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Renata Rank Miranda, Vladimir Gorshkov, Barbara Korzeniowska, Stefan J Kempf, Francisco Filipak Neto, Frank Kjeldsen
Although multiple studies have reported the toxicological effects and underlying mechanisms of toxicity of silver nanoparticles (AgNP) in a variety of organisms, the interactions of AgNP with environmental contaminants such as cadmium are poorly understood. We used biochemical assays and mass spectrometry-based proteomics to assess the cellular and molecular effects induced by a co-exposure of HepG2 cells to AgNP and cadmium. Cell viability and energy homeostasis were slightly affected after a 4-h exposure to AgNP, cadmium, or a combination of the two; these endpoints were substantially altered after a 24-h co-exposure to AgNP and cadmium, while exposure to one of the two contaminants led only to minor changes...
July 11, 2018: Nanotoxicology
Seta Noventa, Christian Hacker, Ana Correia, Claudia Drago, Tamara Galloway
The biological fate of nanoparticles (NPs) taken up by organisms from their environment is a crucial issue for assessing ecological hazard. Despite its importance, it has scarcely been addressed due to the technical difficulties of doing so in whole organism in vivo studies. Here, by using transmission electron microscopy and energy dispersive X-ray spectroscopy (TEM-EDS), we describe the key aspects that characterize the interaction between an aquatic organism of global ecological and economic importance, the early larval stage of the Japanese oyster (Crassostrea gigas), and model gold NPs dispersed in their environment...
July 11, 2018: Nanotoxicology
Eşref Demir, Ricard Marcos
Boron and boron nitride nanotubes (BNNTs) are increasingly used in different industrial fields and, potentially, in some biomedical areas. As occurs with other nanomaterials (NMs), to increase our knowledge on their potential health hazards is a priority. Although in vitro approaches are a routine in getting biological information on the biological effects of NMs, the use of simple in vivo model organisms is receiving an increased interest. In this context, Drosophila melanogaster is widely used as a eukaryotic model for the study of the potential harmful effects associated with various agents, including NMs...
June 28, 2018: Nanotoxicology
L F Marques-Santos, G Grassi, E Bergami, C Faleri, T Balbi, A Salis, G Damonte, L Canesi, I Corsi
In order to assess the impact of nanoplastics on marine species, polystyrene nanoparticles (PS NPs) have been largely used as model particles. Here we studied the effects of 50 nm amino-modified PS-NH2 on Mediterranean sea urchin Paracentrotus lividus immune system cells (coelomocytes) in the presence of celomic fluid (CF) and at different NP concentrations (1, 5, 10, and 25 μg mL-1 ) and experimental conditions (absence or presence of EDTA). PS-NH2 acquired a protein corona once incubated with CF, dominated by the toposome precursor protein (TPP)...
June 27, 2018: Nanotoxicology
Vera L Maria, David Licha, Christina Ranninger, Janeck J Scott-Fordsmand, Christian G Huber, Mónica J B Amorim
The stress metabolome provides a thorough insight into the signals and hence mechanisms of response of organisms. This is an excellent tool to advance the understanding of interactions, especially for substances like nanomaterials (NMs), for which there is an urgent need for alternative methods for hazard assessment. The metabolome of Enchytraeus crypticus was studied for the first time. The case study, CuO NM (and CuCl2 ) covered exposure along a time frame [0-7-14 days (d)] and two reproduction effect concentrations (EC10 and EC50)...
June 22, 2018: Nanotoxicology
Shigeru Yamada, Daiju Yamazaki, Yasunari Kanda
Silver nanoparticles (AgNPs) have been widely used as consumer products due to their antibacterial activities. Despite their extensive use, AgNPs have been reported to cause various types of cytotoxicity, including neurotoxicity. However, the potential action of AgNPs on early fetal development has not been elucidated. This study determined the effects of AgNPs on neural induction in human induced pluripotent stem cells (iPSCs), used as a model for human fetal stage development. It was observed that exposure to AgNPs reduced the expression of several neural differentiation marker genes, including OTX2, an early biomarker for neurogenesis in iPSCs...
June 14, 2018: Nanotoxicology
Danail Hristozov, Lisa Pizzol, Gianpietro Basei, Alex Zabeo, Aiga Mackevica, Steffen Foss Hansen, Ilse Gosens, Flemming R Cassee, Wim de Jong, Antti Joonas Koivisto, Nicole Neubauer, Araceli Sanchez Jimenez, Elena Semenzin, Vrishali Subramanian, Wouter Fransman, Keld Alstrup Jensen, Wendel Wohlleben, Vicki Stone, Antonio Marcomini
The use of nano-scale copper oxide (CuO) and basic copper carbonate (Cu2 (OH)2 CO3 ) in both ionic and micronized wood preservatives has raised concerns about the potential of these substances to cause adverse humans health effects. To address these concerns, we performed quantitative (probabilistic) human health risk assessment (HHRA) along the lifecycles of these formulations used in antibacterial and antifungal wood coatings and impregnations by means of the EU FP7 SUN project's Decision Support System (SUNDS, www...
June 12, 2018: Nanotoxicology
Wei Wu, Liang Yan, Siyu Chen, Qiyou Li, Zhanjun Gu, Haiwei Xu, Zheng Qin Yin
Graphene and its derivatives are widely used for a variety of industrial, biomedical, and environmental applications. However, the potential harm caused by exposure of the eyes to graphene-based nanomaterials is scarce. Given the potential for these materials to be used in multiple applications, there is a pressing need to evaluate their ocular toxicity, and understand the relationships between their physico-chemical properties and the resulting toxicity. In this study, the toxicity of PEGylated graphene oxide (PEG-GO) with differing oxidation levels and/or surface charges (positive, negative and neutral charge) was evaluated using two in-vitro models of the eye: primary human corneal epithelial cells and human retinal capillary endothelial cells...
June 9, 2018: Nanotoxicology
Azadi Golbamaki, Nazanin Golbamaki, Natalia Sizochenko, Bakhtiyor Rasulev, Jerzy Leszczynski, Emilio Benfenati
The genetic toxicology of nanomaterials is a crucial toxicology issue and one of the least investigated topics. Substantially, the genotoxicity of metal oxide nanomaterials' data is resulting from in vitro comet assay. Current contributions to the genotoxicity data assessed by the comet assay provide a case-by-case evaluation of different types of metal oxides. The existing inconsistency in the literature regarding the genotoxicity testing data requires intelligent assessment strategies, such as weight of evidence evaluation...
June 9, 2018: Nanotoxicology
Jim E Riviere, Majid Jaberi-Douraki, James Lillich, Tahmineh Azizi, Hyun Joo, Kyoungju Choi, Ravi Thakkar, Nancy A Monteiro-Riviere
A detailed understanding of the factors governing nanomaterial biodistribution is needed to rationally design safe nanomedicines. This research details the pharmacokinetics of gold nanoparticle (AuNP) biodistribution after arterial infusion of 40 or 80 nm AuNP (1 μg/ml) into the isolated perfused porcine skin flap (IPPSF). AuNP had surface coatings consisting of neutral polyethylene glycol (PEG), anionic lipoic acid (LA), or cationic branched polyethylenimine (BPEI). Effect of a porcine plasma corona (PPC) on 40 nm BPEI and PEG-AuNP were assessed in the IPPSF...
June 1, 2018: Nanotoxicology
In-Chul Lee, Je-Won Ko, Sung-Hyeuk Park, Na-Rae Shin, In-Sik Shin, Changjong Moon, Sung-Ho Kim, Won-Kee Yun, Hyoung-Chin Kim, Jong-Choon Kim
Copper nanoparticles (Cu NPs) have various uses, including as additives in polymers/plastics, lubricants for metallic coating, and biomedical applications. We investigated the role of transforming growth factor (TGF)-β1 signaling in hepatic damage caused by Cu NPs and explored the effects of a 28-day repeated oral administration to Cu NPs on the immune response. The exposure to Cu NPs caused a dose-dependent increase in Cu levels in the liver and spleen. Cu NPs caused hepatic damage and markedly increased oxidative stress in liver tissues...
May 30, 2018: Nanotoxicology
Marit Ilves, Sara Vilske, Kukka Aimonen, Hanna K Lindberg, Saila Pesonen, Irene Wedin, Markus Nuopponen, Esa Vanhala, Casper Højgaard, Jakob R Winther, Martin Willemoës, Ulla Vogel, Henrik Wolff, Hannu Norppa, Kai Savolainen, Harri Alenius
Nanofibrillated cellulose (NFC) is a renewable nanomaterial that has beneficial uses in various applications such as packaging materials and paper. Like carbon nanotubes (CNT), NFCs have high aspect ratio and favorable mechanical properties. The aspect ratio also rises a concern whether NFC could pose a health risk and induce pathologies, similar to those triggered by multi-walled CNT. In this study, we explored the immunomodulatory properties of four NFCs in vitro and in vivo, and compared the results with data on bulk-sized cellulose fibrils and rigid multi-walled CNT (rCNT)...
May 30, 2018: Nanotoxicology
Youngju Han, Dong-Keon Lee, Sung-Hyun Kim, Seonghan Lee, Soyeon Jeon, Wan-Seob Cho
Due to the exponential increase in the development and utilization of rare earth oxide nanoparticles (REO NPs) in various fields, the possibility of exposure in humans by inhalation has increased. However, there are little information about hazards of REO NPs and its mechanisms of toxicity. In this study, we evaluated the acute pulmonary inflammation using 10 REO NPs (Dy2 O3 , Er2 O3 , Eu2 O3 , Gd2 O3 La2 O3 , Nd2 O3 , Pr6 O11 , Sm2 O3 , Tb4 O7 , and Y2 O3 ) and four well-known toxic particles (CuO, NiO, ZnO, and DQ12)...
May 30, 2018: Nanotoxicology
Ruhung Wang, Michael Lee, Karina Kinghorn, Tyler Hughes, Ishwar Chuckaree, Rishabh Lohray, Erik Chow, Paul Pantano, Rockford Draper
To understand the influence of carboxylation on the interaction of carbon nanotubes with cells, the amount of pristine multi-walled carbon nanotubes (P-MWNTs) or carboxylated multi-walled carbon nanotubes (C-MWNTs) coated with Pluronic® F-108 that were accumulated by macrophages was measured by quantifying CNTs extracted from cells. Mouse RAW 264.7 macrophages and differentiated human THP-1 (dTHP-1) macrophages accumulated 80-100 times more C-MWNTs than P-MWNTs during a 24-h exposure at 37 °C. The accumulation of C-MWNTs by RAW 264...
May 26, 2018: Nanotoxicology
Seraina Beyeler, Savvina Chortarea, Barbara Rothen-Rutishauser, Alke Petri-Fink, Peter Wick, Stefan A Tschanz, Christophe von Garnier, Fabian Blank
The risks of occupational exposure during handling of multi-walled carbon nanotubes (MWCNTs) have received limited attention to date, in particular for potentially susceptible individuals with highly prevalent chronic obstructive pulmonary disease (COPD). In this in vitro study, we simulated acute inhalation of MWCNTs employing an air-liquid interface cell exposure (ALICE) system: primary human bronchial epithelial cells from COPD patients and healthy donors (controls), cultured at the air-liquid interface (ALI) were exposed to MWCNTs...
May 26, 2018: Nanotoxicology
Francesca Cappellini, Yolanda Hedberg, Sarah McCarrick, Jonas Hedberg, Remco Derr, Giel Hendriks, Inger Odnevall Wallinder, Hanna L Karlsson
An increasing use of cobalt (Co)-based nanoparticles (NPs) in different applications and exposures at occupational settings triggers the need for toxicity assessment. Improved understanding regarding the physiochemical characteristics of Co metal NPs and different oxides in combination with assessment of toxicity and mechanisms may facilitate decisions for grouping during risk assessment. The aim of this study was to gain mechanistic insights in the correlation between NP reactivity and toxicity of three different Co-based NPs (Co, CoO, and Co3 O4 ) by using various tools for characterization, traditional toxicity assays, as well as six reporter cell lines (ToxTracker) for rapid detection of signaling pathways of relevance for carcinogenicity...
May 23, 2018: Nanotoxicology
Chang Guo, Alison Buckley, Tim Marczylo, Joanna Seiffert, Isabella Römer, James Warren, Alan Hodgson, Kian Fan Chung, Timothy W Gant, Rachel Smith, Martin O Leonard
Experimental modeling to identify specific inhalation hazards for nanomaterials has in the main focused on in vivo approaches. However, these models suffer from uncertainties surrounding species-specific differences and cellular targets for biologic response. In terms of pulmonary exposure, approaches which combine 'inhalation-like' nanoparticulate aerosol deposition with relevant human cell and tissue air-liquid interface cultures are considered an important complement to in vivo work. In this study, we utilized such a model system to build on previous results from in vivo exposures, which highlighted the small airway epithelium as a target for silver nanoparticle (AgNP) deposition...
May 11, 2018: Nanotoxicology
Yueli Chen, Jinquan Li, Zhongxue Yuan, Jianghua Feng, Zhong Chen
Core-shell structured Fe3 O4 @SiO2 -NH2 nanoparticles (Fe@Si-NPs) demonstrated outstanding potentials in drug targeting and delivery and medical imaging. However, they have limited clinical applications due to unknown chronic bio-effects and potential bio-related risks. In this study, the subchronic biological effects and metabolic fate of 20 nm Fe@Si-NPs in Sprague-Dawley rats in 12 weeks were investigated by the biochemical assay and NMR-based metabonomic analysis using an intravenous model. Biofluids (plasma and urine) analysis provided the transportation, absorption, and excretion information of Fe@Si-NPs...
May 10, 2018: Nanotoxicology
Yke Jildouw Arnoldussen, Vidar Skaug, Mona Aleksandersen, Erik Ropstad, Kristine Haugen Anmarkrud, Elin Einarsdottir, Fang Chin-Lin, Cesilie Granum Bjørklund, Mayes Kasem, Einar Eilertsen, Ron N Apte, Shanbeh Zienolddiny
Upon inhalation, multi-walled carbon nanotubes (MWCNTs) may reach the subpleura and pleural spaces, and induce pleural inflammation and/or mesothelioma in humans. However, the mechanisms of MWCNT-induced pathology after direct intrapleural injections are still only partly elucidated. In particular, a role of the proinflammatory interleukin-1 (IL-1) cytokines in pleural inflammation has so far not been published. We examined the MWCNT-induced pleural inflammation, gene expression abnormalities, and the modifying role of IL-1α and β cytokines following intrapleural injection of two types of MWCNTs (CNT-1 and CNT-2) compared with crocidolite asbestos in IL-1 wild-type (WT) and IL-1α/β KO (IL1-KO) mice...
May 9, 2018: Nanotoxicology
Guoliang Li, Lihong Liang, Jingchao Yang, Lihai Zeng, Zhiwei Xie, Yizhou Zhong, Xiaolin Ruan, Ming Dong, Zhanhong Yang, Guanchao Lai, Weixin Huang, Aichu Yang, Jiabing Chen, Banghua Wu, Huaming Xu, Dezhi Meng, Shijie Hu, Lihua Xia, Xingfen Yang, Laiyu Li, Sahoko Ichihara, Gaku Ichihara, Hanlin Huang, Zhenlie Huang
Calcium carbonate nanomaterials (nano-CaCO3 ) are widely used in both manufacturing and consumer products, but their potential health hazards remain unclear. The objective of this study was to survey workplace exposure levels and health effects of workers exposed to nano-CaCO3 . Personal and area sampling, as well as real-time and dust monitoring, were performed to characterize mass exposure, particle size distribution, and particle number exposure. A total of 56 workers (28 exposed workers and 28 unexposed controls) were studied in a cross-sectional study...
May 6, 2018: Nanotoxicology
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