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Diabetes & Vascular Disease Research

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https://www.readbyqxmd.com/read/29776318/ppard-rs7770619-polymorphism-in-a-korean-population-association-with-plasma-malondialdehyde-and-impaired-fasting-glucose-or-newly-diagnosed-type-2-diabetes
#1
Minjoo Kim, Minkyung Kim, Hye Jin Yoo, Yao Sun, Sang-Hyun Lee, Jong Ho Lee
Both the peroxisome proliferator-activated receptor delta gene ( PPARD) and malondialdehyde plasma concentrations may play a role in impaired glucose metabolism. The aim of this work was to determine whether PPARD is a candidate gene for impaired fasting glucose or type 2 diabetes and whether a particular genetic variant shows association with plasma malondialdehyde levels. Among the 10 single-nucleotide polymorphisms that were most strongly associated with malondialdehyde, the rs7770619 polymorphism in PPARD was analysed in 1798 subjects with normal fasting glucose, impaired fasting glucose and newly diagnosed type 2 diabetes...
May 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29775089/detection-of-perimacular-red-dots-and-blots-when-screening-for-diabetic-retinopathy-refer-or-not-refer
#2
Anatolie Baltatescu, Elio Striglia, Marina Trento, Aurora Mazzeo, Franco Cavallo, Lorena Charrier, Massimo Porta
PURPOSE: Detection of microaneurysms and/or microhaemorrhages near the fovea when screening for diabetic retinopathy poses a problem because referral to retinal specialists may alarm patients and unnecessarily burden ophthalmologists. METHODS: Six-month prospective study of patients found to have minimal red lesions within one disc diameter of the fovea when screened for diabetic retinopathy. Two 45° digital photographs, one centred on the macula and the other nasal including the optic disc, were taken for each eye...
May 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29762054/altered-sarco-endo-plasmic-reticulum-calcium-adenosine-triphosphatase-2a-content-targets-for-heart-failure-therapy
#3
Gang Liu, Si Qi Li, Ping Ping Hu, Xiao Yong Tong
Sarco(endo)plasmic reticulum calcium adenosine triphosphatase is responsible for transporting cytosolic calcium into the sarcoplasmic reticulum and endoplasmic reticulum to maintain calcium homeostasis. Sarco(endo)plasmic reticulum calcium adenosine triphosphatase is the dominant isoform expressed in cardiac tissue, which is regulated by endogenous protein inhibitors, post-translational modifications, hormones as well as microRNAs. Dysfunction of sarco(endo)plasmic reticulum calcium adenosine triphosphatase is associated with heart failure, which makes sarco(endo)plasmic reticulum calcium adenosine triphosphatase a promising target for heart failure therapy...
May 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29682995/efficacy-and-safety-of-the-combination-of-isosorbide-dinitrate-spray-and-chitosan-gel-for-the-treatment-of-diabetic-foot-ulcers-a-double-blind-randomized-clinical-trial
#4
Sylvia Elena Totsuka Sutto, Yunuen Itzet Rodríguez Roldan, Ernesto German Cardona Muñoz, Teresa Arcelia Garcia Cobian, Sara Pascoe Gonzalez, Abril Martínez Rizo, Miriam Mendez Del Villar, Leonel García Benavides
AIM: To evaluate whether a combination of isosorbide dinitrate spray and chitosan gel (10%) topically applied can have additive benefits for management of diabetic foot ulcers. METHODS: In a randomized, placebo-controlled, double-blinded clinical trial, 68 patients were divided into four groups: Group 1: treated with chitosan gel; Group 2: isosorbide dinitrate spray; Group 3: combination of isosorbide dinitrate spray and chitosan gel; Group 4: placebo. RESULTS: Histological analyses showed a significant regeneration in all groups ( p < 0...
April 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29676604/is-diabetes-a-marker-of-higher-risk-after-carotid-revascularization-experience-from-a-single-centre
#5
Renato Casana, Chiara Malloggi, Andrea Odero, Valerio Tolva, Richard Bulbulia, Alison Halliday, Vincenzo Silani
PURPOSE: This single centre study investigates the influence of diabetes mellitus on outcomes following carotid artery endarterectomy or stenting. METHODS: In total, 752 carotid revascularizations (58.2% carotid artery stenting and 41.8% carotid endarterectomy) were performed in 221 (29.4%) patients with diabetes and 532 (70.6%) patients without diabetes. The study outcomes were death, disabling and non-disabling stroke, transient ischaemic attack and restenosis within 36 months after the procedure...
April 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29637790/interobserver-reliability-of-the-ankle-brachial-index-toe-brachial-index-and-distal-pulse-palpation-in-patients-with-diabetes
#6
Francisco Javier Álvaro-Afonso, Esther García-Morales, Raúl J Molines-Barroso, Yolanda García-Álvarez, Irene Sanz-Corbalán, José Luis Lázaro-Martínez
OBJECTIVE: We conducted a prospective pilot study in patients with diabetes to analyse the interobserver reliability of the ankle-brachial index, toe-brachial index and distal pulse palpation depending on the training of the professional involved. MATERIALS AND METHODS: The ankle-brachial index, toe-brachial index and distal pulses were assessed by three clinicians with different levels of experience on the same day. Measurements were supervised and recorded by a fourth clinician...
April 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29558826/diabetes-mellitus-secondary-to-pancreatic-diseases-type-3c-the-effect-of-smoking-on-the-exocrine-endocrine-interactions-of-the-pancreas
#7
Mariola Śliwińska-Mossoń, Stanisław Milnerowicz, Halina Milnerowicz
The present study was conducted to ascertain how cigarette smoke affects the exocrine-endocrine interactions of the human pancreas with diabetes mellitus secondary to pancreatic diseases (type 3c). Blood has been collected from smoking and non-smoking healthy individuals as well as from patients with diagnosed chronic pancreatitis and diabetes type 3c. The concentrations of interleukin-6, endothelin-1 and insulin in the plasma were determined by enzyme-linked immunosorbent assay (ELISA) tests. The activities of amylase and lipase in the serum, as well as the lipid profile, creatinine, uric acid and urea concentrations, were measured using colorimetric methods...
March 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29543038/association-of-serum-c1q-tumour-necrosis-factor-related-protein-9-with-the-severity-of-lower-extremity-peripheral-arterial-disease-in-type-2-diabetes-patients
#8
Wengao Jiang, Qiang Tang, Lei Zhang, Yinxue Chao, Bing Hong
OBJECTIVE: Recent studies have indicated the implication of C1q tumour necrosis factor-related protein 9 in vascular pathology of atherosclerosis. This study first investigated the association of C1q tumour necrosis factor-related protein 9 and the severity of lower extremity peripheral arterial disease in type 2 diabetes mellitus patients. METHODS: A total of 200 patients with type 2 diabetes mellitus had ankle-brachial index examined in this cross-sectional study, 60 patients with ankle-brachial index of ⩽0...
March 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29499628/in-vivo-inhibition-of-nuclear-factor-of-activated-t-cells-leads-to-atherosclerotic-plaque-regression-in-igf-ii-ldlr-apob-100-100-mice
#9
Fabiana Blanco, Suvi E Heinonen, Erika Gurzeler, Lisa M Berglund, Anna-Maria Dutius Andersson, Olga Kotova, Ann-Cathrine Jönsson-Rylander, Seppo Ylä-Herttuala, Maria F Gomez
AIMS: Despite vast clinical experience linking diabetes and atherosclerosis, the molecular mechanisms leading to accelerated vascular damage are still unclear. Here, we investigated the effects of nuclear factor of activated T-cells inhibition on plaque burden in a novel mouse model of type 2 diabetes that better replicates human disease. METHODS & RESULTS: IGF-II/LDLR-/- ApoB100/100 mice were generated by crossbreeding low-density lipoprotein receptor-deficient mice that synthesize only apolipoprotein B100 (LDLR-/- ApoB100/100 ) with transgenic mice overexpressing insulin-like growth factor-II in pancreatic β cells...
March 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29498294/asymmetric-dimethylarginine-levels-and-diabetes-duration-relationship-with-measures-of-subclinical-atherosclerosis-and-cardiac-function-in-children-and-adolescents-with-type-1-diabetes
#10
Betül Ersoy, Nilgün Eroğlu, Mecnun Çetin, Ece Onur, Mine Özkol, Şenol Coşkun
AIMS: We aimed to evaluate asymmetric dimethylarginine levels in young patients with Type 1 diabetes mellitus according to diabetes duration and to examine the relationship between these levels and measures of atherosclerosis and myocardial function. MATERIALS AND METHODS: In total, 83 patients (8.5-22 years) with Type 1 diabetes mellitus were stratified by diabetes duration: 12-60 months (Group 1, n = 27), >60-120 months (Group 2, n = 29) and >120 months (Group 3, n = 27)...
May 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29488397/long-term-changes-in-retinal-vascular-diameter-and-cognitive-impairment-in-type-1-diabetes
#11
Karen A Nunley, Andrea L Metti, Ronald Klein, Barbara E Klein, Judith A Saxton, Trevor J Orchard, Tina Costacou, Howard J Aizenstein, Caterina Rosano
OBJECTIVE: To assess associations between cognitive impairment and longitudinal changes in retinal microvasculature, over 18 years, in adults with type 1 diabetes. RESEARCH DESIGN AND METHODS: Participants of the Pittsburgh Epidemiology of Diabetes Complications Study received ≥3 fundus photographs between baseline (1986-1988) and time of cognitive assessment (2010-2015: N = 119; 52% male; mean age and type 1 diabetes duration 43 and 34 years, respectively). Central retinal arteriolar equivalent and central retinal venular equivalent were estimated via computer-based methods; overall magnitude and speed of narrowing were quantified as cumulative average and slope, respectively...
May 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29466880/telmisartan-reverses-antiretroviral-induced-adipocyte-toxicity-and-insulin-resistance-in-vitro
#12
Sudeep P Pushpakom, Antonysunil Adaikalakoteswari, Andrew Owen, David J Back, Gyanendra Tripathi, Sudhesh Kumar, Philip McTernan, Munir Pirmohamed
BACKGROUND: Antiretroviral therapy in HIV-positive patients leads to insulin resistance which is central to the pathogenesis of various metabolic abnormalities and cardiovascular disease seen in this patient group. We have investigated the dose-response relationship of telmisartan, an antihypertensive, on adipocytes in vitro in order to determine whether it may have metabolic beneficial effects. METHODS: Using in vitro chronic toxicity models (3T3-F442A murine and primary human adipocytes), we evaluated the effects of different concentrations of telmisartan on adipocyte differentiation and adipogenic gene expression using lipid accumulation assays and real-time polymerase chain reaction, respectively...
May 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29338326/diabetes-mellitus-and-atrial-remodelling-in-patients-with-paroxysmal-atrial-fibrillation-role-of-electroanatomical-mapping-and-catheter-ablation
#13
Domenico Grieco, Zefferino Palamà, Alessio Borrelli, Ermenegildo De Ruvo, Luigi Sciarra, Antonio Scarà, Emilia Goanta, Vito Calabrese, Paolo Pozzilli, Germano Di Sciascio, Leonardo Calò
Complex fractionated atrial electrograms (CFAEs) are related to atrial fibrosis, but their ablation has not yet shown superiority. The aim of the study was to compare, in terms of clinical outcome, two strategies of paroxysmal atrial fibrillation (AF) ablation in patients with type 1 diabetes mellitus (DM): pulmonary vein isolation (PVI) vs. PVI + CFAEs. Compared to an historical population of patient with paroxysmal AF and without DM, a higher percentage of patients with DM showed more than 25% of atrial area interested by CFAEs (study population, 58% vs historical group, 15%; p < 0...
May 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29283006/regional-arterial-stiffness-in-central-and-peripheral-arteries-is-differentially-related-to-endothelial-dysfunction-assessed-by-brachial-flow-mediated-dilation-in-metabolic-syndrome
#14
Smriti Badhwar, Dinu S Chandran, Ashok Kumar Jaryal, Rajiv Narang, Kishore Kumar Deepak
The interrelationship between endothelial function and arterial stiffness may be different for central and peripheral arteries due to their structural and functional differences. The study aims to assess the interrelationship between central and peripheral vascular function and haemodynamics in metabolic syndrome. Thirty-seven patients [63.0 (57.5-66.0) years, 68.4% males] of metabolic syndrome (National Cholesterol Education Program - Adult Treatment Panel-III criteria) were studied. Carotid-femoral, carotid-radial pulse wave velocity and augmentation index (AIx @75) were assessed using applanation tonometry...
March 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29237301/response-to-letter-to-the-editor-entitled-correct-microarray-analysis-approaches-in-hsa-circrna11783-2-in-peripheral-blood-is-correlated-with-coronary-artery-disease-and-type-2-diabetes-mellitus
#15
Zhenzhou Zhao, Xuejie Li, Muwei Li
In the paper entailed 'Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus', we illustrated the correlation of circRNA with T2DM and CAD. We used the common method - Q-PCR to select differentially expressed circular RNA (differentially expressedgenes(DEGs)), with a criteria of fold change>2 and unadjusted p values < 0.05 in expression. When the candidate RNAs have been narrowed down by GO and Pathway analysis, Q-PCR is a good verification method, although the idea that using Q-PCR to verify all the DEGs is still unrealistic...
March 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29233018/type-1-diabetic-patients-have-better-endothelial-function-after-simultaneous-pancreas-kidney-transplantation-than-after-kidney-transplantation-with-continued-insulin-therapy
#16
Jacek Ziaja, Adrian P Kowalik, Aureliusz Kolonko, Dorota Kamińska, Aleksander J Owczarek, Agata Kujawa-Szewieczek, Mariusz A Kusztal, Joanna Badura, Dominika Bożek-Pająk, Piotr Choręza, Agnieszka Zakrzewska, Robert Król, Stefan Chłopicki, Marian Klinger, Andrzej Więcek, Jerzy Chudek, Lech Cierpka
The purpose of this study was to analyse the influence of simultaneous pancreas-kidney or kidney transplantation on endothelial function and systemic inflammation in type 1 diabetic patients with end-stage renal disease. In 39 simultaneous pancreas-kidney, 39 type 1 diabetic kidney and 52 non-diabetic kidney recipients, flow-mediated dilatation was measured. Additionally, blood glycated haemoglobin, serum creatinine and lipids, plasma nitrites [Formula: see text] and nitrates, asymmetric dimethylarginine, soluble vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and E-selectin, high-sensitivity C-reactive protein, tumour necrosis factor-α, interleukin 1β and interleukin 6 concentrations were assessed...
March 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29233017/sos1-gene-polymorphisms-are-associated-with-gestational-diabetes-mellitus-in-a-chinese-population-results-from-a-nested-case-control-study-in-taiyuan-china
#17
Qiong Chen, Hailan Yang, Yongliang Feng, Ping Zhang, Weiwei Wu, Shuzhen Li, Brian Thompson, Xin Wang, Tingting Peng, Fang Wang, Bingjie Xie, Pengge Guo, Mei Li, Ying Wang, Nan Zhao, Suping Wang, Yawei Zhang
Gestational diabetes mellitus is a growing public health concern due to its large disease burden; however, the underlying pathophysiology remains unclear. Therefore, we examined the relationship between 107 single-nucleotide polymorphisms in insulin signalling pathway genes and gestational diabetes mellitus risk using a nested case-control study. The SOS1 rs7598922 GA and AA genotype were statistically significantly associated with reduced gestational diabetes mellitus risk ( ptrend  = 0.0006) compared with GG genotype...
March 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29233016/the-association-between-the-metabolic-syndrome-and-metabolic-syndrome-score-and-pulmonary-function-in-non-smoking-adults
#18
Hyun Yoon, Mi Young Gi, Ju Ae Cha, Chan Uk Yoo, Sang Muk Park
OBJECTIVE: This study assessed the association of metabolic syndrome and metabolic syndrome score with the predicted forced vital capacity and predicted forced expiratory volume in 1 s (predicted forced expiratory volume in 1 s) values in Korean non-smoking adults. METHODS: We analysed data obtained from 6684 adults during the 2013-2015 Korean National Health and Nutrition Examination Survey. RESULTS: After adjustment for related variables, metabolic syndrome ( p < 0...
March 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29212365/impact-of-metabolic-control-on-macular-thickness-in-diabetic-macular-oedema
#19
Yi-Jie Peng, Meng-Ju Tsai
PURPOSE: To investigate the impact of metabolic control on macular thickness measured using optical coherence tomography in patients with diabetic retinopathy with or without macular oedema. METHODS: A total of 124 patients with diabetic retinopathy ( n = 70 without macular oedema and n = 54 with macular oedema) were enrolled. Optical coherence tomography parameters measured included central macular thickness and total macular volume. Metabolic factors with correlation to optical coherence tomography parameters were fasting plasma glucose, glycosylated haemoglobin, triglyceride, low-density lipoprotein and estimated glomerular filtration rate...
March 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29205066/an-analysis-of-barriers-to-entry-of-cardiac-rehabilitation-in-patients-with-diabetes-using-data-from-the-national-audit-of-cardiac-rehabilitation
#20
Alexander S Harrison, Patrick Doherty, Anne Phillips
BACKGROUND: UK cardiac rehabilitation has reached for the first time 50% uptake in 2016; however, this still leaves 50% of the eligible group not starting cardiac rehabilitation. The characteristics of patients missing cardiac rehabilitation are relatively unknown with some studies in America suggesting that patients with diabetes have a reduced likelihood of joining cardiac rehabilitation. METHODS: This study used routinely collected data from the National Audit of Cardiac Rehabilitation to investigate proportional differences in patients with cardiovascular disease with, and without, diabetes taking up the offer of cardiac rehabilitation...
March 2018: Diabetes & Vascular Disease Research
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