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International Journal of Immunogenetics

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https://www.readbyqxmd.com/read/30188011/hla-profile-of-the-donors-in-the-macedonian-bone-marrow-donor-registry
#1
Meri Kirijas, Sonja Genadieva Stavrik, Dejan Trajkov, Slavica Hristomanova Mitkovska, Aleksandar Senev, Olivija Efinska Mladenovska, Olgica Sibinovska, Aleksandar Petlichkovski
The importance of HLA alleles in the process of haematopoietic stem cell transplantation, especially the process of unrelated donor search, is enormous. Macedonian Bone Marrow Donor Registry was established in 2010 and has registered volunteer donors from different nationalities that live in the Republic of Macedonia. The aim of this study was to determine the HLA allele and haplotype frequencies of the volunteer donors from the Macedonian Bone Marrow Donor Registry and to compare this results with the Macedonians from a family study...
September 6, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/30117674/characterization-of-three-new-hla-class-i-alleles-in-chinese-individuals-hla-b-46-68-b-46-71-b-46-72
#2
Wei Wang, Nanying Chen, Lina Dong, Yanmin He, Sudan Tao, Wei Zhang, Ji He, Jiangtian Chen, Faming Zhu
Three new HLA class I alleles were described in the Chinese population. HLA-B*46:68,-B*46:71,-B*46:72 alleles differ from HLA-B*46:01:01 by a single nucleotide substitution at position 485C>T, 484A>G, 299T>A respectively.
August 17, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/30091527/nomenclature-for-factors-of-the-hla-system-update-may-2018
#3
Steven G E Marsh
No abstract text is available yet for this article.
August 9, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/30074682/nomenclature-for-factors-of-the-hla-system-update-june-2018
#4
Steven G E Marsh
No abstract text is available yet for this article.
August 3, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/30070777/nomenclature-for-factors-of-the-hla-system-update-april-2018
#5
Steven G E Marsh
No abstract text is available yet for this article.
August 2, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/30063114/characterization-of-a-novel-allelic-variant-in-hla-b-46-01-lineage-hla-b-46-01-25-by-cloning-phasing-and-sequencing
#6
LiXin Li, Wei Tian, FaMing Zhu, WenYi Wang, Fan Wang
A new allelic variant in HLA-B*46:01 lineage, HLA-B*46:01:25, has been identified in a male individual of Mongol ethnicity residing in northern China. Following polymerase chain reaction-sequence-based typing (PCR-SBT), this novel variant was further confirmed by cloning, phasing and sequencing. HLA-B*46:01:25 differs from HLA-B*46:01:01 by a single synonymous T substitution at nucleotide position 137 (C - T) in exon 4, corresponding to codon 228 (ACC-ACT) of the mature HLA-B mRNA molecule.
July 31, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/30051604/hla-b-gene-somatic-insertion-deletion-mutations-in-patients-with-acute-myelogenous-leukaemia
#7
Nikola Königova, Ivana Skoumalova, Jana Onderkova, Zuzana Ambruzova, Tomas Szotkowski, Zdenek Koristek, Alena Maluskova, Ludek Raida, Frantisek Mrazek
Loss of heterozygosity is considered to be the most common type of tumour-specific somatic mutation of the human leucocyte antigens (HLA) genes in patients with haematological malignancies. Nevertheless, subtle DNA sequence changes, namely short insertions/deletions, may also abolish the expression of HLA molecules and interfere with routine HLA typing. Two male patients with acute myelogenous leukaemia (AML) were indicated for the search of a suitable donor for allogeneic haematopoietic stem cell transplantation (aHSCT)...
July 27, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/30043490/the-influence-of-glucocorticoid-receptor-single-nucleotide-polymorphisms-on-outcome-after-haematopoietic-stem-cell-transplantation
#8
Jean Norden, Kim F Pearce, Julie A E Irving, Matthew P Collin, Xiao N Wang, Daniel Wolff, Hans-Jochem Kolb, Gerard Socie, Zoya Kuzmina, Hildegard Greinix, Ernst Holler, Vanderson Rocha, Eliane Gluckman, Ilona Hromadnikova, Anne M Dickinson
Haematopoietic stem cell transplantation (HSCT) remains the only cure for most haematological malignancies, however, the mortality rate remains high. Complications after HSCT include relapse, graft versus host disease (GvHD), graft rejection and infection. Over the last few years several groups, have demonstrated that non-HLA gene polymorphisms can be predictive of outcome after HSCT. Since the glucocorticoid cortisol is pivotal in the regulation of the immune system, we decided to examine single nucleotide polymorphisms (SNPs; rs6198, rs33388 and rs33389) within the glucocorticoid receptor (GR) and correlate with HSCT outcome...
July 25, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/30030939/human-leucocyte-antigen-g-14-bp-indel-polymorphism-and-oral-squamous-cell-carcinoma-risk-in-chinese-han-population-a-case-control-study
#9
Zengqi Wang, Lina Zhao, Lina Liu, Xueying Liu
Human leucocyte antigen-G (HLA-G) is a nonclassical HLA class I molecule involved in tumour immune escape. The purpose of this study was to investigate the association between the 14-bp insertion/deletion (InDel) polymorphism in the 3' untranslated region (3'-UTR) of HLA-G gene and oral squamous cell carcinoma (OSCC) risk in Chinese Han population (216 cases and 193 healthy controls), and furthermore, to evaluate serum soluble HLA-G (sHLA-G) levels in the OSCC patients. Our results demonstrated that the Ins allele was significantly less frequent in the OSCC patients than that in the healthy controls (odds ratio [OR] = 0...
July 21, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/30009568/tnfrsf1a-polymorphisms-and-their-role-in-multiple-sclerosis-susceptibility-and-severity-in-the-slovak-population
#10
Juraj Javor, Ivana Shawkatová, Vladimíra Ďurmanová, Zuzana Párnická, Daniel Čierny, Jozef Michalik, Daniela Čopíková-Cudráková, Barbora Smahová, Karin Gmitterová, Ľubica Peterajová, Mária Bucová
Tumour necrosis factor (TNF)-mediated signalling plays a key role in inflammatory and neurodegenerative processes leading to the development of multiple sclerosis (MS). Recent studies have highlighted the role of tumour necrosis factor receptor superfamily member 1A (TNFRSF1A) gene encoding the type 1 TNF receptor in the genetic predisposition to MS. This study aimed to validate the association of TNFRSF1A rs1800693 and rs4149584 polymorphisms with susceptibility to MS in the Slovak population and analyse their influence on age at disease onset, severity, and disability progression...
July 16, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/30009514/current-strategies-exploiting-nk-cell-therapy-to-treat-haematologic-malignancies
#11
REVIEW
Jenna K Johnson, Jeffrey S Miller
Natural killer (NK) cells recognize targets that have been changed via malignant transformation or infection. Previously, NK cells were thought to be short-lived, but we now know that NK cells can be long-lived and remember past exposures in response to CMV. NK cells use a plethora of activating and inhibitory receptors to recognize these changes and attack targets, but tumour cells often evade NK cells. Therefore, major efforts are being made to hone in on NK cell antitumour properties in immunotherapy. In the clinical setting, haploidentical NK cells can be adoptively transferred to help treat cancer...
July 16, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29908012/allelic-and-haplotype-diversity-of-hla-a-hla-b-and-hla-drb1-gene-at-high-resolution-in-the-nanning-han-population
#12
YongFeng Pei, HuiNi Huang, HengCong Li, JieRun Chen, GuoGuang Wu
The distribution of human leucocyte antigen (HLA) allele and haplotype varied among different ethnic populations. In this study, we investigated the allele and haplotype frequencies of HLA-A, HLA-B and HLA-DRB1 loci in the Nanning Han population who live in Guangxi province of China. We identified 26 HLA-A, 56 HLA-B and 31 HLA-DRB1 alleles in 562 Nanning individuals of Han ethnic group by sequence-based typing method. Of these, the three most common alleles in HLA-A, HLA-B and HLA-DRB1 loci, respectively, were A*11:01 (32...
August 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29869432/evaluation-of-ion-torrent-sequencing-technology-for-rapid-clinical-human-leucocyte-antigen-typing
#13
Sandra G Guerra, Winnie Chong, Colin J Brown, Cristina V Navarrete
The development of techniques to define the human leucocyte antigen (HLA) region has proven to be challenging due to its high level of polymorphism. Within a clinical laboratory, a technique for high-resolution HLA typing, which is rapid and cost effective is essential. NGS has provided a rapid, high-resolution HLA typing solution, which has reduced the number of HLA ambiguities seen with other typing methods. In this study, the One Lambda NXType NGS kit was tested on the Ion Torrent PGM platform. A total of 362 registry donors from four ethnic populations (Europeans, South Asians, Africans and Chinese) were NGS HLA typed across 9-loci (HLA-A, -B, -C, -DRB1,-DRB345 -DQB1 and -DPB1)...
August 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29863307/association-of-cd14-and-macrophage-migration-inhibitory-factor-gene-polymorphisms-with-inflammatory-micrornas-expression-levels-in-ankylosing-spondylitis-and-polyarthralgia
#14
S K Vishwakarma, C Lakkireddy, G Sravani, B V S Sastry, N Raju, S I Ahmed, A A Khan, N Owaisi, A Jaisawal, M A Khan, A A Khan
This study aimed to investigate the genetic basis of ankylosing spondylitis (AS) and polyarthralgia (PA) conditions among Indian subjects through genotyping two immune regulatory genes CD14 (-159C>T) and MIF (-173G>C) and find their association with the expression levels of three circulating inflammatory miRNAs. This investigation may provide early genetic cause of these two forms of arthritis and more optimal biological targets to predict early therapeutic outcomes. A total of 140 patients (AS: 70 and PA: 70) and 156 controls were recruited from Indian population...
August 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29799674/utility-of-next-generation-sequencing-methods-to-identify-the-novel-hla-alleles-in-potential-stem-cell-donors-from-chinese-marrow-donor-program
#15
Jun Qi, Tian-Ju Wang, Li-Ping Chen, Xiao-Fang Wang, Man-Ni Wang, Jun-Hua Wu
The human leucocyte antigen (HLA) is the most polymorphic region of the human genome. Compared with Sanger-sequencing-based typing (SBT) methods, next-generation sequencing (NGS) has significantly higher throughput and depth sequencing characteristics, having dramatic impacts on HLA typing in clinical settings. Here, we performed NGS technology with Ion Torrent S5 platform to evaluate the potential four novel HLA alleles detected in five donors from Chinese Marrow Donor Program (CMDP, Shaanxi Province) during routine Sanger SBT testing...
August 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29797531/hla-g-regulatory-variants-and-haplotypes-with-susceptibility-to-recurrent-pregnancy-loss
#16
N Yazdani, M Shekari Khaniani, M Bastami, T Ghasemnejad, F Afkhami, S Mansoori Derakhshan
HLA-G is a nonclassical Class I major histocompatibility complex (MHC) gene. This gene has a limited protein alteration that is produced by alternative splicing and can be important in the preservation of pregnancy. Recent findings suggest that alteration in HLA-G gene expression can lead to pregnancy failure, such as recurrent pregnancy loss (RPL). As the promoter SNPs of the gene may impact the HLA-G expression levels, the study of these SNPs is very important. In this study, for the promoter region of HLA-G gene in the case group (100 women with a history of two or more repeated miscarriages) and the control group (100 women with at least two successful pregnancies), PCR reaction was performed...
August 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29756405/duplicated-major-histocompatibility-complex-class-ii-genes-in-the-tongue-sole-cynoglossus-semilaevis
#17
C Li, J Jiang, Q Zhang, X Wang
The major histocompatibility complex (MHC) molecule plays an important role in the vertebrate immune system. However, we have a limited understanding of the MHC genomic structure in teleosts. Using gene cloning and family analysis, we isolate the MHC class II genes in the tongue sole (Cynoglossus semilaevis) and find that both class II A and class II B genes are duplicated (named Cyse-DAA and Cyse-DBA, Cyse-DAB and Cyse-DBB, respectively). The class II A genes consist of four exons with a highly conserved genomic structure, but each gene has unique and defining exon 2 and intron 2 sequences...
August 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29726102/nomenclature-for-factors-of-the-hla-system-update-march-2018
#18
S G E Marsh
No abstract text is available yet for this article.
June 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29722202/nomenclature-for-factors-of-the-hla-system-update-january-2018
#19
S G E Marsh
No abstract text is available yet for this article.
June 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29722150/nomenclature-for-factors-of-the-hla-system-update-february-2018
#20
S G E Marsh
No abstract text is available yet for this article.
June 2018: International Journal of Immunogenetics
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