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Journal of Biomedical Materials Research. Part A

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https://www.readbyqxmd.com/read/28445626/fabrication-and-characterization-of-chitosan-polyvinylpyrrolidone-and-cellulose-nanowhiskers-nanocomposite-films-for-wound-healing-drug-delivery-application
#1
Abshar Hasan, Gyan Waibhaw, Sakshi Tiwari, K Dharmalingam, I Shukla, Lalit M Pandey
This study describes the preparation of composite film using chitosan (CS) and polyvinylpyrrolidone (PVP) with incorporated cellulose nanowhiskers (CNWs) for drug delivery application. CNWs were prepared by acid hydrolysis of cellulose with sulfuric acid. Field emission scanning electron microscopy studies revealed nanofibrous morphology of CNWs with 20-30 nm diameter and 200-250 nm in length. X-ray powder diffraction (XRD) analysis confirmed highly crystalline nature of CNWs with 92.81% crystallinity. Incorporation of CNWs enhanced the thermal and mechanical properties of films...
April 26, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28445607/fractal-characteristics-of-the-microvascular-network-a-useful-index-to-assess-vascularization-level-of-porous-silk-fibroin-biomaterial
#2
Kuihua Zhan, Lun Bai, Qinqin Wu, Derong Lei, Guangqian Wang
The neovascularization of biomaterials for tissue engineering is not only related to growth of capillaries but also involves appropriate hierarchy distribution of the microvessels. In this study, we proposed hierarchy distribution contrast method which can assess vascular transport capacity, in order to examine the hierarchy distribution of the neovessels during vascularization of the porous silk fibroin biomaterials implanted into rats and its evolution. The results showed that the fractal characteristics appeared toward the end of the vascularization stages, and the structure of the microvascular network after 3 weeks of implantation was similar to the fractal microvascular tree with bifurcation exponent x=3 and fractal dimension D=1...
April 26, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28445606/structural-and-biological-properties-of-thermosensitive-chitosan-graphene-hybrid-hydrogels-for-sustained-drug-delivery-applications
#3
Leyla Saeednia, Li Yao, Marcus Berndt, Kim Cluff, Ramazan Asmatulu
Chitosan has the ability to make injectable thermosensitive hydrogels which has been highly investigated for drug delivery applications. The addition of nanoparticles is one way to increase the mechanical strength of thermosensitive chitosan hydrogel and subsequently and control the burst release of drug. Graphene nanoparticles have shown unique mechanical, optical and electrical properties which can be exploited for biomedical applications, especially in drug delivery. This study, have focused on the mechanical properties of a thermosensitive and injectable hybrid chitosan hydrogel incorporated with graphene nanoparticles...
April 26, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28445604/investigating-the-effect-of-fibulin-1-on-the-differentiation-of-human-nasal-inferior-turbinate-derived-mesenchymal-stem-cells-into-osteoblasts
#4
Le B Hang Pham, Yie-Ri Yoo, Sun Hwa Park, Sang A Back, Sung Won Kim, Isabel Bjørge, Jun-Hyeog Jang
Many extracellular matrix proteins have positive influences on the adhesion, proliferation and differentiation of stem cells into specific cell linages. Fibulin-1 (FBLN1), a member of a growing family of extracellular glycoproteins, contributes to the structure of the extracellular matrix. Here, we investigated the effect of FBLN1 on the ability of human nasal inferior turbinate-derived mesenchymal stem cells (hTMSCs) to undergo osteogenic differentiation. After we generated recombinant FBLN1, the characteristics of FBLN1-treated hTMSCs were evaluated using MTT assay, ALP and mineralization activities, and quantitative real-time PCR...
April 26, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28426904/in-vitro-study-of-the-proliferation-and-growth-of-human-fetal-osteoblasts-on-mg-and-si-co-substituted-tricalcium-phosphate-ceramics
#5
Juan Parra, Ismael H García Páez, Antonio H De Aza, Carmen Baudin, M Rocío Martín, Pilar Pena
The objective of this work was to study the feasibility of the solid state sintering, a conventional ceramic processing method, to obtain Mg and Si co-substituted tricalcium phosphate bioceramics and composites containing diopside. A series of new Ca3 (PO4 )2 based ceramics has been prepared from attrition milled mixtures of synthetic Ca3 (PO4 )2 and CaMg(SiO3 )2 powders, isostatically pressed and sintered at 1250-1300°C. Materials containing 0, 1 and 5 wt.% of CaMg(SiO3 )2 were constituted by β + α - Ca3 (PO4 )2 solid solutions while the material containing 60 wt...
April 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28426898/improving-myoblast-differentiation-on-electrospun-poly-%C3%AE%C2%B5-caprolactone-scaffolds
#6
Phammela N Abarzúa-Illanes, Cristina Padilla, Andrea Ramos, Mauricio Isaacs, Jorge Ramos-Grez, Hugo C Olguín, Loreto M Valenzuela
Polymer scaffolds are used as an alternative to support tissue regeneration when it does not occur on its own. Cell response on polymer scaffolds is determined by factors such as polymer composition, topology, and the presence of other molecules. We evaluated the cellular response of murine skeletal muscle myoblasts on aligned or unaligned fibers obtained by electrospinning poly(ε-caprolactone) (PCL), and blends with poly(lactic-co-glycolic acid) (PLGA) or decorin, a proteoglycan known to regulate myogenesis...
April 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28426158/a-novel-technique-for-decellularization-of-allogenic-nerves-and-in-vivo-study-of-their-use-for-peripheral-nerve-reconstruction
#7
F Boriani, N Fazio, C Fotia, L Savarino, N Nicoli Aldini, L Martini, N Zini, M Bernardini, N Baldini
Autografts represent the gold standard for peripheral nerve reconstruction but their limited availability, the discrepancy of nerve caliber and long surgical times are drawbacks. Allografts have therefore become a valid alternative option. In particular, acellular nerve allografts (ANAs) rather than fresh allografts do not need immunosuppression and appear to be safe and effective based on recent studies. An innovative method was conceived to obtain ANAs, so as to speed up nerve decellularization, without compromising nerve architecture, and without breaking the asepsis chain...
April 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28419760/bone-marrow-derived-stem-stromal-cells-and-adipose-tissue-derived-stem-stromal-cells-their-comparative-efficacies-and-synergistic-effects
#8
REVIEW
Gun-Il Im
Mesenchymal stem cells (MSCs) are heterogeneous cell populations that serve as reserves for tissue regeneration in the presence of disease or injury. Although MSCs are found in various tissues, bone marrow-derived stem/stromal cells (BMSCs) and adipose tissue-derived stem/stromal cells (ADSCs) have been most thoroughly investigated. Furthermore, ADSCs have recently emerged as an attractive source of MSCs due to their abundance and availability. BMSCs and ADSCs demonstrate similar morphological characteristics, but their in vitro characteristics and differentiation abilities appear to differ...
April 17, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28395127/site-specific-gene-expression-analysis-of-implant-near-cells-in-a-soft-tissue-infection-model-application-of-laser-microdissection-to-study-biomaterial-associated-infection
#9
Sara Svensson, Margarita Trobos, Omar Omar, Peter Thomsen
Analysis of the implant-tissue interface is important for an understanding of the cellular response to biomaterials with different surface characteristics. However, inaccessibility to the site has restricted the detailed evaluation of the tissue surrounding the implant. Laser microdissection enables the isolation of specific cells and tissues for subsequent DNA, RNA or protein analysis. The present experimental study employed laser microdissection to analyse tissue-specific differences in gene expression in cells around infected or control titanium implants 72 hours after subcutaneous implantation in a rat model...
April 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28387995/recent-strategies-in-cartilage-repair-a-systemic-review-of-the-scaffold-development-and-tissue-engineering
#10
REVIEW
Vikrant Rai, Matthew F Dilisio, Nicholas E Dietz, Devendra K Agrawal
Osteoarthritis results in irreparable loss of articular cartilage. Due to its avascular nature and low mitotic activity, cartilage has little intrinsic capacity for repair. Cartilage loss leads to pain, physical disability, movement restriction, and morbidity. Various treatment strategies have been proposed for cartilage regeneration, but the optimum treatment is yet to be defined. Tissue engineering with engineered constructs aimed towards developing a suitable substrate may help in cartilage regeneration by providing the mechanical, biological and chemical support to the cells...
April 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28380697/graphene-oxide-enrichment-collagen-membranes-improves-dpscs-differentiation-and-controls-inflammation-occurrence
#11
Milena Radunovic, Marianna De Colli, Patrizia De Marco, Chiara Di Nisio, Antonella Fontana, Adriano Piattelli, Amelia Cataldi, Susi Zara
Collagen membranes are used in oral surgery for bone defects treatment acting as a barrier that does not allow the invasion of soft tissue into the growing bone. To improve biocompatibility collagen membranes were coated with graphene oxide (GO), a graphene derivative. The aim of this study was to investigate the biocompatibility of GO coated collagen membranes on human dental pulp stem cells (DPSCs) focusing on biomaterial cytotoxicity, ability to promote DPSCs differentiation process and to control inflammation event induction...
April 5, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28380688/fabrication-and-characterization-of-a-decellularized-bovine-tendon-sheet-for-tendon-reconstruction
#12
Liang-Ju Ning, Yan-Lin Jiang, Cheng-Hao Zhang, Yi Zhang, Jie-Liang Yang, Jing Cui, Yan-Jing Zhang, Xuan Yao, Jing-Cong Luo, Ting-Wu Qin
Obtaining a performing decellularized tendon scaffold with proper dimensions and adequate availability is highly desirable. However, the combined study of complete decellularization and detailed characterization of native tendon extracellular matrix (ECM) from large animals is still lacking. In the present study, we developed a new decellularization protocol, including physical methods and enzymatic solutions for processing bovine Achilles tendons, and produced a decellularized bovine tendon sheet (DBTS) scaffold for tendon reconstruction...
April 5, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28380676/bactericidal-effect-of-photocatalytically-active-nanostructured-tio2-surfaces-on-biofilms-of-the-early-oral-colonizer-streptococcus-oralis
#13
Emma Westas, Mariko Hayashi, Francesca Cecchinato, Ann Wennerberg, Martin Andersson, Ryo Jimbo, Julia R Davies
This study evaluated the photocatalytic bactericidal effect of nanostructured anatase-rich titanium dioxide (TiO2 ) on biofilms. Commercially pure titanium discs were spin-coated with photocatalytic TiO2 nanoparticles (P25). Uncoated discs were used as control (CTRL). Half of the CTRL and half of the P25-coated surfaces were coated with purified saliva (SAL) to give four different groups (CTRL, CTRL+SAL, P25 and P25+SAL). Streptococcus oralis were allowed to form biofilms on the discs for 18 hours and non-adherent cells were rinsed off thereafter...
April 5, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28380671/bicomponent-fibrous-scaffolds-made-through-dual-source-dual-power-electrospinning-dual-delivery-of-rhbmp-2-and-ca-p-nanoparticles-and-enhanced-biological-performances
#14
Chong Wang, William Weijia Lu, Min Wang
Electrospun scaffolds incorporated with both calcium phosphates (Ca-P) and bone morphogenetic protein-2 (BMP-2) have been used for bone tissue regeneration. However, in most cases BMP-2 and Ca-P were simply mixed and loaded in a monolithic structure, risking low BMP-2 loading level, reduced BMP-2 biological activity, uncontrolled BMP-2 release and inhomogeneous Ca-P distribution. In this investigation, novel bicomponent scaffolds having evenly distributed rhBMP-2-containing fibers and Ca-P nanoparticle-containing fibers were made using an established dual-source dual-power electrospinning technique with the assistance of emulsion electrospinning and blend electrospinning...
April 5, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28380669/antibacterial-and-bioactive-coatings-on-titanium-implant-surfaces
#15
Anupama Kulkarni Aranya, Smruti Pushalkar, Minglei Zhao, Racquel Z LeGeros, Yu Zhang, Deepak Saxena
Various surface modifications have been tried for enhancing osseointegration of the dental implants like mechanical and/or chemical treatments and deposition of calcium phosphate coatings. The objective of this research was to develop calcium-phosphate based thin coatings with antibacterial and bioactive properties for potential application in dental implants. Titanium (Ti) discs were immersed in different calcifying solutions: CaP (positive control), F-CaP, Zn-CaP and FZn-CaP and incubated for 24 h. Negative control was uncoated Ti discs...
April 5, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28380658/cationic-osteogenic-peptide-p15-csp-coatings-promote-3-d-osteogenesis-in-poly-epsilon-caprolactone-scaffolds-of-distinct-pore-size
#16
Xian Li, Nima Ghavidel Mehr, Jessica Guzmán-Morales, Basil D Favis, Gregory De Crescenzo, Nanda Yakandawala, Caroline D Hoemann
P15-CSP is a biomimetic cationic fusion peptide that stimulates osteogenesis and inhibits bacterial biofilm formation when coated on 2-D surfaces. This study tested the hypothesis that P15-CSP coatings enhance 3-D osteogenesis in a porous but otherwise hydrophobic poly-(ε-caprolactone) (PCL) scaffold. Scaffolds of 84 µm and 141 µm average pore size were coated or not with Layer-by-Layer polyelectrolytes followed by P15-CSP, seeded with adult primary human mesenchymal stem cells (MSCs), and cultured 10 days in proliferation medium, then 21 days in osteogenic medium...
April 5, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28371194/graphene-as-multi-functional-delivery-platform-in-cancer-therapy
#17
REVIEW
Mojgan Nejabat, Fahimeh Charbgoo, Mohammad Ramezani
The biomedical applications of graphene-based nanomaterials including drug and gene delivery have grown rapidly in the past few years. This is due to its high surface area that results in high cargo loading capacity. It is demonstrated that graphene can improve drug efficacy without increasing the dose of the chemotherapeutic agent in cancer treatment. Considering these valuable benefits of graphene, this review focused on the newest advancements in drug and gene delivery systems using graphene and unveiling advantages and disadvantages of different graphene-based materials in introducing an effective cargo delivery system for cancer therapy...
April 3, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28371423/characterisation-of-sh-sy5y-human-neuroblastoma-cell-growth-over-glass-and-su-8-substrates
#18
A Ajetunmobi, D McAllister, Namrata Jain, Owen Brazil, A Corvin, Y Volkov, D Tropea, A Prina-Mello
The physical properties of substrates can have profound effects on the structure and function of cultured cells. In this study we aimed to examine the viability, adherence and morphological and functional variations between SH-SY5Y human neuroblastoma cells cultured on SU-8 surfaces compared to control surfaces composed of borosilicate glass, which are routinely used for cell culture. The SU-8 polymer has been extensively studied for its biocompatibility but there has been little investigation into the characteristic differences between cells cultured on SU-8 when compared to glass...
March 28, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28371333/behavior-of-prostate-cancer-cells-in-a-nanohydroxyapatite-collagen-bone-scaffold
#19
S Cruz-Neves, N Ribeiro, I Graça, C Jerónimo, S R Sousa, F J Monteiro
Prostate cancer (PCa) is the second leading cause of death among men in Europe and US. The metastatic dissemination pattern of PCa is unique, developing bone metastasis as the only site of progression, consequently with a prognosis very poor. The cancer cells interactions within the surrounding bone environment are critical for tumor growth and progression. SPARC (Secreted Protein, Acidic and Rich in Cysteine) is described to be involved in PCa cells migration and invasion into bone. 3D in vitro systems that are able to closely resemble the in vivo microenvironment are recently taking importance in cancer research...
March 28, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28371332/fluorinated-methacrylamide-chitosan-sequesters-reactive-oxygen-species-to-relieve-oxidative-stress-while-delivering-oxygen
#20
Pritam S Patil, Nic D Leipzig
Antioxidants play an important role in regulating overabundant reactive oxygen species (ROS) in wound healing to reduce oxidative stress and inflammation. In this work we demonstrate for the first time that functionalization of methacrylamide chitosan (MAC) with aliphatic pentadecafluoro chains, to synthesize pentadecafluoro-octanoyl methacrylamide chitosan (MACF), enhances the antioxidant capacity of the MAC base hydrogel material, while being able to deliver oxygen for future enhanced wound healing applications...
March 28, 2017: Journal of Biomedical Materials Research. Part A
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