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Nanotoxicology

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https://www.readbyqxmd.com/read/28937306/biocompatibility-assessment-of-functionalized-magnetic-mesoporous-silica-nanoparticles-in-human-heparg-cells
#1
Cédric Pisani, Estelle Rascol, Christophe Dorandeu, Clarence Charnay, Yannick Guari, Joël Chopineau, Jean-Marie Devoisselle, Odette Prat
Magnetic mesoporous silica nanoparticles (M-MSNs) are a promising class of nanoparticles for drug delivery. However, a deep understanding of the toxicological mechanisms of action of these nanocarriers is essential, especially in the liver. The potential toxicity on HepaRG cells of pristine, pegylated (PEG), and lipid (DMPC) M-MSNs were compared. Based on MTT assay and real-time cell impedance, none of these NPs presented an extensive toxicity on hepatic cells. However, we observed by transmission electron microscopy (TEM) that the DMPC and pristine M-MSNs were greatly internalized...
September 22, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28937298/probing-the-toxicity-of-nanoparticles-a-unified-in-silico-machine-learning-model-based-on-perturbation-theory
#2
Riccardo Concu, Valeria V Kleandrova, Alejandro Speck-Planche, M Natália D S Cordeiro
Nanoparticles (NPs) are part of our daily life, having a wide range of applications in engineering, physics, chemistry, and biomedicine. However, there are serious concerns regarding the harmful effects that NPs can cause to the different biological systems and their ecosystems. Toxicity testing is an essential step for assessing the potential risks of the NPs, but the experimental assays are often very expensive and usually too slow to flag the number of NPs that may cause adverse effects. In silico models centered on quantitative structure-activity/toxicity relationships (QSAR/QSTR) are alternative tools that have become valuable supports to risk assessment, rationalizing the search for safer NPs...
September 22, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28901819/dna-methylation-changes-in-human-lung-epithelia-cells-exposed-to-multi-walled-carbon-nanotubes
#3
Marta I Sierra, Laura Rubio, Gustavo F Bayón, Isabel Cobo, Pablo Menendez, Paula Morales, Cristina Mangas, Rocio G Urdinguio, Virginia Lopez, Adolfo Valdes, Gerard Vales, Ricard Marcos, Ramon Torrecillas, Agustin F Fernández, Mario F Fraga
Humans are increasingly exposed to nanoparticles and, although many of their physiological effects have been described, the molecular mechanisms underlying them are still largely unknown. The present study aimed to determine the possible role of certain epigenetic mechanisms in the cellular response of human lung epithelial cells that are triggered by long-term exposure to titanium dioxide nanoparticles (TiO2NPs) and multi-walled carbon nanotubes (MWCNTs). The results showed that exposure to TiO2NPs had only minor effects on genome-wide DNA methylation...
September 13, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28885075/compnanotox2015-novel-perspectives-from-a-european-conference-on-computational-nanotoxicology-on-predictive-nanotoxicology
#4
Miguel A Bañares, Andrea Haase, Lang Tran, Vladimir Lobaskin, Günter Oberdörster, Robert Rallo, Jerzy Leszczynski, Peter Hoet, Rafi Korenstein, Barry Hardy, Tomasz Puzyn
A first European Conference on Computational Nanotoxicology, CompNanoTox, was held in November 2015 in Benahavís, Spain with the objectives to disseminate and integrate results from the European modeling and database projects (NanoPUZZLES, ModENPTox, PreNanoTox, MembraneNanoPart, MODERN, eNanoMapper and EU COST TD1204 MODENA) as well as to create synergies within the European NanoSafety Cluster. This conference was supported by the COST Action TD1204 MODENA on developing computational methods for toxicological risk assessment of engineered nanoparticles and provided a unique opportunity for cross fertilization among complementary disciplines...
September 8, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28885066/nanoparticle-size-specific-actin-rearrangement-and-barrier-dysfunction-of-endothelial-cells
#5
Yizhong Liu, Noga Rogel, Kei Harada, Leigha Jarett, Christopher H Maiorana, Guy K German, Gretchen J Mahler, Amber L Doiron
In this work, we evaluated the impact of gold nanoparticles on endothelial cell behavior and function beyond the influence on cell viability. Five types of gold nanoparticles were studied: 5 nm and 20 nm bare gold nanoparticles, 5 nm and 20 nm gold nanoparticles with biocompatible polyethylene glycol (PEG) coating and 60 nm bare gold nanoparticles. We found that all tested gold nanoparticles did not affect cell viability significantly and reduced the reactive oxygen species (ROS) level in endothelial cells...
September 8, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28830283/overview-on-biological-implications-of-metal-oxide-nanoparticle-exposure-to-human-alveolar-a549-cell-line
#6
Ansie Martin, Angshuman Sarkar
Metal oxides (MeOx) are exponentially being used in a wide range of applications and are the largest class of commercially produced nanomaterials. This presents unprecedented human exposure. Thus, understanding nanoparticle induced cellular stress can greatly help design strategies to combat them. Scores of studies have been carried out to understand the effects of MeOx nanoparticle exposure on human alveolar cells, which are highly susceptible to aerosolized matter. There is a huge redundancy of information generated, also, a lack of a comprehensive conglomeration of this information...
August 23, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28830271/the-acute-toxic-effects-of-silver-nanoparticles-on-myocardial-transmembrane-potential-ina-and-ik1-channels-and-heart-rhythm-in-mice
#7
Cai-Xia Lin, Su-Yu Yang, Jing-Li Gu, Jie Meng, Hai-Yan Xu, Ji-Min Cao
This study focused on the potential toxicity of silver nanoparticles (AgNPs) on cardiac electrophysiology which is rarely investigated. We found that AgNPs (10(-9)-10(-6 )g/ml) concentration-dependently depolarized the resting potential, diminished the action potential, and finally led to loss of excitability in mice cardiac papillary muscle cells in vitro. In cultured neonatal mice cardiomyocytes, AgNPs (10(-9)-10(-7 )g/ml) concentration-dependently decreased the Na(+) currents (INa), accelerated the activation, and delayed the inactivation and recovery of Na(+) channels from inactivation within 5 min...
August 23, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28816564/cytotoxicity-screening-and-cytokine-profiling-of-nineteen-nanomaterials-enables-hazard-ranking-and-grouping-based-on-inflammogenic-potential
#8
Kunal Bhattacharya, Gözde Kiliç, Pedro M Costa, Bengt Fadeel
Engineered nanomaterials (ENMs) are being produced for an increasing number of applications. Therefore, it is important to assess and categorize ENMs on the basis of their hazard potential. The immune system is the foremost defence against foreign bodies. Here we performed cytokine profiling of a panel of nineteen representative ENMs procured from the Joint Research Centre (JRC) and commercial sources. Physicochemical characterization was performed using dynamic light scattering. The ENMs were all shown to be endotoxin content free...
August 17, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28741972/the-effect-of-zirconium-doping-of-cerium-dioxide-nanoparticles-on-pulmonary-and-cardiovascular-toxicity-and-biodistribution-in-mice-after-inhalation
#9
Susan Dekkers, Mark R Miller, Roel P F Schins, Isabella Römer, Mike Russ, Rob J Vandebriel, Iseult Lynch, Marie-France Belinga-Desaunay, Eugenia Valsami-Jones, Shea P Connell, Ian P Smith, Rodger Duffin, John A F Boere, Harm J Heusinkveld, Catrin Albrecht, Wim H de Jong, Flemming R Cassee
Development and manufacture of nanomaterials is growing at an exponential rate, despite an incomplete understanding of how their physicochemical characteristics affect their potential toxicity. Redox activity has been suggested to be an important physicochemical property of nanomaterials to predict their biological activity. This study assessed the influence of redox activity by modification of cerium dioxide nanoparticles (CeO2 NPs) via zirconium (Zr) doping on the biodistribution, pulmonary and cardiovascular effects in mice following inhalation...
August 9, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28714804/cellular-proliferation-and-differentiation-induced-by-single-layer-molybdenum-disulfide-and-mediation-mechanisms-of-proteins-via-the-akt-mtor-p70s6k-signaling-pathway
#10
Wei Zou, Xingli Zhang, Mengyang Zhao, Qixing Zhou, Xiangang Hu
Single-layer molybdenum disulfide (SLMoS2) is a novel kind of 2D nanosheet that has attracted great attention regarding its use in biosensors, drug delivery, tissue engineering, and therapy. However, our results demonstrated that SLMoS2 accelerated proliferation and promoted myogenic differentiation and epithelial-mesenchymal transition (EMT) in human embryonic lung fibroblasts (HELFs). The abnormal proliferation and differentiation of HELFs contribute to idiopathic pulmonary fibrosis. Specifically, SLMoS2 significantly stimulated the expression of myofibroblast- and mesenchymal-associated genes and proteins...
August 2, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28707555/long-term-effects-of-silver-nanoparticles-in-caco-2-cells
#11
Laura Vila, Ricard Marcos, Alba Hernández
The high success of silver nanoparticles (AgNPs), mainly associated with their proved antimicrobial properties, has led to an increasing spread in our close environment. Although many studies have been carried out to detect potential toxicity of AgNPs, most of them have been developed under unrealistic exposure conditions. In terms of human risk, the evaluation of long-term exposures to subtoxic doses of NPs remains a challenge. Here, we have determined different transformation-related end points under a scenario of 6 weeks long-term exposure to low noncytotoxic AgNPs concentrations (0...
July 26, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28685628/bacteriomimetic-poly-%C3%AE-glutamic-acid-surface-coating-for-hemocompatibility-and-safety-of-nanomaterials
#12
Gayong Shim, Dongyoon Kim, Jinyoung Kim, Min Sung Suh, Youn Kyu Kim, Yu-Kyoung Oh
Poly-γ-glutamic acid (PGA), a major component of the bacterial capsule, is known to confer hydrophilicity to bacterial surfaces and protect bacteria from interactions with blood cells. We tested whether applying a bacteriomimetic surface coating of PGA modulates interactions of nanomaterials with blood cells or affects their safety and photothermal antitumor efficacy. Amphiphilic PGA (APGA), prepared by grafting phenylalanine residues to PGA, was used to anchor PGA to reduced graphene oxide (rGO) nanosheets, a model of hydrophobic nanomaterials...
July 26, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28671030/continuous-in-vitro-exposure-of-intestinal-epithelial-cells-to-e171-food-additive-causes-oxidative-stress-inducing-oxidation-of-dna-bases-but-no-endoplasmic-reticulum-stress
#13
Marie Dorier, David Béal, Caroline Marie-Desvergne, Muriel Dubosson, Frédérick Barreau, Eric Houdeau, Nathalie Herlin-Boime, Marie Carriere
The whitening and opacifying properties of titanium dioxide (TiO2) are commonly exploited when it is used as a food additive (E171). However, the safety of this additive can be questioned as TiO2 nanoparticles (TiO2-NPs) have been classed at potentially toxic. This study aimed to shed some light on the mechanisms behind the potential toxicity of E171 on epithelial intestinal cells, using two in vitro models: (i) a monoculture of differentiated Caco-2 cells and (ii) a coculture of Caco-2 with HT29-MTX mucus-secreting cells...
July 19, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28660804/evaluation-of-the-molecular-mechanisms-associated-with-cytotoxicity-and-inflammation-after-pulmonary-exposure-to-different-metal-rich-welding-particles
#14
Mohammad Shoeb, Vamsi Kodali, Breanne Farris, Lindsey M Bishop, Terence Meighan, Rebecca Salmen, Tracy Eye, Jenny R Roberts, Patti Zeidler-Erdely, Aaron Erdely, James M Antonini
Welding generates a complex aerosol of incidental nanoparticles and cytotoxic metals, such as chromium (Cr), manganese (Mn), nickel (Ni), and iron (Fe). The goal was to use both in vivo and in vitro methodologies to determine the mechanisms by which different welding fumes may damage the lungs. Sprague-Dawley rats were treated by intratracheal instillation (ITI) with 2.0 mg of gas metal arc-mild steel (GMA-MS) or manual metal arc-stainless steel (MMA-SS) fumes or saline (vehicle control). At 1, 3, and 10 days, bronchoalveolar lavage (BAL) was performed to measure lung toxicity...
July 18, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28669258/titanium-dioxide-nanoparticles-prime-a-specific-activation-state-of-macrophages
#15
Chao Huang, Mayu Sun, Yang Yang, Feng Wang, Xueqi Ma, Jingquan Li, Yilong Wang, Qiurong Ding, Hao Ying, Haiyun Song, Yongning Wu, Yiguo Jiang, Xudong Jia, Qian Ba, Hui Wang
Titanium dioxide nanoparticles (TiO2 NPs) are widely used in foods, cosmetics, and medicine. Although the inhalation toxicity of TiO2 NPs has been studied, the potential adverse effects of oral exposure of low-dose TiO2 NPs are largely unclear. Herein, with macrophage cell lines, primary cells, and mouse models, we show that TiO2 NPs prime macrophages into a specific activation state characterized by excessive inflammation and suppressed innate immune function. After a month of dietary exposure in mice or exposure in vitro to TiO2 NPs (10 and 50 nm), the expressions of pro-inflammatory genes in macrophages were increased, and the expressions of anti-inflammatory genes were decreased...
July 15, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28627335/effects-of-exposure-pathways-on-the-accumulation-and-phytotoxicity-of-silver-nanoparticles-in-soybean-and-rice
#16
Cheng-Cheng Li, Fei Dang, Min Li, Min Zhu, Huan Zhong, Holger Hintelmann, Dong-Mei Zhou
The widespread use of silver nanoparticles (AgNPs) raises concerns both about their accumulation in crops and human exposure via crop consumption. Plants take up AgNPs through their leaves and roots, but foliar uptake has been largely ignored. To better understand AgNPs-plant interactions, we compared the uptake, phytotoxicity and size distribution of AgNPs in soybean and rice following root versus foliar exposure. At similar AgNP application levels, foliar exposure led to 17-200 times more Ag bioaccumulation than root exposure...
July 7, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28618895/silver-nanoparticles-inhaled-during-pregnancy-reach-and-affect-the-placenta-and-the-foetus
#17
Luisa Campagnolo, Micol Massimiani, Lucia Vecchione, Diletta Piccirilli, Nicola Toschi, Andrea Magrini, Elena Bonanno, Manuel Scimeca, Luca Castagnozzi, Giorgio Buonanno, Luca Stabile, Francesco Cubadda, Federica Aureli, Paul Hb Fokkens, Wolfgang G Kreyling, Flemming R Cassee, Antonio Pietroiusti
Recently, interest for the potential impact of consumer-relevant engineered nanoparticles on pregnancy has dramatically increased. This study investigates whether inhaled silver nanoparticles (AgNPs) reach and cross mouse placental barrier and induce adverse effects. Apart from their relevance for the growing use in consumer products and biomedical applications, AgNPs are selected since they can be unequivocally identified in tissues. Pregnant mouse females are exposed during the first 15 days of gestation by nose-only inhalation to a freshly produced aerosol of 18-20 nm AgNPs for either 1 or 4 h, at a particle number concentration of 3...
July 7, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28673184/toxicogenomics-of-iron-oxide-nanoparticles-in-the-nematode-c-elegans
#18
Laura Gonzalez-Moragas, Si-Ming Yu, Núria Benseny-Cases, Stephen Stürzenbaum, Anna Roig, Anna Laromaine
We present a mechanistic study of the effect of iron oxide nanoparticles (SPIONs) in Caenorhabditis elegans combining a genome-wide analysis with the investigation of specific molecular markers frequently linked to nanotoxicity. The effects of two different coatings were explored: citrate, an anionic stabilizer, and bovine serum albumin, as a pre-formed protein corona. The transcriptomic study identified differentially expressed genes following an exposure to SPIONs. The expression of genes involved in oxidative stress, metal detoxification response, endocytosis, intestinal integrity and iron homeostasis was quantitatively evaluated...
July 4, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28617070/oral-subchronic-exposure-to-silver-nanoparticles-causes-renal-damage-through-apoptotic-impairment-and-necrotic-cell-death
#19
Ratnakar Tiwari, Radha Dutt Singh, Hafizurrahman Khan, Siddhartha Gangopadhyay, Sandeep Mittal, Vikas Singh, Nidhi Arjaria, Jai Shankar, Somendu Kumar Roy, Dhirendra Singh, Vikas Srivastava
Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials. Following oral exposure, AgNPs can accumulate in various organs including kidneys where they show gender specific accumulation. There is limited information on their effect on renal system following long-term animal exposure especially at the ultramicroscopic and molecular level. In this study, we have assessed the effect of 60 days oral AgNPs treatment on kidneys of female Wistar rats at doses of 50 ppm and 200 ppm that are below previously reported lowest observed adverse effect level (LOAEL)...
July 4, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28594294/ceo2-nanoparticles-alter-the-outcome-of-species-interactions
#20
Cheng Peng, Ying Chen, Zhichao Pu, Qing Zhao, Xin Tong, Yongsheng Chen, Lin Jiang
Despite considerable research on the environmental impacts of nanomaterials, we know little about how they influence interactions between species. Here, we investigated the acute (12 d) and chronic (64 d) toxicities of cerium oxide nanoparticles (CeO2 NPs) and bulk particles (0-200 mg/L) to three ciliated protist species (Loxocephalus sp., Paramecium aurelia, and Tetrahymena pyriformis) in single-, bi-, and multispecies microcosms. The results show that CeO2 NPs strongly affected the interactions between ciliated protozoan species...
June 23, 2017: Nanotoxicology
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