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CytoJournal

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https://www.readbyqxmd.com/read/28331530/kras-detection-on-archival-cytological-smears-by-the-novel-fully-automated-polymerase-chain-reaction-based-idylla-mutation-test
#1
Caterina De Luca, Elena Vigliar, Melania d'Anna, Pasquale Pisapia, Claudio Bellevicine, Umberto Malapelle, Giancarlo Troncone
BACKGROUND: Molecular techniques are relevant to modern cytopathology, but their implementation is difficult without molecular expertise and infrastructure. The assessment of KRAS mutational status on cytological preparations may be useful either to refine uncertain diagnoses on pancreatic aspirates or to yield predictive information to plan targeted treatment of metastatic colorectal cancer (mCRC). The novel test Idylla™ enables fully automated KRAS genotyping in approximately 2 h, even in less experienced hands...
2017: CytoJournal
https://www.readbyqxmd.com/read/28331529/detection-of-braf-mutation-in-the-cytocentrifugation-supernatant-fluid-from-fine-needle-aspiration-of-thyroid-lesions-may-enhance-the-diagnostic-yield
#2
Ashley E Brown, Khin Sandar Lim, George Corpus, Martha T Hustek, Tien Anh N Tran, Chung-Che Chang
OBJECTIVE: BRAF mutations using cellular DNA from fine-needle aspiration (FNA) specimens are commonly used to support the diagnosis of papillary thyroid carcinoma (PTC). The goal of this study was to preliminarily evaluate the diagnostic utility of detecting BRAF mutations in the routinely discarded FNA specimen supernatant fluid. MATERIALS AND METHODS: Seventy-eight FNAs of thyroid lesions were evaluated for BRAF mutations using both cellular and supernatant DNA...
2017: CytoJournal
https://www.readbyqxmd.com/read/28331528/thyroid-fine-needle-aspiration-of-an-immunocompromised-patient-cytomorphological-clues
#3
Longwen Chen, Nirvikar Dahiya, Matthew A Zarka
No abstract text is available yet for this article.
2017: CytoJournal
https://www.readbyqxmd.com/read/28217141/primary-orbital-mantle-cell-lymphoma-flow-cytometric-immunophenotyping-as-an-adjunct-to-fine-needle-aspiration-cytology-for-diagnosis
#4
Sangeeta Verma, Nalini Gupta, Satyawati Mohindra, Manupdesh Singh Sachdeva, Arvind Rajwanshi
No abstract text is available yet for this article.
2017: CytoJournal
https://www.readbyqxmd.com/read/28217140/evaluation-of-polymerase-chain-reaction-in-space-occupying-lesions-of-liver-reported-as-granulomatous-inflammation-tuberculosis-on-fine-needle-aspiration-cytology
#5
Kusum Sharma, Nalini Gupta, Kapil Goyal, Ajay Kumar Duseja, Aman Sharma, Arvind Rajwanshi
BACKGROUND: Tubercular involvement of the liver is uncommon, but is a serious consideration in differential diagnosis of granulomatous conditions, especially in endemic regions like India. OBJECTIVE: To assess the role of polymerase chain reaction (PCR) done on archival cytological material in diagnosing tuberculosis (TB) in cases reported as granulomatous inflammation/TB in liver lesions. MATERIALS AND METHODS: This was a retrospective study including a total of 17 cases of liver space-occupying lesions (SOLs) reported as granulomatous inflammation (n = 12) and TB (n = 5)...
2017: CytoJournal
https://www.readbyqxmd.com/read/28105065/an-unexpected-diagnosis-of-ectopic-liver-diagnosed-by-fine-needle-aspiration
#6
Gonzalo Barazza, Douglas G Adler, Rachel E Factor
The differential diagnosis of perigastric masses is broad, ranging from benign to malignant entities. Among the benign entities, accessory liver lobes and ectopic liver are unusual and often incidentally discovered. Here, we report a patient with malignant melanoma who was clinically suspected to have a perigastric metastasis or a gastrointestinal stromal tumor but was ultimately diagnosed by fine needle aspiration (FNA) to have benign ectopic liver. A 47-year-old male was diagnosed with malignant melanoma of the scalp in May 2015 at a tertiary care hospital...
2016: CytoJournal
https://www.readbyqxmd.com/read/28105064/detection-of-in-situ-and-invasive-endocervical-adenocarcinoma-on-thinprep-pap-test-morphologic-analysis-of-false-negative-cases
#7
Michael Chaump, Edyta C Pirog, Vinicius J A Panico, Alexandre Buckley D Meritens, Kevin Holcomb, Rana Hoda
BACKGROUND: The goal of this study was to calculate the sensitivity and false negative (FN) rate of ThinPrep Pap Test (TPPT) and carefully analyze missed cases for educational purposes. MATERIALS AND METHODS: Patients with histologically proven adenocarcinoma in-situ (AIS) or invasive endocervical adenocarcinoma (EAC) over a 17-year-period (1998-2015) were identified. The TPPT immediately preceding the histological diagnosis of AIS/ECA was designated as index Pap (IP)...
2016: CytoJournal
https://www.readbyqxmd.com/read/27994636/the-effect-of-the-small-amount-of-formaldehyde-in-the-surepath-liquid-when-establishing-protocols-for-immunocytochemistry
#8
Ellen Cathrine Bjønness-Jacobsen, Anne Kristine Kallevåg Eriksen, Vidar Nyløkken Hagen, Kirsten Margrethe Østbye, Anna Wittersø, Mette Kristin Pedersen, Torill Sauer
BACKGROUND: SurePath(®) is an ethanol-based liquid fixative. In addition to ethanol, it also contains a small amount of formaldehyde (<0.2%). The aim of this study was to investigate the immunoreactivity of cells stored for different lengths of time in the SurePath liquid. MATERIALS AND METHODS: Rest material from one malignant and three benign effusions were fixed in SurePath for 1-12 days. Cytospins were incubated with cytokeratin 7 antibody (AB) to evaluate the staining intensity of carcinoma cells and benign, reactive mesothelial cells...
2016: CytoJournal
https://www.readbyqxmd.com/read/27994635/diagnostic-utility-of-double-immunostaining-of-a-urine-cytology-preparation-for-cytokeratin-20-p53-expression-in-a-young-woman-with-micropapillary-urothelial-carcinoma-of-the-renal-pelvis-presenting-as-an-unknown-primary-malignancy
#9
Hyun-Jung Kim, Lucky Sung, Jung-Yeon Kim, Kyeongmee Park
Atypical urine cytology (CYT) triggers a cystoscopic or another ancillary investigation that targets urothelial neoplasms. We report a case presenting as an unknown primary malignancy, which illustrated the diagnostic utility of direct double immunostaining for cytokeratin 20 (CK20)/p53 expression in a urine CYT specimen. A 42-year-old woman visited the emergency room for pain in her right lower abdominal quadrant. Computed tomography revealed postrenal obstructive hydronephrosis, and her urine CYT showed malignancy, type undetermined...
2016: CytoJournal
https://www.readbyqxmd.com/read/27761150/erratum-cytojournal-quiz-cases-publishing-open-access-pubmed-searchable-cytopathology-cases-with-educational-messages
#10
(no author information available yet)
[This corrects the article on p. 15 in vol. 13, PMID: 27563338.].
2016: CytoJournal
https://www.readbyqxmd.com/read/27761149/endoscopic-ultrasound-guided-fine-needle-aspiration-cytology-of-metastatic-renal-cell-carcinoma-to-the-pancreas-a-multi-center-experience
#11
Rahul Pannala, Karyn M Hallberg-Wallace, Amber L Smith, Aziza Nassar, Jun Zhang, Matthew Zarka, Jordan P Reynolds, Longwen Chen
INTRODUCTION: The increasing use of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) cytology to examine pancreatic neoplasms has led to an increase in the diagnosis of metastases to the pancreas. Renal cell carcinoma (RCC) is the most common metastasis to the pancreas. Our study examines 33 cases of metastatic RCC to the pancreas sampled by EUS-FNA from four large tertiary care hospitals. MATERIALS AND METHODS: We searched the cytopathology database for RCC metastatic to the pancreas diagnosed by EUS-FNA from January 2005 to January 2015...
2016: CytoJournal
https://www.readbyqxmd.com/read/27761148/oncocytic-variant-of-poorly-differentiated-thyroid-carcinoma-is-diagnosis-possible-by-fine-needle-aspiration
#12
Mine Onenerk, Sule Canberk, Pembegul Gunes, Murat Erkan, Gamze Z Kilicoglu
Poorly differentiated thyroid carcinoma (PDTC) is a very rare entity, and the diagnosis can be made on histopathology specimens. However, recognition of characteristic features of PDTC is significant on fine-needle aspirations (FNAs) to differentiate this entity from well-differentiated and anaplastic thyroid carcinomas. Here, we present an FNA case concordant with "oncocytic variant of PDTC" and discuss whether definitive diagnosis can be given on FNAs to assess the prognosis in clinically inoperable patients...
2016: CytoJournal
https://www.readbyqxmd.com/read/27729936/prognostic-markers-in-smear-preparations-for-pancreatic-endocrine-neoplasms-a-cytomorphologic-study-and-statistical-analysis-of-20-potential-prognostic-features
#13
Lester J Layfield, Robert L Schmidt, Jack Campbell, Magda Esebua
BACKGROUND: Papanicolaou Society of Cytopathology guidelines place low- and intermediate-grade pancreatic endocrine tumors into the "neoplastic, other" category whereas high-grade pancreatic endocrine tumors are placed in the "malignant" category. No attempt was made to stratify pancreatic endocrine tumors in the "neoplastic, other" category by likelihood for metastases. Histologically, pancreatic endocrine tumors are divided into well, intermediate, and poorly differentiated examples based on mitotic count and Ki-67 proliferation index (PI)...
2016: CytoJournal
https://www.readbyqxmd.com/read/27729935/a-case-of-s-100-negative-melanoma-a-diagnostic-pitfall-in-the-workup-of-a-poorly-differentiated-metastatic-tumor-of-unknown-origin
#14
Anna Biernacka, Konstantinos D Linos, Peter A DeLong, Arief A Suriawinata, Vijayalakshmi Padmanabhan, Xiaoying Liu
When confronted with a metastatic poorly differentiated tumor of unknown origin, the initial workup includes the standard panel of immunostains to rule out carcinoma, sarcoma, lymphoma, and the greatest mimicker in pathology - malignant melanoma. Although not specific, the S-100 protein is expressed in over 95% of malignant melanomas. Herein, we present a case of multiorgan metastatic malignancy with a dominant hilar and mediastinal mass in a current smoker; clinically, highly suggestive of widespread primary lung cancer...
2016: CytoJournal
https://www.readbyqxmd.com/read/27651822/stromal-tissue-as-an-adjunct-tool-in-the-diagnosis-of-follicular-thyroid-lesions-by-fine-needle-aspiration-biopsy
#15
Kien T Mai, Kevin Hogan
BACKGROUND: The stroma in fine-needle aspiration biopsy (FNAB) of thyroid lesions has not been well investigated. DESIGN: We studied 256 consecutive cases of thyroid FNAB prepared with traditional smear technique. The stroma was categorized: Type 1a consisted of long (more than 3 mm), broad bands composed of mesh containing collagen fibrils thickened by entrapped blood components and follicular cells. Type 1b consisted of dense strands/bands. Type 2 was similar to Type 1a but with shorter (<2 mm) and looser stromal strands...
2016: CytoJournal
https://www.readbyqxmd.com/read/27651821/diagnostic-relevance-of-cell-block-procedure-in-secondary-tumors-of-the-pancreas
#16
Antonio Ieni, Valeria Barresi, Giovanni Tuccari
No abstract text is available yet for this article.
2016: CytoJournal
https://www.readbyqxmd.com/read/27651820/fine-needle-aspiration-and-core-biopsy-in-the-diagnosis-of-breast-lesions-a-comparison-and-review-of-the-literature
#17
REVIEW
Suvradeep Mitra, Pranab Dey
In recent times, the diagnosis of breast lesions has mostly become dependent on core needle biopsies (CNBs) with a gradual reduction in the rate of performing fine-needle aspiration cytology (FNAC). Both the procedures have their pros and cons and outsmart each other taking into account different parameters. Both the methods are found to be fraught with loopholes, taking into account different performance indices, diagnostic accuracy and concordance, patient benefit, and cost-effectiveness. Unlike the popular belief of an absolute superiority of CNB over FNAC, the literature review does not reveal a very distinct demarcation in many aspects...
2016: CytoJournal
https://www.readbyqxmd.com/read/27563340/tuberculous-lymphadenitis-comparison-of-cytomorphology-ziehl-neelsen-staining-and-rapid-mycobacterial-culture-at-a-pediatric-superspecialty-hospital
#18
Sonam Mahana, Reena Tomar, Rawi Agrawal, Rushika Saksena, Vikas Manchanda, Ruchika Gupta
BACKGROUND: To evaluate and compare the role of Ziehl-Neelsen (ZN) staining and mycobacterial culture in diagnosis of tuberculous lymphadenitis. MATERIALS AND METHODS: A total of 56 fine needle aspirations (FNAs) from patients who were clinically suspected to have tuberculous lymphadenitis were included. Acid-fast Bacilli detection was attempted by ZN staining on smears as well as culture on Middlebrook 7H9 broth. Percentage positivity of both smears and culture was calculated...
2016: CytoJournal
https://www.readbyqxmd.com/read/27563339/fine-needle-aspiration-cytology-of-cervical-lymph-node-involvement-by-ovarian-serous-borderline-tumor
#19
Longwen Chen, Kristina A Butler, Debra A Bell
Serous borderline tumor (SBT) involving a cervical lymph node is extremely rare. In addition, fine needle aspiration (FNA) cytology of the involved cervical lymph node shares tremendous morphologic similarity with other low-grade papillary carcinomas. Thus, it can be easily misdiagnosed as metastatic carcinoma. A 42-year-old female had a history of bilateral SBT and postbilateral salpingo-oophorectomy. She presented with left cervical lymphadenopathy 6 months later. FNA cytology showed a low-grade papillary neoplasm with psammoma bodies...
2016: CytoJournal
https://www.readbyqxmd.com/read/27563338/cytojournal-quiz-cases-publishing-open-access-pubmed-searchable-cytopathology-cases-with-educational-messages
#20
Katherine G Akers, Vinod B Shidman
No abstract text is available yet for this article.
2016: CytoJournal
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