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Diabetes & Vascular Disease Research

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https://www.readbyqxmd.com/read/30014713/the-association-of-serum-creatinine-and-estimated-glomerular-filtration-rate-variability-with-diabetic-retinopathy-in-asians-with-type-2-diabetes-a-nested-case-control-study
#1
Xiao Zhang, Neelam Kumari, Serena Low, Keven Ang, Darren Yeo, Lee Ying Yeoh, Allen Liu, Pek Yee Kwan, Wern Ee Tang, Subramaniam Tavintharan, Chee Fang Sum, Su Chi Lim
BACKGROUND: Fluctuation of kidney function may signify intra-glomerular microvascular hemodynamic instability. We aim to examine the association of long-term serum creatinine and estimated glomerular filtration rate variability with diabetic retinopathy. METHODS: We included type 2 diabetes mellitus patients who attended the Diabetes Centre in 2011-2014 and were followed up (median = 3.2 years). Digital colour fundus photographs were assessed for diabetic retinopathy at follow-up...
July 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29974791/blood-urea-nitrogen-and-risk-of-insulin-use-among-people-with-diabetes
#2
Yan Xie, Benjamin Bowe, Tingting Li, Hong Xian, Ziyad Al-Aly
Laboratory evidence suggests that urea suppresses insulin secretion and sensitivity. Emerging epidemiologic evidence suggests that higher levels of urea are associated with increased risk of incident diabetes mellitus. However, whether elevated levels of blood urea nitrogen are associated with increased risk of insulin use among people with diabetes is unknown. We used the Department of Veterans Affairs databases to assemble a cohort of 197,994 incident users of non-insulin hypoglycaemic agents with an estimated glomerular filtration rate > 60 mL/min per 1...
July 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29972075/skin-autofluorescence-is-associated-with-high-sensitive-cardiac-troponin-t-a-circulating-cardiac-biomarker-in-japanese-patients-with-diabetes-a-cross-sectional-study
#3
Keiji Yoshioka
The study aims to evaluate the relationship between skin autofluorescence, a marker of advanced glycated end-products accumulation in tissue, and high-sensitive cardiac troponin T, a cardiovascular biomarker, in Japanese subjects with diabetes. A total of 145 subjects with diabetes and 32 nondiabetic subjects as control attending the outpatient clinic were examined. Skin autofluorescence was measured using the AGE Reader™. Univariate and multivariate regression analyses were used to identify the factors associated with the high-sensitive cardiac troponin T and N-terminal pro-B-type natriuretic peptide values...
July 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29972041/interleukin-18-and-the-nlr-family-pyrin-domain-containing-3-inflammasome-in-adipose-tissue-are-strongly-associated-with-glucometabolic-variables-in-a-cohort-of-middle-aged-men
#4
Sissel Åkra, Tonje A Aksnes, Arnljot Flaa, Heidi B Eggesbø, Trine Baur Opstad, Ida U Njerve, Ingebjørg Seljeflot
BACKGROUND: Previous studies have indicated an association between interleukin-18 and glucose. Interleukin-18 becomes active when cleaved by caspase-1, activated by the NLR family pyrin domain containing-3 inflammasome. AIM: To investigate associations between glucometabolic variables and serum levels of interleukin-18 and genetic expression of interleukin-18, caspase-1 and NLR family pyrin domain containing-3 in adipose tissue and circulating leukocytes, and whether these mediators are related to the amount of abdominal adipose tissue ...
July 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29992830/elevated-levels-of-insulin-like-growth-factor-binding-protein-1-predict-outcome-after-acute-myocardial-infarction-a-long-term-follow-up-of-the-glucose-tolerance-in-patients-with-acute-myocardial-infarction-gami-cohort
#5
Viveca Ritsinger, Kerstin Brismar, Linda Mellbin, Per Näsman, Lars Rydén, Stefan Söderberg, Anna Norhammar
OBJECTIVE: To investigate the long-term prognostic value of insulin-like growth factor-binding protein 1 in patients with acute myocardial infarction. METHODS: Patients ( n = 180) with admission glucose < 11 mmol/L without previously known diabetes admitted for an acute myocardial infarction in 1998-2000 were followed for mortality and cardiovascular events (first of cardiovascular mortality/acute myocardial infarction/stroke/severe heart failure) until the end of 2011 (median 11...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29963920/effects-of-sodium-glucose-co-transporter-2-inhibitors-on-the-kidney
#6
Natalia de Albuquerque Rocha, Ian J Neeland, Peter A McCullough, Robert D Toto, Darren K McGuire
Sodium-glucose cotransporter 2 inhibitors are antihyperglycaemic medications with an emerging evidence base for cardiovascular and kidney disease risk reduction. Sodium-glucose cotransporter 2 inhibitors medications lower plasma glucose by inhibiting glucose reabsorption in the proximal tubule of the kidney independent of insulin. Furthermore, they reduce intraglomerular pressure by restoring tubuloglomerular feedback. Large cardiovascular outcome trials of both empagliflozin and canagliflozin have consistently shown beneficial kidney effects that go beyond glycaemic control, such as reducing risk for incident nephropathy and progression of chronic kidney disease...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29947247/cardiovascular-outcomes-in-patients-who-experienced-a-myocardial-infarction-while-treated-with-liraglutide-versus-placebo-in-the-leader-trial
#7
Michael A Nauck, Karen Tornøe, Søren Rasmussen, Marianne Bach Treppendahl, Steven P Marso
OBJECTIVE: Animal studies demonstrated that glucagon-like peptide-1 receptor agonists reduce myocardial necrosis following regional ischaemia induction. This effect may improve cardiovascular outcomes after myocardial infarction. Risk of cardiovascular death or hospitalisation for heart failure after myocardial infarction was evaluated in patients with type 2 diabetes at high cardiovascular risk in the LEADER trial. METHODS: Data from patients randomised to liraglutide or placebo, in addition to standard of care, in Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) (NCT01179048) were analysed post hoc...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29923427/renoprotective-effects-of-canagliflozin-a-sodium-glucose-cotransporter-2-inhibitor-in-type-2-diabetes-patients-with-chronic-kidney-disease-a-randomized-open-label-prospective-trial
#8
Hiroyuki Takashima, Yoshinori Yoshida, Chinami Nagura, Tetsuya Furukawa, Ritsukou Tei, Takashi Maruyama, Noriaki Maruyama, Masanori Abe
BACKGROUND: To evaluate the renoprotective effects of canagliflozin, we assessed the albuminuria-lowering effect in Japanese type 2 diabetes patients with chronic kidney disease (CKD). METHODS: In this prospective, open-label, parallel-group study, type 2 diabetes patients with CKD were randomized to receive either oral canagliflozin (100 mg/day) or usual care (control group) for 52 weeks. Endpoints included changes in urinary albumin-to-creatinine ratio (UACR), other urinary biomarkers, laboratory parameters, and adverse events...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29923421/corrigendum
#9
(no author information available yet)
Gaspari T, Spizzo I, Liu HB, et al. (2018) Dapagliflozin attenuates human vascular endothelial cell activation and induces vasorelaxation: A potential mechanism for inhibition of atherogenesis. Diabetes & Vascular Disease Research 2018; 15(1): 64-73. DOI: 10.1177/1479164117733626 The authors have highlighted a typographical error which exists in the NFκB reverse primer sequence outlined in the paper. The published NFκB reverse primer sequence reads 5'-TGT-CGT-GCT-CCA-CAC-AGC-CAG-GT-3'. The correct sequence for the NFκB reverse primer sequence should read 5'-TGT-CGT-GCT-CCA-CAG-CCA-GGT-3'...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29923420/how-sensitive-and-specific-is-continuous-wave-doppler-for-detecting-peripheral-arterial-disease-in-people-with-and-without-diabetes-a-cross-sectional-study
#10
Peta Ellen Tehan, Mathew Sebastian, Alex Louise Barwick, Vivienne Helaine Chuter
BACKGROUND: Continuous-wave Doppler is frequently used for detecting peripheral arterial disease in patients with diabetes; however, there is limited evidence investigating diagnostic accuracy. This study aimed to determine sensitivity and specificity of continuous-wave Doppler for detecting peripheral arterial disease in populations with, and without, diabetes and to investigate the influence of disease severity on sensitivity of continuous-wave Doppler for detecting peripheral arterial disease...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29911415/risk-factors-for-the-development-of-micro-vascular-complications-of-type-2-diabetes-in-a-single-centre-cohort-of-patients
#11
Marsida Teliti, Giulia Cogni, Lucia Sacchi, Arianna Dagliati, Simone Marini, Valentina Tibollo, Pasquale De Cata, Riccardo Bellazzi, Luca Chiovato
AIMS: In type 2 diabetes, we aimed at clarifying the role of glycated haemoglobin variability and other risk factors in the development of the main micro-vascular complications: peripheral neuropathy, nephropathy and retinopathy. METHODS: In a single-centre cohort of 900 patients, glycated haemoglobin variability was evaluated as intra-individual standard deviation, adjusted standard deviation and coefficient of variation of serially measured glycated haemoglobin in the 2-year period before a randomly selected index visit...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29895175/evaluation-of-the-lamina-cribrosa-in-patients-with-diabetes-mellitus-using-enhanced-depth-imaging-spectral-domain-optical-coherence-tomography
#12
Serkan Akkaya, Bekir Küçük, Hatice Karaköse Doğan, Ertuğrul Can
PURPOSE: To compare the lamina cribrosa thickness and anterior lamina cribrosa depth between patients with and without diabetes mellitus and to investigate the effect of metabolic control and duration of diabetes mellitus on lamina cribrosa thickness and anterior lamina cribrosa depth using enhanced depth imaging spectral-domain optical coherence tomography. METHODS: A total of 70 patients were enrolled in this cross-sectional study and were divided into the diabetes and control groups...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29893142/microangiopathy-is-associated-with-bone-loss-in-female-type-2-diabetes-mellitus-patients
#13
Ni Zhong, Youyang Zhang, Xiangling Pu, Bei Xu, Mingxin Xu, Haidong Cai, Ge Zhang, Ran Cui, Hui Sheng, Shen Qu
OBJECTIVE: Type 2 diabetes mellitus complicated with microvascular diseases can be used as a model to study the relationship between bone health and the microvascular situation. METHODS: A total of 2,170 patients with type 2 diabetes mellitus (1,188 postmenopausal females and 982 males aged ⩾50 years) were included in our cross-sectional study. These patients were grouped according to 24-hour urine protein level: Group I (<30 mg), Group II (30-299 mg) and Group III (≥300 mg)...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29874945/diabetes-mellitus-and-abdominal-aortic-aneurysms-a-review-of-the-mechanisms-underlying-the-negative-relationship
#14
Nikesh Dattani, Robert D Sayers, Matthew J Bown
INTRODUCTION: Diabetes mellitus appears to be negatively associated with abdominal aortic aneurysm; however, the mechanisms underlying this relationship remain poorly understood. The aim of this article is to provide a comprehensive review of the currently understood biological pathways underlying this relationship. METHODS: A review of the literature ('diabetes' OR 'hyperglycaemia' AND 'aneurysm') was performed and relevant studies grouped into biological pathways...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29871496/biomarkers-of-vascular-injury-and-endothelial-dysfunction-after-recent-glucose-intolerance-in-pregnancy
#15
Harpreet S Bajaj, Chang Ye, Anthony J Hanley, Mathew Sermer, Bernard Zinman, Ravi Retnakaran
OBJECTIVE: Women with gestational diabetes mellitus and milder gestational impaired glucose intolerance have elevated future risks of type 2 diabetes and cardiovascular disease. However, it is unclear whether they show postpartum evidence of vascular injury/dysfunction, an early event in the natural history of cardiovascular disease. METHODS: In total, 337 women underwent a glucose challenge test and oral glucose tolerance test in pregnancy, yielding four gestational glucose tolerance groups: gestational diabetes mellitus, gestational impaired glucose intolerance, abnormal glucose challenge test with normal glucose tolerance on the oral glucose tolerance test and normal glucose challenge test with normal glucose tolerance...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29848065/haemoglobin-a1c-variability-as-an-independent-correlate-of-atherosclerosis-and-cardiovascular-disease-in-chinese-type-2-diabetes
#16
Yifei Mo, Jian Zhou, Xiaojing Ma, Wei Zhu, Lei Zhang, Jie Li, Jingyi Lu, Cheng Hu, Yuqian Bao, Weiping Jia
OBJECTIVE: To examine the association between haemoglobin A1c variability and macrovascular complication in type 2 diabetes. METHODS: We retrospectively enrolled 5278 diabetes patients with no history of cardiovascular disease and atherosclerosis by ultrasound at their first visit to the hospital from 1999 to 2010. Patients had a median of 4 haemoglobin A1c (range = 3-9) measurements during follow-up. Average haemoglobin A1c and haemoglobin A1c variability were calculated as intra-individual mean, standard deviation, coefficient of variation and adjusted standard deviation...
May 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29807475/long-term-prospective-observation-suggests-that-glomerular-hyperfiltration-is-associated-with-rapid-decline-in-renal-filtration-function-a-multiethnic-study
#17
Serena Low, Xiao Zhang, Jiexun Wang, Lee Ying Yeoh, Yan Lun Liu, Keven Kue Loong Ang, Wern Ee Tang, Pek Yee Kwan, Subramaniam Tavintharan, Chee Fang Sum, Su Chi Lim
AIM: Glomerular hyperfiltration usually occurs early in development of kidney complications in diabetes. To understand hyperfiltration as a marker of renal disease progression in type 2 diabetes mellitus, we aimed to examine association between glomerular hyperfiltration (estimated glomerular filtration rate ⩾ 120 mL/min/1.73 m2 ) and rapid renal decline (annual estimated glomerular filtration rate loss ⩾ 3 mL/min/1.73 m2 ). METHODS: This was a prospective cohort comprising 1014 patients with type 2 diabetes mellitus attending a Diabetes Centre of a regional hospital in 2002-2014...
May 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29776318/ppard-rs7770619-polymorphism-in-a-korean-population-association-with-plasma-malondialdehyde-and-impaired-fasting-glucose-or-newly-diagnosed-type-2-diabetes
#18
Minjoo Kim, Minkyung Kim, Hye Jin Yoo, Yao Sun, Sang-Hyun Lee, Jong Ho Lee
Both the peroxisome proliferator-activated receptor delta gene ( PPARD) and malondialdehyde plasma concentrations may play a role in impaired glucose metabolism. The aim of this work was to determine whether PPARD is a candidate gene for impaired fasting glucose or type 2 diabetes and whether a particular genetic variant shows association with plasma malondialdehyde levels. Among the 10 single-nucleotide polymorphisms that were most strongly associated with malondialdehyde, the rs7770619 polymorphism in PPARD was analysed in 1798 subjects with normal fasting glucose, impaired fasting glucose and newly diagnosed type 2 diabetes...
May 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29775089/detection-of-perimacular-red-dots-and-blots-when-screening-for-diabetic-retinopathy-refer-or-not-refer
#19
Anatolie Baltatescu, Elio Striglia, Marina Trento, Aurora Mazzeo, Franco Cavallo, Lorena Charrier, Massimo Porta
PURPOSE: Detection of microaneurysms and/or microhaemorrhages near the fovea when screening for diabetic retinopathy poses a problem because referral to retinal specialists may alarm patients and unnecessarily burden ophthalmologists. METHODS: Six-month prospective study of patients found to have minimal red lesions within one disc diameter of the fovea when screened for diabetic retinopathy. Two 45° digital photographs, one centred on the macula and the other nasal including the optic disc, were taken for each eye...
May 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29762054/altered-sarco-endo-plasmic-reticulum-calcium-adenosine-triphosphatase-2a-content-targets-for-heart-failure-therapy
#20
Gang Liu, Si Qi Li, Ping Ping Hu, Xiao Yong Tong
Sarco(endo)plasmic reticulum calcium adenosine triphosphatase is responsible for transporting cytosolic calcium into the sarcoplasmic reticulum and endoplasmic reticulum to maintain calcium homeostasis. Sarco(endo)plasmic reticulum calcium adenosine triphosphatase is the dominant isoform expressed in cardiac tissue, which is regulated by endogenous protein inhibitors, post-translational modifications, hormones as well as microRNAs. Dysfunction of sarco(endo)plasmic reticulum calcium adenosine triphosphatase is associated with heart failure, which makes sarco(endo)plasmic reticulum calcium adenosine triphosphatase a promising target for heart failure therapy...
May 1, 2018: Diabetes & Vascular Disease Research
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