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Nanotoxicology

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https://www.readbyqxmd.com/read/28044463/silver-nanoparticles-induced-reactive-oxygen-species-via-photosynthetic-energy-transport-imbalance-in-an-aquatic-plant
#1
Hong Sheng Jiang, Li Yan Yin, Na Na Ren, Su Ting Zhao, Zhi Li, Yongwei Zhi, Hui Shao, Wei Li, Brigitte Gontero
The rapid growth in silver nanoparticles (AgNPs) commercialization has increased environmental exposure, including aquatic ecosystem. It has been reported that the AgNPs have damaging effects on photosynthesis and induce oxidative stress, but the toxic mechanism of AgNPs is still a matter of debate. In the present study, on the model aquatic higher plant Spirodela polyrhiza, we found that AgNPs affect photosynthesis and significantly inhibit Photosystem II (PSII) maximum quantum yield (Fv/Fm) and effective quantum yield (ΦPSII)...
January 19, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28098511/hemodynamic-effects-of-hpma-copolymer-based-doxorubicin-conjugate-a-randomized-controlled-and-comparative-spectral-study-in-conscious-rats
#2
Hoay Yan Cheah, Olivera Šarenac, Juan J Arroyo, Marko Vasić, Maja Lozić, Sofija Glumac, See Ziau Hoe, Charles Colin Thomas Hindmarch, David Murphy, Lik Voon Kiew, Hong Boon Lee, Marίa J Vicent, Lip Yong Chung, Nina Japundžić-Žigon
Conjugation of Doxorubicin (DOX) to N-(2-Hydroxypropyl) methylacrylamide copolymer (HPMA) has significantly reduced the DOX-associated cardiotoxicity. However, the reports on the impact of HPMA-DOX conjugates on the cardiovascular system such as blood pressure (BP) and heart rate (HR) were in restrained animals using tail cuff and/or other methods that lacked the resolution and sensitivity. Herein, we employed radiotelemetric-spectral-echocardiography approach to further understand the in vivo cardiovascular hemodynamics and variability post administration of free DOX and HPMA-DOX...
January 18, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28091127/amino-modified-polystyrene-nanoparticles-affect-signalling-pathways-of-the-sea-urchin-paracentrotus-lividus-embryos
#3
Annalisa Pinsino, Elisa Bergami, Camilla Della Torre, Maria Luisa Vannuccini, Piero Addis, Marco Secci, Kenneth A Dawson, Valeria Matranga, Ilaria Corsi
Polystyrene nanoparticles have been shown to pose serious risk to marine organisms including sea urchin embryos based on their surface properties and consequently behaviour in natural sea water. The aim of this study is to investigate the toxicity pathways of amino polystyrene nanoparticles (PS-NH2, 50 nm) in Paracentrotus lividus embryos in terms of development and signalling at both protein and gene levels. Two sub-lethal concentrations of 3 and 4 µg/mL of PS-NH2 were used to expose sea urchin embryos in natural sea water (PS-NH2 as aggregates of 143 ± 5 nm)...
January 16, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28024456/thrombospondin-1-mediates-multi-walled-carbon-nanotube-induced-impairment-of-arteriolar-dilation
#4
W Kyle Mandler, Timothy R Nurkiewicz, Dale W Porter, I Mark Olfert
Pulmonary exposure to multi-walled carbon nanotubes (MWCNT) has been shown to disrupt endothelium-dependent arteriolar dilation in the peripheral microcirculation. The molecular mechanisms behind these arteriolar disruptions have yet to be fully elucidated. The secreted matricellular matrix protein thrombospondin-1 (TSP-1) is capable of moderating arteriolar vasodilation by inhibiting soluble guanylate cyclase activity. We hypothesized that TSP-1 may be a link between nanomaterial exposure and observed peripheral microvascular dysfunction...
January 11, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28055265/nanomaterial-induced-cell-death-in-pulmonary-and-hepatic-cells-following-exposure-to-three-different-metallic-materials-the-role-of-autophagy-and-apoptosis
#5
Ali Kermanizadeh, Kim Jantzen, Michael B Ward, Jon Ambæk Durhuus, Lene Juel Rasmussen, Steffen Loft, Peter Møller
Autophagy is the catabolic process involving the sequestration of the cytoplasm within double-membrane vesicles, which fuse with lysosomes to form autolysosomes in which autophagic targets are degraded. Since most endocytic routes of nanomaterial uptake converge upon the lysosome and the possibility that autophagy induction by NMs may be an attempt by the cell to self-preserve following the external challenge, this study investigated the role of autophagy following exposure to a panel of widely used metal-based NMs with high toxicity (Ag and ZnO) or low toxicity (TiO2) in a pulmonary (A549) and hepatic (HepG2) cell line...
January 5, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28055263/digestive-cell-lysosomes-as-main-targets-for-ag-accumulation-and-toxicity-in-marine-mussels-mytilus-galloprovincialis-exposed-to-maltose-stabilised-ag-nanoparticles-of-different-sizes
#6
A Jimeno-Romero, E Bilbao, U Izagirre, M P Cajaraville, I Marigómez, M Soto
Bioavailability and toxicity of maltose-stabilised AgNPs of different sizes (20, 40 and 100 nm) in mussels were compared with bulk and aqueous forms of the metal through a two-tier experimental approach. In the 1(st) tier, mussels were exposed for 3 d to a range of concentrations (0.75, 75, 750 µg Ag/l) in the form of Ag20-Mal, Ag40-Mal, Ag100-Mal, bulk Ag and aqueous Ag (as AgNO3), as well as to the concentrations of maltose used in the formulation of NPs. Mortality, bioaccumulation, tissue and cell distribution and lysosomal responses were investigated...
January 5, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28055261/sound-understanding-of-environmental-health-and-safety-clinical-and-market-aspects-is-imperative-to-clinical-translation-of-nanomedicines
#7
Matthias Rösslein, Neill Liptrott, Andrew Owen, Patrick Boisseau, Peter Wick, Inge K Herrmann
No abstract text is available yet for this article.
January 5, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28044465/in-situ-quantification-of-diverse-titanium-dioxide-nanoparticles-unveils-selective-endoplasmic-reticulum-stress-dependent-toxicity
#8
Marina Simon, Gladys Saez, Giovanna Muggiolu, Magali Lavenas, Quentin Le Trequesser, Claire Michelet, Guillaume Devès, Philippe Barberet, Eric Chevet, Denis Dupuy, Marie-Hélène Delville, Hervé Seznec
Although titanium dioxide nanoparticles (TiO2 NPs) have been extensively studied, their possible impact on health due to their specific properties supported by their size and geometry, remains to be fully characterized to support risk assessment. To further document NPs biological effects, we investigated the impact of TiO2 NPs morphology on biological outcomes. To this end, TiO2 NPs were synthesized as nanoneedles (NNs), titanate scrolled nanosheets (TNs), gel-sol-based isotropic nanoparticle (INPs) and tested for perturbation of cellular homeostasis (cellular ion content, cell proliferation, stress pathways) in three cell types and compared to the P25...
January 3, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28044458/application-of-bayesian-networks-for-hazard-ranking-of-nanomaterials-to-support-human-health-risk-assessment
#9
Hans J P Marvin, Yamine Bouzembrak, Esmée M Janssen, Meike van der Zande, Finbarr Murphy, Barry Sheehan, Martin Mullins, Hans Bouwmeester
In this study a Bayesian Network (BN) was developed for the prediction of the hazard potential and biological effects with the focus on metal- and metal-oxide nanomaterials to support human health risk assessment. The developed BN captures the (inter) relationships between the exposure route, the nanomaterials physicochemical properties, and the ultimate biological effects in a holistic manner and was based on international expert consultation and the scientific literature (e.g. in vitro/in vivo data). The BN was validated with independent data extracted from published studies and the accuracy of the prediction of the nanomaterials hazard potential was 72% and for the biological effect 71%, respectively...
January 3, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28024451/weathering-in-soil-increases-nanoparticle-cuo-bioaccumulation-within-a-terrestrial-food-chain
#10
Alia D Servin, Luca Pagano, Hiram Castillo-Michel, Roberto De la Torre-Roche, Joseph Hawthorne, Jose A Hernandez-Viezcas, René Loredo-Portales, Sanghamitra Majumdar, Jorge Gardea-Torresday, Om Parkash Dhankher, Jason C White
This study evaluates the bioaccumulation of unweathered (U) and weathered (W) CuO in NP, bulk and ionic form (0-400 mg/kg) by lettuce exposed for 70 d in soil co-contaminated with field incurred chlordane. To evaluate CuO trophic transfer, leaves were fed to crickets (Acheta domestica) for 15 d, followed by insect feeding to lizards (Anolis carolinensis). Upon weathering, the root Cu content of the NP treatment increased 214% (327 ± 59.1 mg/kg) over unaged treatment. Cu root content decreased in bulk and ionic treatments from 70-130 mg/kg to 13-26 mg/kg upon aging in soil...
December 26, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/28008795/a-comparison-of-fate-and-toxicity-of-selenite-biogenically-and-chemically-synthesized-selenium-nanoparticles-to-zebrafish-danio-rerio-embryogenesis
#11
Joyabrata Mal, Wouter J Veneman, Y V Nancharaiah, Eric D van Hullebusch, Willie J G M Peijnenburg, Martina G Vijver, Piet N L Lens
Microbial reduction of selenium (Se) oxyanions to elemental Se is a promising technology for bioremediation and treatment of Se wastewaters. But a fraction of biogenic nano-Selenium (nano-Se(b)) formed in bioreactors remains suspended in the treated waters, thus entering the aquatic environment. The present study investigated the toxicity of nano-Se(b) formed by anaerobic granular sludge biofilms on zebrafish embryos in comparison with selenite and chemogenic nano-Se (nano-Se(c)). The nano-Se(b) formed by granular sludge biofilms showed a LC50 value of 1...
December 23, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27927091/the-integrated-biomarker-response-a-suitable-tool-to-evaluate-toxicity-of-metal-based-nanoparticles
#12
Simon Devin, Pierre E Buffet, Amélie Châtel, Hanane Perrein-Ettajani, Eugénia Valsami-Jones, Catherine Mouneyrac
Nanotechnology is a much promising field of science and technology with applications in a wide range of areas such as electronics, biomedical applications, energy and cosmetics. Metal-based engineered nanoparticles (ENPs) are common in many technological applications; some of the most common nanoparticles available commercially are silver, gold, copper oxide (CuO), zinc oxide (ZnO) and cadmium sulphide (CdS). The toxicity of metal-based NPs may be either due to their specific physical characteristics as NPs or to the specific toxicity of metals released from NPs under environmental conditions...
December 21, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27901397/a-systems-toxicology-approach-reveals-the-wnt-mapk-crosstalk-pathway-mediated-reproductive-failure-in-caenorhabditis-elegans-exposed-to-graphene-oxide-go-but-not-to-reduced-graphene-oxide-rgo
#13
Nivedita Chatterjee, Youngho Kim, Jisu Yang, Carlos P Roca, Sang-Woo Joo, Jinhee Choi
The potential hazards of graphene nanomaterials were investigated by exposing the nematode Caenorhabditis elegans to graphene oxide (GO) and reduced graphene oxide (rGO). The underlying mechanisms of the nano-bio interaction were addressed with an integrated systems toxicology approach using global transcriptomics, network-based pathway analysis, and experimental validation of the in-silico-derived hypotheses. Graphene oxide was found to reduce the worms' reproductive health to a greater degree than rGO, but it did not affect survival (24 h endpoint)...
December 20, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27885867/protein-corona-modulation-of-hepatocyte-uptake-and-molecular-mechanisms-of-gold-nanoparticle-toxicity
#14
Kyoungju Choi, Jim E Riviere, Nancy A Monteiro-Riviere
Protein corona formation over gold nanoparticles (AuNP) can modulate cellular responses by altering AuNP physicochemical properties. The liver plays an essential role in metabolism, detoxification and elimination of xenobiotics and drugs as well as circulating NP clearance. We investigated human hepatic uptake of 40 and 80 nm AuNP with branched polyethylenimine (BPEI), lipoic acid (LA) and polyethylene glycol (PEG) coatings as well as human plasma protein (HP) and human serum albumin (HSA) coronas. AuNP-mediated cytotoxicity, reactive oxygen/reactive nitrogen species (ROS/RNS), and CYP activity in human hepatocytes as well as molecular mechanisms with 40 nm bare and HP BPEI-AuNP were investigated...
December 14, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27855548/markers-of-lipid-oxidative-damage-in-the-exhaled-breath-condensate-of-nano-tio2-production-workers
#15
Daniela Pelclova, Vladimir Zdimal, Petr Kacer, Nadezda Zikova, Martin Komarc, Zdenka Fenclova, Stepanka Vlckova, Jaroslav Schwarz, Otakar Makeš, Kamila Syslova, Tomas Navratil, Francesco Turci, Ingrid Corazzari, Sergey Zakharov, Dhimiter Bello
Nanoscale titanium dioxide (nanoTiO2) is a commercially important nanomaterial. Animal studies have documented lung injury and inflammation, oxidative stress, cytotoxicity and genotoxicity. Yet, human health data are scarce and quantitative risk assessments and biomonitoring of exposure are lacking. NanoTiO2 is classified by IARC as a group 2B, possible human carcinogen. In our earlier studies we documented an increase in markers of inflammation, as well as DNA and protein oxidative damage, in exhaled breath condensate (EBC) of workers exposed nanoTiO2...
December 9, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27852133/timp1-promotes-multi-walled-carbon-nanotube-induced-lung-fibrosis-by-stimulating-fibroblast-activation-and-proliferation
#16
Jie Dong, Qiang Ma
Pulmonary exposure to multi-walled carbon nanotubes (MWCNTs) may cause fibrosing lesions in animal lungs, raising health concerns about such exposure in humans. The mechanisms underlying fibrosis development remain unclear, but they are believed to involve the dysfunction of fibroblasts and myofibroblasts. Using a mouse model of MWCNT exposure, we found that the tissue inhibitor of metalloproteinase 1 (Timp1) gene was rapidly and highly induced in the lungs by MWCNTs in a time- and dose-dependent manner. Concomitantly, a pronounced elevation of secreted TIMP1 was observed in the bronchoalveolar lavage (BAL) fluid and serum...
December 9, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27855561/frozen-dispersions-of-nanomaterials-are-a-useful-operational-procedure-in-nanotoxicology
#17
Laura Vila, Laura Rubio, Balasubramanyam Annangi, Alba García-Rodríguez, Ricard Marcos, Alba Hernández
The variability observed in nanoparticle (NP) dispersions can affect the reliability of the results obtained in short-term tests, and mainly in long-term experiments. In addition, obtaining a good dispersion is time-consuming and acts as a bottleneck in the development of high-throughput screening methodologies. The freezing of different aliquots from a stock dispersion would overcome such limitations, but no studies have explored the impact of freezing thawing the samples on the physico-chemical and biological properties of the nanomaterial (NM)...
December 1, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27894206/occupational-exposure-limits-for-manufactured-nanomaterials-a-systematic-review
#18
Raluca Mihalache, Jos Verbeek, Halshka Graczyk, Vladimir Murashov, Pieter van Broekhuizen
BACKGROUND: The toxicological properties of manufactured nanomaterials (MNMs) can be different from their bulk-material and uncertainty remains about the adverse health effects they may have on humans. Proposals for OELs have been put forward which can be useful for risk management and workers' protection. We performed a systematic review of proposals for OELs for MNMs to better understand the extent of such proposals, as well as their derivation methods. METHODS: We searched PubMed and Embase with an extensive search string and also assessed the references in the included studies...
November 29, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27809641/modeling-uptake-of-nanoparticles-in-multiple-human-cells-using-structure-activity-relationships-and-intercellular-uptake-correlations
#19
Nikita Basant, Shikha Gupta
Biomedical applications of nanoparticles (NPs) are largely dependent on their cellular uptake potential that enables them to reach the specific targets in the body. Experimental determination of cellular uptake of diverse functionalized NPs in different human cell types is tedious, expensive and time intensive, hence compelling for alternative methods. We developed QSAR models for predicting uptake of functionalized NPs in multiple cell types in accordance with the OECD guidelines. The decision treeboost QSAR models precisely predicted uptake of 104 NPs in five different cell types yielding high R(2) between experimental and model predicted values in the respective training (>0...
November 4, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27781563/are-engineered-nano-iron-oxide-particles-safe-an-environmental-risk-assessment-by-probabilistic-exposure-effects-and-risk-modeling
#20
Yan Wang, Lei Deng, Alejandro Caballero-Guzman, Bernd Nowack
Nano iron oxide particles are beneficial to our daily lives through their use in paints, construction materials, biomedical imaging and other industrial fields. However, little is known about the possible risks associated with the current exposure level of engineered nano iron oxides (nano-FeOX) to organisms in the environment. The goal of this study was to predict the release of nano-FeOX to the environment and assess their risks for surface waters in the EU and Switzerland. The material flows of nano-FeOX to technical compartments (waste incineration and waste water treatment plants) and to the environment were calculated with a probabilistic modeling approach...
December 2016: Nanotoxicology
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