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Molecular Nutrition & Food Research

Eva Fuglsang, Lukasz Krych, Mia Thorup Lundsager, Dennis Sandris Nielsen, Hanne Frøkiaer
SCOPE: This study addressed whether administration of Lactobacillus rhamnosus HN001 could mitigate the effects of a compromised gut microbiota on the composition of mature leukocytes and granulocyte-macrophage progenitor cells (GMPs) in newborn mice. METHODS AND RESULTS: Pregnant dams received oral broad-spectrum antibiotics, which dramatically decreased the gut microbial composition analyzed by 16S rRNA sequencing. Perinatal antibiotic treatment decreased the proportions of bone marrow (BM) GMPs (postnatal day (PND2): 0...
September 13, 2018: Molecular Nutrition & Food Research
Ulrike Seidel, Patricia Huebbe, Gerald Rimbach
Taurine is a non-proteinogenic ß-aminosulfonic acid. Important dietary sources of taurine are fish and seafood. Taurine interacts with ion channels, stabilizes membranes and regulates the cell volume. These actions confirm its high concentrations in excitable tissues like retina, neurons and muscles. Retinal degeneration, cardiomyopathy as well as skeletal muscle malfunction are evident in taurin e deficient phenotypes. There is evidence that taurine counteracts lipid peroxidation and increases cellular antioxidant defense in response to inflammation...
September 13, 2018: Molecular Nutrition & Food Research
Qixing Nie, Haihong Chen, Jielun Hu, He Gao, Linlin Fan, Zhimin Long, Shaoping Nie
SCOPE: Type 2 diabetes is a complex metabolic and endocrine disorder worldwide, which causes severe health and economic problems. The aim of this study was to investigate the molecular mechanisms by which arabinoxylan from Plantago asiatica L. attenuates type 2 diabetes from perspective of urine metabolomics. METHODS AND RESULTS: High-fat diet and streptozotocin-induced type 2 diabetic rats were treated with arabinoxylan, then the urine samples were collected for untargeted metabolomics analysis by UPLC-Triple-TOF/MS...
September 13, 2018: Molecular Nutrition & Food Research
Haiqin Wu, Lulu Ye, Xiaoxi Lu, Shuang Xie, Qian Yang, Qinghua Yu
SCOPE: The intestinal mucosal barrier, including the mucus layer, protects against invasion of enteropathogens, thereby inhibiting infection. In this study, the protective effect of Lactobacillus on intestinal barrier against Salmonella infection was investigated. The underlying mechanism of its effect, specifically on regulation of goblet cells through Notch pathway, was also elucidated. METHODS AND RESULTS: Here, we explored the protective effect of Lactobacillus on alleviating changes in the intestinal barrier caused by Salmonella infection...
September 10, 2018: Molecular Nutrition & Food Research
Shigenobu Matsumura, Fuka Ishikawa, Tsutomu Sasaki, Mayuki Odanaka, Mark Christian C Manio, Tohru Fushiki, Kazuo Inoue
SCOPE: Previously, we found that corn oil ingestion activated both the gustatory system and brain reward system stimulating motivation for eating. In the present study, we investigated the effect of voluntary corn oil ingestion on body weight gain and energy metabolism in mice. METHODS AND RESULTS: Voluntary corn oil ingestion with normal chow feeding did not lead to higher body weight than that of only the chow-fed control group. Mice that ingested corn oil had a higher total caloric intake and energy expenditure than did mice in the control group...
September 7, 2018: Molecular Nutrition & Food Research
Catherine Potter, Anthony Vincent Moorman, Caroline Laura Relton, Dianne Ford, John Cummings Mathers, Gordon Strathdee, Jill Ann McKay
Scope; Inadequate maternal folate intake is associated with increased childhood acute lymphoblastic leukaemia (ALL) risk. Folate provides methyl groups for DNA methylation, which is dramatically disrupted in ALL. We investigated if maternal folate (and related B-vitamin) intake during pregnancy may affect ALL risk via influencing DNA methylation. Methods and Results; We identified genes in which methylation changes were reported both in response to folate status and in ALL. Folate-responsive genes (n = 526) were identified from mouse models of maternal folate depletion during pregnancy...
September 7, 2018: Molecular Nutrition & Food Research
Paula Mapelli-Brahm, Charles Desmarchelier, Marielle Margier, Emmanuelle Reboul, Antonio J Meléndez Martínez, Patrick Borel
SCOPE: Absorption mechanisms of (PT) and phytofluene (PTF) are poorly known. Our main objectives were to measure their micellization and intestinal cell uptake efficiencies, and to compare them to that of commonly consumed carotenoids. Other objectives were to assess the involvement of protein(s) in their cellular uptake and whether they compete with other carotenoids for micellization and cellular uptake. METHODS AND RESULTS: Tomato extract purified PT and PTF, mainly present as cis-isomers, were much better incorporated in synthetic mixed micelles than pure all-trans lycopene...
September 7, 2018: Molecular Nutrition & Food Research
Miho Chikazawa, Ryuichiro Sato
SCOPE: Modulating β2 -adrenergic receptor (β2 -AR) expression and activation is important for maintaining skeletal muscle function. In this study, we identified two food factors, resveratrol (RSV) and genistein (GEN), that are able to regulate β2 -AR promoter activity and may improve skeletal muscle function. METHODS AND RESULTS: Using luciferase reporter assay, we screened 357 functional food factors as candidates for β2 -AR promoter activity and subsequently confirmed that RSV and GEN increase β2 -AR promoter activity and β2 -AR mRNA expression...
September 5, 2018: Molecular Nutrition & Food Research
Yun Ji, Zhaolai Dai, Shiqiang Sun, Xiaoshi Ma, Ying Yang, Patrick Tso, Guoyao Wu, Zhenlong Wu
SCOPE: Inflammatory bowel disease (IBD) is a chronic disease of gastrointestinal tract in which oxidative stress and overactivation of inflammatory response are implicated. The aim of the present study was to test the hypothesis that hydroxyproline (Hyp), an amino acid with an antioxidative property, attenuates DSS-induced colitis in mice. METHODS AND RESULTS: Male C57BL/6 supplemented with or without 1% Hyp were subjected to 2.5% DSS to induce colitis. Hyp attenuated the severity of colitis as evidenced by reduced disease activity index scores, decreased myeloperoxidase activity, histological damage, and apoptosis...
September 5, 2018: Molecular Nutrition & Food Research
Yongeun Kim, Sathish Kumar Natarajan, Soonkyu Chung
SCOPE: Gamma-tocotrienol (γT3), an unsaturated isoform of vitamin E, is implicated in the hepatoprotective effects. The aim is to determine the effectiveness of γT3 on nonalcoholic fatty liver disease (NAFLD). METHODS AND RESULTS: C57BL/6 male mice are fed a diet containing high fat (45%) and cholesterol (0.2%) along with sucrose drink (HFCS) or HFCS diet supplemented with 0.1% γT3 (HFCS + γT3). The inclusion of γT3 robustly decreases the HFCS diet-induced de novo lipogenesis (DNL), ER stress, and inflammation leading to reduced hepatic steatosis and fibrosis...
September 5, 2018: Molecular Nutrition & Food Research
Marynka M Ulaszewska, Christoph H Weinert, Alessia Trimigno, Reto Portmann, Cristina Andres Lacueva, René Badertscher, Lorraine Brennan, Carl Brunius, Achim Bub, Francesco Capozzi, Marta Cialiè Rosso, Chiara E Cordero, Hannelore Daniel, Stephanie Durand, Bjoern Egert, Paola G Ferrario, Edith J M Feskens, Pietro Franceschi, Mar Garcia-Aloy, Franck Giacomoni, Pieter Giesbertz, Raúl González-Domínguez, Kati Hanhineva, Lieselot Y Hemeryck, Joachim Kopka, Sabine Kulling, Rafael Llorach, Claudine Manach, Fulvio Mattivi, Carole Migné, Linda H Münger, Beate Ott, Gianfranco Picone, Grégory Pimentel, Estelle Pujos-Guillot, Samantha Riccadonna, Manuela Rist, Caroline Rombouts, Josep Rubert, Thomas Skurk, Pedapati S C Sri Harsha, Lieven Van Meulebroek, Lynn Vanhaecke, Rosa Vázquez-Fresno, David Wishard, Guy Vergères
The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by metabolism in nutrition, metabolomics is rapidly being established as a key analytical tool in human nutritional studies. Consequently, an increasing number of nutritionists integrate metabolomics into their study designs. Within this dynamic landscape, the potential of nutritional metabolomics (nutrimetabolomics) to be translated into a science, which can impact on health policies, still needs to be realized...
September 3, 2018: Molecular Nutrition & Food Research
Yi-Shiou Chiou, Shiming Li, Chi-Tang Ho, Min-Hsiung Pan
Starting from the 21st century, breast cancer can be classified as the most common invasive malignancy in women. Among the preventive or therapeutic strategies of breast cancer, combination therapy is the most promising approach. This mode of treatment of breast cancer concurrently maximizes efficacy, overcomes multi-drug resistance and minimizes harmful side effects caused by radiotherapy and chemotherapy alone. The risk of cancer can be reduced by supplementing diets with naturally occurring products, known as phytochemicals...
August 31, 2018: Molecular Nutrition & Food Research
Shigeru Katayama, Daiki Yamaguchi, Yuta Suzuki, Ahmad M Al Athamneh, Takakazu Mitani, Rie Satoh, Reiko Teshima, Yoshinori Mine, Soichiro Nakamura
SCOPE: Buckwheat is a common food allergen frequently consumed in Asian countries, with Fag e 1 and Fag e 2 being the major buckwheat allergens. The purpose of this study is to prepare an oral immunotherapy agent by attenuating these allergens via phosphorylation. The immunomodulatory effects of phosphorylated Fag e 2 (P-Fag e 2) in a mouse model of buckwheat allergy are evaluated. METHODS AND RESULTS: Phosphorylated Fag e 1 (P-Fag e 1) and P-Fag e 2 are prepared by dry-heating in the presence of pyrophosphate...
August 30, 2018: Molecular Nutrition & Food Research
Mengfan Yue, Ni Zeng, Yufeng Xia, Zhifeng Wei, Yue Dai
SCOPE: Morin, a flavonoid occurring in many dietary plants, can reduce the number of synovial blood vessels and ameliorate collagen-induced arthritis (CIA) in rats. Herein, its underlying mechanisms in view of the peroxisome proliferator activated receptor-γ (PPARγ) pathway are addressed. METHODS AND RESULTS: In vitro, wound-healing and transwell assays are conducted to explore the effect of morin on HUVECs migration. Morin inhibits HUVECs migration and tube formation induced by VEGF, which is reversed by PPARγ antagonist GW9662 or siPPARγ...
August 30, 2018: Molecular Nutrition & Food Research
Yinghua Yu, Craig Patch, Katrina Weston-Green, Yuan Zhou, Kuiyang Zheng, Xu-Feng Huang
SCOPE: A high-fat, but low-fiber, diet is associated with obesity and cognitive dysfunction, while dietary fiber supplementation can improve cognition. METHODS AND RESULTS: This study examines whether dietary fibers, galacto-oligosaccharides (GOS) and resistant starch (RS), could prevent high-fat (HF)-diet-induced alterations in neurotransmitter receptor densities in brain regions associated with cognition and appetite. Rats are fed a HF diet, HF diet with GOS, HF diet with RS, or a low-fat (LF, control) diet for 4 weeks...
August 27, 2018: Molecular Nutrition & Food Research
Hae-Ji Lee, Yun-Ha Hwang, Dong-Hyun Kim
SCOPE: This study was aimed to determine whether Lactobacillus plantarum C29-fermented defatted soybean (FDS, DW2009) could attenuate memory impairment in 5XFAD transgenic (Tg) mice. METHODS AND RESULTS: Oral administration of FDS or C29 increased cognitive function in Tg mice in passive avoidance, Y-maze, novel object recognition, and Morris water maze tasks. FDS or C29 treatment significantly suppressed amyloid-β, β/γ-secretases, caspase-3 expression, NF-κB activation, and activated microglia and apoptotic neuron cell populations and increased BDNF expression in the brain...
August 27, 2018: Molecular Nutrition & Food Research
Kazuya Fukuyama, Shota Kakio, Yosuke Nakazawa, Kenji Kobata, Megumi Funakoshi-Tago, Toshiharu Suzuki, Hiroomi Tamura
SCOPE: Epidemiological studies have shown that coffee consumption may be associated with a lower risk of developing several neurological disorders, including Alzheimer's disease (AD). Caffeine is a prominent candidate component underlying the preventive effects of coffee; however, the contribution of other constituents is unclear. To clarify this issue, the effect of roasting coffee beans on β-secretase (BACE1) expression in human neuroblastoma SH-SY5Y cells is investigated. METHODS AND RESULTS: Coffee (2%) reduces Aβ accumulation in culture medium to 80% of control levels after 24 h...
August 25, 2018: Molecular Nutrition & Food Research
Martine Naranjo Pinta, Ivan Montoliu, Anna-Marja Aura, Tuulikki Seppänen-Laakso, Denis Barron, Sofia Moco
SCOPE: Quinic acid in its free form is broadly abundant in plants, and can accumulate in copious amounts in coffee, tea, and certain fruits. However, it has been mostly studied as chlorogenic acid, an ester of caffeic and quinic acids. When chlorogenic acid reaches the colon, it is hydrolyzed by microbial esterases releasing caffeic and quinic acids. While biotransformation of chlorogenic and caffeic acids have been elucidated by in vitro and in vivo studies, the gut metabolism of quinic acid has been so far overlooked...
August 16, 2018: Molecular Nutrition & Food Research
Marc Pignitter, Michael Lindenmeier, Gaby Andersen, Cornelia Herrfurth, Christopher Beermann, Joachim J Schmitt, Ivo Feussner, Martin Fulda, Veronika Somoza
SCOPE: We aimed at identifying (1) the most sensitive compartment among plasma phospholipids, erythrocytes and LDL for studying ALA conversion, and (2) whether ALA incorporation and conversion is saturable after administration of 13 C-labeled ALA-rich linseed oil (LO). The effect of a daily intake of 7g non-labeled LO (>43% w/w ALA) for one month after bolus administration of 7g 13 C-labeled LO on day one, and for two months after bolus administration of 7g 13 C-labeled LO on day one and day 29 on 13 C-ALA incorporation and conversion into its higher homologs was investigated in healthy volunteers...
August 13, 2018: Molecular Nutrition & Food Research
Camila Oliveira de Souza, Carina A Valenzuela, Ella J Baker, Elizabeth A Miles, José C Rosa Neto, Philip C Calder
SCOPE: Fatty acids (FAs) may affect endothelial cell (EC) function, influencing atherogenesis and inflammatory processes. Palmitoleic acid (POA) has been described as an anti-inflammatory FA. However, its effects on ECs are underexplored. This study compares the effects of POA with those of palmitic acid (PA) and oleic acid (OA) on EC inflammatory responses. METHODS AND RESULTS: EAHy926 cells (EC lineage) are exposed to PA, OA, or POA, and stimulated with tumor necrosis factor (TNF)-α...
August 13, 2018: Molecular Nutrition & Food Research
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