Giuseppe Limongelli, Daniele Masarone, Valeria Maddaloni, Marta Rubino, Fiorella Fratta, Annapaola Cirillo, Spinelli Barrile Ludovica, Roberta Pacileo, Adelaide Fusco, Guido Ronald Coppola, Francesca Pisacane, Eduardo Bossone, Paolo Calabrò, Raffaele Calabrò, Maria Giovanna Russo, Giuseppe Pacileo
Takotsubo syndrome (TTS) is an enigmatic disease with a multifactorial and still unresolved pathogenesis. A genetic predisposition has been suggested based on the few familial TTS cases. Conflicting results have been published regarding the role of functional polymorphisms in relevant candidate genes, such as α1-, β1-, and β2-adrenergic receptors; G protein-coupled receptor kinase 5; and estrogen receptors. Further research is required to help clarify the role of genetic susceptibility in TTS.
October 2016: Heart Failure Clinics