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Pharmacogenetics and Genomics

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https://www.readbyqxmd.com/read/30188374/pharmacogenetic-and-clinical-predictors-of-response-to-clopidogrel-plus-aspirin-after-acute-coronary-syndrome-in-egyptians
#1
Shaimaa Fathy, Mohamed H Shahin, Taimour Langaee, Basma M Khalil, Ayman Saleh, Nagwa A Sabry, Mona F Schaalan, Lamiaa L El Wakeel, Larisa H Cavallari
OBJECTIVES: Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel reduces the risk for recurrent cardiovascular events after acute coronary syndrome (ACS). However, there is significant variation in response to DAPT that may be influenced by both genetic and nongenetic factors. This study aimed to assess the effect of genetic polymorphisms in PON-1, PEAR-1, P2Y12, CES1, and CYP2C19, along with clinical, demographic, and social factors, on variation in response to DAPT in Egyptians...
September 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/30179981/role-of-cyp1a1-abcg2-cyp24a1-and-vdr-gene-polymorphisms-on-the-evaluation-of-cardiac-iron-overload-in-thalassaemia-patients
#2
Sarah Allegra, Jessica Cusato, Silvia De Francia, Filomena Longo, Elisa Pirro, Davide Massano, Valeria Avataneo, Amedeo De Nicolò, Antonio Piga, Antonio D'Avolio
OBJECTIVES: Iron-burden-induced arrhythmia and heart failure are among the leading causes of morbidity and mortality in β-thalassaemia major patients. T2* cardiac magnetic resonance remains the only reliable noninvasive method for the heart iron excess assessment. We explored the role of single nucleotide polymorphisms involved in vitamin D metabolism, transport and activity and in deferasirox (DFX) metabolism on cardiac iron burden. PATIENTS AND METHODS: One hundred and five β-thalassaemia patients, treated with DFX, were enrolled in the present study...
September 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/30134346/pharmgkb-summary-clozapine-pathway-pharmacokinetics
#3
Caroline F Thorn, Daniel J Müller, Russ B Altman, Teri E Klein
No abstract text is available yet for this article.
September 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/30169473/pharmgkb-summary-voriconazole-pathway-pharmacokinetics-erratum
#4
(no author information available yet)
No abstract text is available yet for this article.
August 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/30169472/genetic-determinants-of-impaired-awareness-of-hypoglycemia-in-type-1-diabetes
#5
Bas J Schouwenberg, Bastiaan E de Galan
No abstract text is available yet for this article.
August 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/30119132/genetic-polymorphisms-in-candidate-genes-are-not-associated-with-increased-vincristine-related-peripheral-neuropathy-in-arab-children-treated-for-acute-childhood-leukemia-a-single-institution-study
#6
Nathalie K Zgheib, Khaled M Ghanem, Hani Tamim, Carole Aridi, Randa Shahine, Nidale Tarek, Raya Saab, Miguel R Abboud, Hassan El-Solh, Samar A Muwakkit
OBJECTIVE: The aim of this study was to evaluate the potential association between candidate genetic polymorphisms and vincristine-related peripheral neuropathy in Arab children with acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: This is a retrospective evaluation of 133 Arab children treated for ALL at the Children's Cancer Center of Lebanon. Incidence and severity of, as well as the timing (in weeks) at which grade 2 or higher peripheral neuropathy occurred were recorded...
August 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29901526/the-hemodynamic-response-to-constant-dobutamine-infusion-the-effect-of-adrb1-389-polymorphism-and-sex-erratum
#7
(no author information available yet)
No abstract text is available yet for this article.
July 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29901525/in-memoriam-wendell-w-weber-phd-md-1925-2018
#8
David W Hein, Paul F Hollenberg, Charlene A McQueen, Irene B Glowinski
No abstract text is available yet for this article.
July 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29847509/brain-neurotransmitter-transporter-receptor-genomics-and-efavirenz-central-nervous-system-adverse-events
#9
David W Haas, Yuki Bradford, Anurag Verma, Shefali S Verma, Joseph J Eron, Roy M Gulick, Sharon A Riddler, Paul E Sax, Eric S Daar, Gene D Morse, Edward P Acosta, Marylyn D Ritchie
OBJECTIVE: We characterized associations between central nervous system (CNS) adverse events and brain neurotransmitter transporter/receptor genomics among participants randomized to efavirenz-containing regimens in AIDS Clinical Trials Group studies in the USA. PARTICIPANTS AND METHODS: Four clinical trials randomly assigned treatment-naive participants to efavirenz-containing regimens. Genome-wide genotype and PrediXcan were used to infer gene expression levels in tissues including 10 brain regions...
July 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29781872/nat2-ultra-slow-acetylator-and-risk-of-anti-tuberculosis-drug-induced-liver-injury-a-genotype-based-meta-analysis
#10
Supharat Suvichapanich, Koya Fukunaga, Hilyatuz Zahroh, Taisei Mushiroda, Surakameth Mahasirimongkol, Licht Toyo-Oka, Usa Chaikledkaew, Jiraphun Jittikoon, Rika Yuliwulandari, Hideki Yanai, Sukanya Wattanapokayakit, Katsushi Tokunaga
BACKGROUND: NAT2 slow acetylator is a confirmed risk of anti-tuberculosis drug-induced liver injury (ATDILI). However, NAT2 ultra-slow acetylators, a new refinement among NAT2 slow acetylators, have been recently proposed. The patients with NAT2 genotypes of *6A/*6A, *6A/*7B and *7B/*7B are referred to in this group. OBJECTIVE: We aim to prove an association of the NAT2 ultra-slow acetylators with the risk of ATDILI. MATERIALS AND METHODS: Systematic review and meta-analysis were performed based on each NAT2 genotype and risk of ATDILI cases and also new classification of the ultra-slow acetylators up to 31 October 2016...
July 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29768303/post-mortem-analysis-of-suicide-victims-shows-abcb1-haplotype-1236t-2677t-3435t-as-a-candidate-predisposing-factor-behind-adverse-drug-reactions-in-females-erratum
#11
(no author information available yet)
No abstract text is available yet for this article.
June 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29768302/pharmacogenomics-in-papua-new-guineans-unique-profiles-and-implications-for-enhancing-drug-efficacy-while-improving-drug-safety
#12
Joseph D Tucci, Paul P Pumuye, Nuala A Helsby, Daniel T Barratt, Percy P Pokeya, Francis Hombhanje, Andrew A Somogyi
Papua New Guinea (PNG) can be roughly divided into highland, coastal and island peoples with significant mitochondrial DNA differentiation reflecting early and recent distinct migrations from Africa and East Asia, respectively. Infectious diseases such as tuberculosis, malaria and HIV severely impact on the health of its peoples for which drug therapy is the major treatment and pharmacogenetics has clinical relevance for many of these drugs. Although there is generally little information about known single nucleotide polymorphisms in the population, in some instances, their frequencies have been shown to be higher than anywhere worldwide...
June 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29768301/germline-genome-wide-association-studies-in-women-receiving-neoadjuvant-chemotherapy-with-or-without-bevacizumab
#13
James N Ingle, Krishna R Kalari, Donald Lawrence Wickerham, Gunter von Minckwitz, Peter A Fasching, Yoichi Furukawa, Taisei Mushiroda, Matthew P Goetz, Poulami Barman, Erin E Carlson, Priya Rastogi, Joseph P Costantino, Junmei Cairns, Soonmyung Paik, Harry D Bear, Michiaki Kubo, Liewei Wang, Norman Wolmark, Richard M Weinshilboum
Neoadjuvant chemotherapy (NAC) for breast cancer is widely utilized, and we performed genome-wide association studies (GWAS) to determine whether germ-line genetic variability was associated with benefit in terms of pathological complete response (pCR), disease-free survival, and overall survival in patients entered on the NSABP B-40 NAC trial, wherein patients were randomized to receive, or not, bevacizumab in addition to chemotherapy. Patient DNA samples were genotyped with the Illumina OmniExpress BeadChip...
June 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29768300/the-hemodynamic-response-to-constant-dobutamine-infusion-the-effect-of-adrb1-389-polymorphism-and-sex
#14
Dotan Yogev, Maamoun Basheer, Amichai Perlman, Simcha Blotnick, Yoseph Caraco, Mordechai Muszkat
OBJECTIVES: Prolonged activation of the β-1 adrenergic receptor (ADRB1) is associated with receptor desensitization. This process has been suggested to have important pathophysiological and clinical implications in conditions such as congestive heart failure. The contribution of genetic factors to this process is a patient of ongoing research. We have previously shown that the ADRB1 389 polymorphism affects the response to incremental dose infusion of the ADRB agonist dobutamine. The aim of the current study was to determine whether the ADRB1 389 polymorphism affects the hemodynamic response to constant dose infusion of dobutamine in healthy patients...
June 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29677090/pharmgkb-summary-very-important-pharmacogene-information-for-abcg2-erratum
#15
(no author information available yet)
No abstract text is available yet for this article.
May 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29677089/re-the-recent-paper-genetic-determinants-of-impaired-awareness-of-hypoglycaemia-in-type-1-diabetes
#16
Ulrik Pedersen-Bjergaard, Birger Thorsteinsson
No abstract text is available yet for this article.
May 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29642234/a-retrospective-investigation-of-hla-b-5801-in-hyperuricemia-patients-in-a-han-population-of-china
#17
Heng Cheng, Dewen Yan, Xin Zuo, Junying Liu, Wenlan Liu, Youming Zhang
BACKGROUND: Hyperuricemia and gout have become increasingly prevalent in China. Allopurinol is an effective urate-lowering therapy, but it has severe side effects. HLA-B*5801 is highly associated with the allopurinol-induced toxic epidermal necrolysis and Stevens-Johnson syndrome. PATIENTS AND METHODS: In this retrospective report, we had genotyped HLA-B*5801 in 253 cases of hyperuricemia and gout patients in a Han population in Shenzhen and analyzed the clinical management of medications...
May 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29517518/pharmgkb-summary-atazanavir-pathway-pharmacokinetics-pharmacodynamics
#18
Maria Alvarellos, Chantal Guillemette, Russ B Altman, Teri E Klein
No abstract text is available yet for this article.
May 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29517622/pharmgkb-summary-clobazam-pathway-pharmacokinetics
#19
Rachel Huddart, J Steven Leeder, Russ B Altman, Teri E Klein
No abstract text is available yet for this article.
April 2018: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29517621/reply-to-searcy-and-colleagues
#20
Chad A Bousman, Philip Jaksa, Christos Pantelis
No abstract text is available yet for this article.
April 2018: Pharmacogenetics and Genomics
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