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International Wound Journal

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https://www.readbyqxmd.com/read/29781247/the-modified-souquet-flap-for-reconstruction-of-fingertip-amputations
#1
LETTER
Marco Roberto Correia Duarte, Charles Yuen Yung Loh, Zeeshan Ahmad
No abstract text is available yet for this article.
May 21, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29781208/a-useful-alternative-surgical-technique-to-reconstructing-large-defects-following-excision-of-recurrent-pilonidal-sinus-disease-in-the-intergluteal-region-an-operative-approach-for-the-transverse-lumbar-artery-perforator-flap
#2
Alethea My Tan, Zeeshan Ahmad, Charles Yy Loh, Sonya Gardiner, Bhagwat Mathur
The reconstruction of defects in the intergluteal region following pilonidal sinus excision is challenging due to its anatomical location, close proximity to the anus, and being a high-tension area prone to wound-healing problems. Excision and primary closure is known to carry a higher risk of recurrence and subsequent complications compared with using nearby local healthy tissue, such as a flap, to reconstruct defect. Extra due diligence should be given to patient selection and flap choice when deciding the reconstruction of a defect...
May 21, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29781178/the-effects-of-platelet-rich-plasma-on-hypertrophic-scars-fibroblasts
#3
Seung Min Nam, Yong Bae Kim
We hypothesised that a feedback mechanism of the transforming growth factor (TGF)-β1 signalling pathway, triggered by high-level TGF-β1, activates platelet-rich plasma (PRP) release to reduce connective tissue growth factor (CTGF) production and expression of CTGF mRNA in hypertrophic scar dermal fibroblasts. Primary dermal fibroblasts were isolated from cultures of hypertrophic scars. Cells were cultured after addition of serum-free Dulbecco's modified Eagle's medium supplemented with 5% (wt/vol) PRP or platelet-poor plasma (PPP)...
May 21, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29767853/nicorandil-induced-ulcerations-a-10-year-observational-study-of-all-cases-spontaneously-reported-to-the-french-pharmacovigilance-network
#4
Valérie Babic, Nadine Petitpain, Claire Guy, Philippe Trechot, Anne Claire Bursztejn, Jean Luc Faillie, Thierry Vial, Jean Luc Schmutz, Pierre Gillet
Nicorandil-induced ulcers remain often poorly recognised, with a late diagnosis and an inadequate management. We aimed to provide a clinical overview of the 148 spontaneously reported cases of nicorandil-induced ulcers to the French pharmacovigilance network between 2005 and 2014 and to complete this picture with worldwide published cases over the same period. Spontaneously reported nicorandil-induced ulcers were mainly mucosal (oral and anal) with a previous trauma in 23·0% of patients, revealed by a severe complication in 12·8% of cases...
May 16, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29745047/systematic-review-of-the-efficacy-of-fat-grafting-and-platelet-rich-plasma-for-wound-healing
#5
Oliver J Smith, Muholan Kanapathy, Ankur Khajuria, Max Prokopenko, Nadine Hachach-Haram, Haroon Mann, Ash Mosahebi
Adipose-derived stem cells found in fat grafts may have significant healing properties. When fat is combined with autologous platelet-rich plasma (PRP), there may be enhanced healing effects due to the pro-angiogenic and anti-inflammatory effects of PRP. This study aimed to evaluate the current evidence on fat grafting in combination with PRP for wound healing to establish the efficacy of this technique. A comprehensive search in the MEDLINE, EMBASE, CENTRAL, Science Citation Index, and Google Scholar databases (to March 2017) was conducted to identify studies on fat grafting and PRP for wound healing...
May 9, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29696785/bromelain-based-enzymatic-debridement-of-chronic-wounds-a-preliminary-report
#6
Yaron Shoham, Yuval Krieger, Eran Tamir, Eldad Silberstein, Alexander Bogdanov-Berezovsky, Josef Haik, Lior Rosenberg
Sharp debridement is currently considered most effective for debridement of chronic wounds; however, some patients do not have access to or cannot be treated by surgical methods. This study was designed to provide a first impression of the safety and efficacy of bromelain-based enzymatic debridement of chronic wounds. Two consecutive single-arm studies assessing the enzymatic debridement efficacy of a concentrate of proteolytic enzymes enriched in bromelain in chronic wounds was conducted in 2 medical centres...
April 25, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29683259/genital-ulcers-as-diagnostic-clue-for-acute-myeloid-leukaemia
#7
Sina D Schröder, Stefan W Krause, Cornelia Erfurt-Berge
Acute myeloid leukaemia is a myeloid neoplasm with an extremely varying clinical appearance. Skin lesions are common for specific subtypes of acute myeloid leukaemia but are often misinterpreted. Here, we present a case of acute myeloid leukaemia in a young woman exhibiting genital ulcerations and gingival erosions.
April 23, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29682897/an-aseptically-processed-acellular-reticular-allogenic-human-dermis-improves-healing-in-diabetic-foot-ulcers-a-prospective-randomised-controlled-multicentre-follow-up-trial
#8
Charles M Zelen, Dennis P Orgill, Thomas E Serena, Robert E Galiano, Marissa J Carter, Lawrence A DiDomenico, Jennifer Keller, Jarrod P Kaufman, William W Li
Aseptically processed human reticular acellular dermal matrix (HR-ADM) has been previously shown to improve wound closure in 40 diabetic patients with non-healing foot ulcers. The study was extended to 40 additional patients (80 in total) to validate and extend the original findings. The entire cohort of 80 patients underwent appropriate offloading and standard of care (SOC) during a 2-week screening period and, after meeting eligibility criteria, were randomised to receive weekly applications of HR-ADM plus SOC or SOC alone for up to 12 weeks...
April 22, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29675986/efficacy-and-safety-of-extracorporeal-shock-wave-therapy-for-acute-and-chronic-soft-tissue-wounds-a-systematic-review-and-meta-analysis
#9
Li Zhang, Xiao-Bing Fu, Shuo Chen, Zhan-Bo Zhao, Christoph Schmitz, Chang-Shui Weng
This study aimed to evaluate and compare the effects of extracorporeal shock wave therapy (ESWT) and conventional wound therapy (CWT) for acute and chronic soft tissue wounds. All English-language articles on ESWT for acute and chronic soft tissue wounds indexed in PubMed, Medline, Embase, Cochrane Central Register of Controlled Trials, Cochrane Library, Physiotherapy Evidence Database, and HealthSTAR published prior to June 2017 were included, as well as corresponding articles cited in reference lists of related review articles...
April 19, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29665271/pressure-heel-ulcers-in-patients-with-type-2-diabetes-is-it-t-i-m-e-to-customise-wound-bed-preparation-according-to-different-heel-areas
#10
LETTER
Ilaria Teobaldi, Alessandro Mantovani
No abstract text is available yet for this article.
April 17, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29659146/curcumin-accelerates-cutaneous-wound-healing-via-multiple-biological-actions-the-involvement-of-tnf-%C3%AE-mmp-9-%C3%AE-sma-and-collagen
#11
Yu-Hsiu Yen, Chi-Ming Pu, Chen-Wei Liu, Ya-Chun Chen, Yu-Chen Chen, Chan-Jung Liang, Jung-Hsien Hsieh, Hui-Fu Huang, Yuh-Lien Chen
Curcumin, a constituent of the turmeric plant, has antitumor, anti-inflammatory, and antioxidative effects, but its effects on wound healing are unclear. We created back wounds in 72 mice and treated them with or without topical curcumin (0.2 mg/mL) in Pluronic F127 gel (20%) daily for 3, 5, 7, 9, and 12 days. Healing in wounds was evaluated from gross appearance, microscopically by haematoxylin and eosin staining, by immunohistochemistry for tumour necrosis factor alpha and alpha smooth muscle actin, and by polymerase chain reaction amplification of mRNA expression levels...
April 16, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29635842/a-randomised-controlled-trial-of-the-clinical-effectiveness-of-multi-layer-silicone-foam-dressings-for-the-prevention-of-pressure-injuries-in-high-risk-aged-care-residents-the-border-iii-trial
#12
Nick Santamaria, Marie Gerdtz, Suzanne Kapp, Lauren Wilson, Amit Gefen
Pressure injuries are prevalent in highly dependent aged care residents. This study investigated the clinical effectiveness of the application of the Mepilex Border Sacrum and Mepilex Heel dressings to prevent the development of facility-acquired pressure injuries. A total of 288 recently admitted residents were enrolled from 40 Australian nursing homes into a randomised controlled trial. Residents randomised to standard care (n = 150) received pressure injury prevention as recommended by international guidelines...
April 10, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29600828/an-electrical-plasma-dissection-tool-for-surgical-treatment-of-chronic-ulcers-results-of-a-prospective-randomised-trial
#13
Giovanni F Marangi, Tiziano Pallara, Daniela Lamberti, Eleonora Perrella, Raffaele Serra, Francesco Stilo, Giovanni De Caridi, Andrea Onetti Muda, Paolo Persichetti
Cutaneous ulceration is a difficult medical problem and a major source of morbidity for patients. In the surgical treatment of ulcers, debridement is the first step, and it can be carried out using several surgical tools. Recently, new surgical devices have emerged using plasma-mediated electrical discharges with a lower peak temperature. A prospective single-blind trial was conducted on chronic ulcers not responsive to common non-surgical management. Patients were randomly separated into 2 groups: Group A received surgical debridement with conventional electrocautery, and Group B received surgical debridement using the plasma-mediated device...
March 30, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29600821/an-unusual-presentation-of-a-common-condition-allergic-contact-dermatitis
#14
Annie Price, Natalie M Stone, Keith G Harding
Allergic contact dermatitis commonly affects patients with chronic venous leg ulcers and can contribute to impaired wound healing. Many allergens have been identified, and despite the use of advanced dressings, the incidence of allergy has remained high. We discuss an unusual presentation of allergic contact dermatitis in a patient with a chronic wound. The patient's history was consistent with a recurrent venous leg ulcer, but on this occasion, the wound continued to deteriorate despite optimal treatment. This prompted further investigation, which included patch testing...
March 30, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29600578/successful-treatment-of-enteroatmospheric-fistulas-in-combination-with-negative-pressure-wound-therapy-experience-on-3-cases-and-literature-review
#15
Ulrich Wirth, Bernhard W Renz, Dorian Andrade, Tobias S Schiergens, Helmut Arbogast, Joachim Andrassy, Jens Werner
Enteroatmospheric fistulas (EAF) are rare but challenging and morbid complications of abdominal surgery and require time- as well as resource-consuming management. Furthermore, they severely affect patients' quality of life. Several treatment modalities for EAF management are described in the literature. We describe 3 consecutive cases of EAF treatment by employing negative pressure wound therapy (NPWT) along with either a special silicone fistula adapter or a Silo-Vac-like system in another case to isolate the fistula from the remaining abdominal wound...
March 30, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29600564/statistical-analysis-of-factors-affecting-re-operative-times-in-paediatric-patients-with-scar-deformity-after-deep-second-degree-burn-injury
#16
Baoguo Chen, Xiaotong Yue, Ruijuan Zhang, Huifeng Song
Deep second-degree burn injuries pose a challenge for treating scar deformity in developing paediatric patients. Some patients underwent several re-operations during their development. There was no literature reporting which factors affect re-operative times. In this article, we intend to analyse possible influential factors that are responsible for re-operative times in paediatric patients with scar deformity after deep second-degree burn injuries. From 2010 to 2016, 177 paediatric cases with a history of deep second-degree burn injury who underwent re-operation once, twice, and equal to or more than thrice were recruited to this study, with age ranging from 0 to 18 years...
March 30, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29600562/serum-level-of-endostatin-and-digital-ulcers-in-systemic-sclerosis-patients
#17
Antonietta Gigante, Domenico Margiotta, Luca Navarini, Biagio Barbano, Maria L Gasperini, Claudia D'Agostino, Antonio Amoroso, Antonella Afeltra, Edoardo Rosato
Patients with systemic sclerosis (SSc) are at a high risk of the development of ischaemic digital ulcers (DUs) that can be complicated with infections, gangrene, and osteomyelitis. The aim of this study is to evaluate the role of endostatin in scleroderma DUs.In total, 90 SSc patients were enrolled in this study. Serum endostatin levels and DU assessment were determined in all SSc patients. The serum levels of endostatin significantly increased with progression of capillaroscopic damage (P < .01). The serum levels of endostatin are significantly (P < ...
March 30, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29600560/contact-sensitivity-in-patients-with-venous-leg-ulcer-a-multi-centric-indian-study
#18
Reena Rai, Manjunath M Shenoy, Vishalakshi Viswanath, Nilendu Sarma, Imran Majid, Sunil Dogra
Venous leg ulcers are the most common form of non-healing leg ulcers. They are subjected to treatments such as topical medications, dressings, and compression therapies. This can lead to exposure to a number of allergens with subsequent sensitisation and contact dermatitis of the regional skin. This may contribute to the poor ulcer healing. To detect the various contact sensitisers in patients with venous leg ulcers through patch testing, patients from 6 centres across India with venous leg ulcers of longer than 6 weeks duration were enrolled for the study...
March 30, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29600545/strategies-to-support-pressure-injury-best-practices-by-the-inter-professional-team-a-systematic-review
#19
Grace Suva, Tanvi Sharma, Karen E Campbell, Ronald Gary Sibbald, Diana An, Kevin Woo
Optimal pressure injury (ulcer) management by the inter-professional team requires appropriate health care system and organisational resources, infrastructure, and policies. A systematic review was conducted on pressure injury care-related education and health care system-/organisation-level strategies. A search for relevant articles published between January 2006 and October 2014 was applied to 8 databases. Ultimately, 22 articles pertaining to education and training and 12 articles pertaining to health care system and organisation supports for pressure injury care were included in the systematic review...
March 30, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29590523/long-term-follow-up-comparison-of-two-different-bi-layer-dermal-substitutes-in-tissue-regeneration-clinical-outcomes-and-histological-findings
#20
Barbara De Angelis, Fabrizio Orlandi, Margarida Fernandes Lopes Morais D'Autilio, Maria G Scioli, Augusto Orlandi, Valerio Cervelli, Pietro Gentile
Double layer dermal substitute (DS) consist of a 3-dimensional collagen structures and a superficial silicon layer that are positioned within the defect provide to promote tissue regeneration in skin wounds. DS often have unique physical characteristics due to differences in manufacturing techniques. The aim of this study is the clinical and histological comparison of Nevelia and Integra double layer DSs in patients with post-traumatic injury wounds. Thirty patients with post-traumatic wounds localised on the inferior limbs were randomised in 2 groups Nevelia or Integra, followed by autologous dermal epidermal graft (DEG)...
March 28, 2018: International Wound Journal
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