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Nanomedicine: Nanotechnology, Biology, and Medicine

Sergey V Gudkov, Evgenii L Guryev, Andrei B Gapeyev, Mars G Sharapov, Nikolai F Bunkin, Alexey V Shkirin, Tatiana S Zabelina, Alexey P Glinushkin, Mikhail A Sevost'yanov, Konstantin N Belosludtsev, Anatoly V Chernikov, Vadim I Bruskov, Andrey V Zvyagin
Unmodified hydrated С60 fullerene molecules (C60 UHFM) were shown to reduce the formation ROS in water and 8-oxoguanine in DNA upon ionizing radiation impact. C60 UHFM efficiently eliminates long-lived protein radicals arising after irradiation. In irradiated mice C60 UHFM reducing the rate of single/double-strand DNA breaks and amount of chromosomal breaks. The radioprotective activity of C60 UHFM was estimated by the survival rate of animals, the dose modification factor for animal survival was 1.3. Hematological tests showed that C60 UHFM injection in mice prior to irradiation results in a decrement of irradiation-induced leucopenia and thrombocytopenia...
September 18, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Pawandeep Kaur, Arun Kumar Sharma, Debasish Nag, Amlan Das, Satabdi Datta, Arnab Ganguli, Vanshita Goel, Satyendra Rajput, Gopal Chakrabarti, Biswarup Basu, Diptiman Choudhury
Little is known about insulin's wound healing capability in normal as well as diabetic conditions. We here report specific interaction of silver nanoparticles (AgNPs) with insulin by making a ~ 2nm thick coat around the AgNPs and its potent wound healing efficacy. Characterization of the interaction of human insulin with silver nanoparticles showed confirmed alteration of amide-I in insulin whereas amide-II and III remained unaltered. Further, Nanoparticles protein interaction kinetics showed spontaneous interaction at physiological temperature with ΔG, ΔS, Ea and Ka values -7...
September 10, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Mohammad Ali Nilforoushzadeh, Mehrak Zare, Payam Zarrintaj, Effat Alizadeh, Ehsan Taghiabadi, Maryam Heidari-Kharaji, Mohammad Amir Amirkhani, Mohammad Reza Saeb, Masoud Mozafari
Recent progress in hair follicle regeneration and alopecia treatment necessitates revisiting the concepts and approaches. In this sense, there is a need for shedding light on the clinical and surgical therapies benefitting from nanobiomedicine. From this perspective, this review attempts to recognize requirements upon which new hair therapies are grounded; to underline shortcomings and opportunities associated with recent advanced strategies for hair regeneration; and most critically to look over hair regeneration from nanomaterials and pluripotent stem cell standpoint...
September 7, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Man Li, Yuting Yang, Jiaojie Wei, Xingli Cun, Zhengze Lu, Yue Qiu, Zhirong Zhang, Qin He
Cholesterol facilitated the formation of T cell receptor on cytotoxic CD8+ T lymphocytes (CTLs). However, the activation of CD8+ T cells always resulted in the upregulation of acetyl-CoA acetyltransferase-1 (ACAT-1) and enhanced the esterification of cholesterol. To relieve the suppression on CD8+ T cells, an ACAT-1 inhibitor avasimibe was combined with chemo-immunotherapy. Paclitaxel and immunoadjuvant αGC were co-encapsulated in liposomes modified with pH sensitive TH peptide (PTX/αGC-TH-Lip). After intravenous injections, the combination of avasimibe significantly elevated the free cholesterol level and relieved the inhibition of CD8+ T cells caused by PTX/αGC-TH-Lip, leading to enhanced CTL responses and anti-tumor effects of PTX/αGC-TH-Lip in B16F10 melanoma xenograft and lung metastasis models...
September 5, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Pingyi Zhang, Subo Li, Shikun Zhang, Xue Zhang, Luming Wan, Zhimin Yun, Shouping Ji, Feng Gong, Manna Huang, Leilei Wang, Xinhai Zhu, Yingxia Tan, Yiqian Wan
Hemostats, which are used for immediate intervention during internal hemorrhage in order to reduce resulting mortality and morbidity, are relatively rare. Here, we describe novel intravenous nanoparticles (CPG-NPs-2000) with chitosan succinate (CSS) as cores, polyethylene glycol (PEG-2000) as spacers and a glycine-arginine-glycine-aspartic acid-serine (GRGDS) peptide as targeted, active hemostatic motifs. CPG-NPs-2000 displayed significant hemostatic efficacy, compared to the saline control, CSS nanoparticles, and tranexamic acid in liver trauma rat models...
September 5, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Marilène Bolduc, Mariana Baz, Marie-Ève Laliberté-Gagné, Damien Carignan, Caroline Garneau, Alexis Russel, Guy Boivin, Pierre Savard, Denis Leclerc
Influenza virus infections are a significant public threat and the best approach to prevent them is through vaccination. Because of the perpetual changes of circulating influenza strains, the efficacy of influenza vaccines rarely exceeds 50%. To improve the protection efficacy, we have designed a novel vaccine formulation that shows a broad range of protection. The formulation is made of the matrix protein 2 (M2e) and the nucleoprotein (NP) antigens. The multimerization of NP into nanoparticles improved significantly the immune response to NP...
September 5, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Saiping Jiang, Shujuan Li, Jingbo Hu, Xiaoling Xu, Xiaojuan Wang, Xuqi Kang, Jing Qi, Xiaoyang Lu, Jiahui Wu, Yongzhong Du, Yonghong Xiao
Effective treatment for acute lung injury (ALI) is in high demand. Lung-targeted ternary nanoparticles containing anti-intercellular adhesion molecule-1 (ICAM-1) antibody-conjugated simvastatin-loaded nanostructured lipid carrier (ICAM/NLC), protamine (Pro), and angiopoietin-1 (Ang-1) gene (ICAM-NLC/Pro/Ang) were developed for ALI therapy. The ternary nanoparticles with different weight ratios of ICAM-NLC to Ang-1 gene were prepared via charge interaction. The anti-ICAM-1 antibody-conjugated ternary nanoparticles exhibited higher cellular uptake and transfection efficiency (from 26...
September 4, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Daniel Gonzalez-Carter, Zhan Yuin Ong, Catriona M McGilvery, Iain E Dunlop, David T Dexter, Alexandra E Porter
The blood-brain barrier (BBB) is a protective endothelial barrier lining the brain microvasculature which prevents brain delivery of therapies against brain diseases. Hence, there is an urgent need to develop vehicles which efficiently penetrate the BBB to deliver therapies into the brain. The drug L-DOPA efficiently and specifically crosses the BBB via the large neutral amino acid transporter (LAT)-1 protein to enter the brain. Thus, we synthesized L-DOPA-functionalized multi-branched nanoflower-like gold nanoparticles (L-DOPA-AuNF) using a seed-mediated method involving catechols as a direct reducing-cum-capping agent, and examined their ability to cross the BBB to act as brain-penetrating nanovehicles...
September 3, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Wolfram C Poller, Melanie Pieber, Philipp Boehm-Sturm, Evelyn Ramberger, Vasileios Karampelas, Konstantin Möller, Moritz Schleicher, Frank Wiekhorst, Norbert Löwa, Susanne Wagner, Jörg Schnorr, Matthias Taupitz, Karl Stangl, Verena Stangl, Antje Ludwig
We investigated the biotransformation of very small superparamagnetic iron oxide nanoparticles (VSOP) in atherosclerotic LDLR-/- mice. Transmission electron microscopy revealed an uptake of VSOP not only by macrophages but also by endothelial cells in liver, spleen, and atherosclerotic lesions and their accumulation in the lysosomal compartment. Using magnetic particle spectroscopy (MPS), we show that the majority of VSOP's superparamagnetic iron was degraded within 28 days. MPS spectrum shape indicated changes in the magnetic properties of VSOP during the biodegradation process...
September 1, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Vijay Parikh, Juned Kadiwala, Araida Hidalgo Bastida, Cathy Holt, Mohammad Sanami, Mohsen Miraftab, Rameen Shakur, May Azzawi
There is an acute clinical need for small-diameter vascular grafts as a treatment option for cardiovascular disease. Here, we used an intelligent design system to recreate the natural structure and hemodynamics of small arteries. Nano-fibrous tubular scaffolds were fabricated from blends of polyvinyl alcohol and gelatin with inner helices to allow a near physiological spiral flow profile, using the electrospinning technique. Human coronary artery endothelial cells (ECs) were seeded on the inner surface and their viability, distribution, gene expression of mechanosensitive and adhesion molecules compared to that in conventional scaffolds, under static and flow conditions...
August 31, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Vinay Sridhar, Ram Gaud, Amrita Bajaj, Sarika Wairkar
Selegiline, a well-known anti-Parkinson agent, is reported to be associated with poor oral bioavailability and safety. Therefore, we formulated selegiline as chitosan nanoparticles and evaluated its pharmacokinetics and pharmacodynamics after intranasal administration to rats relative to those after oral administration. The optimized formulation exhibited spherical nanoparticles with more than 90% drug loading and steady in vitro and ex vivo drug release. Selegiline concentrations in the brain and plasma were 20- and 12-fold higher, respectively, after intranasal administration than after oral administration...
August 30, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Yanan Song, Zheyong Huang, Xin Liu, Zhiqing Pang, Jing Chen, Hongbo Yang, Ning Zhang, Zhonglian Cao, Ming Liu, Jiatian Cao, Chenguang Li, Xiangdong Yang, Hui Gong, Juying Qian, Junbo Ge
Although certain success has been achieved in atherosclerosis treatment, tremendous challenges remain in developing more efficient strategies to treat atherosclerosis. Platelets have inherent affinity to plaques and naturally home to atherosclerotic sites. Rapamycin features potent anti-atherosclerosis effect, but its clinical utility is limited by its low concentration at the atherosclerotic site and severe systemic toxicity. In the present study, we used platelet membrane-coated nanoparticles (PNP) as a targeted drug delivery platform to treat atherosclerosis through mimicking platelets' inherent targeting to plaques...
August 30, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Minori Kawai, Takashi Nakamura, Naoya Miura, Mio Maeta, Hiroki Tanaka, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe, Kota Tange, Yuta Nakai, Hiroki Yoshioka, Hideyoshi Harashima, Hidetaka Akita
Cytoplasmic DNA triggers cellular immunity via activating the stimulator of interferon genes pathway. Since DNA is degradable and membrane impermeable, delivery system would permit cytoplasmic delivery by destabilizing the endosomal membrane for the use as an adjuvant. Herein, we report on the development of a plasmid DNA (pDNA)-encapsulating lipid nanoparticle (LNP). The structural components include an SS-cleavable and pH-activated lipid-like material that mounts vitamin E as a hydrophobic scaffold, and dual sensing motifs that are responsive to the intracellular environment (ssPalmE)...
August 29, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Qin Wang, Ai Xiao, Yiming Liu, Qian Zou, Qing Zhou, Hong Wang, Xiangliang Yang, Chuansheng Zheng, Yajiang Yang, Yanhong Zhu
It is crucial to develop dual or multi-modal self-imaging embolic microspheres to evaluate the effects of transcatheter arterial embolization therapy of tumor. However, the preparation of such hybrid microspheres always involved in multiple steps or complicated conditions. Here, poly(vinyl alcohol) (PVA) hybrid microspheres with dual-modal T1 /T2 -weighted magnetic resonance imaging (MRI) have been prepared based on microfluidic technique in one step. Gd2 O3 and Fe3 O4 nanoparticles with a size of ~5 nm act as T1 - and T2 -weighted MRI contrast agents, respectively, which are simultaneously in-situ synthesized in the PVA matrix via the reaction of metal ions and alkali with PVA chains as a soft template...
August 25, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Fawad Ur Rehman, Tianyu Du, Sana Shaikh, Xuerui Jiang, Yun Chen, Xiaoqi Li, Huan Yi, Jiang Hui, Baoan Chen, Matthias Selke, Xuemei Wang
Timely detection is crucial for successful treatment of cancer. The current study describes a new approach that involves utilization of the tumor cell environment for bioimaging with in-situ biosynthesized nanoscale gold and iron probes and subsequent dissemination of Au-Fe nanoclusters from cargo exosomes within the circulatory system. We have isolated the Au-Fe cargo exosomes from the blood of the treated murine models after in situ biosyntheses from their respective pre-ionic solutions (HAuCl4 , FeCl2 ), whereas Na2 SeO3 supplementation added into Au lethal effect...
August 18, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Sebastian Kallus, Bernhard Englinger, Julia Senkiv, Anna Laemmerer, Petra Heffeter, Walter Berger, Christian R Kowol, Bernhard K Keppler
Fibroblast growth factor receptor (FGFR) inhibitors like ponatinib and nintedanib are clinically approved for defined cancer patient cohorts but often exert dose-limiting adverse effects. Hence, we encapsulated the FGFR inhibitors ponatinib, PD173074, and nintedanib into polylactic acid nanoparticles and liposomes to enable increased tumor accumulation/specificity and reduce side effects. Different methods of drug loading were tested and the resulting formulations compared regarding average size distribution as well as encapsulation efficiency...
August 16, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Janarthanan Gopinathan, Mamatha Muraleedharan Pillai, Sivanandam Shanthakumari, Singaram Gnanapoongothai, Beliyur Krishna Dinakar Rai, Kulasekaran Santosh Sahanand, Rajendran Selvakumar, Amitava Bhattacharyya
We developed customizable biomolecule functionalized 3D poly-ε-caprolactone (PCL) scaffolds reinforced with carbon nanofibers (CNF) for human meniscal tissue engineering. 3D nanocomposite scaffolds exhibited commendable mechanical integrity and electrical properties with augmented cytocompatibility. Especially, the functionalized 3D (10wt% CNF) scaffolds showed ~363% increase in compressive moduli compared to the pristine PCL. In dynamic mechanical analysis, these scaffolds achieved highest value (~42 MPa at 10 Hz) among all tested scaffolds including pristine PCL and human menisci (33, 41, 56 years)...
August 4, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Yanzhi Liu, Zhenshan Jia, Mohammed P Akhter, Xiang Gao, Xiaobei Wang, Xiaoyan Wang, Gang Zhao, Xin Wei, You Zhou, Xiuli Wang, Curtis W Hartman, Edward V Fehringer, Liao Cui, Dong Wang
Delayed fracture union is a significant clinical challenge in orthopedic practice. There are few non-surgical therapeutic options for this pathology. To address this challenge, we have developed a bone-targeting liposome (BTL) formulation of salvianic acid A (SAA), a potent bone anabolic agent, for improved treatment of delayed fracture union. Using pyrophosphorylated cholesterol as the targeting ligand, the liposome formulation (SAA-BTL) has demonstrated strong affinity to hydroxyapatite in vitro, and to bones in vivo...
August 2, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Mathias Viard, Henry Reichard, Bruce A Shapiro, Farukh A Durrani, Aimee J Marko, R Michelle Watson, Ravindra K Pandey, Anu Puri
Advances in in vivo stability and preferential tumor uptake of cancer nanomedicine are warranted for effective chemotherapy. Here, we describe a novel nanoformulation using an unconventional polymeric tubule-forming phospholipid, DC8,9 PC. We report that DC8,9 PC transitions to stable vesicles (LNPs) in the presence of PEGylated lipid (DSPE-PEG2000); the resulting DC8,9 PC:DSPE-PEG2000 LNPs efficiently included a hydrophobic PDT drug, HPPH. Remarkably, these LNPs incorporated unusually high DSPE-PEG2000 concentrations; LNP10 -HPPH and LNP20 -HPPH (10 & 20 mol% PEGylated lipid, respectively) exhibited >90% serum stability at 37 °C...
July 27, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Yang Du, Kelong Fan, Hejun Zhang, Li Li, Peixia Wang, Jiuyang He, Shigang Ding, Xiyun Yan, Jie Tian
Optical imaging technologies improve clinical diagnostic accuracy of early gastric cancer (EGC). However, there was a lack of imaging agents exhibiting molecular specificity for EGCs. Here, we employed the dye labeled human heavy-chain ferritin (HFn) as imaging nanoprobe, which recognizes tumor biomarker transferrin receptor 1 (TfR1), to enable specific EGC imaging using confocal laser endomicroscopy (CLE). TfR1 expression was initially examined in vitro in gastric tumor cells and in vivo through whole-body fluorescence and CLE imaging in tumor-bearing mice...
July 26, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
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