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Molecular Nutrition & Food Research

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https://www.readbyqxmd.com/read/28333398/dietary-cholesterol-interacts-with-srebf1-to-modulate-obesity-in-chinese-children
#1
Shixiu Zhang, Xinying Lin, Henry Lynn, Guifa Xu, Jun Li, Changfeng Zhao, Mingmei Li
SCOPE: Sterol Regulatory Element Binding Protein 1 Gene (SREBF1) is an important candidate gene for obesity that could be affected by cholesterol. Different SREBF1 gene variants may have distinct responses to cholesterol, leading to different risks for obesity and obesity-related metabolic traits. Thus, we performed a gene-by-diet correlation analysis to test whether SREBF1 gene variation modulate the relationship between cholesterol and obesity. METHODS AND RESULTS: A total of 642 school-aged children in Jinan, China, were selected by stratified cluster nested sampling...
March 23, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28324642/cinnamon-reduces-inflammatory-response-in-intestinal-fibroblasts-in-vitro-and-in-colitis-in-vivo-leading-to-decreased-fibrosis
#2
Yvonne Hagenlocher, Sabrina Satzinger, Mehtap Civelek, Katharina Feilhauer, Jörg Köninger, Stephan C Bischoff, Axel Lorentz
Intestinal fibrosis, a complication of inflammatory bowel disease, is currently being addressed by surgery alone, with no adequate alternative therapy available for patients. We propose that anti-inflammatory plant substances like cinnamon extract (CE) or its main compound cinnamaldeyde (CA) could aid in therapy. We recently found CE reducing inflammation in murine colitis. Here, we analysed effects of CE on fibrosis in IL-10(-/-) colitis METHODS AND RESULTS: IL-10(-/-) and wild type (wt) mice were orally treated with/without vehicle or CE...
March 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28322000/postprandial-triglyceride-rich-lipoproteins-promote-lipid-accumulation-and-apolipoprotein-b-48-receptor-transcriptional-activity-in-human-circulating-and-murine-bone-marrow-neutrophils-in-a-fatty-acid-dependent-manner
#3
Almudena Ortega-Gómez, Lourdes M Varela, Sergio Lopez, Sergio Montserrat de la Paz, Rosario Sanchez, Francisco J G Muriana, Beatriz Bermúdez, Rocío Abia
SCOPE: Postprandial triglyceride-rich lipoproteins (TRLs) promote atherosclerosis. Recent research points the bone marrow (BM) as a primary site in atherosclerosis. We elucidated how the acute administration of MUFAs, omega-3 PUFAs and saturated fatty acids (SFAs) affects human circulating and murine BM neutrophil lipid accumulation and functionality. METHODS AND RESULTS: Postprandial hypertriglyceridemia was induced in healthy subjects and Apoe-/- mice by the acute administration of dietary fats enriched in MUFAs, PUFAs or SFAs...
March 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28319651/mediterranean-tomato-based-sofrito-protects-against-vascular-alterations-in-obese-zucker-rats-by-preserving-no-bioavailability
#4
Rosalia Rodriguez-Rodriguez, Francesc Jiménez-Altayó, Laia Alsina, Yara Onetti, Jose F de Alvarenga, Carmen Claro, Elena Ogalla, Nuria Casals, Rosa M Lamuela-Raventos
SCOPE: Sofrito, a key component of the Mediterranean diet, provides nutritional interest due to its high content in bioactive compounds from tomato and olive oil, and especially to the lipid matrix in which these compounds are found. In this study, the potential beneficial effects of dietary intake of sofrito on obesity-related vascular alterations were explored in obese Zucker rats. METHODS AND RESULTS: Obese and lean rats were fed a control diet supplemented or not with 2% (w/w) sofrito for 8 weeks...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28319645/the-atypical-genesis-and-bioavailability-of-the-plant-based-small-rna-mir2911-bulking-up-while-breaking-down
#5
Jian Yang, Natee Kongchan, Cecilia Primo Planta, Joel R Neilson, Kendal D Hirschi
SCOPE: The uptake of dietary plant small RNAs (sRNAs) in consumers remains controversial, which is mainly due to low dietary content in combination with poor fractional absorption. MIR2911, among all the plant sRNAs including microRNAs, has been shown to be one of the most robustly absorbed sRNAs. Here we analyze the unusual abundance and unique genesis of MIR2911 during vegetable processing. METHODS AND RESULTS: Using qRT-PCR, the abundance of MIR2911 increased dramatically in macerated tissues while other microRNAs degraded...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28318108/neonatal-mono-colonization-of-germ-free-mice-with-lactobacillus-casei-enhances-casein-immunogenicity-after-oral-sensitization-to-cow-s-milk
#6
Matieny Aicha Maiga, Stéphanie Morin, Hervé Bernard, Sylvie Rabot, Karine Adel -Patient, Stéphane Hazebrouck
SCOPE: Food allergy is an increasing global health problem and perinatal administration of probiotic bacteria is currently under investigation in order to prevent the development of allergic diseases. Here, we investigated the impact of neonatal mono-colonization of mice with Lactobacillus casei BL23 on an oral sensitization to cow's milk. METHODS AND RESULTS: Mono-colonized (LC) mice were obtained by inoculating L. casei to germ-free (GF) parents. Nine-week-old GF, LC and conventional (CV) mice were orally sensitized to cow's milk with cholera toxin as adjuvant...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28318092/lycopene-and-risk-of-cardiovascular-diseases-a-meta-analysis-of-observational-studies
#7
Bo Song, Kai Liu, Yuan Gao, Lu Zhao, Hui Fang, Yusheng Li, Lulu Pei, Yuming Xu
SCOPE: The aim of current meta-analysis was to investigate the relation between lycopene and risk of cardiovascular diseases (CVD). METHODS AND RESULTS: Studies concerning about the association between lycopene and risk of CVD were searched on Pubmed, Embase, and Web of Science from inception to October 2016. A total of 14 eligible studies were identified. A significantly inverse association with a pooled risk ratio (RR) of 0.83 (95% CI: 0.76-0.90) was shown between lycopene exposure and risk of CVD...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28317313/profiling-of-antioxidative-enzyme-expression-induced-by-various-food-components-using-targeted-proteome-analysis
#8
Sven Bartenbacher, Christiane Östreicher, Monika Pischetsrieder
SCOPE: A method was developed for targeted proteome analysis of the expression profile of a set of antioxidative enzymes in rat macrophages and applied to screen the antioxidative potential of several food components/foods. METHODS AND RESULTS: Expression profiles of heme oxygenase 1, peroxiredoxin 1, thioredoxin reductase 1, glutathione reductase, glutathione-S transferase P1, and superoxide dismutase 1 were analyzed by nanoLC-MS/MS in selected scheduled reaction monitoring (sSRM) mode monitoring 2-3 peptides per protein and 3 transitions per peptide...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28317281/comparison-of-dietary-polyphenols-for-protection-against-molecular-mechanisms-underlying-non-alcoholic-fatty-liver-disease-in-a-cell-model-of-steatosis
#9
Hossein Rafiei, Kosar Omidian, Brian Bandy
SCOPE: Dietary polyphenols have shown promise in protecting the liver against non-alcoholic fatty liver disease. The relative effectiveness and mechanisms of different polyphenols however is mostly unknown. METHODS AND RESULTS: In a model of steatosis using HepG2 hepatocytes, we evaluated the protective effects of different classes of polyphenols and the contributing mechanisms. Treatment of the cells with oleic acid increased ROS generation and expression of TNFα, decreased expression of UCP2 and decreased mitochondrial content and markers of biogenesis...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28296229/phytosterol-mediated-inhibition-of-intestinal-cholesterol-absorption-in-mice-is-independent-of-liver-x-receptor
#10
Lídia Cedó, David Santos, Iziar A Ludwig, Reija Silvennoinen, Annabel García-León, Leena Kaipiainen, José M Carbó, Annabel F Valledor, Helena Gylling, Maria-José Motilva, Petri T Kovanen, Miriam Lee-Rueckert, Francisco Blanco-Vaca, Joan Carles Escolà-Gil
SCOPE: Previous studies have proposed that phytosterols activate liver X receptors (LXR) in the intestine, thereby reducing intestinal cholesterol absorption and promoting fecal cholesterol excretion. METHODS AND RESULTS: In the present study, we examined the effects of dietary phytosterol supplementation on intestinal cholesterol absorption and fecal neutral sterol excretion in LXRαβ-deficient mice, and wild-type mice treated with synthetic high-affinity LXRαβ agonists...
March 15, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28296348/consumption-of-a-diet-rich-in-brassica-vegetables-is-associated-with-a-reduced-abundance-of-sulphate-reducing-bacteria-a-randomised-crossover-study
#11
Lee Kellingray, Henri S Tapp, Shikha Saha, Joanne F Doleman, Arjan Narbad, Richard F Mithen
SCOPE: We examined whether a Brassica-rich diet was associated with an increase in the relative abundance of intestinal lactobacilli and sulphate-reducing bacteria (SRB), or alteration to the composition of the gut microbiota, in healthy adults. METHODS AND RESULTS: A randomised crossover study was performed with ten healthy adults who were fed a high- and a low-Brassica diet for 2-week periods, with a 2-week washout phase separating the diets. The high-Brassica diet consisted of six 84 g portions of broccoli, six 84 g portions of cauliflower, and six 300 g portions of a broccoli and sweet potato soup...
March 10, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28276197/phenyl-%C3%AE-valerolactones-flavan-3-ol-colonic-metabolites-protect-brown-adipocytes-from-oxidative-stress-without-affecting-their-differentiation-or-function
#12
Laura Mele, Stefania Carobbio, Nicoletta Brindani, Claudio Curti, Sergio Rodriguez-Cuenca, Guillaume Bidault, Pedro Mena, Ilaria Zanotti, Michele Vacca, Antonio Vidal-Puig, Daniele Del Rio
SCOPE: Consumption of products rich in flavan-3-ols, such as tea and cocoa, has been associated with decreased obesity, partially dependent on their capacity to enhance energy expenditure. Despite these phenolics having been reported to increase the thermogenic program in brown and white adipose tissue, flavan-3-ols are vastly metabolised in vivo to phenyl-γ-valerolactones. Therefore, we hypothesize that phenyl-γ-valerolactones may directly stimulate the differentiation and the activation of brown adipocytes...
March 9, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28271601/phytochemical-compounds-in-sport-nutrition-synephrine-and-hydroxycitric-acid-hca-as-examples-for-evaluation-of-possible-health-risks
#13
REVIEW
Nadiya Bakhiya, Rainer Ziegenhagen, Karen I Hirsch-Ernst, Birgit Dusemund, Klaus Richter, Katharina Schultrich, Sophie Pevny, Bernd Schäfer, Alfonso Lampen
Numerous food supplements contain phytochemical compounds as active ingredients. Though such supplements are often perceived by consumers as being risk-free, the safety of many of them is currently uncertain. The present review provides two examples for risk assessment for phytochemical ingredients which are used in certain supplements marketed for sportspeople - synephrine (extracted from fruits of Citrus aurantium) and hydroxycitric acid (HCA, isolated from fruits of Garcinia cambogia). Animal and human studies as well as case reports provide evidence for cardiovascular effects due to ingestion of high synephrine doses, especially in combination with caffeine and physical exertion...
March 8, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28267258/normal-human-immune-cells-are-sensitive-to-telomerase-inhibition-by-brassica-derived-3-3-diindolylmethane-partly-mediated-via-er%C3%AE-%C3%AE-ap1-signalling
#14
Corinna Herz, Hoai Thi Thu Tran, Steffen Landerer, Johanna Gaus, Nina Schlotz, Lia Lehr, Wolfgang R Schäfer, Oliver Treeck, Grace Akinyi Odongo, Ivan Skatchov, Evelyn Lamy
SCOPE: Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) from Brassica plants are regarded as promising anticancer phytochemicals. The enzyme telomerase is a very attractive target for cancer therapeutics; in normal cells such as lymphocytes, it plays a decisive role for cell maintenance. The effect of I3C and DIM on telomerase in normal human immune cells (PBMC) was studied compared to leukaemia cells (HL-60). Signalling of telomerase regulation via estrogen receptor (ER) was addressed...
March 7, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28267248/lycopene-and-tomato-powder-supplementation-similarly-inhibit-high-fat-diet-induced-obesity-inflammatory-response-and-associated-metabolic-disorders
#15
Soumia Fenni, Habib Hammou, Julien Astier, Lauriane Bonnet, Esma Karkeni, Charlène Couturier, Franck Tourniaire, Jean-François Landrier
SCOPE: Several studies have linked the high intake of lycopene or tomatoes products with lower risk for metabolic diseases. The aim of the present study was to evaluate and to compare the effect of lycopene and tomato powder on obesity associated disorders. METHODS AND RESULTS: Male C57BL/J6 mice were assigned into 4 groups to receive: control diet (CD), high fat diet (HFD), high fat diet supplemented with lycopene or with tomato powder (TP) for 12 weeks. In HFD condition, lycopene and TP supplementation significantly reduced adiposity index, organ and relative organ weights, serum triglycerides, free fatty acids, 8-iso-prostaglandin GF2α and improved glucose homeostasis, but did not affect total body weight...
March 7, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28266134/a-small-plant-with-big-benefits-fenugreek-trigonella-foenum-graecum-linn-for-disease-prevention-and-health-promotion
#16
REVIEW
Kalyan C Nagulapalli Venkata, Debasis Bagchi, Anupam Bishayee
Plant-derived natural products have long-standing utility towards treating degenerative diseases. It is estimated that about two-third of world population depend on traditional medicine for primary medical needs. Fenugreek (Trigonella foenum-graecum Linn.), a short-living annual medicinal plant belonging to Fabaceae family, is used extensively in various parts of the world as herb, food, spice and traditional medicine. Fenugreek is considered as one of the oldest medicinal plants and its health-promoting effects have been cited in Ayurveda and traditional Chinese medicine...
March 7, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28245338/boswellia-serrata-resin-extract-alleviates-azoxymethane-aom-dextran-sodium-sulfate-dss-induced-colon-tumorigenesis
#17
Ya-Chun Chou, Joon Hyuk Suh, Yu Wang, Manoj Pahwa, Vladimir Badmeav, Chi-Tang Ho, Min-Hsiung Pan
SCOPE: Boswellia serrata (BS) resin is a popular dietary supplement for joint nourishment. In this study, we investigated the chemopreventive effects of dietary BS extract and its impact of gut microbiota on azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis-associated colon cancer in mice. METHODS AND RESULTS: Male ICR mice were injected with AOM and 2% DSS via drinking water. The mice were fed with 0.25% or 0.5% BS extract, and colonic tissue were collected at 15 wk...
February 28, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28239993/maternal-betaine-supplementation-in-rats-induces-intergenerational-changes-in-hepatic-igf-1-expression-and-dna-methylation
#18
Nannan Zhao, Shu Yang, Yun Hu, Haibo Dong, Ruqian Zhao
SCOPE: Betaine is widely used in animal nutrition to promote growth. Here we aimed to investigate whether maternal betaine supplementation during pregnancy can exert multigenerational effects on growth across two generations and the possible epigenetic modifications associated to such effects. METHODS AND RESULTS: In this study, 3-month-old female Sprague-Dawley rats were fed diet supplemented with 1% betaine throughout the pregnancy and lactation. Betaine-supplemented dams produced bigger litter but smaller F1 pups at birth and weaning...
February 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28239982/phytochemicals-in-quinoa-and-amaranth-grains-and-their-antioxidant-anti-inflammatory-and-potential-health-beneficial-effects-a-review
#19
Yao Tang, Rong Tsao
Quinoa (Chenopodium quinoa Willd.) and amaranth (Amaranthus cruentus L.) are pseudocereal grains rich in both macronutrients and micronutrients including vitamins and minerals. The proteins are particularly of high nutritional quality due to the outstanding balance of essential amino acids. However, recent research strongly suggests that the essential nutrients such as phytochemicals of quinoa and amaranth may also with potential health beneficial effects. This review focuses on the phytochemical composition of quinoa and amaranth seeds, the antioxidant and anti-inflammatory activities of hydrophilic (e...
February 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28233461/high-fat-diet-and-associated-changes-in-the-expression-of-micro-rnas-in-tissue-lessons-learned-from-animal-studies
#20
Robin A Wilson, William Deasy, Alan Hayes, Matthew B Cooke
Environment and genetic factors play an important role in the development of obesity, and diet is one of the main contributing factors to this disease. High fat intake is associated with body weight gain, leading to obesity and other metabolic diseases. MicroRNAs (miRNAs) are a group of small, non-coding RNAs that are important regulators of gene expression at post transcriptional level. Studies have shown that high fat intake, independent of body weight status, can significantly impact both negatively and positively the expression of miRNAs and thus the biological function of tissues such as adipose, skeletal and cardiac muscle, liver, neuronal and endothelial...
February 24, 2017: Molecular Nutrition & Food Research
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