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Acta Biomaterialia

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https://www.readbyqxmd.com/read/28193542/sulfated-hyaluronic-acid-hydrogels-with-retarded-degradation-and-enhanced-growth-factor-retention-promote-hmsc-chondrogenesis-and-articular-cartilage-integrity-with-reduced-hypertrophy
#1
Qian Feng, Sien Lin, Kunyu Zhang, Chaoqun Dong, Tianyi Wu, Heqin Huang, Xiaohui Yan, Li Zhang, Gang Li, Liming Bian
: Recently, hyaluronic acid (HA) hydrogels have been extensively researched for delivering cells and drugs to repair damaged tissues, particularly articular cartilage. However, the in vivo degradation of HA is fast, thus limiting the clinical translation of HA hydrogels. Furthermore, HA cannot bind proteins with high affinity because of the lack of negatively charged sulfate groups. In this study, we conjugated sulfate groups to HA. These sulfated HA exhibit significantly slower degradation by hyaluronidase compared to the wild type HA...
February 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28193541/a-nano-scaled-and-multi-layered-recombinant-fibronectin-cadherin-chimera-composite-selectively-concentrates-osteogenesis-related-cells-and-factors-to-aid-bone-repair
#2
Junchao Xing, Tieniu Mei, Keyu Luo, Zhiqiang Li, Aijun Yang, Zhilin Li, Zhao Xie, Zehua Zhang, Shiwu Dong, Tianyong Hou, Jianzhong Xu, Fei Luo
: Easily accessible and effective bone grafts are in urgent need in clinic. The selective cell retention (SCR) strategy, by which osteogenesis-related cells and factors are enriched from bone marrow into bio-scaffolds, holds great promise. However, the retention efficacy is limited by the relatively low densities of osteogenesis-related cells and factors in marrow; in addition, a lack of satisfactory surface modifiers for scaffolds further exacerbates the dilemma. To address this issue, a multi-layered construct consisting of a recombinant fibronectin/cadherin chimera was established via a layer-by-layer self-assembly technique (LBL-rFN/CDH) and used to modify demineralised bone matrix (DBM) scaffolds...
February 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28193540/unusual-behaviour-induced-by-phase-separation-in-hydrogel-microspheres
#3
C L Heaysman, G J Phillips, A W Lloyd, A L Lewis
: Hydrogel microspheres with the capability to interact with charged species such as various drugs by ion-exchange processes are useful in a variety of biomedical applications. Such systems have been developed to allow active loading of the microsphere with chemotherapeutic agents in the hospital pharmacy for subsequent locoregional therapy of tumours in the liver by drug-eluting bead chemoembolization (DEB-TACE). A variety of microspherical embolisation systems have been described, all based upon hydrogels bearing anionic functionalities to allow interaction with cationically charged drugs...
February 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28189813/strong-tissue-glue-with-tunable-elasticity
#4
Regina Kelmansky, Brian McAlvin, Abraham Nyska, Jenny Dohlman, Homer H Chiang, Michinao Hashimoto, Daniel S Kohane, Boaz Mizrahi
: Many bio-adhesive materials adhere weakly to tissue due to their high water content and weak structural integrity. Others provide desirable adhesive strength but suffer from rigid structure and lack of elasticity after administration. We have developed two water-free, liquid four-armed PEG pre-polymers modified with NHS or with NH2 end groups which upon mixing changed from liquids to an elastic solid. The sealant and adhesive properties increased with the amount of the%v/v PEG4-NHS pre-polymer, and achieved adhesive properties comparable to those of cyanoacrylate glues...
February 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28189812/trimethyl-chitosan-based-conjugates-for-oral-and-intravenous-delivery-of-paclitaxel
#5
Rui He, Chunhua Yin
: Paclitaxel (PTX) conjugated trimethyl chitosan (TMC-PTX) and folic acid (FA) modified TMC-PTX (FA-TMC-PTX) were developed as polymer-drug conjugates for oral and intravenous delivery of PTX. As amphiphilic conjugates, TMC-PTX and FA-TMC-PTX containing approximately 11 wt% PTX could self-assemble into spherical nanoparticles with average sizes of 170 and 187 nm, respectively. The conjugates presented a sustained release of PTX and the release rate was positively correlated with the pH value of medium ranging from 1...
February 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28185910/ultrasoft-microwire-neural-electrodes-improve-chronic-tissue-integration
#6
Zhanhong Jeff Du, Christi L Kolarcik, Takashi D Y Kozai, Silvia D Luebben, Shawn A Sapp, Xin Sally Zheng, James A Nabity, X Tracy Cui
: Chronically implanted neural multi-electrode arrays (MEA) are an essential technology for recording electrical signals from neurons and/or modulating neural activity through stimulation. However, current MEAs, regardless of the type, elicit an inflammatory response that ultimately leads to device failure. Traditionally, rigid materials like tungsten and silicon have been employed to interface with the relatively soft neural tissue. The large stiffness mismatch is thought to exacerbate the inflammatory response...
February 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28185909/customized-biomaterials-to-augment-chondrocyte-gene-therapy
#7
Nizeet I Aguilar, Stephen Trippel, Shuiliang Shi, Lawrence J Bonassar
: A persistent challenge in enhancing gene therapy is the transient availability of the target gene product. This is particularly true in tissue engineering applications. The transient exposure of cells to the product could be insufficient to promote tissue regeneration. Here we report the development of a new material engineered to have a high affinity for a therapeutic gene product. We focus on insulin-like growth factor-I (IGF-I) for its highly anabolic effects on many tissues such as spinal cord, heart, brain and cartilage...
February 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28179161/electrospun-nanofiber-sheets-incorporating-methylcobalamin-promote-nerve-regeneration-and-functional-recovery-in-a-rat-sciatic-nerve-crush-injury-model
#8
Koji Suzuki, Hiroyuki Tanaka, Mitsuhiro Ebara, Koichiro Uto, Hozo Matsuoka, Shunsuke Nishimoto, Kiyoshi Okada, Tsuyoshi Murase, Hideki Yoshikawa
: Peripheral nerve injury is one of common traumas. Although injured peripheral nerves have the capacity to regenerate, axon regeneration proceeds slowly and functional outcomes are often poor. Pharmacological enhancement of regeneration can play an important role in increasing functional recovery. In this study, we developed a novel electrospun nanofiber sheet incorporating methylcobalamin (MeCbl), one of the active forms of vitamin B12 homologues, to deliver it enough locally to the peripheral nerve injury site...
February 4, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28179160/tubular-collagen-scaffolds-with-radial-elasticity-for-hollow-organ-regeneration
#9
Luuk R Versteegden, Kenny A van Kampen, Heinz P Janke, Dorien M Tiemessen, Theo G Hafmans, Edwin A Roozen, Roger M Lomme, Harry van Goor, Egbert Oosterwijk, Wout F Feitz, Toin H van Kuppevelt, Willeke F Daamen
: Tubular collagen scaffolds have been used for the repair of damaged hollow organs in regenerative medicine, but they generally lack the ability to reversibly expand in radial direction, a physiological characteristic seen in many native tubular organs. In this study, tubular collagen scaffolds were prepared that display a shape recovery effect and therefore exhibit radial elasticity. Scaffolds were constructed by compression of fibrillar collagen around a star-shaped mandrel, mimicking folds in a lumen, a typical characteristic of empty tubular hollow organs, such as ureter or urethra...
February 4, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28179159/in-vivo-osteogenic-differentiation-of-stem-cells-inside-compartmentalized-capsules-loaded-with-co-cultured-endothelial-cells
#10
Clara R Correia, Tírcia C Santos, Rogério P Pirraco, Mariana T Cerqueira, Alexandra P Marques, Rui L Reis, João F Mano
: Capsules coated with polyelectrolytes and co-encapsulating adipose stem (ASCs) and endothelial (ECs) cells with surface modified microparticles are developed. Microparticles and cells are freely dispersed in a liquified core, responsible to maximize the diffusion of essential molecules and allowing the geometrical freedom for the autonomous three-dimensional (3D) organization of cells. While the membrane wraps all the instructive cargo elements within a single structure, the microparticles provide a solid 3D substrate for the encapsulated cells...
February 4, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28179158/a-comparative-study-of-simulated-body-fluids-in-the-presence-of-proteins
#11
Weitian Zhao, Jacques Lemaître, Paul Bowen
: Simulated body fluid (SBF) is widely used as part of an in vitro method to evaluate implant materials such as their apatite forming ability (AFA), a typical indication of potential bone-bonding ability in vivo. We report the use of carbonate-buffered SBFs as potential solutions for implant evaluation and the effect of proteins, represented by bovine serum albumin (BSA) in SBFs on the nucleation and growth of hydroxyapatite (HA). These solutions are buffered by the thermodynamic equilibrium with 5% CO2 in an incubator, and result in a deposition of carbonated HA...
February 4, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28179157/the-influence-of-cell-and-nanoparticle-properties-on-heating-and-cell-death-in-a-radiofrequency-field
#12
Yuri Mackeyev, Colette Mark, Natasha Kumar, Rita E Serda
: The use of non-invasive radiofrequency (RF) energy to induce mild thermal and non-thermal effects in cancer tissue is under study as an adjuvant to chemo, radio or immuno therapy. This study examines cell specific sensitivities to RF exposure and the potential of nanoparticles to elevate heating rates or enhance biological effects. Increases in the heating rate of water in an RF field operating at 13.56 MHz (0.004-0.028 °C/s) were positively correlated with concentration of hybrid nanoparticles (1-10 mg/ml) consisting of water soluble malonodiserinolamide [60]fullerene (C60-ser) conjugated to the surface of mesoporous silica nanoparticles (SiO2-C60)...
February 4, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28169170/corrigendum-to-heparinized-collagen-sutures-for-sustained-delivery-of-pdgf-bb-delivery-profile-effects-on-tendon-derived-cells-in-vitro-acta-biomater-41-2016-100-109
#13
Mousa Younesi, Baris Ozgur Donmez, Anowarul Islam, Ozan Akkus
No abstract text is available yet for this article.
February 4, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28167301/non-invasive-tracking-of-injected-bone-marrow-mononuclear-cells-to-injury-and-implanted-biomaterials
#14
Richard P Tan, Bob S L Lee, Alex H P Chan, Sui Ching G Yuen, Juichien Hung, Steven G Wise, Martin K C Ng
: Biomaterial scaffolds enhancing the engraftment of transplanted bone-marrow mononuclear cells (BM-MNC) have enormous potential for tissue regeneration applications. However, development of appropriate materials is challenging given the precise microenvironments required to support BM-MNC engraftment and function. In this study, we have developed a non-invasive, real-time tracking model of injected BM-MNC engraftment to wounds and implanted biomaterial scaffolds. BM-MNCs, encoded with firefly luciferase and enhanced GFP reporter genes, were tail vein injected into subcutaneously wounded mice...
February 3, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28167300/a-poly-l-glutamic-acid-combretastatin-a4-conjugate-for-solid-tumor-therapy-markedly-improved-therapeutic-efficiency-through-its-low-tissue-penetration-in-solid-tumor
#15
Tianzhou Liu, Dawei Zhang, Wantong Song, Zhaohui Tang, Jiaming Zhu, Zhiming Ma, Xudong Wang, Xuesi Chen, Ti Tong
: Combretastatin A4 (CA4) is a leading agent in vascular disrupting strategies for tumor therapy. Although many small-molecule prodrugs of CA4 have been developed to improve its solubility, the overall therapeutic efficiency is moderate. A key reason for this is the reversible effect that CA4 has on tubulin as well as its rapid clearance from plasma and tissues. In this study, we proposed a poly(L-glutamic acid)-CA4 conjugate (PLG-CA4) nanomedicine to fulfill the requirements for fully liberating the potential of CA4 on tumor therapy...
February 3, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28163239/enhanced-elastin-synthesis-and-maturation-in-human-vascular-smooth-muscle-tissue-derived-from-induced-pluripotent-stem-cells
#16
Joon H Eoh, Nian Shen, Jacqueline A Burke, Svenja Hinderer, Zhiyong Xia, Katja Schenke-Layland, Sharon Gerecht
: Obtaining vascular smooth muscle tissue with mature, functional elastic fibers is a key obstacle in tissue-engineered blood vessels. Poor elastin secretion and organization leads to a loss of specialization in contractile smooth muscle cells, resulting in over proliferation and graft failure. In this study, human induced-pluripotent stem cells (hiPSCs) were differentiated into early smooth muscle cells, seeded onto a hybrid poly(ethylene glycol) dimethacrylate/poly (L-lactide) (PEGdma-PLA) scaffold and cultured in a bioreactor while exposed to pulsatile flow, towards maturation into contractile smooth muscle tissue...
February 2, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28163238/extraordinary-high-strength-ti-zr-ta-alloys-through-nanoscaled-dual-cubic-spinodal-reinforcement
#17
Arne Biesiekierski, Dehai Ping, Yuncang Li, Jixing Lin, Khurram S Munir, Yoko Yamabe-Mitarai, Cuie Wen
: While titanium alloys represent the current state-of-the-art for orthopedic biomaterials, concerns still remain over their modulus. Circumventing this via increased porosity requires high elastic admissible strains, yet also limits traditional thermomechanical strengthening techniques. To this end, a novel β-type Ti-Zr-Ta alloy system, comprised of Ti-45Zr-10Ta, Ti-40Zr-14Ta, Ti-35Zr-18Ta and Ti-30Zr-22Ta, was designed and characterized mechanically and microstructurally. As-cast, this system displayed extremely high yield strengths and elastic admissible strains, up to 1...
February 2, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28163237/biophysical-characterization-of-functionalized-titania-nanoparticles-and-their-application-in-dental-adhesives
#18
Jirun Sun, Elijah J Petersen, Stephanie S Watson, Christopher M Sims, Alexander Kassman, Stanislav Frukhtbeyn, Drago Skrtic, Meryem T Ok, Debbie L Jacobs, Vytas Reipa, Qiang Ye, Bryant C Nelson
: It is demonstrated that carboxylic acid-functionalized titanium dioxide (TiO2) NPs produce significantly higher levels of reactive oxygen species (ROS) after visible light irradiation (400 nm to 800 nm, 1600 mW/cm(2)) in comparison to nonfunctionalized TiO2 NPs. The level of ROS produced under these irradiation conditions was not capable of generating oxidatively induced DNA damage in a cell-free system for TiO2 concentrations of 0.5 mg/L or 5 mg/L. In addition, specific incorporation of the acrylic acid-functionalized TiO2 NPs into dental composites allowed us to utilize the generated ROS to enhance photopolymerization (curing and degree of vinyl conversion (DC)) of resin adhesives and create mechanically superior and biocompatible materials for dental applications...
February 2, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28161574/covalent-growth-factor-tethering-to-direct-neural-stem-cell-differentiation-and-self-organization
#19
Trevor R Ham, Mahmoud Farrag, Nic D Leipzig
: Tethered growth factors offer exciting new possibilities for guiding stem cell behavior. However, many of the current methods present substantial drawbacks which can limit their application and confound results. In this work, we developed a new method for the site-specific covalent immobilization of azide-tagged growth factors and investigated its utility in a model system for guiding neural stem cell (NSC) behavior. An engineered interferon-γ (IFN-γ) fusion protein was tagged with an N-terminal azide group, and immobilized to two different dibenzocyclooctyne-functionalized biomimetic polysaccharides (chitosan and hyaluronan)...
February 2, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28161576/molecular-assessment-of-collagen-denaturation-in-decellularized-tissues-using-a-collagen-hybridizing-peptide
#20
Jeongmin Hwang, Boi Hoa San, Neill J Turner, Lisa J White, Denver M Faulk, Stephen F Badylak, Yang Li, S Michael Yu
: Decellularized extracellular matrix (ECM) derived from tissues and organs are emerging as important scaffold materials for regenerative medicine. Many believe that preservation of the native ECM structure during decellularization is highly desirable. However, because effective techniques to assess the structural damage in ECM are lacking, the disruptive effects of a decellularization method and the impact of the associated structural damage upon the scaffold's regenerative capacity are often debated...
February 1, 2017: Acta Biomaterialia
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