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International Journal of Immunogenetics

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https://www.readbyqxmd.com/read/28627089/analysis-of-ptpn22-zfat-and-myo9b-polymorphisms-in-turner-syndrome-and-risk-of-autoimmune-disease
#1
E Villanueva-Ortega, B Ahedo, M A Fonseca-Sánchez, J Pérez-Durán, N Garibay-Nieto, M T Macías-Galavíz, Y Trujillo-Cabrera, E García-Latorre, G Queipo
Turner syndrome (TS) is one of the most common sexual chromosome abnormalities and is clearly associated with an increased risk of autoimmune diseases, particularly thyroid disease and coeliac disease (CD). Single-nucleotide polymorphism analyses have been shown to provide correlative evidence that specific genes are associated with autoimmune disease. Our aim was to study the functional polymorphic variants of PTPN22 and ZFAT in relation to thyroid disease and those of MYO9B in relation to CD. A cross-sectional comparative analysis was performed on Mexican mestizo patients with TS and age-matched healthy females...
June 18, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28556460/hla-genotyping-using-the-illumina-hla-trusight-next-generation-sequencing-kits-a-comparison
#2
T Profaizer, E Lázár-Molnár, A Pole, J C Delgado, A Kumánovics
Illumina first introduced their TruSight human leucocyte antigen (HLA) next-generation sequencing (NGS) typing kit in 2015 and subsequently followed up with a new version in 2016. Here we report on our experience comparing the two versions of the Illumina HLA NGS kits.
May 28, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28547851/frequency-distribution-of-six-cytokine-gene-polymorphisms-in-north-and-south-italy
#3
A Santovito, C Gendusa, A Matini, F Ferraro, I Musso, M Costanzo, A Delclos, P Cervella
Allelic and genotype frequencies of four cytokine genes were obtained from 738 subjects from North- and South-Italy. Populations were in Hardy-Weinberg equilibrium for all genes but significantly differed in the frequency of all SNPs and three haplotypes. In the MDS graph, they were plotted in separate positions close to Europeans and an Ivorian population, respectively.
May 26, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28512917/nomenclature-for-factors-of-the-hla-system-update-february-2017
#4
S G E Marsh
No abstract text is available yet for this article.
May 16, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28503854/nomenclature-for-factors-of-the-hla-system-updated-on-january-2017
#5
S G E Marsh
No abstract text is available yet for this article.
May 15, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28503819/nomenclature-for-factors-of-the-hla-system-update-march-2017
#6
S G E Marsh
No abstract text is available yet for this article.
May 15, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28406554/vitamin-d-receptor-gene-polymorphisms-association-with-the-risk-of-sepsis-and-mortality
#7
K Zeljic, A Elkilany, G Supic, M Surbatovic, D Djordjevic, Z Magic, B Bozic
Association of vitamin D receptor (VDR) gene polymorphisms with sepsis risk and mortality was studied. VDR FokI CC genotype was associated with increased sepsis risk (OR = 13.396, p = .000009) compared to the TT genotype. Results suggest possible role of VDR FokI (rs2228570) as a molecular biomarker of increased sepsis risk.
April 12, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28383785/characterization-of-three-new-hla-class-i-alleles-in-spanish-caucasians-hla-a-02-620-hla-b-27-150-and-hla-b-07-05-01-02
#8
A Balas, D Planelles, P Montesinos, C Solano, J L Vicario
Three new HLA class I alleles, HLA-A*02:620, HLA-B*27:150 and HLA-B*07:05:01:02, were described in the Spanish Caucasoid population.
April 6, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28374494/immunogenetic-profiling-of-23-snps-of-cytokine-and-chemokine-receptor-genes-through-a-minisequencing-technique-design-development-and-validation
#9
J M Valverde-Villegas, R M de Medeiros, S E M Almeida, J A B Chies
The minisequencing technique offers accuracy and robustness to genotyping of polymorphic DNA variants, being an excellent option for the identification and analyses of prognostic/susceptibility markers in human diseases. Two multiplex minisequencing assays were designed and standardized to screen 23 candidate SNPs in cytokine, chemokine receptor and ligand genes previously associated with susceptibility to cancer and autoimmune disorders as well as to infectious diseases outcome. The SNPs were displayed in two separate panels (panel 1-IL2 rs2069762, TNFα rs1800629, rs361525; IL4 rs2243250; IL6 rs1800795; IL10 rs1800896, rs1800872; IL17A rs8193036, rs2275913 and panel 2-CCR3 rs309125, CCR4 rs6770096, rs2228428; CCR6 rs968334; CCR8 rs2853699; CXCR3 rs34334103, rs2280964;CXCR6 rs223435, rs2234358; CCL20 rs13034664, rs6749704; CCL22 rs4359426; CXCL10/IP-10 rs3921, rs56061981)...
April 4, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28371410/new-genes-associated-with-rheumatoid-arthritis-identified-by-gene-expression-profiling
#10
H Wang, J Guo, J Jiang, W Wu, X Chang, H Zhou, Z Li, J Zhao
In this study, we aimed to find new genes associated with rheumatoid arthritis (RA) so that more comprehensive genes would be used for monitoring and/or diagnosing patients. Illumina digital gene expression profiling was applied in two sample types - peripheral blood mononuclear cells (PBMCs) and synovial cells to compare the gene expression pattern between 17 patients with RA and three control groups (six osteoarthritis patients, three ankylosing spondylitis patients and 17 healthy controls). Bioinformatics was performed on pathway analysis and protein-protein interaction networks...
April 2, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28371471/promoter-polymorphisms-of-the-tim-4-gene-are-correlated-with-disease-activity-in-patients-with-systemic-lupus-erythematosus
#11
B Liu, W Liu, R Wang, Q Shu, X Zhang, X Fan, Q Zhang, X Liang, C Ma, L Gao
Although the TIM gene family plays important roles in immune responses, little is known about TIM regulation in the development of systemic lupus erythematosus (SLE). This study aimed to investigate the association of two TIM-4 single nucleotide polymorphisms (SNPs) rs6874202 (-1419G>A) and rs62382402 (-1609G>A) with SLE susceptibility in a Chinese Han population. The results showed no significant differences between patients with SLE and control group for rs6874202 and rs62382402 (p = .72, .53 respectively)...
March 31, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28371335/genetic-susceptibility-to-severe-asthma-with-fungal-sensitization
#12
N L Overton, A Simpson, P Bowyer, D W Denning
Severe asthma is problematic and its pathogenesis poorly understood. Fungal sensitization is common, and many patients with severe asthma with fungal sensitization (SAFS), used to denote this subgroup of asthma, respond to antifungal therapy. We have investigated 325 haplotype-tagging SNPs in 22 candidate genes previously associated with aspergillosis in patients with SAFS, with comparisons in atopic asthmatics and healthy control patients, of whom 47 SAFS, 279 healthy and 152 atopic asthmatic subjects were genotyped successfully...
March 31, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28371368/a-new-mica-allele-mica-007-07-characterized-by-cloning-and-sequencing
#13
W Y Wang, W Tian, F Wang, F M Zhu, P X Wang, L F Xing
A new MICA allelic variant, MICA*007:07, was identified in an individual of Mongol ethnicity in the Inner Mongolia Autonomous Region, northern China. Following polymerase chain reaction-sequence-based typing (PCR-SBT), this new allele was further confirmed by cloning and sequencing. MICA*007:07 differs from MICA*007:01 by a synonymous mutation from G to A at the 2nd nucleotide position in exon 2. MICA*007:07 was linked to HLA-B*27:05.
March 29, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28374504/polymorphisms-in-the-promoter-region-of-inos-predispose-to-rheumatoid-arthritis-in-south-indian-tamils
#14
V S Negi, C M Mariaselvam, D P Misra, N Muralidharan, C Fortier, D Charron, R Krishnamoorthy, R Tamouza
Nitric oxide synthase (NOS) catalyses the production of nitric oxide (NO) from L-Arginine, which participates in diverse biological processes including inflammation and apoptosis. Macrophages, chondrocytes, osteoblasts and osteoclasts express inducible NOS (iNOS) at the site of synovial inflammation. NO produced at the inflamed joint may contribute to peri-articular bone loss, mediate apoptosis and regulate Th1/Th2 balance in rheumatoid arthritis (RA). Variations in the promoter region of NOS gene regulate the nitric oxide synthase expression and iNOS (NOS2) polymorphisms have been associated with susceptibility to autoimmune disorders...
June 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28266165/il33-and-il1rl1-variants-are-associated-with-asthma-and-atopy-in-a-brazilian-population
#15
G A Queiroz, R S Costa, N M Alcantara-Neves, G Nunes de Oliveira Costa, M L Barreto, V L Carneiro, C A Figueiredo
Atopic asthma is a chronic inflammatory disease in airways resulting from genetic and environmental factors, characterized by production of the Th2 cytokines interleukin-4 (IL-4), interleukin-5 (IL-5) and interleukin-13 (IL-13). Interleukin-33 (IL-33) appears to be a potent inducer of Th2 immune response. This occurs when IL-33 binds and activates its receptor, the membrane ST2 (ST2L) in mast cells, dendritic cells, basophils, eosinophils, innate lymphoids and Th2 cells, leading to the release of these cytokines and intensifying allergic inflammation...
April 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28181414/a-functional-variant-of-mirna-149-confers-risk-for-allergic-rhinitis-and-comorbid-asthma-in-chinese-children
#16
D Hu, Z Zhang, X Ke, H Kang, S Hong
The prevalence of allergic rhinitis (AR) and asthma has been increasing, and the comorbidity rates of these diseases are very high. Here, 176 AR patients, 124 patients with comorbid AR and asthma (AR-A) and 206 healthy Chinese children as controls were included in a case-control study. Six single-nucleotide polymorphisms (SNPs), miR-146a (rs2910164, rs57095329 and rs6864584), miR-196a2 (rs11614913), miR-499 (rs3746444) and miR-149 (rs2292832), were genotyped. The prevalence of homozygous miR-149 (rs2292832) CC genotype and C allele were considerably increased in AR and AR-A patients, compared with the controls...
April 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28164472/the-il15-96522-a-t-functional-polymorphism-is-related-to-the-differentiation-of-th17-cells-and-the-severity-of-hashimoto-s-disease
#17
Y Arakawa, M Watanabe, K Takemura, N Inoue, Y Hidaka, Y Iwatani
To clarify the association between the genetic producibility of IL-15, a pro-inflammatory cytokine, and the pathogenesis of autoimmune thyroid diseases (AITDs), we genotyped +96522 A>T and +82889 A>G polymorphisms in the IL15 gene using 127 patients with Hashimoto's disease (HD), including 55 patients with severe HD and 48 patients with mild HD; 130 patients with Graves' disease (GD), including 52 patients with intractable GD and 44 patients with GD in remission; and 79 healthy volunteers. Both the IL15 +96522 A allele and AA genotype were more frequent in patients with severe HD than in those with mild HD...
April 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28185438/nomenclature-for-factors-of-the-hla-system-update-november-2016
#18
S G E Marsh
No abstract text is available yet for this article.
February 9, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28181407/nomenclature-for-factors-of-the-hla-system-update-october-2016
#19
S G E Marsh
No abstract text is available yet for this article.
February 8, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28176484/nomenclature-for-factors-of-the-hla-system-update-december-2016
#20
S G E Marsh
No abstract text is available yet for this article.
February 8, 2017: International Journal of Immunogenetics
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