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International Journal of Immunogenetics

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https://www.readbyqxmd.com/read/29756405/duplicated-major-histocompatibility-complex-class-ii-genes-in-the-tongue-sole-cynoglossus-semilaevis
#1
C Li, J Jiang, Q Zhang, X Wang
The major histocompatibility complex (MHC) molecule plays an important role in the vertebrate immune system. However, we have a limited understanding of the MHC genomic structure in teleosts. Using gene cloning and family analysis, we isolate the MHC class II genes in the tongue sole (Cynoglossus semilaevis) and find that both class II A and class II B genes are duplicated (named Cyse-DAA and Cyse-DBA, Cyse-DAB and Cyse-DBB, respectively). The class II A genes consist of four exons with a highly conserved genomic structure, but each gene has unique and defining exon 2 and intron 2 sequences...
May 13, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29726102/nomenclature-for-factors-of-the-hla-system-update-march-2018
#2
S G E Marsh
No abstract text is available yet for this article.
May 3, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29722202/nomenclature-for-factors-of-the-hla-system-update-january-2018
#3
S G E Marsh
No abstract text is available yet for this article.
May 2, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29722150/nomenclature-for-factors-of-the-hla-system-update-february-2018
#4
S G E Marsh
No abstract text is available yet for this article.
May 2, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29676515/characterization-of-a-novel-allelic-variant-in-hla-b-40-lineage-hla-b-40-298-02-by-cloning-and-sequencing
#5
W Tian, F M Zhu, W Y Wang, L X Li, J H Cai
A novel allelic variant in HLA-B*40 lineage, HLA-B*40:298:02, has been identified in an individual of Han ethnicity afflicted with nasopharyngeal carcinoma in Hunan province, southern China. Following polymerase chain reaction-Sanger sequence-based typing (PCR-SBT), this new variant was further confirmed by two distinct strategies of cloning and sequencing. HLA-B*40:298:02 differs from HLA-B*40:298:01 by a single synonymous cytosine substitution at nucleotide position 26 (T→C) in exon 3, which corresponds to codon 99 of the mature HLA-B mRNA molecule...
April 20, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29675993/effects-of-masp2-haplotypes-and-masp-2-levels-in-hepatitis-c-infected-patients
#6
Amanda A Silva, Sandra J Catarino, Angelica B W Boldt, Maria Lucia A Pedroso, Marcia H Beltrame, Iara J Messias-Reason
Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) are components of the lectin pathway, which activate the complement system after binding to the HCV structural proteins E1 and E2. We haplotyped 11 MASP2 polymorphisms in 103 HCV patients and 205 controls and measured MASP-2 levels in 67 HCV patients and 77 controls to better understand the role of MASP-2 in hepatitis C susceptibility and disease severity according to viral genotype and fibrosis levels. The haplotype block MASP2*ARDP was associated with protection against HCV infection (OR = 0...
April 19, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29675891/association-of-the-hla-b27-antigen-and-the-ctla4-gene-ct60-rs3087243-polymorphism-with-ankylosing-spondylitis-in-algerian-population-a-case-control-study
#7
C A Dahmani, A Benzaoui, H Amroun, F Mecabih, F Z Sediki, F Zemani-Fodil, M Fodil, W Boughrara, B Mecheti, N Attal, N Mehtar, E Petit-Teixeira, A Boudjema
Ankylosing spondylitis (AS) is a complex inflammatory disease that represents a major health problem both in Algeria and worldwide. Several lines of evidence support that genetic risk factors play a role in AS etiology and the CTLA4 gene has attracted a considerable attention. In this study, we were interested in evaluating the HLA-B27 frequency and in exploring the CTLA4 gene in a sample of the North African population. The dataset of the current study is composed of 81 patients with AS and 123 healthy controls...
April 19, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29667338/variation-in-the-tek-gene-is-not-associated-with-asthma-but-with-allergic-conjunctivitis
#8
L E Fodor, A Gézsi, Z Gál, A Nagy, A Kiss, A Bikov, C Szalai
The Tie2 receptor is an important player in angiogenesis. The Tie2 mRNA and protein are abundantly expressed in the lungs and the associated pathway also has an important role in the development and function of the eye. Tie2 is encoded by the TEK gene in humans. Recently, variations in the TEK gene have been found associated with asthma. The objective of the present study was to investigate whether variations in the TEK gene influenced the susceptibility to pediatric asthma and/or associated phenotypes like GINA status, viral- or exercise-induced asthma, allergic asthma, indoor, outdoor, inhalative allergies, IgE and eosonophil levels, allergic rhinitis and allergic conjunctivitis...
April 18, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29663681/two-novel-hla-c-alleles-hla-c-02-02-34-and-hla-c-03-369-were-identified-in-the-same-individual
#9
B Valatkaite-Rakstiene, R Cekauskiene, L Griskevicius, A Jakubauskas
Two new HLA class I alleles, HLA-C*02:02:34 and HLA-C*03:369, were characterized in a single Polish bone marrow donor.
April 16, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29663655/expression-of-hla-dqa1-and-hla-dqb1-genes-in-b-lymphocytes-monocytes-and-whole-blood
#10
M Zajacova, A Kotrbova-Kozak, M Cerna
Differential expression of HLA-DQA1 and HLA-DQB1 gene alleles was analysed in three different cell populations isolated from peripheral blood-B lymphocytes, monocytes and whole-blood cells. Interallelic differences in mRNA levels were observed: DQA1*03 alleles were among the most expressed in all cell types, whereas DQA1*05 alleles were least expressed in whole blood and monocytes and among the most expressed in B cells. For DQB1 gene, DQB1*06 group of alleles were the most expressed, and DQB1*02 group the least expressed within all cell populations examined...
April 16, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29575597/anti-hla-alloantibodies-of-the-iga-isotype-in-re-transplant-candidates-part-ii-correlation-with-graft-survival
#11
M-L Arnold, C Bach, F M Heinemann, P A Horn, M Ziemann, N Lachmann, A Mühlbacher, A Dick, A Ender, D Thammanichanond, S Schaub, G Hönger, G F Fischer, J Mytilineos, M Hallensleben, W E Hitzler, C Seidl, B M Spriewald
We reported previously on the widespread occurrence of anti-HLA alloantibodies of the IgA isotype (anti-HLA IgA) in the sera of solid-organ re-transplantation (re-tx) candidates (Arnold et al., ). Specifically focussing on kidney re-tx patients, we now extended our earlier findings by examining the impact of the presence and donor specificity of anti-HLA IgA on graft survival. We observed frequent concurrence of anti-HLA IgA and anti-HLA IgG in 27% of our multicenter collective of 694 kidney re-tx patients...
March 25, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29575524/distribution-of-ifitm3-polymorphism-dbsnp-rs12252-in-mestizo-populations-in-four-states-of-mexico
#12
J J López-Jiménez, D I Peña-Iñiguez, A L Fletes-Rayas, S E Flores-Martínez, J Sánchez-Corona, R C Rosales-Gomez, H Montoya-Fuentes
Interferon-inducible transmembrane protein 3 (IFITM3) participates in the defense against viral infections. This study identified and compared the frequency of the IFITM3 rs12252 polymorphism in 410 individuals in western Mexico. The western Mexican allelic frequencies (frequency of the "C" allele = 0.18) differ from some American, East Asian and European populations.
March 25, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29516629/genomic-sequences-of-hla-a-68-169-hla-b-07-298-and-hla-b-39-129
#13
A Balas, D Planelles, M Rodríguez-Cebriá, N Puig, J L Vicario
Three new HLA class I alleles were described in the Spanish population. HLA-A*68:169 and -B*39:129 show one amino acid replacement at the α1-domain, compared to A*68:02 (P47 > L47) and -B*39:06 (S11 > A11), respectively. HLA-B*07:298 presents one nucleotide mutation within exon 1, resulting in a new amino acid position -14, L>Q, which has not been previously described in any HLA protein. Prediction of the B*07:298 signal peptide cleavage did not show significant differences in comparison with that obtained for the rest of HLA-B genes...
March 8, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29464898/matching-donor-and-recipient-based-on-predicted-indirectly-recognizable-human-leucocyte-antigen-epitopes
#14
REVIEW
K Geneugelijk, E Spierings
The predicted indirectly recognizable human leucocyte antigen (HLA) epitopes (PIRCHE) algorithm is a novel in silico algorithm to determine donor-recipient compatibility. The PIRCHE algorithm determines donor-recipient compatibility by counting the number of mismatched HLA-derived epitopes that are involved in indirect T-cell alloimmune responses; these epitopes are designated as PIRCHE. Over the last few years, the PIRCHE algorithm has been investigated in both hematopoietic stem cell transplantation and solid organ transplantation...
April 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29441679/abo-and-rh-blood-group-genotypes-in-a-cohort-of-saudi-stem-cell-donors
#15
M Alzahrani, D Jawdat, A Alaskar, N Cereb, A H Hajeer
The ABO and rhesus (Rh) blood group antigens are the most frequently studied genetic markers in a large group of people. Blood type frequencies vary in different racial/ethnic groups. Our objective was to investigate the distribution of the ABO and rhesus (Rh) blood groups by molecular typing method in a population of Saudi stem cell donors. Our data indicate that the most common blood group in our population is group O followed by group A then group B, and finally, the least common is group AB.
April 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29431293/il-17a-g197g-association-between-no-x-and-gestational-age-in-a-south-african-birth-cohort
#16
P Nansook, R N Naidoo, S Muttoo, K Asharam, P Ramkaran, A Phulukdaree, A A Chuturgoon
Interleukin (IL-)17A, plays a role in pathogenic defence, but is implicated in chronic inflammatory diseases, and has recently been associated with variable pregnancy outcomes. We investigated the role of maternal IL-17-[G197A]-specific effects of third-trimester IL-17 mRNA expression, NOx exposure levels and other variables on gestational age, in the Mother and Child in the Environment (MACE) birth cohort in South Africa. A total of 327 participants were genotyped for IL-17-[G197A] by polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP)...
April 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29417746/nomenclature-for-factors-of-the-hla-system-update-november-2017
#17
S G E Marsh
No abstract text is available yet for this article.
April 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29405569/nomenclature-for-factors-of-the-hla-system-update-october-2017
#18
S G E Marsh
No abstract text is available yet for this article.
April 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29405566/nomenclature-for-factors-of-the-hla-system-update-december-2017
#19
S G E Marsh
No abstract text is available yet for this article.
April 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29227030/discrimination-of-fcgr2b-polymorphism-without-coamplification-of-fcgr2a-and-fcgr2c-genes
#20
F Bonatti, A Adorni, A Percesepe, D Martorana
The FCGR locus is characterized by high polymorphism and sequence homology. In particular, the Ile232Thr polymorphism in the FCGR2B gene results in inaccurate genotyping in most published papers. The purpose of the study was to develop an accurate genotyping assay able to discriminate this polymorphism.
February 2018: International Journal of Immunogenetics
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