journal
MENU ▼
Read by QxMD icon Read
search

Alzheimer's & Dementia: the Journal of the Alzheimer's Association

journal
https://www.readbyqxmd.com/read/28624335/neuropathologic-features-of-tomm40-523-variant-on-late-life-cognitive-decline
#1
Lei Yu, Michael W Lutz, Jose M Farfel, Robert S Wilson, Daniel K Burns, Ann M Saunders, Philip L De Jager, Lisa L Barnes, Julie A Schneider, David A Bennett
INTRODUCTION: The study investigated the role of neuropathologies in the relationship between TOMM40 '523 genotype and late-life cognitive decline. METHODS: Participants were community-dwelling older persons who had annual cognitive assessments and brain autopsies after death. Genotyping used DNA from peripheral blood or postmortem brain tissue. Linear mixed models assessed the extent to which the association of '523 genotype with cognitive decline is attributable to neuropathologies...
June 15, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28624149/brain-function-and-structure-and-risk-for-incident-diabetes-the-atherosclerosis-risk-in-communities-study
#2
Michael P Bancks, Alvaro Alonso, Rebecca F Gottesman, Thomas H Mosley, Elizabeth Selvin, James S Pankow
INTRODUCTION: Diabetes is prospectively associated with cognitive decline. Whether lower cognitive function and worse brain structure are prospectively associated with incident diabetes is unclear. METHODS: We analyzed data for 10,133 individuals with cognitive function testing (1990-1992) and 1212 individuals with brain magnetic resonance imaging (1993-1994) from the Atherosclerosis Risk in Communities cohort. We estimated hazard ratios for incident diabetes through 2014 after adjustment for traditional diabetes risk factors and cohort attrition...
June 14, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28623677/incidence-of-cognitively-defined-late-onset-alzheimer-s-dementia-subgroups-from-a-prospective-cohort-study
#3
Paul K Crane, Emily Trittschuh, Shubhabrata Mukherjee, Andrew J Saykin, R Elizabeth Sanders, Eric B Larson, Susan M McCurry, Wayne McCormick, James D Bowen, Thomas Grabowski, Mackenzie Moore, Julianna Bauman, Alden L Gross, C Dirk Keene, Thomas E Bird, Laura E Gibbons, Jesse Mez
INTRODUCTION: There may be biologically relevant heterogeneity within typical late-onset Alzheimer's dementia. METHODS: We analyzed cognitive data from people with incident late-onset Alzheimer's dementia from a prospective cohort study. We determined individual averages across memory, visuospatial functioning, language, and executive functioning. We identified domains with substantial impairments relative to that average. We compared demographic, neuropathology, and genetic findings across groups defined by relative impairments...
June 14, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28627380/post-traumatic-stress-disorder-and-risk-of-dementia-among-members-of-a-health-care-delivery-system
#4
Jason D Flatt, Paola Gilsanz, Charles P Quesenberry, Kathleen B Albers, Rachel A Whitmer
INTRODUCTION: Post-traumatic stress disorder (PTSD) is associated with an increased risk of dementia in male veterans, but little is known in females and civilians. METHODS: PTSD and comorbidities were abstracted from medical records from 1/1/1996 to 12/31/2001. Dementia incidence from 1/1/2002 to 12/31/2014 in 499,844 health care members aged 60+ years over an average of 8.2 years. Cox proportional hazard models were adjusted for age, demographics, and comorbidities...
June 13, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28627379/microvascular-changes-in-down-syndrome-with-alzheimer-type-pathology-insights-into-a-potential-vascular-mechanism-for-down-syndrome-and-alzheimer-s-disease
#5
David A Drachman, Thomas W Smith, Bassam Alkamachi, Kevin Kane
INTRODUCTION: The mechanism triggering degeneration in Alzheimer's disease (AD) remains uncertain. Therapeutic failure following β amyloid (Aβ) removal casts doubt on amyloid neurotoxicity per se as the primary cause of AD. Impaired microvascular function has been suggested as an alternative etiology. People with Down syndrome (DS) develop Alzheimer pathology, but whether microvascular impairment also occurs in DS (as in AD) is unknown. METHODS: We examined brain microvasculature in five DS subjects with AD-type histopathology, seven AD cases, and seven controls without AD-type pathology...
June 13, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28627378/practical-risk-score-for-5-10-and-20-year-prediction-of-dementia-in%C3%A2-elderly-persons-framingham-heart-study
#6
Jinlei Li, Matthew Ogrodnik, Sherral Devine, Sanford Auerbach, Philip A Wolf, Rhoda Au
INTRODUCTION: With a rapidly aging population, general practitioners are confronting the challenge of how to determine those who are at greatest risk for dementia and potentially need more specialized follow-up to mitigate symptoms early in its course. We created a practical dementia risk score and provided individualized estimates of future dementia risk. METHODS: Using the Framingham Heart Study data, we built our prediction model using Cox proportional hazard models and developed a point system for the risk score and risk estimates...
June 13, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28602601/association-of-amine-biomarkers-with-incident-dementia-and-alzheimer-s-disease-in-the-framingham-study
#7
Vincent Chouraki, Sarah R Preis, Qiong Yang, Alexa Beiser, Shuo Li, Martin G Larson, Galit Weinstein, Thomas J Wang, Robert E Gerszten, Ramachandran S Vasan, Sudha Seshadri
INTRODUCTION: The identification of novel biomarkers associated with Alzheimer's disease (AD) could provide key biological insights and permit targeted preclinical prevention. We investigated circulating metabolites associated with incident dementia and AD using metabolomics. METHODS: Plasma levels of 217 metabolites were assessed in 2067 dementia-free Framingham Offspring Cohort participants (mean age = 55.9 ± 9.7 years; 52.4% women). We studied their associations with future dementia and AD risk in multivariate Cox models...
June 8, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28599121/head-or-brain-injuries-and-alzheimer-s-disease-a-nested-case-control-register-study
#8
Anna-Maija Tolppanen, Heidi Taipale, Sirpa Hartikainen
INTRODUCTION: Many previous studies have been limited by self- or proxy-reported injury or short follow-up. We investigated whether head or brain injuries are associated with Alzheimer's disease (AD), possible modifying factors and dose-response relationship. METHODS: Nested register-based case-control study of all community dwellers who received clinically verified AD diagnosis in Finland in 2005 to 2011 (n = 70,719) and one to four matched controls for each case (n of controls = 282,862)...
June 6, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28586648/objective-features-of-subjective-cognitive-decline-in-a-us-national-database
#9
Stephanie Kielb, Emily Rogalski, Sandra Weintraub, Alfred Rademaker
INTRODUCTION: Functional and cognitive features of subjective cognitive decline (SCD) were identified in a longitudinal database from the National Alzheimer Coordinating Center. METHODS: Cognitively normal older adults with (SCD+) and without (SCD-) self-reported memory complaints (N = 3915) were compared on (1) baseline Functional Assessment Questionnaire ratings, (2) baseline scores and longitudinal rate of change estimates from nine neuropsychological tests, and (3) final clinical diagnoses...
June 3, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28579315/dementia-prevalence-care-arrangement-and-access-to-care-in-lebanon
#10
Kieu T T Phung, Monique Chaaya, Martin Prince, Samir Atweh, Khalil El Asmar, Georges Karam, Rose Mary Khoury, Lilian Ghandour, Husam Ghusn, Rune T Nielsen, Gunhild Waldemar
INTRODUCTION: In North Africa and the Middle East, studies about dementia prevalence are scarce. The Arabic-validated 10/66 Dementia Research Group diagnostic assessment was used to assess the prevalence of dementia in Lebanon in a population-based study. The study also examined care arrangement and access to care. METHODS: A random sample of 502 persons older than 65 years and their informant were recruited from Beirut and Mount Lebanon governorates through multistage cluster sampling...
June 1, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28576507/dementia-registries-around-the-globe-and-their-applications-a-systematic-review
#11
REVIEW
Karolina Krysinska, Perminder S Sachdev, John Breitner, Miia Kivipelto, Walter Kukull, Henry Brodaty
Patient registries are valuable tools helping to address significant challenges in research, care, and policy. Registries, well embedded in many fields of medicine and public health, are relatively new in dementia. This systematic review presents the current situation in regards to dementia registries worldwide. We identified 31 dementia registries operating on an international, national, or local level between 1986 and 2016. More than half of the registries aimed to conduct or facilitate research, including preclinical research registries and registries recruiting research volunteers...
May 30, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28531379/the-association-between-an-inflammatory-diet-and-global-cognitive-function-and-incident-dementia-in-older-women-the-women-s-health-initiative-memory-study
#12
Kathleen M Hayden, Daniel P Beavers, Susan E Steck, James R Hebert, Fred K Tabung, Nitin Shivappa, Ramon Casanova, JoAnn E Manson, Claudia B Padula, Elena Salmoirago-Blotcher, Linda G Snetselaar, Oleg Zaslavsky, Stephen R Rapp
INTRODUCTION: The Mediterranean and Dietary Approaches to Stop Hypertension diets have been associated with lower dementia risk. We evaluated dietary inflammatory potential in relation to mild cognitive impairment (MCI)/dementia risk. METHODS: Baseline food frequency questionnaires from n = 7085 women (aged 65-79 years) were used to calculate Dietary Inflammatory Index (DII) scores that were categorized into four groups. Cognitive function was evaluated annually, and MCI and all-cause dementia cases were adjudicated centrally...
May 19, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28531378/cognitive-ability-in-young-adulthood-and-risk-of-dementia-in-a-cohort-of-danish-men-brothers-and-twins
#13
Merete Osler, Gunhild T Christensen, Ellen Garde, Erik L Mortensen, Kaare Christensen
INTRODUCTION: We examined the association between cognitive ability in young adulthood and dementia in Danish men, brothers, and male twins. METHODS: In total, 666,986 men born between 1939 and 1959 were identified for dementia diagnosis in national registries from 1969 to 2016. The association between cognitive ability from draft board examination and dementia was examined using Cox regression. RESULTS: During a 44-year follow-up, 6416 (0...
May 19, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28528849/extracellular-low-n-oligomers-of-tau-cause-selective-synaptotoxicity-without-affecting-cell-viability
#14
Senthilvelrajan Kaniyappan, Ram Reddy Chandupatla, Eva-Maria Mandelkow, Eckhard Mandelkow
INTRODUCTION: Tau-mediated toxicity in Alzheimer's disease is thought to operate through low-n oligomers, rather than filamentous aggregates. However, the nature of oligomers and pathways of toxicity are poorly understood. Therefore, we investigated structural and functional aspects of highly purified oligomers of a pro-aggregant tau species. METHODS: Purified oligomers of the tau repeat domain were characterized by biophysical and structural methods. Functional aspects were investigated by cellular assays ((3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium) bromide assay of cell viability, lactate dehydrogenase release assay [for cell toxicity], reactive oxygen species production, and calcium assay), combined with analysis of neuronal dendritic spines exposed to oligomers...
May 18, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28501451/habitual-exercise-levels-are-associated-with-cerebral-amyloid-load-in-presymptomatic-autosomal-dominant-alzheimer-s-disease
#15
Belinda M Brown, Hamid R Sohrabi, Kevin Taddei, Samantha L Gardener, Stephanie R Rainey-Smith, Jeremiah J Peiffer, Chengjie Xiong, Anne M Fagan, Tammie Benzinger, Virginia Buckles, Kirk I Erickson, Roger Clarnette, Tejal Shah, Colin L Masters, Michael Weiner, Nigel Cairns, Martin Rossor, Neill R Graff-Radford, Stephen Salloway, Jonathan Vöglein, Christoph Laske, James Noble, Peter R Schofield, Randall J Bateman, John C Morris, Ralph N Martins
INTRODUCTION: The objective of this study was to evaluate the relationship between self-reported exercise levels and Alzheimer's disease (AD) biomarkers, in a cohort of autosomal dominant AD mutation carriers. METHODS: In 139 presymptomatic mutation carriers from the Dominantly Inherited Alzheimer Network, the relationship between self-reported exercise levels and brain amyloid load, cerebrospinal fluid (CSF) Aβ42, and CSF tau levels was evaluated using linear regression...
May 11, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28549947/family-history-and-tomm40-523-interactive-associations-with-memory-in-middle-aged-and-alzheimer-s-disease-cohorts
#16
Auriel A Willette, Joseph L Webb, Michael W Lutz, Barbara B Bendlin, Alexandra M Wennberg, Jennifer M Oh, Allen Roses, Rebecca L Koscik, Bruce P Hermann, N Maritza Dowling, Sanjay Asthana, Sterling C Johnson
INTRODUCTION: Family history (FH) of Alzheimer's disease (AD) affects mitochondrial function and may modulate effects of translocase of the outer mitochondrial membrane 40 kDa (TOMM40) rs10524523 ('523) poly-T length on memory decline. METHODS: For 912 nonapolipoprotein ε4 middle-aged adults and 365 aged adults across the AD spectrum, linear mixed models gauged FH and TOMM40 '523 interactions on memory and global cognition between baseline and up to 10 years later...
May 10, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28522216/associations-of-lower-vitamin-d-concentrations-with-cognitive-decline-and-long-term-risk-of-dementia-and-alzheimer-s-disease-in-older-adults
#17
Catherine Feart, Catherine Helmer, Bénédicte Merle, François R Herrmann, Cédric Annweiler, Jean-François Dartigues, Cécile Delcourt, Cécilia Samieri
INTRODUCTION: Hypovitaminosis D has been associated with several chronic conditions; yet, its association with cognitive decline and the risk of dementia and Alzheimer's disease (AD) has been inconsistent. METHODS: The study population consisted of 916 participants from the Three-City Bordeaux cohort aged 65+, nondemented at baseline, with assessment of vitamin D status and who were followed for up to 12 years. RESULTS: In multivariate analysis, compared with individuals with 25(OH)D sufficiency (n = 151), participants with 25(OH)D deficiency (n = 218) exhibited a faster cognitive decline...
May 9, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28475854/peripheral-complement-interactions-with-amyloid-%C3%AE-peptide-erythrocyte-clearance-mechanisms
#18
William D Brubaker, Andrés Crane, Jenny U Johansson, Kevin Yen, Kristina Garfinkel, Diego Mastroeni, Priya Asok, Bonnie Bradt, Marwan Sabbagh, Tanya L Wallace, Courtney Glavis-Bloom, Andrea J Tenner, Joseph Rogers
INTRODUCTION: Although amyloid β peptide (Aβ) is cleared from the brain to cerebrospinal fluid and the peripheral circulation, mechanisms for its removal from blood remain unresolved. Primates have uniquely evolved a highly effective peripheral clearance mechanism for pathogens, immune adherence, in which erythrocyte complement receptor 1 (CR1) plays a major role. METHODS: Multidisciplinary methods were used to demonstrate immune adherence capture of Aβ by erythrocytes and its deficiency in Alzheimer's disease (AD)...
May 2, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28463681/cerebral-amyloid-angiopathy-in-down-syndrome-and-sporadic-and-autosomal-dominant-alzheimer-s-disease
#19
María Carmona-Iragui, Mircea Balasa, Bessy Benejam, Daniel Alcolea, Susana Fernández, Laura Videla, Isabel Sala, María Belén Sánchez-Saudinós, Estrella Morenas-Rodriguez, Roser Ribosa-Nogué, Ignacio Illán-Gala, Sofía Gonzalez-Ortiz, Jordi Clarimón, Frederick Schmitt, David K Powell, Beatriz Bosch, Albert Lladó, Michael S Rafii, Elizabeth Head, José Luis Molinuevo, Rafael Blesa, Sebastián Videla, Alberto Lleó, Raquel Sánchez-Valle, Juan Fortea
INTRODUCTION: We aimed to investigate if cerebral amyloid angiopathy (CAA) is more frequent in genetically determined than in sporadic early-onset forms of Alzheimer's disease (AD) (early-onset AD [EOAD]). METHODS: Neuroimaging features of CAA, apolipoprotein (APOE), and cerebrospinal fluid amyloid β (Aβ) 40 levels were studied in subjects with Down syndrome (DS, n = 117), autosomal-dominant AD (ADAD, n = 29), sporadic EOAD (n = 42), and healthy controls (n = 68)...
April 29, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28438508/comments-on-the-nexus-meeting-report-regarding-dementia-and-cancer
#20
LETTER
Ronald R Louie
No abstract text is available yet for this article.
April 21, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
journal
journal
40839
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"