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Diabetes & Vascular Disease Research

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https://www.readbyqxmd.com/read/28631505/methylglyoxal-derived-hydroimidazolone-1-evokes-inflammatory-reactions-in-endothelial-cells-via-an-interaction-with-receptor-for-advanced-glycation-end-products
#1
Yuji Ishibashi, Takanori Matsui, Nobutaka Nakamura, Ami Sotokawauchi, Yuichiro Higashimoto, Sho-Ichi Yamagishi
OBJECTIVE: Glyceraldehyde-derived advanced glycation end products contribute to vascular inflammation in diabetes. However, what advanced glycation end product structure could evoke inflammatory reactions remains unknown. We examined whether and how methylglyoxal-derived hydroimidazolone 1, one of the advanced glycation end products formed from glyceraldehyde, elicits inflammatory reactions in human umbilical vein endothelial cells. MATERIALS AND METHODS: Glyceraldehyde-advanced glycation end products-aptamer was prepared using a systemic evolution of ligands by exponential enrichment...
June 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28631500/pancreatic-%C3%AE-cell-survival-and-proliferation-are-promoted-by-protein-kinase-g-type-i%C3%AE-and-downstream-regulation-of-akt-foxo1
#2
Janica C Wong, Van Vo, Priyatham Gorjala, Ronald R Fiscus
Early studies showed nitric oxide as a pro-inflammatory-cytokine-induced toxin involved in pancreatic β-cell destruction during pathogenesis of type-1 diabetes. However, nitric oxide has both cytotoxic and cytoprotective effects on mammalian cells, depending on concentration and micro-environmental surroundings. Our studies have shown that low/physiological-level nitric oxide selectively activates protein kinase G type Iα isoform, promoting cytoprotective/pro-cell-survival effects in many cell types. In bone marrow-derived stromal/mesenchymal stem cells, protein kinase G type Iα mediates autocrine effects of nitric oxide and atrial natriuretic peptide, promoting DNA-synthesis/proliferation and cell survival...
June 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28610436/obstructive-sleep-apnoea-in-diabetes-does-it-matter
#3
Abd A Tahrani
Obstructive sleep apnoea (OSA) is very common in patients with Type 2 diabetes (T2D), which is not surprising considering that obesity is a common risk factor for both conditions. In general population studies, OSA has been shown to be associated with several comorbidities including increased risk of road traffic accidents, T2D, hypertension and lack of nocturnal dipping of blood pressure, hyperlipidaemia, increased inflammation, increased risk of cardiovascular disease and mortality, increased risk of atrial fibrillation, worse quality of life, and erectile dysfunction...
June 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28595459/percutaneous-closure-of-the-left-atrial-appendage-in-patients-with-diabetes-mellitus
#4
Obayda Azizy, Christos Rammos, Nils Lehmann, Tienush Rassaf, Hagen Kälsch
BACKGROUND: Left atrial appendage closure is a preventive treatment of atrial fibrillation-related thrombo-embolism. Patients with diabetes mellitus have increased risk for a negative outcome in percutaneous cardiac interventions. We assessed whether percutaneous left atrial appendage closure is safe and effective in patients with diabetes mellitus. METHODS: We included 78 patients (mean age of 74.4 ± 8.3 years) with indication for left atrial appendage closure in an open-label observational single-centre study...
June 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28592134/circulating-annexin-a5-levels-are-associated-with-carotid-intima-media-thickness-but-not-coronary-plaque-composition
#5
Mathias Burgmaier, Sebastian Reith, Leon Schurgers, Florian Kahles, Nikolaus Marx, Chris Reutelingsperger
BACKGROUND: Annexin A5 (anxA5) is involved in processes which are crucial in atherogenesis. However, anxA5's relationship with atherosclerotic lesion extension and plaque composition in high-risk patients with type 2 diabetes remains unclear. Thus, we characterized the association between circulating anxA5 levels with atherosclerotic burden and coronary plaque composition in diabetes mellitus patients. METHODS: Intima-media thickness was determined in 96 diabetes mellitus patients with stable coronary artery disease...
June 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28565941/insulin-replacement-limits-progression-of-diabetic-cardiomyopathy-in-the-low-dose-streptozotocin-induced-diabetic-rat
#6
Mitchel Tate, Minh Deo, Anh H Cao, Sally G Hood, Karina Huynh, Helen Kiriazis, Xiao-Jun Du, Tracey L Julius, Gemma A Figtree, Gregory J Dusting, David M Kaye, Rebecca H Ritchie
Diabetic cardiomyopathy is a major contributor to the increasing burden of heart failure globally. Effective therapies remain elusive, in part due to the incomplete understanding of the mechanisms underlying diabetes-induced myocardial injury. The objective of this study was to assess the direct impact of insulin replacement on left ventricle structure and function in a rat model of diabetes. Male Sprague-Dawley rats were administered streptozotocin (55 mg/kg i.v.) or citrate vehicle and were followed for 8 weeks...
May 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28565926/c-peptide-a-predictor-of-cardiovascular-mortality-in-subjects-with-established-atherosclerotic-disease
#7
Marina Cardellini, Alessio Farcomeni, Marta Ballanti, Monica Morelli, Francesca Davato, Iris Cardolini, Giulia Grappasonni, Stefano Rizza, Valeria Guglielmi, Ottavia Porzio, Chiara Pecchioli, Rossella Menghini, Arnaldo Ippoliti, Massimo Federici
AIM: Insulin resistance and type 2 diabetes are independent risk factors for cardiovascular diseases. Levels of C-peptide are increased in these patients and its role in the atherosclerosis progression was studied in vitro and in vivo over the past years. To evaluate the possible use of C-peptide as cardiovascular biomarkers, we designed an observational study in which we enrolled patients with mono- or poly-vascular atherosclerotic disease. METHODS: We recruited 431 patients with stable atherosclerosis and performed a yearly follow-up to estimate the cardiovascular and total mortality and cardiovascular events...
May 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28545328/diabetes-mellitus-increases-the-risk-of-ruptured-abdominal-aortic-aneurysms
#8
Waldemar Wierzba, Andrzej Sliwczynski, Jaroslaw Pinkas, Arkadiusz Jawien, Waldemar Karnafel
The publication is a polemical response to reports that present data that diabetes reduces the risk of rupture of abdominal aortic aneurysm (AAA). The study analyzed all cases of developing AAA in patients with and without diabetes in 2012 in Poland. Data for the analysis were obtained with a unique and complete resources of the National Health Fund (NFZ) and population data from the Central Statistical Office (GUS). In Poland during 2012 2,227,453 patients with diabetes were treated, 975,364 males and 1,252,089 females...
May 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28482676/skin-microvascular-endothelial-dysfunction-is-associated-with-type-2-diabetes-independently-of-microalbuminuria-and-arterial-stiffness
#9
Hanna Jonasson, Sara Bergstrand, Fredrik H Nystrom, Toste Länne, Carl Johan Östgren, Niclas Bjarnegård, Ingemar Fredriksson, Marcus Larsson, Tomas Strömberg
Skin and kidney microvascular functions may be affected independently in diabetes mellitus. We investigated skin microcirculatory function in 79 subjects with diabetes type 2, where 41 had microalbuminuria and 38 not, and in 41 age-matched controls. The oxygen saturation, fraction of red blood cells and speed-resolved microcirculatory perfusion (% red blood cells × mm/s) divided into three speed regions: 0-1, 1-10 and above 10 mm/s, were assessed during baseline and after local heating of the foot with a new device integrating diffuse reflectance spectroscopy and laser Doppler flowmetry...
May 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28429615/regulation-of-vascular-large-conductance-calcium-activated-potassium-channels-by-nrf2-signalling
#10
Yong Li, Xiao-Li Wang, Xiaojing Sun, Qiang Chai, Jingchao Li, Benjamin Thompson, Win-Kuang Shen, Tong Lu, Hon-Chi Lee
BK channels are major ionic determinants of vasodilation. BK channel function is impaired in diabetic vessels due to accelerated proteolysis of its beta-1 (BK-β1) subunits in response to increased oxidative stress. The nuclear factor E2-related factor-2 (Nrf2) signalling pathway has emerged as a master regulator of cellular redox status, and we hypothesized that it plays a central role in regulating BK channel function in diabetic vessels. We found that Nrf2 expression was markedly reduced in db/db diabetic mouse aortas, and this was associated with significant downregulation of BK-β1...
April 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28423914/current-views-on-neuropeptide-y-and-diabetes-related-atherosclerosis
#11
Wei-Wei Sun, Ping Zhu, Yan-Chuan Shi, Chen-Liang Zhang, Xu-Feng Huang, Shi-Yu Liang, Zhi-Yuan Song, Shu Lin
Diabetes-induced atherosclerotic cardiovascular disease is the leading cause of death of diabetic patients. Neuronal regulation plays a critical role in glucose metabolism and cardiovascular function under physiological and pathological conditions, among which, neurotransmitter neuropeptide Y has been shown to be closely involved in these two processes. Elevated central neuropeptide Y level promotes food intake and reduces energy expenditure, thereby increasing adiposity. Neuropeptide Y is co-localized with noradrenaline in central and sympathetic nervous systems...
April 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28403644/the-effect-of-basal-insulin-glargine-on-the-fibrinolytic-system-and-von-willebrand-factor-in-people-with-dysglycaemia-and-high-risk-for-cardiovascular-events-swedish-substudy-of-the-outcome-reduction-with-an-initial-glargine-intervention-trial
#12
Aslak Rautio, Kurt Boman, Hertzel C Gerstein, Jenny Hernestål-Boman, Shun Fu Lee, Mona Olofsson, Linda Garcia Mellbin
INTRODUCTION: Fibrinolytic factors, plasminogen activator inhibitor-1, tissue plasminogen activator, tissue plasminogen activator/plasminogen activator-complex and the haemostatic factor von Willebrand factor are known markers of cardiovascular disease. Their plasma levels are adversely affected in patients with dysglycaemia, and glucose normalization with insulin glargine might improve the levels of these factors. METHODS: Prespecified Swedish substudy of the Outcome Reduction with an Initial Glargine Intervention trial (ClinicalTrials...
April 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28393566/prognostic-implications-of-myocardial-perfusion-imaging-and-coronary-calcium-score-in-a-macedonian-cohort-of-asymptomatic-patients-with-type-2-diabetes
#13
Irena Peovska Mitevska, Natalija Baneva, Elizabeta Srbinovska, Lily Stojanovska, Vasso Apostolopoulos, Marijan Bosevski
AIM: Type 2 diabetes is a risk factor for coronary artery disease; however, a number of studies have shown that patients are asymptomatic for coronary artery disease. The presence of coronary artery disease in asymptomatic patients with type 2 diabetes was evaluated to determine its impact on management decision and prognosis. METHODS: A total of 75 patients underwent single-photon emission computed tomography myocardial perfusion imaging for detection of suspected coronary artery disease...
April 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28393534/the-impact-of-smoking-on-the-development-of-diabetes-and-its-complications
#14
Mariola Śliwińska-Mossoń, Halina Milnerowicz
Diabetes is one of the most common metabolic disorders and emerges secondary to an interaction between genetic, environmental and lifestyle factors. This work provides an overview of the impact of smoking on the development of vascular complications in this condition and also provides an overview of the potential role of smoking in predisposition to diabetes. There are many studies documenting the impact of smoking on health (not focused on patients with diabetes), suggesting that the health exposure in these individuals is at least comparable to that observed in the general population...
April 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28622745/sex-differences-in-vascular-stiffness-and-relationship-to-the-risk-of-renal-functional-decline-in-patients-with-type-2-diabetes
#15
Kenneth A Earle, Lauren Ng, Sarah White, Karima Zitouni
BACKGROUND: Recent data suggest that the higher risk of end-stage renal disease in women compared with men is associated with waist circumference. We investigated whether vascular stiffness which is linked to visceral fat accumulation is gender specific and associated with a loss in renal function. METHODS: We studied 166 patients with type 2 diabetes at high risk of progressive renal disease. A vascular stiffness index was derived from measurement of the peripheral arterial pulse waveform using infrared finger photoplethysmography...
July 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28622744/effects-of-sedentary-occupations-on-type-2-diabetes-and-hypertension-in-different-ethnic-groups-in-north-west-china
#16
Ying Gao, Xiang Xie, Shu-Xia Wang, Hui Li, Han-Zhou Tang, Jing Zhang, Hua Yao
This study investigated the effects of sedentary occupations on type 2 diabetes and hypertension in different ethnic groups in North West China. All subjects were civil servants who received health examinations in the First Affiliated Hospital of Xinjiang Medical University from October 2010 to March 2014. A total of 46,612 participants (39,120 Han, 4148 Uygur, 2098 Hui, 877 Kazak and 369 other ethnicities) completed the examination. Overall, 16.4% of the Han, 14.4% of the Uygur, 15.9% of the Hui, 20.6% of the Kazak and 16...
July 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28622743/endovascular-treatment-for-chronic-lower-extremity-ischaemia-with-sub-acute-deterioration
#17
Liangxi Yuan, Songlin Guo, Jian Dong, Jian Zhou, Qingsheng Lu, Junmin Bao, Zaiping Jing
OBJECTIVES: The purpose of this study is to report the efficacy of endovascular treatment for patients with sub-acute (14-day to 2-month) deterioration of chronic lower extremity ischaemia. MATERIALS AND METHODS: Between June 2013 and May 2015, 26 consecutive patients (22 men, 4 women; mean age, 68.6 years; range, 50-86 years) were treated for sub-acute deterioration of chronic lower extremity ischaemia in our hospital. All patients were treated with catheter-directed thrombolysis initially and then adjunctive percutaneous transluminal angioplasty and/or stenting was performed to correct underlying lesions...
July 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28467203/gaps-and-barriers-in-the-control-of-blood-glucose-in-people-with-type-2-diabetes
#18
Lawrence Blonde, Pablo Aschner, Clifford Bailey, Linong Ji, Lawrence A Leiter, Stephan Matthaei
BACKGROUND: Glycaemic control is suboptimal in a large proportion of people with type 2 diabetes who are consequently at an increased and avoidable risk of potentially severe complications. We sought to explore attitudes and practices among healthcare professionals that may contribute to suboptimal glycaemic control through a review of recent relevant publications in the scientific literature. METHODS: An electronic search of the PubMed database was performed to identify relevant publications from January 2011 to July 2015...
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28467202/a-rationally-designed-peptide-ia-2-p2-against-type-1-diabetes-in-streptozotocin-induced-diabetic-mice
#19
Lili Shen, Shiping Lu, Dongcheng Huang, Guoliang Li, Kunfeng Liu, Rongyue Cao, Li Zong, Liang Jin, Jie Wu
Recent studies have investigated the potential of type 1 diabetes mellitus-related autoantigens, such as heat shock protein 60, to induce immunological tolerance or to suppress the immune response. A functional 24-residue peptide derived from heat shock protein 60 (P277) has shown anti-type 1 diabetes mellitus potential in experimental animals and in clinical studies, but it also carries a potential atherogenic effect. In this study, we have modified P277 to retain an anti-type 1 diabetes mellitus effect and minimize the atherogenic potential by replacing the P277 B epitope with another diabetes-associated autoantigen, insulinoma antigen-2 (IA-2), to create the fusion peptide IA-2-P2...
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28467201/decreased-systolic-blood-pressure-is-associated-with-increased-risk-of-all-cause-mortality-in-patients-with-type-2-diabetes-and-renal-impairment-a-nationwide-longitudinal-observational-study-of-27-732-patients-based-on-the-swedish-national-diabetes-register
#20
Maria K Svensson, Henri Afghahi, Stefan Franzen, Staffan Björk, Soffia Gudbjörnsdottir, Ann-Marie Svensson, Björn Eliasson
BACKGROUND: Previous studies have shown a U-shaped relationship between systolic blood pressure and risk of all-cause of mortality in patients with type 2 diabetes and renal impairment. AIMS: To evaluate the associations between time-updated systolic blood pressure and time-updated change in systolic blood pressure during the follow-up period and risk of all-cause mortality in patients with type 2 diabetes and renal impairment. PATIENTS AND METHODS: A total of 27,732 patients with type 2 diabetes and renal impairment in the Swedish National Diabetes Register were followed for 4...
May 2017: Diabetes & Vascular Disease Research
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