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Nutrition & Metabolism

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https://www.readbyqxmd.com/read/28101124/reduced-up-regulation-of-the-nitric-oxide-pathway-and-impaired-endothelial-and-smooth-muscle-functions-in-the-female-type-2-diabetic-goto-kakizaki-rat-heart
#1
Martine Desrois, Carole Lan, Jamileh Movassat, Monique Bernard
BACKGROUND: Type 2 diabetes is associated with greater relative risk of cardiovascular diseases in women than in men, which is not well understood. Consequently, we have investigated if male and female displayed differences in cardiac function, energy metabolism, and endothelial function which could contribute to increased cardiovascular complications in type 2 diabetic female. METHODS: Male and female Control and type 2 diabetic Goto-Kakizaki (GK) isolated rat hearts were perfused during 28 min with a physiological buffer before freeze-clamping for biochemical assays...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28101123/regulatory-landscape-of-age-rage-oxidative-stress-axis-and-its-modulation-by-ppar%C3%AE-activation-in-high-fructose-diet-induced-metabolic-syndrome
#2
Luca Cannizzaro, Giuseppe Rossoni, Federica Savi, Alessandra Altomare, Cristina Marinello, Thammakorn Saethang, Marina Carini, D Michael Payne, Trairak Pisitkun, Giancarlo Aldini, Asada Leelahavanichkul
BACKGROUND: The AGE-RAGE-oxidative stress (AROS) axis is involved in the onset and progression of metabolic syndrome induced by a high-fructose diet (HFD). PPARγ activation is known to modulate metabolic syndrome; however a systems-level investigation looking at the protective effects of PPARγ activation as related to the AROS axis has not been performed. The aim of this work is to simultaneously characterize multiple molecular parameters within the AROS axis, using samples taken from different body fluids and tissues of a rat model of HFD-induced metabolic syndrome, in the presence or absence of a PPARγ agonist, Rosiglitazone (RGZ)...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28096887/thylakoids-reduce-body-fat-and-fat-cell-size-by-binding-to-dietary-fat-making-it-less-available-for-absorption-in-high-fat-fed-mice
#3
Karin G Stenkula, Eva-Lena Stenblom, Caroline Montelius, Emil Egecioglu, Charlotte Erlanson-Albertsson
BACKGROUND: Dietary thylakoids derived from spinach have beneficial effects on body fat accumulation and blood lipids as demonstrated in humans and rodents. Important mechanisms established include delayed fat digestion in the intestine, without causing steatorrhea, and increased fatty acid oxidation in intestinal cells. The objective of our study was to elucidate if increased fecal fat excretion is an important mechanism to normalize adipose tissue metabolism during high-fat feeding in mice supplemented with thylakoids...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28070205/plasticity-of-adipose-tissue-in-response-to-fasting-and-refeeding-in-male-mice
#4
Hao-Neng Tang, Chen-Yi Tang, Xiao-Fei Man, Shu-Wen Tan, Yue Guo, Jun Tang, Ci-La Zhou, Hou-De Zhou
BACKGROUND: Fasting is the most widely prescribed and self-imposed strategy for treating excessive weight gain and obesity, and has been shown to exert a number of beneficial effects. The aim of the present study was to determine the exact role of fasting and subsequent refeeding on fat distribution in mice. METHODS: C57/BL6 mice fasted for 24 to 72 h and were then subjected to refeeding for 72 h. At 24, 48 and 72 h of fasting, and 12, 24, 48 and 72 h of refeeding, the mice were sacrificed, and serum and various adipose tissues were collected...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28070204/evaluation-of-lactobacillus-coryniformis-cect5711-strain-as-a-coadjuvant-in-a-vaccination-process-a-randomised-clinical-trial-in-healthy-adults
#5
Noemí Redondo, Esther Nova, Alina Gheorghe, Ligia Esperanza Díaz, Aurora Hernández, Ascensión Marcos
BACKGROUND: Although the effects of probiotics on the immune system have been extensively evaluated under disease states, their role in healthy situations remains unclear, since changes are hardly expected under immunological homeostasis. EFSA indicates that vaccination protocols could be used to evaluate the potential role of probiotics to improve the immune response against antigen challenges. The aim of the study was to evaluate the effect of Lactobacillus coryniformis CECT5711 (Lc) on the specific immunity of healthy volunteers undergoing vaccination with Hepatitis A virus (HAV)...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28053645/do-metabolic-syndrome-and-its-components-have-an-impact-on-bone-mineral-density-in-adolescents
#6
REVIEW
Valéria Nóbrega da Silva, Luciana Nunes Mosca Fiorelli, Carla Cristiane da Silva, Cilmery Suemi Kurokawa, Tamara Beres Lederer Goldberg
In recent years, there has been growing concern about the occurrence of metabolic syndrome (MetS) at an early age and its effects on bone mass in adolescents. Adolescence is considered a critical period for bone mass gain. Impaired bone acquisition during this phase can lead to "suboptimal" peak bone mass and increase the risk of osteopenia/osteoporosis and fractures in old age. The objective of this review was to perform a critical analysis of articles that specifically focus on this age group, evaluating the influence of MetS and its components on bone mineral density in adolescents...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27990172/nutritional-modulation-of-endogenous-glucagon-like-peptide-1-secretion-a-review
#7
REVIEW
Alexandra M Bodnaruc, Denis Prud'homme, Rosanne Blanchet, Isabelle Giroux
BACKGROUND: The positive influences of glucagon-like peptide-1 (GLP-1) on blood glucose homeostasis, appetite sensations, and food intake provide a strong rationale for its therapeutic potential in the nutritional management of obesity and type 2 diabetes. AIM: To summarize GLP-1 physiology and the nutritional modulation of its secretion in the context of obesity and type 2 diabetes management. FINDINGS: GLP-1 is mainly synthesized and secreted by enteroendocrine L-cells of the gastrointestinal tract...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27980600/rose-hip-supplementation-increases-energy-expenditure-and-induces-browning-of-white-adipose-tissue
#8
Michele Cavalera, Ulrika Axling, Karin Berger, Cecilia Holm
BACKGROUND: Overweight and obesity are widespread chronic disorders defined as excessive fat accumulation, and are major risk factors for several chronic diseases including type 2 diabetes, coronary heart disease, high blood pressure and fatty liver. Changes in lifestyle such as increased physical activity and a healthy diet can be crucial tools for treating obesity. Intake of rose hip, the fruit of several plants belonging to the Rosaceae family, has been shown to reduce body fat mass and prevent body weight gain...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27980599/effects-of-controlled-doses-of-oxyelite-pro-on-physical-performance-in-rats
#9
Paulo Vinicios Camuzi Zovico, Victor Magalhães Curty, Marcos André Soares Leal, Eduardo Frizzera Meira, Daniel Ventura Dias, Lívia Carla de Melo Rodrigues, Silvana Dos Santos Meyrelles, Edilamar Menezes De Oliveira, Paula Frizera Vassallo, Valério Garrone Barauna
BACKGROUND: OxyElite Pro (OEP) is a dietary supplement to increase metabolism which contains as key stimulant the ingredient 1,3-dimethylamylamine (DMAA). Serious adverse effects have been reported after OEP consumption however, these effects are related to poisoning or overdose. To our knowledge, no one studied the effects of OEP at controlled doses. Thus, the aim of this study was to evaluate acute and chronic OEP affects, at controlled doses in Wistar rats, on physical performance, metabolic parameters, liver injury markers and oxidative stress markers and mitochondrial biogenesis in skeletal muscle...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27980598/phytochemicals-as-novel-agents-for-the-induction-of-browning-in-white-adipose-tissue
#10
REVIEW
Yusra Azhar, Ashish Parmar, Colette N Miller, Janaiya S Samuels, Srujana Rayalam
Obesity and its associated metabolic syndrome continue to be a health epidemic in westernized societies and is catching up in the developing world. Despite such increases, little headway has been made to reverse adverse weight gain in the global population. Few medical options exist for the treatment of obesity which points to the necessity for exploration of anti-obesity therapies including pharmaceutical and nutraceutical compounds. Defects in brown adipose tissue, a major energy dissipating organ, has been identified in the obese and is hypothesized to contribute to the overall metabolic deficit observed in obesity...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27980597/alpha-mangostin-from-mangosteen-garcinia-mangostana-linn-pericarp-extract-reduces-high-fat-diet-induced-hepatic-steatosis-in-rats-by-regulating-mitochondria-function-and-apoptosis
#11
Shin-Yu Tsai, Pei-Chin Chung, Eddy E Owaga, I-Jong Tsai, Pei-Yuan Wang, Jeng-I Tsai, Tien-Shun Yeh, Rong-Hong Hsieh
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is caused by multiple factors including hepatic oxidative stress, lipotoxicity, and mitochondrial dysfunction. Obesity is among the risk factors for NAFLD alongside type 2 diabetes mellitus and hyperlipidemia. α- mangostin (α-MG) extracts from the pericarps of mangosteen (Garcinia mangostana Linn.) may regulate high fat diet-induced hepatic steatosis; however the underlying mechanisms remain unknown. The aim of this study was to investigate the regulatory effect of α-MG on high fat diet-induced hepatic steatosis and the underlying mechanisms related to mitochondrial functionality and apoptosis in vivo and in vitro...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27933093/long-term-consumption-of-an-obesogenic-high-fat-diet-prior-to-ischemia-reperfusion-mediates-cardioprotection-via-epac1-dependent-signaling
#12
F Edland, A Wergeland, R Kopperud, K S Åsrud, E A Hoivik, S L Witsø, R Æsøy, L Madsen, K Kristiansen, M Bakke, S O Døskeland, A K Jonassen
BACKGROUND: Obesity is still considered a risk factor for cardiovascular disease, although more recent knowledge also suggests obesity to be associated with reduced morbidity and mortality - the "obesity paradox". This study explores if long-term feeding of an obesogenic high fat diet renders the myocardium less susceptible to ischemic-reperfusion induced injury via Epac-dependent signaling. METHODS: Wild type (wt), Epac1 (Epac1(-/-)) and Epac2 (Epac2(-/-)) deficient mice were fed a high fat (HFD) or normal chow diet (ND) for 33 ± 1 weeks...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27933092/effects-of-purified-anthocyanin-supplementation-on-platelet-chemokines-in-hypocholesterolemic-individuals-a-randomized-controlled-trial
#13
Xiandan Zhang, Yanna Zhu, Fenglin Song, Yanling Yao, Fuli Ya, Dan Li, Wenhua Ling, Yan Yang
BACKGROUND: It is becoming increasingly evident that platelet chemokines are involved in distinct aspects of atherosclerosis. The aim of this study was to examine the effects of long-term supplementation with purified anthocyanins on platelet chemokines in hypercholesterolemic individuals and to identify correlations of decreased platelet chemokine levels with serum lipid and inflammatory marker levels. METHODS: A total of 146 hypercholesterolemic individuals were recruited and treated with 320 mg of purified anthocyanins (n = 73) or a placebo (n = 73) daily for 24 weeks in this randomized, double-blind, placebo-controlled trial...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27904645/predicting-resting-energy-expenditure-in-underweight-normal-weight-overweight-and-obese-adult-hospital-patients
#14
Hinke M Kruizenga, Geesje H Hofsteenge, Peter J M Weijs
BACKGROUND: When indirect calorimetry is not available, predictive equations are used to estimate resing energy expenditure (REE). There is no consensus about which equation to use in hospitalized patients. The objective of this study is to examine the validity of REE predictive equations for underweight, normal weight, overweight, and obese inpatients and outpatients by comparison with indirect calorimetry. METHODS: Equations were included when based on weight, height, age, and/or gender...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27895698/combinations-of-bio-active-dietary-constituents-affect-human-white-adipocyte-function-in-vitro
#15
Ines Warnke, Johan W E Jocken, Rotraut Schoop, Christine Toepfer, Regina Goralczyk, Joseph Schwager
BACKGROUND: Specific bio-active dietary compounds modulate numerous metabolic processes in adipose tissue (AT), including pre-adipocyte proliferation and differentiation. AT dysfunction, rather than an increased fat mass per se, is strongly associated with the development of insulin resistance and is characterized by impaired adipogenesis, hypertrophic adipocytes, inflammation, and impairments in substrate metabolism. A better understanding of mechanisms underlying AT dysfunction may provide new strategies for the treatment of obesity-associated metabolic diseases...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27891168/erratum-to-assessment-of-vitamin-d-status-in-a-group-of-egyptian-children-with-non-alcoholic-fatty-liver-disease-multicenter-study
#16
Amal Ahmed Mohamed, Maha Abdel Ghany, Gehan Lotfy Abdel Hakeem, Aya Mostafa, Rania Abdelmonem Khattab, Asmaa Mahmoud Abdalla, Laila El Morsi Abou El Fotoh, Abdel Azeem El Mazary, Madiha Abdalla Sayed, Ashraf Mohamed Abdel Fadil
[This corrects the article DOI: 10.1186/s12986-016-0112-z.].
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27891167/effect-on-body-weight-and-composition-in-overweight-obese-australian-adults-over-12%C3%A2-months-consumption-of-two-different-types-of-fibre-supplementation-in-a-randomized-trial
#17
Sebely Pal, Suleen Ho, Roland J Gahler, Simon Wood
BACKGROUND/OBJECTIVES: Higher fibre intakes are associated with risk reduction for chronic diseases. However, many people find difficulty in consuming sufficient fibre through their diet. Supplements may be an effective alternative. We aimed to investigate the effects of PolyGlycopleX® (PGX®), a proprietary polysaccharide complex and a proprietary Psyllium product (PgxSyl™) (PSY) on diet, body weight and composition in overweight and obese individuals. SUBJECTS/METHODS: This was a double-blind 52 weeks study with 159 people randomized to 3 groups: control (rice flour); PGX (PGX) and proprietary psyllium (PSY)...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27891166/relation-of-24-hour-urinary-caffeine-and-caffeine-metabolite-excretions-with-self-reported-consumption-of-coffee-and-other-caffeinated-beverages-in-the-general-population
#18
Dusan Petrovic, Sandrine Estoppey Younes, Menno Pruijm, Belén Ponte, Daniel Ackermann, Georg Ehret, Nicolas Ansermot, Markus Mohaupt, Fred Paccaud, Bruno Vogt, Antoinette Pechère-Bertschi, Pierre-Yves Martin, Michel Burnier, Chin B Eap, Murielle Bochud, Idris Guessous
BACKGROUND: Caffeine intake is generally estimated by self-reported consumption, but it remains unclear how well self-report associates with metabolite urinary excretion. We investigated the associations of self-reported consumption of caffeinated drinks with urinary excretion of caffeine and its major metabolites in an adult population. METHODS: We used data from the population-based Swiss Kidney Project on Genes in Hypertension (SKIPOGH) study. Consumption of caffeinated coffee, decaffeinated coffee and other caffeinated beverages was assessed by self-administered questionnaire...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27891165/postprandial-lipemic-and-inflammatory-responses-to-high-fat-meals-a-review-of-the-roles-of-acute-and-chronic-exercise
#19
REVIEW
Colby S Teeman, Stephanie P Kurti, Brooke J Cull, Sam R Emerson, Mark D Haub, Sara K Rosenkranz
Postprandial lipemia is an independent risk factor for development of cardiovascular disease. Postprandial inflammation following the prolonged elevation of triglycerides occurring subsequent to ingestion of high-fat meals, provides a likely explanation for increased disease risk. Substantial evidence has shown that acute exercise is an effective modality for attenuation of postprandial lipemia following a high-fat meal. However, much of the evidence pertaining to exercise intensity, duration, and overall energy expenditure for reducing postprandial lipemia is inconsistent...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27891164/a-low-carbohydrate-high-fat-diet-decreases-lean-mass-and-impairs-cardiac-function-in-pair-fed-female-c57bl-6j-mice
#20
Jessica Nilsson, Madelene Ericsson, Masoumeh Motamedi Joibari, Fredrick Anderson, Leif Carlsson, Stefan K Nilsson, Anna Sjödin, Jonas Burén
BACKGROUND: Excess body fat is a major health issue and a risk factor for the development of numerous chronic diseases. Low-carbohydrate diets like the Atkins Diet are popular for rapid weight loss, but the long-term consequences remain the subject of debate. The Scandinavian low-carbohydrate high-fat (LCHF) diet, which has been popular in Scandinavian countries for about a decade, has very low carbohydrate content (~5 E %) but is rich in fat and includes a high proportion of saturated fatty acids...
2016: Nutrition & Metabolism
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