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Molecular Nutrition & Food Research

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https://www.readbyqxmd.com/read/28734036/-epicatechin-regulates-blood-lipids-and-attenuates-hepatic-steatosis-in-rats-fed-high-fat-diet-%C3%A2
#1
Hui Cheng, Na Xu, Wenxia Zhao, Jingjing Su, Mengru Liang, Zhongwen Xie, Xianli Wu, Qinglin Li
SCOPE: (-)-Epicatechin (EC) is a natural flavanol monomer found in cocoa, green tea and a variety of other plant foods. In this study, effects of EC on blood lipids and hepatic steatosis, and the underlying mechanisms were investigated. METHODS AND RESULTS: A hyperlipidemic rat model was induced by high-fat, high-cholesterol diet. EC was then administrated to the animals by gavage at doses of 10 mg/kg, 20 mg/kg, 40 mg/kg body weight (BW) for 12 weeks. Simvastatin was included as a positive control...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28734033/genistein-and-enterolactone-in-relation-to-ki-67-expression-and-her2-status-in-postmenopausal-breast-cancer-patients
#2
Stefanie Jaskulski, Audrey Y Jung, Anja Rudolph, Theron Johnson, Kathrin Thöne, Esther Herpel, Peter Sinn, Jenny Chang-Claude
SCOPE: Phytoestrogens (PE) may improve breast cancer prognosis by modifying tumor prognostic markers, such as cell proliferation marker Ki-67 and human epidermal growth factor receptor 2 (HER2). Epidemiological evidence linking lignans and isoflavones to Ki-67 and HER2 is limited. We examined associations between the major metabolites of lignans and isoflavones - enterolactone (ENL) and genistein (GEN) - respectively, and Ki-67 expression and HER2 in tumor tissue of breast cancer patients...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28731263/commercial-strain-derived-clinical-saccharomyces-cerevisiae-can-evolve-new-phenotypes-without-higher-pathogenicity
#3
Walter P Pfliegler, Enikő Boros, Kitti Pázmándi, Ágnes Jakab, Imre Zsuga, Renátó Kovács, Edit Urbán, Zsuzsa Antunovics, Attila Bácsi, Matthias Sipiczki, László Majoros, István Pócsi
SCOPE: Saccharomyces cerevisiae is one of the most important microbes in food industry, but there is growing evidence on its potential pathogenicity as well. Its status as a member of human mycobiome is still not fully understood. METHODS AND RESULTS: In this study, we characterise clinical S. cerevisiae isolates from Hungarian hospitals along with commercial baking and probiotic strains, and determine their phenotypic parameters, virulence factors, interactions with human macrophages, and pathogenicity...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28731213/immunomodulatory-properties-of-olea-europaea-leaf-extract-in-intestinal-inflammation
#4
Teresa Vezza, Francesca Algieri, Alba Rodríguez-Nogales, José Garrido-Mesa, M Pilar Utrilla, Nassima Talhaoui, Ana María Gómez-Caravaca, Antonio Segura-Carretero, M Elena Rodríguez-Cabezas, Giovanni Monteleone, Julio Gálvez
SCOPE: Extracts from olive (Olea europaea) leaves are used in Mediterranean traditional medicine as anti-inflammatory. They contain antioxidant phenolic compounds, like oleuropeoside, which could be interesting for the treatment of inflammatory conditions associated with oxidative stress in humans, including inflammatory bowel disease. METHODS AND RESULTS: The anti-inflammatory effects of olive leaf extract (0.5-25 mg/kg) were studied in two mice models of colitis (DSS and DNBS)...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28730743/inulin-type-fructans-and-whey-protein-both-modulate-appetite-but-only-fructans-alter-gut-microbiota-in-adults-with-overweight-obesity-a-randomized-controlled-trial
#5
Raylene A Reimer, Holly J Willis, Jasmine M Tunnicliffe, Heekuk Park, Karen L Madsen, Adriana Soto-Vaca
SCOPE: Independently, prebiotics and dietary protein have been shown to improve weight loss and/or alter appetite. Our objective was to determine the effect of combined prebiotic and whey protein on appetite, body composition and gut microbiota in adults with overweight/obesity. METHODS AND RESULTS: In a 12 week, placebo-controlled, double-blind study, 125 adults with overweight/obesity were randomly assigned to receive isocaloric snack bars of: 1) Control; 2) Inulin-type fructans (ITF); 3) Whey protein; 4) ITF + Whey protein...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28730708/evaluation-of-the-hypocholesterolemic-effect-and-prebiotic-activity-of-a-lentil-lens-culinaris-medik-extract
#6
Maria Vittoria Micioni Di Bonaventura, Cinzia Cecchini, Pilar Vila Donat, Giovanni Caprioli, Carlo Cifani, Maria Magdalena Coman, Alberto Cresci, Dennis Fiorini, Massimo Ricciutelli, Stefania Silvi, Sauro Vittori, Gianni Sagratini
SCOPE: the aim of our work was to produce a hydroalcoholic extract of lentils and to examine: a) the hypocholesterolemic action in an animal model, by studying the plasma cholesterol level and the concentration of bile acids in the faeces; b) the potential prebiotic effect, by conducting an in vitro culture fermentation experiment and assessing the level of short chain fatty acids (SCFAs) in the faeces of rats. METHODS AND RESULTS: Lentil extract (LE) was obtained by extracting lentils with a solution of H2 0/EtOH (70/30 v/v) for 3 h, and the content of main nutrients was determined...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28730734/efficacy-and-safety-of-sugarcane-policosanol-on-dyslipidemia-a-meta-analysis-of-randomized-controlled-trials
#7
Jing Gong, Xin Qin, Fen Yuan, Meilin Hu, Guang Chen, Ke Fang, Dingkun Wang, Shujun Jiang, Jingbin Li, Yan Zhao, Zhaoyi Huang, Hui Dong, Fuer Lu
SCOPE: This study aimed to systematically investigate whether sugarcane policosanol was effective and safe on dyslipidemia. METHODS AND RESULTS: A total of 11 databases including the PubMed, Web of science, Embase, Scopus, the Cochrane library and SinoMed databases were searched for available studies investigating the effects of policosanol on dyslipidemia. A total of 22 studies including 1886 subjects were included in the analysis. The pooled results showed that compared with placebo, sugarcane policosanol could significantly reduce total cholesterol (TC, 95% CI: -0...
July 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28726320/assessing-neurodevelopmental-effects-of-arsenolipids-in-pre-differentiated-human-neurons
#8
Barbara Witt, Franziska Ebert, Sören Meyer, Kevin A Francesconi, Tanja Schwerdtle
SCOPE: In the general population exposure to arsenic occurs mainly via diet. Highest arsenic concentrations are found in seafood, where arsenic is present predominantly in its organic forms including arsenolipids. Since recent studies have provided evidence that arsenolipids could reach the brain of an organism and exert toxicity in fully differentiated human neurons, this work aims to assess the neurodevelopmental toxicity of arsenolipids. METHODS AND RESULTS: Neurodevelopmental effects of three arsenic-containing hydrocarbons (AsHC), two arsenic-containing fatty acids (AsFA), arsenite and dimethylarsinic acid (DMA(V) ) were characterized in pre-differentiated human neurons...
July 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28726277/aged-garlic-extract-suppresses-inflammation-in-apolipoprotein-e-knockout-mice
#9
Naoaki Morihara, Atsuko Hino, Satomi Miki, Miyuki Takashima, Jun-Ichiro Suzuki
SCOPE: Chronic inflammation plays a major role in the formation and progression of atherosclerotic plaques. To clarify the mode of action of aged garlic extract (AGE) to retard atherosclerosis, we investigated whether AGE suppresses the inflammation in apolipoprotein E-knockout (ApoE-KO) mice. METHODS AND RESULTS: ApoE-KO mice were fed standard diet with or without 3% AGE for 12 weeks. AGE feeding inhibited the progression of atherosclerotic lesion by 27% and reduced the level of C-reactive protein (CRP) and thromboxane B2 (TXB2 ), a marker of platelet activation, in serum by 39% and 33%, respectively, compared to ApoE-KO mice without AGE treatment...
July 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28722302/a-novel-neurological-function-of-rice-bran-a-standardized-rice-bran-supplement-promotes-non-rapid-eye-movement-sleep-in-mice-through-histamine-h1-receptors
#10
Min Young Um, Sojin Kim, Young-Ho Jin, Minseok Yoon, Hyejin Yang, Jaekwang Lee, Jonghoon Jung, Yoshihiro Urade, Zhi-Li Huang, Sangoh Kwon, Suengmok Cho
SCOPE: Although rice bran has been shown to be associated with a wide spectrum of health benefits, to date, there are no reports on its effects on sleep. We investigated the effect of rice bran on sleep and the mechanism underlying this effect. METHODS AND RESULTS: Electroencephalography was used to evaluate the effects of standardized rice bran supplement (RBS) and doxepin hydrochloride (DH), a histamine H1 receptor (H1 R) antagonist used as a positive control, on sleep in mice...
July 19, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28722287/plasma-thiobarbituric-acid-reactive-substances-tbars-in-young-adults-obesity-increases-fasting-levels-only-in-men-whereas-glucose-ingestion-and-not-protein-or-lipid-intake-increases-postprandial-concentrations-regardless-of-sex-and-obesity
#11
Rafael Montes-Nieto, María Insenser, Mora Murri, Elena Fernández-Durán, Miriam Ojeda-Ojeda, M Ángeles Martínez-García, Manuel Luque-Ramírez, Héctor F Escobar-Morreale
SCOPE: Oxidative stress and damage participate in the pathophysiology of obesity and its metabolic complications. We studied the influence of sex, obesity and ingestion of different macronutrients on fasting and postprandial thiobarbituric acid reactive substances (TBARS), which can be considered as an index of lipid peroxidation and oxidative damage. METHODS AND RESULTS: We studied 19 men and 17 women, out of whom 9 men and 8 women had obesity. We collected blood samples in the fasting state and, on alternate days, following the ingestion of 300 kcal in the form of glucose, lipids or proteins...
July 19, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28722259/l-ornithine-and-l-lysine-stimulate-gastrointestinal-motility-via-transient-receptor-potential-vanilloid-1
#12
Junya Nakato, Yee Yin Ho, Ryo Omae, Takafumi Mizushige, Kunitoshi Uchida, Makoto Tominaga, Minji Kim, Tsuyoshi Goto, Nobuyuki Takahashi, Teruo Kawada, Saori Akiduki, Ryuhei Kanamoto, Kousaku Ohinata
SCOPE: The gastrointestinal (GI) tract senses and responds to intraluminal nutrients and these interactions often affect GI functions. We found that, among basic amino acids, L-ornithine (Orn) and L-lysine (Lys) stimulated but L-arginine (Arg) suppressed GI motility after oral administration (24 mmol/kg) in mice (Orn and Lys, 14.3 and 26.4% promotion; Arg, 7.7% suppression). We investigated the mechanism of the action of Orn and Lys on GI motility. METHODS AND RESULTS: Orn-induced promotion of small intestinal transit was significantly inhibited (P<0...
July 18, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28718977/effect-of-simulated-gastrointestinal-digestion-and-fermentation-on-polyphenolic-content-and-bioactivity-of-brown-seaweed-phlorotannin-rich-extracts
#13
Giulia Corona, Maria Magdalena Coman, Yuxuan Guo, Sarah Hotchkiss, Chris Gill, Parveen Yaqoob, Jeremy P E Spencer, Ian Rowland
SCOPE: Unlike other classes of polyphenols, there is a lack of knowledge regarding brown seaweed phlorotannins and their bioactivity. We investigated the impact of in vitro gastrointestinal digestion and colonic fermentation on the bioactivity of a seaweed phlorotannin extract from Ascophyllum nodosum and its high molecular weight (HMW) and low molecular weight (LMW) fractions. METHODS AND RESULTS: The highest phlorotannin and total polyphenol (TP) concentration was observed in the HMW fraction...
July 18, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28699236/piperonal-attenuates-visceral-adiposity-in-mice-fed-a-high-fat-diet-potential-involvement-of-the-adenylate-cyclase-protein-kinase-a-dependent-pathway
#14
Songyi Chu, Vikram P Narayan, Mi-Kyung Sung, Taesun Park
SCOPE: Piperonal is an aromatic compound found in vanilla and has a floral odor resembling vanillin. This study was aimed to test whether piperonal attenuates visceral adiposity induced by a high-fat diet (HFD) in mice and to explore the underlying molecular mechanisms. METHODS AND RESULTS: Male C57BL/6N mice were fed a normal diet, HFD, or 0.05% piperonal-supplemented HFD (PSD) for 10 weeks. PSD-fed mice showed attenuation of body weight gain, total visceral fat pad weights, and plasma lipid levels compared to HFD-fed mice...
July 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28691397/cyanidin-3-glucoside-increases-whole-body-energy-metabolism-by-upregulating-brown-adipose-tissue-mitochondrial-function
#15
Yilin You, Xiaoxue Yuan, Xiaomeng Liu, Chen Liang, Minghui Meng, Yuanyuan Huang, Xue Han, Jielong Guo, Yu Guo, Chenglong Ren, Qianwen Zhang, Xiangyu Sun, Tingting Ma, Guojie Liu, Wanzhu Jin, Weidong Huang, Jicheng Zhan
SCOPE: Obesity develops when energy intake exceeds energy expenditure. Promoting brown adipose tissue (BAT) formation and function increases energy expenditure and may protect against obesity. Cyanidin-3-glucoside (C3G) is an anthocyanin compound which occurs naturally in many fruits and vegetables. In this study, we investigated the effect and mechanism of C3G on the prevention of obesity. METHODS AND RESULTS: Db/db mice received C3G dissolved in drinking water for 16 weeks; Drinking water served as the vehicle treatment...
July 10, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28691370/bioaccessibility-bioavailability-and-anti-inflammatory-effects-of-anthocyanins-from-purple-root-vegetables-using-mono-and-co-culture-cell-models
#16
Hua Zhang, Hassan Yousef, Justin Renaud, Ronghua Liu, Cheng Yang, Yong Sun, Rong Tsao
SCOPE: Immune-inflammatory, signalling and metabolic effects are the main pillars for bioactivity of anthocyanins derived from highly pigmented root vegetables. This study aims to assess the bioaccessibility and bioavailability of purple carrot and potato derived anthocyanins and the molecular mechanisms of their ability to ameliorate cellular inflammation in a mono- and co-culture cell models. METHODS AND RESULTS: An in vitro gastrointestinal model was used and demonstrated bioaccessibility of 44...
July 10, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28691342/dual-function-of-lactobacillus-kefiri-dh5-in-preventing-high-fat-diet-induced-obesity-direct-reduction-of-cholesterol-and-upregulation-of-ppar%C3%AE-in-adipose-tissue
#17
Dong-Hyeon Kim, Dana Jeong, Il-Byeong Kang, Hyunsook Kim, Kwang-Young Song, Kun-Ho Seo
SCOPE: Kefir consumption inhibits the development of obesity and non-alcoholic fatty liver disease in mice fed 60% high-fat diet (HFD). To identify the key contributor of this effect, we isolated lactic acid bacteria (LAB) from kefir and examined their anti-obesity properties from in vitro screening and in vivo validation. METHODS AND RESULTS: Thirteen kefir LAB isolates were subjected to survivability test using artificial gastrointestinal environment and cholesterol-reducing assay...
July 10, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28688179/resveratrol-attenuates-excessive-ethanol-exposure-induced-insulin-resistance-in-rats-via-improving-nad-nadh-ratio
#18
Gang Luo, Bingqing Huang, Xiang Qiu, Lin Xiao, Ning Wang, Qin Gao, Wei Yang, Liping Hao
SCOPE: Resveratrol has been shown to improve insulin resistance via activating the NAD(+) -dependent deacetylase SIRT1, but the effects of resveratrol on ethanol-induced insulin resistance remain unclear. This study was designed to explore the potential mechanism by which resveratrol ameliorated ethanol-induced insulin resistance, focusing on its regulations on the ratio of NAD(+) /NADH and SIRT1 expression. METHODS AND RESULTS: Male Sprague-Dawley rats were fed either control or ethanol liquid diets containing 0...
July 8, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28688174/trans-lycopene-from-tomato-juice-attenuates-inflammatory-biomarkers-in-human-plasma-samples-an-intervention-trial
#19
Mariel Colmán-Martínez, Miriam Martínez-Huélamo, Palmira Valderas-Martínez, Sara Arranz-Martínez, Enrique Almanza-Aguilera, Dolores Corella, Ramón Estruch, Rosa M Lamuela-Raventós
SCOPE: To evaluate the effects of carotenoids from tomato juice (TJ) on inflammatory biomarkers, by performing a 4-week dose-response nutritional trial in a population at high cardiovascular risk. METHODS AND RESULTS: An open, prospective, randomized, cross-over, and controlledclinical trial was carried out with 28 volunteers (mean age 69.7 ± 3.1 years; mean BMI 31.5 ± 3.6 kg/m(2) ) at high cardiovascular risk, which were assigned to consume daily for 4 weeks in random order: 200 mL (LD) or 400 mL (HD) of TJ, or water as a control (C), with a 21-day wash-out period between each intervention...
July 8, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28688106/human-milk-exosomes-and-their-micrornas-survive-digestion-in-vitro-and-are-taken-up-by-human-intestinal-cells
#20
Yalin Liao, Xiaogu Du, Jie Li, Bo Lönnerdal
SCOPE: Human milk exosomes provide a natural means of genetic material transfer to infants; however, the effect of gastric/pancreatic digestion milk exosomes stability and their microRNA content is largely unknown. METHODS AND RESULTS: We took a simulated gastric/pancreatic digestion protocol to perform in vitro digestion of milk exosomes, explore intestinal epithelial uptake, and further elucidate microRNA responses to digestion at early-, mid-, -late lactation by massive parallel sequencing...
July 7, 2017: Molecular Nutrition & Food Research
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