journal
MENU ▼
Read by QxMD icon Read
search

PLoS Medicine

journal
https://www.readbyqxmd.com/read/28817562/antimicrobial-resistance-the-complex-challenge-of-measurement-to-inform-policy-and-the-public
#1
Didier Wernli, Peter S Jørgensen, Stephan Harbarth, Scott P Carroll, Ramanan Laxminarayan, Nicolas Levrat, John-Arne Røttingen, Didier Pittet
Didier Wernli and colleagues discuss the role of monitoring in countering antimicrobial resistance.
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28809936/benefits-and-safety-of-gabapentinoids-in-chronic-low-back-pain-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
Harsha Shanthanna, Ian Gilron, Manikandan Rajarathinam, Rizq AlAmri, Sriganesh Kamath, Lehana Thabane, Philip J Devereaux, Mohit Bhandari
BACKGROUND AND OBJECTIVE: Chronic Low Back Pain (CLBP) is very common, with a lifetime prevalence between 51% and 80%. In majority, it is nonspecific in nature and multifactorial in etiology. Pregabalin (PG) and Gabapentin (GB) are gabapentinoids that have demonstrated benefit in neuropathic pain conditions. Despite no clear rationale, they are increasingly used for nonspecific CLBP. They necessitate prolonged use and are associated with adverse effects and increased cost. Recent guidelines from the National Health Service (NHS), England, expressed concerns on their off-label use, in addition to the risk of misuse...
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28809935/effectiveness-of-a-brief-behavioural-intervention-on-psychological-distress-among-women-with-a-history-of-gender-based-violence-in-urban-kenya-a-randomised-clinical-trial
#3
Richard A Bryant, Alison Schafer, Katie S Dawson, Dorothy Anjuri, Caroline Mulili, Lincoln Ndogoni, Phiona Koyiet, Marit Sijbrandij, Jeannette Ulate, Melissa Harper Shehadeh, Dusan Hadzi-Pavlovic, Mark van Ommeren
BACKGROUND: Gender-based violence (GBV) represents a major cause of psychological morbidity worldwide, and particularly in low- and middle-income countries (LMICs). Although there are effective treatments for common mental disorders associated with GBV, they typically require lengthy treatment programs that may limit scaling up in LMICs. The aim of this study was to test the effectiveness of a new 5-session behavioural treatment called Problem Management Plus (PM+) that lay community workers can be taught to deliver...
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28809929/pregnant-and-breastfeeding-women-a-priority-population-for-hiv-viral-load-monitoring
#4
Landon Myer, Shaffiq Essajee, Laura N Broyles, D Heather Watts, Maia Lesosky, Wafaa M El-Sadr, Elaine J Abrams
Landon Myer and colleagues discuss viral load monitoring for pregnant HIV-positive women and those breastfeeding; ART treatments can suppress viral load and are key to preventing transmission to the child.
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28809928/lay-worker-administered-behavioral-treatments-for-psychological-distress-in-resource-limited-settings-time-to-move-from-evidence-to-practice
#5
Alexander C Tsai
In this Perspective on the study by Bryant and colleagues, Alex Tsai discusses the evidence supporting lay worker-administered, behavioral interventions for women survivors of interpersonal violence.
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28809926/impact-of-fortified-versus-unfortified-lipid-based-supplements-on-morbidity-and-nutritional-status-a-randomised-double-blind-placebo-controlled-trial-in-ill-gambian-children
#6
Stefan A Unger, Saikou Drammeh, Jahid Hasan, Kabiru Ceesay, Edrisa Sinjanka, Sainey Beyai, Bakary Sonko, Bai Lamin Dondeh, Anthony J Fulford, Sophie E Moore, Andrew M Prentice
BACKGROUND: Multiple micronutrients (MMN) are commonly prescribed in pediatric primary healthcare in sub-Saharan Africa to improve nutritional status and appetite without evidence for their effectiveness or international clinical guidelines. Community-wide MMN supplementation has shown limited and heterogeneous impact on growth and morbidity. Short-term ready-to-use therapeutic foods in acutely sick children in a hospital setting also had limited efficacy regarding subsequent growth. The effectiveness of MMN in improving morbidity or growth in sick children presenting for primary care has not been assessed...
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28792957/assessing-the-impact-of-healthcare-research-a-systematic-review-of-methodological-frameworks
#7
Samantha Cruz Rivera, Derek G Kyte, Olalekan Lee Aiyegbusi, Thomas J Keeley, Melanie J Calvert
BACKGROUND: Increasingly, researchers need to demonstrate the impact of their research to their sponsors, funders, and fellow academics. However, the most appropriate way of measuring the impact of healthcare research is subject to debate. We aimed to identify the existing methodological frameworks used to measure healthcare research impact and to summarise the common themes and metrics in an impact matrix. METHODS AND FINDINGS: Two independent investigators systematically searched the Medical Literature Analysis and Retrieval System Online (MEDLINE), the Excerpta Medica Database (EMBASE), the Cumulative Index to Nursing and Allied Health Literature (CINAHL+), the Health Management Information Consortium, and the Journal of Research Evaluation from inception until May 2017 for publications that presented a methodological framework for research impact...
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28792502/harmonization-of-community-health-worker-programs-for-hiv-a-four-country-qualitative-study-in-southern-africa
#8
Jan-Walter De Neve, Henri Garrison-Desany, Kathryn G Andrews, Nour Sharara, Chantelle Boudreaux, Roopan Gill, Pascal Geldsetzer, Maria Vaikath, Till Bärnighausen, Thomas J Bossert
BACKGROUND: Community health worker (CHW) programs are believed to be poorly coordinated, poorly integrated into national health systems, and lacking long-term support. Duplication of services, fragmentation, and resource limitations may have impeded the potential impact of CHWs for achieving HIV goals. This study assesses mediators of a more harmonized approach to implementing large-scale CHW programs for HIV in the context of complex health systems and multiple donors. METHODS AND FINDINGS: We undertook four country case studies in Lesotho, Mozambique, South Africa, and Swaziland between August 2015 and May 2016...
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28792500/malaria-malnutrition-and-birthweight-a-meta-analysis-using-individual-participant-data
#9
Jordan E Cates, Holger W Unger, Valerie Briand, Nadine Fievet, Innocent Valea, Halidou Tinto, Umberto D'Alessandro, Sarah H Landis, Seth Adu-Afarwuah, Kathryn G Dewey, Feiko O Ter Kuile, Meghna Desai, Stephanie Dellicour, Peter Ouma, Julie Gutman, Martina Oneko, Laurence Slutsker, Dianne J Terlouw, Simon Kariuki, John Ayisi, Mwayiwawo Madanitsa, Victor Mwapasa, Per Ashorn, Kenneth Maleta, Ivo Mueller, Danielle Stanisic, Christentze Schmiegelow, John P A Lusingu, Anna Maria van Eijk, Melissa Bauserman, Linda Adair, Stephen R Cole, Daniel Westreich, Steven Meshnick, Stephen Rogerson
BACKGROUND: Four studies previously indicated that the effect of malaria infection during pregnancy on the risk of low birthweight (LBW; <2,500 g) may depend upon maternal nutritional status. We investigated this dependence further using a large, diverse study population. METHODS AND FINDINGS: We evaluated the interaction between maternal malaria infection and maternal anthropometric status on the risk of LBW using pooled data from 14,633 pregnancies from 13 studies (6 cohort studies and 7 randomized controlled trials) conducted in Africa and the Western Pacific from 1996-2015...
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28771476/evaluation-of-novel-computerized-tomography-scoring-systems-in-human-traumatic-brain-injury-an-observational-multicenter-study
#10
MULTICENTER STUDY
Eric Peter Thelin, David W Nelson, Juho Vehviläinen, Harriet Nyström, Riku Kivisaari, Jari Siironen, Mikael Svensson, Markus B Skrifvars, Bo-Michael Bellander, Rahul Raj
BACKGROUND: Traumatic brain injury (TBI) is a major contributor to morbidity and mortality. Computerized tomography (CT) scanning of the brain is essential for diagnostic screening of intracranial injuries in need of neurosurgical intervention, but may also provide information concerning patient prognosis and enable baseline risk stratification in clinical trials. Novel CT scoring systems have been developed to improve current prognostic models, including the Stockholm and Helsinki CT scores, but so far have not been extensively validated...
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28763449/identification-of-factors-associated-with-stillbirth-in-the-indian-state-of-bihar-using-verbal-autopsy-a-population-based-study
#11
Rakhi Dandona, G Anil Kumar, Amit Kumar, Priyanka Singh, Sibin George, Mohammad Akbar, Lalit Dandona
BACKGROUND: India was estimated to have the largest numbers of stillbirths globally in 2015, and the Indian government has adopted a target of <10 stillbirths per 1,000 births by 2030 through the India Newborn Action Plan (INAP). The objective of this study was to use verbal autopsy interviews to examine factors associated with stillbirth in the Indian state of Bihar and make recommendations for the INAP to better inform the setting of priorities and actions to reduce stillbirths. METHODS AND FINDINGS: Verbal autopsy interviews were conducted for deaths including stillbirths that occurred from January 2011 to March 2014 in a sample of 109,689 households (87...
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28763446/gestational-diabetes-mellitus-and-interpregnancy-weight-change-a-population-based-cohort-study
#12
L M Sorbye, R Skjaerven, K Klungsoyr, N H Morken
BACKGROUND: Being overweight is an important risk factor for Gestational Diabetes Mellitus (GDM), but the underlying mechanisms are not understood. Weight change between pregnancies has been suggested to be an independent mechanism behind GDM. We assessed the risk for GDM in second pregnancy by change in Body Mass Index (BMI) from first to second pregnancy and whether BMI and gestational weight gain modified the risk. METHODS AND FINDINGS: In this observational cohort, we included 24,198 mothers and their 2 first pregnancies in data from the Medical Birth Registry of Norway (2006-2014)...
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28763444/childhood-adiposity-and-risk-of-type-1-diabetes-a-mendelian-randomization-study
#13
J C Censin, Christoph Nowak, Nicholas Cooper, Peter Bergsten, John A Todd, Tove Fall
BACKGROUND: The incidence of type 1 diabetes (T1D) is increasing globally. One hypothesis is that increasing childhood obesity rates may explain part of this increase, but, as T1D is rare, intervention studies are challenging to perform. The aim of this study was to assess this hypothesis with a Mendelian randomization approach that uses genetic variants as instrumental variables to test for causal associations. METHODS AND FINDINGS: We created a genetic instrument of 23 single nucleotide polymorphisms (SNPs) associated with childhood adiposity in children aged 2-10 years...
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28763442/counting-stillbirths-and-achieving-accountability-a-global-health-priority
#14
Zulfiqar A Bhutta
In a Perspective, Zulfiqar Bhutta discusses the importance of regular and timely reporting on stillbirths.
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28746372/multidrug-resistant-gonorrhea-a-research-and-development-roadmap-to-discover-new-medicines
#15
Emilie Alirol, Teodora E Wi, Manju Bala, Maria Luiza Bazzo, Xiang-Sheng Chen, Carolyn Deal, Jo-Anne R Dillon, Ranmini Kularatne, Jutta Heim, Rob Hooft van Huijsduijnen, Edward W Hook, Monica M Lahra, David A Lewis, Francis Ndowa, William M Shafer, Liz Tayler, Kimberly Workowski, Magnus Unemo, Manica Balasegaram
Emilie Alirol and colleagues discuss the development of new treatments for gonorrhea.
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28742880/same-day-hiv-testing-with-initiation-of-antiretroviral-therapy-versus-standard-care-for-persons-living-with-hiv-a-randomized-unblinded-trial
#16
Serena P Koenig, Nancy Dorvil, Jessy G Dévieux, Bethany L Hedt-Gauthier, Cynthia Riviere, Mikerlyne Faustin, Kerlyne Lavoile, Christian Perodin, Alexandra Apollon, Limathe Duverger, Margaret L McNairy, Kelly A Hennessey, Ariadne Souroutzidis, Pierre-Yves Cremieux, Patrice Severe, Jean W Pape
BACKGROUND: Attrition during the period from HIV testing to antiretroviral therapy (ART) initiation is high worldwide. We assessed whether same-day HIV testing and ART initiation improves retention and virologic suppression. METHODS AND FINDINGS: We conducted an unblinded, randomized trial of standard ART initiation versus same-day HIV testing and ART initiation among eligible adults ≥18 years old with World Health Organization Stage 1 or 2 disease and CD4 count ≤500 cells/mm3...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28742869/ultrasound-non-invasive-measurement-of-intracranial-pressure-in-neurointensive-care-a-prospective-observational-study
#17
Chiara Robba, Danilo Cardim, Tamara Tajsic, Justine Pietersen, Michael Bulman, Joseph Donnelly, Andrea Lavinio, Arun Gupta, David K Menon, Peter J A Hutchinson, Marek Czosnyka
BACKGROUND: The invasive nature of the current methods for monitoring of intracranial pressure (ICP) has prevented their use in many clinical situations. Several attempts have been made to develop methods to monitor ICP non-invasively. The aim of this study is to assess the relationship between ultrasound-based non-invasive ICP (nICP) and invasive ICP measurement in neurocritical care patients. METHODS AND FINDINGS: This was a prospective, single-cohort observational study of patients admitted to a tertiary neurocritical care unit...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28742833/translational-approaches-to-coagulopathy-after-trauma-towards-targeted-treatment
#18
Mitchell Jay Cohen
Mitchell J. Cohen discusses why trauma care must go beyond restoring perfusion to target disorders of inflammation and coagulation in severely injured patients.
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28742829/community-burden-of-undiagnosed-hiv-infection-among-adolescents-in-zimbabwe-following-primary-healthcare-based-provider-initiated-hiv-testing-and-counselling-a-cross-sectional-survey
#19
Victoria Simms, Ethel Dauya, Subathira Dakshina, Tsitsi Bandason, Grace McHugh, Shungu Munyati, Prosper Chonzi, Katharina Kranzer, Getrude Ncube, Collen Masimirembwa, Roslyn Thelingwani, Tsitsi Apollo, Richard Hayes, Helen A Weiss, Rashida A Ferrand
BACKGROUND: Children living with HIV who are not diagnosed in infancy often remain undiagnosed until they present with advanced disease. Provider-initiated testing and counselling (PITC) in health facilities is recommended for high-HIV-prevalence settings, but it is unclear whether this approach is sufficient to achieve universal coverage of HIV testing. We aimed to investigate the change in community burden of undiagnosed HIV infection among older children and adolescents following implementation of PITC in Harare, Zimbabwe...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28742819/the-science-of-rapid-start-from-the-when-to-the-how-of-antiretroviral-initiation
#20
Elvin H Geng, Diane V Havlir
In this Perspective linked to Koenig and colleagues, Elvin Geng and Diane Havlir discuss the next challenges for implementation research around rapid start antiretroviral treatment.
July 2017: PLoS Medicine
journal
journal
40821
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"