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Acta Biomaterialia

Zhaoxin Gu, Xiuxiu Wang, Ru Cheng, Liang Cheng, Zhiyuan Zhong
Bortezomib (BTZ) provides one of the best treatments for multiple myeloma (MM). The efficacy of BTZ is, nevertheless, restricted by its fast clearance, low selectivity, and dose limiting toxicities. Here, we report on targeted BTZ therapy of MM in vivo by hyaluronic acid-shelled and core-disulfide-crosslinked biodegradable micelles (HA-CCMs) encapsulating lipophilized BTZ, bortezomib-pinanediol (BP). HA-CCMs loaded with 7.3 BTZ equiv. wt.% exhibited a small size of 78 nm, good stability in 10% FBS, and glutathione-triggered drug release...
September 18, 2018: Acta Biomaterialia
Yuan Guo, Xing-Yue Wang, Yu-Li Chen, Feng-Qiu Liu, Mi-Xiao Tan, Meng Ao, Jin-Hong Yu, Hai-Tao Ran, Zhao-Xia Wang
Breast cancer is a severe threat to the health and lives of women due to its difficult early diagnosis and the unsatisfactory therapeutic efficacy of breast cancer treatments. The development of theranostic strategies to combat breast cancer with high accuracy and effectiveness is therefore urgently needed. In this study, we describe a near-infrared (NIR) light-controllable, targeted and biocompatible drug delivery nanoplatform (PFH-PTX@PLGA/SPIO-Her) for photoacoustic (PA)/ultrasound (US) bimodal imaging-guided photothermal (PTT) /chemo synergistic cancer therapy of breast cancer...
September 18, 2018: Acta Biomaterialia
Julia Liu, Debashish Das, Fan Yang, Andrea G Schwartz, Guy M Genin, Stavros Thomopoulos, Ioannis Chasiotis
As the fundamental structural protein in mammals, collagen transmits cyclic forces that are necessary for the mechanical function of tissues, such as bone and tendon. Although the tissue-level mechanical behavior of collagenous tissues is well understood, the response of collagen at the nanometer length scales to cyclical loading remains elusive. To address this major gap, we cyclically stretched individual reconstituted collagen fibrils, with average diameter of 141±53 nm, to small and large strains in the partially hydrated conditions of 60% RH...
September 18, 2018: Acta Biomaterialia
Min Sang Lee, Nak Won Kim, Jung Eun Lee, Myung Goo Kim, Yue Yin, Sun Young Kim, Bo Sung Ko, Aeseon Kim, Jong Han Lee, Su Yeon Lim, Dong Woo Lim, Sun Hwa Kim, Ji Won Park, Yong Taik Lim, Ji Hoon Jeong
Direct delivery of proteins into cells has been considered an effective approach for treating the protein-related diseases. However, clinical use of proteins has still been limited due to their instability in the blood and poor membrane permeability. To achieve an efficient cellular delivery of the protein to target cells via a systemic administration, a multifunctional carrier system having desirable stability both in the blood stream and the cells, specific cell-targeting property and endosomal escape functions may be required...
September 18, 2018: Acta Biomaterialia
V Sokolova, K Loza, T Knuschke, J Heinen-Weiler, H Jastrow, M Hasenberg, J Buer, A M Westendorf, M Gunzer, M Epple
Nanoparticles can act as transporters for synthetic molecules and biomolecules into cells, also in immunology. Antigen-presenting cells like dendritic cells are important targets for immunotherapy in nanomedicine. Therefore, we have used primary murine bone marrow-derived phagocytosing cells (bmPCs), i.e. dendritic cells and macrophages, to study their interaction with spherical barium sulphate particles of different size (40 nm, 420 nm, and 1 µm) and to follow their uptake pathway. Barium sulphate is chemically and biologically inert (no dissolution, no catalytic effects), i...
September 18, 2018: Acta Biomaterialia
Matthew R Aronson, Andrew W Simonson, Lindsey M Orchard, Manuel Llinás, Scott H Medina
Anticancer peptides (ACPs) are cationic amphiphiles that preferentially kill cancer cells through folding-dependent membrane disruption. Although ACPs represent attractive therapeutic candidates, particularly against drug-resistant cancers, their successful translation into clinical practice has gone unrealized due to their poor bioavailability, serum instability and, most importantly, severe hemolytic toxicity. Here, we exploit the membrane-specific interactions of ACPs to prepare a new class of peptide-lipid particle, we term a lipopeptisome (LP)...
September 18, 2018: Acta Biomaterialia
C Mattu, G Brachi, L Menichetti, A Flori, P Armanetti, E Ranzato, S Martinotti, S Nizzero, M Ferrari, G Ciardelli
Cancer therapy often relies on the combined action of different molecules to overcome drug resistance and enhance patient outcome. Combined strategies relying on molecules with different pharmacokinetics often fail due to the lack of concomitant tumor accumulation and, thus, in the loss of synergistic effect. Due to their ability to enhance treatment efficiency, improve drug pharmacokinetics, and reduce adverse effects, polymer nanoparticles (PNPs) have been widely investigated as co-delivery vehicles for cancer therapies...
September 17, 2018: Acta Biomaterialia
Harmanvir Ghuman, Carrinton Mauney, Julia Donnelly, Andre R Massensini, Stephen F Badylak, Michel Modo
The brain is considered to have a limited capacity to repair damaged tissue and no regenerative capacity following injury. Tissue lost after a stroke is therefore not spontaneously replaced. Extracellular matrix (ECM)-based hydrogels implanted into the stroke cavity can attract endogenous cells. These hydrogels can be formulated at different protein concentrations that govern their rheological and inductive properties. We evaluated histologically 0, 3, 4 and 8 mg/mL of porcine-derived urinary bladder matrix (UBM)-ECM hydrogel concentrations implanted in a 14-day old stroke cavity...
September 16, 2018: Acta Biomaterialia
Baolin Huang, Yue Lou, Tong Li, Zuo Lin, Suli Sun, Yuan Yuan, Changsheng Liu, Yuantong Gu
Interactions between bone morphogenetic protein-2 (BMP-2) and biomaterial surfaces are of great significance in the fields of regenerative medicine and bone tissue engineering. In this work, the adsorption and desorption behaviors of BMP-2 on a series of nano-textured hydroxyapatite (HAP) surfaces were systematically investigated by combined molecular dynamic (MD) simulations and steered molecular dynamic (SMD) simulations. The textured HAP surfaces exhibited nanostructured topographies and played a critical role in the mediation of dynamic behaviors of BMP-2...
September 14, 2018: Acta Biomaterialia
Linxiao Wu, Jatinder Virdee, Elizabeth Maughan, Arnold Darbyshire, Gavin Jell, Marilena Loizidou, Mark Emberton, Peter Butler, Ashley Howkins, Alan Reynolds, Ian W Boyd, Martin Birchall, Wenhui Song
Cell and tissue stiffness is an important biomechanical signalling parameter for dynamic biological processes; responsive polymeric materials conferring responsive functionality are therefore appealing for in vivo implants. We have developed thermoresponsive poly(urea-urethane) nanohybrid scaffolds with 'stiffness memory' through a versatile 3D printing-guided thermally induced phase separation (3D-TIPS) technique. 3D-TIPS, a combination of 3D printing with phase separation, allows uniform phase-separation and phase transition of the polymer solution at a large interface of network within the printed sacrificial preform, leading to the creation of full-scale scaffolds with bespoke anatomical complex geometry...
September 14, 2018: Acta Biomaterialia
Chunyang Zhou, Hongmei Geng, Chunlei Guo
Despite great potential and extensive interest in developing biomolecule-based computing, the development of even basic molecular logic gates is still in its infancy. Digital comparator (DC) is the basic unit in traditional electronic computers, but it is difficult to construct a system for achieving large-scale integration. Here, we construct, for the first time, a novel logic computing system of DCs that can compare whether two or more numbers are equal. Our approach is by taking advantage of facile preparation and unique properties of graphene oxide and DNA...
September 14, 2018: Acta Biomaterialia
Huaqin Zuo, Junxian Tao, Hua Shi, Jian He, Zhengyang Zhou, Chao Zhang
W18 O49 -mediated photodynamic therapy (PDT) and photothermal therapy (PTT) are limited by the easily oxidized property and tumor hypoxia. Here, we report the development of platelet membranes as nanocarriers to co-load W18 O49 nanoparticles (NPs) and metformin (PM-W18 O49 -Met NPs). Platelet membranes can protect W18 O49 from oxidation and immune evasion, and increase the accumulation of W18 O49 in tumor sites via the passive EPR effect and active adhesion between platelets and cancer cells. The introduction of metformin (Met), a typical anti-diabetic drug, can alleviate the tumor hypoxia through reducing oxygen consumption...
September 14, 2018: Acta Biomaterialia
Yousra Saeed Malik, Muhammad Abid Sheikh, Zhenkai Xing, Zhaopei Guo, Xiaojuan Zhu, Huayu Tian, Xuesi Chen
Glioblastoma remains the most resistant malignant brain tumor owing to the lack of an efficient delivery system for therapeutic genes or drugs, especially in outgrowing tumor islands. Cell-based delivery systems such as mesenchymal stem cells (MSCs) are a potential candidate in this regard. Conventionally, MSCs have been genetically modified for cancer therapy by using viral vectors that can illicit oncogenicity and limit their use in clinical trials. In this study, we have used nonviral agents such as the polylysine-modified polyethylenimine (PEI-PLL) copolymer to generate genetically engineered MSCs with suicidal genes, namely, HSV-TK and TRAIL...
September 14, 2018: Acta Biomaterialia
T Ristori, C V C Bouten, F P T Baaijens, S Loerakker
The hemodynamic functionality of heart valves strongly depends on the distribution of collagen fibers, which are their main load-bearing constituents. It is known that collagen networks remodel in response to mechanical stimuli. Yet, the complex interplay between external load and collagen remodeling is poorly understood. In this study, we adopted a computational approach to simulate collagen remodeling occurring in native fetal and pediatric heart valves. The computational model accounted for several biological phenomena: cellular (re)orientation in response to both mechanical stimuli and topographical cues provided by collagen fibers; collagen deposition and traction forces along the main cellular direction; collagen degradation decreasing with stretch; and cell-mediated collagen prestretch...
September 14, 2018: Acta Biomaterialia
Rui Chen, Yuanman Yu, Wenjing Zhang, Yuanzhong Pan, Jing Wang, Yin Xiao, Changsheng Liu
Bone morphogenetic protein-2 (BMP-2) involved therapy is of great potential for bone regeneration. However, its clinical application is restricted due to the undesirable bioactivity and relevant complications in vivo. Immobilization of recombinant BMP-2 (rhBMP-2) is an efficient strategy to mimic natural microenvironment and retain its bioactivity. Herein, we present evidences indicating that osteoinductive capacity of rhBMP-2 can be regulated via variant immobilizing approaches. Three representative superficial immobilizing models were employed to fabricate rhBMP-2-immobilized surfaces including physical adsorption (Au/rhBMP-2), covalent grafting (rhBMP-2-SAM-Au) and heparin binding (Hep-SAM-Au/rhBMP-2) (SAM: self-assembled monolayer)...
September 12, 2018: Acta Biomaterialia
Yong Y Peng, Thomas Nebl, Veronica Glattauer, John A M Ramshaw
Bacterial collagen-like proteins differ from vertebrate collagens in that they do not contain hydroxyproline, which is seen as a characteristic of the vertebrate collagens, and which provides a significant contribution to the stability of the collagen triple-helix at body temperature. Despite this difference, the bacterial collagens are stable at around body temperature through inclusion of other stabilising sequence elements. Another difference is the lack of aggregation, and certain vertebrate collagen binding domains that can be introduced into the bacterial sequence lack full function when hydroxyproline is absent...
September 12, 2018: Acta Biomaterialia
Britani N Blackstone, Jennifer M Hahn, Kevin L McFarland, Danielle M DeBruler, Dorothy M Supp, Heather M Powell
Engineered skin (ES) offers many advantages over split-thickness skin autografts for the treatment of burn wounds. However, ES, both in vitro and after grafting, is often significantly weaker, less elastic and more compliant than normal human skin. Biomechanical properties of ES can be tuned in vitro using electrospun co-axial (CoA) scaffolds. To explore the potential for coaxial scaffold-based ES use in vivo, two CoA scaffolds were fabricated with bioactive gelatin shells and biodegradable synthetic cores of polylactic acid (PLA) and polycaprolactone (PCL), and compared with gelatin monofilament scaffolds...
September 12, 2018: Acta Biomaterialia
Jiangwei Chen, Yingfei Zhan, Yabin Wang, Dong Han, Bo Tao, Zhenli Luo, Sai Ma, Qun Wang, Xiang Li, Fan Li, Congye Li, Hongbing Deng, Feng Cao
Poor functional survival of the engrafted stem cells limits the therapeutic efficacy of stem-cell-based therapy for myocardial infarction (MI). Cardiac patch-based system for cardiac repair has emerged as a potential regenerative strategy for MI. This study aimed to design a cardiac patch to improve the retention of the engrafted stem cells and provide mechanical scaffold for preventing the ventricular remodeling post-MI. The patches were fabricated with electrospinning cellulose nanofibers modified with chitosan/silk fibroin (CS/SF) multilayers via layer-by-layer (LBL) coating technology...
September 12, 2018: Acta Biomaterialia
Rachel M Cahalane, Hilary E Barrett, Julie M O'Brien, Eamon G Kavanagh, Michael A Moloney, Michael T Walsh
Calcification is associated with decreased atherosclerotic plaque stability and increased failures rates for endovascular interventions. Computational efforts have sought to elucidate the relationship between calcification and plaque rupture in addition to predicting tissue response during aggressive revascularisation techniques. However, calcified material properties are currently estimated and may not reflect real tissue conditions. The objective of this study is to correlate calcification mechanical properties with three radiographic density groups obtained from corresponding Computed Tomography (CT) images...
September 12, 2018: Acta Biomaterialia
Oluwatoosin Bunmi A Agbaje, Ira Ben Shir, David B Zax, Asher Schmidt, Dorrit E Jacob
Bivalve shells are inorganic-organic nanocomposites whose material properties outperform their purely inorganic mineral counterparts. Most typically the inorganic phase is a polymorph of CaCO3 , while the organic phase contains biopolymers which have been presumed to be chitin and/or proteins. Identifying the biopolymer phase is therefore a crucial step in improving our understanding of design principles relevant to biominerals. In this work we study seven shells; four are examples of nacroprismatic shells (Alathyria jacksoni, Pinctada maxima, Hyriopsis cumingii and Cucumerunio novaehollandiae), one homogeneous (Arctica islandica), and two are crossed lamellar (Callista kingii, Tridacna gigas)...
September 11, 2018: Acta Biomaterialia
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