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Molecular Nutrition & Food Research

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https://www.readbyqxmd.com/read/28218451/specific-inulin-type-fructan-fibers-protect-against-autoimmune-diabetes-by-modulating-gut-immunity-barrier-function-and-microbiota-homeostasis
#1
Kang Chen, Hao Chen, Marijke M Faas, Bart J de Haan, Jiahong Li, Ping Xiao, Hao Zhang, Julien Diana, Paul de Vos, Jia Sun
SCOPE: Dietary fibers capable of modifying gut barrier and microbiota homeostasis, affect the progression of type 1 diabetes (T1D). Here we aim to compare modulatory effects of inulin-type fructans (ITFs), natural soluble dietary fibers with different degrees of fermentability from chicory root, on T1D development in non-obese diabetic (NOD) mice. METHODS AND RESULTS: Female NOD mice were weaned to long and short chain ITFs [ITF(l) and ITF(s), 5%] supplemented diet up to 24 weeks...
February 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28218448/chronic-supplementation-with-dietary-proanthocyanidins-protects-from-diet-induced-intestinal-alterations-in-obese-rats
#2
Gil-Cardoso Katherine, Ginés Iris, Pinent Montserrat, Ardévol Anna, Arola Lluís, Blay Mayte, Terra Ximena
SCOPE: Increased attention has been paid to the link between altered intestinal function and elevated incidence of metabolic disorders, such as in obesity. The present study investigated in obese rats the role of grape seed proanthocyanidin extract (GSPE) chronic treatment, taken in a low, moderate or high dose, on obesity-associated intestinal alterations in response to a cafeteria diet (CAF). METHODS AND RESULTS: To evaluate the degree of intestinal inflammation, ROS production and MPO activity were measured as well as the expression of inflammatory related genes...
February 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28218440/physiologically-based-kinetic-modeling-of-hesperidin-metabolism-and-its-use-to-predict-in-vivo-effective-doses-in-humans
#3
Rungnapa Boonpawa, Albertus Spenkelink, Ans Punt, Ivonne M C M Rietjens
SCOPE: To develop a physiologically based kinetic (PBK) model that describes the absorption, distribution, metabolism, and excretion (ADME) of hesperidin in humans, enabling the translation of in vitro concentration-response curves to in vivo dose-response curves. METHODS AND RESULTS: The PBK model for hesperidin in humans was developed based on in vitro metabolic parameters. Hesperidin was predicted to mainly occur in the systemic circulation as different monoglucuronides...
February 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28218439/the-effects-of-exogenous-fatty-acids-and-niacin-on-human-monocyte-macrophage-plasticity
#4
Sergio Montserrat-de la Paz, Dolores Rodriguez, Magdalena P Cardelo, Maria C Naranjo, Beatriz Bermudez, Rocio Abia, Francisco J G Muriana, Sergio Lopez
SCOPE: Macrophage plasticity allows adapting to different environments, having a dual activity in inflammatory-related diseases. Our hypothesis is that the type of dietary fatty acids into human postprandial triglyceride-rich lipoproteins (TRLs), alone or in combination with niacin (vitamin B3), could modulate the plasticity of monocytes-macrophages. METHODS AND RESULTS: We isolated TRLs at the postprandial peak from blood samples of healthy volunteers after the ingestion of a meal rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) or MUFAs plus omega-3 long-chain polyunsaturated fatty acids (LCPUFAs)...
February 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28211258/effects-of-a-wide-range-of-dietary-nicotinamide-riboside-nr-concentrations-on-metabolic-flexibility-and-white-adipose-tissue-wat-of-mice-fed-a-mildly-obesogenic-diet
#5
Wenbiao Shi, Maria A Hegeman, Dorien A M van Dartel, Jing Tang, Manuel Suarez, Hans Swarts, Bart van der Hee, Lluis Arola, Jaap Keijer
SCOPE: Metabolic flexibility is the ability to switch metabolism between carbohydrate oxidation (CHO) and fatty acid oxidation (FAO) and is a biomarker for metabolic health. The effect on metabolic health of nicotinamide riboside (NR) as an exclusive source of vitamin B3 is unknown and is examined here for a wide range of NR. DESIGN AND METHODS: Nine-week-old male C57BL/6JRcc mice received a semi-purified mildly obesogenic (40 en% fat) diet containing 0.14% L-tryptophan and either 5, 15, 30, 180 or 900 mg NR per kg diet for 15 weeks...
February 16, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28205387/fructose-down-regulates-mir-330-to-induce-renal-inflammatory-response-and-insulin-signaling-impairment-attenuation-by-morin
#6
Ting-Ting Gu, Lin Song, Tian-Yu Chen, Xin Wang, Xiao-Juan Zhao, Xiao-Qin Ding, Yan-Zi Yang, Ying Pan, Dong-Mei Zhang, Ling-Dong Kong
SCOPE: Fructose induces insulin resistance with kidney inflammation and injury. MicroRNAs (miRNAs) are emerged as key regulators of insulin signaling. Morin has insulin-mimetic effect with the improvement of insulin resistance and kidney injury. This study investigated the protective mechanisms of morin against fructose-induced kidney injury, with particular focus on miR-330 expression change, inflammatory response and insulin signaling impairment. METHODS AND RESULTS: miR-330, sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P)/S1P receptor (S1PR)1/3 signaling, NF-κB/NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome and insulin signaling were detected in kidney cortex of fructose-fed rats and fructose-exposed HK-2 cells, respectively...
February 16, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28205325/wholegrain-oat-diet-changes-the-expression-of-genes-associated-with-intestinal-bile-acid-transport
#7
Kristina E Andersson, Aakash Chawade, Narda Thuresson, Ana Rascon, Rickard Öste, Olov Sterner, Olof Olsson, Per Hellstrand
SCOPE: The molecular mechanisms underlying the cholesterol-lowering properties of oats are only partly known. To study possible pathways involved, we investigated gene expressions in the liver and small intestine of mice fed oats. METHOD AND RESULTS: Cholesterol and bile acids were analysed in plasma and faeces from LDL-receptor deficient (LDLr(-/-) ) mice fed Western diet with wholegrain oats. A transcriptome analysis of mRNA from liver and jejunum was performed together with quantitative RT-PCR...
February 16, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28198144/the-phenolic-fraction-of-extra-virgin-olive-oil-modulates-the-activation-and-the-inflammatory-response-of-t-cells-from-patients-with-systemic-lupus-erythematosus-and-healthy-donors
#8
Marina Aparicio-Soto, Marina Sanchez-Hidalgo, Ana Cárdeno Galván, Jose Manuel Lucena, Francisca Gonzalez-Escribano, Maria Jesus Castillo Palma, Catalina Alarcón-de-la-Lastra
SCOPE: Systemic lupus erythematosus (SLE) is a chronic multiorgan autoimmune disease characterized by immune deregulation, which involves altered T-cell response and imbalance of cytokine production. The phenolic fraction (PE) of extra virgin olive oil (EVOO) possesses anti-inflammatory and immunomodulatory properties and exerts preventive effects in murine models of immune-inflammatory diseases, such as SLE. The present study was designed to determine the in vitro effects of the PE from EVOO on peripheral blood mononuclear cells (PBMC) from inactive patients with SLE and healthy donors...
February 15, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28191711/bioinformatic-screening-and-detection-of-allergen-cross-reactive-ige-binding-epitopes
#9
Scott McClain
Protein allergens can be related by cross-reactivity. Allergens that share relevant sequence can cross-react, those lacking similarity in their IgE antibody-binding epitopes do not cross-react. Cross-reactivity is based on shared epitopes which is due to shared sequence and higher level structure (charge and shape). Epitopes can be important in predicting cross-reactivity potential and may provide the potential to establish criteria that identify homology among allergens. Selected allergen's IgE binding epitope sequences were used to determine how the FASTA algorithm could be used to identify a threshold of significance...
February 13, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28181408/epigallocatechin-gallate-induces-an-up-regulation-of-ldl-receptor-accompanied-by-a-reduction-of-pcsk9-via-the-annexin-a2-independent-pathway-in-hepg2-cells
#10
Kohei Kitamura, Yudai Okada, Kenji Okada, Yuya Kawaguchi, Satoshi Nagaoka
SCOPE: In animal studies, epigallocatechin gallate (EGCG), the dominant catechin in green tea, has been shown to improve cholesterol metabolism. However, the molecular mechanisms of EGCG underlying these functions have not been fully understood. In this study, we aimed to clarify the molecular mechanisms of the effect of EGCG on cholesterol metabolism mainly in HepG2 cells. METHODS AND RESULTS: We found that EGCG induced a reduction of the extracellular proprotein convertase subtilisin/kexin 9 (PCSK9) level accompanied by an up-regulation of the LDL receptor (LDLR) in HepG2 cells...
February 9, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28181403/caffeic-acid-phenethyl-ester-upregulates-n-myc-downstream-regulated-gene-1-via-erk-pathway-to-inhibit-human-oral-cancer-cell-growth-in-vitro-and-in-vivo
#11
Li-Chuan Chung, Kun-Chun Chiang, Tsui-Hsia Feng, Kang-Shuo Chang, Sung-Ting Chuang, Yu-Jen Chen, Ke-Hung Tsui, Jehn-Chuan Lee, Horng-Heng Juang
SCOPE: Caffeic acid phenethyl ester (CAPE), a bioactive component of propolis, is considered as a new anti-cancer agent. Oral squamous cell carcinoma (OSCC) is the most common oral cancer with unsatisfying survival. N-myc downstream regulated family genes (NDRGs) involve in numerous physiological processes. We investigated the anti-cancer effect of CAPE on OSCC and related mechanisms. METHODS AND RESULTS: Cell proliferation assay, western blot, gene transfection and knockdown, and reporter assay were applied...
February 9, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28160405/distribution-of-trans-resveratrol-and-its-metabolites-after-acute-or-sustained-administration-in-mouse-heart-brain-and-liver
#12
Marie-Claude Menet, Stephanie Baron, Meryam Taghi, Remi Diestra, Delphine Dargère, Olivier Laprévote, Valérie Nivet-Antoine, Jean-Louis Beaudeux, Tatiana Bédarida, Charles-Henry Cottart
SCOPE: Trans-resveratrol is widely studied for its potentially beneficial effects on numerous disorders. It is rapidly metabolized and its metabolites can exhibit biological activity. The present study aimed to investigate whether acute or sustained trans-resveratrol administration impacted on the distribution of trans-resveratrol and its metabolites in brain, heart, and liver. METHODS AND RESULTS: We used UHPLC-Q-TOF in full-scan mode to identify and assess large numbers of resveratrol metabolites...
February 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28155259/complementary-cereals-and-legumes-for-health-synergistic-interaction-of-sorghum-flavones-and-cowpea-flavonols-against-lps-induced-inflammation-in-colonic-myofibroblasts
#13
Shima Agah, Hyemee Kim, Susanne Talcott, Joseph M Awika
SCOPE: Cereals and legumes are traditionally consumed together in many cultures, and may provide complementary health benefits beyond what is known about improved indispensable amino acid intake. Here we use an in vitro model of inflammatory pathways to investigate whether the different flavonoids in sorghum and cowpea could synergistically reduce inflammation. METHODS AND RESULTS: Interactive effect of combining apigenin and quercetin, as well as extracts (70% acetone, v/v) from a flavone-dominated white sorghum and flavonol-dominated white cowpea, against LPS-induced NF-κB and downstream cytokines (TNF-α, IL-6, IL-8) gene and protein expression was evaluated using the CCD18co colon myofibroblasts...
February 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28155258/phytochemicals-in-whole-grain-wheat-and-their-health-promoting-effects
#14
Yingdong Zhu, Shengmin Sang
Accumulated evidence in epidemiological studies has consistently shown that consumption of whole grains is inversely associated with risk of major chronic diseases such as certain types of cancer, type 2 diabetes, and cardiovascular diseases. Dietary fiber has been reported to be responsible for the health effects of whole grain consumption. Evidence from in vitro and in vivo studies is emerging that, in addition to dietary fiber and minerals, the unique phytochemicals in whole grains may in part contribute to these health-promoting effects...
February 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28133948/maternal-high-salt-diet-altered-adenosine-mediated-vasodilatation-via-pka-bkchannel-pathway-in-offspring-rats
#15
Jue Wu, Na Li, Yanping Liu, Weisheng Li, Axin He, Di Zhu, Xueqin Feng, Bailin Liu, Ruixiu Shi, Yujuan Zhang, Juanxiu Lv, Zhice Xu
SCOPE: High salt (HS) diets are related to cardiovascular diseases, and prenatal HS was suggested to increase risks of coronary artery diseases in the offspring. This study tested the hypothesis that prenatal HS may influence Adenosine-induced vasodilatation via PKA pathway in coronary arteries. METHODS AND RESULTS: Sprague-Dawley rats were fed with 8% salt diet for gestation, the control was fed with 0.3% salt diet. Coronary arteries from male adult offspring were tested for K(+) channels and Adenosine signal pathways...
January 29, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28133928/n-%C3%AE-l-glutamyl-l-selenomethionine-enhances-stress-resistance-and-ameliorates-aging-indicators-via-the-selenoprotein-trxr-1-in-caenorhabditis-elegans
#16
Chun-Han Chang, Chi-Tang Ho, Vivian Hsiu-Chuan Liao
SCOPE: Selenium is an essential trace nutrient for human health. This study investigates the organic form of selenium, N-γ-(L-Glutamyl)-L-selenomethionine (Glu-SeMet), for its effects on aging indicators and stress resistance. The role of the selenoprotein TRXR-1 was also evaluated in Caenorhabditis elegans. METHODS AND RESULTS: Glu-SeMet-treated wild-type N2 worms showed increased survival upon oxidative and thermal stress challenges. However, Glu-SeMet treatment did not extend the lifespan of wild-type N2 C...
January 29, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28133904/lifelong-intake-of-flaxseed-or-menhaden-oil-to-provide-varying-n-6-to-n-3-pufa-ratios-modulate-bone-microarchitecture-during-growth-but-not-after-ovx-in-sprague-dawley-rats
#17
Amanda B Longo, Phillip J Sullivan, Sandra J Peters, Paul J LeBlanc, Gregory R Wohl, Wendy E Ward
SCOPE: Skeletal health is a lifelong process impacted by environmental factors, including nutrient intake. The n-3 source and PUFA ratio affect bone health in growing rats, or following ovariectomy (OVX), but no study has investigated the longitudinal effect of PUFA-supplementation throughout these periods of bone development. METHODS AND RESULTS: One month old, Sprague-Dawley rats (n = 98) were randomized to receive 1 of 4 diets from 1 through 6 months of age. Diets were modified from AIN-93G to contain a varying amount and source of n-3 (flaxseed versus menhaden oil) to provide an n-6 to n-3 ratio of 10:1 or 5:1...
January 29, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28130879/variations-in-dietary-intake-and-plasma-concentration-of-plant-sterols-across-plant-based-diets-among-north-american-adults
#18
Karen Jaceldo-Siegl, Dieter Lütjohann, Rawiwan Sirirat, Andrew Mashchak, Gary E Fraser, Ella Haddad
SCOPE: Phytosterols are bioactive compounds in plants with similar cholesterol-lowering properties as vegetarian diets. However, information on phytosterol intake and plasma plant sterols among vegetarians is sparse. METHODS AND RESULTS: We examined dietary intake and plasma concentration of plant sterols and cholesterol across five dietary patterns in the Adventist Health Study-2 Calibration Sub-study (n = 861, 66% females, average age 61 y). To measure intake and plasma concentration of these compounds, we used 24-hour dietary recalls and gas-liquid chromatography-flame ionization detection, respectively...
January 28, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28130829/inflammatory-potential-of-the-diet-and-mortality-in-the-spanish-cohort-of-the-european-prospective-investigation-into-cancer-and-nutrition-epic-spain
#19
Antonio Agudo, Raquel Masegú, Catalina Bonet, Paula Jakszyn, J Ramon Quirós, Eva Ardanaz, Conchi Moreno-Iribas, Aurelio Barricarte, Pilar Amiano, Larraitz Arriola, Saioa Chamosa, Miren Dorronsoro, Nerea Larrañaga, Carmen Navarro, María-Dolores Chirlaque, Lluís Cirera, Diana Gavrila, José-María Huertas, Miguel Rodriguez-Barranco, Elena Molina-Portillo, Maria-José Sánchez
SCOPE: Low-grade chronic inflammation is associated with several chronic conditions, and diet is known to play a role in chronic inflammation. We aimed to evaluate the association between the inflammatory potential of the diet and mortality in the Spanish population from the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). METHODS AND RESULTS: The study included 41199 participants (62% female) aged 29-69 years from 5 Spanish regions. During 18 years of follow-up 3316 deaths were identified...
January 28, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28130827/advanced-glycation-end-products-stimulate-gene-expression-of-fibroblast-growth-factor-23
#20
Ludmilla Bär, Kristin Wächter, Nicole Wege, Alexander Navarrete Santos, Andreas Simm, Michael Föller
SCOPE: Osteoblasts produce fibroblast growth factor 23 (FGF23), a hormone inhibiting renal phosphate reabsorption and the formation of biologically active vitamin D, calcitriol. FGF23-deficient mice age rapidly and develop age-associated diseases at least in part due to massive calcification. Elevated FGF23 serum levels are detected in patients suffering from acute and chronic renal, cardiovascular, inflammatory, and metabolic diseases. Advanced glycation end products (AGEs) are sugar-modified proteins, nucleic acid, and lipids which contribute to these disorders...
January 28, 2017: Molecular Nutrition & Food Research
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