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Nanotoxicology

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https://www.readbyqxmd.com/read/29338488/macrophage-polarization-and-activation-at-the-interface-of-multi-walled-carbon-nanotube-induced-pulmonary-inflammation-and-fibrosis
#1
Jie Dong, Qiang Ma
Pulmonary exposure to carbon nanotubes (CNTs) induces fibrosing lesions in the lungs that manifest rapid-onset inflammatory and fibrotic responses, leading to chronic fibrosis in animals and health concerns in exposed humans. The mechanisms underlying CNT-induced fibrogenic effects remain undefined. Macrophages are known to play important roles in immune regulation and fibrosis development through their distinct subsets. Here we investigated macrophage polarization and activation in mouse lungs exposed to multi-walled CNTs (MWCNTs)...
January 16, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29338479/graphene-oxide-regulates-cox2-in-human-embryonic-kidney-293t-cells-via-epigenetic-mechanisms-dynamic-chromosomal-interactions
#2
Yuxiang Sun, Hui Dai, Shaopeng Chen, Ming Xu, Xuanyu Wang, Yajun Zhang, Shengmin Xu, An Xu, Jian Weng, Sijin Liu, Lijun Wu
To extend the applications of engineered nanomaterials, such as graphene oxide (GO), it is necessary to minimize cytotoxicity. However, the mechanisms underlying this cytotoxicity are unclear. Dynamic chromosomal interactions have been used to illustrate the molecular bases of gene expression, which offers a more sensitive and cutting-edge technology to elucidate complex biological processes associated with epigenetic regulations. In this study, the role of GO-triggered chromatin interactions in the activation of cox2, a hallmark of inflammation, was investigated in normal human cells...
January 16, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29338468/inhibition-of-the-proteasome-activity-by-graphene-oxide-contributes-to-its-cytotoxicity
#3
Xiaochuan Ma, Sangyun Lee, Xingshu Fei, Ge Fang, Tien Huynh, Yu Chong, Zhifang Chai, Cuicui Ge, Ruhong Zhou
Due to its hydrophobicity and other unique physicochemical properties, graphene oxide (GO) has been extensively utilized in various biological applications. However, introducing nanomaterials into the biological environment may raise serious risk in terms of nanotoxicity, leading to some unintended changes to the structure and the function of other biomolecules. This study investigates the interaction of GO with the ubiquitin-proteasome system, one of the essential machineries in the cellular metabolism, using a combination of experimental and computational approaches...
January 16, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29334833/silver-nanoparticles-induce-neurotoxicity-in-a-human-embryonic-stem-cell-derived-neuron-and-astrocyte-network
#4
Neza Repar, Hao Li, Jose S Aguilar, Qingshun Quinn Li, Damjana Drobne, Yiling Hong
Silver nanoparticles (AgNPs) are among the most extensively used nanoparticles and are found in a variety of products. This ubiquity leads to inevitable exposure to these particles in everyday life. However, the effects of AgNPs on neuron and astrocyte networks are still largely unknown. In this study, we used neurons and astrocytes derived from human embryonic stem cells as a cellular model to study the neurotoxicity that is induced by citrate-coated AgNPs (AgSCs). Immunostaining with the astrocyte and neuron markers, glial fibrillary acidic protein and microtubule-associated protein-2 (MAP2), respectively, showed that exposure to AgSCs at the concentration of 0...
January 15, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29334310/dendritic-polyglycerol-nanoparticles-show-charge-dependent-bio-distribution-in-early-human-placental-explants-and-reduce-hcg-secretion
#5
Herbert Juch, Liudmila Nikitina, Sabine Reimann, Martin Gauster, Gottfried Dohr, Barbara Obermayer-Pietsch, Denise Hoch, Karin Kornmueller, Rainer Haag
A thorough understanding of nanoparticle bio-distribution at the feto-maternal interface will be a prerequisite for their diagnostic or therapeutic application in women of childbearing age and for teratologic risk assessment. Therefore, the tissue interaction of biocompatible dendritic polyglycerol nanoparticles (dPG-NPs) with first- trimester human placental explants were analyzed and compared to less sophisticated trophoblast-cell based models. First-trimester human placental explants, BeWo cells and primary trophoblast cells from human term placenta were exposed to fluorescence labeled, ∼5 nm dPG-NPs, with differently charged surfaces, at concentrations of 1 µM and 10 nM, for 6 and 24 h...
January 15, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29334298/long-term-effects-of-tungsten-carbide-wc-nanoparticles-in-pelagic-and-benthic-aquatic-ecosystems
#6
Mikael T Ekvall, Jonas Hedberg, Inger Odnevall Wallinder, Lars-Anders Hansson, Tommy Cedervall
As the production and usage of nanomaterials are increasing so are the concerns related to the release of the material into nature. Tungsten carbide (WC) is widely used for its hard metal properties, although its use, in for instance tyre studs, may result in nano-sized particles ending up in nature. Here, we evaluate the potential long-term exposure effects of WC nanoparticles on a pelagic (Daphnia magna) and a benthic (Asellus aquaticus) organism. No long-term effects were observed in the benthic system with respect to population dynamics or ecosystem services...
January 15, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29324056/cardiopulmonary-effects-induced-by-occupational-exposure-to-titanium-dioxide-nanoparticles
#7
Lin Zhao, Yifang Zhu, Zhangjian Chen, Huadong Xu, Jingwen Zhou, Shichuan Tang, Zhizhen Xu, Fanling Kong, Xinwei Li, Yifei Zhang, Xianzuo Li, Ji Zhang, Guang Jia
Although some toxicological studies have reported that exposure to titanium dioxide nanoparticles (nano-TiO2) may elicit adverse cardiopulmonary effects, related data collected from human are currently limited. The purpose of this study is to explore cardiopulmonary effects among workers who were exposed to nano-TiO2 and to identify biomarkers associated with exposure. A cross-sectional study was conducted in a nano-TiO2 manufacturing plant in eastern China. Exposure assessment and characterization of TiO2 particles were performed in a packaging workshop...
January 11, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29262761/dissolution-and-bandgap-paradigms-for-predicting-the-toxicity-of-metal-oxide-nanoparticles-in-the-marine-environment-an-in-vivo-study-with-oyster-embryos
#8
Seta Noventa, Christian Hacker, Darren Rowe, Christine Elgy, Tamara Galloway
Dissolution and bandgap paradigms have been proposed for predicting the ability of metal oxide nanoparticles (NPs) to induce oxidative stress in different in vitro and in vivo models. Here, we addressed the effectiveness of these paradigms in vivo and under conditions typical of the marine environment, a final sink for many NPs released through aquatic systems. We used ZnO and MnO2 NPs as models for dissolution and bandgap paradigms, respectively, and CeO2 NPs to assess reactive oxygen radical (ROS) production via Fenton-like reactions in vivo...
December 20, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29261040/fluorescent-nanoparticles-present-in-coca-cola-and-pepsi-cola-physiochemical-properties-cytotoxicity-biodistribution-and-digestion-studies
#9
Shen Li, Chengkun Jiang, Haitao Wang, Shuang Cong, Mingqian Tan
Foodborne nanoparticles (NPs) have drawn great attention due to human health concerns. This study reports the detection of the presence of fluorescent NPs, about 5 nm, in two of the most popular beverages, Coca-Cola (Coke) and Pepsi-Cola (Pepsi). The NPs contain H, C and O, three elements with a tunable emission and with a quantum yield of 3.3 and 4.3% for Coke and Pepsi, respectively. The presence of sp3-hybridized carbon atoms of alcohols and ethers bonds was confirmed by NMR analysis. The NPs can be taken up by living cells and accumulate within cell membrane and cytoplasm...
December 20, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29251527/decision-tree-models-to-classify-nanomaterials-according-to-the-df4nanogrouping-scheme
#10
Agnieszka Gajewicz, Tomasz Puzyn, Katarzyna Odziomek, Piotr Urbaszek, Andrea Haase, Christian Riebeling, Andreas Luch, Muhammad A Irfan, Robert Landsiedel, Meike van der Zande, Hans Bouwmeester
To keep pace with its rapid development an efficient approach for the risk assessment of nanomaterials is needed. Grouping concepts as developed for chemicals are now being explored for its applicability to nanomaterials. One of the recently proposed grouping systems is DF4nanoGrouping scheme. In this study, we have developed three structure-activity relationship classification tree models to be used for supporting this system by identifying structural features of nanomaterials mainly responsible for the surface activity...
December 18, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29251223/research-on-the-hepatotoxicity-mechanism-of-citrate-modified-silver-nanoparticles-based-on-metabolomics-and-proteomics
#11
Jiabin Xie, Wenying Dong, Rui Liu, Yuming Wang, Yubo Li
Citrate-modified silver nanoparticles (AgNP-cit) have received extensive attention due to their excellent antimicrobial properties. However, these particles tend to migrate in vivo, thereby entering the blood circulatory system in granular form and accumulating in the liver, causing toxic reactions. However, the mechanism underlying AgNP-cit toxicity is not yet clear. Thus, we adopted a tandem mass tag (TMT)-labeled quantitative proteomics and metabolomics approach to identify proteins and small molecule metabolites associated with AgNP-cit-induced liver damage and constructed interaction networks between the differentially expressed proteins and metabolites to explain the AgNP-cit toxicity mechanism...
December 18, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29243970/reactive-oxygen-species-damage-drives-cardiac-and-mitochondrial-dysfunction-following-acute-nano-titanium-dioxide-inhalation-exposure
#12
Cody E Nichols, Danielle L Shepherd, Quincy A Hathaway, Andrya J Durr, Dharendra Thapa, Alaeddin Abukabda, Jinghai Yi, Timothy R Nurkiewicz, John M Hollander
Nanotechnology offers innovation in products from cosmetics to drug delivery, leading to increased engineered nanomaterial (ENM) exposure. Unfortunately, health impacts of ENM are not fully realized. Titanium dioxide (TiO2) is among the most widely produced ENM due to its use in numerous applications. Extrapulmonary effects following pulmonary exposure have been identified and may involve reactive oxygen species (ROS). The goal of this study was to determine the extent of ROS involvement on cardiac function and the mitochondrion following nano-TiO2 exposure...
December 15, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29192556/bacterial-endotoxin-lipopolysaccharide-binds-to-the-surface-of-gold-nanoparticles-interferes-with-biocorona-formation-and-induces-human-monocyte-inflammatory-activation
#13
Yang Li, Zhenzhen Shi, Isabella Radauer-Preiml, Ancuela Andosch, Eudald Casals, Ursula Luetz-Meindl, Macarena Cobaleda, Zhoumeng Lin, Majid Jaberi-Douraki, Paola Italiani, Jutta Horejs-Hoeck, Martin Himly, Nancy A Monteiro-Riviere, Albert Duschl, Victor F Puntes, Diana Boraschi
Nanoparticles (NPs) are easily contaminated by bacterial endotoxin (lipopolysaccharide [LPS]). The presence of LPS can be responsible for many immune/inflammatory effects attributed to NPs. In this study, we examined the effects of LPS adsorption on the NP surface on the formation of a biocorona in biological fluids and on the subsequent inflammation-inducing activity of NPs. Different gold (Au) NPs with sizes ranging from 10 to 80 nm and with different surface functionalization (sodium citrate, lipoic acid, and branched polyethyleneimine (BPEI), or polyethylene glycol (PEG)) were exposed to E...
December 1, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29192531/comparison-of-acute-to-chronic-ratios-between-silver-and-gold-nanoparticles-using-ceriodaphnia-dubia
#14
Ashley R Harmon, Alan J Kennedy, Jennifer G Laird, Anthony J Bednar, Jeffery A Steevens
As integration of nanoparticles (NPs) into products becomes more common, the need to address the paucity of chronic hazard information for aquatic environments required to determine risk potential increases. This study generated acute and chronic toxicity reference values for Ceriodaphnia dubia exposed to 20 and 100 nm silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) to generate and evaluate potential differences in acute-to-chronic ratios (ACR) using two different feeding methods. A modified feeding procedure was employed alongside the standard procedures to investigate the influence of food on organism exposure...
December 1, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29191063/changes-in-dna-methylation-induced-by-multi-walled-carbon-nanotube-exposure-in-the-workplace
#15
Manosij Ghosh, Deniz Öner, Katrien Poels, Ali M Tabish, Jelle Vlaanderen, Anjoeka Pronk, Eelco Kuijpers, Qing Lan, Roel Vermeulen, Bram Bekaert, Peter Hm Hoet, Lode Godderis
This study was designed to assess the epigenetic alterations in blood cells, induced by occupational exposure to multi-wall carbon nanotubes (MWCNT). The study population comprised of MWCNT-exposed workers (n=24) and unexposed controls (n=43) from the same workplace. We measured global DNA methylation/hydroxymethylation levels on the 5th cytosine residues using a validated liquid chromatography tandem-mass spectrometry (LC-MS/MS) method. Sequence-specific methylation of LINE1 retrotransposable element 1 (L1RE1) elements, and promoter regions of functionally important genes associated with epigenetic regulation [DNA methyltransferase-1 (DNMT1) and histone deacetylase 4 (HDAC4)], DNA damage/repair and cell cycle pathways [nuclear protein, coactivator of histone transcription/ATM serine/threonine kinase (NPAT/ATM)], and a potential transforming growth factor beta (TGF-β) repressor [SKI proto-oncogene (SKI)] were studied using bisulfite pyrosequencing...
November 30, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29183205/the-elemental-changes-occurring-in-the-rat-liver-after-exposure-to-peg-coated-iron-oxide-nanoparticles-total-reflection-x-ray-fluorescence-txrf-spectroscopy-study
#16
Katarzyna Matusiak, Agnieszka Skoczen, Zuzanna Setkowicz, Aldona Kubala-Kukus, Ilona Stabrawa, Małgorzata Ciarach, Krzysztof Janeczko, Aleksandra Jung, Joanna Chwiej
The main goal of this study was to evaluate in vivo effects of low dose of PEG-coated magnetic iron oxide nanoparticles (IONPs) on the rat liver. The IONPs was intravenously injected into rats at a dose equaled to 0.03 mg of Fe per 1 kg of an animal body weight. The elemental composition of liver tissue in rats subjected to IONPs action and controls were compared. Moreover, in order to determine the dynamics of nanoparticles (NPs) induced elemental changes, the tissues taken from animals 2 hours, 24 hours, and 7 days from IONPs injection were examined...
November 29, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29172839/assessment-of-evidence-for-nanosized-titanium-dioxide-generated-dna-strand-breaks-and-oxidatively-damaged-dna-in-cells-and-animal-models
#17
Peter Møller, Ditte Marie Jensen, Regitze Sølling Wils, Maria Helena Guerra Andersen, Pernille Høgh Danielsen, Martin Roursgaard
Nanosized titanium dioxide (TiO2) has been investigated in numerous studies on genotoxicity, including comet assay endpoints and oxidatively damaged DNA in cell cultures and animal models. The results have been surprisingly mixed, which might be attributed to physico-chemical differences of the tested TiO2. In the present review, we assess the role of certain methodological issues and publication bias. The analysis shows that studies on DNA strand breaks without proper assay controls or very low intra-group variation tend to show statistically significant effects...
November 27, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29172825/metal-load-assessment-in-patient-pulmonary-lavages-towards-a-comprehensive-mineralogical-analysis-including-the-nano-sized-fraction
#18
Valérie Forest, Jean-Michel Vergnon, Cyril Guibert, Dimitrios Bitounis, Lara Leclerc, Gwendoline Sarry, Jérémie Pourchez
Mineralogical analyses of clinical samples have been proved useful to identify causal relationship between exposure to airborne particles and pulmonary diseases. The most striking example is asbestosis where the assessment of asbestos bodies in patient lung samples has allowed defining values specific of pathologies. However, this type of analyses only considers the micro-sized fraction of the particles, neglecting the specific impact of nano-sized particles which have been otherwise shown to be reactive and able to induce biological effects...
November 25, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29164963/amorphous-silica-nanoparticles-induce-malignant-transformation-and-tumorigenesis-of-human-lung-epithelial-cells-via-p53-signaling
#19
Caixia Guo, Ji Wang, Man Yang, Yang Li, Shuxiang Cui, Xianqing Zhou, Yanbo Li, Zhiwei Sun
Rapid development and deployment of engineered nanomaterials, such as amorphous silica nanoparticles (SiNPs) in various commercial and biomedical applications have raised concerns about their potential adverse health effects, especially their chronic effects which have not been well addressed. In this study, human lung epithelial cells, BEAS-2B were continuously exposed to amorphous SiNPs, 5 μg/mL for 40 passages. We demonstrated here that prolonged exposure of BEAS-2B cells to amorphous SiNPs induced malignant transformation as indicated by enhanced cellular proliferation, anchorage-independent cell growth, and increased cell migration...
November 22, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29160733/potential-impact-of-inorganic-nanoparticles-on-macronutrient-digestion-titanium-dioxide-nanoparticles-slightly-reduce-lipid-digestion-under-simulated-gastrointestinal-conditions
#20
Qian Li, Ti Li, Chengmei Liu, Glen DeLoid, Georgios Pyrgiotakis, Philip Demokritou, Ruojie Zhang, Hang Xiao, David Julian McClements
Titanium dioxide (TiO2) particles are used in some food products to alter their optical properties, such as whiteness or brightness. These additives typically contain a population of TiO2 nanoparticles (d < 100 nm), which has led to concern about their potential toxicity. The objective of this study was to examine the impact of TiO2 particles on the gastrointestinal fate of oil-in-water emulsions using a simulated gastrointestinal tract (GIT) that includes mouth, stomach, and small intestine phases...
November 21, 2017: Nanotoxicology
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