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Nutrition & Metabolism

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https://www.readbyqxmd.com/read/29760761/a-randomized-trial-of-the-effects-of-flaxseed-to-manage-constipation-weight-glycemia-and-lipids-in-constipated-patients-with-type-2-diabetes
#1
Noureddin Soltanian, Mohsen Janghorbani
Background: To compare the effects of baked flaxseed versus those who received a placebo on constipation symptom scores, weight, glycemic and lipid control in constipated patients with type 2 diabetes (T2D). Methods: In a single-blinded, randomized controlled trial, 53 constipated patients with T2D with body mass index (BMI) 20.5-48.9 kg/m2 received either 10 g of flaxseed pre-mixed in cookies twice per day or placebo cookies for 12 weeks. The constipation symptom scores, BMI, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), and lipid profile were determined at the beginning and end of 4, 8, and 12-week period...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29755576/cold-pressed-minke-whale-oil-reduces-circulating-ldl-vldl-cholesterol-lipid-oxidation-and-atherogenesis-in-apolipoprotein-e-deficient-mice-fed-a-western-type-diet-for-13-weeks
#2
Mari Johannessen Walquist, Svein Kristian Stormo, Bjarne Østerud, Edel O Elvevoll, Karl-Erik Eilertsen
Background: Long-chain n3-polyunsaturated fatty acids (LC n3-PUFA) are well known for their anti-inflammatory activity and their impact on cardiovascular disease. Cold-pressed whale oil (CWO) has half the amount of LC n3-PUFA compared to cod liver oil (CLO). Still, there has been observed more pronounced beneficial effects on cardiovascular disease markers from intake of CWO compared to intake of CLO in human intervention studies. Extracts from CWO deprived of fatty acids have also been shown to display antioxidative and anti-inflammatory effects in vitro...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29755575/waist-hip-ratio-related-genetic-loci-are-associated-with-risk-of-impaired-fasting-glucose-in-chinese-children-a-case-control-study
#3
Qi-Ying Song, Xiang-Rui Meng, Anke Hinney, Jie-Yun Song, Tao Huang, Jun Ma, Hai-Jun Wang
Background: The meta-analyses of genome-wide association studies identified several waist-hip ratio (WHR) related loci in individuals of European ancestry. Since the pattern of fat distribution and the relationship between fat distribution and glucose metabolism disturbance in Chinese are different from those in Europeans, the present study aimed to explore the individual and cumulative effects of WHR-related loci on glycemic phenotypes in Chinese children. Methods: A total of 2030 children were recruited from two independent studies...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29755574/branched-chain-amino-acids-in-health-and-disease-metabolism-alterations-in-blood-plasma-and-as-supplements
#4
REVIEW
Milan Holeček
Branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) are essential amino acids with protein anabolic properties, which have been studied in a number of muscle wasting disorders for more than 50 years. However, until today, there is no consensus regarding their therapeutic effectiveness. In the article is demonstrated that the crucial roles in BCAA metabolism play: (i) skeletal muscle as the initial site of BCAA catabolism accompanied with the release of alanine and glutamine to the blood; (ii) activity of branched-chain keto acid dehydrogenase (BCKD); and (iii) amination of branched-chain keto acids (BCKAs) to BCAAs...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29743930/lxr%C3%A9-participates-in-the-mtor-s6k1-srebp-1c-signaling-pathway-during-sodium-palmitate-induced-lipogenesis-in-hepg2-cells
#5
Youping Zhou, Shengjie Yu, Can Cai, Li Zhong, Huihong Yu, Wei Shen
Background: The aim of this study was to investigate how the signaling pathway downstream of mTOR/S6K1 contributes to the regulation of SREBP-1c expression during lipogenesis in HepG2 cells. Methods: The model of steatosis was established using human hepatocytes HepG2 and inducting them with sodium palmitate. mTOR, S6K1 and LXRα were inhibited by rapamycin, PF-4708671 and siRNA-LXRα, respectively. After a variety of different treatment, the levels of intracellular triglycerides, the accumulation of lipid droplets and the expression levels of related genes were detected...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29743929/neonatal-overfeeding-induced-glucocorticoid-overexposure-accelerates-hepatic-lipogenesis-in-male-rats
#6
Fan Yang, Yanyan Dai, Cuiting Min, Xiaonan Li
Background: Postnatal overfeeding activates tissue glucocorticoid (GC) activity by up-regulating 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) and increasing sensitivity to high-fat (HF) diet-induced non-alcoholic fatty liver disease (NAFLD). The present study aimed to evaluate the effects of postnatal overfeeding on GC regulation and lipogenesis in the liver and to observe the impact of GC on hepatocyte lipid metabolism. Methods: In vivo , Male Sprague-Dawley rat pup litters were adjusted to litter sizes of three (small litter, SL) or ten (normal litter, NL) on postnatal day 3 and then given standard chow from postnatal week 3 (W3) to W13...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29721032/iron-physiological-requirements-in-chinese-adults-assessed-by-the-stable-isotope-labeling-technique
#7
Jie Cai, Tongxiang Ren, Yuhui Zhang, Zhilin Wang, Lingyan Gou, Zhengwu Huang, Jun Wang, Jianhua Piao, Xiaoguang Yang, Lichen Yang
Background: Iron is a kind of essential trace mineral in the human body, while the studies on its physiological requirement are very limited recently, especially in China. And most studies were performed with the radioisotope tracer technique, which was harmful to health. This study aimed to first get the value of iron physiological requirements in Chinese adults assessed by the stable isotope labeling technique. Methods: Forty-four eligible young Chinese healthy adults were randomly recruited from the Bethune Military Medical College (Shijiazhuang, Hebei, China) between January 2010 and March 2011, and 19 subjects were included in the final data analysis...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29686722/energy-restriction-exercise-and-atorvastatin-treatment-improve-endothelial-dysfunction-and-inhibit-mirna-155-in-the-erectile-tissue-of-the-aged-rat
#8
B Rocha, A R Rodrigues, I Tomada, M J Martins, J T Guimarães, A M Gouveia, H Almeida, D Neves
Background: Endothelial dysfunction underlies cardiovascular disease that frequently affects aged individuals. Characterized by local decrease in nitric oxide, it results from down-regulation of endothelial nitric oxide synthase (eNOS) expression/activity. Aiming to elucidate the molecular mechanisms involved in age-related endothelial dysfunction and to unveil potential therapeutic targets, we tested how diet pattern, exercise and atorvastatin modulate the expression of eNOS, inducible NOS (iNOS), endothelin-1, sirtuins (SIRT) and microRNA-155 in the erectile tissue of high-fat fed aged rats...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29681992/association-between-the-ppp1r3b-polymorphisms-and-serum-lipid-traits-the-risk-of-coronary-artery-disease-and-ischemic-stroke-in-a-southern-chinese-han-population
#9
Wei-Jun Li, Rui-Xing Yin, Jian-Hua Huang, Yuan Bin, Wu-Xian Chen, Xiao-Li Cao
Background: Little is known about the association of the protein phosphatase 1 regulatory subunit 3B gene ( PPP1R3B ) single nucleotide polymorphisms (SNPs) and serum lipid levels, the risk of coronary artery disease (CAD) and ischemic stroke (IS) in the Chinese populations. This study detected such association in a Southern Chinese Han population. Methods: Genotypes of 4 novel PPP1R3B SNPs (rs12785, rs330910, rs330915 and rs9949) in 1704 Han Chinese (CAD, 556; IS, 531 and control, 617) were determined by the Snapshot technology...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29681991/the-relationship-between-mnsod-val16ala-gene-polymorphism-and-the-level-of-serum-total-antioxidant-capacity-with-the-risk-of-chronic-kidney-disease-in-type-2-diabetic-patients-a-nested-case-control-study-in-the-tehran-lipid-glucose-study
#10
Mehrnaz Abbasi, Maryam S Daneshpour, Mehdi Hedayati, Azadeh Mottaghi, Katayoun Pourvali, Fereidoun Azizi
Background: Several studies have shown significant associations between manganese superoxide dismutase (MnSOD) Val16Ala polymorphism and diabetic complications, but this association has not been explored in relation with chronic kidney disease (CKD) in Type 2 diabetes mellitus (T2DM) patients. Total antioxidant capacity (TAC) level changes in diabetic condition and may play important role in onset or progression of the disease and its complications. The present study investigated the association of MnSOD Val16Ala polymorphism and serum TAC with the risk of CKD in T2DM patients...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29651299/a-leukocyte-activation-test-identifies-food-items-which-induce-release-of-dna-by-innate-immune-peripheral-blood-leucocytes
#11
Irma Garcia-Martinez, Theresa R Weiss, Muhammad N Yousaf, Ather Ali, Wajahat Z Mehal
Background: Leukocyte activation (LA) testing identifies food items that induce a patient specific cellular response in the immune system, and has recently been shown in a randomized double blinded prospective study to reduce symptoms in patients with irritable bowel syndrome (IBS). We hypothesized that test reactivity to particular food items, and the systemic immune response initiated by these food items, is due to the release of cellular DNA from blood immune cells. Methods: We tested this by quantifying total DNA concentration in the cellular supernatant of immune cells exposed to positive and negative foods from 20 healthy volunteers...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29643928/effect-of-low-energy-diet-for-eight-weeks-to-adults-with-overweight-or-obesity-on-folate-retinol-vitamin-b-12-d-and-e-status-and-the-degree-of-inflammation-a-post-hoc-analysis-of-a-randomized-intervention-trial
#12
Nina Rica Wium Geiker, Mette Veller, Louise Kjoelbaek, Jette Jakobsen, Christian Ritz, Anne Raben, Arne Astrup, Janne Kunchel Lorenzen, Lesli H Larsen, Susanne Bügel
Background: Obesity is associated with vitamin insufficiency and low grade inflammation. The purpose of this study was to investigate the effect of weight loss on folate, retinol, vitamin B12 , D and E status and the degree of inflammation. Methods: Out of 110, 85 individuals (75% women) aged 39 ± 11 years with a mean ± SD BMI of 33 ± 4 kg/m2 , completed an eight-week low energy diet (LED). Serum concentration of folate, retinol, B12 , D and E and C-reactive protein and homocysteine (Hcy) were measured at baseline and at end of the LED...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29611545/correction-to-the-common-use-of-improper-control-diets-in-diet-induced-metabolic-disease-research-confounds-data-interpretation-the-fiber-factor
#13
Michael A Pellizzon, Matthew R Ricci
[This corrects the article DOI: 10.1186/s12986-018-0243-5.].
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29569628/correction-to-current-therapies-in-alleviating-liver-disorders-and-cancers-with-a-special-focus-on-the-potential-of-vitamin-d
#14
Shahida Khan, Ashraf Ali, Sarah Khan, Ahmed Bakillah, Ghazi Damanhouri, Aziz Khan, Ahmad Makki, Ibtehal AlAnsari, Naheed Banu
[This corrects the article DOI: 10.1186/s12986-018-0251-5.].
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29568317/rapeseed-oil-fortified-with-micronutrients-can-reduce-glucose-intolerance-during-a-high-fat-challenge-in-rats
#15
Frederic Capel, Alain Geloen, Carole Vaysse, Gaelle Pineau, Luc Demaison, Jean-Michel Chardigny, Marie-Caroline Michalski, Corinne Malpuech-Brugère
Background: Better choices of dietary lipid sources and substitution of refined by fortified oils could reduce the intake of saturated fatty acids (FA) and increase the intake of omega 3 FA concomitantly to healthy bioactive compounds. Methods: The development of obesity and metabolic disturbances was explored in rats fed during 11 weeks with a high fat diet (HFD) in which the amount of saturated and polyunsaturated FA was respectively reduced and increased, using rapeseed oil as lipid source...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29507597/a-low-protein-diet-exerts-a-beneficial-effect-on-diabetic-status-and-prevents-diabetic-nephropathy-in-wistar-fatty-rats-an-animal-model-of-type-2-diabetes-and-obesity
#16
Munehiro Kitada, Yoshio Ogura, Taeko Suzuki, Itaru Monno, Keizo Kanasaki, Ai Watanabe, Daisuke Koya
Background: The objective of this study is to investigate the effects of a low-protein diet (LPD) starting from a young age on diabetic status and renal injury in a rat model of type 2 diabetes and obesity. Methods: Diabetic male Wistar fatty ( fa/fa ) rats (WFRs) were fed a standard diet (23.84% protein) or an LPD (5.77% protein) for 24 weeks beginning at 6 weeks of age. We investigated the effects of the LPD on total body weight (BW); fat weight (FW); lower-limb muscle weight (MW); several measures of diabetic status, including fasting/random glucose levels, HOMA-IR and the IPITT; and renal injuries, including renal hypertrophy, albuminuria and histological changes...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29492096/total-antioxidant-capacity-of-the-diet-modulates-the-association-between-habitual-nitrate-intake-and-cardiovascular-events-a-longitudinal-follow-up-in-tehran-lipid-and-glucose-study
#17
Zahra Bahadoran, Mattias Carlström, Asghar Ghasemi, Parvin Mirmiran, Fereidoun Azizi, Farzad Hadaegh
Background: Considering the lack of data on the association between habitual dietary intakes of nitrate (NO3 - ) and nitrite (NO2 - ) and cardiovascular events, we assessed possible effects of dietary NO3 - and NO2 - , in the context of total antioxidant capacity (TAC) of the diet, with the risk of cardiovascular (CVD) outcomes. Methods: Adult men and women without CVD ( n  = 2369) were recruited from the Tehran Lipid and Glucose Study and were followed for a mean of 6...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29467800/resting-metabolic-rate-of-obese-patients-under-very-low-calorie-ketogenic-diet
#18
Diego Gomez-Arbelaez, Ana B Crujeiras, Ana I Castro, Miguel A Martinez-Olmos, Ana Canton, Lucia Ordoñez-Mayan, Ignacio Sajoux, Cristobal Galban, Diego Bellido, Felipe F Casanueva
Background: The resting metabolic rate (RMR) decrease, observed after an obesity reduction therapy is a determinant of a short-time weight regain. Thus, the objective of this study was to evaluate changes in RMR, and the associated hormonal alterations in obese patients with a very low-calorie ketogenic (VLCK)-diet induced severe body weight (BW) loss. Method: From 20 obese patients who lost 20.2 kg of BW after a 4-months VLCK-diet, blood samples and body composition analysis, determined by DXA and MF-Bioimpedance, and RMR by indirect calorimetry, were obtained on four subsequent visits: visit C-1, basal, initial fat mass (FM) and free fat mass (FFM); visit C-2, - 7...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29467799/exposure-to-maternal-cafeteria-diets-during-the-suckling-period-has-greater-effects-on-fat-deposition-and-sterol-regulatory-element-binding-protein-1c-srebp-1c-gene-expression-in-rodent-offspring-compared-to-exposure-before-birth
#19
M A Vithayathil, J R Gugusheff, Z Y Ong, S C Langley-Evans, R A Gibson, B S Muhlhausler
Background: While the adverse metabolic effects of exposure to obesogenic diets during both the prenatal and early postnatal period are well established, the relative impact of exposure during these separate developmental windows remains unclear. This study aimed to assess the relative contribution of exposure to a maternal cafeteria diet during pregnancy and lactation on body weight, fat mass and expression of lipogenic and adipokine genes in the offspring. Methods: Wistar rats were fed either a control chow (Control, n  = 14) or obesogenic cafeteria diet (CAF, n  = 12) during pregnancy and lactation...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29456587/dietary-diversity-and-associated-factors-among-children-of-orthodox-christian-mothers-caregivers-during-the-fasting-season-in-dejen-district-north-west-ethiopia
#20
Gemechu Kumera, Endalkachew Tsedal, Mulatu Ayana
Background: Proper feeding practices during early childhood is fundamental for optimal child growth and development. However, scientific evidences on the determinants of dietary diversity are scanty. Particularly, the impact of fasting on children`s dietary diversity is not explored in Ethiopia. The aim of this study was to assess dietary diversity and associated factors among children aged 6-23 months, whose mothers/care-givers were Orthodox Christians during the fasting season (Lent), in Dejen District, North West Ethiopia, 2016...
2018: Nutrition & Metabolism
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