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Molecular Nutrition & Food Research

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https://www.readbyqxmd.com/read/29774640/regulatory-roles-of-flavonoids-on-inflammasome-activation-during-inflammatory-responses
#1
REVIEW
Young-Su Yi
Inflammation is an innate immune response to noxious stimuli to protect the body from pathogens and dangers. Inflammatory responses consist of two main steps: priming and triggering. In priming, inflammatory cells increase expressions of inflammatory molecules, while in triggering, inflammasomes are activated, resulting in cell death and pro-inflammatory cytokine secretion. Inflammasomes are protein complexes comprising intracellular pattern recognition receptors (PRRs) (e.g. nucleotide-binding oligomerization domain-like receptors (NLRs), absent in melanoma 2 (AIM2), and caspases-4/5/11) and pro-caspase-1 with or without a bipartite adaptor molecule ASC...
May 17, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29763526/extra-virgin-olive-oil-with-natural-phenolic-content-exerts-an-anti-inflammatory-effect-in-adipose-tissue-and-attenuates-the-severity-of-atherosclerotic-lesions-in-ldlr-leiden-mice
#2
Amparo Luque-Sierra, Leticia Alvarez-Amor, Robert Kleemann, Franz Martín, Lourdes M Varela
SCOPE: We evaluated the effect of olive oils with different phenolic content in high-fat diets (HFDs) on hypertrophy and inflammation in adipose tissue and associated atherosclerosis, in the context of obesity. METHODS AND RESULTS: We used Ldlr-/-.Leiden mice fed three different HFDs for 32 weeks and compared them with mice fed the standard low-fat diet (LFD). The different fats provided in the HFDs were: lard (HFD-L), extra-virgin olive oil (79 mg kg-1 of phenolic compounds, HFD-EVOO), or extra-virgin olive oil rich in phenolic compounds (444mg kg-1 of phenolic compounds, HFD-OL)...
May 15, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29762899/metagenomics-analysis-of-gut-microbiota-in-a-high-fat-diet-induced-obesity-mouse-model-fed-with-epigallocatechin-3-o-3-o-methyl-gallate-egcg3-me
#3
Xin Zhang, Yuhui Chen, Jieyu Zhu, Man Zhang, Chi-Tang Ho, Qingrong Huang, Jinxuan Cao
SCOPE: (-)-Epigallocatechin 3-O-(3-O-methyl) gallate (EGCG3''Me) has been shown to have a modulatory effect on human intestinal microbiota, and the relationship between intestinal flora and obesity has attracted more and more attention recently. Here, we investigated the potential link between EGCG3''Me and gut microbiota composition, as well as the underlying mechanisms of the anti-obesity activity of EGCG3''Me. METHODS AND RESULTS: EGCG3''Me was prepared from oolong tea by column chromatography, and the influence of EGCG3''Me on intestinal microbiota was analysed using a human flora-associated high fat diet (HFD)-induced obesity mouse model by metagenomics...
May 15, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29757493/egg-yolk-provides-th2-adjuvant-stimuli-and-promotes-sensitization-to-egg-white-allergens-in-balb-c-mice
#4
Alba Pablos-Tanarro, Daniel Lozano-Ojalvo, Mónica Martínez-Blanco, Elena Molina, Rosina López-Fandiño
SCOPE: Egg is the second most frequent source of allergic reactions in children. Egg yolk (EY) amounts to one third in weight of a fresh whole egg, but its contribution to egg allergy has not been investigated in depth. This study assesses whether EY influences the capacity of egg white (EW) to sensitize and trigger allergic responses. METHODS AND RESULTS: BALB/c mice were exposed to EW, EY and their mixture, using models of orally (with and without adjuvant) and adjuvant-free intraperitoneally-induced allergy...
May 14, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29757492/investigation-of-variations-in-the-human-urine-metabolome-amongst-european-populations-an-exploratory-search-for-biomarkers-of-people-at-risk-of-poverty
#5
Alessia Trimigno, Bekzod Khakimov, Francesco Savorani, Leonardo Tenori, Vaiva Hendrixson, Alminas Čivilis, Marija Glibetic, Mirjana Gurinovic, Saara Pentikäinen, Janne Sallinen, Sara Garduno Diaz, Francesca Pasqui, Santosh Khokhar, Claudio Luchinat, Alessandra Bordoni, Francesco Capozzi, Søren Balling Engelsen
SCOPE: According to Eurostat 2016, approximately 119 million European citizens live at-risk-of-poverty (ROP). This subpopulation is highly diverse by ethnicity, age and culture in the different EU states, but they all have in common a low income, that could represent an increased risk of nutrients deficiencies due to poor nutritional habits. This study aims to investigate the human urine metabolome in the search of common biomarkers representing dietary deficiencies amongst European populations at ROP...
May 14, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29756679/effect-of-heat-processing-on-ige-reactivity-and-cross-reactivity-of-tropomyosin-and-other-allergens-of-asia-pacific-mollusc-species-identification-of-novel-sydney-rock-oyster-tropomyosin-sac-g-1
#6
Jennifer M Rolland, Nirupama P Varese, Jodie B Abramovitch, Jessica Anania, Roni Nugraha, Sandip Kamath, Anita Hazard, Andreas L Lopata, Robyn E O'Hehir
SCOPE: Shellfish allergy is an increasing global health priority, frequently affecting adults. Molluscs are an important shellfish group causing food allergy but knowledge of their allergens and cross-reactivity is limited. Optimal diagnosis of mollusc allergy enabling accurate advice on food avoidance is difficult. We characterized allergens of four frequently ingested Asia-Pacific molluscs: Sydney Rock Oyster (Saccostrea glomerata), Blue Mussel (Mytilus edulis), Saucer Scallop (Amusium balloti) and Southern Calamari (Sepioteuthis australis), examining cross-reactivity between species and with Blue Swimmer Crab tropomyosin, Por p 1...
May 14, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29750855/pharmacological-and-nutritional-effects-of-natural-coumarins-and-their-structure-activity-relationships
#7
REVIEW
Jing-Jing Zhu, Jian-Guo Jiang
Coumarins are fused benzene and pyrone ring systems with a wide spectrum of bioactivities including anti-tumor, anti-inflammation, antiviral and antibacterial effects. In this paper, the current development of coumarins-based drugs is introduced, and their structure-activity relationship is discussed by reviewing the relevant literatures published in the past twenty years. Coumarin molecules can be customized by the target site to prevent systemic side effects by virtue of structural modification. The ortho-phenolic hydroxyl on the benzene ring had remarkable antioxidant and anti-tumor activities...
May 11, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29750437/green-tea-liquid-consumption-alters-the-human-intestinal-and-oral-microbiome
#8
Xiaojie Yuan, Yong Long, Zhaohua Ji, Jie Gao, Ting Fu, Min Yan, Lei Zhang, Haixia Su, Weilu Zhang, Xiaohui Wen, Zhongshu Pu, Hui Chen, Yufei Wang, Xu Gu, Binyuan Yan, Kanakaraju Kaliannan, Zhongjun Shao
SCOPE: GTPs exerts anti-CRC activity. The intestinal microbiota and intestinal colonization by bacteria of oral origin has been implicated in colorectal carcinogenesis. GT modulates the composition of mouse gut microbiota harmonious with anticancer activity. Therefore, we investigated the effect of GTL consumption on the gut and oral microbiome in healthy volunteers (n = 12). METHODS AND RESULTS: 16S sequencing and PICRUSt analysis of both fecal and saliva samples (collected before intervention, after 2 weeks of GTL (400 ml/day) and after a washout period of one week) in healthy volunteers showed changes in microbial diversity and core microbiota and difference in clear classification (PLS-DA)...
May 11, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29738112/high-fat-diet-dysregulates-hypothalamic-pituitary-axis-gene-expression-levels-which-are-differentially-rescued-by-epa-and-dha-ethyl-esters
#9
Saame Raza Shaikh, Patti R Shaver, Brian M Shewchuk
SCOPE: Dietary fat composition can modulate gene expression in peripheral tissues in obesity. Observations of the dysregulation of growth hormone (GH) in obesity indicate that these effects extend to the hypothalamic-pituitary (H-P) axis. We thus determined whether specific high fat (HF) diets influenced the levels of Gh and other key gene transcripts in the H-P axis. METHODS AND RESULTS: C57BL/6 mice were fed a lean control diet or a HF diet in the absence or presence of OA, EPA or DHA ethyl esters...
May 8, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29733520/mango-mangifera-indica-l-polyphenols-ameliorate-functional-constipation-symptoms-in-humans-beyond-equivalent-amount-of-fiber
#10
Vinicius P Venancio, Hyemee Kim, Maritza A Sirven, Carmen D Tekwe, Gilson Honvoh, Stephen T Talcott, Susanne U Mertens-Talcott
SCOPE: Chronic constipation is a common gastrointestinal condition associated with intestinal inflammation and considerably impaired quality of life, affecting about 20% of Americans. Dietary fiber and laxatives aid in its treatment but do not fully address all symptoms, such as intestinal inflammation. Mango (Mangifera indica L.), a fiber- and polyphenol-rich fruit may provide anti-inflammatory effects in constipation. METHODS AND RESULTS: The 4-week consumption of mango fruit (300 g) or the equivalent amount of fiber was investigated in otherwise healthy human volunteers with chronic constipation that were randomly assigned to either group...
May 7, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29733507/high-fat-diets-composed-of-palm-stearin-and-olive-oil-equally-exacerbate-liver-inflammatory-damage-and-metabolic-stress-in-mice
#11
Elena Meidan, Yula Kolesnikov, Oren Tirosh
SCOPE: People with fatty liver could be subjected to acute infections such as sepsis. The aim of the study was to evaluate the effect of high fat diets (HFD) of olive oil and palm stearin on liver inflammation induced by lipopolysaccharides (LPS). METHODS AND RESULTS: C57BL/6J male mice were treated with high fat diets with different sources of oils: Palm stearin and olive oil for 8 weeks followed by LPS injection. The proinflammatory effect of olive oil was also studied using gavage treatment and i...
May 7, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29714053/sulforaphane-upregulates-the-heat-shock-protein-co-chaperone-chip-and-clears-amyloid-%C3%AE-and-tau-in-a-mouse-model-of-alzheimer-s-disease
#12
Siyoung Lee, Bo-Ryoung Choi, Jisung Kim, Frank M LaFerla, Jung Han Yoon Park, Jung-Soo Han, Ki Won Lee, Jiyoung Kim
SCOPE: Sulforaphane is an herbal isothiocyanate enriched in cruciferous vegetables. Here, we investigated whether sulforaphane modulates the production of amyloid-β (Aβ) and tau, the two main pathological factors in Alzheimer's disease (AD). METHODS AND RESULTS: A triple transgenic mouse model of AD (3 × Tg-AD) was used to study the effect of sulforaphane. Oral gavage of sulforaphane reduced protein levels of monomeric and polymeric forms of Aβ as well as tau and phosphorylated tau in 3 × Tg-AD mice...
April 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29714050/maternal-metabolomic-profile-and-fetal-programming-of-offspring-adiposity-identification-of-potentially-protective-lipid-metabolites
#13
Christian Hellmuth, Karen L Lindsay, Olaf Uhl, Claudia Buss, Pathik D Wadhwa, Berthold Koletzko, Sonja Entringer
SCOPE: The fetal programming paradigm posits that the origins of obesity can be traced, in part, to the intrauterine period of life. However, the mechanisms underlying fetal programming are not well understood, and few studies have measured offspring adiposity in the neonatal period. The aim of this study was to identify maternal metabolites, and their determinants, that are associated with neonatal adiposity. METHODS AND RESULTS: We applied a targeted metabolomics approach to analyze plasma samples collected across gestation from a well-characterized cohort of 253 pregnant women participating in a prospective study at the University of California, Irvine...
April 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29710405/in-vitro-fermentation-behaviour-of-isomalto-malto-polysaccharides-using-human-faecal-inoculum-indicates-prebiotic-potential
#14
Fangjie Gu, Klaudyna Borewicz, Bernadette Richter, Pieter H van der Zaal, Hauke Smidt, Pieter L Buwalda, Henk A Schols
SCOPE: This study characterized intestinal fermentation of isomalto/malto-polysaccharides (IMMPs), by monitoring degradation of IMMPs, production of short chain fatty acids (SCFAs), lactic acid and succinic acid as well as enzyme activity and microbiota composition. METHODS AND RESULTS: IMMP-94 (94% α-(1→6) glycosidic linkages), IMMP-96, IMMP-27 and IMMP-dig27 (IMMP-27 after removal of digestible starch segments) were fermented batchwise in vitro using human faecal inoculum...
April 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29710398/phenethyl-isothiocyanate-a-dual-activator-of-transcription-factors-nrf2-and-hsf1
#15
REVIEW
Sharadha Dayalan Naidu, Takafumi Suzuki, Masayuki Yamamoto, Jed W Fahey, Albena T Dinkova-Kostova
Cruciferous vegetables are rich sources of glucosinolates which are the biogenic precursor molecules of isothiocyanates (ITCs). The relationship between the consumption of cruciferous vegetables and chemoprotection has been widely documented in epidemiological studies. Phenethyl isothiocyanate (PEITC) occurs as its glucosinolate precursor gluconasturtiin in the cruciferous vegetable watercress (Nasturtium officinale). PEITC has multiple biological effects, including activation of cytoprotective pathways, such as those mediated by the transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) and the transcription factor heat shock factor 1 (HSF1), and can cause changes in the epigenome...
April 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29710384/resveratrol-prevents-the-development-of-hypertension-programmed-by-maternal-plus-post-weaning-high-fructose-consumption-through-modulation-of-oxidative-stress-nutrient-sensing-signals-and-gut-microbiota
#16
You-Lin Tain, Wei-Chia Lee, Kay L H Wu, Steve Leu, Julie Y H Chan
SCOPE: High-fructose (HF) intake, oxidative stress, nutrient-sensing signals, and gut microbiota dysbiosis are closely related to the development of hypertension. We investigated whether resveratrol can prevent hypertension induced by maternal plus post-weaning HF diets in adult offspring via the above-mentioned mechanisms. METHODS AND RESULTS: Female Sprague-Dawley rats received either a normal (ND) or 60% high-fructose (HF) diet during gestation and lactation...
April 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29710380/effects-of-postoperative-parenteral-nutrition-enhanced-by-multivitamin-on-metabolic-phenotype-in-postoperative-gastric-cancer-patients
#17
Zi-Jian Li, Wei Chen, Hua Jiang, Xiao-Yi Li, Sai-Nan Zhu, Xiao-Liu Liu
SCOPE: To investigated the effects of postoperative parenteral nutrition (PN) with multivitamins supplementation on oxidative stress and metabolism. METHODS AND RESULTS: The participants were randomly assigned in a 1:1 ratio to groups: total nutrient admixture (TNA)+ multivitamin (n = 14, Group A) and TNA+ normal saline (n = 16, Group B). The levels of blood vitamins, ILs and MDA were assessed and the dysregulation of metabolism was analyzed using nontargeted metabolite profiling...
April 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29704403/green-tea-polyphenols-mitigate-gliadin-mediated-inflammation-and-permeability-in-vitro
#18
Charlene B Van Buiten, Joshua D Lambert, Ryan J Elias
SCOPE: Green tea, a polyphenol-rich beverage, has been reported to mitigate a number of inflammatory and hypersensitivity disorders in laboratory models, and has been shown to moderate pathways related to food allergies in vitro. We sought to determine the impact of decaffeinated green tea extract (GTE) on the digestion of gliadin protein in vitro and the effect of physical interactions with GTE on the ability of gliadin to stimulate celiac disease-related symptoms in vitro. METHODS AND RESULTS: Complexation of GTE and gliadin in vitro was confirmed by monitoring increases in turbidity upon titration of GTE into a gliadin solution...
April 28, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29701903/impact-of-mir-140-deficiency-on-non-alcoholic-fatty-liver-disease
#19
Benjamin Wolfson, Pang-Kuo Lo, Yuan Yao, Linhao Li, Hongbing Wang, Qun Zhou
SCOPE: Loss of miR-140 has a pro-fibrotic effect in the mammary gland. This study aimed to investigate whether miR-140 loss and obesity act synergistically to promote non-alcoholic fatty liver disease, and to identify the underlying mechanisms. METHODS AND RESULTS: Liver tissues were isolated from lean-fat diet and high-fat diet fed wild-type and miR-140 knockout mice. Using molecular staining and immunohistochemistry techniques we identified increased development of non-alcoholic fatty liver disease (NAFLD) and fibrotic indicators in miR-140 knockout mice...
April 27, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29688623/in-vitro-and-in-vivo-inhibition-of-intestinal-glucose-transport-by-guava-psidium-guajava-extracts
#20
Ulrike Müller, Flora Stübl, Bettina Schwarzinger, Georg Sandner, Marcus Iken, Markus Himmelsbach, Clemens Schwarzinger, Nicole Ollinger, Verena Stadlbauer, Otmar Höglinger, Tobias Kühne, Peter Lanzerstorfer, Julian Weghuber
SCOPE: Known pharmacological activities of guava (Psidium guajava) include modulation of blood glucose levels. However, mechanistic details remain unclear in many cases. METHODS AND RESULTS: This study investigated the effects of different guava leaf and fruit extracts on intestinal glucose transport in vitro and on postprandial glucose levels in vivo. Substantial dose- and time-dependent glucose transport inhibition (up to 80%) was observed for both guava fruit and leaf extracts, at conceivable physiological concentrations in Caco-2 cells...
April 24, 2018: Molecular Nutrition & Food Research
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