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Diabetes & Vascular Disease Research

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https://www.readbyqxmd.com/read/30428692/association-of-glucagon-to-insulin-ratio-and-nonalcoholic-fatty-liver-disease-in-patients-with-type-2-diabetes-mellitus
#1
Myint Aung Moh Moh, Chan-Hee Jung, Bora Lee, Dughyun Choi, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
OBJECTIVE: The aim of this study is to investigate the association between glucagon-to-insulin ratio and the presence of nonalcoholic fatty liver disease on ultrasonography in participants with type 2 diabetes mellitus. RESEARCH DESIGN AND METHODS: This cross-sectional study was performed with data obtained from 172 participants with type 2 diabetes mellitus admitted to a University hospital of Korea. Participants were assessed for serum fasting and postprandial serum glucagon-to-insulin ratio and divided into tertiles...
November 14, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30426760/description-of-doppler-waveforms-to-detect-lower-extremity-peripheral-artery-disease
#2
Damien Lanéelle, Olivier Stivalet, Guillaume Mahé, Vincent Jaquinandi, Loukman Omarjee
Doppler waveforms analysis is a interesting to diagnose peripheral artery disease as suggested by the international recommendations. However as mentioned in the present letter, there is a lack of consensus about the terminology that should be used.
November 14, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30426758/response-to-the-letter-regarding-description-of-doppler-waveforms-to-detect-lower-extremity-peripheral-artery-disease
#3
Martin Fox, Susan Matthews
Doppler waveforms analysis is a interesting to diagnose peripheral artery disease as suggested by the international recommendations. However as mentioned in the present letter, there is a lack of consensus about the terminology that should be used.
November 14, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30360646/hyperglycaemia-correlates-with-skeletal-muscle-capillary-regression-and-is-associated-with-alterations-in-the-murine-double-minute-2-forkhead-box-o1-thrombospondin-1-pathway-in-type-1-diabetic-biobreeding-rats
#4
Julian Aiken, Erin R Mandel, Michael C Riddell, Olivier Birot
Type 1 diabetes can have deleterious effects on skeletal muscle and its microvasculature. Our laboratory has recently identified murine double minute-2 as a master regulator of muscle microvasculature by controlling expression levels of two key molecular actors of the angio-adaptive process: the pro-angiogenic vascular endothelial growth factor-A and the anti-angiogenic thrombospondin-1. Here, we show for the first time that in the soleus and plantaris muscles of the diabetes-prone BioBreeding rats, a rodent model of autoimmune type 1 diabetes, murine double minute-2 protein levels are significantly decreased, coinciding with elevated protein levels of thrombospondin-1 and its transcription factor forkhead box O1...
October 26, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30345796/generalised-arterial-calcification-in-normoalbuminuric-patients-with-type-1-diabetes-with-and-without-cardiovascular-autonomic-neuropathy
#5
Henrik Øder Hjortkjær, Tonny Jensen, Jannik Hilsted, Ulrik Madvig Mogensen, Peter Rossing, Lars Køber, Klaus Fuglsang Kofoed
BACKGROUND: Type 1 diabetes is associated with increased risk of cardiovascular disease and the diabetic complication cardiovascular autonomic neuropathy in itself entails increased cardiovascular risk by mechanisms not yet fully understood. Arterial calcification is an important predictor of cardiovascular events; the aim of this study was to investigate the level of generalised arterial calcification in patients with long-term, normoalbuminuric type 1 diabetes and the association with cardiovascular autonomic neuropathy, as these factors have not been investigated in type 1 diabetes...
October 20, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30328360/effect-of-12-month-intervention-with-low-dose-atorvastatin-on-pulse-wave-velocity-in-subjects-with-type-2-diabetes-and-dyslipidaemia
#6
Pinelopi Grigoropoulou, Anastasios Tentolouris, Ioanna Eleftheriadou, Dimitrios Tsilingiris, Charalambos Vlachopoulos, Maria Sykara, Nikolaos Tentolouris
Cardiovascular disease is the leading cause of morbidity and mortality in subjects with type 2 diabetes mellitus. Increased aortic stiffness, assessed with the carotid-femoral pulse wave velocity, is an independent risk factor for cardiovascular disease. Statins reduce effectively cardiovascular disease and mortality in high-risk patients. The aim of this prospective non-randomized, observational study was to examine the impact of treatment with either 10 mg atorvastatin plus diet or diet alone on carotid-femoral pulse wave velocity in subjects with type 2 diabetes mellitus and dyslipidaemia...
October 17, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30309264/copeptin-and-insulin-like-growth-factor-binding-protein-1-during-follow-up-after-an-acute-myocardial-infarction-in-patients-with-type-2-diabetes-a-report-from-the-diabetes-mellitus-insulin-glucose-infusion-in-acute-myocardial-infarction-2-cohort
#7
Maria Isabel Smáradóttir, Sergiu-Bogdan Catrina, Kerstin Brismar, Anna Norhammar, Viveca Gyberg, Linda G Mellbin
PURPOSE: Copeptin and insulin-like growth factor binding protein-1 analysed at admission for a myocardial infarction in patients with type 2 diabetes mellitus predicts cardiovascular events. The present aim was to study the association between copeptin and insulin-like growth factor binding protein-1, the development of the levels over time, and if the predictive value remained when measured at hospital discharge and 3 months thereafter. METHODS: Copeptin and insulin-like growth factor binding protein-1 were analysed in patients (median age = 70, male = 68%) with type 2 diabetes mellitus + myocardial infarction at admission (n = 393), discharge (n = 309) and 3 months later (n = 288)...
October 11, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30295509/effects-of-obesity-on-insulin-insulin-like-growth-factor-1-hybrid-receptor-expression-and-akt-phosphorylation-in-conduit-and-resistance-arteries
#8
Romana S Mughal, Katherine Bridge, Irma Buza, Rita Slaaby, Jesper Worm, Gro Klitgaard-Povlsen, Henning Hvid, Marianne Schiødt, Richard Cubbon, Nadira Yuldasheva, Anna Skromna, Natallia Makava, Grith Skytte-Olsen, Mark T Kearney
Insulin and insulin-like growth factor-1 stimulate specific responses in arteries, which may be disrupted by diet-induced obesity. We examined (1) temporal effects of high-fat diet compared to low-fat diet in mice on insulin receptor, insulin-like growth factor-1 receptor, insulin receptor/insulin-like growth factor-1 receptor hybrid receptor expression and insulin/insulin-like growth factor-1-mediated Akt phosphorylation in aorta; and (2) effects of high-fat diet on insulin and insulin-like growth factor-1-mediated Akt phosphorylation and vascular tone in resistance arteries...
October 8, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30284913/retrospective-analysis-of-effects-of-sodium-glucose-co-transporter-2-inhibitor-in-japanese-type-2-diabetes-mellitus-patients-with-chronic-kidney-disease
#9
Kazuo Kobayashi, Masao Toyoda, Moritsugu Kimura, Nobuo Hatori, Takayuki Furuki, Hiroyuki Sakai, Masahiro Takihata, Tomoya Umezono, Shun Ito, Daisuke Suzuki, Hiroshi Takeda, Akira Kanamori, Hisakazu Degawa, Hareaki Yamamoto, Hideo Machimura, Atsuko Mokubo, Keiichi Chin, Mitsuo Obana, Toshimasa Hishiki, Kouta Aoyama, Shinichi Nakajima, Shinichi Umezawa, Hidetoshi Shimura, Togo Aoyama, Kazuyoshi Sato, Masaaki Miyakawa
AIM: The aim of this study was to assess the renal effects of the glucose-lowering SGLT2 inhibitors in Japanese type 2 diabetes mellitus patients with chronic kidney disease. METHODS: The Kanagawa Physicians Association maintains a registry of patients who visit their 31 clinics. Clinical data of type 2 diabetes mellitus patients with chronic kidney disease, who were prescribed SGLT2 inhibitors in addition to other treatments, were collected and analysed. RESULTS: SGLT2i was associated with a fall in HbA1c from 64...
October 4, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30280926/dynamics-of-testosterone-levels-in-patients-with-newly-detected-glucose-abnormalities-and-acute-myocardial-infarction
#10
Anne Wang, Stefan Arver, John Flanagan, Viveca Gyberg, Per Näsman, Viveca Ritsinger, Linda G Mellbin
OBJECTIVE: Low testosterone has been associated with increased cardiovascular risk and glucose abnormalities. This study explored the prevalence of low testosterone, dynamics over time and prognostic implications in acute myocardial infarction patients with or without glucose abnormalities. METHODS: Male acute myocardial infarction patients (n = 123) and healthy controls (n = 124) were categorised as having normal or abnormal glucose tolerance (impaired glucose tolerance or diabetes) by oral glucose tolerance testing...
October 3, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30246546/impact-of-diabetes-type-on-treatment-and-outcome-of-patients-with-peripheral-artery-disease
#11
Lars Richter, Eva Freisinger, Florian Lüders, Katrin Gebauer, Matthias Meyborg, Nasser M Malyar
BACKGROUND: The prevalence of diabetes mellitus and its associated complications such as peripheral artery disease is increasing worldwide. We aimed to explore the distinct impact of type 1 diabetes mellitus and type 2 diabetes mellitus on treatment and on short- and long-term outcome in patients with peripheral artery disease. METHODS: Retrospective analysis of anonymized data of hospitalized patients covered by a large German health insurance. Assessment of patient's characteristics (comorbidities, complications, etc...
September 24, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30238781/guidelines-and-clinical-practice-at-the-primary-level-of-healthcare-in-patients-with-type-2-diabetes-mellitus-with-and-without-kidney-disease-in-five-european-countries
#12
Susanne Eder, Johannes Leierer, Julia Kerschbaum, Laszlo Rosivall, Andrzej Wiecek, Dick de Zeeuw, Patrick B Mark, Georg Heinze, Peter Rossing, Hiddo L Heerspink, Gert Mayer
BACKGROUND: The number of patients with type 2 diabetes mellitus and diabetes mellitus-associated chronic kidney disease varies considerably between countries. Next to differences in genetic as well as life style risk factors, varying practices in medical care delivery might cause this diversity. METHOD: The PROVALID study recruited 4000 patients with type 2 diabetes mellitus at the primary level of healthcare in five European countries (Austria, Hungary, The Netherlands, Poland and Scotland)...
September 21, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30176743/type-2-diabetes-and-heart-failure-characteristics-and-prognosis-in-preserved-mid-range-and-reduced-ventricular-function
#13
Isabelle Johansson, Ulf Dahlström, Magnus Edner, Per Näsman, Lars Rydén, Anna Norhammar
OBJECTIVE: To study the characteristics and prognostic implications of type 2 diabetes in different heart failure entities from a nationwide perspective. METHODS: This observational study comprised 30,696 heart failure patients prospectively included in the Swedish Heart Failure Registry (SwedeHF) 2003-2011 from specialist care, with mortality information available until December 2014. Patients were categorized into three heart failure entities by their left ventricular ejection fraction (heart failure with preserved ejection fraction: ⩾50%, heart failure with mid-range ejection fraction: 40%-49% and heart failure with reduced ejection fraction: <40%)...
September 3, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30175925/optimising-use-of-rate-of-change-trend-arrows-for-insulin-dosing-decisions-using-the-freestyle-libre-flash-glucose-monitoring-system
#14
Ramzi A Ajjan, Michael H Cummings, Peter Jennings, Lalantha Leelarathna, Gerry Rayman, Emma G Wilmot
Continuous glucose monitoring and flash glucose monitoring systems are increasingly used by people with diabetes on multiple daily injections of insulin and continuous subcutaneous insulin infusion. Along with real-time updates on current glucose levels, these technologies also use trend arrows to provide information on the direction and rate of change of glucose. Two systems, the Dexcom G5 and the FreeStyle Libre, have recently been approved for use without the need for adjunct capillary blood glucose, and there is a need for practical guidance for insulin dosing which incorporates rate of change in the insulin dosing algorithm...
September 3, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30160532/blood-adiponectin-levels-are-not-associated-with-risk-of-cardiovascular-events-in-patients-with-type-2-diabetes
#15
Ja Young Jeon, Kyoung Hwa Ha, Seung Jin Han, Hae Jin Kim, Kwan-Woo Lee, Dae Jung Kim
INTRODUCTION: We examined whether circulating adiponectin levels are associated with further cardiovascular events in patients with type 2 diabetes. METHODS: Between December 2004 and February 2005, 349 patients with type 2 diabetes were enrolled and followed-up until December 2015. Blood levels of total, middle-molecular weight and high-molecular weight adiponectin were measured at baseline. The primary composite outcome was the occurrence of the following events: cardiovascular death, non-fatal myocardial infarction, non-fatal stroke or hospitalization for unstable angina and heart failure...
August 30, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30156119/probucol-prevents-blood-brain-barrier-dysfunction-and-cognitive-decline-in-mice-maintained-on-pro-diabetic-diet
#16
John Cl Mamo, Virginie Lam, Emily Brook, Armin Mooranian, Hani Al-Salami, Nicholas Fimognari, Michael Nesbit, Ryusuke Takechi
An emerging body of evidence consistently suggests that compromised blood-brain barrier integrity may be causally associated with cognitive decline induced by type-2 diabetes. Our previous studies demonstrated that selected anti-inflammatory/anti-oxidative agents can preserve the integrity of blood-brain barrier and prevent neuroinflammation in mouse models of dysfunctional blood-brain barrier. Therefore, we have tested whether the previously proven blood-brain barrier protective agent, probucol, can prevent blood-brain barrier breakdown and cognitive decline in a dietary-induced murine model of diabetic insulin resistance...
August 29, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30136860/respond-to-the-letter-on-interobserver-reliability-of-the-ankle-brachial-index-toe-brachial-index-and-distal-pulse-palpation-in-patients-with-diabetes-a-methodological-issue
#17
Francisco Javier Álvaro Afonso, Esther García-Morales, Raúl J Molines-Barroso, Yolanda García-Álvarez, Irene Sanz-Corbalán, José Luis Lázaro-Martínez
We respond to the letter of Nadery and Shahsavari regarding our paper entitled 'Interobserver reliability of the ankle brachial index, toe -brachial index and distal pulse palpation in patients with diabetes. In this letter, we concluded that despite some limitations, the kappa coefficient is an informative measure of agreement in most circumstances that we can use in this type of clinical research.
August 23, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30130976/impaired-vasocontractile-responses-to-adenosine-in-chorionic-vessels-of-human-term-placenta-from-pregnant-women-with-pre-existing-and-gestational-diabetes
#18
Azlina A Razak, Lopa Leach, Vera Ralevic
BACKGROUND: There is clinical and experimental evidence for altered adenosine signalling in the fetoplacental circulation in pregnancies complicated by diabetes, leading to adenosine accumulation in the placenta. However, the consequence for fetoplacental vasocontractility is unclear. This study examined contractility to adenosine of chorionic vessels from type 1 diabetes mellitus, gestational diabetes mellitus and normal pregnancies. METHODS: Chorionic arteries and veins were isolated from human placenta from normal, gestational diabetes mellitus and type 1 diabetes mellitus pregnancies...
August 22, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30415566/primary-vascular-prevention-the-end-of-the-road-for-aspirin
#19
R A Ajjan
No abstract text is available yet for this article.
November 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29992830/elevated-levels-of-insulin-like-growth-factor-binding-protein-1-predict-outcome-after-acute-myocardial-infarction-a-long-term-follow-up-of-the-glucose-tolerance-in-patients-with-acute-myocardial-infarction-gami-cohort
#20
Viveca Ritsinger, Kerstin Brismar, Linda Mellbin, Per Näsman, Lars Rydén, Stefan Söderberg, Anna Norhammar
OBJECTIVE: To investigate the long-term prognostic value of insulin-like growth factor-binding protein 1 in patients with acute myocardial infarction. METHODS: Patients ( n = 180) with admission glucose < 11 mmol/L without previously known diabetes admitted for an acute myocardial infarction in 1998-2000 were followed for mortality and cardiovascular events (first of cardiovascular mortality/acute myocardial infarction/stroke/severe heart failure) until the end of 2011 (median 11...
September 2018: Diabetes & Vascular Disease Research
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