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Heart Failure Clinics

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https://www.readbyqxmd.com/read/29966644/erratum
#1
(no author information available yet)
No abstract text is available yet for this article.
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966643/the-right-heart-international-network-right-net-a-road-map-through-the-right-heart-pulmonary-circulation-unit
#2
EDITORIAL
Eduardo Bossone, Luna Gargani
No abstract text is available yet for this article.
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966642/right-heart-catheterization-for-the-diagnosis-of-pulmonary-hypertension-controversies-and-practical-issues
#3
REVIEW
Michele D'Alto, Konstantinos Dimopoulos, John Gerard Coghlan, Gabor Kovacs, Stephan Rosenkranz, Robert Naeije
Right heart catheterization (RHC) is the gold standard for the diagnosis and classification of pulmonary hypertension. Significant expertise is required for safely performing a full RHC and for the acquisition of reliable and reproducible information. Physicians performing an RHC should have adequate training not only in vascular access, catheter insertion, and manipulation but also in the interpretation of waveforms, potential pitfalls, and strict quality control. This article describes the essential technical aspects of RHC as applied to the pulmonary circulation, the potential pitfalls, and areas of major controversy...
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966641/the-right-heart-international-network-right-net-rationale-objectives-methodology-and-clinical-implications
#4
REVIEW
Francesco Ferrara, Luna Gargani, William F Armstrong, Gergely Agoston, Antonio Cittadini, Rodolfo Citro, Michele D'Alto, Antonello D'Andrea, Santo Dellegrottaglie, Nicola De Luca, Giovanni Di Salvo, Stefano Ghio, Ekkehard Grünig, Marco Guazzi, Jaroslaw D Kasprzak, Theodore John Kolias, Gabor Kovacs, Patrizio Lancellotti, Andrè La Gerche, Giuseppe Limongelli, Alberto Maria Marra, Antonella Moreo, Ellen Ostenfeld, Francesco Pieri, Lorenza Pratali, Lawrence G Rudski, Rajan Saggar, Rajeev Saggar, Marco Scalese, Christine Selton-Suty, Walter Serra, Anna Agnese Stanziola, Damien Voilliot, Olga Vriz, Robert Naeije, Eduardo Bossone
The Right Heart International Network is a multicenter international study aiming to prospectively collect exercise Doppler echocardiography tests of the right heart pulmonary circulation unit (RHPCU) in large cohorts of healthy subjects, elite athletes, and individuals at risk of or with overt pulmonary hypertension. It is going to provide standardization of exercise stress echocardiography of RHPCU and explore the full physiopathologic response.
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966640/the-right-heart-pulmonary-circulation-unit-and-left-heart-valve-disease
#5
REVIEW
Laura Filippetti, Damien Voilliot, Michele Bellino, Rodolfo Citro, Yun Yun Go, Patrizio Lancellotti
Valvular heart disease (VHD) is frequently accompanied by pulmonary hypertension (PH). In asymptomatic patients, PH is rare, although the exact prevalence is unknown and mainly stems from the severity of the VHD and the presence of diastolic dysfunction. PH can also be depicted during exercise echocardiography. PH either at rest or during exercise is also a powerful determinant of outcome and is independently associated with reduced survival, regardless of the severity of the underlying valvular pathology. Therefore, because PH is a marker of poor prognosis, assessment of PH in VHD is crucial for risk stratification and management of patients with VHD...
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966639/exercise-training-and-rehabilitation-in-pulmonary-hypertension
#6
REVIEW
Nicola Benjamin, Alberto Maria Marra, Christina Eichstaedt, Ekkehard Grünig
Within the last years, exercise training and rehabilitation as add-on to medical treatment has become an emerging field in pulmonary hypertension. Owing to the beneficial effects of exercise training in pulmonary hypertension, the new European Respiratory Society/European Society of Cardiology guidelines for pulmonary hypertension recommended a supervised and closely monitored exercise and respiratory training/rehabilitation as add-on to medical therapy (class IIa, level of evidence B). In this article, different training modalities, effects of exercise training, possible pathobiological mechanisms of action, and future research questions are discussed...
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966638/chronic-right-heart-failure-expanding-prevalence-and-challenges-in-outpatient-management
#7
REVIEW
Mwelwa Chizinga, Wassim H Fares
Right heart failure is caused by right heart dysfunction resulting in suboptimal stroke volume to supply the pulmonary circulation. Therapeutic developments mean that patients with acute right heart failure survive to hospital discharge and live with chronic right heart failure. Chronic right heart failure management aims to reduce afterload, optimize preload, and support contractility, with the best evidence available in vascular targeted therapy for pulmonary arterial hypertension. However, the management of chronic right heart failure relies on adapting therapies for left ventricular heart failure to the right...
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966637/pulmonary-hypertension-related-to-chronic-obstructive-pulmonary-disease-and-diffuse-parenchymal-lung-disease-a-focus-on-right-ventricular-dys-function
#8
REVIEW
Steve Tseng, Anna Agnese Stanziola, Samir Sultan, Kyle Henry, Rajeev Saggar, Rajan Saggar
Diffuse pulmonary lung disease and chronic obstructive pulmonary disease is a heterogeneous population that can manifest pulmonary hypertension. These subgroups are classified as primarily World Health Organization group 3. Available data suggest that the impact of pulmonary hypertension targeted therapy in diffuse pulmonary lung disease and chronic obstructive pulmonary disease is limited and survival is poor despite attempted treatment.
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966636/biomarkers-in-pulmonary-hypertension
#9
REVIEW
Alberto Maria Marra, Eduardo Bossone, Andrea Salzano, Roberta D'Assante, Federica Monaco, Francesco Ferrara, Michele Arcopinto, Olga Vriz, Toru Suzuki, Antonio Cittadini
Biomarkers are tools in pulmonary hypertension (PH) management. They may address risk assessment, disease progression, response to medical and surgical therapy, risk of right heart failure, and prognosis. The activation of molecular pathways is the pathophysiological underpinning of the biomarkers assessed in peripheral venous blood. A multiparametric approach, involving different biomarkers, is preferred because it provides relevant clinical information regarding different organs and body systems. This is especially true in the final stages of PH with its comorbidities and different pathophysiological patterns, supporting that PH is a systemic condition rather than an isolated cardiorespiratory illness...
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966635/imaging-the-right-heart-pulmonary-circulation-unit-the-role-of-mri-and-computed-tomography
#10
REVIEW
Santo Dellegrottaglie, Ellen Ostenfeld, Javier Sanz, Alessandra Scatteia, Pasquale Perrone-Filardi, Eduardo Bossone
The different components of the right heart pulmonary circulation unit can be investigated by MRI and computed tomography. MRI has clear advantages over echocardiography for accurate definition of right heart function and structure and to derive functional information regarding the pulmonary vasculature. Computed tomography is superior for the assessment of parenchymal and vascular pathologies of the lung with indications in the diagnostic work-up of pulmonary hypertension, but with more limited capability to evaluate right ventricular function and in deriving pulmonary hemodynamics...
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966634/imaging-the-right-heart-pulmonary-circulation-unit-the-role-of-ultrasound
#11
REVIEW
Jaroslaw D Kasprzak, Olivier Huttin, Karina Wierzbowska-Drabik, Christine Selton-Suty
Echocardiography is the first step in imaging the right heart pulmonary circulation unit (RH-PCU), and the only one to allow its complete morphologic, functional, and hemodynamic analysis in all clinical scenarios. Right ventricular (RV) function is not only the consequence of its intrinsic contractile function (morphology and contractility) but also highly dependent on preload, afterload, and ventricular interdependence. Comprehensive echocardiographic examination of RH-PCU allows insight into intrinsic and extrinsic factors of RV function...
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966633/invasive-and-noninvasive-evaluation-for-the-diagnosis-of-pulmonary-hypertension-how-to-use-and-how-to-combine-them
#12
REVIEW
Michele D'Alto, Giovanni Maria Di Marco, Antonello D'Andrea, Paola Argiento, Emanuele Romeo, Francesco Ferrara, Bouchra Lamia, Stefano Ghio, Lawrence G Rudski
The etiologic diagnosis of pulmonary hypertension (PH) may be very challenging. Right-heart catheterization (RHC) in isolation cannot classify a precapillary PH patient into group 1, 3, 4, or 5. Moreover, RHC may be not sufficient for reaching a definitive differential diagnosis of precapillary or postcapillary PH if hemodynamic data are not integrated in clinical context and combined with information gleaned from noninvasive imaging. Therefore, only the integration of risk factors, clinical evaluation, invasive and noninvasive tests allows the physician to distinguish between different forms of PH...
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966632/chronic-thromboembolic-pulmonary-hypertension
#13
REVIEW
Christopher J Mullin, James R Klinger
Chronic thromboembolic pulmonary hypertension (CTEPH) is a distinct type of pulmonary hypertensive disease, characterized by incomplete or abnormal resolution of acute pulmonary embolism such that residual emboli become organized and fibrotic. CTEPH can occur in patients without a prior history of venous thromboembolism, and is diagnosed based on precapillary pulmonary hypertension on right heart catheterization with evidence of chronic emboli on ventilation/perfusion scan, chest imaging, or pulmonary angiogram...
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966631/right-heart-pulmonary-circulation-at-high-altitude-and-the-development-of-subclinical-pulmonary-interstitial-edema
#14
REVIEW
Lorenza Pratali
Most healthy subjects can develop a subclinical interstitial pulmonary edema that is a complex and multifactor phenomenon, still with unanswered questions, and might be one line of defense against the development of severe symptomatic lung edema. Whether the acute, reversible increase in lung fluid content is really an innocent and benign part of the adaptation to extreme physiologic condition or rather the clinically relevant marker of an individual vulnerability to life-threatening high altitude pulmonary edema remains to be established in future studies...
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966630/pulmonary-hypertension-the-role-of-lung-transplantation
#15
REVIEW
Samir Sultan, Steve Tseng, Anna Agnese Stanziola, Tony Hodges, Rajan Saggar, Rajeev Saggar
Despite advances in targeted medical therapy, pulmonary arterial hypertension (PAH) remains a fatal disease because of progressive right ventricular dysfunction. For patients who are refractory to medical therapy, heart-lung and lung transplantation are important treatment options. Because of longer waiting time, surgical interventions including extracorporeal lung support and atrial septostomy can be used in PAH patients bridging to transplantation.
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966629/right-heart-pulmonary-circulation-unit-in-cardiomyopathies-and-storage-diseases
#16
REVIEW
Antonello D'Andrea, Tiziana Formisano, Andrè La Gerche, Nuno Cardim, Andreina Carbone, Raffaella Scarafile, Francesca Martone, Michele D'Alto, Eduardo Bossone, Maurizio Galderisi
Cardiomyopathies (CM) are a heterogeneous group of muscle heart diseases, divided into 3 main categories (dilated, hypertrophic, and restrictive). In addition to these subgroups, athlete's heart and hypertensive cardiopathy are both the result of heart adaptation to increased loading conditions, making it possible to include them in the CM group. Right heart involvement is clear in some CM as arrhythmogenic CM, carcinoid syndrome, and endomyocardial fibrosis, whereas in others, like hypertrophic or dilated CM, it is known that the right heart has a prognostic impact but less clear is its pathogenic role...
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966628/pulmonary-hypertension-and-heart-failure-a-dangerous-liaison
#17
REVIEW
Marco Guazzi
Pulmonary hypertension (PH) is a common hemodynamic evolution of heart failure (HF) with preserved or reduced ejection fraction, responsible for congestion, symptoms worsening, exercise limitation, and negative outcome. In HF of any origin, PH develops in response to a passive backward pressure transmission as result of increased left atrial pressure. Sustained pressure injury and chronic venous congestion can trigger pulmonary vasoconstriction and vascular remodeling, leading to irreversible pulmonary vascular disease, right ventricular hypertrophy, and failure...
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966627/right-heart-pulmonary-circulation-unit-in-congenital-heart-diseases
#18
REVIEW
Inga Voges, Mouaz H Al-Mallah, Giancarlo Scognamiglio, Giovanni Di Salvo
The right ventricle plays a major role in congenital heart disease. This article describes the right ventricular mechanics in some selected congenital heart diseases affecting the right ventricle in different ways: tetralogy of Fallot, Ebstein anomaly, and the systemic right ventricle.
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966626/pulmonary-circulation-on-the-crossroads-between-the-left-and-right-heart-in-systemic-sclerosis-a-clinical-challenge-for-cardiologists-and-rheumatologists
#19
REVIEW
Luna Gargani, Damien Voilliot, Michele D'Alto, Gergely Agoston, Antonella Moreo, Walter Serra, Francesco Pieri, Fabio Mori, Karina Wierzbowska-Drabik, Marco Matucci-Cerinic, Alberto Moggi-Pignone
Involvement of the right heart-pulmonary circulation system in systemic sclerosis is a typical feature, with critical prognostic implications. Pulmonary hypertension may occur in association with interstitial lung disease or as a result of an isolated pulmonary vascular disease that may affect both the precapillary arterioles and the postcapillary venules, as well as a consequence of left heart involvement. These apparently different phenotypes often underlie a significant pathophysiologic overlap, which makes the diagnosis and management of these patients highly complex and uncertain...
July 2018: Heart Failure Clinics
https://www.readbyqxmd.com/read/29966625/pulmonary-arterial-hypertension
#20
REVIEW
Mark W Dodson, Lynette M Brown, Charles Gregory Elliott
This article provides an overview of pulmonary arterial hypertension (PAH), beginning with the initial pathologic recognition of pulmonary hypertension more than 100 years ago and progressing to the current diagnostic categorization of PAH. It reviews the epidemiology, pathophysiology, genetics, and modern treatment of PAH. The article discusses several important recent studies that have highlighted the importance of new management strategies, including serial risk assessment and combination pharmacotherapy...
July 2018: Heart Failure Clinics
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