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Diabetes & Vascular Disease Research

Yahor Tratsiakovich, Attila Kiss, Adrian T Gonon, Jiangning Yang, Per-Ove Sjöquist, John Pernow
AIM: RhoA/Rho-associated kinase and arginase are implicated in vascular complications in diabetes. This study investigated whether RhoA/Rho-associated kinase and arginase inhibition protect from myocardial ischaemia-reperfusion injury in type 1 diabetes and the mechanisms behind these effects. METHODS: Rats with streptozotocin-induced type 1 diabetes and non-diabetic rats were subjected to 30 min myocardial ischaemia and 2 h reperfusion after being randomized to treatment with (1) saline, (2) RhoA/Rho-associated kinase inhibitor hydroxyfasudil, (3) nitric oxide synthase inhibitor N(G)-monomethyl-l-arginine monoacetate followed by hydroxyfasudil, (4) arginase inhibitor N-omega-hydroxy-nor-l-arginine, (5) N(G)-monomethyl-l-arginine monoacetate followed by N-omega-hydroxy-nor-l-arginine or (6) N(G)-monomethyl-l-arginine monoacetate given intravenous before ischaemia...
February 1, 2017: Diabetes & Vascular Disease Research
Liubao Gu, Liji Huang, Haidi Wu, Qinglin Lou, Rongwen Bian
BACKGROUND: Serum uric acid has shown to be a predictor of renal disease progression in most but not all studies. This study aims to test whether renal function-normalized serum uric acid is superior to serum uric acid as the predictor of incident chronic kidney disease in type 2 diabetes mellitus patients. METHODS: In this study, 1339 type 2 diabetes mellitus patients with estimated glomerular filtration rate ⩾60 mL/min/1.73 m(2) and normouricemia were included...
February 1, 2017: Diabetes & Vascular Disease Research
Thushan S Hettige, Mark E Cooper
No abstract text is available yet for this article.
January 1, 2017: Diabetes & Vascular Disease Research
Nikolaus Marx
No abstract text is available yet for this article.
January 1, 2017: Diabetes & Vascular Disease Research
Carrie Ferguson, Karen M Birch, Jack O Garnham, Klaus K Witte
No abstract text is available yet for this article.
January 1, 2017: Diabetes & Vascular Disease Research
Maria Isabel Smaradottir, Viveca Ritsinger, Viveca Gyberg, Anna Norhammar, Per Näsman, Linda G Mellbin
OBJECTIVE: To characterize copeptin levels and to explore its prognostic importance in patients with acute myocardial infarction with newly detected glucose abnormalities. METHODS: Copeptin was measured in 166 patients with acute myocardial infarction without known diabetes and in 168 age- and gender-matched controls. Participants were classified as having normal glucose tolerance or abnormal glucose tolerance (impaired glucose tolerance + type 2 diabetes mellitus) by oral glucose tolerance test...
January 1, 2017: Diabetes & Vascular Disease Research
Rune Byrkjeland, Ida U Njerve, Harald Arnesen, Ingebjørg Seljeflot, Svein Solheim
OBJECTIVE: We have previously reported insignificant changes in HbA1c after exercise in patients with both type 2 diabetes and coronary artery disease. In this study, we investigated the effect of exercise on endothelial function and possible associations between changes in endothelial function and HbA1c. METHODS: Patients with type 2 diabetes and coronary artery disease ( n = 137) were randomised to 12 months exercise or standard follow-up. Endothelial function was assessed by circulating biomarkers (E-selectin, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, von Willebrand factor, tissue plasminogen activator antigen, asymmetric dimethylarginine and L-arginine/asymmetric dimethylarginine ratio)...
January 1, 2017: Diabetes & Vascular Disease Research
Silvia Charwat-Resl, Rajashri Yarragudi, Moritz Heimbach, Karoline Leitner, Michael Leutner, Jutta Gamper, Georgiana-Aura Giurgea, Markus Mueller, Renate Koppensteiner, Michael E Gschwandtner, Alexandra Kautzky-Willer, Oliver Schlager
OBJECTIVE: In the long term, diabetes mellitus is potentially associated with the occurrence of microvascular damage. This study sought to assess whether a history of prior gestational diabetes mellitus is associated with long-term effects on the women's microcirculation. METHODS: Within the scope of a long-term follow-up of the 'Viennese Post-Gestational Diabetes Project', women with prior gestational diabetes mellitus as well as women with previous pregnancy but with no history of gestational diabetes mellitus (controls) were enrolled in this cross-sectional study...
January 1, 2017: Diabetes & Vascular Disease Research
Vibeke Bratseth, Rune Byrkjeland, Ida U Njerve, Svein Solheim, Harald Arnesen, Ingebjørg Seljeflot
We investigated the effects of 12-month exercise training on hypercoagulability in patients with combined type 2 diabetes mellitus and coronary artery disease. Associations with severity of disease were further explored. Patients ( n = 131) were randomized to exercise training or a control group. Blood was collected at inclusion and after 12 months. Tissue factor, free and total tissue factor pathway inhibitor, prothrombin fragment 1 + 2 (F1 + 2) and D-dimer were determined by enzyme-linked immunosorbent assay and ex vivo thrombin generation by the calibrated automated thrombogram assay...
January 1, 2017: Diabetes & Vascular Disease Research
Anna Duda-Sobczak, Aleksandra Araszkiewicz, Magdalena Urbas, Lukasz Borucki, Katarzyna Kulas, Maciej Chudzinski, Aleksandra Suwalska, Dorota Zozulinska-Ziolkiewicz
INTRODUCTION: Olfactory dysfunction is suggested to be a clinical manifestation of central diabetic neuropathy. The aim of the study was to assess olfactory function in adult patients with type 1 diabetes. MATERIALS AND METHODS: A total of 106 patients with type 1 diabetes and 30 healthy subjects were included in the study. We evaluated the metabolic control of diabetes and the presence of chronic complications. Olfactory function was assessed with Sniffin' Sticks...
January 1, 2017: Diabetes & Vascular Disease Research
Anka P Brozic, Susan Marzolini, Jack M Goodman
PURPOSE: To determine the effects of a 12-week cardiac rehabilitation programme of aerobic and resistance exercise training on arterial stiffness, peak calf vasodilatory reserve, and haemostatic markers in patients with type 2 diabetes. METHODS: Observational cohort study examining effects of 12 weeks of exercise training in 23 subjects (13 men, 10 women; mean age of 56.1 ± 10.1 years) with type 2 diabetes mellitus. Subjects performed exercise training for 12 weeks [aerobic training 5 days/week, 70%-75% peak cardiovascular fitness (VO2peak) and resistance training 2-3 days/week, 60% of one repetition maximum]...
January 1, 2017: Diabetes & Vascular Disease Research
Kirsten Riches, John Huntriss, Claire Keeble, Ian C Wood, David J O'Regan, Neil A Turner, Karen E Porter
Type 2 diabetes mellitus prevalence is growing globally, and the leading cause of mortality in these patients is cardiovascular disease. Epigenetic mechanisms such as microRNAs (miRs) and DNA methylation may contribute to complications of type 2 diabetes mellitus. We discovered an aberrant type 2 diabetes mellitus-smooth muscle cell phenotype driven by persistent up-regulation of miR-145. This study aimed to determine whether elevated expression was due to changes in methylation at the miR-145 promoter. Smooth muscle cells were cultured from saphenous veins of 22 non-diabetic and 22 type 2 diabetes mellitus donors...
March 2017: Diabetes & Vascular Disease Research
Minjoo Kim, Minkyung Kim, Ji Yun Han, Sang-Hyun Lee, Sun Ha Jee, Jong Ho Lee
To determine differences between peripheral blood mononuclear cells and the plasma metabolites in patients with impaired fasting glucose or type 2 diabetes and healthy controls. In all, 65 nononobese patients (aged 30-70 years) with impaired fasting glucose or type 2 diabetes and 65 nonobese sex-matched healthy controls were included, and fasting peripheral blood mononuclear cell and plasma metabolomes were profiled. The diabetic or impaired fasting glucose patients showed higher circulating and peripheral blood mononuclear cell lipoprotein phospholipase A2 activities, high-sensitivity C-reactive protein and tumour necrosis factor-α than controls...
March 2017: Diabetes & Vascular Disease Research
Junxia Zhang, Lin Xiang, Bilin Zhang, Yangyang Cheng
OBJECTIVE: To reveal the effect of hyperuricaemia on endothelial function in normoglycaemic first-degree relatives of type 2 diabetes mellitus. METHODS: In all, 40 first-degree relatives of type 2 diabetes mellitus with hyperuricaemia, 40 first-degree relatives of type 2 diabetes mellitus with normouricaemia and 35 healthy subjects without diabetic family history were recruited in this study. Anthropometric parameters as well as blood pressure, blood lipids, fasting blood glucose, fasting insulin, C-reactive protein, tumour necrosis factor-α and interleukin-6 were measured...
March 2017: Diabetes & Vascular Disease Research
Wen-Jia Chen, Yue Liu, Yu-Bin Sui, Bo Zhang, Xiao-Hui Zhang, Xin-Hua Yin
BACKGROUND: Musclin is a newly identified skeletal muscle-derived secretory factor, which has been recently characterized as a stimulator that induces insulin resistance in mice. However, the pathophysiological role of musclin in humans remains poorly understood. The aim of this study was to explore the potential correlations between musclin plasma levels and various metabolic parameters in patients with type 2 diabetes mellitus. MATERIALS AND METHODS: In this hospital-based study, plasma samples were collected from the enrolled individuals, including 38 newly diagnosed, treatment-naive type 2 diabetes mellitus patients and 41 age- and gender-matched control subjects...
March 2017: Diabetes & Vascular Disease Research
Viveca Ritsinger, Kerstin Brismar, Klas Malmberg, Linda Mellbin, Per Näsman, Lars Rydén, Stefan Söderberg, Åke Tenerz, Anna Norhammar
OBJECTIVE: Adiponectin and leptin are associated with insulin resistance and cardiovascular disease. Information on the prognostic value after an acute myocardial infarction is still conflicting. METHODS: Patients (n = 180) without known diabetes and with admission glucose of <11 mmol/L admitted for an acute myocardial infarction in 1998-2000 were followed for mortality and cardiovascular events (first of cardiovascular mortality/acute myocardial infarction/stroke/heart failure) until the end of 2011 (median: 11...
March 2017: Diabetes & Vascular Disease Research
Yan Chen, Hongmei Chen, Yochai Birnbaum, Manjyot K Nanhwan, Mandeep Bajaj, Yumei Ye, Jinqiao Qian
PURPOSE: To assess the effects of Aleglitazar on hyperglycaemia-induced apoptosis. METHODS: We incubated human cardiomyocytes, cardiomyocytes from cardiac-specific peroxisome proliferator-activated receptor-γ knockout or wild-type mice in normoglycaemic or hyperglycaemic conditions (glucose 25 mM). Cells were treated with different concentrations of Aleglitazar for 48 h. We measured viability, apoptosis, caspase-3 activity, cytochrome-C release, total antioxidant capacity and reactive oxygen species formation in the treated cardiomyocytes...
March 2017: Diabetes & Vascular Disease Research
Sony S Thazhath, Chinmay S Marathe, Tongzhi Wu, Jessica Chang, Joan Khoo, Paul Kuo, Helen L Checklin, Michelle J Bound, Rachael S Rigda, Michael Horowitz, Karen L Jones, Christopher K Rayner
AIM: To evaluate the effects of the glucagon-like peptide-1 receptor agonist, exenatide, on blood pressure and heart rate during an intraduodenal glucose infusion in type 2 diabetes. METHODS: Nine subjects with type 2 diabetes were randomised to receive intravenous exenatide or saline control in a crossover design. Glucose (3 kcal min(-1)) was infused via an intraduodenal manometry catheter for 60 min. Blood pressure, heart rate, and the frequency and amplitude of duodenal pressure waves were measured at regular intervals...
January 2017: Diabetes & Vascular Disease Research
Bettina Hartmann, Christian Fottner, Karin Herrmann, Tobias Limbourg, Matthias M Weber, Karlheinz Beckh
AIMS: A major proportion of patients with diabetic foot syndrome are older than 65 years. Little is known about outcomes of these elderly patients. METHODS: We analysed 245 treatment cases in an observational single-centre study for comorbidities and outcomes over a 6-month period. RESULTS: In all, 122 patients had peripheral arterial disease which was significantly increasing with age (n = 245, df = 1, χ(2) = 23.06, p ⩽ 0...
January 2017: Diabetes & Vascular Disease Research
Benjamin J Gray, Jeffrey W Stephens, Daniel Turner, Michael Thomas, Sally P Williams, Kerry Morgan, Meurig Williams, Sam Rice, Richard M Bracken
This study examined the relationship between cardiorespiratory fitness determined by a non-exercise testing method for estimating fitness and predicted risk of developing type 2 diabetes mellitus using five risk assessments/questionnaires (Leicester Diabetes Risk Score, QDiabetes, Cambridge Risk Score, Finnish Diabetes Risk Score and American Diabetes Association Diabetes Risk Test). Retrospective analysis was performed on 330 female individuals with no prior diagnosis of cardiovascular disease or type 2 diabetes mellitus who participated in the Prosiect Sir Gâr workplace initiative in Carmarthenshire, South Wales...
January 2017: Diabetes & Vascular Disease Research
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