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Diabetes & Vascular Disease Research

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https://www.readbyqxmd.com/read/29153006/effect-of-bariatric-surgery-on-diabetic-nephropathy-in-obese-type-2-diabetes-patients-in-a-retrospective-2-year-study-a-local-pilot
#1
Anthony Tl Chao, Sum Chee Fang, Benjamin Cc Lam, Anton Ks Cheng, Serena Km Low, Lim Su Chi
PURPOSE: To determine the effects of bariatric surgery on albuminuria in obese patients with type 2 diabetes mellitus. METHODS: Retrospective analyses of clinical records of obese patients with type 2 diabetes mellitus who had either micro- or macroalbuminuria and had undergone various bariatric surgery were retrieved from a local hospital database. Their clinical data from follow-up appointments including albuminuria were analysed. RESULTS: Of the 46 subjects with type 2 diabetes mellitus, 15 subjects had diabetic nephropathy and had pre- and post-bariatric surgery urine albumin-to-creatinine ratio or urine protein-to-creatinine ratio data available for analysis; 13 out of the 15 subjects (86...
November 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29119826/comment-to-regarding-diabetes-mellitus-increases-the-risk-of-ruptured-abdominal-aortic-aneurysms
#2
Waldemar Wierzba, Andrzej Sliwczynski, Jaroslaw Pinkas, Arkadiusz Jawien, Waldemar Karnafel
This publication is a commentary on the Letter to the Editor by Juliette Raffort and Fabien Lareyre. This article clarifies a number of concerns about the method of calculating the index of prevalence of ruptured abdominal aortic aneurysms (AAA). The method of qualifying patients for the study and the method of calculating the index of prevalence of ruptured AAA in cohorts of diabetic and non-diabetic patients was presented. Most researchers calculate the Index of Prevalence per 100,000 of the general population...
November 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29113512/diabetes-based-on-2-h-plasma-glucose-among-those-classified-as-having-prediabetes-based-on-fasting-plasma-glucose-or-a1c
#3
Andy Menke, Keith F Rust, Catherine C Cowie
OBJECTIVE: Determine the prevalence of diabetes using 2-h plasma glucose among people who otherwise would be categorized as having prediabetes based on A1c and fasting glucose, and to determine whether those people were more likely to have cardiometabolic risk factors. METHODS: Among 3644 adults with prediabetes based on A1c and fasting glucose in the 2005-2014 National Health and Nutrition Examination Survey, a cross-sectional survey of the US general population, we estimated the percentage who would be categorized as having diabetes based on having a 2-h plasma glucose ⩾200 mg/dL...
November 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29113510/interrelationship-of-canonical-and-non-canonical-wnt-signalling-pathways-in-chronic-metabolic-diseases
#4
Ian Ackers, Ramiro Malgor
Chronic diseases account for approximately 45% of all deaths in developed countries and are particularly prevalent in countries with the most sophisticated and robust public health systems. Chronic metabolic diseases, specifically lifestyle-related diseases pertaining to diet and exercise, continue to be difficult to treat clinically. The most prevalent of these chronic metabolic diseases include obesity, diabetes, non-alcoholic fatty liver disease, chronic kidney disease and cardiovascular disease and will be the focus of this review...
November 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29113459/the-combined-effect-of-vitamin-d-and-parathyroid-hormone-concentrations-on-glucose-homeostasis-in-older-patients-with-prediabetes-a-cross-sectional-study
#5
Spyridon N Karras, Panagiotis Anagnostis, Vasiliki Antonopoulou, Xanthippi Tsekmekidou, Theocharis Koufakis, Dimitrios G Goulis, Pantelis Zebekakis, Kalliopi Kotsa
BACKGROUND: The combined effect of vitamin D and parathyroid hormone on glucose homeostasis has not been adequately investigated. The aim of this study was to examine the role of parathyroid hormone/vitamin D axis on glucose homeostasis in elderly persons with prediabetes. METHODS: Patients with prediabetes ( n = 144) and healthy age-matched controls ( n = 81) were included in this cross-sectional study. Study parameters included anthropometric characteristics, morning fasting glucose (fasting plasma glucose), insulin (fasting plasma insulin), parathyroid hormone, 25-hydroxyvitamin D, homeostasis model assessment of insulin resistance and homeostasis model assessment of β-cell function...
November 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29108424/correct-microarray-analysis-approaches-in-hsa-circrna11783-2-in-peripheral-blood-is-correlated-with-coronary-artery-disease-and-type-2-diabetes-mellitus
#6
Chenyu Li, Long Zhao, Wei Jiang, Lin Che, Yan Xu
We read with great interest the article by Li et al. The results are illuminating for understanding the relationship among Hsa-circRNA11783-2, coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM). However, from our perspective, the bioinformatics analyses need further context as the statistics for differential fold changes in expression data are not explained fully. The authors seem to use unadjusted p values for detecting differentially expressed circular RNA (differentially expressed genes (DEGs)) between the control, CAD and T2DM group...
November 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29090609/serum-cystatin-c-is-associated-with-subclinical-atherosclerosis-in-patients-with-type-2-diabetes-a-retrospective-study
#7
Yu Kyung Chung, Young Ju Lee, Kye Whon Kim, Ryu Kyoung Cho, Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
BACKGROUND: The aim of this study was to investigate the association between the serum cystatin C level and cardiovascular disease risk in patients with type 2 diabetes mellitus. METHODS: We studied 523 patients with type 2 diabetes mellitus and calculated estimated 10-year risk of atherosclerotic cardiovascular disease (%). Subclinical atherosclerosis was defined as brachial-ankle pulse wave velocity ⩾1700 ms, indicating the presence of arterial stiffness. RESULTS: Cystatin C level was significantly higher in the subclinical atherosclerosis group (brachial-ankle pulse wave velocity ⩾ 1700 ms) than in the non-subclinical atherosclerosis group (brachial-ankle pulse wave velocity < 1700 ms) (7...
October 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29081239/association-between-1-h-post-load-plasma-glucose-levels-and-arterial-stiffness-in-normotensive-subjects-with-normal-glucose-tolerance
#8
Atsushi Nakagomi, Yuko Sunami, Sho Okada, Yuji Ohno, Toshihiro Shoji, Takehiko Fujisawa, Yoshio Kobayashi
OBJECTIVE: To investigate the relationship between 1-h post-load plasma glucose, measured during an oral glucose tolerance test, and arterial stiffness, determined by brachial-ankle pulse-wave velocity, in normotensive subjects with normal glucose tolerance. METHODS: Study subjects were non-industrial workers aged 25-55 years ( n = 8381) who underwent a regular health check-up every 5 years. We included only normotensive subjects with normal glucose tolerance based on the American Diabetes Association criteria...
October 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29081238/regarding-diabetes-mellitus-increases-the-risk-of-ruptured-abdominal-aortic-aneurysms
#9
Juliette Raffort, Fabien Lareyre
Abdominal aortic aneurysm (AAA) is a life-threatening disease, associated with high rates of mortality in case of aortic rupture. While the disease is often associated with atherosclerosis and cardiovascular risk factors, the majority of epidemiological studies published so far have highlighted a negative association between diabetes and AAA. However, a recent publication from epidemiological data of the National Health Fund in Poland reported a higher incidence of AAA and rupture in diabetic patients compared to non-diabetics...
October 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29052439/predictors-of-mortality-in-hospital-survivors-with-type-2-diabetes-mellitus-and-acute-coronary-syndromes
#10
Stefano Savonitto, Nuccia Morici, Anna Nozza, Francesco Cosentino, Pasquale Perrone Filardi, Ernesto Murena, Giorgio Morocutti, Marco Ferri, Claudio Cavallini, Marinus Jc Eijkemans, Barbara E Stähli, Ilse C Schrieks, Tadashi Toyama, H J Lambers Heerspink, Klas Malmberg, Gregory G Schwartz, A Michael Lincoff, Lars Ryden, Jean Claude Tardif, Diederick E Grobbee
AIM: To define the predictors of long-term mortality in patients with type 2 diabetes mellitus and recent acute coronary syndrome. METHODS AND RESULTS: A total of 7226 patients from a randomized trial, testing the effect on cardiovascular outcomes of the dual peroxisome proliferator-activated receptor agonist aleglitazar in patients with type 2 diabetes mellitus and recent acute coronary syndrome (AleCardio trial), were analysed. Median follow-up was 2 years. The independent mortality predictors were defined using Cox regression analysis...
October 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29052435/high-overall-cardiovascular-risk-and-mortality-in-patients-with-atrial-fibrillation-and-diabetes-a-nationwide-report
#11
Stelios Karayiannides, Pia Lundman, Leif Friberg, Anna Norhammar
AIM: To describe nationwide complication patterns in patients with atrial fibrillation and diabetes mellitus. METHODS: All ( n = 326,832) patients in Sweden with non-valvular atrial fibrillation during 2006-2012 were identified, and information on events, comorbidities and pharmacological therapy was extracted using nationwide mandatory registers. Patients were followed until 31 December 2013 and the mean follow-up time was 3.7 years (0.9-8 years). RESULTS: Diabetes was present in 17...
October 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29027826/dietary-advanced-glycated-end-products-and-medicines-influence-the-expression-of-sirt1-and-ddost-in-peripheral-mononuclear-cells-from-long-term-type-1-diabetes-patients
#12
Daniele P Santos-Bezerra, Adriana Machado-Lima, Maria Beatriz Monteiro, Sharon N Admoni, Ricardo V Perez, Cleide G Machado, Maria Heloíza Shimizu, Ana M Cavaleiro, Karina Thieme, Márcia S Queiroz, Ubiratan F Machado, Daniel Giannella-Neto, Marisa Passarelli, Maria Lúcia Corrêa-Giannella
Quantitative polymerase chain reaction was employed to quantify expression of two genes coding for advanced glycation end-product receptors [RAGE ( AGER) and AGER1 ( DDOST)] and of the gene coding the deacetylase SIRT1 ( SIRT1) in peripheral blood mononuclear cells from type 1 diabetes patients without [Group A, n = 35; 28.5 (24-39) years old; median (interquartile interval)] or with at least one microvascular complication [Group B, n = 117; 34.5 (30-42) years old]; 31 healthy controls were also included. In a subgroup of 48 patients, daily advanced glycation end-products intake before blood collection was assessed...
October 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28976221/dapagliflozin-attenuates-human-vascular-endothelial-cell-activation-and-induces-vasorelaxation-a-potential-mechanism-for-inhibition-of-atherogenesis
#13
Tracey Gaspari, Iressa Spizzo, HongBin Liu, Yunshan Hu, Richard W Simpson, Robert E Widdop, Anthony E Dear
BACKGROUND: Sodium glucose transporter type 2 inhibitors may reduce cardiovascular events in type 2 diabetes. Our study aimed to determine the effect of the sodium glucose transporter type 2 inhibitor dapagliflozin on endothelial cell activation, vasoreactivity and atherogenesis using in vitro and in vivo models and identify associated molecular mechanisms. METHODS: In vitro studies utilised human vascular endothelial cells stimulated with tumour necrosis factor α or hyperglycaemic conditions...
October 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28976207/metabolomic-profile-of-arterial-stiffness-in-aged-adults
#14
Angela S Koh, Fei Gao, Jin Liu, Kevin Timothy Fridianto, Jianhong Ching, Ru San Tan, Jia-Ing Wong, Serene Jm Chua, Shuang Leng, Liang Zhong, Bryan Mh Keng, Fei Qiong Huang, Jian-Min Yuan, Woon-Puay Koh, Jean-Paul Kovalik
BACKGROUND: Increasing arterial stiffness is an important contributor to declining cardiovascular health in ageing. Changes in whole-body fuel metabolism could be related to alterations in arterial stiffness in ageing adults. METHODS: Targeted high-performance liquid and gas chromatography mass spectrometry were used to measure 84 circulating metabolites in a group of community elderly adults ( n = 141, 58% men; mean age = 70.6 ± 11.2 years) without cardiovascular disease...
October 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28931323/near-infrared-spectroscopy-can-detect-differences-in-vascular-responsiveness-to-a-hyperglycaemic-challenge-in-individuals-with-obesity-compared-to-normal-weight-individuals
#15
Rogério Nogueira Soares, Raylene A Reimer, Zaid Alenezi, Patricia K Doyle-Baker, Juan Manuel Murias
OBJECTIVE: To examine whether the near-infrared spectroscopy combined with vascular occlusion test technique could detect differences in vascular responsiveness during hyperglycaemia between normal-weight individuals and individuals with obesity. METHODS: A total of 16 normal-weight individuals (body mass index, 21.3 ± 1.7 kg/m(2)) and 13 individuals with obesity (body mass index, 34.4 ± 2.0 kg/m(2)) were submitted to five vascular occlusion tests (Pre, 30, 60, 90 and 120 min after glucose challenge)...
September 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28866908/high-burden-of-coronary-atherosclerosis-in-patients-with-a-new-diagnosis-of-type-2-diabetes
#16
Monija Mrgan, Kristian L Funck, Sara Gaur, Kristian A Øvrehus, Damini Dey, Martin W Kusk, Bjarne L Nørgaard, Jørgen B Gram, Michael H Olsen, Jeppe Gram, Niels Peter R Sand
PURPOSE: The purposes of this study were to compare the presence, extent and composition of coronary plaques in asymptomatic patients with newly diagnosed type 2 diabetes to age- and sex-matched controls. METHODS: Patients with newly diagnosed (<1 year) type 2 diabetes ( n = 44) and controls ( n = 44) underwent contrast-enhanced coronary computed tomography angiography. Advanced plaque analysis including total plaque volume and volumes of plaque components (calcified plaque and non-calcified plaque, including low-attenuation [low-density non-calcified plaque]) was performed using validated semi-automated software...
September 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29050503/reticulated-platelets-in-poorly-controlled-diabetes-a-new-era-in-the-management-of-residual-risk
#17
Peter J Grant
No abstract text is available yet for this article.
November 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28868898/the-tumour-suppressor-cdkn2a-p16-ink4a-regulates-adipogenesis-and-bone-marrow-dependent-development-of-perivascular-adipose-tissue
#18
Kristiaan Wouters, Yann Deleye, Sarah A Hannou, Jonathan Vanhoutte, Xavier Maréchal, Augustin Coisne, Madjid Tagzirt, Bruno Derudas, Emmanuel Bouchaert, Christian Duhem, Emmanuelle Vallez, Casper G Schalkwijk, François Pattou, David Montaigne, Bart Staels, Réjane Paumelle
The genomic CDKN2A/B locus, encoding p16(INK4a) among others, is linked to an increased risk for cardiovascular disease and type 2 diabetes. Obesity is a risk factor for both cardiovascular disease and type 2 diabetes. p16(INK4a) is a cell cycle regulator and tumour suppressor. Whether it plays a role in adipose tissue formation is unknown. p16(INK4a) knock-down in 3T3/L1 preadipocytes or p16(INK4a) deficiency in mouse embryonic fibroblasts enhanced adipogenesis, suggesting a role for p16(INK4a) in adipose tissue formation...
November 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28830235/endothelial-cell-apoptosis-correlates-with-low-haptoglobin-concentrations-in-diabetes
#19
Rinkoo Dalan, Xiaofeng Liu, Liuh Ling Goh, Sun Bing, Kathy Qian Luo
OBJECTIVE: The haptoglobin 2-2 genotype is associated with lower haptoglobin concentrations and atherosclerosis in diabetes. Endothelial cell apoptosis contributes significantly to atherosclerosis. We studied endothelial cell apoptosis in diabetes patients with haptoglobin 2-2 and non-haptoglobin 2-2 genotype. Approach and results: We pooled plasma from 10 patients with haptoglobin 2-2 and non-haptoglobin 2-2 genotype and quantified endothelial cell apoptosis using a hemodynamic lab-on-chip system...
November 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28777011/hsa-circrna11783-2-in-peripheral-blood-is-correlated-with-coronary-artery-disease-and-type-2-diabetes-mellitus
#20
Xuejie Li, Zhenzhou Zhao, Dongdong Jian, Wentao Li, Haiyu Tang, Muwei Li
OBJECTIVE: The purpose of this study was to identify the expression characteristics of circular RNAs in the peripheral blood of coronary artery disease patients and type 2 diabetes mellitus patients. METHODS: Circular RNA in the peripheral blood from 6 control individuals, 6 coronary artery disease patients, 6 type 2 diabetes mellitus patients and 6 coronary artery disease combined with type 2 diabetes mellitus patients was collected for microarray analysis, and a further independent cohort consisting of 20 normal individuals, 20 type 2 diabetes mellitus subjects and 20 coronary artery disease subjects was used to verify the expression of five circular RNAs chosen for further analysis...
November 2017: Diabetes & Vascular Disease Research
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