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Virology Journal

Leonard N Binn, Erica A Norby, Ruth H Marchwicki, Richard G Jarman, Paul B Keiser, Jun Hang
BACKGROUND: Vesiviruses (family Caliciviridae) had been shown capable of invading a variety of host species, raising concern of their zoonotic potential. Since the 1980's, several canine caliciviruses (CaCV) isolates have been reported and are phylogenetically related to the vesiviruses with features distinct from both Vesicular exanthema of swine virus (VESV) and Feline calicivirus (FCV) species in phylogeny, serology and cell culture specificities. Etiological studies of canine diseases in dogs used for military services and laboratory studies were conducted in 1963-1978 at the Walter Reed Army Institute of Research...
February 23, 2018: Virology Journal
Supaporn Wacharapluesadee, Prateep Duengkae, Aingorn Chaiyes, Thongchai Kaewpom, Apaporn Rodpan, Sangchai Yingsakmongkon, Sininat Petcharat, Patcharakiti Phengsakul, Pattarapol Maneeorn, Thiravat Hemachudha
BACKGROUND: Bats are natural reservoirs for several highly pathogenic and novel viruses including coronaviruses (CoVs) (mainly Alphacoronavirus and Betacoronavirus). Lyle's flying fox (Pteropus lylei)'s roosts and foraging sites are usually in the proximity to humans and animals. Knowledge about age-specific pattern of CoV infection in P. lylei, prevalence, and viral shedding at roosts and foraging sites may have an impact on infection-age-structure model to control CoV outbreak. METHODS: P...
February 20, 2018: Virology Journal
Monique Figueiredo Teixeira, Meritxell Sabidó, André Luiz Leturiondo, Cynthia de Oliveira Ferreira, Kátia Luz Torres, Adele Schwartz Benzaken
BACKGROUND: Human immunodeficiency virus (HIV)-positive women have a high prevalence of human papillomavirus (HPV), and are infected with a broader range of HPV types than HIV-negative women. We aimed to determine the prevalence of cervical cytologic abnormalities, high-risk (HR)-HPV prevalence, type distribution according to the severity of cervical lesions and CD4 cell count and identify factors associated with HR-HPV infection among women living with HIV in Manaus, Amazonas. METHODS: We enrolled 325 women living with HIV that attended an infectious diseases referral hospital...
February 17, 2018: Virology Journal
Davide Lelli, Alice Prosperi, Ana Moreno, Chiara Chiapponi, Anna Maria Gibellini, Paola De Benedictis, Stefania Leopardi, Enrica Sozzi, Antonio Lavazza
BACKGROUND: Rhabdoviridae is one of the most ecologically diverse families of RNA viruses which can infect a wide range of vertebrates and invertebrates. Bats, among mammals, are pointed to harbor a significantly higher proportion of unknown or emerging viruses with zoonotic potential. Herein, we report the isolation of a novel rhabdovirus, detected in the framework of a virological survey on bats implemented in North Italy. METHODS: Virus isolation and identification were performed on samples of 635 bats by using cell cultures, negative staining electron microscopy and PCRs for different viruses...
February 17, 2018: Virology Journal
Cyprien Beraud, Morgane Lemaire, Danielle Perez Bercoff
The cytoplasmic domain of lentiviral Envelopes (EnvCD) ensures Env incorporation into nascent virions and regulates Env trafficking to and from the plasma membrane. It has also been reported to promote transcription from the viral LTR both directly and indirectly. Noticeably, the HIV-1 and SIVmac239 EnvCDs were described to trigger nuclear translocation of NF-κB (Postler, Cell Host Microbes 2012). Given the paramount importance of identifying viral and host factors regulating HIV transcription, cellular signaling pathways and latency, and given that viral replication capacity is dependent on Env, we asked whether HIV EnvCDs from different HIV-1 subtypes differently modulated NF-κB...
February 17, 2018: Virology Journal
Ana Carolina Gomes Jardim, Jacqueline Farinha Shimizu, Paula Rahal, Mark Harris
Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide. There is no effective vaccine for prevention of HCV infection; however, a number of drugs are available for the treatment of infection. The availability of direct-acting antivirals (DAAs) has dramatically improved therapeutic options for HCV genotype 1. However, the high costs and potential for development of resistance presented by existing treatment demonstrate the need for the development of more efficient new antivirals, or combination of therapies that target different stages of the viral lifecycle...
February 13, 2018: Virology Journal
Fanfeng Meng, Qiuchen Li, Yawen Zhang, Zhihui Zhang, Sibao Tian, Zhizhong Cui, Shuang Chang, Peng Zhao
BACKGROUND: In spite of the purification of the laying hens and broilers of avian leukosis virus (ALV) has made remarkable achievements, the infection of ALV was still serious in Chinese indigenous chickens. METHODS: In order to assess the epidemic state of avian leukosis virus in indigenous chickens in China, 10 novel strains of ALV subgroup J (ALV-J), named JS16JH01 to JS16JH10, were isolated and identified by virus isolation and immunofluorescence antibody assays from a Chinese local breed farm with a sporadic incidence of tumors...
February 13, 2018: Virology Journal
Dianjun Cao, Yan-Yan Ni, Xiang-Jin Meng
BACKGROUND: Genotype 3 hepatitis E virus (HEV) infection is generally associated with mild disease. However, recently eight genotype 3 HEV isolates were identified from patients with severe hepatitis. Importantly, three mutations (S605P, I978V and V1213A) in these genotype 3 isolates were found to be typical of genotype 4 HEV, which is sometime associated with more severe hepatitis. Therefore in this study we seek to determine if these unique mutations contribute to enhanced virus replication and thus potentially severe disease...
February 8, 2018: Virology Journal
Tesfaye Gelanew, Elizabeth Hunsperger
BACKGROUND: Dengue, caused by one of the four serologically distinct dengue viruses (DENV-1 to - 4), is a mosquito-borne disease of serious global health significance. Reliable and cost-effective diagnostic tests, along with effective vaccines and vector-control strategies, are highly required to reduce dengue morbidity and mortality. Evaluation studies revealed that many commercially available NS1 antigen (Ag) tests have limited sensitivity to DENV-4 serotype compared to the other three serotypes...
February 6, 2018: Virology Journal
Yu Du, Guangxue Zhang, Zhijun Liu
BACKGROUND: Human cytomegalovirus (HCMV) infection is closely associated with coronary heart disease. In 1987, Adam et al. were the first to report an association between HCMV infection and atherosclerosis (AS), and later, many serum epidemiology and molecular biology studies showed that HCMV-infected endothelial cells play an important role in the development of AS. As patients with HCMV are generally susceptible to coronary heart disease, and with the increasing elderly population, a review of recent studies focusing on the relationships of HCMV infection and coronary heart disease is timely and necessary...
February 6, 2018: Virology Journal
C Prezioso, D Scribano, D M Rodio, C Ambrosi, M Trancassini, A T Palamara, V Pietropaolo
John Cunningham virus (JCV) is a human neurotropic polyomavirus whose replication in the Central Nervous System (SNC) induces the fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML). JCV propagation and PML investigation have been severely hampered by the lack of an animal model and cell culture systems to propagate JCV have been very limited in their availability and robustness. We previously confirmed that JCV CY strain efficiently replicated in COS-7 cells as demonstrated by the progressive increase of viral load by quantitative PCR (Q-PCR) during the time of transfection and that archetypal regulatory structure was maintained, although two characteristic point mutations were detected during the viral cycle...
February 5, 2018: Virology Journal
Tetsuo Sato, Kazuki Oroku, Yoshiyuki Ohshima, Yoshiaki Furuya, Chihiro Sasakawa
BACKGROUND: Porcine epidemic diarrhea (PED) is a lethal infectious disease in suckling piglets with symptoms including watery diarrhea caused by PED virus (PEDV). Since the late 1990's, live vaccines based on genogroup 1 virus have been used in Japan, and a significant amount of the vaccine has been used even after new genogroups invaded in 2013. In this study, we evaluated the effect of a conventional PED live vaccine on a newly prevalent genogroup 2 field strain in experimental and field situations...
February 2, 2018: Virology Journal
Yinjie Niu, Lili Zhao, Baihan Liu, Jingli Liu, Fan Yang, Haichang Yin, Hong Huo, Hongyan Chen
BACKGROUND: Goose parvovirus (GPV) causes acute enteritis, hepatitis, myocarditis and high morbidity and mortality in geese and ducks. GPV H strain was isolated from a Heilongjiang goose farm where the geese were showing signs of hemorrhage in the brain, liver, and intestinal tract. In this study, we explored the genetic diversity among waterfowl parvovirus isolates and the pathological characteristics of GPV H in Shaoxing ducklings. METHODS: The complete capsid protein (VP) and non-structural (NS) sequences of the isolated H strain were sequenced, and phylogenetic trees of VP and NS were constructed in MEGA version 5...
February 1, 2018: Virology Journal
Fabien Zoulim, Christophe Moreno, Samuel S Lee, Peter Buggisch, Andrzej Horban, Eric Lawitz, Chris Corbett, Oliver Lenz, Bart Fevery, Thierry Verbinnen, Umesh Shukla, Wolfgang Jessner
BACKGROUND: Simeprevir is approved with pegylated interferon and ribavirin (PR) for chronic hepatitis C virus (HCV) genotype (GT) 1 and GT4 infection in the USA and the European Union. METHODS: This 3-year follow-up study assessed the durability of sustained virologic response (SVR) (undetectable HCV RNA 12 or 24 weeks after treatment end), and evaluated the persistence of treatment-emergent NS3/4A protease inhibitor resistance in patients not achieving SVR following treatment with simeprevir plus PR in the parent study...
January 30, 2018: Virology Journal
Robert Fux, Christina Söckler, Ellen Kathrin Link, Christine Renken, Roman Krejci, Gerd Sutter, Mathias Ritzmann, Matthias Eddicks
BACKGROUND: The occurrence of the novel porcine circovirus type 3 (PCV3) was reported from the Americas, Asia and Europe. Although this virus was detected in association with various clinical syndromes in pigs, its role as possible swine pathogen remains unclear. PCV3 was detected with high prevalence in Polish farms, but to date no genome sequences were available from European PCV3 strains. METHODS: We collected 1060 serum samples from piglets at the age of 20-24 weeks from 53 farms distributed all over Germany...
January 29, 2018: Virology Journal
Reina Teresa Martínez, Mariana Martins Severo de Almeida, Rosalba Rodriguez, Athos Silva de Oliveira, Fernando Lucas Melo, Renato Oliveira Resende
The Tomato chlorotic spot virus (TCSV) was first reported in the 1980s, having its occurrence limited to Brazil and Argentina. Due to an apparent mild severity in the past, molecular studies concerning TCSV were neglected. However, TCSV has disseminated over the USA and Caribbean countries. In Dominican Republic TCSV has been recently reported on important cultivated crops such as pepper and beans. In this work, we provide the first complete genome of a TCSV isolate from symptomatic plants in Dominican Republic, which was obtained by high-throughput sequencing...
January 26, 2018: Virology Journal
Ligia Fernandes Abdalla, João Hugo Abdalla Santos, Renata Teodora Jales Barreto, Erick Martins E Souza, Fabrício Fonseca D'Assunção, Márcio Aurélio Borges, Valdinete Alves Nascimento, George Allan Villarouco da Silva, Victor Costa de Souza, Rajendranath Ramasawmy, Ana Carolina Campi-Azevedo, Jordana Graziela Coelho-Dos-Reis, Lis Ribeiro do Vale Antonelli, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Felipe Gomes Naveca
BACKGROUND: Zika virus is an emerging arbovirus of the family Flaviviridae and genus Flavivirus that until 2007 was restricted to a few cases of mild illness in Africa and Asia. CASE PRESENTATION: We report a case of atrial fibrillation disclosed during an acute Zika virus infection in a 49-year-old man. Different biological samples were analyzed for the molecular diagnosis of Zika by real-time PCR, however only the saliva specimen was positive. The patient's wife tested positive in the serum sample, although she was an asymptomatic carrier...
January 25, 2018: Virology Journal
Ana Cláudia Dos S P Andrade, Thalita S Arantes, Rodrigo A L Rodrigues, Talita B Machado, Fábio P Dornas, Melissa F Landell, Cinthia Furst, Luiz G A Borges, Lara A L Dutra, Gabriel Almeida, Giliane de S Trindade, Ivan Bergier, Walter Abrahão, Iara A Borges, Juliana R Cortines, Danilo B de Oliveira, Erna G Kroon, Jônatas S Abrahão
BACKGROUND: Since the discovery of giant viruses infecting amoebae in 2003, many dogmas of virology have been revised and the search for these viruses has been intensified. Over the last few years, several new groups of these viruses have been discovered in various types of samples and environments.In this work, we describe the isolation of 68 giant viruses of amoeba obtained from environmental samples from Brazil and Antarctica. METHODS: Isolated viruses were identified by hemacolor staining, PCR assays and electron microscopy (scanning and/or transmission)...
January 24, 2018: Virology Journal
Mohamed A Ahmed, Manal E Sharif, Duria A Rayis, Abubakr M Nasr, Ishag Adam
BACKGROUND: Previous published studies have reported conflicting results of association between hepatitis B virus (HBV) infection and preeclampsia. There was no published data on HBV and preeclampsia in Africa including Sudan. The aim of the present study was to investigate the association between HBsAg seropositivity and preeclampsia. METHODS: A case -controls study (200 women in each arm) was conducted at Saad Abualila Maternity Hospital, Khartoum, Sudan. The cases were women with preeclampsia and the controls were healthy pregnant women...
January 22, 2018: Virology Journal
Xuelian Meng, Ruixue Deng, Xueliang Zhu, Zhidong Zhang
BACKGROUND: The specific and dynamic interaction between the hemagglutinin (H) and fusion (F) proteins of morbilliviruses is a prerequisite for the conformational rearrangements and membrane fusion during infection process. The two heptad repeat regions (HRA and HRB) of F protein are both important for the triggering of F protein. METHODS: In this study, the direct interactions of Peste des petits ruminants virus (PPRV) H with F, HRA and HRB were quantitatively evaluated using biosensor surface plasmon resonance (SPR)...
January 22, 2018: Virology Journal
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