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Nanomedicine: Nanotechnology, Biology, and Medicine

Satish Agrawal, Monika Dwivedi, Hafsa Ahmad, Sangappa Basanna Chadchan, Abhishek Arya, Roshan Sikandar, Shweta Kaushik, Kalyan Mitra, Rajesh Kumar Jha, Anil Kumar Dwivedi
Lapatinib (LPT) is an orally administered drug for the treatment of metastatic breast cancer. For expanding its therapeutic horizon, we have prepared its nanocrystals (LPT-NCs) that were subsequently coated with hyaluronic acid (HA) to produce LPT-HA-NCs. The detailed in-vitro and in-vivo investigation of LPT-HA-NCs showed the superior anticancer activity due to active targeting to CD44 receptors than its counterparts LPT-NCs and free LPT. In the triple negative 4T1 cells induced breast tumor bearing female Balb/C mice; LPT-HA-NCs not only increased the residence time of LPT, but also targeted the tumor, reduced the tumor burden, and increased overall survival...
November 9, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Ching-Yun Hsu, Calvin T Sung, Ibrahim A Aljuffali, Chun-Han Chen, Kai-Yin Hu, Jia-You Fang
The aim of this study was to develop PEGylated phosphatidylcholine (PC)-rich nanovesicles (phosphatiosomes) carrying ciprofloxacin (CIPX) for lung targeting to eradicate extracellular and intracellular methicillin-resistant Staphylococcus aureus (MRSA). Soyaethyl morphonium ethosulfate (SME) was intercalated in the nanovesicle surface with the dual goals of achieving strengthened bactericidal activity of CIPX-loaded phosphatiosomes and delivery to the lungs. The isothermal titration calorimetry (ITC) results proved the strong association of SME phosphatiosomes with pulmonary surfactant...
November 8, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Andisheh Motealleh, Hendrik Hermes, Joachim Jose, Nermin Seda Kehr
To assess chirality-dependent cell adhesion and cell enrichment in an extracellular matrix (ECM)-like model, in this study we created 3D nanocomposite (NC) hydrogels composed of periodic mesoporous organosilica (PMO) functionalized with chiral molecules [NC "homo-hydrogels" (NC hydrogels with one kind of functionalized PMO)]. Additionally, we prepared Janus NC hydrogel by connecting two enantiomorphous NC hydrogels, producing an advanced material that can be used to investigate the effect of opposite enantiomers on the behaviors of healthy and cancer cells in a single biomaterial at the same time and under the same reaction conditions...
November 8, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Damien Carignan, Sabine Herblot, Marie-Ève Laliberté-Gagné, Marilène Bolduc, Michel Duval, Pierre Savard, Denis Leclerc
Rod-shaped virus-like nanoparticles (VLNP) made of papaya mosaic virus (PapMV) coat proteins (CP) self-assembled around a single stranded RNA (ssRNA) were showed to be a TLR7 agonist. Their utilization as an immune modulator in cancer immunotherapy was showed promising. To establish a clinical relevance in human for PapMV VLNP, we showed that stimulation of human peripheral blood mononuclear cells (PBMC) with VLNP induces the secretion of interferon alpha (IFNα) and other pro-inflammatory cytokines and chemokines...
November 8, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Zhichun Shen, Bowen Li, Yajun Liu, Guirong Zheng, Yan Guo, Ruirui Zhao, Kai Jiang, Lulu Fan, Jingwei Shao
Ursolic acid (UA), a natural triterpene acids, is a promising anti-cancer drug due to its inhibitory effect on tumor growth and metastasis. However, clinical translation of UA is limited by its poor water solubility and low bioavailability. To overcome these problems, herein an amphiphilic self-assembly nanodrug composed of UA, lactobionic acid (LA) and low-polyamidoamine (low-PAMAM) dendrimers is developed. This near-spherical nanodrug with a uniform size (~180nm) demonstrated to have an enhanced cytotoxicity against liver cancer SMMC7721 cells, and could attenuate the migration and adhesion of SMMC7721 cells at non-toxic concentrations by suppressing metastasis-related protein MMP-9 expression...
November 8, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Francesca Garello, Amerigo Pagoto, Francesca Arena, Annalisa Buffo, Francesco Blasi, Diego Alberti, Enzo Terreno
The detection of neuroinflammatory processes using innovative and non-invasive imaging techniques is of great help to deeply investigate the onset and progression of neurodegenerative diseases. Since Vascular Cell Adhesion Molecule (VCAM-1) is over expressed at the blood brain barrier in the event of neuroinflammation, the goal of this work was the testing of MRI detectable micelles targeted towards VCAM-1 to visualize inflamed regions in a mouse model of acute neuroinflammation. The developed probe allowed for the early detection of the disease, with higher T1 signal enhancement and more precise localization in comparison to untargeted micelles or to the clinically approved contrast agent MultiHance...
November 8, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Pau Rocas, Yolanda Fernández, Natalia García-Aranda, Laia Foradada, Pilar Calvo, Pablo Avilés, María José Guillén, Simó Schwartz, Josep Rocas, Fernando Albericio, Ibane Abasolo
Glutathione degradable polyurethane-polyurea nanoparticles (PUUa NP) with a disulfide-rich multiwalled structure and a cyclic RGD peptide as a targeting moiety were synthesized, incorporating a very lipophilic chemotherapeutic drug named Plitidepsin. In vitro studies indicated that encapsulated drug maintained and even improved its cytotoxic activity while in vivo toxicity studies revealed that the maximum tolerated dose (MTD) of Plitidepsin could be increased three-fold after encapsulation. We also found that pharmacokinetic parameters such as maximum concentration (Cmax), area under the curve (AUC) and plasma half-life were significantly improved for Plitidepsin loaded in PUUa NP...
November 7, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
David R Wilson, Rupashree Sen, Joel C Sunshine, Drew M Pardoll, Jordan J Green, Young J Kim
Therapeutic cancer vaccines require adjuvants leading to robust type I interferon and proinflammatory cytokine responses in the tumor microenvironment to induce an anti-tumor response. Cyclic dinucleotides (CDNs), a potent Stimulator of Interferon Receptor (STING) agonist, are currently in phase I trials. However, their efficacy may be limited to micromolar concentrations due to the cytosolic residence of STING in the ER membrane. Here we utilized biodegradable, poly(beta-amino ester) (PBAE) nanoparticles to deliver CDNs to the cytosol leading to robust immune response at >100-fold lower extracellular CDN concentrations in vitro...
November 7, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Tianshu Li, Jieyan He, Gabor Horvath, Tomasz Próchnicki, Eicke Latz, Shinji Takeoka
Cationic lipids containing lysine head groups and ditetradecyl, dihexadecyl or dioctadecyl glutamate hydrophobic moieties with/without propyl, pentyl or heptyl spacers were applied for the preparation of cationic liposomes using a simple bath type-sonicator. The size distribution, zeta potential, cellular internalization, and cytotoxicity of the liposomes were characterized, and the innate immune stimulation, e.g., NLRP3 inflammasome activation of human macrophages and THP-1 cells were evaluated by the detection of IL-1ß release...
November 7, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Sarina K Mueller, Angela L Nocera, Benjamin S Bleier
Exosomes are 30-150nm membrane-bound vesicles which are secreted by virtually all cell types. Exosomes have been studied in a wide range of both normal and pathologic human tissues, most notably cancer. The role of exosomes in immune surveillance, non-invasive biomarker sampling, and their potential to act as therapeutic carriers lends particular importance to mucosal barrier derived exosomes. This review focuses specifically on current knowledge regarding exosomes derived from aerodigestive membranes. Specific topics covered include: isolation and characterization techniques, physiological function, protein expression, function as biomarkers of disease, and potential therapeutic uses...
November 7, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Adva Krivitsky, Dina Polyak, Anna Scomparin, Shay Eliyahu, Paula Ofek, Galia Tiram, Hagar Kalinski, Sharon Avkin-Nachum, Natàlia Feiner Gracia, Lorenzo Albertazzi, Ronit Satchi-Fainaro
RNAi therapeutics carried a great promise to the area of personalized medicine: the ability to target "undruggable" oncogenic pathways. Nevertheless, their efficient tumor targeting via systemic administration had not been resolved yet. Amphiphilic alkylated poly(α)glutamate amine (APA) can serve as a cationic carrier to the negatively-charged oligonucleotides. APA polymers complexed with siRNA to form round-shaped, homogenous and reproducible nano-sized polyplexes bearing ~50nm size and slightly negative charge...
November 7, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Manus Biggs, Dimitrios Zeugolis, Abhay Pandit
No abstract text is available yet for this article.
November 2, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Mohammad N Kayyali, Alexander C Wright, Andrew J Ramsey, Jason A Brant, Joel M Stein, Bert W O'Malley, Daqing Li
The development of inner ear gene carriers and delivery systems has enabled genetic defects to be repaired and hearing to be restored in mouse models. Today, promising advances in translational therapies provide confidence that targeted molecular therapy for inner ear diseases will be developed. Unfortunately, the currently available non-invasive modalities, such as Computerized Tomography scan or Magnetic Resonance Imaging provide insufficient resolution to identify most pathologies of the human inner ear, even when the current generation of contrast agents is utilized...
October 24, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Kuan-Jen Bai, Kai-Jen Chuang, Jen-Kun Chen, His-En Hua, Yen-Ling Shen, Wei-Neng Liao, Chii-Hong Lee, Kuan-Yuan Chen, Kang-Yun Lee, Ta-Chih Hsiao, Chih-Hong Pan, Kin-Fai Ho, Hsiao-Chi Chuang
We investigated the effects of nickel oxide nanoparticles (NiONPs) on the pulmonary inflammopathology. NiONPs were intratracheally installed into mice, and lung injury and inflammation were evaluated between 1 and 28 days. NiONPs caused significant increases in LDH, total protein, and IL-6 and a decrease in IL-10 in the BALF and increases in 8-OHdG and caspase-3 in lung tissues at 24 h. Airway inflammation was present in a dose-dependent manner from the upper to lower airways at 24 h of exposure as analyzed by SPECT...
October 23, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Muhan Liu, Sheng Zheng, Xiaojun Zhang, Hongbo Guo, Xiaojing Shi, Xiaoyu Kang, Yawei Qu, Zhenhua Hu, Jie Tian
Apoptosis imaging enables a timely and specific assessment of treatment response in cancer patients. In this study, we applied a probe for positron emission tomography (PET), which served as an optical biomaterial emitting Cerenkov photons, to in vivo optical imaging of tumor apoptosis, in order to evaluate early response to chemotherapy of drug-resistant gastric cancer. (68)Ga-DOTA-Annexin V was prepared as the apoptosis targeting probe. Wild type human gastric adenocarcinoma cell line SGC7901/WT and drug vincristine-resistant variant SGC7901/VCR were used to establish normal and vincristine-resistant xenograft to simulate treatment decision situation...
October 16, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Jian Wang, Zhitao Wu, Guoyu Pan, Junsheng Ni, Fangyuan Xie, Beige Jiang, Lixin Wei, Jie Gao, Weiping Zhou
HAb18G/CD147, an important marker in the progression of hepatocellular carcinoma (HCC), is highly expressed on the surface of HCC cells. To increase the therapeutic efficacy of Doxil (PEGylated liposomal doxorubicin) against HCC, we constructed CD147-targeted doxorubicin-loaded immunoliposomes (Anti-CD147 ILs-DOX) by conjugating F(ab')2 of a CD147-specific monoclonal antibody to DSPE-PEG-MAL, and then inserted the antibody-conjugated polymer to Doxil. Anti-CD147 ILs-DOX delivered DOX to CD147-overexpressing HCC cells specifically and efficiently in vitro and in vivo, resulting in enhanced therapeutic effects than non-targeted controls...
October 15, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Jie Zhou, Lingchang Meng, Chong Sun, Weiran Ye, Chengqun Chen, Bin Du
In order to prevent the aggregation of ICG and enhance its stability, a novel nanoplatform (TiO2:Yb,Ho,F-β-CD@ICG/HA) was designed for NIR-induced phototherapy along with multi-mode imaging(UCL/MRI/Flu). In this nanosysytem: TiO2:Yb,Ho,F was used as upconversion materials and applied in vivo for the first time; β-CD acted as a "protective umbrella" to load separated ICG and avoid the low phototherapy efficiency because of its aggregation; HA was the capping agent of β-CD to prevent ICG unexpected leaking and a target to recognize CD44 receptor...
October 7, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Myung Soo Kim, Matthew J Haney, Yuling Zhao, Dongfen Yuan, Irina Deygen, Natalia L Klyachko, Alexander V Kabanov, Elena V Batrakova
Exosomes have recently emerged as a promising drug delivery system with low immunogenicity, high biocompatibility, and high efficacy of delivery. We demonstrated earlier that macrophage-derived exosomes (exo) loaded with a potent anticancer agent paclitaxel (PTX) represent a novel nanoformulation (exoPTX) that shows high anticancer efficacy in a mouse model of pulmonary metastases. We now report the manufacture of targeted exosome-based formulations with superior structure and therapeutic indices for systemic administration...
October 2, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Shaoqiong Liu, Kazuki Fukushima, Shrinivas Venkataraman, James L Hedrick, Yi Yan Yang
Low molecular weight cationic compounds were synthesized from re-purposed poly(ethylene teraphthalate) (PET) and used to self-assemble into high aspect ratio supramolecular nanofibers for encapsulation and delivery of anionic antibiotics. The antibiotic piperacillin/tazobactam (PT) was successfully loaded into the nanofibers through ionic interaction between anionic PT and the cationic nanofibers without loss of the nanofiber features. These PT-loaded nanofibers demonstrated high loading efficiency and sustained delivery for PT...
September 30, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
Xinxin Yu, Zhaoliang Zhang, Jing Yu, Hao Chen, Xingyi Li
In the present study, we designed and synthesized a hydrogelator comprised of ibuprofen (IPF) and GFFY peptide linked through a cleavable ester bond. We found that the synthesized hydrogelator could spontaneously self-assemble into a hydrogel under a heating-cooling process. When the hydrogel was acted upon by an esterase, IPF was released in a sustained manner. Moreover, the hydrogel had significantly elevated anti-inflammatory efficacy, compared with IPF, in RAW264.7 macrophages. The hydrogel showed good cytocompatibility, as well as excellent ocular biocompatibility when instilled topically...
September 29, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
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