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Molecular Nutrition & Food Research

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https://www.readbyqxmd.com/read/27883285/time-and-strain-specific-downregulation-of-intestinal-epas1-via-mir-148a-by-bifidobacterium-bifidum
#1
Amel Taibi, Natasha Singh, Jianmin Chen, Stefania Arioli, Simone Guglielmetti, Elena M Comelli
SCOPE: Bifidobacteria play a role in intestinal homeostasis but molecular mechanisms remain under-investigated. The aim of this study was to assess if probiotic Bifidobacterium strains alter expression of intestinal microRNA and downstream target gene response. METHODS AND RESULTS: The expression of miR-148a and its validated target EPAS1 (endothelial PAS domain protein 1) was analyzed in Caco-2 cells and mice cecum in response to Bifidobacterium bifidum MIMBb75, B...
November 24, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27883262/phytochemicals-enhance-antioxidant-enzyme-expression-to-protect-against-nsaid-induced-oxidative-damage-of-the-gastrointestinal-mucosa
#2
REVIEW
Yu-Ting Cheng, Chi-Cheng Lu, Gow-Chin Yen
The gastrointestinal mucosa provides the first protective barrier for digested food and xenobiotics, which are easily attacked by toxic substances. Non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, diclofenac, indomethacin, and ketoprofen, are widely used in clinical medicine, but these drugs may cause oxidative stress, leading to gastrointestinal damage, such as ulcers. Lansoprazol, omeprazole, and other clinical drugs are widely used to treat duodenal and gastric ulcers and haven been shown to have multiple biological functions, such as antioxidant activity and the ability to upregulate antioxidant enzymes in vivo...
November 24, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27879044/clustering-according-to-urolithin-metabotype-explains-the-interindividual-variability-in-the-improvement-of-cardiovascular-risk-biomarkers-in-overweight-obese-individuals-consuming-pomegranate-a-randomised-clinical-trial
#3
Antonio González-Sarrías, Rocío García-Villalba, María Romo-Vaquero, Cesarettin Alasalvar, Asim Örem, Pilar Zafrilla, Francisco A Tomás-Barberán, María V Selma, Juan Carlos Espín
SCOPE: The pomegranate lipid-lowering properties remain controversial, probably due to the interindividual variability in polyphenol (ellagitannins) metabolism. OBJECTIVE: We aimed at investigating whether the microbial-derived ellagitannin-metabolizing phenotypes, i.e. urolithin metabotypes A, (UM-A), B (UM-B) and 0 (UM-0), influence the effects of pomegranate extract (PE) consumption on eighteen cardiovascular risk biomarkers in healthy overweight-obese individuals...
November 23, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27878970/association-between-the-dietary-inflammatory-index-dii-and-telomere-length-and-c-reactive-protein-from-the-national-health-and-nutrition-examination-survey-1999-2002
#4
Nitin Shivappa, Michael D Wirth, Thomas G Hurley, James R Hébert
BACKGROUND: Leukocyte telomere length (LTL) is an important biomarker of aging. This study examined whether inflammatory potential of diet, as measured by the Dietary Inflammatory Index(TM) (DII) has an impact on telomere shortening in the National Health and Nutrition Examination Survey (NHANES). We also carried out validation of the DII with C-reactive protein (CRP). METHODS: Data came from NHANES 1999-2002. LTL and CRP were assayed from leukocyte DNA and serum specimens, respectively...
November 22, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27873461/human-peripheral-blood-mononuclear-cell-in-vitro-system-to-test-the-efficacy-of-food-bioactive-compounds-effects-of-polyunsaturated-fatty-acids-and-their-relation-with-bmi
#5
Margalida Cifre, Rubén Díaz-Rúa, Rubén Varela-Calviño, Bàrbara Reynés, Jordi Pericás-Beltrán, Andreu Palou, Paula Oliver
SCOPE: To analyse usefulness of isolated human peripheral blood mononuclear cells (PBMC) to rapidly/easily reflect n-3 long-chain polyunsaturated fatty acid (LCPUFA) effects on lipid metabolism/inflammation gene profile, and evaluate if these effects are BMI-dependent. METHODS AND RESULTS: PBMC from normoweight (NW) and overweight/obese (OW/OB) subjects were incubated with physiological doses of docosahexaenoic (DHA), eicosapentaenoic acid (EPA), or their combination...
November 22, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27873458/resveratrol-enhances-brown-adipocyte-formation-and-function-by-activating-amp-activated-protein-kinase-ampk-%C3%AE-1-in-mice-fed-high-fat-diet
#6
Songbo Wang, Xingwei Liang, Qiyuan Yang, Xing Fu, Meijun Zhu, B D Rodgers, Qingyan Jiang, Michael V Dodson, Min Du
SCOPE: Enhancing the formation and function of brown adipose tissue (BAT) increases thermogenesis and hence reduces obesity. Thus, we investigate the effects of resveratrol (Resv) on brown adipocyte formation and function in mouse interscapular BAT (iBAT). METHODS AND RESULTS: CD1 mice and stromal vascular cells (SVCs) isolated from iBAT were treated with Resv. Expression of brown adipogenic and thermogenic markers, and involvement of AMP-activated protein kinase (AMPK)α1 were assessed...
November 22, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27860235/a-functional-pseudogene-nmral2p-is-regulated-by-nrf2-and-serves-as-a-co-activator-of-nqo1-in-sulforaphane-treated-colon-cancer-cells
#7
Gavin S Johnson, Jia Li, Laura M Beaver, W Mohaiza Dashwood, Deqiang Sun, Praveen Rajendran, David E Williams, Emily Ho, Roderick H Dashwood
SCOPE: The anticancer agent sulforaphane (SFN) acts via multiple mechanisms to modulate gene expression, including the induction of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-dependent signaling and the inhibition of histone deacetylase activity. Transcriptomics studies were performed in SFN-treated human colon cancer cells and in non-transformed colonic epithelial cells in order to pursue new mechanistic leads. METHODS AND RESULTS: RNA-sequencing corroborated the expected changes in cancer-related pathways after SFN treatment...
November 18, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27860207/mediterranean-diet-gene-interactions-a-targeted-metabolomics-study-in-greek-cypriot-women
#8
Maria G Kakkoura, Kleitos Sokratous, Christiana A Demetriou, Maria A Loizidou, Giorgos Loucaides, Eleni Kakouri, Andreas Hadjisavvas, Kyriacos Kyriacou
SCOPE: A high adherence to the Mediterranean diet (MD) was previously associated with a decreased risk of breast cancer (BC) among Greek-Cypriot women. Additionally, particular polymorphisms were shown to modulate this MD-BC association. Herein, we aimed to investigate the effect of polymorphisms-MD interactions on the levels of specific metabolites that could be related to dietary adherence or enzymatic activity, which is itself modulated by polymorphisms. METHODS AND RESULTS: Greek-Cypriot women who were BC controls and had the lowest or the highest MD adherence (vegetables, fruit, legumes, fish) as assessed by principal component analysis (n = 564) were included...
November 18, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27860374/chemoprevention-of-obesity-by-dietary-natural-compounds-targeting-mitochondrial-regulation
#9
REVIEW
Ching-Shu Lai, Jia-Ching Wu, Chi-Tang Ho, Min-Hsiung Pan
Mitochondria are center stage in the control of energy homeostasis in many organs and tissue including adipose tissue. Recently, abundant evidences from experimental studies have clearly supported the strong correlation between mitochondrial dysfunction in adipocytes and obesity. Various physiological conditions, such as excessive nutrition, genetic factors, hypoxia and toxins disrupt mitochondrial function by impairing mitochondrial biogenesis, dynamics and oxidative capacity. Mitochondrial dysfunction in adipocytes could have impact on differentiation, adipogenesis, insulin sensitivity and with the significant alteration in their metabolic function, which ultimately results in obesity and type 2 diabetes...
November 16, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27862930/piperine-inhibits-abca1-degradation-and-promotes-cholesterol-efflux-from-thp-1-derived-macrophages
#10
Limei Wang, Veronika Palme, Susanne Rotter, Nicole Schilcher, Malsor Cukaj, Dongdong Wang, Angela Ladurner, Elke H Heiss, Herbert Stangl, Verena M Dirsch, Atanas G Atanasov
SCOPE: Increased macrophage cholesterol efflux is considered to have anti-atherosclerotic effect counteracting cardiovascular disease. The principle pungent ingredient of the fruits of Piper nigrum, piperine, is identified in this study as a cholesterol efflux (ChE) inducer in THP-1-derived macrophages, and mechanisms underlying this effect are explored. METHODS AND RESULTS: Without affecting cell viability, piperine concentration-dependently enhances ChE in THP-1-derived macrophages from 25 to 100 μM...
November 15, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27860258/sesamol-supplementation-prevents-systemic-inflammation-induced-memory-impairment-amyloidogenesis-via-inhibition-of-nuclear-factor-kappab
#11
Zhigang Liu, Yuwei Chen, Qinglian Qiao, Yali Sun, Qian Liu, Bo Ren, Xuebo Liu
SCOPE: The aim of the present study was to investigate the inhibitory effects of sesamol, a phenolic lignan from sesame, on the systemic inflammation-induced neuroinflammation and amyloidogenesis as well as memory impairment. METHODS AND RESULTS: C57BL/6J mice were treated with 0.05% sesamol (w/v) in the drinking water for 7 weeks, and then the mice were treated by intraperitoneal injection of LPS (0.25 mg/kg) for 9 days. Sesamol supplementation significantly improved (by 36...
November 15, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27862990/effects-of-ferric-citrate-supplementation-on-advanced-glycation-end-products-in-a-rat-model-of-streptozotocin-nicotinamide-induced-diabetes
#12
Kuo-Ching Chao, Seu-Hwa Chen, Chun-Chao Chang, Yu-Chieh Lee, Chi-Mei Wang, Jung-Su Chang
SCOPE: Diabetes is associated with increased risks of anemia and activation of advanced glycation end products (AGEs) and the receptor for AGEs (RAGE). However, the effects of pharmacological doses of iron supplementation on AGE metabolism are less clear. The aim was to investigate the effect of ferric citrate supplementation on AGE metabolism. METHODS AND RESULTS: Diabetes was induced in overnight starved rats by intraperitoneal injections of 40 mg/kg streptozotocin and 120 mg/kg nicotinamide...
November 10, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27860246/prospective-study-of-the-dietary-inflammatory-index-and-risk-of-breast-cancer-in-postmenopausal-women
#13
Nitin Shivappa, Cindy K Blair, Anna E Prizment, David R Jacobs, James R Hébert
SCOPE: Diet in relation to breast cancer etiology has been studied widely, but results have remained inconsistent. Various dietary components including fruits, vegetables, and meat have been implicated through their effects on inflammation. Using data from the Iowa Women's Health Study we examine prospectively the association between the dietary inflammatory index (DII) and breast cancer incidence. METHODS AND RESULTS: DII scores were computed based on baseline dietary intake assessed by a validated 121-item food frequency questionnaire in a cohort of 34,700 women, aged 55-69 years at recruitment in 1986 and followed for incident breast cancer...
November 10, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27813270/endoplasmic-reticulum-stress-contributes-to-ferritin-molecules-mediated-macrophage-migration-via-p-selectin-glycoprotein-ligand-1
#14
Chi-Mei Wang, Yue-Hwa Chen, Yu-Chieh Lee, Jung-Su Chang
SCOPE: Obesity is associated with elevated serum ferritin and increased macrophage activation and infiltration; however, the causal mechanisms underlying this relationship remain undefined. METHODS AND RESULTS: Serum ferritin and soluble P-selectin glycoprotein ligand (sPSGL)-1 level were higher in obese adolescents and patients with moderate nonalcoholic fatty liver disease (NAFLD) compared with controls (all p < 0.05). Multivariate linear regression revealed that serum ferritin was independently associated with sPSGL-1 (B = 0...
November 4, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27813269/dietary-fibers-and-associated-phytochemicals-in-cereals
#15
REVIEW
Knud Erik Bach Knudsen, Natalja P Nørskov, Anne Katrine Bolvig, Mette Skou Hedemann, Helle Nygaard Laerke
Epidemiological studies have linked whole-grain (WG) cereal consumption to a reduced risk of developing several chronic diseases - coronary heart disease, arteriosclerosis, type-2 diabetes and some form of cancers. The underlying physiological mechanisms behind the protective effects of WG are unclear, but can most likely be assigned to a concerted action of dietary fiber (DF) and a wide variety of phytochemicals. Physiologically, it is important that soluble non-starch polysaccharides contribute to higher viscosity in the small intestine as this may influence rate and extent of digestion and absorption...
November 4, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27813248/application-of-a-low-polyphenol-or-low-ellagitannin-dietary-intervention-and-its-impact-on-ellagitannin-metabolism-in-men
#16
Kristen M Roberts, Elizabeth M Grainger, Jennifer M Thomas-Ahner, Alice Hinton, Junnan Gu, Ken Riedl, Yael Vodovotz, Ronney Abaza, Steven J Schwartz, Steven K Clinton
SCOPE: Plant polyphenols are widespread in the American diet, yet estimated intake is uncertain. We examine the application of the Polyphenol Explorer® (PED) to quantify polyphenol and ellagitannin (ET) intake of men with prostate cancer and tested the implementation of diets restricted in polyphenols or ETs. METHODS AND RESULTS: Twenty-four men enrolled in a 4-week trial were randomized to usual, low-polyphenol or low-ET diet. Estimated polyphenol and ET intakes were calculated from 3-day diet records utilizing the PED...
November 4, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27805317/fruit-and-vegetables-consumption-is-directly-associated-to-survival-after-prostate-cancer
#17
Martina Taborelli, Jerry Polesel, Maria Parpinel, Carmen Stocco, Silvia Birri, Diego Serraino, Antonella Zucchetto
SCOPE: Since the evidence on the role of diet on prostate cancer (PCa) prognosis is still controversial, we evaluated the long-term effects of fruit and vegetables consumption on survival after PCa. METHODS AND RESULTS: A retrospective cohort study included 777 men with PCa diagnosed between 1995 and 2002 in north-eastern Italy and followed-up to 2013. A validated food-frequency questionnaire assessed the usual diet in the two years before PCa diagnosis, including detailed fruit and vegetables consumption...
November 2, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27804206/pomegranate-extract-prevents-skeletal-muscle-of-mice-against-wasting-induced-by-acute-tnf-%C3%AE-injection
#18
Julie Rodriguez, Olivier Caille, Daneel Ferreira, Marc Francaux
SCOPE: We investigated whether punicalagin-rich pomegranate extract (PE) protects skeletal muscle of mice against inflammation induced by an acute injection of TNF-α. RESULTS: Mice fed with PE or standard chow during 6 wk were injected with TNF-α (100 ng/g) or vehicle and sacrificed 6 h later. Prior supplementation with PE prevented the loss of tibialis anterior mass induced by TNF-α. In skeletal muscle, the activation of the NF-κB signaling and the induction of cytokines mRNA were reduced in mice having received PE...
November 2, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27801550/herring-and-chicken-pork-meals-lead-to-differences-in-plasma-levels-of-tca-intermediates-and-arginine-metabolites-in-overweight-and-obese-men-and-women
#19
Andrew Vincent, Otto I Savolainen, Partho Sen, Nils-Gunnar Carlsson, Annette Almgren, Helen Lindqvist, Mads Vendelbo Lind, Ingrid Undeland, Ann-Sofie Sandberg, Alastair B Ross
SCOPE: What effect does replacing chicken or pork with herring as the main dietary source of protein have on the human plasma metabolome. METHOD AND RESULTS: A randomized crossover trial with fifteen healthy obese men and women (age 24-70 years). Subjects were randomly assigned to four weeks of herring diet or a reference diet of chicken and lean pork, five meals per week, followed by a washout and the other intervention arm. Fasting blood serum metabolites were analysed at 0, 2 and 4 weeks for eleven subjects with available samples, using GC-MS based metabolomics...
November 1, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27800655/relationship-between-hmf-intake-and-smf-formation-in-vivo-an-animal-and-human-study
#20
Silvia Pastoriza de la Cueva, Juana Álvarez, Ákos Végvári, Javier Montilla-Gómez, Olga Cruz-López, Cristina Delgado-Andrade, José A Rufián-Henares
SCOPE: 5-Hydroxymethylfurfural (HMF) is a furanic compound produced in heat-processed foods by non-enzymatic browning reactions. HMF has been demonstrated to be hepato- and nephrotoxic in animals with a link to its metabolite 5-sulfooxymethylfurfural (SMF). To date little is known about either the formation of SMF from ingested HMF, or the formation of DNA adducts in animals or human beings. METHODS AND RESULTS: To assess SMF in vivo formation, we first performed a study in mice treated with high/low doses of oral HMF...
November 1, 2016: Molecular Nutrition & Food Research
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