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Diabetes & Vascular Disease Research

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https://www.readbyqxmd.com/read/28482676/skin-microvascular-endothelial-dysfunction-is-associated-with-type-2-diabetes-independently-of-microalbuminuria-and-arterial-stiffness
#1
Hanna Jonasson, Sara Bergstrand, Fredrik H Nystrom, Toste Länne, Carl Johan Östgren, Niclas Bjarnegård, Ingemar Fredriksson, Marcus Larsson, Tomas Strömberg
Skin and kidney microvascular functions may be affected independently in diabetes mellitus. We investigated skin microcirculatory function in 79 subjects with diabetes type 2, where 41 had microalbuminuria and 38 not, and in 41 age-matched controls. The oxygen saturation, fraction of red blood cells and speed-resolved microcirculatory perfusion (% red blood cells × mm/s) divided into three speed regions: 0-1, 1-10 and above 10 mm/s, were assessed during baseline and after local heating of the foot with a new device integrating diffuse reflectance spectroscopy and laser Doppler flowmetry...
May 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28429615/regulation-of-vascular-large-conductance-calcium-activated-potassium-channels-by-nrf2-signalling
#2
Yong Li, Xiao-Li Wang, Xiaojing Sun, Qiang Chai, Jingchao Li, Benjamin Thompson, Win-Kuang Shen, Tong Lu, Hon-Chi Lee
BK channels are major ionic determinants of vasodilation. BK channel function is impaired in diabetic vessels due to accelerated proteolysis of its beta-1 (BK-β1) subunits in response to increased oxidative stress. The nuclear factor E2-related factor-2 (Nrf2) signalling pathway has emerged as a master regulator of cellular redox status, and we hypothesized that it plays a central role in regulating BK channel function in diabetic vessels. We found that Nrf2 expression was markedly reduced in db/db diabetic mouse aortas, and this was associated with significant downregulation of BK-β1...
April 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28423914/current-views-on-neuropeptide-y-and-diabetes-related-atherosclerosis
#3
Wei-Wei Sun, Ping Zhu, Yan-Chuan Shi, Chen-Liang Zhang, Xu-Feng Huang, Shi-Yu Liang, Zhi-Yuan Song, Shu Lin
Diabetes-induced atherosclerotic cardiovascular disease is the leading cause of death of diabetic patients. Neuronal regulation plays a critical role in glucose metabolism and cardiovascular function under physiological and pathological conditions, among which, neurotransmitter neuropeptide Y has been shown to be closely involved in these two processes. Elevated central neuropeptide Y level promotes food intake and reduces energy expenditure, thereby increasing adiposity. Neuropeptide Y is co-localized with noradrenaline in central and sympathetic nervous systems...
April 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28403644/the-effect-of-basal-insulin-glargine-on-the-fibrinolytic-system-and-von-willebrand-factor-in-people-with-dysglycaemia-and-high-risk-for-cardiovascular-events-swedish-substudy-of-the-outcome-reduction-with-an-initial-glargine-intervention-trial
#4
Aslak Rautio, Kurt Boman, Hertzel C Gerstein, Jenny Hernestål-Boman, Shun Fu Lee, Mona Olofsson, Linda Garcia Mellbin
INTRODUCTION: Fibrinolytic factors, plasminogen activator inhibitor-1, tissue plasminogen activator, tissue plasminogen activator/plasminogen activator-complex and the haemostatic factor von Willebrand factor are known markers of cardiovascular disease. Their plasma levels are adversely affected in patients with dysglycaemia, and glucose normalization with insulin glargine might improve the levels of these factors. METHODS: Prespecified Swedish substudy of the Outcome Reduction with an Initial Glargine Intervention trial (ClinicalTrials...
April 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28393566/prognostic-implications-of-myocardial-perfusion-imaging-and-coronary-calcium-score-in-a-macedonian-cohort-of-asymptomatic-patients-with-type-2-diabetes
#5
Irena Peovska Mitevska, Natalija Baneva, Elizabeta Srbinovska, Lily Stojanovska, Vasso Apostolopoulos, Marijan Bosevski
AIM: Type 2 diabetes is a risk factor for coronary artery disease; however, a number of studies have shown that patients are asymptomatic for coronary artery disease. The presence of coronary artery disease in asymptomatic patients with type 2 diabetes was evaluated to determine its impact on management decision and prognosis. METHODS: A total of 75 patients underwent single-photon emission computed tomography myocardial perfusion imaging for detection of suspected coronary artery disease...
April 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28393534/the-impact-of-smoking-on-the-development-of-diabetes-and-its-complications
#6
Mariola Śliwińska-Mossoń, Halina Milnerowicz
Diabetes is one of the most common metabolic disorders and emerges secondary to an interaction between genetic, environmental and lifestyle factors. This work provides an overview of the impact of smoking on the development of vascular complications in this condition and also provides an overview of the potential role of smoking in predisposition to diabetes. There are many studies documenting the impact of smoking on health (not focused on patients with diabetes), suggesting that the health exposure in these individuals is at least comparable to that observed in the general population...
April 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28330386/the-effects-of-dual-therapy-intensification-with-insulin-or-dipeptidylpeptidase-4-inhibitor-on-cardiovascular-events-and-all-cause-mortality-in-patients-with-type-2-diabetes-a-retrospective-cohort-study
#7
Mamza Jil, Mehta Rajnikant, Donnelly Richard, Idris Iskandar
PURPOSE: To compare time to a composite endpoint of non-fatal acute myocardial infarction, non-fatal stroke or all-cause mortality in patients with type 2 diabetes mellitus who had their treatment intensified with a dipeptidylpeptidase-4 inhibitor or insulin following dual-therapy (metformin plus sulfonylurea) failure. METHODS: A retrospective cohort study was conducted on 5238 patients newly treated with either a dipeptidylpeptidase-4 inhibitor or insulin following dual-therapy failure (2007-2014)...
March 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28330385/health-effectiveness-of-community-health-workers-as-a-diabetes-self-management-intervention
#8
Judith Aponte, Tranice D Jackson, Katarzyna Wyka, Cyril Ikechi
OBJECTIVE: To evaluate the health effectiveness of community health workers among three groups (intervention, attentional control and control groups) of Hispanic adults with uncontrolled (HbA1c >8%) type 2 diabetes mellitus. METHODS: This was a randomized clinical trial involving 180 English- and Spanish-speaking Hispanic individuals with uncontrolled type 2 diabetes mellitus, 40-74 years of age, who received diabetes care at an outpatient, public, urban hospital...
March 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28322071/an-additional-bolus-of-rapid-acting-insulin-to-normalise-postprandial-cardiovascular-risk-factors-following-a-high-carbohydrate-high-fat-meal-in-patients-with-type-1-diabetes-a-randomised-controlled-trial
#9
Matthew D Campbell, Mark Walker, Ramzi A Ajjan, Karen M Birch, Javier T Gonzalez, Daniel J West
AIM: To evaluate an additional rapid-acting insulin bolus on postprandial lipaemia, inflammation and pro-coagulation following high-carbohydrate high-fat feeding in people with type 1 diabetes. METHODS: A total of 10 males with type 1 diabetes [HbA1c 52.5 ± 5.9 mmol/mol (7.0% ± 0.5%)] underwent three conditions: (1) a low-fat (LF) meal with normal bolus insulin, (2), a high-fat (HF) meal with normal bolus insulin and (3) a high-fat meal with normal bolus insulin with an additional 30% insulin bolus administered 3-h post-meal (HFA)...
March 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28301953/glucose-variability-aggravates-cardiac-fibrosis-by-altering-akt-signalling-path
#10
Changjiang Ying, Ting Liu, Hongwei Ling, Mingyue Cheng, Xiaoyan Zhou, Shanshan Wang, Yizhen Mao, Lei Chen, Runze Zhang, Wei Li
OBJECTIVE: To study the effect of blood glucose variability on cardiac fibrosis and its mechanism in a model of diabetic cardiomyopathy. METHODS: A total of 45 Sprague Dawley rats were randomly divided into three groups: control, control diabetes mellitus and fluctuated blood glucose groups. Fluctuated blood glucose was induced by daily subcutaneous insulin and intraperitoneal glucose injections at different time points. Blood lipids and glycosylated haemoglobin A1c were assessed...
March 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28467203/gaps-and-barriers-in-the-control-of-blood-glucose-in-people-with-type-2-diabetes
#11
Lawrence Blonde, Pablo Aschner, Clifford Bailey, Linong Ji, Lawrence A Leiter, Stephan Matthaei
BACKGROUND: Glycaemic control is suboptimal in a large proportion of people with type 2 diabetes who are consequently at an increased and avoidable risk of potentially severe complications. We sought to explore attitudes and practices among healthcare professionals that may contribute to suboptimal glycaemic control through a review of recent relevant publications in the scientific literature. METHODS: An electronic search of the PubMed database was performed to identify relevant publications from January 2011 to July 2015...
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28467202/a-rationally-designed-peptide-ia-2-p2-against-type-1-diabetes-in-streptozotocin-induced-diabetic-mice
#12
Lili Shen, Shiping Lu, Dongcheng Huang, Guoliang Li, Kunfeng Liu, Rongyue Cao, Li Zong, Liang Jin, Jie Wu
Recent studies have investigated the potential of type 1 diabetes mellitus-related autoantigens, such as heat shock protein 60, to induce immunological tolerance or to suppress the immune response. A functional 24-residue peptide derived from heat shock protein 60 (P277) has shown anti-type 1 diabetes mellitus potential in experimental animals and in clinical studies, but it also carries a potential atherogenic effect. In this study, we have modified P277 to retain an anti-type 1 diabetes mellitus effect and minimize the atherogenic potential by replacing the P277 B epitope with another diabetes-associated autoantigen, insulinoma antigen-2 (IA-2), to create the fusion peptide IA-2-P2...
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28467201/decreased-systolic-blood-pressure-is-associated-with-increased-risk-of-all-cause-mortality-in-patients-with-type-2-diabetes-and-renal-impairment-a-nationwide-longitudinal-observational-study-of-27-732-patients-based-on-the-swedish-national-diabetes-register
#13
Maria K Svensson, Henri Afghahi, Stefan Franzen, Staffan Björk, Soffia Gudbjörnsdottir, Ann-Marie Svensson, Björn Eliasson
BACKGROUND: Previous studies have shown a U-shaped relationship between systolic blood pressure and risk of all-cause of mortality in patients with type 2 diabetes and renal impairment. AIMS: To evaluate the associations between time-updated systolic blood pressure and time-updated change in systolic blood pressure during the follow-up period and risk of all-cause mortality in patients with type 2 diabetes and renal impairment. PATIENTS AND METHODS: A total of 27,732 patients with type 2 diabetes and renal impairment in the Swedish National Diabetes Register were followed for 4...
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28467200/skin-microvascular-function-in-patients-with-type-1-diabetes-an-observational-study-from-the-onset-of-diabetes
#14
Pia Santesson, Per-Eric Lins, Majid Kalani, Ulf Adamson, Isak Lelic, Gunvor von Wendt, Bengt Fagrell, Gun Jörneskog
BACKGROUND: The development of disturbances in skin microcirculation in type 1 diabetes is not well characterised. We assessed skin microcirculation longitudinally from the onset of diabetes up to 29 years of duration to investigate when such disturbances start. MATERIAL AND METHODS: Seventeen adult patients with type 1 diabetes participated. Skin microvascular function in digit IV of the left hand was investigated by laser Doppler fluxmetry (LDF, arbitrary units [AU])...
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28467199/sodium-glucose-co-transporter-type-2-inhibitors-reduce-evening-home-blood-pressure-in-type-2-diabetes-with-nephropathy
#15
Tsuneo Takenaka, Miyako Kishimoto, Mari Ohta, Osamu Tomonaga, Hiromichi Suzuki
BACKGROUND: The effects of sodium-glucose co-transporter type 2 inhibitors on home blood pressure were examined in type 2 diabetes with nephropathy. METHODS: The patients with diabetic nephropathy were screened from medical records in our hospitals. Among them, 52 patients who measured home blood pressure and started to take sodium-glucose co-transporter type 2 inhibitors were selected. Clinical parameters including estimated glomerular filtration rate, albuminuria and home blood pressure for 6 months were analysed...
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28467198/chronic-nahs-treatment-decreases-oxidative-stress-and-improves-endothelial-function-in-diabetic-mice
#16
Hooi H Ng, Gunes S Yildiz, Jacqueline M Ku, Alyson A Miller, Owen L Woodman, Joanne L Hart
Hydrogen sulphide (H2S) is endogenously produced in vascular tissue and has anti-oxidant and vasoprotective properties. This study investigates whether chronic treatment using the fast H2S donor NaHS could elicit a vasoprotective effect in diabetes. Diabetes was induced in male C57BL6/J mice with streptozotocin (60 mg/kg daily, ip for 2 weeks) and confirmed by elevated blood glucose and glycated haemoglobin levels. Diabetic mice were then treated with NaHS (100 µmol/kg/day) for 4 weeks, and aortae collected for functional and biochemical analyses...
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28467197/difference-in-bilateral-digital-volume-pulse-as-a-novel-non-invasive-approach-to-assessing-arteriosclerosis-in-aged-and-diabetic-subjects-a-preliminary-study
#17
Hsien-Tsai Wu, Kuan-Wei Lee, Wen-Yao Pan, An-Bang Liu, Cheuk-Kwan Sun
OBJECTIVE: This study aimed at validating photoplethysmography for assessing bilateral blood pressure differences through investigating the correlations of digital volume pulse with arteriosclerosis risk. METHODS: Totally, 111 subjects (70 healthy and 41 diabetic) were recruited. Demographic, blood pressure and anthropometric data were recorded. Blood was collected for determining serum cholesterol, total triglyceride, total cholesterol, high-/low-density lipoprotein cholesterol, fasting blood sugar and glycated haemoglobin concentrations...
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28467196/pcsk9-inhibitors-a-new-age-in-lipid-management
#18
Peter J Grant
No abstract text is available yet for this article.
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28301218/retinal-pathology-is-associated-with-increased-blood-retina-barrier-permeability-in-a-diabetic-and-hypercholesterolaemic-pig-model-beneficial-effects-of-the-lppla2-inhibitor-darapladib
#19
Nimish K Acharya, Xin Qi, Eric L Goldwaser, George A Godsey, Hao Wu, Mary C Kosciuk, Theresa A Freeman, Colin H Macphee, Robert L Wilensky, Venkat Venkataraman, Robert G Nagele
Using a porcine model of diabetes mellitus and hypercholesterolaemia, we previously showed that diabetes mellitus and hypercholesterolaemia is associated with a chronic increase in blood-brain barrier permeability in the cerebral cortex, leading to selective binding of immunoglobulin G and deposition of amyloid-beta1-42 peptide in pyramidal neurons. Treatment with Darapladib (GlaxoSmithKline, SB480848), an inhibitor of lipoprotein-associated phospholipase-A2, alleviated these effects. Here, investigation of the effects of chronic diabetes mellitus and hypercholesterolaemia on the pig retina revealed a corresponding increased permeability of the blood-retina barrier coupled with a leak of plasma components into the retina, alterations in retinal architecture, selective IgG binding to neurons in the ganglion cell layer, thinning of retinal layers due to cell loss and increased glial fibrillary acidic protein expression in Müller cells, all of which were curtailed by treatment with Darapladib...
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28183205/inhibition-of-rho-kinase-protects-from-ischaemia-reperfusion-injury-via-regulation-of-arginase-activity-and-nitric-oxide-synthase-in-type-1-diabetes
#20
Yahor Tratsiakovich, Attila Kiss, Adrian T Gonon, Jiangning Yang, Per-Ove Sjöquist, John Pernow
AIM: RhoA/Rho-associated kinase and arginase are implicated in vascular complications in diabetes. This study investigated whether RhoA/Rho-associated kinase and arginase inhibition protect from myocardial ischaemia-reperfusion injury in type 1 diabetes and the mechanisms behind these effects. METHODS: Rats with streptozotocin-induced type 1 diabetes and non-diabetic rats were subjected to 30 min myocardial ischaemia and 2 h reperfusion after being randomized to treatment with (1) saline, (2) RhoA/Rho-associated kinase inhibitor hydroxyfasudil, (3) nitric oxide synthase inhibitor N(G)-monomethyl-l-arginine monoacetate followed by hydroxyfasudil, (4) arginase inhibitor N-omega-hydroxy-nor-l-arginine, (5) N(G)-monomethyl-l-arginine monoacetate followed by N-omega-hydroxy-nor-l-arginine or (6) N(G)-monomethyl-l-arginine monoacetate given intravenous before ischaemia...
May 2017: Diabetes & Vascular Disease Research
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