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International Journal of Immunogenetics

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https://www.readbyqxmd.com/read/27870358/nomenclature-for-factors-of-the-hla-system-update-july-2016
#1
S G E Marsh
No abstract text is available yet for this article.
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27870357/nomenclature-for-factors-of-the-hla-system-update-september-2016
#2
S G E Marsh
No abstract text is available yet for this article.
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27870356/clinical-and-immunological-relevance-of-antibodies-in-solid-organ-transplantation
#3
REVIEW
N K Mehra, A K Baranwal
The two important issues affecting recipients of solid organ transplants and of importance to immunologists are (i) sensitization of the recipient to HLA antigens and the resultant humoral immune response leading to the development of anti-HLA antibodies; and ii) development of robust assays for early detection of humoral rejection post-transplant. Evidence from several studies clearly indicates that presence of circulating anti-HLA antibodies especially donor specific leads to early graft loss and high titres of DSA may even lead to hyperacute or accelerated acute rejection...
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27870355/impact-of-genomic-risk-factors-on-survival-after-haematopoietic-stem-cell-transplantation-for-patients-with-acute-leukaemia
#4
K F Pearce, Y Balavarca, J Norden, G Jackson, E Holler, R Dressel, H Greinix, A Toubert, E Gluckman, I Hromadnikova, P Sedlacek, D Wolff, U Holtick, H Bickeböller, A M Dickinson
The EBMT risk score is an established tool successfully used in the prognosis of survival post-HSCT and is applicable for a range of haematological disorders. One of its main advantages is that score generation involves summation of clinical parameters that are available pretransplant. However, the EBMT risk score is recognized as not being optimal. Previous analyses, involving patients with various diagnoses, have shown that non-HLA gene polymorphisms influence outcome after allogeneic HSCT. This study is novel as it focuses only on patients having acute leukaemia (N = 458) and attempts to demonstrate how non-HLA gene polymorphisms can be added to the EBMT risk score in a Cox regression model to improve prognostic ability for overall survival...
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27870354/nomenclature-for-factors-of-the-hla-system-update-august-2016
#5
S G E Marsh
No abstract text is available yet for this article.
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27774761/human-leucocyte-antigen-class-i-and-ii-imputation-in-a-multiracial-population
#6
M H Kuniholm, X Xie, K Anastos, X Xue, L Reimers, A L French, S J Gange, S G Kassaye, A Kovacs, T Wang, B E Aouizerat, H D Strickler
Human leucocyte antigen (HLA) genes play a central role in response to pathogens and in autoimmunity. Research to understand the effects of HLA genes on health has been limited because HLA genotyping protocols are labour intensive and expensive. Recently, algorithms to impute HLA genotype data using genome-wide association study (GWAS) data have been published. However, imputation accuracy for most of these algorithms was based primarily on training data sets of European ancestry individuals. We considered performance of two HLA-dedicated imputation algorithms - SNP2HLA and HIBAG - in a multiracial population of n = 1587 women with HLA genotyping data by gold standard methods...
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27774749/il-12b-and-il-10-gene-polymorphisms-in-the-development-of-hashimoto-s-thyroiditis
#7
J Gerenova, S Stanilova
Functional genetic polymorphisms that altered gene expression of cytokines are candidate genetic factors that could modulate the development and progression of Hashimoto's thyroiditis (HT). IL-12B gene encoded the IL-12p40 subunit, which is included in the pro-inflammatory heterodimeric cytokines IL-12p70 and IL-23. IL-10 is an important Treg cytokine suppressing inflammatory cytokine production and autoimmunity. This study was designed to compare -1082A/GIL-10 and +1188A/C3'UTRIL-12B genotype distribution in 130 patients with HT to a group of 157 healthy controls in attempts to determine an association with HT development...
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27753221/association-of-tumour-necrosis-factor-alpha-g-a-238-and-g-a-308-single-nucleotide-polymorphisms-with-juvenile-idiopathic-arthritis
#8
M Maddah, S Harsini, V Ziaee, M H Moradinejad, A Rezaei, S Zoghi, M Sadr, Y Aghighi, N Rezaei
Juvenile idiopathic arthritis (JIA) is a heterogeneous autoimmune disorder of unknown origin. As proinflammatory cytokines are known to contribute towards the pathogenesis of JIA, this case-control study was performed to examine the associations of certain single nucleotide polymorphisms (SNPs) of tumour necrosis factor-α (TNF-α) gene. Fifty-three patients with JIA participated in this study as patients group and compared with 137 healthy unrelated controls. Genotyping was performed for TNF-α gene at positions -308 and -238, using polymerase chain reaction with sequence-specific primers method...
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27682462/polymorphisms-in-toll-like-receptor-3-are-associated-with-asthma-related-phenotypes-in-the-chinese-han-patients
#9
Q Zhang, X L Fu, F H Qian, Q Cao, Z D Mao, J L Bai, Q Du, Y Shi
Toll-like receptor (TLR) 3 mediates antivirus immunity and is involved in asthma exacerbation and development. However, the genetic association between TLR3 and asthma remains unclear. This study aimed to evaluate the effects of polymorphisms within TLR3 on asthma risk and asthma-related phenotypes in the Chinese Han population. A total number of 462 unrelated adult patients with asthma and 398 healthy volunteers were enrolled in this study. The genotypes of tagging single nucleotide polymorphisms (SNPs) in TLR3 gene were determined using multiplex SNaPshot SNP genotyping assays...
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27528546/tumour-necrosis-factor-alpha-308g-a-promoter-polymorphism-is-associated-with-ulcerative-colitis-in-brazilian-patients
#10
M Tavares, C de Lima, W Fernandes, V Martinelli, M de Lucena, F Lima, A Telles, L Brandão, M de Melo Júnior
Inflammatory bowel disease consists of multifactorial diseases whose common manifestation is inflammation of the gastrointestinal tract and their pathogenesis remains unknown. This study aimed to analyse the gene polymorphisms in Brazilian patients with inflammatory bowel disease. A total of 101 patients diagnosed with inflammatory bowel disease were analysed for the tumour necrosis factor-alpha (-308 G/A; rs1800629) and interleukin-10 (-1082 G/A; rs1800896) gene polymorphisms. Genotyping was performed through polymerase chain reaction-sequence-specific primer, then fractionated on 2% agarose gel and visualized after staining by ethidium bromide...
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27553757/abstracts
#11
(no author information available yet)
No abstract text is available yet for this article.
October 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27519474/tnfsf4-polymorphisms-are-associated-with-systemic-lupus-erythematosus-in-the-malaysian-population
#12
K H Chua, Y Y Ooh, H C Chai
Tumour necrosis factor superfamily 4 (TNFSF4) gene has been reported to be associated with systemic lupus erythematosus (SLE) susceptibility due to its encoding for OX40L protein that can increase autoantibody production and cause imbalance of T-cell proliferation. The purpose of this study was to investigate the association of TNFSF4 rs2205960, rs1234315, rs8446748 and rs704840 with SLE in the Malaysian population. A total of 476 patients with SLE and 509 healthy controls were recruited. Real-time polymerase chain reaction (PCR) was applied to genotype the selected single nucleotide polymorphisms (SNPs)...
October 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27511726/hla-a-hla-b-and-hla-drb1-allele-and-haplotype-frequencies-of-10%C3%A2-918-koreans-from-bone-marrow-donor-registry-in-korea
#13
H Park, Y-J Lee, E Y Song, M H Park
The human leucocyte antigen (HLA) system is the most polymorphic genetic system in humans, and HLA matching is crucial in organ transplantation, especially in hematopoietic stem cell transplantation. We investigated HLA-A, HLA-B and HLA-DRB1 allele and haplotype frequencies at allelic level in 10 918 Koreans from bone marrow donor registry in Korea. Intermediate resolution HLA typing was performed using Luminex technology (Wakunaga, Japan), and additional allelic level typing was performed using PCR-single-strand conformation polymorphism method and/or sequence-based typing (Abbott Molecular, USA)...
October 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27511605/nomenclature-for-factors-of-the-hla-system-update-april-2016
#14
Steven G E Marsh
No abstract text is available yet for this article.
October 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27511361/nomenclature-for-factors-of-the-hla-system-update-may-2016
#15
Steven G E Marsh
No abstract text is available yet for this article.
October 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27507805/nomenclature-for-factors-of-the-hla-system-update-june-2016
#16
Steven G E Marsh
No abstract text is available yet for this article.
October 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27503599/bshi-guideline-hla-matching-and-donor-selection-for-haematopoietic-progenitor-cell-transplantation
#17
REVIEW
A-M Little, A Green, J Harvey, S Hemmatpour, K Latham, S G E Marsh, K Poulton, D Sage
A review of the British Society for Histocompatibility and Immunogenetics (BSHI) "Guideline for selection and HLA matching of related, adult unrelated donors and umbilical cord units for haematopoietic progenitor cell transplantation" was undertaken by a BSHI appointed writing committee. Literature searches were performed, and the data extracted were presented as recommendations according to the GRADE nomenclature.
October 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27484651/association-of-interleukin-16-polymorphisms-with-disease-progression-and-susceptibility-in-endometriosis
#18
P Azimzadeh, H R Khorram Khorshid, M M Akhondi, A Shirazi
Interleukin-16 (IL-16) is a multifunctional pro-inflammatory cytokine that was previously found in association with complex disorders, and it is now cleared that this cytokine plays a critical role in regulation of cellular functions such as homoeostasis. Due to the complexity of endometriosis and its resemblance to cancer, we designed present case-control study to determine the effects of genetic polymorphisms of the human IL-16 gene on Iranian women's susceptibility to endometriosis. A total of 126 patients with endometriosis (stages I-IV) and 144 healthy women as control group were recruited to the study...
October 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27320061/frequencies-of-red-blood-cell-major-blood-group-antigens-and-phenotypes-in-the-chinese-han-population-from-mainland-china
#19
Y Yu, C Ma, X Sun, X Guan, X Zhang, J Saldanha, L Chen, D Wang
Alloantibodies directed to red blood cell (RBC) antigens play an important role in alloimmune-mediated haemolytic transfusion reactions and haemolytic disease of the foetus and newborn. The frequencies and phenotypes of RBC antigens are different in populations from different geographic areas and races. However, the data on major blood group antigens in the Chinese Han population from Mainland China are still very limited; thus, we aimed to investigate them in this study. A total of 1412 unrelated voluntary Chinese Han blood donors were randomly recruited...
August 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27317472/polymorphism-in-the-chemokine-receptor-7-gene-ccr7-is-associated-with-previous-myocardial-infarction-in-patients-undergoing-elective-coronary-angiography
#20
P P Wołkow, L Drabik, J Totoń-Żurańska, K Kuś, J Foryś, A Słowik, J Pera, J Godlewski, M Tomala, K Żmudka, R Olszanecki, J Jawień, R Korbut
Coronary artery disease (CAD) remains a major cause of death in developed countries. Both environmental and, less known, genetic factors contribute to progression of CAD to myocardial infarction (MI). Immune system is activated in patients with CAD through dendritic cells (DCs), which present plaque antigens to T lymphocytes. Production of proinflammatory cytokines by activated T cells contributes to plaque rupture in MI. Chemokine receptor 7 (CCR7) on DCs is required for their chemotaxis from plaque to lymph nodes...
August 2016: International Journal of Immunogenetics
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