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Pharmacogenetics and Genomics

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https://www.readbyqxmd.com/read/29901526/the-hemodynamic-response-to-constant-dobutamine-infusion-the-effect-of-adrb1-389-polymorphism-and-sex-erratum
#1
(no author information available yet)
No abstract text is available yet for this article.
July 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29901525/in-memoriam-wendell-w-weber-phd-md-1925-2018
#2
David W Hein, Paul F Hollenberg, Charlene A McQueen, Irene B Glowinski
No abstract text is available yet for this article.
July 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29847509/brain-neurotransmitter-transporter-receptor-genomics-and-efavirenz-central-nervous-system-adverse-events
#3
David W Haas, Yuki Bradford, Anurag Verma, Shefali S Verma, Joseph J Eron, Roy M Gulick, Sharon A Riddler, Paul E Sax, Eric S Daar, Gene D Morse, Edward P Acosta, Marylyn D Ritchie
OBJECTIVE: We characterized associations between central nervous system (CNS) adverse events and brain neurotransmitter transporter/receptor genomics among participants randomized to efavirenz-containing regimens in AIDS Clinical Trials Group studies in the USA. PARTICIPANTS AND METHODS: Four clinical trials randomly assigned treatment-naive participants to efavirenz-containing regimens. Genome-wide genotype and PrediXcan were used to infer gene expression levels in tissues including 10 brain regions...
July 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29781872/nat2-ultra-slow-acetylator-and-risk-of-anti-tuberculosis-drug-induced-liver-injury-a-genotype-based-meta-analysis
#4
Supharat Suvichapanich, Koya Fukunaga, Hilyatuz Zahroh, Taisei Mushiroda, Surakameth Mahasirimongkol, Licht Toyo-Oka, Usa Chaikledkaew, Jiraphun Jittikoon, Rika Yuliwulandari, Hideki Yanai, Sukanya Wattanapokayakit, Katsushi Tokunaga
BACKGROUND: NAT2 slow acetylator is a confirmed risk of anti-tuberculosis drug-induced liver injury (ATDILI). However, NAT2 ultra-slow acetylators, a new refinement among NAT2 slow acetylators, have been recently proposed. The patients with NAT2 genotypes of *6A/*6A, *6A/*7B and *7B/*7B are referred to in this group. OBJECTIVE: We aim to prove an association of the NAT2 ultra-slow acetylators with the risk of ATDILI. MATERIALS AND METHODS: Systematic review and meta-analysis were performed based on each NAT2 genotype and risk of ATDILI cases and also new classification of the ultra-slow acetylators up to 31 October 2016...
July 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29768303/post-mortem-analysis-of-suicide-victims-shows-abcb1-haplotype-1236t-2677t-3435t-as-a-candidate-predisposing-factor-behind-adverse-drug-reactions-in-females-erratum
#5
(no author information available yet)
No abstract text is available yet for this article.
June 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29768302/pharmacogenomics-in-papua-new-guineans-unique-profiles-and-implications-for-enhancing-drug-efficacy-while-improving-drug-safety
#6
Joseph D Tucci, Paul P Pumuye, Nuala A Helsby, Daniel T Barratt, Percy P Pokeya, Francis Hombhanje, Andrew A Somogyi
Papua New Guinea (PNG) can be roughly divided into highland, coastal and island peoples with significant mitochondrial DNA differentiation reflecting early and recent distinct migrations from Africa and East Asia, respectively. Infectious diseases such as tuberculosis, malaria and HIV severely impact on the health of its peoples for which drug therapy is the major treatment and pharmacogenetics has clinical relevance for many of these drugs. Although there is generally little information about known single nucleotide polymorphisms in the population, in some instances, their frequencies have been shown to be higher than anywhere worldwide...
June 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29768301/germline-genome-wide-association-studies-in-women-receiving-neoadjuvant-chemotherapy-with-or-without-bevacizumab
#7
James N Ingle, Krishna R Kalari, Donald Lawrence Wickerham, Gunter von Minckwitz, Peter A Fasching, Yoichi Furukawa, Taisei Mushiroda, Matthew P Goetz, Poulami Barman, Erin E Carlson, Priya Rastogi, Joseph P Costantino, Junmei Cairns, Soonmyung Paik, Harry D Bear, Michiaki Kubo, Liewei Wang, Norman Wolmark, Richard M Weinshilboum
Neoadjuvant chemotherapy (NAC) for breast cancer is widely utilized, and we performed genome-wide association studies (GWAS) to determine whether germ-line genetic variability was associated with benefit in terms of pathological complete response (pCR), disease-free survival, and overall survival in patients entered on the NSABP B-40 NAC trial, wherein patients were randomized to receive, or not, bevacizumab in addition to chemotherapy. Patient DNA samples were genotyped with the Illumina OmniExpress BeadChip...
June 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29768300/the-hemodynamic-response-to-constant-dobutamine-infusion-the-effect-of-adrb1-389-polymorphism-and-sex
#8
Dotan Yogev, Maamoun Basheer, Amichai Perlman, Simcha Blotnick, Yoseph Caraco, Mordechai Muszkat
OBJECTIVES: Prolonged activation of the β-1 adrenergic receptor (ADRB1) is associated with receptor desensitization. This process has been suggested to have important pathophysiological and clinical implications in conditions such as congestive heart failure. The contribution of genetic factors to this process is a patient of ongoing research. We have previously shown that the ADRB1 389 polymorphism affects the response to incremental dose infusion of the ADRB agonist dobutamine. The aim of the current study was to determine whether the ADRB1 389 polymorphism affects the hemodynamic response to constant dose infusion of dobutamine in healthy patients...
June 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29677090/pharmgkb-summary-very-important-pharmacogene-information-for-abcg2-erratum
#9
(no author information available yet)
No abstract text is available yet for this article.
May 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29677089/re-the-recent-paper-genetic-determinants-of-impaired-awareness-of-hypoglycaemia-in-type-1-diabetes
#10
Ulrik Pedersen-Bjergaard, Birger Thorsteinsson
No abstract text is available yet for this article.
May 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29642234/a-retrospective-investigation-of-hla-b-5801-in-hyperuricemia-patients-in-a-han-population-of-china
#11
Heng Cheng, Dewen Yan, Xin Zuo, Junying Liu, Wenlan Liu, Youming Zhang
BACKGROUND: Hyperuricemia and gout have become increasingly prevalent in China. Allopurinol is an effective urate-lowering therapy, but it has severe side effects. HLA-B*5801 is highly associated with the allopurinol-induced toxic epidermal necrolysis and Stevens-Johnson syndrome. PATIENTS AND METHODS: In this retrospective report, we had genotyped HLA-B*5801 in 253 cases of hyperuricemia and gout patients in a Han population in Shenzhen and analyzed the clinical management of medications...
May 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29517518/pharmgkb-summary-atazanavir-pathway-pharmacokinetics-pharmacodynamics
#12
Maria Alvarellos, Chantal Guillemette, Russ B Altman, Teri E Klein
No abstract text is available yet for this article.
May 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29517622/pharmgkb-summary-clobazam-pathway-pharmacokinetics
#13
Rachel Huddart, J Steven Leeder, Russ B Altman, Teri E Klein
No abstract text is available yet for this article.
April 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29517621/reply-to-searcy-and-colleagues
#14
Chad A Bousman, Philip Jaksa, Christos Pantelis
No abstract text is available yet for this article.
April 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29517620/response-to-the-article-by-bousman-and-colleagues-systematic-evaluation-of-commercial-pharmacogenetic-testing-in-psychiatry
#15
Isabelle Iltis-Searcy, Mathura Shanmugasundaram, Bronwyn Ramey-Hartung, Hennessy McIlvaine, Ross Higgins
No abstract text is available yet for this article.
April 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29481489/post-mortem-analysis-of-suicide-victims-shows-abcb1-haplotype-1236t-2677t-3435t-as-a-candidate-predisposing-factor-behind-adverse-drug-reactions-in-females
#16
Anna-Liina Rahikainen, Jukka U Palo, Jari Haukka, Antti Sajantila
BACKGROUND: Genetic variation in efflux transporter, permeability glycoprotein (P-gp), has recently been associated with completed violent suicides and also violent suicide attempts. As depression is known to be a risk factor for suicide and many antidepressants are P-gp substrates, it has been speculated that inadequate antidepressant treatment response or adverse side effects could be involved. OBJECTIVES: The aim of this study was to investigate whether there is an association between the P-gp coding ABCB1 gene and completed suicides in citalopram users...
April 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29360682/ontogeny-related-pharmacogene-changes-in-the-pediatric-liver-transcriptome
#17
Richard Meier, Chengpeng Bi, Roger Gaedigk, Daniel P Heruth, Shui Qing Ye, J Steven Leeder, Brooke L Fridley
OBJECTIVES: The majority of drug dosing studies are based on adult populations, with modification of the dosing for children based on size and weight. This rudimentary approach for drug dosing children is limited, as biologically a child can differ from an adult in far more aspects than just size and weight. Specifically, understanding the ontogeny of childhood liver development is critical in dosing drugs that are metabolized through the liver, as the rate of metabolism determines the duration and intensity of a drug's pharmacologic action...
March 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29329142/whole-genome-methylation-profiling-of-peripheral-blood-mononuclear-cell-for-acute-exacerbations-of-chronic-obstructive-pulmonary-disease-treated-with-corticosteroid
#18
Shih-Wei Lee, Julia Tzu-Ya Weng, Paul Wei-Che Hsu, Tzu-Yi Chuang, Chih-Wei Liu, Chung-Hsuan Chen, Lawrence Shih-Hsin Wu
OBJECTIVE: Although association studies in the general population may be relevant for determining susceptibility to chronic obstructive pulmonary disease (COPD), they may be less applicable for pharmacogenetics research in participants who have already acquired the disease. PATIENTS AND METHODS: A genome-wide methylation profiling (generated by HumanMethylation450 BeadChips study was performed on peripheral blood mononuclear cells of 24 patients with AECOPD (acute exacerbation COPD), with good and poor responsiveness to standard corticosteroid treatment...
March 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29239905/specific-association-of-the-rs6500265-and-rs9933632-single-nucleotide-polymorphisms-in-japanese-patients-with-antipyretic-analgesic-related-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-with-severe-ocular-involvements
#19
Yoshimi Okamoto-Uchida, Ryosuke Nakamura, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito
A recent study using the microarray for single-nucleotide polymorphisms (SNPs) genotyping specifically designed for the Japanese population in combination with genome-wide imputation showed the association of several SNPs with cold medicine-related Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with severe ocular complications. However, it remains to be determined whether these polymorphisms are associated with the onset of antipyretic analgesic (AA)-related SJS/TEN, the progression of severe ocular involvements (SOIs), or both AA-related SJS/TEN and SOI phenotypes...
March 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29232306/differential-effect-of-abcb1-haplotypes-on-promoter-activity
#20
Jordan T Speidel, Meixiang Xu, Sherif Z Abdel-Rahman
OBJECTIVE: Promoter single-nucleotide polymorphisms (SNPs) of the ABCB1 gene, encoding the placental efflux transporter P-glycoprotein, can affect its expression and alter xenobiotic transfer from the maternal to the fetal circulation. Because SNPs are arranged in specific combinations as defined haplotypes, the aims of this study were to: (i) determine the placental haplotype structure of the ABCB1 promoter and (ii) determine the differential effect of these haplotypes on placental ABCB1 promoter activity...
March 2018: Pharmacogenetics and Genomics
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