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International Journal of Immunogenetics

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https://www.readbyqxmd.com/read/28185438/nomenclature-for-factors-of-the-hla-system-update-november-2016
#1
S G E Marsh
No abstract text is available yet for this article.
February 9, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28181414/a-functional-variant-of-mirna-149-confers-risk-for-allergic-rhinitis-and-comorbid-asthma-in-chinese-children
#2
D Hu, Z Zhang, X Ke, H Kang, S Hong
The prevalence of allergic rhinitis (AR) and asthma has been increasing, and the comorbidity rates of these diseases are very high. Here, 176 AR patients, 124 patients with comorbid AR and asthma (AR-A) and 206 healthy Chinese children as controls were included in a case-control study. Six single-nucleotide polymorphisms (SNPs), miR-146a (rs2910164, rs57095329 and rs6864584), miR-196a2 (rs11614913), miR-499 (rs3746444) and miR-149 (rs2292832), were genotyped. The prevalence of homozygous miR-149 (rs2292832) CC genotype and C allele were considerably increased in AR and AR-A patients, compared with the controls...
February 8, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28181407/nomenclature-for-factors-of-the-hla-system-update-october-2016
#3
S G E Marsh
No abstract text is available yet for this article.
February 8, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28176484/nomenclature-for-factors-of-the-hla-system-update-december-2016
#4
S G E Marsh
No abstract text is available yet for this article.
February 8, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28164472/the-il15-96522-a-t-functional-polymorphism-is-related-to-the-differentiation-of-th17-cells-and-the-severity-of-hashimoto-s-disease
#5
Y Arakawa, M Watanabe, K Takemura, N Inoue, Y Hidaka, Y Iwatani
To clarify the association between the genetic producibility of IL-15, a pro-inflammatory cytokine, and the pathogenesis of autoimmune thyroid diseases (AITDs), we genotyped +96522 A>T and +82889 A>G polymorphisms in the IL15 gene using 127 patients with Hashimoto's disease (HD), including 55 patients with severe HD and 48 patients with mild HD; 130 patients with Graves' disease (GD), including 52 patients with intractable GD and 44 patients with GD in remission; and 79 healthy volunteers. Both the IL15 +96522 A allele and AA genotype were more frequent in patients with severe HD than in those with mild HD...
February 5, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28063209/exon-2-sequencing-of-the-new-hla-drb1-allele-drb1-13-216
#6
D Planelles, A Balas, R Alenda, J L Vicario
A novel HLA-DRB1*13:216 allele was characterized in a Spanish bone marrow donor.
January 6, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28044415/modulation-of-alloimmune-response-by-commensal-gut-microbiota-and-potential-new-avenues-to-influence-the-outcome-of-allogeneic-transplantation-by-modification-of-the-gut-culture
#7
REVIEW
S Kanangat
Host defence response against microbial infections was the foundation for the Science of Immunology. Now, we know the mechanisms of such host defence which include innate immune responses that is generally nonspecific but effective in many cases and lead to more specific responses called adaptive immune response. The gene loci of class I, II and III of the major histocompatibility complex (MHC) play a major role in directing the adaptive immune responses by presenting processed antigens to T and B cells to induce appropriate antigen-specific cellular and or humoral immune responses...
January 3, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28044416/identification-and-characterization-a-novel-hla-a-allele-a-02-355-by-sequence-based-typing-in-a-chinese-potential-donor
#8
X-M Nie, Y Zhang, W-B Qiao, C-F Zhu, Y-R Zhao
The new allele A*02:355 differs from A* 02:03:01 at positions 98 (T→A) and 102(A→C) resulting in an amino acid exchange F9→T. Interallelic sequence exchange is more likely the mechanism of its origination. The amino acid replacement influences the HLA peptide binding cleft and might have significant functional effects.
January 2, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28032448/hla-dqa1-and-hla-dqb1-allele-diversity-and-its-extended-haplotypes-in-madeira-island-portugal
#9
H Spínola, A Lemos, A R Couto, B Parreira, M Soares, I Dutra, J Bruges-Armas, A Brehm
This study shows, for the first time, high-resolution allele frequencies of HLA-DQA1 loci in Madeira Island (Portugal) and allows us to better understand and refine present knowledge on DQB1 variation, with the identification of several alleles not previously reported in this population. Estimates on haplotype profile, involving HLA-A, HLA-B, HLA-DRB1, HLA-DQA1 and HLA-DQB1, are also reported.
December 29, 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27987261/confirmation-and-next-generation-sequencing-of-allele-hla-b-35-279-found-in-a-family-of-a-leukaemia-patient-with-western-asia-origin
#10
F Grünebach, A-L Huster, W Vogel, R Klein
The confirmation of novel allele HLA-B*35:279 in a family of a leukaemia patient with Western Asia origin is reported. Moreover, next-generation sequencing (NGS) resulted in whole-gene sequence data and revealed the inheritance of HLA-B*35:279 on the paternal haplotype.
December 16, 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28092143/human-leucocyte-antigen-adverse-drug-reaction-associations-from-a-perspective-of-ethnicity
#11
REVIEW
G S Ghattaoraya, D Middleton, E J M Santos, R Dickson, A R Jones, A Alfirevic
Whilst immune-mediated adverse drug reactions (ADRs) are rare, they are potentially life-threatening and present a major problem for clinicians. The underlying mechanisms that cause ADRs are not fully understood although genomewide association studies (GWAS) and case-control investigations have associated human leucocyte antigen (HLA) alleles as risk factors. There is evidence that a patient's ethnic background can have an impact on their risk of developing an ADR. This review summarizes the evidence related to HLA alleles and ADRs with particular focus on patient ethnicity...
February 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27870358/nomenclature-for-factors-of-the-hla-system-update-july-2016
#12
S G E Marsh
No abstract text is available yet for this article.
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27870357/nomenclature-for-factors-of-the-hla-system-update-september-2016
#13
S G E Marsh
No abstract text is available yet for this article.
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27870356/clinical-and-immunological-relevance-of-antibodies-in-solid-organ-transplantation
#14
REVIEW
N K Mehra, A K Baranwal
The two important issues affecting recipients of solid organ transplants and of importance to immunologists are (i) sensitization of the recipient to HLA antigens and the resultant humoral immune response leading to the development of anti-HLA antibodies; and ii) development of robust assays for early detection of humoral rejection post-transplant. Evidence from several studies clearly indicates that presence of circulating anti-HLA antibodies especially donor specific leads to early graft loss and high titres of DSA may even lead to hyperacute or accelerated acute rejection...
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27870355/impact-of-genomic-risk-factors-on-survival-after-haematopoietic-stem-cell-transplantation-for-patients-with-acute-leukaemia
#15
K F Pearce, Y Balavarca, J Norden, G Jackson, E Holler, R Dressel, H Greinix, A Toubert, E Gluckman, I Hromadnikova, P Sedlacek, D Wolff, U Holtick, H Bickeböller, A M Dickinson
The EBMT risk score is an established tool successfully used in the prognosis of survival post-HSCT and is applicable for a range of haematological disorders. One of its main advantages is that score generation involves summation of clinical parameters that are available pretransplant. However, the EBMT risk score is recognized as not being optimal. Previous analyses, involving patients with various diagnoses, have shown that non-HLA gene polymorphisms influence outcome after allogeneic HSCT. This study is novel as it focuses only on patients having acute leukaemia (N = 458) and attempts to demonstrate how non-HLA gene polymorphisms can be added to the EBMT risk score in a Cox regression model to improve prognostic ability for overall survival...
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27870354/nomenclature-for-factors-of-the-hla-system-update-august-2016
#16
S G E Marsh
No abstract text is available yet for this article.
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27774761/human-leucocyte-antigen-class-i-and-ii-imputation-in-a-multiracial-population
#17
M H Kuniholm, X Xie, K Anastos, X Xue, L Reimers, A L French, S J Gange, S G Kassaye, A Kovacs, T Wang, B E Aouizerat, H D Strickler
Human leucocyte antigen (HLA) genes play a central role in response to pathogens and in autoimmunity. Research to understand the effects of HLA genes on health has been limited because HLA genotyping protocols are labour intensive and expensive. Recently, algorithms to impute HLA genotype data using genome-wide association study (GWAS) data have been published. However, imputation accuracy for most of these algorithms was based primarily on training data sets of European ancestry individuals. We considered performance of two HLA-dedicated imputation algorithms - SNP2HLA and HIBAG - in a multiracial population of n = 1587 women with HLA genotyping data by gold standard methods...
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27774749/il-12b-and-il-10-gene-polymorphisms-in-the-development-of-hashimoto-s-thyroiditis
#18
J Gerenova, S Stanilova
Functional genetic polymorphisms that altered gene expression of cytokines are candidate genetic factors that could modulate the development and progression of Hashimoto's thyroiditis (HT). IL-12B gene encoded the IL-12p40 subunit, which is included in the pro-inflammatory heterodimeric cytokines IL-12p70 and IL-23. IL-10 is an important Treg cytokine suppressing inflammatory cytokine production and autoimmunity. This study was designed to compare -1082A/GIL-10 and +1188A/C3'UTRIL-12B genotype distribution in 130 patients with HT to a group of 157 healthy controls in attempts to determine an association with HT development...
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27753221/association-of-tumour-necrosis-factor-alpha-g-a-238-and-g-a-308-single-nucleotide-polymorphisms-with-juvenile-idiopathic-arthritis
#19
M Maddah, S Harsini, V Ziaee, M H Moradinejad, A Rezaei, S Zoghi, M Sadr, Y Aghighi, N Rezaei
Juvenile idiopathic arthritis (JIA) is a heterogeneous autoimmune disorder of unknown origin. As proinflammatory cytokines are known to contribute towards the pathogenesis of JIA, this case-control study was performed to examine the associations of certain single nucleotide polymorphisms (SNPs) of tumour necrosis factor-α (TNF-α) gene. Fifty-three patients with JIA participated in this study as patients group and compared with 137 healthy unrelated controls. Genotyping was performed for TNF-α gene at positions -308 and -238, using polymerase chain reaction with sequence-specific primers method...
December 2016: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/27682462/polymorphisms-in-toll-like-receptor-3-are-associated-with-asthma-related-phenotypes-in-the-chinese-han-patients
#20
Q Zhang, X L Fu, F H Qian, Q Cao, Z D Mao, J L Bai, Q Du, Y Shi
Toll-like receptor (TLR) 3 mediates antivirus immunity and is involved in asthma exacerbation and development. However, the genetic association between TLR3 and asthma remains unclear. This study aimed to evaluate the effects of polymorphisms within TLR3 on asthma risk and asthma-related phenotypes in the Chinese Han population. A total number of 462 unrelated adult patients with asthma and 398 healthy volunteers were enrolled in this study. The genotypes of tagging single nucleotide polymorphisms (SNPs) in TLR3 gene were determined using multiplex SNaPshot SNP genotyping assays...
December 2016: International Journal of Immunogenetics
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