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Molecular Nutrition & Food Research

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https://www.readbyqxmd.com/read/28444960/in-vivo-absorption-and-metabolism-of-leptosperin-and-methyl-syringate-abundantly-present-in-manuka-honey
#1
Akari Ishisaka, Shinichi Ikushiro, Mie Takeuchi, Yukako Araki, Maki Juri, Yui Yoshiki, Yoshichika Kawai, Toshio Niwa, Noritoshi Kitamoto, Toshiyuki Sakaki, Hirohito Ishikawa, Yoji Kato
SCOPE: Manuka honey, which shows strong non-peroxide-dependent antibacterial activity, contains unique components, such as methyl syringate 4-O-β-D-gentiobioside (leptosperin) and its aglycone, methyl syringate (MSYR). To determine the potential for biological activity evoked by the ingestion of leptosperin and MSYR, we investigated the absorption and metabolism of these components in manuka honey. METHODS AND RESULTS: The incubation of MSYR with liver microsomes or S9 fractions in vitro resulted in the formation of MSYR-glucuronide (MSYR-GA), MSYR-sulfate (MSYR-S), and syringic acid as metabolites...
April 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28444884/novel-urinary-alkylresorcinol-metabolites-as-biomarkers-of-whole-grain-intake-in-free-living-swedish-adults
#2
Roksana Wierzbicka, Galia Zamaratskaia, Afaf Kamal-Eldin, Rikard Landberg
SCOPE: Most studies on the role of whole grain for health rely on self-reported intake data, which are prone to measurement errors. There is a need for dietary biomarkers that can provide an objective measure of intake. Alkylresorcinols (AR) and their main metabolites 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-propanoic acid (DHPPA) have been proposed as biomarkers for whole grain (WG) wheat and rye intake. METHODS AND RESULTS: The medium-term reproducibility and relative validity of four putative urinary AR metabolites (3,5-dihydroxycinnamic acid (DHCA), 5-(3,5-dihydroxyphenyl) pentanoic acid (DHPPTA), 2-(3,5-dihydroxybenzamido)acetic acid (DHBA-glycine) and 3,5-dihydroxycinnamic acid amide (DHCA-amide)) as biomarkers for WG intake were investigated...
April 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28440064/synthetic-and-analytical-strategies-for-the-quantification-of-phenyl-%C3%AE-valerolactone-conjugated-metabolites-in-human-urine
#3
Nicoletta Brindani, Pedro Mena, Luca Calani, Iris Benzie, Siu-Wai Choi, Furio Brighenti, Franca Zanardi, Claudio Curti, Daniele Del Rio
SCOPE: The contribution of the gut microbiota to the metabolism of catechins and proanthocyanidins remains unclear. Phenyl-γ-valerolactones have been identified as the most representative metabolites of these dietary flavan-3-ols, but their accurate quantification has posed problems because of a lack of appropriate bioanalytical standards. This work aimed at synthesizing a novel set of sulphate- and glucuronide-conjugated phenyl-γ-valerolactones and at developing an analytical platform using UHPLC-ESI-MS/MS for their quantification in urine...
April 25, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28436198/effects-of-selenium-on-apoptosis-and-abnormal-amino-acid-metabolism-induced-by-excess-fatty-acid-in-isolated-rat-hepatocytes
#4
Zhigang Zhang, Siyu Li, Huijie Jiang, Biying Liu, Zhanjun Lv, Changming Guo, Haili Zhang
SCOPE: Increased serum free fatty acid (FFA) occurs in subjects with non-alcoholic fatty liver disease (NAFLD) and also triggers oxidative stress, apoptosis, and insulin resistance. Selenium (Se) is an antioxidant agent. However, the effect of Se on NAFLD or diabetes is still unclear. We investigated the effect of Se on apoptosis and abnormal amino acid metabolism initiated by excess FFA in isolated rat hepatocytes. METHODS AND RESULTS: Primary hepatocytes from rats were isolated and exposed to excessive FFA (0...
April 24, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28421659/the-anti-inflammatory-effects-of-morin-hydrate-in-atherosclerosis-is-associated-with-autophagy-induction-through-camp-signaling
#5
Yue Zhou, Zhan-Qi Cao, Hong-Yuan Wang, Yan-Na Cheng, Lu-Gang Yu, Xin-Ke Zhang, Yan Sun, Xiu-Li Guo
SCOPE: Although the previous trials of inflammation have indicated that morin hydrate (MO) hold considerable promise, understanding the distinct mechanism of MO against inflammation remains a challenge. METHODS AND RESULTS: This study investigated the effect of MO in atherosclerosis in ApoE(-/-) mice and underlying cell signaling of MO effect in inflammation in human umbilical vein endothelial cells (HUVECs). Administration of MO significantly reduced serum lipid level, inflammatory cytokines (TNF-α and ICAM-1) and atherosclerotic plaque formation in vivo...
April 18, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28393456/blackcurrant-anthocyanins-modulate-ccl11-secretion-and-suppress-allergic-airway-inflammation
#6
Odette M Shaw, Tafadzwa Nyanhanda, Tony K McGhie, Jacquie L Harper, Roger D Hurst
CCL11, a chemokine, is linked to the early development of airways eosinophilia in allergic asthma. Therefore, CCL11 production is a target for abrogating eosinophilic-driven airway inflammation. Blackcurrants are high in compounds that regulate inflammation, particularly anthocyanins. In this study we investigated the effect of oral blackcurrant supplementation on allergen-induced eosinophilia and CCL11 production; we also profiled key compounds in blackcurrants that were linked to this effect. 10 mg/kg (total anthocyanins) of a commercially available, anthocyanin-rich New Zealand 'Ben Ard' blackcurrant extract ('Currantex 30') attenuated ovalbumin-induced inflammation, eosinophilia (by 52...
April 9, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28371298/the-mediterranean-diet-decreases-ldl-atherogenicity-in-high-cardiovascular-risk-individuals-a-randomized-controlled-trial
#7
Álvaro Hernáez, Olga Castañer, Alberto Goday, Emilio Ros, Xavier Pintó, Ramón Estruch, Jordi Salas-Salvadó, Dolores Corella, Fernando Arós, Lluis Serra-Majem, Miguel Ángel Martínez-González, Miquel Fiol, José Lapetra, Rafael de la Torre, M Carmen López-Sabater, Montserrat Fitó
SCOPE: Traditional Mediterranean Diet (TMD) protects against cardiovascular disease through several mechanisms such as decreasing LDL cholesterol levels. However, evidence regarding TMD effects on LDL atherogenic traits (resistance against oxidation, size, composition, cytotoxicity) is scarce. METHODS AND RESULTS: We assessed the effects of a 1-year intervention with a TMD on LDL atherogenic traits in a random sub-sample of individuals from the PREDIMED Study (N = 210)...
April 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28371117/structural-constraints-and-importance-of-caffeic-acid-moiety-for-anti-hyperglycemic-effects-of-caffeoylquinic-acids-from-chicory
#8
Kimberly M Palatini Jackson, Thirumurugan Rathinasabapathy, Debora Esposito, Slavko Komarnytsky
SCOPE: Chicory (Cichorium intybus L.) is a perennial herb often consumed as a vegetable, whereas the ground and roasted roots are blended as a coffee substitute. Caffeoylquinic or chlorogenic acids (CQA), the abundant intermediates of lignin biosynthesis in chicory, have been reported to improve glucose metabolism in humans, but the functional group in their structure responsible for this effect has not been yet characterized. METHODS AND RESULTS: Here, we showed that three di-O-caffeoylquinic acids suppressed hepatic glucose production in H4IIE rat hepatoma cells by reducing expression of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), two key enzymes that regulate hepatic gluconeogenesis...
April 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28371338/oral-administration-of-nasturtium-affects-peptide-yy-secretion-in-male-subjects
#9
Sonja Schiess, Stefanie Platz, Margrit Kemper, Monika Schreiner, Inga Mewis, Sascha Rohn, Christiane Bumke-Vogt, Olga Pivovarova, Andreas F H Pfeiffer
SCOPE: Nasturtium plants contain the glucosinolate glucotropaeolin and its corresponding breakdown product benzyl isothiocyanate (BITC), the latter being intensively studied with regard to cancer chemoprevention and anti-inflammatory properties. In addition, recent research has shown that isothiocyanates are able to activate the release of several gut hormones in vitro and in rodent studies. Here, we tested the effects of a dietary nasturtium administration on circulating levels of gut hormones in humans...
March 31, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28371322/alliin-a-garlic-organosulfur-compound-ameliorates-gut-inflammation-through-mapk-nf-%C3%AE%C2%BAb-ap-1-stat-1-inactivation-and-ppar%C3%AE-activation
#10
Limin Shi, Qinlu Lin, Xinhua Li, Ying Nie, Shuguo Sun, Xiyun Deng, Long Wang, Jun Lu, Yiping Tang, Feijun Luo
OBJECTIVE: In this study, the anti-inflammatory effects and the molecular mechanism of alliin were analyzed in dextran sulfate sodium (DSS)-induced colitis mice and lipopolysaccharide-stimulated RAW264.7 cell model. METHODS: The phenotype of mice was recorded in the DSS-induced and/or alliin (500 mg/kg) groups. Histopathological alterations were analyzed by H&E staining. MPO and MDA of colon tissues were measured. The mRNA expression levels of inflammatory factors were determined by qRT-PCR, and protein expressions of inflammatory factors or activation of kinases were determined by Western blotting...
March 30, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28371258/n-3-polyunsaturated-fatty-acids-increase-hepatic-fibroblast-growth-factor-21-sensitivity-via-a-ppar%C3%AE-%C3%AE-klotho-pathway
#11
Wenqi Yang, Xu Chen, Yan Liu, Ming Chen, Xinwei Jiang, Tianran Shen, Qing Li, Yan Yang, Wenhua Ling
SCOPE: Fibroblast growth factor 21 (FGF21) participated in fish oil-mediated hepatic lipid-regulation and anti-inflammatory effects in high-fat diet fed-mice. However, fish oil supplementation did not significantly increase FGF21 protein levels. Whether fish oil-induced benefits in the liver are related to hepatic FGF21 sensitivity remains unclear. METHODS AND RESULTS: Male C57BL/6J mice were fed a low-fat diet (LFD), a high-fat diet (HFD) or a fish oil-supplemented high-fat diet (FOD) for 12 weeks...
March 30, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28370954/citrus-flavonoid-naringenin-reduces-mammary-tumor-cell-viability-adipose-mass-and-adipose-inflammation-in-obese-ovariectomized-mice
#12
Jia-Yu Ke, Taylor Banh, Yung-Hsuan Hsiao, Rachel M Cole, Shana R Straka, Lisa D Yee, Martha A Belury
SCOPE: Obesity-related metabolic dysregulation may be a link between obesity and postmenopausal breast cancer. Naringenin, a flavonoid abundant in grapefruits, displays beneficial effects on metabolic health and tumorigenesis. Here, we assessed the effects of naringenin on mammary tumor cell growth in vitro and in obese ovariectomized mice. METHODS AND RESULTS: Naringenin inhibited cell growth, increased phosphorylation of AMP-activated protein kinase (AMPK), down-regulated CyclinD1 expression, and induced cell death in E0771 mammary tumor cells...
March 30, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28371380/dietary-fat-content-modulates-the-hypolipidemic-effect-of-dietary-inulin-in-rats
#13
Kyu-Ho Han, Aiko Yamamoto, Ken-Ichiro Shimada, Hiroto Kikuchi, Michihiro Fukushima
SCOPE: Dietary fat content (low versus high fat) may modulate the serum lipid-lowering effect of high-performance (HP)-inulin. This study investigated the effect of dietary HP-inulin on metabolism in rats fed a low- or high-fat diet. METHODS AND RESULTS: Rats were fed a diet of 5% fat with 5% cellulose or 5% HP-inulin (average degree of polymerization = 24) (low-fat diet) or of 20% fat with 5% cellulose or 5% HP-inulin (high-fat diet) for 28 days. Total, HDL, and non-HDL cholesterols, and triglyceride concentrations in the serum were measured along with total lipid content of liver and feces...
March 29, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28333398/dietary-cholesterol-interacts-with-srebf1-to-modulate-obesity-in-chinese-children
#14
Shixiu Zhang, Xinying Lin, Henry Lynn, Guifa Xu, Jun Li, Changfeng Zhao, Mingmei Li
SCOPE: Sterol Regulatory Element Binding Protein 1 Gene (SREBF1) is an important candidate gene for obesity that could be affected by cholesterol. Different SREBF1 gene variants may have distinct responses to cholesterol, leading to different risks for obesity and obesity-related metabolic traits. Thus, we performed a gene-by-diet correlation analysis to test whether SREBF1 gene variation modulate the relationship between cholesterol and obesity. METHODS AND RESULTS: A total of 642 school-aged children in Jinan, China, were selected by stratified cluster nested sampling...
March 23, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28324642/cinnamon-reduces-inflammatory-response-in-intestinal-fibroblasts-in-vitro-and-in-colitis-in-vivo-leading-to-decreased-fibrosis
#15
Yvonne Hagenlocher, Sabrina Satzinger, Mehtap Civelek, Katharina Feilhauer, Jörg Köninger, Stephan C Bischoff, Axel Lorentz
Intestinal fibrosis, a complication of inflammatory bowel disease, is currently being addressed by surgery alone, with no adequate alternative therapy available for patients. We propose that anti-inflammatory plant substances like cinnamon extract (CE) or its main compound cinnamaldeyde (CA) could aid in therapy. We recently found CE reducing inflammation in murine colitis. Here, we analysed effects of CE on fibrosis in IL-10(-/-) colitis METHODS AND RESULTS: IL-10(-/-) and wild type (wt) mice were orally treated with/without vehicle or CE...
March 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28322000/postprandial-triglyceride-rich-lipoproteins-promote-lipid-accumulation-and-apolipoprotein-b-48-receptor-transcriptional-activity-in-human-circulating-and-murine-bone-marrow-neutrophils-in-a-fatty-acid-dependent-manner
#16
Almudena Ortega-Gómez, Lourdes M Varela, Sergio Lopez, Sergio Montserrat de la Paz, Rosario Sanchez, Francisco J G Muriana, Beatriz Bermúdez, Rocío Abia
SCOPE: Postprandial triglyceride-rich lipoproteins (TRLs) promote atherosclerosis. Recent research points the bone marrow (BM) as a primary site in atherosclerosis. We elucidated how the acute administration of MUFAs, omega-3 PUFAs and saturated fatty acids (SFAs) affects human circulating and murine BM neutrophil lipid accumulation and functionality. METHODS AND RESULTS: Postprandial hypertriglyceridemia was induced in healthy subjects and Apoe-/- mice by the acute administration of dietary fats enriched in MUFAs, PUFAs or SFAs...
March 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28319651/mediterranean-tomato-based-sofrito-protects-against-vascular-alterations-in-obese-zucker-rats-by-preserving-no-bioavailability
#17
Rosalia Rodriguez-Rodriguez, Francesc Jiménez-Altayó, Laia Alsina, Yara Onetti, Jose F de Alvarenga, Carmen Claro, Elena Ogalla, Nuria Casals, Rosa M Lamuela-Raventos
SCOPE: Sofrito, a key component of the Mediterranean diet, provides nutritional interest due to its high content in bioactive compounds from tomato and olive oil, and especially to the lipid matrix in which these compounds are found. In this study, the potential beneficial effects of dietary intake of sofrito on obesity-related vascular alterations were explored in obese Zucker rats. METHODS AND RESULTS: Obese and lean rats were fed a control diet supplemented or not with 2% (w/w) sofrito for 8 weeks...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28319645/the-atypical-genesis-and-bioavailability-of-the-plant-based-small-rna-mir2911-bulking-up-while-breaking-down
#18
Jian Yang, Natee Kongchan, Cecilia Primo Planta, Joel R Neilson, Kendal D Hirschi
SCOPE: The uptake of dietary plant small RNAs (sRNAs) in consumers remains controversial, which is mainly due to low dietary content in combination with poor fractional absorption. MIR2911, among all the plant sRNAs including microRNAs, has been shown to be one of the most robustly absorbed sRNAs. Here we analyze the unusual abundance and unique genesis of MIR2911 during vegetable processing. METHODS AND RESULTS: Using qRT-PCR, the abundance of MIR2911 increased dramatically in macerated tissues while other microRNAs degraded...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28318108/neonatal-mono-colonization-of-germ-free-mice-with-lactobacillus-casei-enhances-casein-immunogenicity-after-oral-sensitization-to-cow-s-milk
#19
Matieny Aicha Maiga, Stéphanie Morin, Hervé Bernard, Sylvie Rabot, Karine Adel -Patient, Stéphane Hazebrouck
SCOPE: Food allergy is an increasing global health problem and perinatal administration of probiotic bacteria is currently under investigation in order to prevent the development of allergic diseases. Here, we investigated the impact of neonatal mono-colonization of mice with Lactobacillus casei BL23 on an oral sensitization to cow's milk. METHODS AND RESULTS: Mono-colonized (LC) mice were obtained by inoculating L. casei to germ-free (GF) parents. Nine-week-old GF, LC and conventional (CV) mice were orally sensitized to cow's milk with cholera toxin as adjuvant...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28318092/lycopene-and-risk-of-cardiovascular-diseases-a-meta-analysis-of-observational-studies
#20
Bo Song, Kai Liu, Yuan Gao, Lu Zhao, Hui Fang, Yusheng Li, Lulu Pei, Yuming Xu
SCOPE: The aim of current meta-analysis was to investigate the relation between lycopene and risk of cardiovascular diseases (CVD). METHODS AND RESULTS: Studies concerning about the association between lycopene and risk of CVD were searched on Pubmed, Embase, and Web of Science from inception to October 2016. A total of 14 eligible studies were identified. A significantly inverse association with a pooled risk ratio (RR) of 0.83 (95% CI: 0.76-0.90) was shown between lycopene exposure and risk of CVD...
March 20, 2017: Molecular Nutrition & Food Research
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