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Nanotoxicology

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https://www.readbyqxmd.com/read/30428752/human-keratinocytes-adapt-to-zno-nanoparticles-induced-toxicity-via-complex-paracrine-crosstalk-and-nrf2-proteasomal-signal-transduction
#1
Zhuoran Wu, Haibo Yang, Gautam Archana, Moumita Rakshit, Kee Woei Ng, Chor Yong Tay
Zinc oxide nanoparticles (Nano-ZnO) is currently one of the most extensively used inorganic particles in a wide range of skin care and consumable products. Therefore, examining the biological effects of Nano-ZnO, especially in the non-cytotoxic levels, thus holds important contemporary practical implications. Herein, our study demonstrates that long-term conditioning of human keratinocytes (HaCaTs) to non-cytoxic dose of Nano-ZnO (∼100 nm) can induce an adaptive response, leading to an enhancement of the cells tolerance against cytotoxic level of Nano-ZnO...
November 15, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30422028/endoplasmic-reticulum-stress-mediates-inflammatory-response-triggered-by-ultra-small-superparamagnetic-iron-oxide-nanoparticles-in-hepatocytes
#2
Chengyong He, Shengwei Jiang, Huan Yao, Liyin Zhang, Chuanli Yang, Denglin Zhan, Gan Lin, Yun Zeng, Yankai Xia, Zhongning Lin, Gang Liu, Yuchun Lin
Ultra-small superparamagnetic iron oxide nanoparticles (USPIO-NPs) are widely used as clinical magnetic resonance imaging contrast agents for hepatic diseases diagnosis. USPIO-NPs often damage the hepatocytes and affect the function of liver but its mechanism of action remains unclear. In the present study, USPIO-NPs caused higher cytotoxicity and lactate dehydrogenase (LDH) leakage in hepatic L02 cells than SPIO-NPs. Subsequently, USPIO-NPs affected more genes' expression than SPIO-NPs analyzed through microarray and bioinformatics analysis...
November 13, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30354872/toward-comprehension-of-multiple-human-cells-uptake-of-engineered-nano-metal-oxides-quantitative-inter-cell-line-uptake-specificity-qiclus-modeling
#3
Probir Kumar Ojha, Supratik Kar, Kunal Roy, Jerzy Leszczynski
To address the nanomaterial exposure threat, it is imperative to understand how nanomaterials are recognized, internalized, and distributed within diverse cell systems. Targeting of nanomaterials to a specific cell type is generally attained through the modification of the nanoparticle (NP) surface leading to required cellular uptake. The enhanced cellular uptake to normal cells can direct to the higher interaction of NPs with subcellular organelles resulting the provocation of various signaling pathways. The successes of NPs rely on the prospect for the synthesis of functionalized NPs with necessary properties and their enhanced potential for cellular uptake for specific targeting...
October 25, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30325693/deciphering-the-transcription-factor-microrna-target-gene-regulatory-network-associated-with-graphene-oxide-cytotoxicity
#4
Masoumeh Farahani, Mostafa Rezaei-Tavirani, Hakimeh Zali, Afsaneh Arefi Oskouie, Meisam Omidi, Alireza Lashay
Graphene oxide (GO) has recently emanated as a promising material in cancer treatment. To unveil the underlying mechanisms of microRNAs (miRNAs) and potential target genes involved in GO cytotoxicity, we firstly compiled GO-related miRNAs and genes in human cancer cell lines treated with GO from public databases and published works. Besides miRNAs as post-transcriptional regulators of gene expression, transcription factors (TFs) are also the main regulators at the transcriptional level. In the following, we explored the regulatory relationships between miRNAs, target genes, and TFs...
October 16, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30317900/role-of-p53-in-the-chronic-pulmonary-immune-response-to-tangled-or-rod-like-multi-walled-carbon-nanotubes
#5
Katherine S Duke, Elizabeth A Thompson, Mark D Ihrie, Alexia J Taylor-Just, Elizabeth A Ash, Kelly A Shipkowski, Jonathan R Hall, Debra A Tokarz, Mark F Cesta, Ann F Hubbs, Dale W Porter, Linda M Sargent, James C Bonner
The fiber-like shape of multi-walled carbon nanotubes (MWCNTs) is reminiscent of asbestos, suggesting they pose similar health hazards when inhaled, including pulmonary fibrosis and mesothelioma. Mice deficient in the tumor suppressor p53 are susceptible to carcinogenesis. However, the chronic pathologic effect of MWCNTs delivered to the lungs of p53 heterozygous (p53+/- ) mice has not been investigated. We hypothesized that p53+/- mice would be susceptible to lung tumor development after exposure to either tangled (t-) or rod-like (r-) MWCNTs...
October 14, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30317896/autophagy-dependent-release-of-zinc-ions-is-critical-for-acute-lung-injury-triggered-by-zinc-oxide-nanoparticles
#6
Xuejun Jiang, Qianghu Tang, Jun Zhang, Hong Wang, Lulu Bai, Pan Meng, Xia Qin, Ge Xu, Diptiman D Bose, Bin Wang, Chengzhi Chen, Zhen Zou
Pulmonary exposure to zinc oxide nanoparticles (ZnONPs) could cause acute lung injury (ALI), but the underlying molecular mechanism remains unclear. Herein, we established a ZnONPs-induced ALI mouse model, characterized by the histopathological changes (edema and infiltration of inflammatory cells in lung tissues), and the elevation of total protein and cytokine interleukin-6 in bronchoalveolar lavage fluid in time- and dose-dependent manners. This model also exhibited features like the disturbance of redox-state (reduced of glutathione to glutathione disulfide ratio, elevation of heme oxygenase-1 and superoxide dismutase 2), the decrease of adenosine triphosphate synthesis and the release of zinc ions in the lung tissues...
October 14, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30317887/uptake-and-molecular-impact-of-aluminum-containing-nanomaterials-on-human-intestinal-caco-2-cells
#7
Holger Sieg, Caroline Braeuning, Birgitta Maria Kunz, Hannes Daher, Claudia Kästner, Benjamin-Christoph Krause, Thomas Meyer, Pégah Jalili, Kevin Hogeveen, Linda Böhmert, Dajana Lichtenstein, Agnès Burel, Soizic Chevance, Harald Jungnickel, Jutta Tentschert, Peter Laux, Albert Braeuning, Fabienne Gauffre, Valérie Fessard, Jan Meijer, Irina Estrela-Lopis, Andreas F Thünemann, Andreas Luch, Alfonso Lampen
Aluminum (Al) is one of the most common elements in the earth crust and increasingly used in food, consumer products and packaging. Its hazard potential for humans is still not completely understood. Besides the metallic form, Al also exists as mineral, including the insoluble oxide, and in soluble ionic forms. Representatives of these three species, namely a metallic and an oxidic species of Al-containing nanoparticles and soluble aluminum chloride, were applied to human intestinal cell lines as models for the intestinal barrier...
October 14, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30265172/comparative-analysis-of-nanosystems-effects-on-human-endothelial-and-monocytic-cell-functions
#8
Jasmin Matuszak, Philipp Dörfler, Stefan Lyer, Harald Unterweger, Maya Juenet, Cédric Chauvierre, Amr Alaarg, Danielle Franke, Gunter Almer, Isabelle Texier, Josbert M Metselaar, Ruth Prassl, Christoph Alexiou, Harald Mangge, Didier Letourneur, Iwona Cicha
The objective of our work was to investigate the effects of different types of nanoparticles on endothelial (HUVEC) and monocytic cell functions. We prepared and tested 14 different nanosystems comprising liposomes, lipid nanoparticles, polymer, and iron oxide nanoparticles. Some of the tested nanosystems contained targeting, therapeutic, or contrast agent(s). The effect of particles (0-400 µg/mL) on endothelial-monocytic cell interactions in response to TNF-α was investigated using an arterial bifurcation model and dynamic monocyte adhesion assay...
September 28, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30257125/human-nasal-mucosal-c-reactive-protein-responses-after-inhalation-of-ultrafine-welding-fume-particles-positive-correlation-to-systemic-c-reactive-protein-responses
#9
R Baumann, P Brand, A Chaker, A Markert, I Rack, S Davatgarbenam, S Joraslafsky, B Gerhards, T Kraus, M Gube
Exposures to occupationally relevant ultrafine, zinc- and copper-containing welding fumes cause inflammatory responses involving systemic IL-6, C-reactive protein (CRP) and serum amyloid A (SAA), all associated with elevated risk of cardiovascular events. We investigated whether the systemic response is preceded by nasal inflammatory reactions. Fifteen nonsmoking male subjects were exposed for 6 h under controlled conditions to zinc-/copper-containing welding fumes (at 2.5 mg/m3 ) or ambient air control in a randomized order...
September 26, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30257117/activated-irhom2-drives-prolonged-pm-2-5-exposure-triggered-renal-injury-in-nrf2-defective-mice
#10
Min-Xuan Xu, Yu-Ting Qin, Chen-Xu Ge, Ting-Ting Gu, De-Shuai Lou, Qiang Li, Lin-Feng Hu, Yuan-Yuan Li, Wei-Wei Yang, Jun Tan
Research suggests that particulate matter (PM2.5 ) is a predisposing factor for metabolic syndrome-related systemic inflammation and oxidative stress injury. TNF-α as a major pro-inflammatory cytokine was confirmed to participate in various diseases. Inactive rhomboid protein 2 (iRhom2) was recently determined as a necessary regulator for shedding of TNF-α in immune cells. Importantly, kidney-resident macrophages are critical to inflammation-associated chronic renal injury. Podocyte injury can be induced by stimulants and give rise to nephritis, but how iRhom2 contributes to PM2...
September 26, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30253711/systematic-in-vivo-study-of-nio-nanowires-and-nanospheres-biodegradation-uptake-and-biological-impacts
#11
Mohamed Alaraby, Alba Hernández, Ricard Marcos
High aspect ratio nanomaterials (NM) have a promising future in medicine and industry as a unique category of NM. Consequently, it is important to evaluate their potential biological side-effects before crediting their use. To understand the mechanisms of degradation, internalisation, and interaction with different biological targets, we used the in vivo model Drosophila melanogaster to obtain a systematic and complete study on high aspect ratio Ni nanowires (NiNW), compared with low aspect ratio Ni nanospheres (NiNS), and NiSO4 as a model of agent releasing nickel ions...
September 25, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30251573/differential-toxicity-of-processed-and-non-processed-states-of-cocrmo-degradation-products-generated-from-a-hip-simulator-on-neural-cells
#12
Divya Rani Bijukumar, Abhijith Segu, YongChao Mou, Reza Ghodsi, Tolou Shokufhar, Mark Barba, Xue-Jun Li, Mathew Thoppil Mathew
Physico-chemical characteristics of the CoCrMo degradation products have played an important role in cytotoxicity and clinical complications on the orthopedic patients who have metal implants. Previous studies have limited reflection on the physicochemical characteristics of the degradation products generated in vivo, which are very different from individual metal particles and/or ions obtained from different commercial sources. In this study, we aimed to understand the differences in toxicity induced by the degradation products in as-synthesized form as well as those obtained after post-processing...
September 25, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30182784/preclinical-hazard-evaluation-strategy-for-nanomedicines
#13
Stefan Siegrist, Emre Cörek, Pascal Detampel, Jenny Sandström, Peter Wick, Jörg Huwyler
The increasing nanomedicine usage has raised concerns about their possible impact on human health. Present evaluation strategies for nanomaterials rely on a case-by-case hazard assessment. They take into account material properties, biological interactions, and toxicological responses. Authorities have also emphasized that exposure route and intended use should be considered in the safety assessment of nanotherapeutics. In contrast to an individual assessment of nanomaterial hazards, we propose in the present work a novel and unique evaluation strategy designed to uncover potential adverse effects of such materials...
September 5, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30182778/a-nanoinformatics-decision-support-tool-for-the-virtual-screening-of-gold-nanoparticle-cellular-association-using-protein-corona-fingerprints
#14
Antreas Afantitis, Georgia Melagraki, Andreas Tsoumanis, Eugenia Valsami-Jones, Iseult Lynch
The increasing use of nanoparticles (NPs) in a wide range of consumer and industrial applications has necessitated significant effort to address the challenge of characterizing and quantifying the underlying nanostructure - biological response relationships to ensure that these novel materials can be exploited responsibly and safely. Such efforts demand reliable experimental data not only in terms of the biological dose-response, but also regarding the physicochemical properties of the NPs and their interaction with the biological environment...
September 5, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30182776/grouping-of-nanomaterials-to-read-across-hazard-endpoints-a-review
#15
L Lamon, K Aschberger, D Asturiol, A Richarz, A Worth
The use of non-testing strategies like read-across in the hazard assessment of chemicals and nanomaterials (NMs) is deemed essential to perform the safety assessment of all NMs in due time and at lower costs. The identification of physicochemical (PC) properties affecting the hazard potential of NMs is crucial, as it could enable to predict impacts from similar NMs and outcomes of similar assays, reducing the need for experimental (and in particular animal) testing. This manuscript presents a review of approaches and available case studies on the grouping of NMs to read-across hazard endpoints...
September 5, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30182775/mechanism-of-long-term-toxicity-of-cuo-nps-to-microalgae
#16
Xingkai Che, Ruirui Ding, Yuting Li, Zishan Zhang, Huiyuan Gao, Wei Wang
Little is known regarding the detailed mechanism of CuO NPs' toxicity to microalgal primary metabolism pathway. Photosynthesis and respiration are the most important primary metabolism and the main sources of production of reactive oxygen species (ROS), but the effect of CuO NPs on both of them has not been systematically studied to date. Our research demonstrated that long-term treatment with CuO NPs significantly inhibited activities of photosynthesis and respiration in microalgae, and the photosynthesis was more sensitive to the toxicity of CuO NPs than respiration...
September 5, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30182770/evaluation-of-toxicological-and-teratogenic-effects-of-carbosilane-glucose-glycodendrimers-in-zebrafish-embryos-and-model-rodent-cell-lines
#17
Michaela Liegertová, Dominika Wrobel, Regina Herma, Monika Müllerová, Lucie Červenková Šťastná, Petra Cuřínová, Tomáš Strašák, Marek Malý, Jan Čermák, Jiří Smejkal, Marcel Štofik, Jan Maly
Glycodendrimers (Glyco-DDMs) represent a rapidly growing class of nanoparticles with promising properties for biomedical applications but concerns regarding the impact on human health and environment are still justified. Here we report, for the first time, the comparative study of in vivo developmental toxicity of carbosilane Glyco-DDMs and their cytotoxicity in vitro. Carbosilane Glyco-DDMs (generation 1-3) containing 4, 8, and 16 β-d-glucopyranosyl units at the periphery (DDM1 Glu, DDM2 Glu, and DDM3 Glu) were synthesized and characterized by 1 H, 13 C and 29 Si NMR, mass spectrometry, dynamic light scattering, atomic force microscopy (AFM), and computer modeling...
September 5, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30182766/insights-into-possibilities-for-grouping-and-read-across-for-nanomaterials-in-eu-chemicals-legislation
#18
A Mech, K Rasmussen, P Jantunen, L Aicher, M Alessandrelli, U Bernauer, E A J Bleeker, J Bouillard, P Di Prospero Fanghella, R Draisci, M Dusinska, G Encheva, G Flament, A Haase, Y Handzhiyski, F Herzberg, J Huwyler, N R Jacobsen, V Jeliazkov, N Jeliazkova, P Nymark, R Grafström, A G Oomen, M L Polci, C Riebeling, J Sandström, B Shivachev, S Stateva, S Tanasescu, R Tsekovska, H Wallin, M F Wilks, S Zellmer, M D Apostolova
This paper presents a comprehensive review of European Union (EU) legislation addressing the safety of chemical substances, and possibilities within each piece of legislation for applying grouping and read-across approaches for the assessment of nanomaterials (NMs). Hence, this review considers both the overarching regulation of chemical substances under REACH (Regulation (EC) No 1907/2006 on registration, evaluation, authorization, and restriction of chemicals) and CLP (Regulation (EC) No 1272/2008 on classification, labeling and packaging of substances and mixtures) and the sector-specific pieces of legislation for cosmetic, plant protection and biocidal products, and legislation addressing food, novel food, and food contact materials...
September 5, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/30132360/biodistribution-and-biocompatibility-of-passion-fruit-like-nano-architectures-in-zebrafish
#19
Marta d'Amora, Domenico Cassano, Salvador Pocoví-Martínez, Silvia Giordani, Valerio Voliani
Passion fruit-like nano-architectures (NAs) are all-in-one platforms of increasing interest for the translation of metal nanoparticles into clinics. NAs are nature-inspired disassembling inorganic theranostics, which jointly combine most of the appealing behaviors of noble metal nanoparticles with their potential organism excretion. Despite their unique and promising properties, NAs in vivo interactions and potential adverse effects have not yet been investigated. In this study, we employ zebrafish (Danio Rerio) to assess the development toxicity of NAs as well as their uptake and bioaccumulation at different stages of growth...
August 22, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29996704/co-exposure-to-silver-nanoparticles-and-cadmium-induce-metabolic-adaptation-in-hepg2-cells
#20
Renata Rank Miranda, Vladimir Gorshkov, Barbara Korzeniowska, Stefan J Kempf, Francisco Filipak Neto, Frank Kjeldsen
Although multiple studies have reported the toxicological effects and underlying mechanisms of toxicity of silver nanoparticles (AgNP) in a variety of organisms, the interactions of AgNP with environmental contaminants such as cadmium are poorly understood. We used biochemical assays and mass spectrometry-based proteomics to assess the cellular and molecular effects induced by a co-exposure of HepG2 cells to AgNP and cadmium. Cell viability and energy homeostasis were slightly affected after a 4-h exposure to AgNP, cadmium, or a combination of the two; these endpoints were substantially altered after a 24-h co-exposure to AgNP and cadmium, while exposure to one of the two contaminants led only to minor changes...
September 2018: Nanotoxicology
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