journal
MENU ▼
Read by QxMD icon Read
search

Acta Biomaterialia

journal
https://www.readbyqxmd.com/read/28728969/a-nanoporous-titanium-surface-promotes-the-maturation-of-focal-adhesions-and-the-formation-of-filopodia-with-distinctive-nanoscale-protrusions-by-osteogenic-cells
#1
Dainelys Guadarrama Bello, Aurélien Fouillen, Antonella Badia, Antonio Nanci
While topography is a key determinant of the cellular response to biomaterials the mechanisms implicated in the cell-surface interactions are complex and still not fully elucidated. In this context, we have examined the effect of nanoscale topography on the formation of filopodia, focal adhesions, and on gene expression of proteins associated with cell adhesion and sensing. Commercially pure titanium discs were treated for oxidative nanopatterning with a solution of H2SO4/H2O2 50:50 (v/v). Scanning electron microscopy and atomic force microscopy characterizations showed that this facile chemical treatment efficiently creates a unique nanoporous surface with a root-mean-square roughness of 11...
July 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28716610/current-status-and-future-direction-of-biodegradable-metallic-and-polymeric-vascular-scaffolds-for-next-generation-stents
#2
REVIEW
Seung Hyuk Im, Youngmee Jung, Soo Hyun Kim
Because of the increasing incidence of coronary artery disease, the importance of cardiovascular stents has continuously increased as a treatment of this disease. Biodegradable scaffolds fabricated from polymers and metals have emerged as promising materials for vascular stents because of their biodegradability. Although such stent framework materials have shown good clinical efficacy, it is difficult to decide whether polymers or metals are better vascular scaffolds because their properties are different. Therefore, there are still obstacles in the development of biodegradable vascular scaffolds in terms of improving clinical efficacy...
July 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28713017/intracellular-co-delivery-of-sr-ion-and-phenamil-drug-through-mesoporous-bioglass-nanocarriers-synergizes-bmp-signaling-and-tissue-mineralization
#3
Jung-Hwan Lee, Nandin Mandakhbayar, Ahmed El-Fiqi, Haw-Won Kim
Inducing differentiation and maturation of resident multipotent stem cells (MSCs) is an important strategy to regenerate hard tissues in mal-calcification conditions. Here we explore a co-delivery approach of therapeutic molecules comprised of ion and drug through a mesoporous bioglass nanoparticle (MBN) for this purpose. Recently, MBN has offered unique potential as a nanocarrier for hard tissues, in terms of high mesoporosity, bone bioactivity (and possibly degradability), tunable delivery of biomolecules, and ionic modification...
July 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28713016/a-conducive-bioceramic-polymer-composite-biomaterial-for-diabetic-wound-healing
#4
Fang Lv, Jie Wang, Peng Xu, Yiming Han, Hongshi Ma, He Xu, Shijie Chen, Jiang Chang, Qinfei Ke, Mingyao Liu, Zhengfang Yi, Chengtie Wu
Diabetic wound is a common complication of diabetes. Biomaterials offer great promise in inducing tissue regeneration for chronic wound healing. Herein, we reported a conducive Poly (caprolactone) (PCL)/gelatin nanofibrous composite scaffold containing silicate-based bioceramic particles (Nagelschmidtite, NAGEL, Ca7P2Si2O16) for diabetic wound healing. NAGEL bioceramic particles were well distributed in the inner of PCL/gelatin nanofibers via co-electrospinning process and the Si ions maintained a sustained release from the composite scaffolds during the degradation process...
July 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28713015/folate-conjugated-and-ph-responsive-polymeric-micelles-for-target-cell-specific-anticancer-drug-delivery
#5
Jiao Guan, Zun-Qiang Zhou, Mao-Hua Chen, Hui-Yan Li, Da-Nian Tong, Jun Yang, Jing Yao, Zheng-Yun Zhang
In this study, we developed a folate (FA)-conjugated and pH-responsive active targeting micellar system for anti-cancer drug delivery. In this system, FA was attached to the terminal of the hydrophilic segment of poly(lactic acid)-poly(L-lysine) (PLA-PLL), and PLL was modified by a citric acid group. The FA receptor-mediated active targeting and electrostatic interaction between micelles and cell membrane due to a negative-to-positive charge reversal was combined in one micellar anti-cancer drug delivery system to enhance the tumour targeting and cellular internalisation of micelles...
July 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28711686/hydrogel-elasticity-and-microarchitecture-regulate-dental-derived-mesenchymal-stem-cells-host-immune-system-cross-talk
#6
Sahar Ansari, Chider Chen, Mohammad Mahdi Hasani-Sadrabadi, Bo Yu, Homayoun H Zadeh, Benjamin M Wu, Alireza Moshaverinia
The host immune system (T-lymphocytes and their pro-inflammatory cytokines) has been shown to compromise bone regeneration ability of mesenchymal stem cells (MSCs). We have recently shown that hydrogel, used as an encapsulating biomaterial affects the cross-talk among host immune cells and MSCs. However, the role of hydrogel elasticity and porosity in regulation of cross-talk between dental-derived MSCs and immune cells is unclear. In this study, we demonstrate that the modulus of elasticity and porosity of the scaffold influence T-lymphocyte-dental MSC interplay by regulating the penetration of inflammatory T cells and their cytokines...
July 12, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28709984/micrometer-scale-guidance-of-mesenchymal-stem-cells-to-form-structurally-oriented-large-scale-tissue-engineered-cartilage
#7
Chih-Ling Chou, Alexander L Rivera, Valencia Williams, Jean F Welter, Joseph M Mansour, Judith A Drazba, Takao Sakai, Harihara Baskaran
Current clinical methods to treat articular cartilage lesions provide temporary relief of the symptoms but fail to permanently restore the damaged tissue. Tissue engineering, using mesenchymal stem cells (MSCs) combined with scaffolds and bioactive factors, is viewed as a promising method for repairing cartilage injuries. However, current tissue engineered constructs display inferior mechanical properties compared to native articular cartilage, which could be attributed to the lack of structural organization of the extracellular matrix (ECM) of these engineered constructs in comparison to the highly oriented structure of articular cartilage ECM...
July 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28698163/selective-effect-of-hydroxyapatite-nanoparticles-on-osteoporotic-and-healthy-bone-formation-correlates-with-intracellular-calcium-homeostasis-regulation
#8
Rui Zhao, Pengfei Xie, Kun Zhang, Zhurong Tang, Xuening Chen, Xiangdong Zhu, Yujiang Fan, Xiao Yang, Xingdong Zhang
Adequate bone substitutes osseointegration has been difficult to achieve in osteoporosis. Hydroxyapatite of the osteoporotic bone, secreted by pathologic osteoblasts, had a smaller crystal size and lower crystallinity than that of the normal. To date, little is known regarding the interaction of synthetic hydroxyapatite nanoparticles (HANPs) with osteoblasts born in bone rarefaction. The present study investigated the biological effects of HANPs on osteoblastic cells derived from osteoporotic rat bone (OVX-OB), in comparison with the healthy ones (SHM-OB)...
July 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28698026/corrigendum-to-thiol-ene-michael-type-formation-of-gelatin-poly-ethylene-glycol-biomatrices-for-three-dimensional-mesenchymal-stromal-stem-cell-administration-to-cutaneous-wounds-acta-biomater-9-11-2013-8802-8814
#9
Kedi Xu, David Antonio Cantu, Yao Fu, Jaehyup Kim, Xiaoxiang Zheng, Peiman Hematti, W John Kao
No abstract text is available yet for this article.
July 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28694238/functionalized-bioengineered-spider-silk-spheres-improve-nuclease-resistance-and-activity-of-oligonucleotide-therapeutics-providing-a-strategy-for-cancer-treatment
#10
Anna Karolina Kozlowska, Anna Florczak, Maciej Smialek, Ewelina Dondajewska, Andrzej Mackiewicz, Marcin Kortylewski, Hanna Dams-Kozlowska
Cell-selective delivery and sensitivity to serum nucleases remain major hurdles to the clinical application of RNA-based oligonucleotide therapeutics, such as siRNA. Spider silk shows great potential as a biomaterial due to its biocompatibility and biodegradability. Self-assembling properties of silk proteins allow for processing into several different morphologies such as fibers, scaffolds, films, hydrogels, capsules and spheres. Moreover, bioengineering of spider silk protein sequences can functionalize silk by adding peptide moieties with specific features including binding or cell recognition domains...
July 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28694237/phase-transitions-during-compression-and-decompression-of-clots-from-platelet-poor-plasma-platelet-rich-plasma-and-whole-blood
#11
Xiaojun Liang, Irina Chernysh, Prashant K Purohit, John W Weisel
Blood clots are required to stem bleeding and are subject to a variety of stresses, but they can also block blood vessels and cause heart attacks and ischemic strokes. We measured the compressive response of human platelet-poor plasma (PPP) clots, platelet-rich plasma (PRP) clots and whole blood clots and correlated these measurements with confocal and scanning electron microscopy to track changes in clot structure. Stress-strain curves revealed four characteristic regions, for compression-decompression: (1) linear elastic region; (2) upper plateau or softening region; (3) non-linear elastic region or re-stretching of the network; (4) lower plateau in which dissociation of some newly made connections occurs...
July 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28690008/laminin-mimetic-peptide-nanofibers-regenerate-acute-muscle-defect
#12
Cagla Eren Cimenci, Gozde Uzunalli, Ozge Uysal, Fatih Yergoz, Ebru Karaca Umay, Mustafa O Guler, Ayse B Tekinay
Skeletal muscle cells are terminally differentiated and require the activation of muscle progenitor (satellite) cells for their regeneration. There is a clinical need for faster and more efficient treatment methods for acute muscle injuries, and the stimulation of satellite cell proliferation is promising in this context. In this study, we designed and synthesized a laminin-mimetic bioactive peptide (LM/E-PA) system that is capable of accelerating satellite cell activation by emulating the structure and function of laminin, a major protein of the basal membrane of the skeletal muscle...
July 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28694236/fibrin-functionalization-with-synthetic-adhesive-ligands-interacting-with-%C3%AE-6%C3%AE-1-integrin-receptor-enhance-neurite-outgrowth-of-embryonic-stem-cell-derived-neural-stem-progenitors
#13
Joana Silva, Ana R Bento, Daniela Barros, Tiago L Laundos, Susana R Sousa, Pedro Quelhas, Mónica M Sousa, Ana P Pêgo, Isabel F Amaral
To enhance fibrin hydrogel affinity towards pluripotent stem cell-derived neural stem/progenitor cells (NSPCs) and its capacity to support NSPC migration and neurite extension, we explored the tethering of synthetic peptides engaging integrin α6β1, a cell receptor enriched in NSPCs. Six α6β1 integrin ligands were tested for their ability to support integrin α6β1-mediated adhesion of embryonic stem cell-derived NSPCs (ES-NSPs) and sustain ES-NSPC viability, migration, and neuronal differentiation. Due to their better performance, peptides T1, HYD1, and A5G81 were immobilized into fibrin and functionalized gels characterized in terms of peptide binding efficiency, structure and viscoelastic properties...
July 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28690010/tailoring-surface-nanoroughness-of-electrospun-scaffolds-for-skeletal-tissue-engineering
#14
Honglin Chen, Xiaobin Huang, Minmin Zhang, Febriyani Damanik, Matthew B Baker, Anne Leferink, Huipin Yuan, Roman Truckenmüller, Clemens van Blitterswijk, Lorenzo Moroni
Electrospun scaffolds provide a promising approach for tissue engineering as they mimic the physical properties of extracellular matrix. Previous studies have demonstrated that electrospun scaffolds with porous features on the surface of single fibers, enhanced cellular attachment and proliferation. Yet, little is known about the effect of such topographical cues on cellular differentiation. Here, we aimed at investigating the influence of surface roughness of electrospun scaffolds on skeletal differentiation of human mesenchymal stromal cells (hMSCs)...
July 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28690009/amorphous-surface-layer-versus-transient-amorphous-precursor-phase-in-bone-a-case-study-investigated-by-solid-state-nmr-spectroscopy
#15
Stanislas Von Euw, Widad Ajili, Tsou-Hsi-Camille Chan-Chang, Annette Delices, Guillaume Laurent, Florence Babonneau, Nadine Nassif, Thierry Azaïs
The presence of an amorphous surface layer that coats a crystalline core has been proposed for many biominerals, including bone mineral. In parallel, transient amorphous precursor phases have been proposed in various biomineralization processes, including bone biomineralization. Here we propose a methodology to investigate the origin of these amorphous environments taking the bone tissue as a key example. This study relies on the investigation of a bone tissue sample and its comparison with synthetic calcium phosphate samples, including a stoichiometric apatite, an amorphous calcium phosphate sample, and two different biomimetic apatites...
July 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28690007/bioreactor-induced-mesenchymal-progenitor-cell-differentiation-and-elastic-fiber-assembly-in-engineered-vascular-tissues
#16
Shigang Lin, Kibret Mequanint
In vitro maturation of engineered vascular tissues (EVT) requires the appropriate incorporation of smooth muscle cells (SMC) and extracellular matrix (ECM) components similar to native arteries. To this end, the aim of the current study was to fabricate 4 mm inner diameter vascular tissues using mesenchymal progenitor cells seeded into tubular scaffolds. A dual-pump bioreactor operating either in perfusion or pulsatile perfusion mode was used to generate physiological-like stimuli to promote progenitor cell differentiation, extracellular elastin production, and tissue maturation...
July 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28688988/bactericidal-activity-of-self-assembled-palmitic-and-stearic-fatty-acid-crystals-on-highly-ordered-pyrolytic-graphite
#17
Elena P Ivanova, Song Ha Nguyen, Yachong Guo, Vladimir A Baulin, Hayden K Webb, Vi Khanh Truong, Jason V Wandiyanto, Christopher J Garvey, Peter J Mahon, David E Mainwaring, Russell J Crawford
The wings of insects such as cicadas and dragonflies have been found to exhibit nanostructure arrays that are assembled from fatty acids, and that physically interact with and significantly disrupt bacterial cell membranes. Such mechanobactericidal surfaces are of significant interest, as they can kill bacteria without the need for antibacterial chemicals. Here, we report on the bactericidal effect of two main lipid components of insect wings epicuticle, palmitic (C16) and stearic (C18) fatty acid films after re-crystallisation on the surface of highly ordered pyrolytic graphite...
July 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28688987/tumor-targeting-by-lentiviral-vectors-combined-with-magnetic-nanoparticlesin-mice
#18
Ester Borroni, Marta Miola, Sara Ferraris, Giulia Ricci, Kristina ŽužekRožman, Nina Kostevšek, Angela Catizone, Lia Rimondini, Maria Prat, Enrica Verné, Antonia Follenzi
Nanomaterials conjugated or complexed with biological moieties such as antibodies, polymers or peptides appear to be suitable not only for drug delivery but also for specific cancer treatment. Here, biocompatible iron oxide magnetic nanoparticles (MNPs) with or without a silica shell coupled with lentiviral vectors (LVs) are proposed as a combined therapeutic approach to specifically target gene expression in a cancer mouse model. Initially, four different MNPs were synthesized and their physical properties were characterized to establish and discriminate their behaviors...
July 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28688986/manganese-oxide-particles-as-cytoprotective-oxygen-generating-agents
#19
Mohammad Hossein Tootoonchi, Mazdak Hashempour, Patricia L Blackwelder, Christopher A Fraker
Cell culture and cellular transplant therapies are adversely affected by oxidative species and radicals. Herein, we present the production of bioactive manganese oxide nanoparticles for the purpose of radical scavenging and cytoprotection. Manganese comprises the core active structure of somatic enzymes that perform the same function, in vivo. Formulated nanoparticles were characterized structurally and surveyed for maximal activity (superoxide scavenging, hydrogen peroxide scavenging with resultant oxygen generation) and minimal cytotoxicity (48-h direct exposure to titrated manganese oxide concentrations)...
July 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28688985/mussel-inspired-plga-polydopamine-core-shell-nanoparticle-for-light-induced-cancer-thermochemotherapy
#20
Huacheng He, Eleni Markoutsa, Yihong Zhan, Jiajia Zhang, Peisheng Xu
Most photothermal converting systems are not biodegradable, which bring the uneasiness when they are administered into human body due to the uncertainty of their fate. Hereby, we developed a mussel-inspired PLGA/polydopamine core-shell nanoparticle for cancer photothermal and chemotherapy. With the help of an anti-EGFR antibody, the nanoparticle could effectively enter head and neck cancer cells and convert near-infrared light to heat to trigger drug release from PLGA core for chemotherapy as well as ablate tumors by the elevated temperature...
July 5, 2017: Acta Biomaterialia
journal
journal
40855
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"