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Diabetes & Vascular Disease Research

Isabelle Johansson, Ulf Dahlström, Magnus Edner, Per Näsman, Lars Rydén, Anna Norhammar
OBJECTIVE: To study the characteristics and prognostic implications of type 2 diabetes in different heart failure entities from a nationwide perspective. METHODS: This observational study comprised 30,696 heart failure patients prospectively included in the Swedish Heart Failure Registry (SwedeHF) 2003-2011 from specialist care, with mortality information available until December 2014. Patients were categorized into three heart failure entities by their left ventricular ejection fraction (heart failure with preserved ejection fraction: ⩾50%, heart failure with mid-range ejection fraction: 40%-49% and heart failure with reduced ejection fraction: <40%)...
September 3, 2018: Diabetes & Vascular Disease Research
Ramzi A Ajjan, Michael H Cummings, Peter Jennings, Lalantha Leelarathna, Gerry Rayman, Emma G Wilmot
Continuous glucose monitoring and flash glucose monitoring systems are increasingly used by people with diabetes on multiple daily injections of insulin and continuous subcutaneous insulin infusion. Along with real-time updates on current glucose levels, these technologies also use trend arrows to provide information on the direction and rate of change of glucose. Two systems, the Dexcom G5 and the FreeStyle Libre, have recently been approved for use without the need for adjunct capillary blood glucose, and there is a need for practical guidance for insulin dosing which incorporates rate of change in the insulin dosing algorithm...
September 3, 2018: Diabetes & Vascular Disease Research
Ja Young Jeon, Kyoung Hwa Ha, Seung Jin Han, Hae Jin Kim, Kwan-Woo Lee, Dae Jung Kim
INTRODUCTION: We examined whether circulating adiponectin levels are associated with further cardiovascular events in patients with type 2 diabetes. METHODS: Between December 2004 and February 2005, 349 patients with type 2 diabetes were enrolled and followed-up until December 2015. Blood levels of total, middle-molecular weight and high-molecular weight adiponectin were measured at baseline. The primary composite outcome was the occurrence of the following events: cardiovascular death, non-fatal myocardial infarction, non-fatal stroke or hospitalization for unstable angina and heart failure...
August 30, 2018: Diabetes & Vascular Disease Research
John Cl Mamo, Virginie Lam, Emily Brook, Armin Mooranian, Hani Al-Salami, Nicholas Fimognari, Michael Nesbit, Ryusuke Takechi
An emerging body of evidence consistently suggests that compromised blood-brain barrier integrity may be causally associated with cognitive decline induced by type-2 diabetes. Our previous studies demonstrated that selected anti-inflammatory/anti-oxidative agents can preserve the integrity of blood-brain barrier and prevent neuroinflammation in mouse models of dysfunctional blood-brain barrier. Therefore, we have tested whether the previously proven blood-brain barrier protective agent, probucol, can prevent blood-brain barrier breakdown and cognitive decline in a dietary-induced murine model of diabetic insulin resistance...
August 29, 2018: Diabetes & Vascular Disease Research
Francisco Javier Álvaro Afonso, Esther García-Morales, Raúl J Molines-Barroso, Yolanda García-Álvarez, Irene Sanz-Corbalán, José Luis Lázaro-Martínez
We respond to the letter of Nadery and Shahsavari regarding our paper entitled 'Interobserver reliability of the ankle brachial index, toe -brachial index and distal pulse palpation in patients with diabetes. In this letter, we concluded that despite some limitations, the kappa coefficient is an informative measure of agreement in most circumstances that we can use in this type of clinical research.
August 23, 2018: Diabetes & Vascular Disease Research
Azlina A Razak, Lopa Leach, Vera Ralevic
BACKGROUND: There is clinical and experimental evidence for altered adenosine signalling in the fetoplacental circulation in pregnancies complicated by diabetes, leading to adenosine accumulation in the placenta. However, the consequence for fetoplacental vasocontractility is unclear. This study examined contractility to adenosine of chorionic vessels from type 1 diabetes mellitus, gestational diabetes mellitus and normal pregnancies. METHODS: Chorionic arteries and veins were isolated from human placenta from normal, gestational diabetes mellitus and type 1 diabetes mellitus pregnancies...
August 22, 2018: Diabetes & Vascular Disease Research
Hadii M Mamudu, Arsham Alamian, Timir Paul, Pooja Subedi, Liang Wang, Antwan Jones, Ali E Alamin, David Stewart, Gerald Blackwell, Matthew Budoff
AIM: To examine the association of cardiovascular disease risk factors with and their cumulative effect on coronary artery calcium in hard-to-reach asymptomatic patients with diabetes. METHODS: A total of 2563 community-dwelling asymptomatic subjects from Central Appalachia participated in coronary artery calcium screening at a heart centre. Binary variable was used to indicate that coronary artery calcium was either present or absent. Independent variables consisted of demographic and modifiable risk factors and medical conditions...
August 16, 2018: Diabetes & Vascular Disease Research
Selma Bouthoorn, Gideon B Valstar, Aisha Gohar, Hester M den Ruijter, Hans B Reitsma, Arno W Hoes, Frans H Rutten
OBJECTIVE: Type 2 diabetes is a risk factor for the development of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction. Our aim was to provide a summary estimate of the prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in type 2 diabetes patients and to investigate sex disparities. METHODS AND RESULTS: A systematic search of the databases Medline and Embase was conducted for studies reporting the prevalence of left ventricular diastolic dysfunction or heart failure with preserved ejection fraction among type 2 diabetes patients...
July 1, 2018: Diabetes & Vascular Disease Research
Mehdi Naderi, Soodeh Shahsavari
No abstract text is available yet for this article.
July 1, 2018: Diabetes & Vascular Disease Research
Irina Filchenko, Anna Simanenkova, Svetlana Chefu, Maria Kolapkova, Timur Vlasov
OBJECTIVE: Stroke is a severe complication of type 2 diabetes mellitus. Glucagon-like peptide-1 receptor agonists have been shown to have a neuroprotective effect in experimental diabetes. The aim of this study was to determine if their neuroprotective effect is an independent property of the drug independent of glycaemic control. METHODS: This two-phase study used male Wistar rats. In the first phase, experimental animals were pretreated with liraglutide, while controls received only vehicle...
July 1, 2018: Diabetes & Vascular Disease Research
Giuliano Generoso, Isabela M Bensenor, Itamar S Santos, Raul D Santos, Alessandra C Goulart, Steven R Jones, Krishnaji R Kulkarni, Michael J Blaha, Peter P Toth, Paulo A Lotufo, Marcio Sommer Bittencourt
INTRODUCTION: High-density lipoprotein cholesterol comprises a group of heterogeneous subfractions that might have differential effects on atherosclerosis. Moreover, prior investigations suggest that the presence of diabetes (T2D) modifies the impact of some subfractions on atherosclerosis. In this study, we aimed to evaluate the association between high-density lipoprotein cholesterol subfractions and carotid intima-media thickness in the baseline assessment of the Brazilian Longitudinal Study of Adult Health participants from the São Paulo investigation centre...
July 1, 2018: Diabetes & Vascular Disease Research
Xiao Zhang, Neelam Kumari, Serena Low, Keven Ang, Darren Yeo, Lee Ying Yeoh, Allen Liu, Pek Yee Kwan, Wern Ee Tang, Subramaniam Tavintharan, Chee Fang Sum, Su Chi Lim
BACKGROUND: Fluctuation of kidney function may signify intra-glomerular microvascular hemodynamic instability. We aim to examine the association of long-term serum creatinine and estimated glomerular filtration rate variability with diabetic retinopathy. METHODS: We included type 2 diabetes mellitus patients who attended the Diabetes Centre in 2011-2014 and were followed up (median = 3.2 years). Digital colour fundus photographs were assessed for diabetic retinopathy at follow-up...
July 1, 2018: Diabetes & Vascular Disease Research
Keiji Yoshioka
The study aims to evaluate the relationship between skin autofluorescence, a marker of advanced glycated end-products accumulation in tissue, and high-sensitive cardiac troponin T, a cardiovascular biomarker, in Japanese subjects with diabetes. A total of 145 subjects with diabetes and 32 nondiabetic subjects as control attending the outpatient clinic were examined. Skin autofluorescence was measured using the AGE Reader™. Univariate and multivariate regression analyses were used to identify the factors associated with the high-sensitive cardiac troponin T and N-terminal pro-B-type natriuretic peptide values...
July 1, 2018: Diabetes & Vascular Disease Research
Viveca Ritsinger, Kerstin Brismar, Linda Mellbin, Per Näsman, Lars Rydén, Stefan Söderberg, Anna Norhammar
OBJECTIVE: To investigate the long-term prognostic value of insulin-like growth factor-binding protein 1 in patients with acute myocardial infarction. METHODS: Patients ( n = 180) with admission glucose < 11 mmol/L without previously known diabetes admitted for an acute myocardial infarction in 1998-2000 were followed for mortality and cardiovascular events (first of cardiovascular mortality/acute myocardial infarction/stroke/severe heart failure) until the end of 2011 (median 11...
September 2018: Diabetes & Vascular Disease Research
Yan Xie, Benjamin Bowe, Tingting Li, Hong Xian, Ziyad Al-Aly
Laboratory evidence suggests that urea suppresses insulin secretion and sensitivity. Emerging epidemiologic evidence suggests that higher levels of urea are associated with increased risk of incident diabetes mellitus. However, whether elevated levels of blood urea nitrogen are associated with increased risk of insulin use among people with diabetes is unknown. We used the Department of Veterans Affairs databases to assemble a cohort of 197,994 incident users of non-insulin hypoglycaemic agents with an estimated glomerular filtration rate > 60 mL/min per 1...
September 2018: Diabetes & Vascular Disease Research
Sissel Åkra, Tonje A Aksnes, Arnljot Flaa, Heidi B Eggesbø, Trine Baur Opstad, Ida U Njerve, Ingebjørg Seljeflot
BACKGROUND: Previous studies have indicated an association between interleukin-18 and glucose. Interleukin-18 becomes active when cleaved by caspase-1, activated by the NLR family pyrin domain containing-3 inflammasome. AIM: To investigate associations between glucometabolic variables and serum levels of interleukin-18 and genetic expression of interleukin-18, caspase-1 and NLR family pyrin domain containing-3 in adipose tissue and circulating leukocytes, and whether these mediators are related to the amount of abdominal adipose tissue ...
September 2018: Diabetes & Vascular Disease Research
Natalia de Albuquerque Rocha, Ian J Neeland, Peter A McCullough, Robert D Toto, Darren K McGuire
Sodium-glucose cotransporter 2 inhibitors are antihyperglycaemic medications with an emerging evidence base for cardiovascular and kidney disease risk reduction. Sodium-glucose cotransporter 2 inhibitors medications lower plasma glucose by inhibiting glucose reabsorption in the proximal tubule of the kidney independent of insulin. Furthermore, they reduce intraglomerular pressure by restoring tubuloglomerular feedback. Large cardiovascular outcome trials of both empagliflozin and canagliflozin have consistently shown beneficial kidney effects that go beyond glycaemic control, such as reducing risk for incident nephropathy and progression of chronic kidney disease...
September 2018: Diabetes & Vascular Disease Research
Michael A Nauck, Karen Tornøe, Søren Rasmussen, Marianne Bach Treppendahl, Steven P Marso
OBJECTIVE: Animal studies demonstrated that glucagon-like peptide-1 receptor agonists reduce myocardial necrosis following regional ischaemia induction. This effect may improve cardiovascular outcomes after myocardial infarction. Risk of cardiovascular death or hospitalisation for heart failure after myocardial infarction was evaluated in patients with type 2 diabetes at high cardiovascular risk in the LEADER trial. METHODS: Data from patients randomised to liraglutide or placebo, in addition to standard of care, in Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) (NCT01179048) were analysed post hoc...
September 2018: Diabetes & Vascular Disease Research
Hiroyuki Takashima, Yoshinori Yoshida, Chinami Nagura, Tetsuya Furukawa, Ritsukou Tei, Takashi Maruyama, Noriaki Maruyama, Masanori Abe
BACKGROUND: To evaluate the renoprotective effects of canagliflozin, we assessed the albuminuria-lowering effect in Japanese type 2 diabetes patients with chronic kidney disease (CKD). METHODS: In this prospective, open-label, parallel-group study, type 2 diabetes patients with CKD were randomized to receive either oral canagliflozin (100 mg/day) or usual care (control group) for 52 weeks. Endpoints included changes in urinary albumin-to-creatinine ratio (UACR), other urinary biomarkers, laboratory parameters, and adverse events...
September 2018: Diabetes & Vascular Disease Research
Peta Ellen Tehan, Mathew Sebastian, Alex Louise Barwick, Vivienne Helaine Chuter
BACKGROUND: Continuous-wave Doppler is frequently used for detecting peripheral arterial disease in patients with diabetes; however, there is limited evidence investigating diagnostic accuracy. This study aimed to determine sensitivity and specificity of continuous-wave Doppler for detecting peripheral arterial disease in populations with, and without, diabetes and to investigate the influence of disease severity on sensitivity of continuous-wave Doppler for detecting peripheral arterial disease...
September 2018: Diabetes & Vascular Disease Research
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