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Molecular Nutrition & Food Research

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https://www.readbyqxmd.com/read/28812326/effect-of-dietary-components-from-antarctic-krill-on-atherosclerosis-in-apoe-deficient-mice
#1
Cinzia Parolini, Bodil Bjorndal, Marco Busnelli, Stefano Manzini, Giulia S Ganzetti, Federica Dellera, Marie Ramsvik, Inge Bruheim, Rolf Kristian Berge, Giulia Chiesa
SCOPE: Antarctic krill is a great source of n-3 fatty acids and high-quality proteins. Aim of the study was to evaluate the effect of Antarctic krill components on plasma lipids and atherosclerosis development. METHODS AND RESULTS: Sixty apoEKO mice were divided into four groups and fed Western diet (CONTROL) or Western-like diets, differing for protein or fat content. Specifically, casein or fat in CONTROL was partially replaced by krill proteins (PRO), krill oil (KRILL OIL), or both (KRILL OIL+PRO)...
August 15, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28801966/ursolic-acid-a-natural-nutraceutical-agent-targets-caspase3-and-alleviates-inflammation-associated-downstream-signal-transduction
#2
Xiaoyao Ma, Yuan Zhang, Zengyong Wang, Yunbing Shen, Man Zhang, Quandeng Nie, Yuanyuan Hou, Gang Bai
SCOPE: Ursolic acid (UA) is a pentacyclicterpenoid carboxylic acid that is present in a wide variety of plant foods. There are many beneficial health effects that are attributed to the properties of UA. However, the specific cellular targets of UA and the mechanism underlying downstream signal transduction processes linked to the anti-inflammation pathway have not been thoroughly elucidated to date. METHODS AND RESULTS: Chemical biology strategies such as target fishing, click reaction synthesis of a UA probe and molecular imaging were used to identify potential target proteins of UA...
August 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28799714/potential-biological-effects-of-epigallocatechin-3-gallate-on-the-treatment-of-nonalcoholic-fatty-liver-disease
#3
REVIEW
Cheng Chen, Qian Liu, Lin Liu, Yi-Yang Hu, Qin Feng
Nonalcoholic fatty liver disease (NAFLD) is a major health issue throughout the world. However, no validated treatments for NAFLD are currently available. In-depth studies have demonstrated the efficacy of (-)-epigallocatechin-3-gallate (EGCG), a main bioactive chemical extracted from green tea, in treating NAFLD. EGCG exhibits multi-pronged preventive and therapeutic activities, including promoting lipid and glucose metabolism, anti-lipid peroxidation and anti-inflammation activities, anti-fibrosis, and anti-NAFLD related tumor, thus contributing to the mitigation of NAFLD occurrence and progression...
August 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28795489/plasma-metabolomics-reveals-steroidal-alkaloids-as-novel-biomarkers-of-tomato-intake-in-mice
#4
Morgan J Cichon, Ken M Riedl, Lei Wan, Jennifer M Thomas-Ahner, David M Francis, Steven K Clinton, Steven J Schwartz
SCOPE: Diets rich in tomato products are associated with a reduced risk of various chronic disease processes. The carotenoid lycopene is most intensely studied as the bioactive mediating health effects, yet tomatoes contain an array of phytochemicals. We conducted an untargeted metabolomics study on blood plasma to identify novel markers of tomato consumption absorbed from the diet and released into the bloodstream in mice. METHODS AND RESULTS: Male mice were fed a control AIN-93G diet or the same diet supplemented with 0...
August 9, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28786558/ser71-of-%C3%AE-s1-casein-is-phosphorylated-in-breast-milk-evidence-from-targeted-mass-analysis
#5
Simone König, Irina Altendorfer, Thorsten Saenger, Ellen Bleckb Stefan Vordenbäumen, Matthias Schneider, Joachim Jose
SCOPE: The casein phosphoproteins in mother's milk supply calcium and phosphate ions and make them biologically available to the newborn. Human αS1-casein is of particular interest being also an autoantigen and proinflammatory cytokine. Phosphorylation of αS1-casein by casein kinase 2 completely abolishes binding to toll-like receptor 4 and proinflammatory effects. It is, however, not known, which amino acids are affected. Therefore, we analyzed breast milk samples in an effort to detect the phosphorylation sites of αS1-casein...
August 8, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28766852/serotonin-transporter-promoter-polymorphism-modulates-the-ability-to-control-food-intake-effect-on-total-weight-loss
#6
Gemma Bonnet, Purificación Gómez-Abellán, Beatriz Vera, Juan Francisco Sánchez-Romera, Antonio M Hernández-Martínez, Silvia Sookoian, Carlos Jose Pirola, Marta Garaulet
SCOPE: The biggest challenge for losing weight is the ability to control the amount of food eaten; the tendency to overeat is called disinhibition. Our aims were to determine whether a) the SLC6A4-promoter variant (5-HTTLPR) relates to disinhibition; b) this association could affect total weight-loss during a behavioral/dietary treatment for obesity. METHODS AND RESULTS: 2961 subjects attended voluntarily five weight-loss clinics; a subsample (n = 624) was recruited for SLC6A4 genotyping...
August 2, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28759161/serine-alleviates-oxidative-stress-via-supporting-glutathione-synthesis-and-methionine-cycle-in-mice
#7
Xihong Zhou, Liuqin He, Canrong Wu, Yumei Zhang, Xin Wu, Yulong Yin
SCOPE: serine lies at the central node linking biosynthetic flux from glycolysis to glutathione synthesis and one-carbon metabolic cycle which are closely related to antioxidant capacity. The present study was conducted to determine the effects of serine supplementation on oxidative stress and its relative mechanisms. METHODS AND RESULTS: diquat treatment was performed to induce oxidative stress in mice and primary hepatocytes. The results showed that hepatic glutathione anti-oxidant systems were impaired and reactive oxygen species and homocysteine were increased in diquat-induced mice and hepatocytes, while such disadvantageous changes were diminished by serine supplementation both in vivo and in vitro...
July 31, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28759152/anthocyanins-from-purple-corn-ameliorated-tnf-%C3%AE-induced-inflammation-and-insulin-resistance-in-3t3-l1-adipocytes-via-activation-of-insulin-signaling-and-enhanced-glut4-translocation
#8
Diego Luna-Vital, Matthew Weiss, Elvira Gonzalez de Mejia
SCOPE: The aim was to compare the effect of an anthocyanin-rich extract from purple corn pericarp (PCW) and pure anthocyanins on adipogenesis, inflammation and insulin resistance in 3T3-L1 adipocytes on basal and inflammatory conditions. METHODS AND RESULTS: Preadipocytes (3T3-L1) were treated during differentiation with or without PCW. Differentiated adipocytes were treated either individually or in combination with tumor necrosis factor TNF-α and PCW, or pure C3G, Pg3G, P3G...
July 31, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28758352/fast-digestive-leucine-rich-soluble-milk-proteins-improve-muscle-protein-anabolism-and-mitochondrial-function-in-undernourished-old-rats
#9
Jérôme Salles, Audrey Chanet, Alexandre Berry, Christophe Giraudet, Véronique Patrac, Carla Domingues-Faria, Christophe Rocher, Christelle Guillet, Philippe Denis, Corinne Pouyet, Cécile Bonhomme, Pascale Le Ruyet, Yves Rolland, Yves Boirie, Stéphane Walrand
SCOPE: One strategy to manage malnutrition in older patients is to increase protein and energy intake. Here we evaluate the influence of protein quality during refeeding on improvement in muscle protein and energy metabolism. METHODS AND RESULTS: Twenty-month-old male rats (n = 40) were fed 50% of their spontaneous intake for 12 weeks to induce malnutrition, then refed ad libitum with a standard diet enriched with casein or soluble milk proteins (22%) for 4 weeks...
July 31, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28755411/associations-of-current-diet-with-plasma-and-urine-tmao-in-the-karmen-study-direct-and-indirect-contributions
#10
Ralf Krüger, Benedikt Merz, Manuela J Rist, Paola G Ferrario, Achim Bub, Sabine E Kulling, Bernhard Watzl
SCOPE: Knowledge on the influence of current diet on TMAO levels in humans is still inconsistent. Thus, we aimed to investigate associations of current diet with urine and plasma TMAO levels and to determine the effect of different foods on TMAO variation. METHODS AND RESULTS: TMAO concentrations of 297 healthy individuals were assessed using (1) H-NMR spectroscopy for 24h urine collection and spot urine, and LC-MS for plasma. Of 35 assessed food groups, those with a correlation of ρ >|0...
July 29, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28755406/effect-of-apple-polyphenols-on-vascular-oxidative-stress-and-endothelium-function-a-translational-study
#11
Arrigo F G Cicero, Cristiana Caliceti, Federica Fogacci, Marina Giovannini, Donato Calabria, Alessandro Colletti, Maddalena Veronesi, Aldo Roda, Claudio Borghi
SCOPE: We aimed examining apple polyphenols' effect on uricemia and endothelial function in a sample of overweight subjects. METHODS AND RESULTS: This was a two-phases study. In vitro experiment aimed to evaluate apple polyphenols' ability to lower uric acid in comparison with allopurinol. In vivo study consisted in a randomized, double-blind, parallel placebo-controlled clinical trial involving 62 overweight volunteers with suboptimal values of fasting plasma glucose (100mg/dL≤FPG≤125mg/dL), randomized to 300mg apple polyphenols or placebo for 8 weeks...
July 29, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28752930/oral-administration-of-grifola-frondosa-polysaccharides-improves-memory-impairment-in-aged-rats-via-antioxidant-action
#12
Zhaoxia Chen, Yanan Tang, Along Liu, Xiaobao Jin, Jiayong Zhu, Xuemei Lu
SCOPE: Grifola frondosa is an edible/medicinal mushroom with great nutritional value and bioactivity. The present study was performed to evaluate the beneficial effect of polysaccharides isolated from Grifola frondosa on memory impairment in aged rats. METHODS AND RESULTS: 20-month-old rats were gavaged with Grifola frondosa polysaccharides (GFP) for 8 weeks. Morris Water Maze test revealed that GFP administration significantly improved memory impairment in aged rats...
July 28, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28752563/differential-intestinal-anti-inflammatory-effects-of-lactobacillus-fermentum-and-lactobacillus-salivarius-in-dss-mouse-colitis-impact-on-micrornas-expression-and-microbiota-composition
#13
Alba Rodríguez-Nogales, Francesca Algieri, Jose Garrido-Mesa, Teresa Vezza, M Pilar Utrilla, Natalia Chueca, Federico Garcia, Mónica Olivares, M Elena Rodríguez-Cabezas, Julio Gálvez
SCOPE: To compare the intestinal anti-inflammatory effects of two probiotics Lactobacillus fermentum and Lactobacillus salivarius in mouse colitis, focusing on their impact on selected miRNAs and microbiota composition. METHODS AND RESULTS: Male C57BL/6J mice were randomly assigned to four groups (n = 10): non-colitic, DSS colitic and two colitic groups treated with probiotics (5 × 10(8) CFU/mouse/day). Both probiotics ameliorated macroscopic colonic damage. They improved the colonic expression of markers involved in the immune response, and the expression of miR-155 and miR-223...
July 28, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28752528/folic-acid-modulates-cancer-associated-micro-rnas-and-inflammatory-mediators-in-neoplastic-and-non-neoplastic-colonic-cells-in-a-different-way
#14
Birgit Niemann, Anke Nemitz, Josephine Werner, Ha Dong Mai, Pablo Steinberg, Alfonso Lampen, Anke Ehlers
SCOPE: Scientific evidence suggests that folic acid (FA) supplementation protects the healthy colonic mucosa from neoplastic transformation but may promote the progression of precancerous lesions. The underlying molecular mechanisms are not fully understood. Therefore, we explored, if high physiological FA doses provoke changes in (i) promoter-specific DNA methylation (ii) expression of cancer-associated micro RNAs (miRNAs) and (iii) inflammatory mediators in human neoplastic and non-neoplastic colonic cell lines...
July 28, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28741856/relationship-between-vitamin-d-and-gestational-diabetes-in-overweight-or-obese-pregnant-women-may-be-mediated-by-adiponectin
#15
Aya Mousa, Sally K Abell, Soulmaz Shorakae, Cheryce L Harrison, Negar Naderpoor, Danielle Hiam, Alba Moreno-Asso, Nigel K Stepto, Helena J Teede, Barbora de Courten
SCOPE: Maternal vitamin D deficiency has been implicated in adverse pregnancy outcomes. However, the association between vitamin D and inflammation, particularly adipokines, remains unexplored in pregnancy. METHODS AND RESULTS: In 102 overweight or obese pregnant women at high-risk of gestational diabetes (GDM), we investigated relationships between maternal 25-hydroxyvitamin D (25(OH)D) concentrations at 12-15 weeks gestation (baseline) and serum lipids, inflammatory markers, novel adipokines (omentin-1, visfatin, high molecular weight (HMW)-adiponectin), and subsequent pregnancy outcomes (GDM, preeclampsia, preterm birth PTB])...
July 25, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28736992/microbiota-metabolome-and-immune-alterations-in-obese-mice-fed-a-high-fat-diet-containing-type-2-resistant-starch
#16
Javad Barouei, Zach Bendiks, Alice Martinic, Darya Mishchuk, Dustin Heeney, Yu-Hsin Hsieh, Dorothy Kieffer, Jose Zaragoza, Roy Martin, Carolyn Slupsky, Maria L Marco
SCOPE: We examined the intestinal and systemic responses to incorporating a type 2 resistant starch (RS) into a high fat diet fed to obese mice. METHODS AND RESULTS: Diet-induced obese, C57BL/6J mice were fed a HF diet without or with 20% (by weight) high-amylose maize resistant starch (HF-RS) for six weeks. Serum adiponectin levels were higher with RS consumption, but there were no differences in weight gain and adiposity. With HF-RS, the expression levels of ileal TLR2 and Reg3g and cecal occludin, TLR2, TLR4, NOD1 and NOD2 were induced; whereas colonic concentrations of the inflammatory cytokine IL-17A declined...
July 24, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28734036/-epicatechin-regulates-blood-lipids-and-attenuates-hepatic-steatosis-in-rats-fed-high-fat-diet-%C3%A2
#17
Hui Cheng, Na Xu, Wenxia Zhao, Jingjing Su, Mengru Liang, Zhongwen Xie, Xianli Wu, Qinglin Li
SCOPE: (-)-Epicatechin (EC) is a natural flavanol monomer found in cocoa, green tea and a variety of other plant foods. In this study, effects of EC on blood lipids and hepatic steatosis, and the underlying mechanisms were investigated. METHODS AND RESULTS: A hyperlipidemic rat model was induced by high-fat, high-cholesterol diet. EC was then administrated to the animals by gavage at doses of 10 mg/kg, 20 mg/kg, 40 mg/kg body weight (BW) for 12 weeks. Simvastatin was included as a positive control...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28734033/genistein-and-enterolactone-in-relation-to-ki-67-expression-and-her2-status-in-postmenopausal-breast-cancer-patients
#18
Stefanie Jaskulski, Audrey Y Jung, Anja Rudolph, Theron Johnson, Kathrin Thöne, Esther Herpel, Peter Sinn, Jenny Chang-Claude
SCOPE: Phytoestrogens (PE) may improve breast cancer prognosis by modifying tumor prognostic markers, such as cell proliferation marker Ki-67 and human epidermal growth factor receptor 2 (HER2). Epidemiological evidence linking lignans and isoflavones to Ki-67 and HER2 is limited. We examined associations between the major metabolites of lignans and isoflavones - enterolactone (ENL) and genistein (GEN) - respectively, and Ki-67 expression and HER2 in tumor tissue of breast cancer patients...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28731263/commercial-strain-derived-clinical-saccharomyces-cerevisiae-can-evolve-new-phenotypes-without-higher-pathogenicity
#19
Walter P Pfliegler, Enikő Boros, Kitti Pázmándi, Ágnes Jakab, Imre Zsuga, Renátó Kovács, Edit Urbán, Zsuzsa Antunovics, Attila Bácsi, Matthias Sipiczki, László Majoros, István Pócsi
SCOPE: Saccharomyces cerevisiae is one of the most important microbes in food industry, but there is growing evidence on its potential pathogenicity as well. Its status as a member of human mycobiome is still not fully understood. METHODS AND RESULTS: In this study, we characterise clinical S. cerevisiae isolates from Hungarian hospitals along with commercial baking and probiotic strains, and determine their phenotypic parameters, virulence factors, interactions with human macrophages, and pathogenicity...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28731213/immunomodulatory-properties-of-olea-europaea-leaf-extract-in-intestinal-inflammation
#20
Teresa Vezza, Francesca Algieri, Alba Rodríguez-Nogales, José Garrido-Mesa, M Pilar Utrilla, Nassima Talhaoui, Ana María Gómez-Caravaca, Antonio Segura-Carretero, M Elena Rodríguez-Cabezas, Giovanni Monteleone, Julio Gálvez
SCOPE: Extracts from olive (Olea europaea) leaves are used in Mediterranean traditional medicine as anti-inflammatory. They contain antioxidant phenolic compounds, like oleuropeoside, which could be interesting for the treatment of inflammatory conditions associated with oxidative stress in humans, including inflammatory bowel disease. METHODS AND RESULTS: The anti-inflammatory effects of olive leaf extract (0.5-25 mg/kg) were studied in two mice models of colitis (DSS and DNBS)...
July 21, 2017: Molecular Nutrition & Food Research
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