journal
MENU ▼
Read by QxMD icon Read
search

Nanotoxicology

journal
https://www.readbyqxmd.com/read/28368214/iron-phosphate-nanoparticles-for-food-fortification-biological-effects-in-rats-and-human-cell-lines
#1
Lea M von Moos, Mirjam Schneider, Florentine M Hilty, Monika Hilbe, Myrtha Arnold, Nathalie Ziegler, Diogo Sales Mato, Hans Winkler, Mohamed Tarik, Christian Ludwig, Hanspeter Naegeli, Wolfgang Langhans, Michael B Zimmermann, Shana J Sturla, Ioannis A Trantakis
Nanotechnology offers new opportunities for providing health benefits in foods. Food fortification with iron phosphate nanoparticles (FePO4 NPs) is a promising new approach to reducing iron deficiency because FePO4 NPs combine high bioavailability with superior sensory performance in difficult to fortify foods. However, their safety remains largely untested. We fed rats for 90 days diets containing FePO4 NPs at doses at which iron sulfate (FeSO4), a commonly used food fortificant, has been shown to induce adverse effects...
April 20, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28420299/surface-chemistry-of-gold-nanoparticles-determines-the-biocorona-composition-impacting-cellular-uptake-toxicity-and-gene-expression-profiles-in-human-endothelial-cells
#2
Parwathy Chandran, Jim E Riviere, Nancy A Monteiro-Riviere
This study investigated the role of nanoparticle size and surface chemistry on biocorona composition and its effect on uptake, toxicity and cellular responses in human umbilical vein endothelial cells (HUVEC), employing 40 and 80 nm gold nanoparticles (AuNP) with branched polyethyleneimine (BPEI), lipoic acid (LA) and polyethylene glycol (PEG) coatings. Proteomic analysis identified 59 hard corona proteins among the various AuNP, revealing largely surface chemistry-dependent signature adsorbomes exhibiting human serum albumin (HSA) abundance...
April 19, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28415888/bioengineered-gold-nanoparticles-targeted-to-mesenchymal-cells-from-patients-with-bronchiolitis-obliterans-syndrome-does-not-rise-the-inflammatory-response-and-can-be-safely-inhaled-by-rodents
#3
Emanuela Cova, Simona Inghilleri, Laura Pandolfi, Monica Morosini, Sara Magni, Miriam Colombo, Davide Piloni, Chiara Finetti, Gabriele Ceccarelli, Laura Benedetti, Maria Gabriella Cusella, Manuela Agozzino, Fabio Corsi, Raffaele Allevi, Simona Mrakic-Sposta, Sarah Moretti, Simona De Gregori, Davide Prosperi, Federica Meloni
The use of gold nanoparticles as drug delivery system represents a promising issue for diseases without effective pharmacological treatment due to insufficient local drug accumulation and excessive systemic toxicity. Bronchiolitis obliterans syndrome (BOS) represents about 70% of cases of chronic lung allograft dysfunction, the main challenge to long term lung transplantation. It is believed that due to repeated insults to epithelial bronchiolar cells local inflammatory response creates a milieu that favours epithelial mesenchymal transition and activation of local mesenchymal cells leading to airway fibro-obliteration...
April 18, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28368775/neuronal-erk-signaling-in-response-to-graphene-oxide-in-nematode-caenorhabditis-elegans
#4
Man Qu, Yunhui Li, Qiuli Wu, Yankai Xia, Dayong Wang
ERK signaling is one of the important mitogen activated protein kinases (MAPKs). However, the role of ERK signaling in the regulation of response to engineered nanomaterial exposure is still largely unclear. In this study, using in vivo assay system of Caenorhabditis elegans, we investigated the function of ERK signaling in response to graphene oxide (GO) exposure and the underlying molecular mechanism. GO exposure increased the expression of MEK-2/MEK and MPK-1/ERK in the ERK signaling pathway. Mutation of mek-2 or mpk-1 resulted in a susceptibility to GO toxicity...
April 3, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28301273/a-cross-sectional-study-of-changes-in-markers-of-immunological-effects-and-lung-health-due-to-exposure-to-multi-walled-carbon-nanotubes
#5
Jelle Vlaanderen, Anjoeka Pronk, Nathaniel Rothman, Allan Hildesheim, Debra Silverman, H Dean Hosgood, Suzanne Spaan, Eelco Kuijpers, Lode Godderis, Peter Hoet, Qing Lan, Roel Vermeulen
BACKGROUND: Multi-wall carbon nanotubes (MWCNTs) are manufactured nanomaterials to which workers and the general population will be increasingly exposed in coming years. Little is known about potential human health effects of exposure to MWCNTs, but effects on the lung and the immune system have been reported in animal and mechanistic studies. OBJECTIVES: We conducted a cross-sectional study to assess the association between occupational exposure to MWCNTs and effects on lung health and the immune system...
April 3, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28290735/quantitative-biokinetics-of-titanium-dioxide-nanoparticles-after-intratracheal-instillation-in-rats-part-3
#6
Wolfgang G Kreyling, Uwe Holzwarth, Nadine Haberl, Ján Kozempel, Alexander Wenk, Stephanie Hirn, Carsten Schleh, Martin Schäffler, Jens Lipka, Manuela Semmler-Behnke, Neil Gibson
The biokinetics of a size-selected fraction (70 nm median size) of commercially available and (48)V-radiolabeled [(48)V]TiO2 nanoparticles has been investigated in healthy adult female Wistar-Kyoto rats at retention time-points of 1 h, 4 h, 24 h, 7 d and 28 d after intratracheal instillation of a single dose of an aqueous [(48)V]TiO2-nanoparticle suspension. A completely balanced quantitative biodistribution in all organs and tissues was obtained by applying typical [(48)V]TiO2-nanoparticle doses in the range of 40-240 μg·kg(-1) bodyweight and making use of the high sensitivity of the radiotracer technique...
April 3, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28290734/quantitative-biokinetics-of-titanium-dioxide-nanoparticles-after-oral-application-in-rats-part-2
#7
Wolfgang G Kreyling, Uwe Holzwarth, Carsten Schleh, Ján Kozempel, Alexander Wenk, Nadine Haberl, Stephanie Hirn, Martin Schäffler, Jens Lipka, Manuela Semmler-Behnke, Neil Gibson
The biokinetics of a size-selected fraction (70 nm median size) of commercially available and (48)V-radiolabeled [(48)V]TiO2 nanoparticles has been investigated in female Wistar-Kyoto rats at retention timepoints 1 h, 4 h, 24 h and 7 days after oral application of a single dose of an aqueous [(48)V]TiO2-nanoparticle suspension by intra-esophageal instillation. A completely balanced quantitative body clearance and biokinetics in all organs and tissues was obtained by applying typical [(48)V]TiO2-nanoparticle doses in the range of 30-80 μg•kg(-1) bodyweight, making use of the high sensitivity of the radiotracer technique...
April 3, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28290717/quantitative-biokinetics-of-titanium-dioxide-nanoparticles-after-intravenous-injection-in-rats-part-1
#8
Wolfgang G Kreyling, Uwe Holzwarth, Nadine Haberl, Ján Kozempel, Stephanie Hirn, Alexander Wenk, Carsten Schleh, Martin Schäffler, Jens Lipka, Manuela Semmler-Behnke, Neil Gibson
Submicrometer TiO2 particles, including nanoparticulate fractions, are used in an increasing variety of consumer products, as food additives and also drug delivery applications are envisaged. Beyond exposure of occupational groups, this entails an exposure risk to the public. However, nanoparticle translocation from the organ of intake and potential accumulation in secondary organs are poorly understood and in many investigations excessive doses are applied. The present study investigates the biokinetics and clearance of a low single dose (typically 40-400 μg/kg BW) of (48)V-radiolabeled, pure TiO2 anatase nanoparticles ([(48)V]TiO2NP) with a median aggregate/agglomerate size of 70 nm in aqueous suspension after intravenous (IV) injection into female Wistar rats...
April 3, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28287003/non-specific-adsorption-of-complement-proteins-affects-complement-activation-pathways-of-gold-nanomaterials
#9
Quang Huy Quach, James Chen Yong Kah
The complement system is a key humoral component of innate immunity, serving as the first line of defense against intruders, including foreign synthetic nanomaterials. Although gold nanomaterials (AuNMs) are widely used in nanomedicine, their immunological response is not well understood. Using AuNMs of three shapes commonly used in biomedical applications: spherical gold nanoparticles, gold nanostars and gold nanorods, we demonstrated that AuNMs activated whole complement system, leading to the formation of SC5b-9 complex...
April 3, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28285566/involvement-of-the-cytokine-ido1-ahr-loop-in-zinc-oxide-nanoparticle-induced-acute-pulmonary-inflammation
#10
Chia-Chi Ho, Hui-Ling Lee, Chao-Yu Chen, Yueh-Hsia Luo, Ming-Hsien Tsai, Hui-Ti Tsai, Pinpin Lin
Zinc oxide nanoparticles (ZnONPs) are widely used in our daily life, such as in sunscreens and electronic nanodevices. However, pulmonary exposure to ZnONPs causes acute pulmonary inflammation, which is considered as an initial event for various respiratory diseases. Thus, elucidation of the underlying cellular mechanisms of ZnONPs can help us in predicting their potential effects in respiratory diseases. In this study, we observed that ZnONPs increased proinflammatory cytokines, accompanied with an increased expression of aryl hydrocarbon receptor (AhR) and its downstream target cytochrome P450 1A1 (CYP1A1) in macrophages in vitro and in mouse lung epithelia in vivo...
April 3, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28358292/pulmonary-exposure-to-metallic-nanomaterials-during-pregnancy-irreversibly-impairs-lung-development-of-the-offspring
#11
Emmanuel Paul, Marie-Laure Franco-Montoya, Erwan Paineau, Bernard Angeletti, Shamila Vibhushan, Audrey Ridoux, Arnaud Tiendrebeogo, Murielle Salome, Bernhard Hesse, Delphine Vantelon, Jérôme Rose, Florence Canouï-Poitrine, Jorge Boczkowski, Sophie Lanone, Christophe Delacourt, Jean-Claude Pairon
Due to the growing commercial applications of manufactured nanoparticles, toxicological studies on nanoparticles, especially during the critical window of development, are of major importance. The aim of the study was to assess the impact of respiratory exposure to metallic and metal oxide nanoparticles during pregnancy on lung development of the offspring and to determine the key parameters involved in lung alterations. Pregnant mice were exposed to weekly doses of 100 µg (total dose 300 µg) of titanium dioxide (TiO2), cerium oxide (CeO2), silver (Ag) nanoparticles or saline solution by nonsurgical intratracheal instillation...
March 30, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28286999/an-assessment-of-the-importance-of-exposure-routes-to-the-uptake-and-internal-localisation-of-fluorescent-nanoparticles-in-zebrafish-danio-rerio-using-light-sheet-microscopy
#12
L M Skjolding, G Ašmonaitė, R I Jølck, T L Andresen, H Selck, A Baun, J Sturve
A major challenge in nanoecotoxicology is finding suitable methods to determine the uptake and localisation of nanoparticles on a whole-organism level. Some uptake methods have been associated with artefacts induced by sample preparation, including staining for electron microscopy. This study used light sheet microscopy (LSM) to define the uptake and localisation of fluorescently labelled nanoparticles in living organisms with minimal sample preparation. Zebrafish (Danio rerio) were exposed to fluorescent gold nanoparticles (Au NPs) and fluorescent polystyrene NPs via aqueous or dietary exposure...
March 29, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28285553/carbon-nanopowder-acts-as-a-trojan-horse-for-benzo-%C3%AE-pyrene-in-danio-rerio-embryos
#13
A Binelli, L Del Giacco, N Santo, L Bini, S Magni, M Parolini, L Madaschi, A Ghilardi, D Maggioni, M Ascagni, A Armini, L Prosperi, C Landi, C La Porta, C Della Torre
Carbon-based nanoparticles (CBNs) are largely distributed worldwide due to fossil fuel combustion and their presence in many consumer products. In addition to their proven toxicological effects in several biological models, attention in recent years has focussed on the role played by CBNs as Trojan-horse carriers for adsorbed environmental pollutants. This role has not been conclusively determined to date because CBNs can decrease the bioavailability of contaminants or represent an additional source of intake...
March 28, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28330416/the-way-to-cover-prediction-for-cytotoxicity-for-all-existing-nano-sized-metal-oxides-by-using-neural-network-method
#14
Natalja Fjodorova, Marjana Novic, Agnieszka Gajewicz, Bakhtiyor Rasulev
The regulatory agencies should fulfil the data gap in toxicity for new chemicals including nano-sized compounds, like metal oxides nanoparticles (MeOx NPs) according to the REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) legislation policy. The present study demonstrates the perspective capability of neural network models for prediction of cytotoxicity of MeOx NPs to bacteria Escherichia coli (E. coli) for the widest range of metal oxides extracted from Periodic table. The Counter Propagation Artificial Neural Network (CP ANN) models for prediction of cytotoxicity of MeOx NPs for data sets of 17, 36 and 72 metal oxides were employed in the study...
March 23, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28326861/cutaneous-applied-nano-zno-reduce-the-ability-of-hair-follicle-stem-cells-to-differentiate
#15
Wei Ge, Yong Zhao, Fang-Nong Lai, Jing-Cai Liu, Yuan-Chao Sun, Jun-Jie Wang, Shun-Feng Cheng, Xi-Feng Zhang, Li-Lan Sun, Lan Li, Paul W Dyce, Wei Shen
The ability of metal oxide nanoparticles to penetrate the skin has aroused a great deal of interest during the past decade due to concerns over the safety of topically applied sunscreens that contain physical UV-resistant metal particles, such as nano-Zinc oxide (nZnO). Previous studies demonstrate that metal oxide nanoparticles accumulate in skin furrows and hair follicles following topical application while little is known about the consequence of these nanoparticles on skin homeostasis. The current investigation tested the effects of nZnO (0...
March 22, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28277981/multi-target-qstr-modeling-for-simultaneous-prediction-of-multiple-toxicity-endpoints-of-nano-metal-oxides
#16
Nikita Basant, Shikha Gupta
The metal oxide nanoparticles (MeONPs) due to their unique physico-chemical properties have widely been used in different products. Current studies have established toxicity of some NPs to human and environment, hence, imply for their comprehensive safety assessment. Here, the potential of using a multi-target QSTR modeling for simultaneous prediction of multiple toxicity endpoints of various MeONPs has been investigated. A multi-target QSTR model has been established using four different experimental toxicity data sets of MeONPs...
March 22, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28318347/teratogenic-hazard-of-bpei-coated-silver-nanoparticles-to-xenopus-laevis
#17
Anita Colombo, Melissa Saibene, Elisa Moschini, Patrizia Bonfanti, Maddalena Collini, Kaja Kasemets, Paride Mantecca
Silver nanoparticles (AgNPs) are among the most exploited antimicrobial agents and are used in many consumer products. Size and surface reactivity are critical physico-chemical properties responsible for NPs toxicity, and surface coatings, often used to functionalize or stabilize AgNPs, can influence their toxic profile and biocompatibility. In the current study the developmental toxicity of 1) negatively charged citrate-coated AgNPs (Cit-AgNPs), 2) positively charged branched polyethylenimine-coated AgNPs (BPEI-AgNPs), and 3) Ag(+) (from 0...
March 20, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28303735/what-can-nanosafety-learn-from-drug-development-the-feasibility-of-safety-by-design
#18
Rune Hjorth, Lilian van Hove, Fern Wickson
"Safety by design" (SbD) is an intuitively appealing concept that is on the rise within nanotoxicology and nanosafety research, as well as within nanotechnology research policy. It leans on principles established within drug discovery and development (DDD) and seeks to address safety early, as well as throughout product development. However, it remains unclear what the concept of SbD exactly entails for engineered nanomaterials (ENMs) or how it is envisioned to be implemented. Here, we review the concept as it is emerging in European research and compare its resemblance with the safety testing and assessment practices in DDD...
March 17, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28281851/antibacterial-activity-and-biofilm-inhibition-by-surface-modified-titanium-alloy-medical-implants-following-application-of-silver-titanium-dioxide-and-hydroxyapatite-nanocoatings
#19
A Besinis, S D Hadi, H R Le, C Tredwin, R D Handy
One of the most common causes of implant failure is peri-implantitis, which is caused by bacterial biofilm formation on the surfaces of dental implants. Modification of the surface nanotopography has been suggested to affect bacterial adherence to implants. Silver nanoparticles are also known for their antibacterial properties. In this study, titanium alloy implants were surface modified following silver plating, anodisation and sintering techniques to create a combination of silver, titanium dioxide and hydroxyapatite (HA) nanocoatings...
March 17, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28277982/mapping-differential-cellular-protein-response-of-mouse-alveolar-epithelial-cells-to-multi-walled-carbon-nanotubes-as-a-function-of-atomic-layer-deposition-coating
#20
Gina M Hilton, Alexia J Taylor, Salik Hussain, Erinn C Dandley, Emily H Griffith, Stavros Garantziotis, Gregory N Parsons, James C Bonner, Michael S Bereman
Carbon nanotubes (CNTs), a prototypical engineered nanomaterial, have been increasingly manufactured for a variety of novel applications over the past two decades. However, since CNTs possess fiber-like shape and cause pulmonary fibrosis in rodents, there is concern that mass production of CNTs will lead to occupational exposure and associated pulmonary diseases. The aim of this study was to use contemporary proteomics to investigate the mechanisms of cellular response in E10 mouse alveolar epithelial cells in vitro after exposure to multi-walled CNTs (MWCNTs) that were functionalized by atomic layer deposition (ALD)...
March 13, 2017: Nanotoxicology
journal
journal
40853
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"