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Nutrition & Metabolism

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https://www.readbyqxmd.com/read/29344054/the-carnitine-status-does-not-affect-the-contractile-and-metabolic-phenotype-of-skeletal-muscle-in-pigs
#1
Daniel Kaup, Janine Keller, Erika Most, Joachim Geyer, Klaus Eder, Robert Ringseis
Background: Recently, supplementation of L-carnitine to obese rats was found to improve the carnitine status and to counteract an obesity-induced muscle fiber transition from type I to type II. However, it has not been resolved if the change of muscle fiber distribution induced in obese rats and the restoration of the "normal" muscle fiber distribution, which is found in lean rats, in obese rats by supplemental L-carnitine is causally linked with the carnitine status. In the present study we hypothesized that fiber type distribution in skeletal muscle is dependent on carnitine status...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29312456/association-of-sleep-duration-with-apolipoproteins-and-the-apolipoprotein-b-a1-ratio-the-china-health-and-nutrition-survey
#2
Huihui Ren, Zhelong Liu, Xinrong Zhou, Gang Yuan
Background: Short sleep duration has been related to established cardiovascular risk factors, likely obesity, diabetes, hypertension and dyslipidaemia. However, to the best of our knowledge, the associations between sleep duration and apolipoprotein concentrations and their ratios have not been investigated to date. This study aimed to explore the independent relationship of sleep duration with apolipoprotein (apo) A1, apoB and the apoB/apoA1 ratio in a Chinese adult population. Methods: Data from 7381 participants, aged 18 to 75 years, from the National Health and Nutrition Survey 2009 were analysed in this cross-sectional study...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29299042/the-effects-of-vitamin-d-and-omega-3-fatty-acids-co-supplementation-on-biomarkers-of-inflammation-oxidative-stress-and-pregnancy-outcomes-in-patients-with-gestational-diabetes
#3
Maryamalsadat Razavi, Mehri Jamilian, Mansooreh Samimi, Faraneh Afshar Ebrahimi, Mohsen Taghizadeh, Reza Bekhradi, Elahe Seyed Hosseini, Hamed Haddad Kashani, Maryam Karamali, Zatollah Asemi
Background: This study was carried out to determine the effects of vitamin D and omega-3 fatty acids co- supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes (GDM) patients. Methods: This randomized, double-blind, placebo-controlled trial was conducted among 120 GDM women. Participants were randomly divided into four groups to receive: 1) 1000 mg omega-3 fatty acids containing 180 mg eicosapentaenoic acid (EPA) and 120 mg docosahexaenoic acid (DHA) twice a day + vitamin D placebo (n = 30); 2) 50,000 IU vitamin D every 2 weeks + omega-3 fatty acids placebo (n = 30); 3) 50,000 IU vitamin D every 2 weeks + 1000 mg omega-3 fatty acids twice a day (n = 30) and 4) vitamin D placebo + omega-3 fatty acids placebo (n = 30) for 6 weeks...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29299041/ascorbic-acid-promotes-3t3-l1-cells-adipogenesis-by-attenuating-erk-signaling-to-upregulate-the-collagen-vi
#4
Chuanguo Liu, Kun Huang, Guorong Li, Pingping Wang, Chang Liu, Congcong Guo, Zongguo Sun, Jie Pan
Background: Type VI collagen is supposed to be a regulation factor in adipogenesis. This study aimed to assess the promoting effect of vitamin C (VC) on adipogenic differentiation of preadipocytes as well as its mechanism. Methods: Five sets of different combinations of chemicals were used to inhibit synthesis of type I to VI collagens, blocking ERK1/2 phosphorylation during adipogenesis of 3T3-L1 preadipocytes. Furthermore, to explore whether collagen VI plays a critical role during adipogenesis, specific knockdown of collagen VI was performed by using RNA interference...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29299040/the-metabolism-and-significance-of-homocysteine-in-nutrition-and-health
#5
REVIEW
Avinash Kumar, Henry A Palfrey, Rashmi Pathak, Philip J Kadowitz, Thomas W Gettys, Subramanyam N Murthy
An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in 1969. Hcy is a sulfur containing amino acid derived from the essential amino acid methionine (Met). Hyperhomocysteinemia (HHcy) was subsequently shown in several age-related pathologies such as osteoporosis, Alzheimer's disease, Parkinson's disease, stroke, and cardiovascular disease (CVD). Also, Hcy is associated with (but not limited to) cancer, aortic aneurysm, hypothyroidism and end renal stage disease to mention some...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29234452/genetic-variations-of-cholesteryl-ester-transfer-protein-and-diet-interactions-in-relation-to-lipid-profiles-and-coronary-heart-disease-a-systematic-review
#6
REVIEW
Parvin Mirmiran, Zohre Esfandiar, Firoozeh Hosseini-Esfahani, Gelareh Koochakpoor, Maryam S Daneshpour, Bahar Sedaghati-Khayat, Fereidoun Azizi
Data on diet-genotype interactions in the prevention or treatment of dyslipidemia have increased remarkably. This systematic review aimed to assess nutrigenetic studies regarding the modulating effect of diet on cholesteryl ester transfer protein (CETP) polymorphisms in relation to metabolic traits. Data were collected through studies published between 2000 and SEP. 2016 using five electronic databases. The quality of eligible studies was assessed using a 12-item quality checklist, derived from the STrengthening the REporting of Genetic Association Studies (STREGA) statement...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29226913/correction-to-antiobesity-potential-of-piperonal-promising-modulation-of-body-composition-lipid-profiles-and-obesogenic-marker-expression-in-hfd-induced-obese-rats
#7
Balaji Meriga, Brahmanaidu Parim, Venkata Rao Chunduri, Ramavat Ravindar Naik, Harishankar Nemani, Pothani Suresh, Saravanan Ganapathy, V V Sathibabu Uddandrao
[This corrects the article DOI: 10.1186/s12986-017-0228-9.].
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29209405/retroconversion-is-a-minor-contributor-to-increases-in-eicosapentaenoic-acid-following-docosahexaenoic-acid-feeding-as-determined-by-compound-specific-isotope-analysis-in-rat-liver
#8
Adam H Metherel, Raphaël Chouinard-Watkins, Marc-Olivier Trépanier, R J Scott Lacombe, Richard P Bazinet
Dietary docosahexaenoic acid (DHA, 22:6n-3) not only increases blood and tissue levels of DHA, but also eicosapentaenoic acid (EPA, 20:5n-3). It is generally believed that this increase is due to DHA retroconversion to EPA, however, a slower conversion of α-linolenic acid (ALA, 18:3n-3) derived EPA to downstream metabolic products (i.e. slower turnover of EPA) is equally plausible. In this study, 21-day old Long Evans rats were weaned onto an ALA only or DHA + ALA diet for 12 weeks. Afterwards, livers were collected and the natural abundance 13C-enrichment was determined by compound specific isotope analysis (CSIA) of liver EPA by isotope ratio mass-spectrometry and compared to dietary ALA and DHA 13C-enrichment...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29209404/response-to-discrepancies-in-publications-related-to-hmb-fa-and-atp-supplementation
#9
Jacob M Wilson
Gentles and Phillips have submitted questions regarding three recent papers investigating ATP, HMB and the combination. The questions pertaining to the homogeneity of subjects' characteristics between the three different published papers, and why there appears to be differences in the number of subjects in placebo groups across studies. This response addresses each of these issues and demonstrates that there are no discrepancies between papers but rather a misunderstanding of the papers previously published...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29204182/baseline-type-2-diabetes-had-a-significant-association-with-elevated-high-sensitivity-cardiac-troponin-t-levels-in-chinese-community-dwelling-population-a-5-year-prospective-analysis
#10
Shihui Fu, Rongjie Jin, Leiming Luo, Ping Ye
Background: The present analysis was designed to investigate the association of type 2 diabetes (T2D) with high sensitivity cardiac troponin T (hs-cTnT) during the 5 years of follow-up, and explore which one of fasting blood glucose (FBG) and postprandial blood glucose (PBG) is a determinant of this association in Chinese community-dwelling population. Methods: This prospective community-based analysis was conducted based on 730 participants without coronary artery disease and hs-cTnT values ≥14 pg/mL receiving two measurements of hs-cTnT levels at baseline and follow-up of 5 years...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29176994/antiobesity-potential-of-piperonal-promising-modulation-of-body-composition-lipid-profiles-and-obesogenic-marker-expression-in-hfd-induced-obese-rats
#11
Balaji Meriga, Brahmanaidu Parim, Venkata Rao Chunduri, Ramavat Ravindar Naik, Harishankar Nemani, Pothani Suresh, Saravanan Ganapathy, Satthi Babu Vvu
Background: Black pepper or Piper nigrum is a well-known spice, rich in a variety of bioactive compounds, and widely used in many cuisines across the world. In the Indian traditional systems of medicine, it is used to treat gastric and respiratory ailments. The purpose of this investigation is to study the antihyperlipidemic and antiobesity effects of piperonal in high-fat diet (HFD)-induced obese rats. Methods: Piperonal, an active constituent of Piper nigrum seeds, was isolated and confirmed by HPLC, 1H and 13C NMR spectroscopy...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29176993/an-excess-dietary-vitamin-e-concentration-does-not-influence-nrf2-signaling-in-the-liver-of-rats-fed-either-soybean-oil-or-salmon-oil
#12
Klaus Eder, Marina Siebers, Erika Most, Susan Scheibe, Norbert Weissmann, Denise K Gessner
Background: Reactive oxygen species (ROS) are known to stimulate the activation of nuclear factor-erythroid 2-related factor-2 (Nrf2), the key regulator of the antioxidant and cytoprotective defense system in the body. The hypothesis underlying this study was that high dietary concentrations of vitamin E suppress Nrf2 activation, and thus could weaken the body's antioxidative and cytoprotective capacity. As the effect of vitamin E on Nrf2 pathway might be influenced by concentrations of fatty acids susceptible to oxidation in the diet, we used also diets containing either soybean oil as a reference oil or salmon oil as a source of oil rich in n-3 polyunsatuated fatty acids...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29167695/total-energy-expenditure-of-10-to-12-year-old-japanese-children-measured-using-the-doubly-labeled-water-method
#13
Keisuke Komura, Satoshi Nakae, Kazufumi Hirakawa, Naoyuki Ebine, Kazuhiro Suzuki, Haruo Ozawa, Yosuke Yamada, Misaka Kimura, Kojiro Ishii
Background: To establish Japanese children's estimated energy requirements, total energy expenditure (TEE) data measured using the doubly labeled water (DLW) method is needed. This study aimed to 1) obtain basic TEE data from Japanese children measured using DLW (TEEDLW), 2) compare TEEDLW with TEE estimated by various estimation formulas to calculate their accuracy, and 3) develop a new equation to estimate TEE using body composition and pedometers. Methods: TEE was measured using DLW in 56 10- to 12-year-old Japanese children (33 boys, 23 girls)...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29158770/does-the-enterolactone-enl-affect-fatty-acid-transporters-and-lipid-metabolism-in-liver
#14
Krzysztof Drygalski, Klaudia Berk, Tomasz Charytoniuk, Nicoletta Iłowska, Bartłomiej Łukaszuk, Adrian Chabowski, Karolina Konstantynowicz-Nowicka
Background: NAFLD as a result of inappropriate diet and obesity, may progress to sever conditions such as: type 2 diabetes mellitus or steatohepatitis, and has recently become a prevalent topic of numerous investigations. Due to its dangerous aftermaths, finding new substances, such as polyphenols and their derivatives, which might reduce liver steatosis is the main target of research into NAFLD treatment. Hence, the aim of the present study was to evaluate the effect(s) of enterolactone (ENL), a metabolite of secoisolariciresinol (SECO), on lipid metabolism together with changes in the expression of fatty acid transporters in fatty liver...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29118818/folic-acid-prevents-cardiac-dysfunction-and-reduces-myocardial-fibrosis-in-a-mouse-model-of-high-fat-diet-induced-obesity
#15
Wei Li, Renqiao Tang, Shengrong Ouyang, Feifei Ma, Zhuo Liu, Jianxin Wu
Background: Folic acid (FA) is an antioxidant that can reduce reactive oxygen species generation and can blunt cardiac dysfunction during ischemia. We hypothesized that FA supplementation prevents cardiac fibrosis and cardiac dysfunction induced by obesity. Methods: Six-week-old C57BL6/J mice were fed a high-fat diet (HFD), normal diet (ND), or an HFD supplemented with folic acid (FAD) for 14 weeks. Cardiac function was measured using a transthoracic echocardiographic exam...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29118817/maternal-high-fat-diet-impairs-glucose-metabolism-%C3%AE-cell-function-and-proliferation-in-the-second-generation-of-offspring-rats
#16
Yan-Hong Huang, Ting-Ting Ye, Chong-Xiao Liu, Lei Wang, Yuan-Wen Chen, Yan Dong
Background: This study aimed to assess the impact of perinatal high-fat (HF) diet in female Sprague-Dawley rats (F0) on glucose metabolism and islet function in their early life of second-generation of offspring (F2). Methods: F0 rats were fed with a standard chow (SC) or HF diet for 8 weeks before mating, up to termination of lactation for their first-generation of offspring (F1-SC and F1-HF). F1 females were mated with normal males at the age of week 11, and producing F2 offspring (F2-SC, F2-HF)...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29075307/identification-of-the-principal-transcriptional-regulators-for-low-fat-and-high-fat-meal-responsive-genes-in-small-intestine
#17
Octave Mucunguzi, Aicha Melouane, Abdelaziz Ghanemi, Mayumi Yoshioka, André Boivin, Ezequiel-Luis Calvo, Jonny St-Amand
BACKGROUND: High-fat (HF) diet is a well-known cause of obesity. To identify principle transcriptional regulators that could be therapeutic targets of obesity, we investigated transcriptomic modulation in the duodenal mucosa following low-fat (LF) and HF meal ingestion. METHODS: Whereas one group of mice was sacrificed after fasting, the others were fed ad libitum with LF or HF meal, and sacrificed 30 min, 1 h and 3 h after the beginning of the meal. A transcriptome analysis of the duodenal mucosa of the 7 groups was conducted using both microarray and serial analysis of gene expression (SAGE) method followed by an Ingenuity Pathways Analysis (IPA)...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29075306/postprandial-low-grade-inflammation-does-not-specifically-require-tlr4-activation-in-the-rat
#18
Dominique Hermier, Véronique Mathé, Annaïg Lan, Clélia Santini, Annie Quignard-Boulangé, Jean-François Huneau, François Mariotti
BACKGROUND: Toll-like receptor 4 (TLR4), an innate immune receptor, is suspected to play a key role in the postprandial inflammation that is induced by a high-fat meal rich in saturated fatty acids (SFA). Our objective was to test this hypothesis by using a specific competitive inhibitor of TLR4 (INH) vs vehicle (VEH) administered immediately before a high-SFA meal in rats. METHODS: First, in a cross-over kinetic study of 12 rats receiving INH and VEH i.v. 10 min before the test meal, we measured plasma inflammatory and vascular markers for 6 h...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29051770/serum-alanine-aminotransferase-aspartate-aminotransferase-ratio-is-one-of-the-best-markers-of-insulin-resistance-in-the-chinese-population
#19
Li Zhao, Jing Cheng, Yingchao Chen, Qin Li, Bing Han, Yi Chen, Fangzhen Xia, Chi Chen, Dongping Lin, Xuemei Yu, Ningjian Wang, Yingli Lu
BACKGROUND: The alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio is reportedly associated with insulin resistance (IR). However, few studies have explored the relationship between the ALT/AST ratio and IR in the Chinese population. Here, we aimed to explore whether the ALT/AST ratio is associated and, if so, to what extent, with IR in the Chinese population as categorized by waist circumference (WC). METHODS: Our data were obtained from the SPECT-China study, a cross-sectional survey on the prevalence of metabolic diseases and risk factors in East China from 2014 to 2015...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29026429/markers-of-neuroprotection-of-combined-epa-and-dha-provided-by-fish-oil-are-higher-than-those-of-epa-nannochloropsis-and-dha-schizochytrium-from-microalgae-oils-in-wistar-rats
#20
Paula A Lopes, Narcisa M Bandarra, Susana V Martins, Joana Martinho, Cristina M Alfaia, Marta S Madeira, Carlos Cardoso, Cláudia Afonso, Maria C Paulo, Rui M A Pinto, José L Guil-Guerrero, José A M Prates
BACKGROUND: To overcome the current overexploitation of fish rich in n-3 long chain polyunsaturated fatty acids (LCPUFA), microalgae have become a promising marine lipid source. The purpose of this study was to assess eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), isolated or combined from distinct marine origins, on the promotion of neuroprotective effects. METHODS: The experiment lasted for 10 weeks and involved 32 Wistar rats, divided into 4 diets (n = 8): a diet rich in milk fat was taken as control (Milk Fat) and compared to n-3 LCPUFA enriched diets, either in EPA + DHA form through fish oil (Fish Oil), or EPA through Nannochloropsis oil (Nanno), or DHA through Schizochytrium oil (Schyzo), while maintaining Milk Fat incorporation...
2017: Nutrition & Metabolism
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