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Nanotoxicology

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https://www.readbyqxmd.com/read/28741972/the-effect-of-zirconium-doping-of-cerium-dioxide-nanoparticles-on-pulmonary-and-cardiovascular-toxicity-and-biodistribution-in-mice-after-inhalation
#1
Susan Dekkers, Mark R Miller, Roel P F Schins, Isabella Römer, Mike Russ, Rob J Vandebriel, Iseult Lynch, Marie-France Belinga-Desaunay, Eugenia Valsami-Jones, Shea P Connell, Ian P Smith, Rodger Duffin, John A F Boere, Harm J Heusinkveld, Catrin Albrecht, Wim H de Jong, Flemming R Cassee
Development and manufacture of nanomaterials is growing at an exponential rate, despite an incomplete understanding of how their physicochemical characteristics affect their potential toxicity. Redox activity has been suggested to be an important physicochemical property of nanomaterials to predict their biological activity. This study assessed the influence of redox activity by modification of cerium dioxide nanoparticles (CeO2 NPs) via zirconium (Zr) doping on the biodistribution, pulmonary and cardiovascular effects in mice following inhalation...
July 25, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28671030/continuous-in-vitro-exposure-of-intestinal-epithelial-cells-to-e171-food-additive-causes-oxidative-stress-inducing-oxidation-of-dna-bases-but-no-endoplasmic-reticulum-stress
#2
Marie Dorier, David Béal, Caroline Marie-Desvergne, Muriel Dubosson, Frédérick Barreau, Eric Houdeau, Nathalie Herlin-Boime, Marie Carriere
The whitening and opacifying properties of titanium dioxide (TiO2) are commonly exploited when it is used as a food additive (E171). However, the safety of this additive can be questioned as TiO2 nanoparticles (TiO2-NPs) have been classed at potentially toxic. This study aimed to shed some light on the mechanisms behind the potential toxicity of E171 on epithelial intestinal cells, using two in vitro models: (i) a monoculture of differentiated Caco-2 cells and (ii) a coculture of Caco-2 with HT29-MTX mucus-secreting cells...
July 19, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28714804/cellular-proliferation-and-differentiation-induced-by-single-layer-molybdenum-disulfide-and-mediation-mechanisms-of-proteins-via-the-akt-mtor-p70s6k-signaling-pathway
#3
Wei Zou, Xingli Zhang, Mengyang Zhao, Qixing Zhou, Xiangang Hu
Single-layer molybdenum disulfide (SLMoS2) is a novel kind of 2D nanosheet that has attracted great attention regarding its use in biosensors, drug delivery, tissue engineering and therapy. However, our results demonstrated that SLMoS2 accelerated proliferation and promoted myogenic differentiation and epithelial-mesenchymal transition (EMT) in human embryonic lung fibroblasts (HELFs). The abnormal proliferation and differentiation of HELFs contribute to idiopathic pulmonary fibrosis. Specifically, SLMoS2 significantly stimulated the expression of myofibroblast- and mesenchymal-associated genes and proteins...
July 17, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28707555/long-term-effects-of-silver-nanoparticles-in-caco-2-cells
#4
Laura Vila, Ricard Marcos, Alba Hernández
The high success of silver nanoparticles (AgNPs), mainly associated with their proved antimicrobial properties, has led to an increasing spread in our close environment. Although many studies have been carried out to detect potential toxicity of AgNPs, most of them have been developed under unrealistic exposure conditions. In terms of human risk, the evaluation of long-term exposures to sub-toxic doses of NPs remains a challenge. Here we have determined different transformation-related end-points under a scenario of 6 weeks long-term exposure to low non-cytotoxic AgNPs concentrations (0...
July 14, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28685628/bacteriomimetic-poly-%C3%AE-glutamic-acid-surface-coating-for-hemocompatibility-and-safety-of-nanomaterials
#5
Gayong Shim, Dongyoon Kim, Jinyoung Kim, Min Sung Suh, Youn Kyu Kim, Yu-Kyoung Oh
Poly-γ-glutamic acid (PGA), a major component of the bacterial capsule, is known to confer hydrophilicity to bacterial surfaces and protect bacteria from interactions with blood cells. We tested whether applying a bacteriomimetic surface coating of PGA modulates interactions of nanomaterials with blood cells or affects their safety and photothermal antitumor efficacy. Amphiphilic PGA (APGA), prepared by grafting phenylalanine residues to PGA, was used to anchor PGA to reduced graphene oxide (rGO) nanosheets, a model of hydrophobic nanomaterials...
July 7, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28627335/effects-of-exposure-pathways-on-the-accumulation-and-phytotoxicity-of-silver-nanoparticles-in-soybean-and-rice
#6
Cheng-Cheng Li, Fei Dang, Min Li, Min Zhu, Huan Zhong, Holger Hintelmann, Dong-Mei Zhou
The widespread use of silver nanoparticles (AgNPs) raises concerns both about their accumulation in crops and human exposure via crop consumption. Plants take up AgNPs through their leaves and roots, but foliar uptake has been largely ignored. To better understand AgNPs-plant interactions, we compared the uptake, phytotoxicity and size distribution of AgNPs in soybean and rice following root versus foliar exposure. At similar AgNP application levels, foliar exposure led to 17-200 times more Ag bioaccumulation than root exposure...
July 7, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28618895/silver-nanoparticles-inhaled-during-pregnancy-reach-and-affect-the-placenta-and-the-foetus
#7
Luisa Campagnolo, Micol Massimiani, Lucia Vecchione, Diletta Piccirilli, Nicola Toschi, Andrea Magrini, Elena Bonanno, Manuel Scimeca, Luca Castagnozzi, Giorgio Buonanno, Luca Stabile, Francesco Cubadda, Federica Aureli, Paul Hb Fokkens, Wolfgang G Kreyling, Flemming R Cassee, Antonio Pietroiusti
Recently, interest for the potential impact of consumer-relevant engineered nanoparticles on pregnancy has dramatically increased. This study investigates whether inhaled silver nanoparticles (AgNPs) reach and cross mouse placental barrier and induce adverse effects. Apart from their relevance for the growing use in consumer products and biomedical applications, AgNPs are selected since they can be unequivocally identified in tissues. Pregnant mouse females are exposed during the first 15 days of gestation by nose-only inhalation to a freshly produced aerosol of 18-20 nm AgNPs for either 1 or 4 h, at a particle number concentration of 3...
July 7, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28673184/toxicogenomics-of-iron-oxide-nanoparticles-in-the-nematode-c-elegans
#8
Laura Gonzalez-Moragas, Si-Ming Yu, Núria Benseny-Cases, Stephen Stürzenbaum, Anna Roig, Anna Laromaine
We present a mechanistic study of the effect of iron oxide nanoparticles (SPIONs) in Caenorhabditis elegans combining a genome-wide analysis with the investigation of specific molecular markers frequently linked to nanotoxicity. The effects of two different coatings were explored: citrate, an anionic stabilizer, and bovine serum albumin, as a pre-formed protein corona. The transcriptomic study identified differentially expressed genes following an exposure to SPIONs. The expression of genes involved in oxidative stress, metal detoxification response, endocytosis, intestinal integrity and iron homeostasis was quantitatively evaluated...
July 4, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28669258/titanium-dioxide-nanoparticles-prime-a-specific-activation-state-of-macrophages
#9
Chao Huang, Mayu Sun, Yang Yang, Feng Wang, Xueqi Ma, Jingquan Li, Yilong Wang, Qiurong Ding, Hao Ying, Haiyun Song, Yongning Wu, Yiguo Jiang, Xudong Jia, Qian Ba, Hui Wang
Titanium dioxide nanoparticles (TiO2 NPs) are widely used in foods, cosmetics, and medicine. Although the inhalation toxicity of TiO2 NPs has been studied, the potential adverse effects of oral exposure of low-dose TiO2 NPs are largely unclear. Herein, with macrophage cell lines, primary cells, and mouse models, we show that TiO2 NPs prime macrophages into a specific activation state characterized by excessive inflammation and suppressed innate immune function. After a month of dietary exposure in mice or exposure in vitro to TiO2 NPs (10 nm and 50 nm), the expressions of pro-inflammatory genes in macrophages were increased, and the expressions of anti-inflammatory genes were decreased...
July 3, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28660804/evaluation-of-the-molecular-mechanisms-associated-with-cytotoxicity-and-inflammation-after-pulmonary-exposure-to-different-metal-rich-welding-particles
#10
Mohammad Shoeb, Vamsi Kodali, Breanne Farris, Lindsey M Bishop, Terence Meighan, Rebecca Salmen, Tracy Eye, Jenny R Roberts, Patti Zeidler-Erdely, Aaron Erdely, James M Antonini
Welding generates a complex aerosol of incidental nanoparticles and cytotoxic metals, such as chromium (Cr), manganese (Mn), nickel (Ni), and iron (Fe). The goal was to use both in vivo and in vitro methodologies to determine the mechanisms by which different welding fumes may damage the lungs. Sprague-Dawley rats were treated by intratracheal instillation (ITI) with 2.0 mg of gas metal arc-mild steel (GMA-MS) or manual metal arc-stainless steel (MMA-SS) fumes or saline (vehicle control). At 1, 3, and 10 days, bronchoalveolar lavage (BAL) was performed to measure lung toxicity...
June 29, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28627273/nanoparticle-interactions-with-co-existing-contaminants-joint-toxicity-bioaccumulation-and-risk
#11
Rui Deng, Daohui Lin, Lizhong Zhu, Sanghamitra Majumdar, Jason C White, Jorge L Gardea-Torresdey, Baoshan Xing
With their growing production and application, engineered nanoparticles (NPs) are increasingly discharged into the environment. The released NPs can potentially interact with pre-existing contaminants, leading to biological effects (bioaccumulation and/or toxicity) that are poorly understood. Most studies on NPs focus on single analyte exposure; the existing literature on joint toxicity of NPs and co-existing contaminants is rather limited but beginning to develop rapidly. This is the first review paper evaluating the current state of knowledge regarding the joint effects of NPs and co-contaminants...
June 19, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28617070/oral-subchronic-exposure-to-silver-nanoparticles-causes-renal-damage-through-apoptotic-impairment-and-necrotic-cell-death
#12
Ratnakar Tiwari, Radha Dutt Singh, Hafizurrahman Khan, Siddhartha Gangopadhyay, Sandeep Mittal, Vikas Singh, Nidhi Arjaria, Jai Shankar, Somendu Kumar Roy, Dhirendra Singh, Vikas Srivastava
Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials. Following oral exposure, AgNPs can accumulate in various organs including kidneys where they show gender specific accumulation. There is limited information on their effect on renal system following long-term animal exposure especially at the ultramicroscopic and molecular level. In this study, we have assessed the effect of 60 days oral AgNPs treatment on kidneys of female Wistar rats at doses of 50 ppm and 200 ppm that are below previously reported lowest observed adverse effect level (LOAEL)...
June 15, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28608745/time-resolved-toxicity-study-reveals-the-dynamic-interactions-between-uncoated-silver-nanoparticles-and-bacteria
#13
Feng Dong, Nurul Fitriah Mohd Zaidi, Eugenia Valsami-Jones, Jan-Ulrich Kreft
It is still unclear whether the toxicity of silver nanoparticles (AgNPs) can be attributed solely to the release of Ag(+) or whether dissolved and nanoparticulate Ag act in parallel; this is due to the difficulty in distinguishing Ag(+)- from AgNP-effects. Also, AgNPs undergo changes during toxicity tests. This is the first study to investigate the influence of AgNP dissolution over time on viable counts at high time resolution and low cell density, avoiding the apparently reduced toxicity at higher cell densities identified in our study...
June 13, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28594294/ceo2-nanoparticles-alter-the-outcome-of-species-interactions
#14
Cheng Peng, Ying Chen, Zhichao Pu, Qing Zhao, Xin Tong, Yongsheng Chen, Lin Jiang
Despite considerable research on the environmental impacts of nanomaterials, we know little about how they influence interactions between species. Here, we investigated the acute (12 d) and chronic (64 d) toxicities of cerium oxide nanoparticles (CeO2 NPs) and bulk particles (0 ∼ 200 mg/L) to three ciliated protist species (Loxocephalus sp., Paramecium aurelia, and Tetrahymena pyriformis) in single-, bi-, and multispecies microcosms. The results show that CeO2 NPs strongly affected the interactions between ciliated protozoan species...
June 8, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28513319/effect-of-surface-functionalizations-of-multi-walled-carbon-nanotubes-on-neoplastic-transformation-potential-in-primary-human-lung-epithelial-cells
#15
Todd A Stueckle, Donna C Davidson, Ray Derk, Peng Wang, Sherri Friend, Diane Schwegler-Berry, Peng Zheng, Nianqiang Wu, Vince Castranova, Yon Rojanasakul, Liying Wang
Functionalized multi-walled carbon nanotube (fMWCNT) development has been intensified to improve their surface activity for numerous applications, and potentially reduce toxic effects. Although MWCNT exposures are associated with lung tumorigenesis in vivo, adverse responses associated with exposure to different fMWCNTs in human lung epithelium are presently unknown. This study hypothesized that different plasma-coating functional groups determine MWCNT neoplastic transformation potential. Using our established model, human primary small airway epithelial cells (pSAECs) were continuously exposed for 8 and 12 weeks at 0...
June 2, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28503974/biokinetics-of-engineered-nano-tio2-in-rats-administered-by-different-exposure-routes-implications-for-human-health
#16
Dhimiter Bello, David B Warheit
No abstract text is available yet for this article.
May 19, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28490217/antimicrobial-proteins-in-the-response-to-graphene-oxide-in-caenorhabditis-elegans
#17
Mingxia Ren, Li Zhao, Xiao Lv, Dayong Wang
Upon exposure to environmental engineered nanomaterials (ENMs), animals will activate certain response signals to protect themselves from the toxic effects. However, the underlying molecular mechanisms for this response are still largely unclear. Using in vivo assay system of Caenorhabditis elegans, we here found that antimicrobial proteins of LYS-1, LYS-8, SPP-1, DOD-6, and F55G11.4 were activated by graphene oxide (GO) exposure. These antimicrobial proteins functioned as molecular targets of transcriptional factor DAF-16 in insulin signaling pathway, and acted in intestine to regulate the response to GO...
May 19, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28490213/are-fluorescence-based-chlorophyll-quantification-methods-suitable-for-algae-toxicity-assessment-of-carbon-nanomaterials
#18
Julia Farkas, Andy M Booth
Using a multiwalled carbon nanotube (MWCNT) and graphene oxide (GO) as representative test materials, we evaluated the applicability of in vivo and in vitro chlorophyll-a (Chl-a) fluorescence quantification methods, which are used in standard algae ecotoxicity tests such as OECD 201 and ISO 8692. In vivo quantification of Chl-a from Raphidocelis subcapitata indicated a significant reduction in Chl-a fluorescence in the presence of MWCNTs due to shading, but a significant autofluorescence from GO caused an overestimation of Chl-a concentration...
May 19, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28494628/probabilistic-risk-assessment-of-emerging-materials-case-study-of-titanium-dioxide-nanoparticles
#19
Michael P Tsang, Danail Hristozov, Alex Zabeo, Antti Joonas Koivisto, Alexander Christian Østerskov Jensen, Keld Alstrup Jensen, Chengfang Pang, Antonio Marcomini, Guido Sonnemann
The development and use of emerging technologies such as nanomaterials can provide both benefits and risks to society. Emerging materials may promise to bring many technological advantages but may not be well-characterized in terms of their production volumes, magnitude of emissions, behavior in the environment and effects on living organisms. This uncertainty can present challenges to scientists developing these materials and persons responsible for defining and measuring their adverse impacts. Human health risk assessment is a method of identifying the intrinsic hazard of and quantifying the dose-response relationship and exposure to a chemical, to finally determine the estimation of risk...
May 12, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28463032/assessing-nanomaterial-exposures-in-aquatic-ecotoxicological-testing-framework-and-case-studies-based-on-dispersion-and-dissolution
#20
Alan J Kennedy, Jessica G Coleman, Stephen A Diamond, Nicolas L Melby, Anthony J Bednar, Ashley Harmon, Zachary A Collier, Robert Moser
The unique behavior of engineered nanomaterials (ENM) in aqueous media and dynamic changes in particle settling, agglomeration and dissolution rates is a challenge to the consistency, reliability and interpretation of standard aquatic hazard bioassay results. While the toxicological endpoints (e.g., survival, growth, reproduction, etc.) in ecotoxicity bioassays are largely applicable to ENMs, the standard methods as written for dissolved substances are confounded by the dynamic settling, agglomeration and dissolution of particulate ENMs during the bioassay...
May 2, 2017: Nanotoxicology
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