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Diabetes & Vascular Disease Research

Hamlin Emory, Neptune Mizrahi
We present clinical, electroencephalographic and low-resolution electromagnetic tomography data that support combined treatment with insulin and a monoamine oxidase inhibitor in a patient with type 1 diabetes. We suggest that brain imaging data can identify a subgroup of patients who are likely to benefit from an insulin regimen and monoamine oxidase inhibition to improve glycaemic control, cardiovascular function, normalize the circadian rhythm and restore perception of glycaemic awareness.
November 24, 2016: Diabetes & Vascular Disease Research
R A Ajjan
No abstract text is available yet for this article.
November 2016: Diabetes & Vascular Disease Research
Peter J Grant
No abstract text is available yet for this article.
November 2016: Diabetes & Vascular Disease Research
Christian Ellul, Alfred Gatt
BACKGROUND: First-line therapy for claudicants with diabetes include supervised exercise programmes to improve walking distance. However, exercise comes with a number of barriers and may be contraindicated in certain conditions. The aim of this study was to evaluate whether calf-muscle electro-stimulation improves claudication distance. METHOD: A prospective, one-group, pretest-posttest study design was employed on 40 participants living with type 2 diabetes mellitus, peripheral artery disease (ankle-brachial pressure index < 0...
November 2016: Diabetes & Vascular Disease Research
Debora Sitnik, Itamar S Santos, Alessandra C Goulart, Henrique L Staniak, JoAnn E Manson, Paulo A Lotufo, Isabela M Bensenor
We aimed to study the association between fasting plasma glucose, diabetes incidence and cardiovascular burden after 10-12 years. We evaluated diabetes and cardiovascular events incidences, carotid intima-media thickness and coronary artery calcium scores in ELSA-Brasil (the Brazilian Longitudinal Study of Adult Health) baseline (2008-2010) of 1536 adults without diabetes in 1998. We used regression models to estimate association with carotid intima-media thickness (in mm), coronary artery calcium scores (in Agatston points) and cardiovascular events according to fasting plasma glucose in 1998...
November 2016: Diabetes & Vascular Disease Research
Sarah Mahmoud Gamal, Nermeen Bakr Sadek, Laila Ahmed Rashed, Heba Mohamed Shawky, Maha Mohamed Gamal El-Din
AIMS: To investigate the possible protective effect of elevated undercarboxylated osteocalcin on diabetic cardiomyopathy mechanisms and risk factors. METHODS: In all, 32 male rats were divided into four groups: control, diabetic, diabetic warfarin and normal warfarin-treated groups. Isolated heart functions were assessed; fasting serum insulin, glucose and glycosylated haemoglobin, homeostasis model assessment insulin resistance and lipid profile were investigated...
November 2016: Diabetes & Vascular Disease Research
Yuji Ishibashi, Takanori Matsui, Sho-Ichi Yamagishi
OBJECTIVE: Inhibitors of sodium-glucose cotransporter 2 ameliorate hyperglycaemia in diabetes by increasing urinary glucose excretion. However, the effects of sodium-glucose cotransporter 2 inhibitors on tubulointerstitial damage in diabetic nephropathy are not fully elucidated. We examined whether tofogliflozin, an inhibitor of sodium-glucose cotransporter 2, suppressed renal damage in KKAy/Ta mice, obese and type 2 diabetic animals. MATERIALS AND METHODS: Male 8-week-old KKAy/Ta mice or control C57BL/6J mice were kept on a standard diet with or without 0...
November 2016: Diabetes & Vascular Disease Research
Wentao Li, Muwei Li, Chuanyu Gao, Xianpei Wang, Datun Qi, Jun Liu, Qiangsong Jin
To evaluate the influence of type 2 diabetes mellitus on the long-term outcomes of Chinese patients with previous myocardial infarction, we studied 864 patients with previous myocardial infarction, including 251 with type 2 diabetes mellitus and 613 without type 2 diabetes mellitus, over a median follow-up time of 2.9 years. The type 2 diabetes mellitus patients were subdivided into 95 insulin-treated diabetes mellitus and 156 non-insulin-treated diabetes mellitus subjects. The crude incidences (per 1000 patient-years) in the type 2 diabetes mellitus subjects versus the non-type 2 diabetes mellitus subjects were 43...
November 2016: Diabetes & Vascular Disease Research
Cinzia D'Amato, Roberto Morganti, Carla Greco, Federica Di Gennaro, Laura Cacciotti, Susanna Longo, Giorgia Mataluni, Davide Lauro, Girolama A Marfia, Vincenza Spallone
AIMS: To investigate the independent effect on depression of painless diabetic polyneuropathy, painful diabetic polyneuropathy, and general and diabetes-related comorbidities. METHODS: In 181 patients, the presence of painless diabetic polyneuropathy, painful diabetic polyneuropathy, comorbidities and depression was assessed using the Michigan Neuropathy Screening Instrument Questionnaire, the Michigan Diabetic Neuropathy Score, nerve conduction studies, the Douleur Neuropathique en 4 Questions, the Charlson Comorbidity Index and the Beck Depression Inventory-II...
November 2016: Diabetes & Vascular Disease Research
Peter J Grant
No abstract text is available yet for this article.
September 2016: Diabetes & Vascular Disease Research
Andrew Mn Walker, Peysh A Patel, Adil Rajwani, David Groves, Christine Denby, Lorraine Kearney, Robert J Sapsford, Klaus K Witte, Mark T Kearney, Richard M Cubbon
BACKGROUND: Diabetes mellitus is associated with an increased risk of death and hospitalisation in patients with chronic heart failure. Better understanding of potential underlying mechanisms may aid the development of diabetes mellitus-specific chronic heart failure therapeutic strategies. METHODS: Prospective observational cohort study of 628 patients with chronic heart failure associated with left ventricular systolic dysfunction receiving contemporary evidence-based therapy...
September 2016: Diabetes & Vascular Disease Research
Hisato Takagi, Takuya Umemoto
PURPOSE: To summarize the association of diabetes with abdominal aortic aneurysm rupture, we reviewed currently available studies with a systematic literature search and meta-analytic evaluation. METHODS: To identify all studies reporting the association of diabetes with abdominal aortic aneurysm rupture, MEDLINE and EMBASE were searched through July 2015. For each study, data regarding diabetes prevalence in both the ruptured and non-ruptured groups were used to generate an unadjusted odds ratio for abdominal aortic aneurysm rupture and 95% confidence intervals...
September 2016: Diabetes & Vascular Disease Research
Naseer Ahmad, G Neil Thomas, Paramjit Gill, Francesco Torella
AIMS: To determine the prevalence of amputation and revascularisation among diabetics and non-diabetics between 2003 and 2013. METHODS: Retrospective analysis of English hospital data with census estimates for population aged 50-84 years. RESULTS: There were 42,294 major and 52,525 minor amputations and 355,545 revascularisations. Major amputation rates fell by 20% (27.7-22.9), with minor amputations (22.9-35.2) and revascularisations (199...
September 2016: Diabetes & Vascular Disease Research
Henrik Wagner, Helene Fischer, Marie Degerblad, Michael Alvarsson, Thomas Gustafsson
PURPOSE: Insulin sensitivity changes in response to exercise training demonstrate a large variation. Vascular endothelial growth factor A could promote increased insulin sensitivity through angiogenesis. We investigated associations between changes in expression of key genes and insulin sensitivity, aerobic capacity and glycaemic control following exercise training in diabetes mellitus type 2. METHODS: Subjects with diabetes mellitus type 2 underwent 12 weeks of structured exercise...
September 2016: Diabetes & Vascular Disease Research
Peter Godsk Jørgensen, Magnus T Jensen, Rasmus Mogelvang, Bernt Johan von Scholten, Jan Bech, Thomas Fritz-Hansen, Søren Galatius, Tor Biering-Sørensen, Henrik U Andersen, Tina Vilsbøll, Peter Rossing, Jan S Jensen
OBJECTIVES: We aimed to determine the prevalence of echocardiographic abnormalities and their relation to clinical characteristics and cardiac symptoms in a large, contemporary cohort of patients with type 2 diabetes. RESULTS: A total of 1030 patients with type 2 diabetes participated. Echocardiographic abnormalities were present in 513 (49.8%) patients, mainly driven by a high prevalence of diastolic dysfunction 178 (19.4%), left ventricular hypertrophy 213 (21...
September 2016: Diabetes & Vascular Disease Research
Oskar Kövamees, Alexey Shemyakin, John Pernow
BACKGROUND: Endothelial dysfunction contributes to the development of vascular complication in diabetes. Arginase has emerged as a key mechanism behind endothelial dysfunction by its reciprocal regulation of nitric oxide production by substrate competition. We hypothesized that increased arginase activity in patients with type 2 diabetes shifts the metabolism of l-arginine from nitric oxide synthase to arginase resulting in an increase in the plasma ratio of ornithine/citrulline, and that this ratio is associated with endothelial dysfunction...
September 2016: Diabetes & Vascular Disease Research
Rinkoo Dalan, Huiling Liew, Liuh Ling Goh, Xiao Gao, Daniel Ek Chew, Bernhard O Boehm, Melvin Khee Shing Leow
The haptoglobin 2-2 genotype is associated with atherosclerosis in type 2 diabetes mellitus. We examined the associations of the haptoglobin 2-2 genotype with C-reactive protein (high-sensitivity C-reactive protein) and carotid artery intima-media thickness, adjusting for age, gender, ethnicity, type 2 diabetes mellitus, smoking status, body mass index, blood pressure, glycated haemoglobin, non-high-density lipoprotein cholesterol and medications via logistic multivariate regression in 200 subjects (160 type 2 diabetes mellitus versus 40 healthy individuals)...
September 2016: Diabetes & Vascular Disease Research
Dinesh Selvarajah, Timothy Hughes, Josie Reeves, Elaine Boland, Jefferson Marques, Rajiv Gandhi, Paul D Griffiths, Solomon Tesfaye, Iain D Wilkinson
OBJECTIVE: The aims of this study were (1) to examine cerebrovascular autoregulation in subjects with impaired glucose tolerance and type 2 diabetes and (2) to clarify whether cardiovascular autonomic nerve function is associated with abnormal cerebrovascular autoregulation. RESEARCH DESIGN AND METHODS: Totally, 46 subjects were recruited (12 = impaired glucose tolerance, 17 = type 2 diabetes and 17 = healthy volunteers). Arterial blood flow was assessed within the internal carotid artery at baseline and 20 min after intravenous pharmacological stress (1 g acetazolamide), using quantitative magnetic resonance phase-contrast angiography...
September 2016: Diabetes & Vascular Disease Research
Ljubica Georgievska-Ismail, Planinka Zafirovska, Zarko Hristovski
OBJECTIVE: To evaluate additional role of left atrial two-dimensional speckle tracking echocardiography in patients with diabetes mellitus type 2, 218 patients with heart failure with preserved left ventricular ejection fraction divided according to the presence of diabetes mellitus (108 with and 110 without) were enrolled in the study. METHODS: Traditional parameters using two-dimensional echocardiography and Doppler imaging were measured as expressions of left ventricular diastolic function as well as peak atrial longitudinal strain and peak atrial contraction strain were measured using two-dimensional speckle tracking echocardiography...
July 12, 2016: Diabetes & Vascular Disease Research
Lisa Arnetz, Camilla Hage, Kerstin Brismar, Sergiu-Bogdan Catrina, Anna Norhammar, Pia Lundman, Märit Wallander, Lars Ryden, Linda Mellbin
PURPOSE: To investigate whether sitagliptin affects copeptin and osmolality, suggesting arginine vasopressin activation and a potential for fluid retention, compared with placebo, in patients with a recent acute coronary syndrome and newly discovered type 2 diabetes or impaired glucose tolerance. A second aim was to confirm whether copeptin correlated with insulin-like growth factor binding protein-1. METHODS: Fasting blood samples were used from the BEta-cell function in Glucose abnormalities and Acute Myocardial Infarction trial, in which patients recently hospitalized due to acute coronary syndrome and with newly detected abnormal glucose tolerance were randomized to sitagliptin 100 mg once daily (n = 34) or placebo (n = 37)...
July 2016: Diabetes & Vascular Disease Research
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