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Molecular Nutrition & Food Research

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https://www.readbyqxmd.com/read/28523759/role-of-sulfotransferases-in-resveratrol-metabolism-in-human-adipocytes
#1
Nele Gheldof, Sofia Moco, Christian Chabert, Tony Teav, Denis Barron, Jorg Hager
SCOPE: Polyphenols such as resveratrol received interest for their wide-ranging biological benefits, including anti-obesity potential, mimicking effects of caloric restriction with reduced body fat and increased energy expenditure. However, resveratrol is rapidly metabolized, and it is not completely understood which form of resveratrol is responsible for the effects observed within target cells such as adipocytes. Also the role of metabolizing enzymes has not been investigated before...
May 18, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28512779/structure-of-protein-emulsion-in-food-impacts-intestinal-microbiota-caecal-luminal-content-composition-and-distal-intestine-characteristics-in-rats
#2
Martin Beaumont, Daphné Jaoui, Véronique Douard, Damien Mat, Fanny Koeth, Bénédicte Goustard, Camille Mayeur, Stanislas Mondot, Anais Hovaghimian, Steven Le Feunteun, Catherine Chaumontet, Anne-Marie Davila, Daniel Tomé, Isabelle Souchon, Camille Michon, Gilles Fromentin, François Blachier, Marion Leclerc
SCOPE: Few studies have evaluated in vivo the impact of food structure on digestion, absorption of nutrients and on microbiota composition and metabolism. In this study we evaluated in rat the impact of two structures of protein emulsion in food on gut microbiota, luminal content composition, and intestinal characteristics. METHODS AND RESULTS: Rats received for 3 weeks two diets of identical composition but based on lipid-protein matrices of liquid fine (LFE) or gelled coarse (GCE) emulsion...
May 17, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28503853/glucuronidation-and-its-impact-on-the-bioactivity-of-6-shogaol
#3
Pei Wang, Yantao Zhao, Yingdong Zhu, Shengmin Sang
SCOPE: 6-shogaol (6S) from ginger has been reported to have diverse bioactivities and can be widely metabolized in animals and humans; however, the impact of glucuronidation on its bioactivity is still largely unknown. This study investigates the glucuronidation of 6S and its effect on cell cytotoxicity and Nrf2-inducing activities of 6S. METHODS AND RESULTS: The glucuronidated metabolite of 6S, 4-O-monoglucuronide 6S (6S-G), was synthesized and characterized for the first time...
May 14, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28500724/grape-seed-proanthocyanidin-extract-ameliorates-inflammation-and-adiposity-by-modulating-gut-microbiota-in-high-fat-diet-mice
#4
Wen Liu, Shaoqian Zhao, Jiqiu Wang, Juan Shi, Yingkai Sun, Weiqing Wang, Guang Ning, Jie Hong, Ruixin Liu
SCOPE: Obesity and associated metabolic complications is a worldwide public health issue. Gut microbiota has been recently linked to obesity and its related inflammation. In this study, we have explored the anti-inflammatory effect of grape seed proanthocyanindin extract (GSPE) in the high-fat diet (HFD)-induced obesity and identified the contribution of the gut microbiota to GSPE effects on metabolism. METHODS AND RESULTS: Mice were fed a normal diet and a high-fat diet with or without GSPE (300mg/kg body weight/day) by oral gavage for 7 weeks...
May 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28500661/is-mealworm-or-shrimp-allergy-indicative-for-food-allergy-to-insects
#5
Henrike Chp Broekman, André C Knulst, Govardus de Jong, Marco Gaspari, Constance F den Hartog Jager, Geert F Houben, Kitty Cm Verhoeckx
SCOPE: The growing world population is a key driver for the exploration of sustainable protein sources to ensure food security. Mealworm and other insects are promising candidates. Previously we found that shrimp allergic patients are at risk for mealworm allergy, and that mealworm can induce a primary allergy 3.This study set out to investigate the allergenic potential of edible insects, suggested for human consumption by agencies such as WHO/FAO, in both the shrimp (potentially cross-reactive) and primary mealworm allergic population...
May 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28499082/exacerbation-of-liver-steatosis-following-exposure-to-famine-and-overnutrition
#6
Zhiyuan Ning, Kun Zhang, Li Zhao, You Lu, Honglin Sun, Chi Chen, Xiaomin Nie, Meng Lu, Ningjian Wang, Yingli Lu
SCOPE: People suffering from famine in early life and overnutrition in adulthood may have an increased risk for liver steatosis. We aimed to investigate the effects and mechanisms of early nutrition restriction and overnutrition on de novo lipogenesis in the liver. METHODS AND RESULTS: Three-week-old male rats were food restricted for 4 weeks and refed a high-fat or normal-fat diet individually in metabolic cages for 9 weeks. Weight-matched groups were also set up...
May 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28499081/negative-correlation-between-serum-uric-acid-and-kidney-urat1-mrna-expression-caused-by-resveratrol-in-rats
#7
Cheng-Tse Lee, Li-Ching Chang, Ching-Wen Liu, Pei-Fung Wu
SCOPE: This study established a hyperuricemic rat model to elucidate the effect of resveratrol on the transport of UA in the kidney. METHODS AND RESULTS: Hyperuricemia was induced in rats through daily oral gavage of a potassium oxonate and UA mixture over 3 weeks. Our results revealed that resveratrol significantly reduced the serum UA levels but not creatinine, c-creative protein, alanine aminotransferase, or aspartate aminotransferase levels in these rats. Furthermore, renal URAT1 and OAT1 mRNA expression were significantly higher in the rats treated with allopurinol than in those with no treatment...
May 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28497652/an-isoflavone-enriched-diet-increases-skeletal-muscle-adaptation-in-response-to-physical-activity-in-ovariectomized-rats
#8
Wenya Zheng, Jonas Hengevoß, Sebastian T Soukup, Sabine E Kulling, Mingyong Xie, Patrick Diel
SCOPE: This study was to investigate anabolic adaptation of skeletal muscle in response to an isoflavone (ISO) enriched diet, training and their combinations in ovariectomized (OVX) rats. METHODS AND RESULTS: Female Wistar rats were sedentary, performed treadmill uphill running, received ISOs, or a combination of ISOs and running after ovariectomy. Body weight was increased by OVX. Both ISO and training treatment antagonized this increase. The weights of soleus and gastrocnemius muscles were increased only when training and ISOs were combined...
May 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28497612/accurate-assessment-of-alpha-gal-syndrome-using-cetuximab-and-bovine-thyroglobulin-specific-ige
#9
Da Woon Sim, Jong Sun Lee, Kyung Hee Park, Kyoung Yong Jeong, Young-Min Ye, Jae-Hyun Lee, Jung-Won Park
SCOPE: IgE against galactose-α-1,3-galactose (α-Gal) cause alpha-gal syndrome. Bovine thyroglobulin (BTG) and cetuximab share this epitope. We aimed to determine the utility of specific IgE (sIgE) against cetuximab as compared to BTG for diagnosing alpha-gal syndrome. METHODS AND RESULTS: Twelve patients with alpha-gal syndrome, 11 patients with immediate beef or pork allergy, 18 asymptomatic individuals with meat sensitivity, and 10 non-atopic subjects were enrolled...
May 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28497545/milk-protein-synthesis-is-regulated-by-t1r1-t1r3-a-g-protein-coupled-taste-receptor-through-the-mtor-pathway-in-the-mouse-mammary-gland
#10
Junqiang Liu, Yanhong Wang, Dewei Li, Yanhuan Wang, Menglu Li, Caifa Chen, Xingtang Fang, Hong Chen, Chunlei Zhang
SCOPE: Understanding the regulatory mechanism of milk protein synthesis is important to develop strategies to improve milk protein and enhance lactation performance. mTOR pathway is a crucial modulator of protein synthesis. In this study, we want to investigate if T1R1/T1R3 can regulate milk protein synthesis and mediate the mTOR pathway in the mice mammary gland in vivo. METHODS AND RESULTS: T1R1 knockout mice, WT mice, and mammary explants were used. The weigh-suckle-weigh method was used to quantify the milk yield...
May 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28493611/fucoidan-ameliorates-pancreatic-%C3%AE-cell-death-and-impaired-insulin-synthesis-in-streptozotocin-treated-%C3%AE-cells-and-mice-via-a-sirt-1-dependent-manner
#11
Wen-Chun Yu, Yen-Lin Chen, Pai-An Hwang, Tso-Hsiao Chen, Tz-Chong Chou
SCOPE: Several beneficial biological functions of fucoidan (FO) isolated from brown algae have been demonstrated. The purpose of this study was to investigate whether FO derived from Sargassum hemiphyllum ameliorates pancreatic β-cell damage and impaired insulin synthesis under diabetic condition. METHODS AND RESULTS: The effects of FO were studied in streptozotocin (STZ)-treated pancreatic β-cell line, NIT-1cells, and mice. The cell apoptosis, protein analyses, histological examination, and pancreatic function assays were performed...
May 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28493602/avenacosides-metabolism-and-potential-use-as-exposure-biomarkers-of-oat-intake
#12
Pei Wang, Junli Yang, Aaron Yerke, Shengmin Sang
SCOPE: Exposure biomarkers used for objective estimation of whole-grain (WG) intake are essential for epidemiologic studies of WG consumption, however, up to now, no exposure biomarkers were developed for WG oat intake. This study investigates the potential of oat unique components, Avenacoside-B (AVE-B) and -A (AVE-A), as exposure biomarkers of oat intake. METHODS AND RESULTS: An in vivo study performed in mice and an in vitro batch fecalfermentation study were used to investigate the potential metabolic routes of AVE-B and -A...
May 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28464483/occurrence-of-antibiotic-resistance-genes-in-the-faecal-dna-of-healthy-omnivores-ovo-lacto-vegetarians-and-vegans
#13
Vesna Milanović, Andrea Osimani, Lucia Aquilanti, Stefano Tavoletti, Cristiana Garofalo, Serena Polverigiani, Alice Litta-Mulondo, Luca Cocolin, Ilario Ferrocino, Raffaella Di Cagno, Silvia Turroni, Camilla Lazzi, Nicoletta Pellegrini, Francesca Clementi
SCOPE: The effects of long-term omnivore, ovo-lacto vegetarian and vegan diets on the occurrence of 12 antibiotic resistance (AR) genes in the human gut was studied. METHODS AND RESULTS: The faeces of 144 healthy volunteers recruited from Turin, Bari, Bologna and Parma were screened for the occurrence of genes conferring resistance to tetracyclines, macrolide-lincosamide-streptogramin B, vancomycin and β-lactams. Overall, erm(B), tet(W) and tet(M) were detected at the highest frequency...
May 2, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28464422/recombinant-ostreolysin-induces-brown-fat-like-phenotype-in-hib-1b-cells
#14
Tom Oren, Lili Nimri, Einav Yehuda-Shnaidman, Katy Staikin, Yitzhak Hadar, Assaf Friedler, Hadar Amartely, Michal Slutzki, Antonella Di Pizio, Masha Y Niv, Irena Peri, Lutz Graeve, Betty Schwartz
SCOPE: Brown adipose tissue (BAT) is the main regulator of thermogenesis by increasing energy expenditure through the uncoupling of oxidative metabolism from ATP synthesis. There is a growing body of evidence for BAT being the key responsible organ in combating obesity and its related disorders. Herein we propose the fungal protein ostreolysin (Oly), which has been previously shown to bind to cholesterol-enriched raft-like membrane domains (lipid rafts) of mammalian cells, as a suitable candidate for interaction with brown preadipocytes...
May 2, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28463404/a-synbiotic-composed-of-lactobacillus-fermentum-cect5716-and-fos-prevents-the-development-of-fatty-acid-liver-and-glycemic-alterations-in-rats-fed-a-high-fructose-diet-associated-with-changes-in-the-microbiota
#15
Belén Rivero-Gutiérrez, Reyes Gámez-Belmonte, María Dolores Suárez, José Luis Lavín, Ana María Aransay, Mónica Olivares, Olga Martínez-Augustin, Fermín Sánchez de Medina, Antonio Zarzuelo
We investigated the effect of a high fructose diet (HFD) on Sprague Dawley rats and the impact of a synbiotic composed of Lactobacillus fermentum CECT5716 and fructooligosaccharides. Feeding the HFD for 5 weeks resulted in liver steatosis and insulin resistance but not obesity. These changes were associated with increased production of short-chain fatty acids and increased Bacteroidetes in feces, with an augmented Bacteroidetes/Firmicutes ratio, among other changes in the microbiota. In addition, barrier function was weakened, with increased LPS plasma levels...
May 2, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28457022/quercetin-protects-against-atherosclerosis-by-inhibiting-dendritic-cell-activation
#16
Weiqun Lin, Wenting Wang, Dongliang Wang, Wenhua Ling
SCOPE: Quercetin is a typical flavonol with atheroprotective effects, but the effect of quercetin on dendritic cell (DC) maturation in relation to atherosclerosis has not yet been clearly defined. Thus, we investigated whether quercetin can inhibit DC maturation and evaluated its potential value in atherosclerosis progression in ApoE(-/-) mice. METHODS AND RESULTS: Quercetin consumption inhibited DC activation, inflammatory response and suppressed the progression of atherosclerosis in ApoE(-/-) mice...
April 29, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28457017/signatures-of-anthocyanin-metabolites-identified-in-humans-inhibit-biomarkers-of-vascular-inflammation-in-human-endothelial-cells
#17
Emily F Warner, Michael J Smith, Qingzhi Zhang, K Saki Raheem, David O'Hagan, Maria A O'Connell, Colin D Kay
SCOPE: The physiological relevance of contemporary cell culture studies is often perplexing, given the use of unmetabolized phytochemicals at supraphysiological concentrations. We investigated the activity of physiologically relevant anthocyanin metabolite signatures, derived from a previous pharmacokinetics study of 500 mg (13) C5 -cyanidin-3-glucoside in 8 healthy participants, on soluble vascular adhesion molecule-1 (VCAM-1) and interleukin-6 (IL-6) in human endothelial cells. METHODS AND RESULTS: Signatures of peak metabolites (previously identified at 1, 6 and 24 h post-bolus) were reproduced using pure standards and effects were investigated across concentrations ten-fold lower and higher than observed mean (<5 μM) serum levels...
April 29, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28444960/in-vivo-absorption-and-metabolism-of-leptosperin-and-methyl-syringate-abundantly-present-in-manuka-honey
#18
Akari Ishisaka, Shinichi Ikushiro, Mie Takeuchi, Yukako Araki, Maki Juri, Yui Yoshiki, Yoshichika Kawai, Toshio Niwa, Noritoshi Kitamoto, Toshiyuki Sakaki, Hirohito Ishikawa, Yoji Kato
SCOPE: Manuka honey, which shows strong non-peroxide-dependent antibacterial activity, contains unique components, such as methyl syringate 4-O-β-D-gentiobioside (leptosperin) and its aglycone, methyl syringate (MSYR). To determine the potential for biological activity evoked by the ingestion of leptosperin and MSYR, we investigated the absorption and metabolism of these components in manuka honey. METHODS AND RESULTS: The incubation of MSYR with liver microsomes or S9 fractions in vitro resulted in the formation of MSYR-glucuronide (MSYR-GA), MSYR-sulfate (MSYR-S), and syringic acid as metabolites...
April 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28444884/novel-urinary-alkylresorcinol-metabolites-as-biomarkers-of-whole-grain-intake-in-free-living-swedish-adults
#19
Roksana Wierzbicka, Galia Zamaratskaia, Afaf Kamal-Eldin, Rikard Landberg
SCOPE: Most studies on the role of whole grain for health rely on self-reported intake data, which are prone to measurement errors. There is a need for dietary biomarkers that can provide an objective measure of intake. Alkylresorcinols (AR) and their main metabolites 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-propanoic acid (DHPPA) have been proposed as biomarkers for whole grain (WG) wheat and rye intake. METHODS AND RESULTS: The medium-term reproducibility and relative validity of four putative urinary AR metabolites (3,5-dihydroxycinnamic acid (DHCA), 5-(3,5-dihydroxyphenyl) pentanoic acid (DHPPTA), 2-(3,5-dihydroxybenzamido)acetic acid (DHBA-glycine) and 3,5-dihydroxycinnamic acid amide (DHCA-amide)) as biomarkers for WG intake were investigated...
April 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28440064/synthetic-and-analytical-strategies-for-the-quantification-of-phenyl-%C3%AE-valerolactone-conjugated-metabolites-in-human-urine
#20
Nicoletta Brindani, Pedro Mena, Luca Calani, Iris Benzie, Siu-Wai Choi, Furio Brighenti, Franca Zanardi, Claudio Curti, Daniele Del Rio
SCOPE: The contribution of the gut microbiota to the metabolism of catechins and proanthocyanidins remains unclear. Phenyl-γ-valerolactones have been identified as the most representative metabolites of these dietary flavan-3-ols, but their accurate quantification has posed problems because of a lack of appropriate bioanalytical standards. This work aimed at synthesizing a novel set of sulphate- and glucuronide-conjugated phenyl-γ-valerolactones and at developing an analytical platform using UHPLC-ESI-MS/MS for their quantification in urine...
April 25, 2017: Molecular Nutrition & Food Research
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