Read by QxMD icon Read

Molecular Nutrition & Food Research

Rebekka Thøgersen, Josué L Castro-Mejía, Ulrik Kraemer Sundekilde, Lars H Hansen, Axel Kornerup Hansen, Dennis Sandris Nielsen, Hanne Christine Bertram
SCOPE: Processed meat intake is associated with a potential increased colorectal cancer (CRC) risk. In contrast, dietary fiber consumption has been found to lower CRC risk, possibly via mechanisms involving the gut microbiota (GM) and its metabolites. This study investigated the effect of inulin enrichment of a common pork sausage product on GM composition and activity in healthy rats. METHODS AND RESULTS: Thirty Sprague-Dawley rats were fed a diet based on either an inulin-enriched sausauge (n = 12), a corresponding control sausage without enrichment (n = 12) or a standard chow diet (n = 6) during a four-week intervention...
July 13, 2018: Molecular Nutrition & Food Research
Marija Perusko, Manon van Roest, Dragana Stanic-Vucinic, Peter J Simons, Raymond Pieters, Tanja Cirkovic Velickovic, Joost J Smit
SCOPE: During food processing the Maillard reaction (МR) may occur resulting in the formation of glycated proteins. Glycated proteins are of particular importance in food allergy since glycation may influence interactions with immune system. This study compared native and extensively glycated milk allergen β-lactoglobulin (BLG), in their interactions with cells crucially involved in allergy. METHODS AND RESULTS: BLG was glycated in MR and characterized. Native and glycated BLG were tested in experiments of epithelial transport, uptake and degradation by DCs, T-cell cytokine responses and basophil cell degranulation using ELISA and flow cytometry...
July 13, 2018: Molecular Nutrition & Food Research
Vivian A Paschoal, Thiago Belchior, Mariane T Amano, Marina Burgos-Silva, Albert S Peixoto, Juliana Magdalon, Thayna S Vieira, Maynara L Andrade, Mayara F Moreno, Patricia Chimin, Niels O Câmara, William T Festuccia
SCOPE: To test whether myeloid cells Tsc1 deletion and therefore constitutive activation of the nutrient sensor mTORC1 protects from high-fat diet (HFD)-induced obesity, glucose intolerance and adipose tissue inflammation. METHODS AND RESULTS: Mice with Tsc1 deletion in myeloid cells (MTsc1KO) and littermate controls (MTsc1WT) were fed with HFD for 8 weeks and evaluated for body weight, glucose homeostasis and adipose tissue inflammation. MTsc1KO mice were protected from HFD-induced obesity and glucose intolerance...
July 12, 2018: Molecular Nutrition & Food Research
Dong Yeon Kim, Min-Kyung Kang, Eun-Jung Lee, Yun-Ho Kim, Hyeongjoo Oh, Young-Hee Kang
SCOPE: The maintenance of interpodocyte slit diaphragm is critical in the sieving function of glomerular filtration barrier. Eucalyptol is a natural constituent in aromatic plants with antioxidant properties. This study investigated whether and how eucalyptol inhibited podocyte slit diaphragm malfunction in glucose-exposed podocytes and diabetic mouse kidneys. METHODS AND RESULTS: Podocytes were incubated in media containing 33 mM glucose with 1-20 μM eucalyptol...
July 10, 2018: Molecular Nutrition & Food Research
Laure Castan, Clélia Villemin, Mathilde Claude, Philippe Aubert, Tony Durand, Michel Neunlist, Chantal Brossard, Antoine Magnan, Marie Bodinier, Grégory Bouchaud
SCOPE: Food allergies result from a complex immune response involving both innate and adaptive immune cells. Major proteins of wheat flour, gliadins, appear to be important allergens, and their characteristics can influence the allergic response. Our study investigates the immune reaction when developing a food allergy to gliadins in native, deamidated or hydrolyzed forms. METHODS: We analyzed the immune response after one or two intraperitoneal sensitizations and after oral challenge with each gliadin form...
July 6, 2018: Molecular Nutrition & Food Research
Sara Ramos-Romero, Mercè Hereu, Lidia Atienza, Josefina Casas, Núria Taltavull, Marta Romeu, Susana Amézqueta, Gabriel Dasilva, Isabel Medina, Josep L Torres
SCOPE: The goals of this work were to test if d-fagomine, an iminosugar that reduces body weight gain, can delay the appearance of a fat-induced prediabetic state in a rat model and to explore possible mechanisms behind its functional action. METHODS AND RESULTS: Wistar Kyoto rats were fed a high-fat diet supplemented with d-fagomine (or not; for comparison) or a standard diet (controls) for 24 weeks. The variables measured were: fasting blood glucose and insulin levels; glucose tolerance; diacylglycerols as intracellular mediators of insulin resistance in adipose tissue, liver and muscle; inflammation markers (plasma IL-6 and leptin, and liver and adipose tissue histology markers); eicosanoids from arachidonic acid as lipid mediators of inflammation; and the populations of Bacteroidetes, Firmicutes, Enterobacteriales and Bifidobacteriales in feces...
July 6, 2018: Molecular Nutrition & Food Research
Patricia López, Mónica Sánchez, Claudia Perez-Cruz, Laura A Velázquez-Villegas, Tauqeerunnisa Syeda, Miriam Aguilar-López, Ana K Rocha-Viggiano, María Del Carmen Silva-Lucero, Ivan Torre-Villalvazo, Lilia G Noriega, Nimbe Torres, Armando R Tovar
SCOPE: The aim of this study was to assess whether the long-term addition of genistein to a high-fat diet can ameliorate the metabolic and the cognitive alterations and whether the changes can be associated with modifications to the gut microbiota. METHODS AND RESULTS: Thus, C57/BL6 mice were fed either a control (C) diet, a high-fat (HF) diet or a high-fat diet containing genistein (HFG) for 6 months. During the study, indirect calorimetry, IP glucose tolerance tests and behavioural analyses were performed...
July 6, 2018: Molecular Nutrition & Food Research
Anna Pedret, Sara Fernández-Castillejo, Rosa-Maria Valls, Úrsula Catalán, Laura Rubió, Marta Romeu, Alba Macià, Maria Carmen López de Las Hazas, Marta Farràs, Montse Giralt, Juana I Mosele, Sandra Martín-Peláez, Alan T Remaley, Maria-Isabel Covas, Montse Fitó, Maria-José Motilva, Rosa Solà
SCOPUS: The main findings of the "Virgin Olive Oil and HDL Functionality" (VOHF) study and other related studies on the effect of phenol-enriched virgin olive oil (VOO) supplementation on cardiovascular disease are integrated in the present work. METHODS AND RESULTS: VOHF assessed whether VOOs, enriched with their own phenolic compounds (FVOO) or with those from thyme (FVOOT), improve quantity and functionality of HDL. In this randomized, double-blind, crossover, and controlled trial, 33 hypercholesterolemic subjects received a control VOO (80 mg/kg), FVOO (500 mg/kg), and FVOOT (500 mg/kg;1:1) for 3 weeks...
June 29, 2018: Molecular Nutrition & Food Research
Jagdish Mahale, Rajinder Singh, Lynne M Howells, Robert G Britton, Sameena M Khan, Karen Brown
SCOPE: Curcumin, (from turmeric), has been extensively investigated for potential beneficial properties in numerous diseases. Most work has focussed on supra-dietary concentrations/doses that would necessitate curcumin supplementation. However, much evidence instigating curcumin research is underpinned by epidemiological data based on low dietary intake via turmeric consumption. METHODS AND RESULTS: Here, we describe a novel, highly sensitive liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS/MS) method for detection of curcuminoids...
June 26, 2018: Molecular Nutrition & Food Research
Anna Riedl, Nina Wawro, Christian Gieger, Christa Meisinger, Annette Peters, Michael Roden, Florian Kronenberg, Christian Herder, Wolfgang Rathmann, Henry Völzke, Martin Reincke, Wolfgang Koenig, Henri Wallaschofski, Hans Hauner, Hannelore Daniel, Jakob Linseisen
SCOPE: Metabotyping describes the grouping of metabolically similar individuals. We aimed to identify valid metabotypes in a large cohort for targeted dietary intervention, e.g. for disease prevention. METHODS AND RESULTS: We grouped 1729 adults aged 32-77 years of the German population-based KORA F4 study (2006-2008) using k-means cluster analysis based on 34 biochemical and anthropometric parameters. We identified three metabolically distinct clusters showing significantly different biochemical parameter concentrations...
June 25, 2018: Molecular Nutrition & Food Research
Chun-Feng Guo, Ya-Hong Yuan, Tian-Li Yue, Jing-Yan Li
SCOPE: Rats and hamsters are the most commonly used animal models for evaluating the hypocholesterolemic activity of potential probiotic strains, whereas little or no information has been reported on whether the animal models would affect the experimental conclusions regarding the hypocholesterolemic efficacy of the strains. METHODS AND RESULTS: Both high-cholesterol-fed rats and hamsters were intragastrically administered viable cells of bile salt hydrolase (BSH)-active Lactobacillus acidophilus K16 once daily (1 × 1010 CFU/kg body weight) for 28 d...
June 25, 2018: Molecular Nutrition & Food Research
Evangelina Capobianco, Dalmiro Gomez Ribot, Daiana Fornes, Theresa L Powell, Cecilia Levieux, Thomas Jansson, Alicia Jawerbaum
SCOPE: Offspring from rats with mild diabetes develop gestational diabetes (GDM). We tested the hypothesis that an olive oil-supplemented diet attenuates placental oxidative stress/inflammation, activation of mTOR signaling and inhibition of PPARγ and fetal overgrowth in GDM offspring from mild diabetic rats. METHODS AND RESULTS: Female offspring from rats with mild diabetes (group that developed GDM) and controls were fed with either a standard diet or a 6% olive oil-supplemented diet during pregnancy...
June 25, 2018: Molecular Nutrition & Food Research
Mamoru Kushida, Ran Okouchi, Yui Iwagaki, Masaki Asano, Ming Xuan Du, Kazushi Yamamoto, Tsuyoshi Tsuduki
SCOPE: In this study, we fed mice a soybean diet before or after fermentation to allow direct comparison of the anti-obesity effect of fermentation. METHODS: C57BL6J mice were fed high fat diets containing boiled soybeans (pre-fermentation) or Natto (post-fermentation) for four weeks. Pre-fermented cooked soybeans or Natto was added at levels of 2.5% and 5%, which are the amounts that can be ingested in a normal diet once and twice a day. In addition, mice gut microbiota from fecal samples were analyzed to explore the mechanisms of effects caused by fermentation...
June 25, 2018: Molecular Nutrition & Food Research
Tohru Hira, Shono Ogasawara, Asuka Yahagi, Minami Kamachi, Jiaxin Li, Saki Nishimura, Masayoshi Sakaino, Takatoshi Yamashita, Shigenobu Kishino, Jun Ogawa, Hiroshi Hara
SCOPE: The secretion of gut hormones, such as cholecystokinin (CCK) is stimulated by fatty acids. Although a chain length-dependent mechanism has been proposed, other structural relationships to releasing activity remain unclear. We aimed to elucidate specific structures in fatty acids that are responsible for their CCK-releasing activity, and related sensing mechanisms in enteroendocrine cells. METHODS AND RESULTS: We examined CCK secretory activities in a murine CCK-producing cell line STC-1 by exposing the cells to various modified fatty acids produced by gut lactic acid bacteria...
June 25, 2018: Molecular Nutrition & Food Research
Pan Zhuang, Qiyang Shou, Wenqiao Wang, Lilin He, Jun Wang, Jingnan Chen, Yu Zhang, Jingjing Jiao
SCOPE: To assess the associations of dietary linoleic acid (LA) and α-linolenic acid (ALA) with type 2 diabetes (T2D) risk in a population-based cohort and further explore the mechanism of action in a high-fat-diet induced obese (DIO) mouse model. METHODS AND RESULTS: The occurrence of T2D among 15,100 healthy Chinese adults from China Health and Nutrition Survey (CHNS, 1997-2011) were followed up for a median of 14 years. The relations of ALA and LA intakes with T2D risk were modified by BMI, with significant associations restricted to obese/overweight subjects...
June 23, 2018: Molecular Nutrition & Food Research
Peiyi Liu, Hongkun Lin, Yanyan Xu, Feng Zhou, Jing Wang, Jingjing Liu, Xinhong Zhu, Xiaoping Guo, Yuhan Tang, Ping Yao
SCOPE: Naturally occurring quercetin has been found to induce mitophagy and prevent non-alcoholic fatty liver disease (NAFLD). However, it still remains elusive whether frataxin upregulation by quercetin contributes to the beneficial effect through mitophagy or not. METHODS AND RESULTS: Adult male C57BL/J mice were fed a high fat diet (HFD, 60% of energy from fat) with quercetin (100 mg/ or not for 10 weeks. Quercetin alleviated HFD-induced histopathological changes, disorders of lipid metabolism, mitochondrial damage...
June 23, 2018: Molecular Nutrition & Food Research
Fernanda G D E Silva, Lisiery N Paiatto, Aureo T Yamada, Flavia M Netto, Patrícia U Simioni, Wirla M S C Tamashiro
SCOPE: In an attempt to develop new therapeutic treatments for colitis, we evaluated the effects of phenolic compounds and protein hydrolysates fractions of flaxseed on the in vitro production of pro-inflammatory mediators created by macrophages and on the course of experimental colitis. METHODS AND RESULTS: The anti-inflammatory effects of phenolic compounds (Phi) and protein hydrolysates (phr-FPH) from flaxseeds were studied in RAW264.7 cells and in TNBS colitis model...
June 22, 2018: Molecular Nutrition & Food Research
Adaobi Okonkwo, Joy Mitra, Gavin S Johnson, Li Li, Wan Mohaiza Dashwood, Muralidhar Hegde, Chen Yue, Roderick H Dashwood, Praveen Rajendran
SCOPE: DNA repair inhibitors have broad clinical applications in tumor types with DNA repair defects, including colorectal cancer. Structural analogs of the anticancer agent sulforaphane (SFN) were investigated as modifiers of histone deacetylase (HDAC) and histone acetyltransferase (HAT) activity, and for effects on DNA damage/repair pertinent to human colorectal cancer. METHODS AND RESULTS: In the polyposis in rat colon (Pirc) model, single oral administration of SFN and structurally-related long-chain isothiocyanates (ITCs) decreased HDAC3 expression and increased pH2AX levels markedly in adenomatous colon polyps, extending our prior observations on HDAC3 inhibition/turnover in cell-based assays...
June 20, 2018: Molecular Nutrition & Food Research
Yi-Hua Wang, Fansg Dai, Bo Zhou
SCOPE: As part of our research project in understanding why dietary polyphenols with the catechol skeleton tend to exhibit cancer chemopreventive activity, a catechol-type resveratrol analog (3,4-DHS) was selected to probe its antiangiogenic effects and mechanisms. METHODS AND RESULTS: We examined the antiangiogenic effects of 3,4-DHS on angiogenesis-related endothelial cell functions, including migration, invasion and tube formation, and in vivo angiogenesis on a chick chorioallantoic membrane assay...
June 20, 2018: Molecular Nutrition & Food Research
Alexia F P Lépine, Paul de Vos
SCOPE: Synbiotic effects of dietary fibers and lactobacilli are usually explained by synergistic modulation of gut-microbiota. New insight however has demonstrated that both dietary fibers and lactobacilli can directly stimulate immune cells and benefit consumer-immunity. Here we investigated synergistic effects of immune-active long-chain inulin (lcITF) and L. acidophilus W37 (LaW37) on dendritic cells (DCs). METHODS AND RESULTS: Effects of lcITF and LaW37 alone or combined were studied on Toll-like receptor (TLRs) signaling and cytokine secretion by DCs in the presence and absence of media of intestinal epithelial cell (IEC) exposed to the ingredients...
June 14, 2018: Molecular Nutrition & Food Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"