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Molecular Nutrition & Food Research

Silvia Barja-Fernandez, José María Moreno-Navarrete, Cintia Folgueira, Gemma Xifra, Mònica Sabater, Cecilia Castelao, Johan FernØ, Rosaura Leis, Carlos Diéguez, Felipe F Casanueva, Wifredo Ricart, Luisa M Seoane, José Manuel Fernandez-Real, Rubén Nogueiras
SCOPE: Angiopoietin-like protein 4 (ANGPTL-4) regulates plasma lipoprotein levels but its relevance in human obesity and type 2 diabetes is largely unknown. We aimed to investigate the regulation of circulating ANGPTL-4 levels in obesity, type 2 diabetes and after changes in body weight. METHODS AND RESULTS: Circulating ANGPTL-4 levels were measured in two different cohorts. First, in a cross-sectional study, we evaluated ANGPTL-4 levels in lean and obese patients with normoglycemia or with altered glucose tolerance (n = 282)...
March 14, 2018: Molecular Nutrition & Food Research
Laura A Calvo-Castro, Christina Schiborr, Franziska David, Heidi Ehrt, Jenny Voggel, Nadine Sus, Dariush Behnam, Anja Bosy-Westphal, Jan Frank
SCOPE: Grapevine-shoot extract Vineatrol® 30 contains abundant resveratrol monomers and oligomers with health-promoting potential. However, the oral bioavailability of these compounds in humans is low (˂1-2%). The aim of this study was to improve the oral bioavailability of resveratrol from vineatrol by micellar solubilization. METHODS AND RESULTS: Twelve healthy volunteers (6 women, 6 men) randomly ingested a single dose of 500 mg vineatrol (30 mg trans-resveratrol, 75 mg trans-ε-viniferin) as native powder or liquid micelles...
March 13, 2018: Molecular Nutrition & Food Research
Teresa Oliviero, Simone Lamers, Edoardo Capuano, Matthijs Dekker, Ruud Verkerk
SCOPE: Optimization of bioavailability of dietary bioactive health-beneficial compounds is as important as increasing their concentration in foods. The aim of this study was to explore the change in bioavailability of isothiocyanates in broccoli sprouts incorporated in protein, fibre and lipid gels. METHODS AND RESULTS: Five participants took part in a cross-over study and collected timed urine samples before up to 24-hours after consumption of proteins, dietary fibres and lipids gels containing broccoli spouts powder...
March 12, 2018: Molecular Nutrition & Food Research
Samantha L Martin, Kendra J Royston, Trygve O Tollefsbol
Cancer is the second leading cause of mortalities in the United States, only exceeded by heart disease. Current cancer treatments include chemotherapy, surgery and/or radiation. Due to the often harsh effects of current cancer therapies, investigators are focusing their efforts on cancer prevention mediated by dietary phytochemicals. Since the discovery that cancer can be initiated by and progress through both genetic and epigenetic pathways, there has been a significant surge in studies on epigenetic effects mediated by nutritive compounds...
March 12, 2018: Molecular Nutrition & Food Research
Maike Passon, Judith Bühlmeier, Benno F Zimmermann, Anja Stratmann, Stefan Latz, Peter Stehle, Rudolf Galensa
SCOPE: After intrinsic labeling of spinach (Spinacia oleracea L., Chenopodiaceae) with13 CO2 we investigated, if labeled polyphenol metabolites were detectable in human plasma. METHODS AND RESULT: In a pilot intervention trial five healthy men consumed 5 g freeze-dried13 C labeled spinach including a total amount of 160 μmol methoxyflavonols, including 70 μmol 5,3',4'-trihydroxy-3-methoxy-6,7-methylendioxyflavone-4'-glucuronide. Plasma samples of all subjects were analyzed with regard to their13 C/12 C ratio...
March 12, 2018: Molecular Nutrition & Food Research
Huiling Zhu, Haibo Wang, Shuhui Wang, Zhixiao Tu, Lin Zhang, Xiuying Wang, Yongqing Hou, Chunwei Wang, Jie Chen, Yulan Liu
SCOPE: Flaxseed oil is a rich source of α-linolenic acid (ALA), which is the precursor of the long-chain n-3 polyunsaturated fatty acids (PUFAs) including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). This study investigated the protective effect of flaxseed oil against intestinal injury induced by lipopolysaccharide (LPS). MATERIALS AND RESULTS: Twenty-four weaned pigs were used in a 2 × 2 factorial experiment with dietary treatment (5% corn oil vs...
March 6, 2018: Molecular Nutrition & Food Research
Mette Schmedes, Asker Daniel Brejnrod, Eli Kristin Aadland, Pia Kiilerich, Karsten Kristiansen, Hélène Jacques, Charles Lavigne, Ingvild Eide Graff, Øyvin Eng, Asle Holthe, Gunnar Mellgren, Jette Feveile Young, Ulrik Kraemer Sundekilde, Bjørn Liaset, Hanne Christine Bertram
SCOPE: The impact of dietary protein types on the gut microbiome is scarcely studied. The aim of the present study was therefore to examine the effects of lean-seafood and non-seafood proteins on the gut microbiome composition and activity and elucidate potential associations to cardiovascular disease (CVD) risk factors. METHODS: A cross-over intervention study in which 20 healthy subjects consumed two diets that varied in protein source was conducted.1 H NMR spectroscopy and 16S rDNA sequencing analyses were applied to characterize fecal metabolites and gut microbiota composition, respectively...
March 6, 2018: Molecular Nutrition & Food Research
Yung-Tsung Chen, Yu-Chun Lin, Jin-Seng Lin, Ning-Sun Yang, Ming-Ju Chen
SCOPE: Non-alcoholic fatty liver disease (NAFLD) is a common disease that is concomitant with obesity, resulting in increased mortality. To date, the efficiency of NAFLD treatment still needs to be improved. Therefore, we aimed to evaluate the effect of Lactobacillus mali APS1, which was isolated from sugary kefir, on hepatic steatosis in rats fed a high-fat diet (HFD). METHODS AND RESULTS: Sprague Dawley rats were fed a control diet, a high-fat diet with saline and a high-fat diet with APS1 intervention by gavage daily for 12 weeks...
March 5, 2018: Molecular Nutrition & Food Research
Soon-Hee Kim, Hee-Sook Park, Moon Ju Hong, Haeng Jeon Hur, Dae Young Kwon, Myung-Sunny Kim
SCOPE: This study investigated the effects of caffeic acid phenethyl ester (CAPE), a bioactive component of honeybee hives, on the prevention and treatment of metabolic syndrome (MetS) by comparing the efficacy of CAPE intake at the beginning of obesity and after obesity. The functional mechanism of CAPE was also investigated. METHODS AND RESULTS: C57BL/6 mice were fed a high-fat diet (HFD) containing 0.05% CAPE (HFD+C) for 12 weeks (HFD+C(Pre) group) or received HFD+C for 6 weeks after consuming the HFD for 6 weeks (HFD+C(Post) group)...
March 5, 2018: Molecular Nutrition & Food Research
Yongmei Yu, Tamra Mendoza, David Ribnicky, Alexander Poulev, Robert C Noland, Randall L Mynatt, Ilya Raskin, William T Cefalu, Z Elizabeth Floyd
SCOPE: The primary disorder underlying metabolic syndrome is insulin resistance due to excess body weight and abdominal visceral fat accumulation. In this study, we asked if dietary intake of an ethanolic extract from Russian tarragon (Artemisia dracunculus L., termed PMI5011), shown to improve glucose utilization by enhancing insulin signaling in skeletal muscle, could prevent obesity-induced insulin resistance, skeletal muscle metabolic inflexibility and ectopic lipid accumulation in skeletal muscle and liver...
February 23, 2018: Molecular Nutrition & Food Research
Jennifer Blaze, Jun Wang, Lap Ho, Natalia Mendelev, Fatemeh Haghighi, Giulio Maria Pasinetti
SCOPE: Stress is a known contributor to various forms of disease in humans and animals, although mechanisms are still unknown. In animals, psychosocial stress-induced depression/anxiety phenotypes are coincidental with increased inflammation in both brain and blood. We recently showed that a novel treatment with a select bioactive polyphenol preparation promotes resilience to stress-mediated depression/anxiety phenotypes mice. Moreover, we identified selective bioactive phenolic compounds within the polyphenol preparation that were effective in mitigating the behavioral effects of bone marrow transplantation from stressed mice...
February 22, 2018: Molecular Nutrition & Food Research
G Bhaskaragoud, V Geetha, T Sharanappa, A S Mohan Kumar, C Hema Kumar, G Suresh Kumar
SCOPE: Diabetic nephropathy (DN) is a micro-vascular complication of chronic diabetes. Sterol regulatory element binding protein1 (SREBP1) participation in the development of DN is reported. Oryzanol Concentrate (OC) at 0.1 and 0.3% was tested for its antioxidant and hypolipidemic effects. The aim of the work was to study the involvement of OC in the amelioration of DN in STZ induced diabetic animal model. METHODS AND RESULTS: Animals were grouped into Starch, High fat and OC treated control/diabetic groups (SFC/SFD, HFC/HFD, OFC/OFD)...
February 22, 2018: Molecular Nutrition & Food Research
Nadezda V Khodorova, Douglas N Rutledge, Marion Oberli, David Mathiron, Paulo Marcelo, Robert Benamouzig, Daniel Tomé, Claire Gaudichon, Serge Pilard
SCOPE: The impact of meat consumption on human health is widely examined in nutritional epidemiological studies, especially due to the connexion between the consumption of red and processed meat and the risk of colon cancer. Food questionnaires do not assess the exposure to different methods of meat cooking. This study aimed to identify biomarkers of the acute ingestion of bovine meat cooked with 2 different processes. METHODS AND RESULTS: Non-targeted UPLC-MS metabolite profiling was done on urine samples obtained from 24 healthy volunteers before and 8h after the ingestion of a single meal composed of intrinsically15 N labelled bovine meat, either cooked at 55 °C for 5 min or at 90 °C for 30 min...
February 22, 2018: Molecular Nutrition & Food Research
Min Pi, Karan Kapoor, Ruisong Ye, Jeremy C Smith, Jerome Baudry, L Darryl Quarles
SCOPE: The molecular mechanisms whereby gallates in green tea exert metabolic effects are poorly understood. METHODS AND RESULTS: We found that GPRC6A, a multi-ligand sensing G-protein coupled receptor that regulates energy metabolism, sex hormone production and prostate cancer progression, is a target for gallates. Sodium gallate,1 gallic acid (GA) > ethyl gallate (EG) > octyl gallate (OG) dose dependently activated ERK in HEK-293 cells transfected with GPRC6A but not in non-transfected controls...
February 21, 2018: Molecular Nutrition & Food Research
Jeong Hwan Oh, Eun-Young Kim, Taek-Jeong Nam
SCOPE: Glutamate-induced excitotoxicity involves in various neurodegenerative disorders. This study aimed to investigate whether a phycoerythrin-derived tryptic peptide of Pyropia yezoensis (PYP) reduces glutamate-induced excitotoxicity and neuronal senescence in primary rat hippocampal neurons. METHODS AND RESULTS: Glutamate exposure (100 μM) decreased cell viability and increased expression of endoplasmic reticulum (ER) stress response protein glucose-regulated protein 78 (GRP78) starting at 60 min following glutamate exposure, which was attenuated by PYP pretreatment (1 μg/mL)...
February 21, 2018: Molecular Nutrition & Food Research
Jonathan Isaak Kremer, Katharina Gömpel, Tamara Bakuradze, Gerhard Eisenbrand, Elke Richling
SCOPE: Coffee is a major natural source of niacin in the human diet, as it is formed during coffee roasting from the alkaloid trigonelline. The intention of our study was to monitor the urinary excretion of niacin metabolites after coffee consumption under controlled diet. METHODS AND RESULTS: We performed a four-day human intervention study on the excretion of major niacin metabolites in the urine of volunteers after ingestion of 500 mL regular coffee containing 34...
February 21, 2018: Molecular Nutrition & Food Research
Dushani L Palliyaguru, Jian-Min Yuan, Thomas W Kensler, Jed W Fahey
Isothiocyanates from cruciferous vegetables have been studied extensively in cells and in animals for their disease preventive and therapeutic effects. However, translating their utility to human populations has been both limited and challenging. Herein, clinical trials employing two isothiocyanates, sulforaphane (SFN; 1-Isothiocyanato-4-(methylsulfinyl) butane) and phenethyl isothiocyanate (PEITC; 2-isothiocyanatoethylbenzene) that are isolated principally from broccoli and watercress, respectively, are summarized and discussed...
February 21, 2018: Molecular Nutrition & Food Research
Shuang-Qing Zhang, Xue-Feng Yu, Hai-Bo Zhang, Ning Peng, Zhi-Xian Chen, Qian Cheng, Xiao-Li Zhang, Sui-Han Cheng, Yan Zhang
SCOPE: The oral absorption, distribution, excretion and bioavailability of zinc sulfate (ZnS), zinc gluconate (ZnG) and zinc-enriched yeast (ZnY) in rats were fully and systemically compared for the first time. METHODS AND RESULTS: After zinc compounds were orally administered to rats at a single dose of 4 mg Zn/kg, blood, tissues, urine and feces at different time points were collected for the quantification of zinc concentration. Blood was also harvested for the zinc assay in the multiple-dose administration...
February 19, 2018: Molecular Nutrition & Food Research
Sandra Tillmann, Hussain M Awwad, Amanda R Eskelund, Giulia Treccani, Juergen Geisel, Gregers Wegener, Rima Obeid
SCOPE: Probiotics may influence one-carbon (C1) metabolism, neurotransmitters, liver function markers, or behavior. METHODS AND RESULTS: Male adult Flinders Sensitive Line rats (model of depression, FSL; n = 22) received Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 (10 9 or 10 10 colony-forming units/d) or vehicle for 10 weeks. The controls, Flinders Resistant Line rats (FRL, n = 8), only received vehicle. C1-related metabolites were measured in plasma, urine, and different tissues...
February 17, 2018: Molecular Nutrition & Food Research
Haohai Huang, Ying Zou, Honggang Chi, Dan Liao
SCOPE: We performed a pooled analysis with trial sequential analysis (TSA) to evaluate the efficacy and safety of chitosan supplementation on serum lipids in humans. METHODS AND RESULTS: Medline, EMBASE and CENTRAL databases were queried. Impact was expressed as a weighted mean difference (WMD) and 95% confidence interval (CI). Sensitivity analysis was conducted using the leave-one-out method. Statistical heterogeneity, publication bias, TSA and subgroup analyses were also assessed...
February 16, 2018: Molecular Nutrition & Food Research
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