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Acta Biomaterialia

Shine Tone, Masahiro Hasegawa, Leonardo Puppulin, Giuseppe Pezzotti, Akihiro Sudo
No abstract text is available yet for this article.
November 10, 2018: Acta Biomaterialia
Weifeng Lin, Reut Mashiah, Jasmine Seror, Assaf Kadar, Oleg Dolkart, Tamir Pritsch, Ronit Goldberg, Jacob Klein
Hyaluronan (HA)-lipid layers on model (mica) surfaces massively reduce friction as the surfaces slide past each other, and have been proposed, together with lubricin, as the boundary layers accounting for the extreme lubrication of articular cartilage. The ability of such HA-lipid complexes to lubricate sliding biological tissues has not however been demonstrated. Here we show that HA-lipid layers on the surface of an intrasynovial tendon can strongly reduce the friction as the tendon slides within its sheath...
November 10, 2018: Acta Biomaterialia
Benjamin M Richardson, Daniel G Wilcox, Mark A Randolph, Kristi S Anseth
Cartilage tissue engineering strategies often rely on hydrogels with fixed covalent crosslinks for chondrocyte encapsulation; yet the resulting material properties are largely elastic and can impede matrix deposition. To address this limitation, hydrazone crosslinked poly(ethylene glycol) hydrogels were formulated to achieve tunable viscoelastic properties and to study how chondrocyte proliferation and matrix deposition vary with the time-dependent material properties of covalent adaptable networks. Hydrazone equilibrium differences were leveraged to produce average stress relaxation times from hours (4...
November 9, 2018: Acta Biomaterialia
Marta Miola, Yousef Pakzad, Sara Banijamali, Saeid Kargozar, Chiara Vitale-Brovarone, Abolfazl Yazdanpanah, Oana Bretcanu, Arash Ramedani, Enrica Vernè, Masoud Mozafari
After years of research on the ability of glass-ceramics in bone regeneration, this family of biomaterials has shown revolutionary potentials in a couple of emerging applications such as cancer treatment. Although glass-ceramics have not yet reached their actual potential in cancer therapy, the relevant research activity is significantly growing in this field. It has been projected that this idea and the advent of magnetic bioactive glass-ceramics and mesoporous bioactive glasses could result in major future developments in the field of cancer...
November 8, 2018: Acta Biomaterialia
Matthew R Arkenberg, Dustin M Moore, Chien-Chi Lin
Cell-laden hydrogels whose crosslinking density can be dynamically and reversibly tuned are highly sought-after for studying pathophysiological cellular fate processes, including embryogenesis, fibrosis, and tumorigenesis. Special efforts have focused on controlling network crosslinking in poly(ethylene glycol) (PEG) based hydrogels to evaluate the impact of matrix mechanics on cell proliferation, morphogenesis, and differentiation. In this study, we sought to design dynamic PEG-peptide hydrogels that permit cyclic/reversible stiffening and softening...
November 8, 2018: Acta Biomaterialia
Juan L Paris, Paz de la Torre, M Victoria Cabañas, Miguel Manzano, Ana I Flores, María Vallet-Regí
A Trojan-horse strategy for cancer therapy employing tumor-tropic mesenchymal stem cells transfected with a non-viral nanovector is here presented. In this sense, ultrasound-responsive mesoporous silica nanoparticles were coated with a polycation (using two different molecular weights), providing them with gene transfection capabilities that were evaluated using two different plasmids. First, the expression of Green Fluorescent Protein was analyzed in Decidua-derived Mesenchymal Stem Cells after incubation with the silica nanoparticles...
November 7, 2018: Acta Biomaterialia
Rongchen Xu, Fan Yu, Li Huang, Wei Zhou, Yan Wang, Fu Wang, Xiang Sun, Gang Chang, Ming Fang, Ling Zhang, Fang Li, Franklin Tay, Lina Niu, Jihua Chen
Commercially available dental adhesives fail to chemically unite the demineralized collagen matrix with resinous materials within the resin-dentin interface. Sub-micron separations between the collagen fibrils and polymerized resin provide the backdrop for bond deterioration. Here, novel isocyanate-terminated urethane methacrylate precursors (UMP) were synthesized with the capacity to bond chemically to dentin collagen via covalent and hydrogen bonds. Collagen grafted with UMP also copolymerized with other methacrylate resin monomers, thereby producing a monoblock of chemically-linked biocomposite...
November 7, 2018: Acta Biomaterialia
Jia Wen, Yinghua Lv, Yongqian Xu, Pengfei Zhang, Hongjuan Li, Xiaoxu Chen, Xueliang Li, Lingkai Zhang, Fengyu Liu, Wenxian Zeng, Shiguo Sun
A novel biodegradable versatile nanocarrier (FA-CM) was fabricated based on the self-assembly of delaminated CoAl-layered double hydroxides (LDHs) and manganese dioxide (MnO2 ) for optional combination cancer therapy. Biodegradation, versatility, targeting, bioimaging, in vitro cytotoxicity and in vivo antitumor efficacy were evaluated. The results showed that FA-CM could not only be effectively degraded into Co2+ , Al3+ and Mn2+ to overcome the long-term toxic side effects, but also successfully load any positive-charged, negative-charged, hydrophilic, and hydrophobic drug, meeting the critical requirement of versatile nanocarrier...
November 7, 2018: Acta Biomaterialia
Chun Liu, Benjamin Chiang, Daniela Lewin Mejia, Kathryn E Luker, Gary D Luker, Andre Lee
Architecture and microstructure of type I collagen fibers constitute central regulators of tumor invasion with aligned fibers providing a route for migration of stromal and cancer cells. Several different aspects of fibrillar collagen, such as stiffness, density, thickness, and pore size, may regulate migration of cancer cells, but determining effects of any one parameter requires clear decoupling of physical properties of collagen networks. The objective of this work is to develop and apply an in vitro three-dimensional (3D) tumor-extra cellular matrix (ECM) model with tunable physical parameters to define how stromal fibroblasts modulate collagen microstructure to control migration of breast cancer cells...
November 7, 2018: Acta Biomaterialia
Kaiyang Yin, Prajan Divakar, Ulrike G K Wegst
As a new strategy for improved urinary drainage in parallel to the potential for additional functions such as drug release and self-removal, highly porous chitosan stents are manufactured by radial, bi-directional freeze-casting. Inserting the porous stent in a silicone tube to emulate its placement in the ureter shows that it is shape conforming and remains safely positioned in place, also during flow tests, including those performed in a peristaltic pump. Cyclic compression tests on fully-hydrated porous stents reveal high stent resilience and close to full elastic recovery upon unloading...
November 7, 2018: Acta Biomaterialia
C Tsui, K Koss, M A Churchward, K G Todd
Microglia are multi-functional cells that play a vital role in establishing and maintaining the function of the nervous system and determining the fate of neurons following injury or neuropathology. The roles of microglia are diverse and essential to the capacity of the nervous system to recover from injury, however sustained inflammation can limit recovery and drive chronic disease processes such as neurodegenerative disorders. When assessing implantable therapeutic devices in the central nervous system, an improved lifetime of the implant is considered achievable through the attenuation of microglial inflammation...
November 7, 2018: Acta Biomaterialia
Steffen Braun, Robert Sonntag, Stefan Schroeder, Ulrike Mueller, Sebastian Jaeger, Jan Philippe Kretzer
INTRODUCTION: Besides head-insert articulation in hip joint replacements, micro-motions between the backside of assembled polyethylene acetabular liners and the metal cup may cause additional wear. Pelvic osteolysis frequently occurs in the region of screw holes, and cup loosening hints to clinically relevant amounts of polyethylene backside wear. It has yet to be confirmed whether backside wear particles differ in size and morphology compared to articulating wear. Previous methods have been limited to subjective assessment of backside surface damages without consideration of wear debris...
November 5, 2018: Acta Biomaterialia
Laurence E Rustom, Michael J Poellmann, Amy J Wagoner Johnson
With the increasing demand for novel bone repair solutions that overcome the drawbacks of current grafting techniques, the design of artificial bone scaffolds is a central focus in bone regeneration research. Calcium phosphate scaffolds are interesting given their compositional similarity with bone mineral. The majority of studies focus on bone growth in the macropores (> 100 microns) of implanted calcium phosphate scaffolds where bone structures such as osteons and trabeculae can form. However, a growing body of research shows that micropores (< 50 microns) play an important role not only in improving bone growth in the macropores, but also in providing additional space for bone growth...
November 5, 2018: Acta Biomaterialia
Jiajing Tang, Qiantao Wang, Qianwen Yu, Yue Qiu, Ling Mei, Dandan Wan, Xuhui Wang, Man Li, Qin He
The application of tumor targeting ligands to the treatment of cancer holds promise for improving efficacy and reducing toxicity. L T7 (L (HAIYPRH)) peptide, a phage display-selected peptide, exhibited high binding affinity to transferrin receptor (TfR) overexpressed on tumor cells. However, its in vivo tumor targeting efficiency was impaired due to enzymatic degradation in blood circulation. To improve the stability and targeting ability, a retro-inverso analogue of L T7 peptide, named D T7 peptide (D (HRPYIAH)), was designed for targeted therapy of hepatocellular carcinoma...
November 2, 2018: Acta Biomaterialia
Xiao Lu, Ling Han, Ghassan S Kassab
BACKGROUND: There is a significant clinical need for small vascular grafts < 1 mm in diameter. MATERIALS AND METHODS: The structure and composition of swine pulmonary visceral pleura (PVP) were investigated. Two processes, glutaraldehyde (GA) crosslink and decellularization (dc) plus GA crosslink, were used to inhibit the immune response. The thrombosis-resistance of the GA-crosslinked PVP (GA-PVP) was determined with in vitro and in vivo studies. Small vessel grafts with 0...
November 2, 2018: Acta Biomaterialia
Bei Feng, Shoubao Wang, Dongjian Hu, Wei Fu, Jinglei Wu, Haifa Hong, Ibrahim J Domian, Fen Li, Jinfen Liu
Post-cardiac surgical sternal and epicardial adhesions increase the risk and complexity of cardiac re-operative surgeries, which represent a significant challenge for patients with the congenital cardiac disease. Bioresorbable membranes can serve as barriers to prevent postoperative adhesions. Herein, we fabricated a bioresorbable gelatin/polycaprolactone (GT/PCL) composite membrane via electrospinning. The membrane was characterized in terms of morphology, mechanical properties, and biocompatibility. We then evaluated its efficacy as a physical barrier to prevent cardiac operative adhesions in a rabbit model...
October 31, 2018: Acta Biomaterialia
S M Ahmadi, R Kumar, E V Borisov, R Petrov, S Leeflang, Y Li, N Tümer, R Huizenga, C Ayas, A A Zadpoor, V A Popovich
Recently, lattice titanium manufactured by additive manufacturing (AM) techniques has been utilized in various applications, including biomedical. The effects of topological design and processing parameters on the fatigue behaviour of such meta-biomaterials have been studied before. Most studies show that the fatigue life of additively manufactured lattice structures is limited. Post-processing techniques could play a major role in improving the fatigue of these promising biomaterials. This study aims to provide an in-depth investigation into the effects of heat treatments, hot isostatic pressing (HIP), sand blasting, and chemical etching on the microstructure, surface morphology, strength and fatigue resistance of selective laser melted titanium meta-biomaterials...
October 30, 2018: Acta Biomaterialia
Jaganmohan R Jangamreddy, Michel K C Haagdorens, M Mirazul Islam, Philip Lewis, Ayan Samanta, Per Fagerholm, Aneta Liszka, Monika K Ljunggren, Oleksiy Buznyk, Emilio I Alarcon, Nadia Zakaria, Keith M Meek, May Griffith
No abstract text is available yet for this article.
October 29, 2018: Acta Biomaterialia
Pascal Morissette Martin, Aaron Grant, Douglas W Hamilton, Lauren E Flynn
There is a substantial need for new strategies to stimulate cutaneous tissue repair in the treatment of chronic wounds. To address this challenge, our team is developing modular biomaterials termed "bead foams", comprised of porous beads synthesized exclusively of extracellular matrix (ECM) and assembled into a cohesive three-dimensional (3-D) network. In the current study, bead foams were fabricated from human decellularized adipose tissue (DAT) or commercially-sourced bovine tendon collagen (COL) to explore the effects of ECM composition on human wound edge dermal fibroblasts (weDF) sourced from chronic wound tissues...
October 29, 2018: Acta Biomaterialia
Steven Vermeulen, Aliaksei Vasilevich, Dimitrios Tsiapalis, Nadia Roumans, Pascal Vroemen, Nick R M Beijer, Aysegul Dede-Eren, Dimitrios Zeugolis, Jan de Boer
Tenocytes, the main cell type of the tendon, require mechanical stimuli for their proper function. When the tenocyte environment changes due to tissue damage or by transferring tenocytes from their native environment into cell culture, the signals from the tenocyte niche are lost, leading towards a decline of phenotypic markers. It is known that micro-topographies can influence cell fate by the physical cues they provide. To identify the optimal topography-induced biomechanical niche in vitro, we seeded tenocytes on the TopoChip, a micro-topographical screening platform, and measured expression of the tendon transcription factor Scleraxis...
October 27, 2018: Acta Biomaterialia
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