexandre Dufour, Marie Buffier, Delphine Vertu-Ciolino, François Disant, Frédéric Mallein-Gerin, Emeline Perrier-Groult
Nasal reconstruction remains a challenge for every reconstructive surgeon. Alloplastic implants are proposed to repair nasal cartilaginous defects but they are often associated with high rates of extrusion and infection and poor biocompatibility. In this context, a porous polymeric scaffold filled with an autologous cartilage gel would be advantageous. In this study, we evaluated the capacity of IEIK13 self-assembling peptide to serve as support to form such cartilage gel. Human nasal chondrocytes (HNC) were first amplified with FGF-2 and insulin, then re-differentiated in IEIK13 with BMP-2, Insulin and T3 (BIT)...
January 16, 2019: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30650226/preparation-of-thermo-redox-ph-stimulative-poly-n-isopropylacryamide-co-n-n-dimethylaminoethyl-methacrylate-nanogels-and-their-dox-release-behaviors
#4
Doudou Gao, Lanlan Duan, Meng Wu, Xianxun Wang, Zhengguang Sun, Yuhong Zhang, Yulin Li, Peixin He
Stimuli-sensitive drug delivery systems show beneficial features of both medical and pharmaceutical fields. In this paper, polymeric nanogel P (NIPAM-DMAEMA) (PND) with pH/redox/thermo-responsivenesses was synthesized by in situ polymerization of N-isopropylacryamide (NIPAM), N, N'-dimethylaminoethyl methacrylate (DMAEMA) for controlled release of doxorubicin hydrochloride (DOX). N, N'-bis (acryloyl) cystamine (BAC) and N, N'-methylene bisacrylamide (MBA) as the crosslinker, respectively. The structure, size and Zeta potential of PND-BAC and PND-MBA were further characterized...
January 16, 2019: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30636094/poly-3-hydroxybutyrate-co-3-hydroxyvalerate-fibrinogen-bredigite-nanofibrous-membranes-and-their-integration-with-osteoblasts-for-guided-bone-regeneration
#5
Monireh Kouhi, Venugopal Jayarama Reddy, Mohammadhossein Fathi, Morteza Shamanian, Afsaneh Valipouri, Seeram Ramakrishna
Guided bone regeneration (GBR) has been established to be an effective method for the repair of defective tissues, which is based on isolating bone defects with a barrier membrane for faster tissue reconstruction. The aim of the present study is to develop poly (hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/fibrinogen (FG)/bredigite (BR) membranes with applicability in GBR. BR nanoparticles were synthesized through a sol-gel method and characterized using transmission electron microscopy (TEM) and X-ray diffractometer (XRD)...
January 12, 2019: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30636089/in-vitro-interaction-of-human-wharton-s-jelly-mesenchymal-stem-cells-with-biomimetic-3-d-scaffold
#6
Zahra Jamalpoor, Nafise Taromi, Mansooreh Soleimani, Masoumeh Foroutan Koudehi, Alireza Asgari
Study of cell-biomaterial interaction is a crucial aspect of bone tissue engineering to find a state-of-the-art functional substitute. In present study, the Wharton's jelly mesenchymal stem cells (hWJ-MSCs) behavior on 3-D biomimetic nano-hydroxy apatite/ chitosan/gelatin (nHA/CS/Gel) scaffolds was investigated. The outcome was assessed by histological, biochemical and morphological tests. Results indicated that hWJ-MSCs attached onto the scaffold surface through membrane filopodia, uniformly spread throughout the contacting surface...
January 12, 2019: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30635968/two-dimensional-graphene-oxide-reinforced-porous-biodegradable-polymeric-nanocomposites-for-bone-tissue-engineering
#7
Behzad Farshid, Gaurav Lalwani, Meisam Shir Mohammadi, Jeyantt Srinivas Sankaran, Sunny Patel, Stefan Judex, John Simonsen, Balaji Sitharaman
This study investigates the mechanical properties and in-vitro cytotoxicity of two-dimensional (2D) graphene oxide nanoribbons and nanoplatelets (GONRs and GONPs) reinforced porous polymeric nanocomposites. Highly porous poly(propylene fumarate) (PPF) nanocomposites were prepared by dispersing 0.2 wt.% single- and multi-walled graphene oxide nanoribbons (SWGONRs and MWGONRs) and graphene oxide nanoplatelets (GONPs). The mechanical properties of scaffolds were characterized using compression testing and in vitro cytocompatibility was assessed using Quantiflour™ assay for cellularity and presto blue™ assay for cell viability...
January 11, 2019: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30615257/polymer-scaffold-architecture-is-a-key-determinant-in-mast-cell-inflammatory-and-angiogenic-responses
#8
Daniel Abebayehu, Andrew J Spence, Michael J McClure, Tamara T Haque, Kevin O Rivera, John J Ryan
Implanted polymer scaffolds can induce inflammation leading to the foreign body response (FBR), fibrosis, and implant failure. Thus, it is important to understand how immune cells interact with scaffolds to mitigate inflammation and promote a regenerative response. We previously demonstrated that macrophage phenotype is modulated by fiber and pore diameters of an electrospun scaffold. However, it is unclear if this effect is consistent among other innate immune cells. Mast cells are inflammatory sentinels that play a vital role in the FBR of implanted biomaterials, as well as angiogenesis...
January 7, 2019: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30615255/peptide-modified-hyaluronic-acid-based-hydrogels-as-a-3d-culture-platform-for-neural-stem-progenitor-cell-engineering
#9
Stephanie K Seidlits, Jesse Liang, Rebecca D Bierman, Alireza Sohrabi, Joshua Karam, Sandra M Holley, Carlos Cepeda, Christopher M Walthers
Neural stem/progenitor cell (NS/PC)-based therapies have shown exciting potential for regeneration of the central nervous system (CNS) and NS/PC cultures represent an important resource for disease modeling and drug screening. However, significant challenges limiting clinical translation remain, such as generating large numbers of cells required for model cultures or transplantation, maintaining physiologically representative phenotypes ex vivo and directing NS/PC differentiation into specific fates. Here, we report that culture of human NS/PCs in 3D, hyaluronic acid (HA)-rich biomaterial microenvironments increased differentiation towards oligodendrocytes and neurons over 2D cultures on laminin-coated glass...
January 7, 2019: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30615252/multiple-shape-memory-behavior-of-highly-oriented-long-chain-branched-poly-lactic-acid-and-its-recovery-mechanism
#10
Jiafeng Li, Xiaowen Zhao, Lin Ye, Phil Coates, Fin Caton-Rose
The shape memory effect of highly oriented long-chain-branched Poly(lactic acid) (LCB-PLA) prepared through solid-phase die drawing technology was studied by comparison with PLA. When the recovery temperature increased form 60 o C to 120 o C, for PLA, only one-step recovery at about 80o C can be observed and the recovery ratio was below 21.5%, while, for LCB-PLA, multiple recovery behavior with high recovery ratio of 78.8% can be achieved. For oriented PLA, the recovery curve of the final sample showed the same trend with that of sample suffering just free drawing; while for oriented LCB-PLA, the recovery curve of the final sample showed the same trend with that of sample suffering just die drawing...
January 7, 2019: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30597736/the-dental-monomer-hema-causes-proteome-changes-in-human-thp-1-monocytes
#11
Jan Tore Samuelsen, Vibeke Barman Michelsen, Jack-Ansgar Bruun, Jon E Dahl, Einar Jensen, Ulf Örtengren
Resin-based biomaterials are widely used in medical and dental treatment, and both clinicians and patients are exposed to the materials. The knowledge of toxicity is mainly based on in vitro studies at exposure concentrations that induce cell death. However, severe cell damage and cell-death signaling may overshadow essential cellular events caused by a possible toxicant. For dental resins, the knowledge of interaction with living cells at more clinical relevant exposure doses is sparse. 2-Hydroxyethylmethacrylate (HEMA) is a commonly used monomer in dental resins...
December 30, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30597732/functional-surfaces-for-efficient-differentiation-of-neural-stem-progenitor-cells-into-dopaminergic-neurons
#12
Tadashi Nakaji-Hirabayashi, Kurumi Fujimoto, Chiaki Yoshikawa, Hiromi Kitano
Various techniques and systems have been reported for the efficient differentiation of neural stem/progenitor cells into dopaminergic neurons. Although a comparatively high percentage of dopaminergic neurons can be obtained using these techniques, the differentiated cells display varied cellular phenotypes such as astrocytes and oligodendrocytes. Generation of highly pure dopaminergic neurons is important for cell-based therapy and in vitro evaluation of dopaminergic neuron function. In this study, we developed a culture surface anchored with several neurotrophic factors and a neuronal cell-adhesive protein for efficient differentiation of neural stem/progenitor cells into dopaminergic neurons...
December 30, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30597721/tegdma-releasing-in-resin-composites-with-different-filler-contents-and-its-correlation-with-mitochondrial-mediated-cytotoxicity-in-human-gingival-fibroblasts
#13
Beilei Liu, Xueqi Gan, Yuwei Zhao, Junsheng Chen, Hongdou Yu, Jing Gao, Haiyang Yu
Compositions of resin composite exhibit cytotoxicity, especially Triethylene-glycol-dimethacrylate (TEGDMA), yet the underlying mechanisms and its relationship with filler content are poorly understood. Here, specimens of 5 composites (VITA LC, VITA ZETA, Z350, Filtek P60 and AP-X), containing different filler size and weight, were immersed into culture medium for 72 h. After TEGDMA quantification, the resin composite eluates were used to incubate human gingival fibroblasts (HGFs). Cellular viability was evaluated...
December 30, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30586231/polyelectrolyte-membrane-scaffold-sustains-growth-of-neuronal-cells
#14
A Grzeczkowicz, J Gruszczynska-Biegala, M Czeredys, A Kwiatkowska, M Strawski, M Szklarczyk, M Koźbiał, J Kuźnicki, L H Granicka
Cell immobilization within nano-thin polymeric shells can provide an optimal concentration of biological material in a defined space and facilitate its directional growth. Herein, polyelectrolyte membrane scaffolds were constructed using a layer-by-layer approach to determine the possibility of promoting improved growth of rat cortical neuronal cells. Membrane presence was confirmed by Fourier transform infrared spectroscopy, Zeta potential, and atomic force and scanning electron microscopy. Scaffold performance towards neuronal cell growth was assessed in vitro during a 14-day culture...
December 26, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30578722/in-vitro-evaluation-of-electrospun-blends-of-gelatin-and-pcl-for-application-as-a-partial-thickness-corneal-graft
#15
J B Rose, L E Sidney, J Patient, L J White, H S Dua, A J El Haj, A Hopkinson, F R A J Rose
The advent of innovative surgical procedures utilizing partial thickness corneal grafts has created a need for the development of synthetic implants to recreate corneal stromal tissue. This work evaluates electrospun gelatin and polycaprolactone (PCL) scaffolds as a potential biomaterial suitable for use in regeneration of corneal stromal tissue. Electrospun gelatin has been used for many years in tissue engineering, however, post-production modification, such as crosslinking, is usually required to mechanically strengthen such scaffolds...
December 22, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30578719/mechanical-loading-induced-osteocyte-apoptosis-and-connexin-43-expression-in-three-dimensional-cell-culture-and-dental-implant-model
#16
Yoko Takemura, Yasuko Moriyama, Yasunori Ayukawa, Kosaku Kurata, Yunia D Rakhmatia, Kiyoshi Koyano
Osteocytes are thought to act as stress sensors, and are known to display a gap junction-mediated stress-transfer mechanism. To demonstrate the stress-related function of osteocytes, cells of an osteocyte-like cell line derived from murine long bone osteocyte Y4 (MLO-Y4) were cultivated in a three-dimensional culture and subjected to cyclic loading from a titanium plate. This application of physiological loading using a titanium plate significantly increased connexin 43 (Cx43) expression, the number of dead and apoptotic cells, and receptor activator of nuclear factor κB ligand expression...
December 22, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30578713/preparation-of-fibrin-gel-scaffolds-containing-mwcnt-pu-nanofibers-for-neural-tissue-engineering
#17
Elham Hasanzadeh, Somayeh Ebrahimi-Barough, Esmaeil Mirzaei, Mahmoud Azami, Seyed Mohammad Tavangar, Narges Mahmoodi, Arefe Basiri, Jafar Ai
Compared to the peripheral nervous system (PNS), in the central nervous system (CNS) disorders, neurons are less able to regenerate and reconstruct the neural tissue. Tissue engineering is considered as a promising approach for neural regeneration and restoring neurologic function after CNS injuries. Nanofibrous hydrogels have been recently used as three-dimensional (3D) scaffolds for tissue engineering applications. In this kind of composites, hydrogels are incorporated with fibers to enhance their poor mechanical properties...
December 22, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30575268/silica-polycaprolactone-nanofiber-scaffold-variants-for-human-periosteal-cell-growth
#18
Christopher W Burton, Robin DiFeo Childs, Phillip McClellan, Qing Yu, Joshua Bundy, Min Gao, Edward Evans, William Landis
Polycaprolactone (PCL) nanofiber scaffolds with attached cadaveric human periosteum or its cells were investigated in this study as a tissue-engineering approach to repair non-union injuries of bone. Addition of silica nanoparticles (silica or nSiO2 ) to PCL scaffolds was examined for effects on the growth of human periosteal cells in vitro and in vivo. Electrospun PCL nanofiber (nanoPCL) scaffolds were fabricated with different silica content (0, 0.5 and 1.0 wt%) and utilized as substrates on which periosteal cells were seeded...
December 21, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30549210/biomaterial-induced-multinucleated-giant-cells-express-proinflammatory-signaling-molecules-a-histological-study-in-humans
#19
Yunxin Zhang, Sarah Al-Maawi, Xuejiu Wang, Robert Sader, C James Kirkpatrick, Shahram Ghanaati
The biomaterials physicochemical characteristics influence their cellular reaction, degradation and regenerative capacities. Macrophages and multinucleated giant cells (MNGCs) are observed in the augmentation area of biomaterials. This study, for the first time, evaluated the polarization pattern of macrophages and MNGCs in response to two different bone substitute materials (synthetic bone substitute material (SBSM) = NanoBone® vs. xenogeneic bone substitute material (XBSM) = Bio-Oss®) in human bone biopsies compared to non-augmented bone (control)...
December 13, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/30549187/the-interaction-of-chitosan-and-bmp-2-tuned-by-deacetylation-degree-and-ph-value
#20
Qun Wang, Menghao Wang, Pengfei Li, Kefeng Wang, Liming Fang, Fuzeng Ren, Guoming Lu, Xiong Lu
Integrating proteins with chitosan (CS) can not only improve the biocompatibility of CS, but also enable the sustained release of proteins. The deacetylation degree (DD) and pH conditions are considered as the two most important factors affecting the interaction between CS and proteins. In this study, the effects of CS with different DDs and pH conditions on bone morphogenetic protein-2 (BMP-2) adsorption were evaluated using the molecular dynamics (MD) method. The results showed that the interaction energy first increased and then decreased, with the increase of the DD in the range of 0% to 100%; the strongest interaction was found between BMP-2 and 75% DD-CS surface...
December 13, 2018: Journal of Biomedical Materials Research. Part A
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