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Journal of Inflammation

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https://www.readbyqxmd.com/read/28100959/hydrogen-rich-saline-attenuates-eosinophil-activation-in-a-guinea-pig-model-of-allergic-rhinitis-via-reducing-oxidative-stress
#1
Shaoqing Yu, Chuanliang Zhao, Na Che, Lin Jing, Rongming Ge
BACKGROUND: It is well considered that reactive oxygen species (ROS) plays a prominent causative role in the development of allergic rhinitis (AR), and eosinophils cells as important allergic inflammatory cells contribute to elevating oxidative stress. Hydrogen, emerging as a novel antioxidant, has been proven effective in selectively reducing ROS in animals models of oxidative damage. We herein aim to verify protective effects of hydrogen on eosinophils cells in guinea pigs models of AR...
2017: Journal of Inflammation
https://www.readbyqxmd.com/read/27990099/cardiovascular-diseases-related-gnb3-c825t-polymorphism-has-a-significant-sex-specific-effect-on-serum-soluble-e-selectin-levels
#2
Kokoè Mélinda Gbadoe, Nazha Berdouzi, Alex-Ander Aldasoro Aguiñano, Ndeye Coumba Ndiaye, Sophie Visvikis-Siest
BACKGROUND: The C825T polymorphism (rs5443) of the Guanine Nucleotide-Binding protein subunit β3 (GNB3) gene has been associated with obesity, essential hypertension, atherosclerosis, coronary diseases, and cerebrovascular events, but with some sex-specific effects. Its association with inflammatory mediators such as cell adhesion molecules has not been studied, although they are heavily involved in cardiovascular diseases' (CVDs) processes. The aim of our study was then to investigate a possible sex-specific effect of the GNB3 C825T polymorphism on serum soluble cell adhesion molecules such as E, P and L-selectins (sE, sP and sL-selectins)...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27980459/increased-adipose-tissue-expression-of-tlr8-in-obese-individuals-with-or-without-type-2-diabetes-significance-in-metabolic-inflammation
#3
Rasheed Ahmad, Shihab Kochumon, Reeby Thomas, Valerie Atizado, Sardar Sindhu
BACKGROUND: The innate immune Toll-like receptors (TLRs) 2/4 are important players in chronic low-grade inflammation called metabolic inflammation in obesity and type-2 diabetes (T2D). While TLR2/4 expression changes associated with metabolic inflammation are known, the adipose tissue expression of endocytic TLR8, which is expressed by all major macrophage subsets, remain unclear. We, therefore, determined the TLR8 mRNA/protein expression in the adipose tissue samples from lean, overweight, and obese individuals with or without T2D...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27980458/ethyl-pyruvate-is-a-novel-anti-inflammatory-agent-to-treat-multiple-inflammatory-organ-injuries
#4
REVIEW
Runkuan Yang, Shengtao Zhu, Tor Inge Tonnessen
Ethyl pyruvate (EP) is a simple derivative of pyruvic acid, which is an important endogenous metabolite that can scavenge reactive oxygen species (ROS). Treatment with EP is able to ameliorate systemic inflammation and multiple organ dysfunctions in multiple animal models, such as acute pancreatitis, alcoholic liver injury, acute respiratory distress syndrome (ARDS), acute viral myocarditis, acute kidney injury and sepsis. Recent studies have demonstrated that prolonged treatment with EP can ameliorate experimental ulcerative colitis and slow multiple tumor growth...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27932936/riboflavin-along-with-antibiotics-balances-reactive-oxygen-species-and-inflammatory-cytokines-and-controls-staphylococcus-aureus-infection-by-boosting-murine-macrophage-function-and-regulates-inflammation
#5
Somrita Dey, Biswadev Bishayi
BACKGROUND: Macrophages serve as intracellular reservoirs of S. aureus. Recent in vitro studies have confirmed high level resistance by S. aureus to macrophage mediated killing and the intracellular persistence of Staphylococci may play an important role in the pathogenesis. Since this localization protects them from both cell-mediated and humoral immune responses, therefore, a successful anti-staphylococcal therapy should include the elimination of intracellular bacteria, further protecting the host cells from staphylococci-induced cell death...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27924136/prognostic-value-of-inflammation-in-prostate-cancer-progression-and-response-to-therapeutic-a-critical-review
#6
REVIEW
Alessandro Sciarra, Alessandro Gentilucci, Stefano Salciccia, Federico Pierella, Flavio Del Bianco, Vincenzo Gentile, Ida Silvestri, Susanna Cattarino
Prostate is an immune-competent organ normally populated by inflammatory cells. Prostatic inflammation origin can be multi-factorial and there are some emerging evidences on its possible role as a factor involved in prostate cancer (PC) pathogenesis and progression. This review critically analyzes the role of inflammation as a prognostic factor for progression and aggressiveness of PC. We verified the last 10 years literature data on the association between inflammation and PC aggressiveness, or PC response to therapies...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27904436/effects-of-metformin-on-blood-and-urine-pro-inflammatory-mediators-in-patients-with-type-2-diabetes
#7
Wei Chen, Xiaojie Liu, Shandong Ye
BACKGROUND: Metformin has been used for the treatment of type 2 diabetes by suppressing hepatic gluconeogenesis. It has been shown that the subclinical inflammatory responses play important roles in the pathogenesis of type 2 diabetes. In the present study, we determined the effects of metformin on the levels of pro-inflammatory cytokines (i.e., IL-6, TNF-α, and MCP-1) and anti-inflammatory mediator IL-10 in blood and urine of patients with type 2 diabetes. There were 210 patients with type 2 diabetes, which were randomized into metformin (n = 112) and non-metformin (gliclazide, acarbose, and repaglinide, n = 98) groups...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27807399/electric-stimulation-of-the-vagus-nerve-reduced-mouse-neuroinflammation-induced-by-lipopolysaccharide
#8
G Meneses, M Bautista, A Florentino, G Díaz, G Acero, H Besedovsky, D Meneses, A Fleury, A Del Rey, G Gevorkian, G Fragoso, E Sciutto
BACKGROUND: Neuroinflammation (NI) is a key feature in the pathogenesis and progression of infectious and non-infectious neuropathologies, and its amelioration usually improves the patient outcome. Peripheral inflammation may promote NI through microglia and astrocytes activation, an increased expression of inflammatory mediators and vascular permeability that may lead to neurodegeneration. Several anti-inflammatory strategies have been proposed to control peripheral inflammation. Among them, electrical stimulation of the vagus nerve (VNS) recently emerged as an alternative to effectively attenuate peripheral inflammation in a variety of pathological conditions with few side effects...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27795695/circulating-chemokine-ligand-levels-before-and-after-successful-kidney-transplantation
#9
Hamdi Elmoselhi, Holly Mansell, Mahmoud Soliman, Ahmed Shoker
BACKGROUND: Chemokine ligands (CCLs) play a pivotal role in tissue injury before and after kidney transplantation. Meanwhile, transplantation improves patient's survival and diminishes morbidity. It is hypothesized, then, that kidney transplantation diminishes pre-transplant (pre-TX) levels of circulating inflammatory CCLs. This retrospective study compared circulating levels and profiles of CCLs before transplantation (pre-TX) and after transplantation (post-TX). METHODS: Nineteen CCLs (1, 2, 3, 4, 5, 8, 11, 13, 15, 17, 21, 24, 26, 27, CXCL 5, 8, 10, 12 and 13) were measured in 47 stable post-TX recipients, and their stored pre-TX plasma was analyzed by multiplexed fluorescent bead-based immunoassay...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27625590/chondroprotective-effect-of-high-molecular-weight-hyaluronic-acid-on-osteoarthritic-chondrocytes-in-a-co-cultivation-inflammation-model-with-m1-macrophages
#10
Christoph Bauer, Eugenia Niculescu-Morzsa, Vivek Jeyakumar, Daniela Kern, Stephan S Späth, Stefan Nehrer
BACKGROUND: Osteoarthritis (OA) is described by an imbalance between anabolic and catabolic processes in the affected joint. This dysregulation of metabolism affects not only chondrocytes within cartilage tissue but also the cells of the synovial membrane across the border of the joint. An important factor in OA is the low viscosity of the synovial fluid. High-molecular-weight hyaluronic acid (HA) can be used to increase the viscosity and also reduce inflammatory processes. The purpose was to establish an in vitro inflammation model and to evaluate the effects of high-molecular-weight HA in a co-cultivation inflammation model of osteoarthritic chondrocytes and M1 macrophages...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27601939/circulating-adipokine-levels-and-prognostic-value-in-septic-patients
#11
Andreas Hillenbrand, Pengfei Xu, Shaoxia Zhou, Annette Blatz, Manfred Weiss, Sebastian Hafner, Doris Henne-Bruns, Uwe Knippschild
BACKGROUND: Adipokines have a wide range of effects and are linked to sepsis and septic shock. The aim of the present study was to describe the changes in adipokine levels in septic patients in relation to patients' preseptic adipokine levels. Furthermore, we examined adipokines as prognostic markers. METHODS: Fourteen consecutive critically ill patients meeting the clinical criteria for severe sepsis or septic shock 3 days up to 1 month after major visceral surgery were enrolled prospectively...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27563282/acidification-changes-affect-the-inflammasome-in-human-nucleus-pulposus-cells
#12
Frank J Brand, Mahtab Forouzandeh, Harmanpreet Kaur, Francesco Travascio, Juan Pablo de Rivero Vaccari
BACKGROUND: Interleukin (IL)-1β is involved in the pathology of intervertebral disc degeneration. Under normal conditions, IL-1β is present in cells in an inactive form (pro-IL-1β). However, under pathological conditions, pro-IL-1β is turned into its active form (IL-1β) by the inflammasome, a multi-protein complex of the innate immune response that activates caspase-1. Under conditions of degeneration, the disc experiences an environment of increased acidification. However, the implications of acidification on the innate immune response remain poorly explored...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27555804/monocyte-chemoattractant-protein-1-is-not-required-for-liver-regeneration-after-partial-hepatectomy
#13
Stephanie L Wyler, Shawna L D'Ingillo, Cheri L Lamb, Kristen A Mitchell
BACKGROUND: Liver regeneration following 70 % partial hepatectomy (PH) requires the coordinated expression of soluble mediators produced by macrophages. Monocyte chemoattractant protein-1 (MCP-1) is a potent stimulus of monocyte recruitment and macrophage activation. The goal of this study was to determine how MCP-1 contributes to liver regeneration. METHODS: PH was performed on anesthetized C57Bl/6 (wild type) and MCP-1 knockout mice, and macrophage-produced cytokines and hepatocyte proliferation were measured...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27547125/peroxisome-proliferator-activated-receptor-ppar-%C3%AE-and-%C3%AE-activators-induce-icam-1-expression-in-quiescent-non-stimulated-endothelial-cells
#14
Julia Naidenow, Igor Hrgovic, Monika Doll, Tsige Hailemariam-Jahn, Victoria Lang, Johannes Kleemann, Stefan Kippenberger, Roland Kaufmann, Nadja Zöller, Markus Meissner
BACKGROUND: Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that are implicated in the regulation of lipid and glucose homeostasis. PPAR agonists have been shown to control inflammatory processes, in part by inhibiting the expression of distinct proinflammatory genes such as vascular cell adhesion molecule-1 (VCAM-1), IL-8, and intercellular adhesion molecule-1 (ICAM-1). ICAM-1 is an important endothelial membrane receptor that facilitates the transmigration of leukocytes across the endothelium...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27493587/nasal-inflammation-and-its-response-to-local-glucocorticoid-regular-treatment-in-patients-with-persistent-non-allergic-rhinitis-a-pilot-study
#15
Donatella Poletti, Valeria Iannini, Paolo Casolari, Marco Contoli, Alberto Papi, Paul Kirkham, Trevor T Hansel, Kian Fan Chung, Peter J Barnes, Antonio Pastore, Stefano Pelucchi, Ian M Adcock, Gaetano Caramori
BACKGROUND: The pathogenesis of non-allergic rhinitis (NAR) is still largely unknown. Furthermore, it is unclear whether there is a correlation between the effect of nasal glucocorticoids on nasal inflammation and on nasal symptoms and quality of life. METHODS: In this pilot study we recruited 12 healthy subjects and 24 patients with recently diagnosed persistent NAR [12 untreated and 12 under regular treatment with nasal fluticasone furoate (two sprays of 27.5 μg each in each nostril once daily, total daily dose = 110 μg) for at least 20 days]...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27486384/apolipoprotein-a-i-gene-transfer-exerts-immunomodulatory-effects-and-reduces-vascular-inflammation-and-fibrosis-in-ob-ob-mice
#16
Frank Spillmann, Bart De Geest, Ilayaraja Muthuramu, Ruhul Amin, Kapka Miteva, Burkert Pieske, Carsten Tschöpe, Sophie Van Linthout
BACKGROUND: Obesity is associated with vascular inflammation, fibrosis and reduced high-density lipoproteins (HDL)-cholesterol. We aimed to investigate whether adenoviral gene transfer with human apolipoprotein (apo) A-I (Ad.A-I), the main apo of HDL, could exert immunomodulatory effects and counteract vascular inflammation and fibrosis in ob/ob mice. METHODS: Ad.A-I transfer was performed in 8 weeks (w) old ob/ob mice, which were sacrificed 7 w later. The aorta was excised for mRNA analysis and the spleen for splenocyte isolation for subsequent flow cytometry and co-culture with murine fibroblasts...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27478413/a-comparative-study-of-blood-endotoxin-detection-in-haemodialysis-patients
#17
Jonathan Wong, Nathan Davies, Hasan Jeraj, Enric Vilar, Adie Viljoen, Ken Farrington
BACKGROUND: Endotoxemia is commonly reported in patients receiving haemodialysis and implicated in the pathogenesis of systemic inflammation. The Limulus Amoebocyte Lysate (LAL) assay is the most commonly used blood endotoxin detection assay. Two kinetic variations of the assay are commercially available - the turbidimetric and chromogenic assay, it is unknown which assay is superior for endotoxin detection in uremic patients. Selection of the optimum LAL technique for endotoxin detection in haemodialysis patients is important to further understanding of the sequela of endotoxemia and development of endotoxin-lowering strategies in this population...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27478412/phenotypic-analysis-of-peripheral-b-cell-populations-during-mycobacterium-tuberculosis-infection-and-disease
#18
Willem J du Plessis, Alana Keyser, Gerhard Walzl, André G Loxton
BACKGROUND: Mycobacterium tuberculosis (Mtb) remains an unresolved threat resulting in great annual loss of life. The role of B cells during the protective immunity to Mtb is still unclear. B cells have been described as effector cells in addition to their role as antibody producing cells during disease. Here we aim to identify and characterize the frequency of peripheral B-cell subpopulations during active Tuberculosis and over treatment response. Analysis were done for both class switched (CS) and non-class switched (NCS) phenotypes...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27441030/micrornas-differentially-expressed-in-beh%C3%A3-et-disease-are-involved-in-interleukin-6-production
#19
Min-Yeong Woo, Su Jin Yun, Okki Cho, Kyongmin Kim, Eun-So Lee, Sun Park
BACKGROUND: Behcet's disease (BD) is characterized by systemic recurrent inflammation with increased production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 by peripheral blood mononuclear cells (PBMCs). To gain insight into the underlying mechanisms of this disease, the expression levels of distinct microRNAs in PBMCs of BD patients were determined and their association with TNF-α and IL-6 production was evaluated. FINDINGS: The expression levels of microRNAs, miR-638 and miR-4488, were reduced in patients with stable BD in comparison with healthy controls...
2016: Journal of Inflammation
https://www.readbyqxmd.com/read/27418880/abnormal-cannabidiol-attenuates-experimental-colitis-in-mice-promotes-wound-healing-and-inhibits-neutrophil-recruitment
#20
Regina M Krohn, Sean A Parsons, Jakub Fichna, Kamala D Patel, Robin M Yates, Keith A Sharkey, Martin A Storr
BACKGROUND: Non-psychotropic atypical cannabinoids have therapeutic potential in a variety of inflammatory conditions including those of the gastrointestinal tract. Here we examined the effects of the atypical cannabinoid abnormal cannabidiol (Abn-CBD) on wound healing, inflammatory cell recruitment and colitis in mice. METHODS: Colitis was induced in CD1 mice by a single intrarectal administration of trinitrobenzene sulfonic acid (TNBS, 4 mg/100 μl in 30 % ethanol) and Abn-CBD and/or the antagonists O-1918 (Abd-CBD), AM251 (CB1 receptor) and AM630 (CB2 receptor), were administered intraperitoneally (all 5 mg/kg, twice daily for 3 days)...
2016: Journal of Inflammation
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