Read by QxMD icon Read


Matteo Minghetti, Kristin Schirmer
To understand conditions affecting bioavailability and toxicity of citrate-coated silver nanoparticles (cit-AgNP) and dissolved silver at the luminal enterocyte interface, we exposed rainbow trout (Oncorhynchus mykiss) gut cells (RTgutGC) in media of contrasting composition: two amino acid-containing media, one of which was supplemented with proteins, as can be expected during digestion; and two protein and amino acid-free media contrasting low and high chloride content, as can be expected in the lumen of fish adapting to freshwater or seawater, respectively...
October 21, 2016: Nanotoxicology
Mirlande Présumé, Angélique Simon-Deckers, Céline Tomkiewicz-Raulet, Béatrice Le Grand, Jeanne Tran Van Nhieu, Gregory Beaune, Olivier Duruphty, Jean Doucet, Xavier Coumoul, Jean-Claude Pairon, Jorge Boczkowski, Sophie Lanone, Pascal Andujar
In spite of the great promises that the development of nanotechnologies can offer, concerns regarding potential adverse health effects of occupational exposure to nanoparticle (NP) is raised. We recently identified metal oxide NP in lung tissue sections of welders, located inside macrophages infiltrated in fibrous regions. This suggests a role of these NP in the lung alterations observed in welders. We therefore designed a study aimed to investigate the pulmonary effects, in mice, of repeated exposure to NP administered at occupationally relevant doses...
October 18, 2016: Nanotoxicology
Minne B Heringa, Liesbeth Geraets, Jan C H van Eijkeren, Rob J Vandebriel, Wim H de Jong, Agnes G Oomen
Titanium dioxide white pigment consists of particles of various sizes, from which a fraction is in the nano range (<100 nm). It is applied in food as additive E 171 as well as in other products, such as food supplements and toothpaste. Here, we assessed whether a human health risk can be expected from oral ingestion of these titanium dioxide nanoparticles (TiO2 NPs), based on currently available information. Human health risks were assessed using two different approaches: Approach 1, based on intake, i...
October 11, 2016: Nanotoxicology
Géraldine Klein, Christelle Mathé, Mathilde Biola-Clier, Stéphanie Devineau, Emilie Drouineau, Elie Hatem, Laurent Marichal, Béatrice Alonso, Jean-Charles Gaillard, Gilles Lagniel, Jean Armengaud, Marie Carrière, Stéphane Chédin, Yves Boulard, Serge Pin, Jean-Philippe Renault, Jean-Christophe Aude, Jean Labarre
Upon contact with biological fluids, nanoparticles (NPs) are readily coated by cellular compounds, particularly proteins, which are determining factors for the localization and toxicity of NPs in the organism. Here, we improved a methodological approach to identify proteins that adsorb on silica NPs with high affinity. Using large-scale proteomics and mixtures of soluble proteins prepared either from yeast cells or from alveolar human cells, we observed that proteins with large unstructured region(s) are more prone to bind on silica NPs...
October 5, 2016: Nanotoxicology
Carlotta Bianco, Maaike J Visser, Olivier A Pluut, Vesna Svetličić, Galja Pletikapić, Ivone Jakasa, Christoph Riethmuller, Gianpiero Adami, Francesca Larese Filon, Diane Schwegler-Berry, Aleksandr B Stefaniak, Sanja Kezic
Silver is increasingly being used in garments to exploit its antibacterial properties. Information on the presence of silver nanoparticles (AgNPs) in garments and their in vivo penetration across healthy and impaired skin from use is limited. We investigated the presence of AgNPs in a silver containing garment and in the stratum corneum (SC) of healthy subjects (CTRLs) and individuals with atopic dermatitis (AD). Seven CTRLs and seven AD patients wore a silver sleeve (13% Ag w/w) 8 h/day for five days on a forearm and a placebo sleeve on the other forearm...
October 5, 2016: Nanotoxicology
Amy M Holmes, Julian Lim, Hauke Studier, Michael S Roberts
The use of silver nanoparticles (Ag NPs) within the healthcare sector and consumer products is rapidly increasing. There are now a range of diverse-shaped Ag NPs that are commercially available and many of the products containing nanosilver are topically applied to human skin. Currently, there is limited data on the extent to which the antimicrobial efficacy and cytotoxicity of Ag NPs is related to their shape and how the shape of the Ag NPs affects their distribution in both intact and burn wounded human skin after topical application...
October 5, 2016: Nanotoxicology
Kerstin Hund-Rinke, Anders Baun, Denisa Cupi, Teresa F Fernandes, Richard Handy, John H Kinross, José M Navas, Willie Peijnenburg, Karsten Schlich, Benjamin J Shaw, Janeck J Scott-Fordsmand
Regulatory ecotoxicity testing of chemicals is of societal importance and a large effort is undertaken at the OECD to ensure that OECD test guidelines (TGs) for nanomaterials (NMs) are available. Significant progress to support the adaptation of selected TGs to NMs was achieved in the context of the project MARINA ( ) funded within the 7th European Framework Program. Eight OECD TGs were adapted based on the testing of at least one ion-releasing NM (Ag) and two inert NMs (TiO2). With the materials applied, two main variants of NMs (ion releasing vs...
September 20, 2016: Nanotoxicology
Cathy Rompelberg, Minne B Heringa, Gerda van Donkersgoed, José Drijvers, Agnes Roos, Susanne Westenbrink, Ruud Peters, Greet van Bemmel, Walter Brand, Agnes G Oomen
Titanium dioxide (TiO2) is commonly applied to enhance the white colour and brightness of food products. TiO2 is also used as white pigment in other products such as toothpaste. A small fraction of the pigment is known to be present as nanoparticles (NPs). Recent studies with TiO2 NPs indicate that these particles can have toxic effects. In this paper, we aimed to estimate the oral intake of TiO2 and its NPs from food, food supplements and toothpaste in the Dutch population aged 2 to over 70 years by combining data on food consumption and supplement intake with concentrations of Ti and TiO2 NPs in food products and supplements...
September 13, 2016: Nanotoxicology
Brian C Sayers, Dori R Germolec, Nigel J Walker, Kelly A Shipkowski, Matthew D Stout, Mark F Cesta, Joseph H Roycroft, Kimber L White, Gregory L Baker, Jeffrey A Dill, Matthew J Smith
C60 fullerene (C60), or buckminsterfullerene, is a spherical arrangement of 60 carbon atoms, having a diameter of approximately 1 nm, and is produced naturally as a by-product of combustion. Due to its small size, C60 has attracted much attention for use in a variety of applications; however insufficient information is available regarding its toxicological effects. The effects on respiratory toxicity and immunotoxicity of C60 aggregates (50 nm [nano-C60] and 1 μm [micro-C60] diameter) were examined in B6C3F1/N mice and Wistar Han rats after nose-only inhalation for 13 weeks...
September 12, 2016: Nanotoxicology
K Loza, I Föhring, J Bünger, G A Westphal, M Köller, M Epple, C Sengstock
The inhalation of particles and their exposure to the bronchi and alveoli constitute a major public health risk. Chemical as well as particle-related properties are important factors for the biological response but are difficult to separate from each other. Barium sulfate is a completely inert chemical compound, therefore it is ideally suited to separate these two factors. The biological response of rat alveolar macrophages (NR8383) was analyzed after exposure to barium sulfate particles with three different diameters (40 nm, 270 nm, and 1...
September 10, 2016: Nanotoxicology
Yunli Zhao, Lingtong Zhi, Qiuli Wu, Yonglin Yu, Qiqing Sun, Dayong Wang
Biological barrier plays a crucial role for organisms against the possible toxicity from engineered nanomaterials (ENMs). Graphene oxide (GO) has been proven to cause potential toxicity on organisms. However, the molecular mechanisms for intestinal barrier of animals against GO toxicity are largely unclear. Using in vivo assay system of Caenorhabditis elegans, we found that mutation of genes encoding core p38 mitogen-activated protein kinase (MAPK) signaling pathway caused susceptible property to GO toxicity and enhanced translocation of GO into the body of nematodes...
September 10, 2016: Nanotoxicology
Meike van der Zande, Anna K Undas, Evelien Kramer, Marco P Monopoli, Ruud J Peters, David Garry, Elsa C Antunes Fernandes, Peter J Hendriksen, Hans J P Marvin, Ad A Peijnenburg, Hans Bouwmeester
The mode of action of silver nanoparticles (AgNPs) is suggested to be exerted through both Ag(+) and AgNP dependent mechanisms. Ingestion is one of the major NP exposure routes, and potential effects are often studied using Caco-2 cells, a well-established model for the gut epithelium. MCF-7 cells are epithelial breast cancer cells with extensive well-characterized toxicogenomics profiles. In the present study, we aimed to gain a deeper understanding of the cellular molecular responses in Caco-2 and MCF-7 cells after AgNP exposure in order to evaluate whether epithelial cells derived from different tissues demonstrated similar responses...
September 6, 2016: Nanotoxicology
Jiyoung Jeong, Seonghan Lee, Sung-Hyun Kim, Youngju Han, Dong-Keon Lee, Jun-Young Yang, Jayoung Jeong, Changhyun Roh, Yun Suk Huh, Wan-Seob Cho
Although surface area metric was suggested as an appropriate dose metric for acute lung inflammation of NPs, it might not be effective for fast-dissolving NPs because they lose their reactive surface when dissolved in the phagolysosomes. Herein, we evaluated the dose metric for fast-dissolving NPs using a rat intratracheal instillation model. A panel of fast-dissolving NPs (CoO, CuO, and ZnO) and their constituent metal ions (CoCl2, CuCl2, and ZnCl2) were compiled and each compound was intratracheally instilled into the lungs of female Wistar rats at the same molar concentrations in the NP doses (40, 100, and 400 μg/rat)...
August 25, 2016: Nanotoxicology
Sarah Deville, Birgit Baré, Jordi Piella, Kristof Tirez, Peter Hoet, Marco Monopoli, Kenneth Dawson, Victor F Puntes, Inge Nelissen
Despite many investigations have focused on the pristine toxicity of gold nanoparticles (GNPs), little is known about the outcome of co-exposure and interaction of GNPs with heavy metals which can possibly detoxify or potentiate them. Here, the combined exposure of nickel (II) sulphate (NiSO4) and GNPs on the maturation response of dendritic cells (DC) was explored. Exposure to GNPs or NiSO4 separately induced cell activation. When cells were exposed to a mixture of both, however, the observed cell activation pattern indicated a competitive rather than an additive effect of both inducers with levels similar to those induced by NiSO4 alone...
August 23, 2016: Nanotoxicology
J H Fine, G S Bondy, L Coady, B Pearce, N Ross, A F Tayabali, S Halappanavar, D Caldwell, I Curran, D E Lefebvre
Humans could become exposed to carbon black nanoparticles (CBNPs) in consumer products or an occupational setting. In rodent models, acute respiratory, subcutaneous, and direct immune cell exposure to CBNPs has been shown to enhance allergic sensitization to co-administered ovalbumin (OVA) protein from chicken egg. However, little is known about the effects of ingested CBNPs on immunological responses and oral tolerance to food antigens. We hypothesized that ingestion of CBNPs would enhance the development of food allergy to OVA...
August 18, 2016: Nanotoxicology
Frank Seitz, Ricki R Rosenfeldt, Marie Müller, Simon Lüderwald, Ralf Schulz, Mirco Bundschuh
Nanoparticles' fate is amongst other parameters determined by the quantity and quality of natural organic matter (NOM). Consequently, the ecotoxicity of nanoparticles is modified, while only little information is available on the NOM characteristics triggering this interplay. This study systematically examined how NOM quantity and quality influences the acute ecotoxicity of titanium dioxide nanoparticles (nTiO2) towards Daphnia magna. Therefore, two nTiO2 products (A-100 and P25; ∼100 nm) were investigated in combination with seven NOM types of variable quality at four levels each (up to 4...
August 8, 2016: Nanotoxicology
Jiejun Gao, Cecon T Mahapatra, Christopher D Mapes, Maria Khlebnikova, Alexander Wei, Marisol S Sepúlveda
Nanoparticles (NPs, 1-100 nm) can enter the environment and result in exposure to humans and other organisms leading to potential adverse health effects. The aim of the present study is to evaluate the effects of early life exposure to polyvinylpyrrolidone-coated silver nanoparticles (PVP-AgNPs, 50 nm), particularly with respect to vascular toxicity on zebrafish embryos and larvae (Danio rerio). Previously published data has suggested that PVP-AgNP exposure can inhibit the expression of genes within the vascular endothelial growth factor (VEGF) signaling pathway, leading to delayed and abnormal vascular development...
November 2016: Nanotoxicology
Laura Anspach, Ronald E Unger, Christoph Brochhausen, Matthew I Gibson, Harm-Anton Klok, C James Kirkpatrick, Christian Freese
A library of polymer-coated gold nanoparticles (AuNPs) differing in size and surface modifications was examined for uptake and induction of cellular stress responses in the endoplasmic reticulum (ER stress) in human brain endothelial cells (hCMEC/D3). ER stress is known to affect the physiology of endothelial cells (ECs) and may lead to inflammation or apoptosis. Thus, even if applied at non-cytotoxic concentrations ER stress caused by nanoparticles should be prevented to reduce the risk of vascular diseases and negative effects on the integrity of barriers (e...
November 2016: Nanotoxicology
Harry Whitwell, Rose-Marie Mackay, Christine Elgy, Cliff Morgan, Mark Griffiths, Howard Clark, Paul Skipp, Jens Madsen
The formation of protein coronae on nanoparticles (NPs) has been investigated almost exclusively in serum, despite the prevailing route of exposure being inhalation of airborne particles. In addition, an increasing number of nanomedicines, that exploit the airways as the site of delivery, are undergoing medical trials. An understanding of the effects of NPs on the airways is therefore required. To further this field, we have described the corona formed on polystyrene (PS) particles with different surface modifications and on titanium dioxide particles when incubated in human bronchoalveolar lavage fluid (BALF) from patients with pulmonary alveolar proteinosis (PAP)...
November 2016: Nanotoxicology
Ioannis G Theodorou, Pakatip Ruenraroengsak, Andrew Gow, Stephan Schwander, Junfeng Jim Zhang, Kian Fan Chung, Teresa D Tetley, Mary P Ryan, Alexandra E Porter
Inhaled nanoparticles (NPs) have high-deposition rates in the alveolar region of the lung but the effects of pulmonary surfactant (PS) on nanoparticle bioreactivity are unclear. Here, the impact of PS on the stability and dissolution of ZnO nanowires (ZnONWs) was investigated, and linked with their bioreactivity in vitro with human alveolar epithelial type 1-like cells (TT1). Pre-incubation of ZnONWs with Curosurf® (a natural porcine PS) decreased their dissolution at acidic pH, through the formation of a phospholipid corona...
November 2016: Nanotoxicology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"