journal
MENU ▼
Read by QxMD icon Read
search

Nanomedicine: Nanotechnology, Biology, and Medicine

journal
https://www.readbyqxmd.com/read/28457935/nf-%C3%AE%C2%BAb-inhibitors-that-prevent-foam-cell-formation-and-atherosclerotic-plaque-accumulation
#1
Jesse D Plotkin, Michael G Elias, Anthony L Dellinger, Christopher L Kepley
The transformation of monocyte-derived macrophages into lipid-laden foam cells is one inflammatory process underlying atherosclerotic disease. Previous studies have demonstrated that fullerene derivatives (FDs) have inflammation-blunting properties. Thus, it was hypothesized that FD could inhibit the transformation process underlying foam cell formation. Fullerene derivatives inhibited the phorbol myristic acid/oxidized low-density lipoprotein-induced differentiation of macrophages into foam cells as determined by lipid staining and morphology...
April 27, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28457934/enhanced-apoptosis-survivin-down-regulation-and-assisted-immunochemotherapy-by-curcumin-loaded-amphiphilic-mixed-micelles-for-subjugating-endometrial-cancer
#2
Animesh Kumar, Vijay Kumar Sirohi, Fatima Anum, Pankaj K Singh, Kanchan Gupta, Diksha Gupta, Shubhini A Saraf, Anila Dwivedi, Manish K Chourasia
Survivin is up-regulated in 83% of endometrial cancer leading to resistance development. As endometrial tumor advances, it also elicits chronic inflammation characterized by increased cytokine secretion and immune cells infiltration. The present study was designed to engineer mixed micellar curcumin loaded formulation for investigating survivin down-regulation, its anti-cancer and cytokine modulatory potential against Ishikawa cell lines, an in-vitro model of endometrial cancer. Flory-Huggins interaction parameter (χpd) was applied to predict the compatibility between curcumin and surfactant mixture...
April 27, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28435136/chitosan-enhances-nanoparticle-delivery-from-the-reproductive-tract-to-target-draining-lymphoid-organs
#3
Jaehyung Park, Renuka Ramanathan, Linhchi Pham, Kim A Woodrow
To prime adaptive immune responses from the female reproductive tract (FRT), particulate antigens must be transported to draining lymph nodes (dLNs) since there are no local organized lymphoid structures equivalent to those found in the respiratory or gastrointestinal tracts. However, little is known about how to safely and effectively navigate successive barriers to transport such as crossing the epithelium and gaining access to migratory cells and lymphatic drainage that provide entry into dLNs. Here, we demonstrate that intravaginal pre-treatment with chitosan significantly facilitates translocation of nanoparticles (NPs) across the multilayered vaginal epithelium to target dLNs...
April 20, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28435135/noninvasive-delivery-of-oligonucleotide-by-penetratin-modified-polyplexes-to-inhibit-protein-expression-of-intraocular-tumor
#4
Lingyu Tai, Chang Liu, Kuan Jiang, Xishan Chen, Gang Wei, Weiyue Lu, Weisan Pan
Our present study aimed to develop an antisense oligonucleotide (ASO) delivery system to achieve gene silencing in intraocular tumor via topical instillation. ASO specific for luciferase was chosen as model drug, polyamidoamine (PG5) was employed to condense ASO, and penetratin (Pene) was used to enhance cellular uptake. Nanoscale PG5/ASO/Pene polyplex was stabilized via noncovalent bonding. In vitro evaluations indicated that PG5/ASO/Pene exhibited improved cell-penetrating and gene silencing ability compared with naked ASO and PG5/ASO...
April 20, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28434932/combinatorial-treatment-of-idiopathic-pulmonary-fibrosis-using-nanoparticles-with-prostaglandin-e-and-sirna-s
#5
O B Garbuzenko, V Ivanova, V Kholodovych, D C Reimer, K R Reuhl, E Yurkow, D Adler, T Minko
Inhalation delivery of prostaglandin E (PGE2) in combination with selected siRNA(s) was proposed for the efficient treatment of idiopathic pulmonary fibrosis (IPF). Nanostructured lipid carriers (NLC) were used as a delivery system for PGE2 with and without siRNAs targeted to MMP3, CCL12, and HIF1Alpha mRNAs. The model of IPF was developed in SKH1 mice by intratracheal administration of bleomycin at a dose of 1.5U/kg. Results showed that NLC-PGE2 in combination with three siRNAs delivered locally to the lungs by inhalation markedly reduced mouse body mass, substantially limited hydroxyproline content in the lungs and disturbances of the mRNAs and protein expression, restricted lung tissue damage and prevented animal mortality...
April 19, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28434931/effect-of-size-and-pegylation-of-liposomes-and-peptide-based-synthetic-lipoproteins-on-tumor-targeting
#6
Jie Tang, Rui Kuai, Wenmin Yuan, Lindsey Drake, James J Moon, Anna Schwendeman
Synthetic high-density lipoprotein nanoparticles (sHDL) are a valuable class of nanomedicines with established animal safety profile, clinical tolerability and therapeutic efficacy for cardiovascular applications. In this study we examined how the scavenger receptor B-I-mediated (SR-BI) tumor-targeting ability of sHDL, long plasma circulation half-life, and small particle size (9.6±0.2nm) impacted sHDL accumulation in SR-BI positive colorectal carcinoma cells, 3D tumor spheroids, and in vivo xenografts. We compared tumor accumulation of sHDL with that of liposomes (LIP, 130...
April 18, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28434930/enhancing-targeted-antibiotic-therapy-via-ph-responsive-solid-lipid-nanoparticles-from-an-acid-cleavable-lipid
#7
Rahul S Kalhapure, Dhiraj R Sikwal, Sanjeev Rambharose, Chunderika Mocktar, Sanil Singh, Linda Bester, Jung Kwon Oh, Jwala Renukuntla, Thirumala Govender
An acid cleavable lipid (SA-3 M) was synthesized and used to develop pH-responsive solid lipid nanoparticles (SLNs) to deliver vancomycin base (VM-FB) to acidic infection sites. The size, polydispersity index and zeta potential of VM-FB_SA-3 M_SLNs were 132.9±9.1nm, 0.159±0.01 and -26±4.4mV respectively, with 57.80±1.1% encapsulation efficiency. VM-FB release was significantly faster at pH6.5 than pH7.4. In vitro antibacterial activity against methicillin-susceptible and resistant Staphylococcus aureus (MSSA and MRSA) revealed that SLNs had enhanced activity at pH6...
April 18, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28428053/discrimination-between-ulcerative-colitis-and-crohn-s-disease-using-phage-display-identified-peptides-and-virus-mimicking-synthetic-nanoparticles
#8
Sonia Facchin, Liboria Digiglio, Renata D'Incà, Elisabetta Casarin, Elisa Dassie, Monica Dettin, Annj Zamuner, Andrea Buda, Michele De Boni, Duilio Della Libera, Alessandra D'Urso, Giacomo Carlo Sturniolo, Margherita Morpurgo
No abstract text is available yet for this article.
April 18, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28428054/modified-nanoparticle-mediated-il-12-immunogene-therapy-for-colon-cancer
#9
Xiaoxiao Liu, Xiang Gao, Songping Zheng, Bilan Wang, Yanyan Li, Chanjuan Zhao, Yagmur Muftuoglu, Song Chen, Ying Li, Haiyan Yao, Hui Sun, Qing Mao, Chao You, Gang Guo, Yuquan Wei
For the past few years, immunotherapy has recently shown considerable clinical benefit in CRC therapy, and the application of immunologic therapies in cancer treatments continues to increase perennially. Interleukin-12, an ideal candidate for tumor immunotherapy, could activate both innate and adaptive immunities. In this study, we developed a novel gene delivery system with a self-assembly method by MPEG-PLA and DOTAP(DMP) with zeta-potential value of 38.5mV and size of 37.5nm. The supernatant of lymphocytes treated with supernatant from Ct26 transfected pIL12 with DMP could inhibit Ct26 cells growth ex vivo...
April 17, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28428052/opening-eyes-to-nanomedicine-where-we-are-challenges-and-expectations-on-nanotherapy-for-diabetic-retinopathy
#10
REVIEW
Elisa J Campos, António Campos, João Martins, António Francisco Ambrósio
People affected with ocular diseases will significantly increase over the next decades, and, consequently, a substantial increase in health costs is expected. Diabetic retinopathy is the most common chronic complication of diabetes. The treatment of eye diseases affecting the posterior segment, such as diabetic retinopathy, is quite challenging due to the anatomy, physiology and biochemistry of the eye. Therefore, the development of new therapeutics for posterior eye diseases has been a major focus of pharmaceutical research in the area of vision sciences...
April 17, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28428051/cell-penetrating-peptide-cgkrk-mediates-efficient-and-widespread-targeting-of-bladder-mucosa-following-focal-injury
#11
James I Griffin, Siu Kit Kevin Cheng, Tomoko Hayashi, Dennis Carson, Manju Saraswathy, Devatha P Nair, Dmitri Simberg
The bladder presents an attractive target for topical drug delivery. The barrier function of the bladder mucosa (urothelium) presents a penetration challenge for small molecules and nanoparticles. We found that focal mechanical injury of the urothelium greatly enhances the binding and penetration of intravesically-administered cell-penetrating peptide CGKRK (Cys-Gly-Lys-Arg-Lys). Notably, the CGKRK bound to the entire urothelium, and the peptide was able to penetrate into the muscular layer. This phenomenon was not dependent on intravesical bleeding and was not caused by an inflammatory response...
April 17, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28414074/a-novel-chemotherapy-drug-free-delivery-system-composed-of-three-therapeutic-aptamers-for-the-treatment-of-prostate-and-breast-cancers-in-vitro-and-in-vivo
#12
Khalil Abnous, Noor Mohammad Danesh, Mohammad Ramezani, Rezvan Yazdian-Robati, Mona Alibolandi, Seyed Mohammad Taghdisi
In this study, a novel chemotherapy drug-free DNA nanocomplex composed of three therapeutic aptamers (IDA, AS1411 and apMNK2F) was designed for treatment of cancer cells. For MTT assay, PC-3 and 4T1 cells (target cells) and CHO cells (nontarget cells) were treated with apMNK2F-AS1411-IDA complex (DNA nanocomplex), as well as AS1411, IDA and apMNK2F alone. Internalization of apMNK2F-AS1411-IDA complex was analyzed by fluorescence imaging and flow cytometry analysis. In the last step, the presented DNA nanocomplex was applied for prohibition of tumor growth in vivo...
April 13, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28412144/quantitative-microscopy-based-measurements-of-circulating-nanoparticle-concentration-using-microliter-blood-volumes
#13
Gregory T Tietjen, Jenna DiRito, Jordan S Pober, W Mark Saltzman
Nanoparticles (NPs) are potential drug delivery vehicles for treatment of a broad range of diseases. Intravenous (IV) administration, the most common form of delivery, is relatively non-invasive and provides (in theory) access throughout the circulatory system. However, in practice, many IV injected NPs are quickly eliminated by specialized phagocytes in the liver and spleen. Consequently, new materials have been developed with the capacity to significantly extend the circulating half-life of IV administered NPs...
April 13, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28412143/thermo-sensitive-assembly-of-the-biomaterial-rep-reduces-hematoma-volume-following-collagenase-induced-intracerebral-hemorrhage-in-rats
#14
Joohyun Park, Jong Youl Kim, Seong-Kyoon Choi, Jae Young Kim, Jae Hwan Kim, Won Bae Jeon, Jong Eun Lee
Intracerebral hemorrhage (ICH) frequently results in severe disabilities and high mortality. RGD-containing elastin-like polypeptide (REP), a modified elastin-like polypeptide (ELP), is a thermally responsive biopolymer. REP has high affinity for cells and is known to show non-immunotoxicity, -cytotoxicity, and -inflammatory responses. Here we found that administration of REP in the acute phase of the ICH rat model reduced the hematoma volume, decreased the number of activated microglia, attenuated the expression of von Willebrand Factor (vWF), and prevented the leakage of immunoglobulin G (IgG) into the cerebral parenchyma without any occlusion of intact microvessels...
April 13, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28404518/nanoparticle-fullerol-alleviates-radiculopathy-via-nlrp3-inflammasome-and-neuropeptides
#15
Li Jin, Mengmeng Ding, Azra Oklopcic, Bayan Aghdasi, Li Xiao, Ziyi Li, Vesna Jevtovic-Todorovic, Xudong Li
The present study aimed to evaluate the analgesic effect of the antioxidant nanoparticle fullerol in a mouse radiculopathy and a dorsal root ganglion (DRG) culture models. Intervertebral disc degeneration causes significant hyperalgesia and nerve inflammation. Pain sensitization and inflammatory reaction were counteracted by fullerol when disc material was bathed in 10 or 100μM of fullerol prior to implantation. Immunohistochemistry showed similar massive IBA1 positive macrophage infiltration surrounding implanted disc material among groups, but IL-1β and IL-6 expression was decreased in fullerol treated group...
April 9, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28400160/intraocular-application-of-gold-nanodisks-optically-tuned-for-optical-coherence-tomography-inhibitory-effect-on-retinal-neovascularization-without-unbearable-toxicity
#16
Hyun Beom Song, Jung-Sub Wi, Dong Hyun Jo, Jin Hyoung Kim, Sang-Won Lee, Tae Geol Lee, Jeong Hun Kim
Bare gold nanospheres have been shown to have anti-angiogenic effects but are optically unfavorable because their resonant wavelength lies in the visible spectrum. Here, we design gold nanodisks with a higher scattering capability than gold nanorods and with a resonant wavelength at near-infrared region - the area where the source of light utilized by optical coherence tomography (OCT) lies. With a physical synthesis system, we then fabricate 160-nm-sized gold nanodisks exhibiting resonant wavelength at 830 nm...
April 8, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28400159/nanotubular-topography-enhances-the-bioactivity-of-titanium-implants
#17
Jingyan Huang, Xinchun Zhang, Wangxiang Yan, Zhipei Chen, Xintao Shuai, Anxun Wang, Yan Wang
Surface modification on titanium implants plays an important role in promoting mesenchymal stem cell (MSC) response to enhance osseointegration persistently. In this study, nano-scale TiO2 nanotube topography (TNT), micro-scale sand blasted-acid etched topography (SLA), and hybrid sand blasted-acid etched/nanotube topography (SLA/TNT) were fabricated on the surfaces of titanium implants. Although the initial cell adherence at 60 min among TNT, SLA and TNT/SLA was not different, SLA and SLA/TNT presented to be rougher and suppressed the proliferation of MSC...
April 8, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28366819/direct-detection-of-nano-scale-extracellular-vesicles-derived-from-inflammation-triggered-endothelial-cells-using-surface-plasmon-resonance
#18
Baharak Hosseinkhani, Nynke van den Akker, Jan D'Haen, Mick Gagliardi, Tom Struys, Ivo Lambrichts, Johannes Waltenberger, Inge Nelissen, Jef Hooyberghs, Daniel G M Molin, Luc Michiels
A major conceptual breakthrough in cell signaling has been the finding of EV as new biomarker shuttles in body fluids. Now, one of the major challenges in using these nanometer-sized biological entities as diagnostic marker is the development of translational methodologies to profile them. SPR offers a promising label-free and real time platform with a high potential for biomarker detection. Therefore, we aimed to develop a uniform SPR methodology to detect specific surface markers on EV derived from patient with CHD...
March 30, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28365418/higher-functionality-of-extracellular-vesicles-isolated-using-size-exclusion-chromatography-compared-to-ultracentrifugation
#19
Emma A Mol, Marie-José Goumans, Pieter A Doevendans, Joost P G Sluijter, Pieter Vader
Extracellular vesicles (EVs) are nano-sized, lipid bilayer-enclosed particles involved in intercellular communication. EVs are increasingly being considered as drug delivery vehicles or as cell-free approach to regenerative medicine. However, one of the major challenges for their clinical application is finding a scalable EV isolation method that yields functional EVs. Although the golden standard for EV isolation is ultracentrifugation (UC), a recent study suggested that isolation using size-exclusion chromatography (SEC) yielded EVs with more intact biophysical properties...
March 30, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28365417/fullerenol-inhibits-the-cross-talk-between-bone-marrow-derived-mesenchymal-stem-cells-and-tumor-cells-by-regulating-mapk-signaling
#20
Xin Nie, Jinglong Tang, Ying Liu, Rong Cai, Qing Miao, Yuliang Zhao, Chunying Chen
The interaction between bone marrow-derived mesenchymal stem cells (BDMSCs) and tumor cells promotes tumor proliferation and metastasis. We found that 4T1 breast cancer cells induced malignant differentiation of BDMSCs and that BDMSCs also affected the growth and metastasis of 4T1 cells. However, when the interaction between BDMSCs and 4T1 cells was attenuated or blocked by C60(OH)22 nanoparticles, tumor growth and metastasis were significantly suppressed. The suppression of metastasis depended on the activation of MAPK signals in the BDMSCs, whereas the underlying pathways were related to a broad range of extracellular responses and were modulated by the secretion of multiple cytokines...
March 30, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
journal
journal
40854
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"