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International Wound Journal

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https://www.readbyqxmd.com/read/28508548/a-prospective-evaluation-of-methylene-blue-and-gentian-violet-dressing-for-management-of-chronic-wounds-with-local-infection
#1
Kevin Y Woo, Jolene Heil
The objective of this prospective, non-randomised study was to evaluate the performance of an antibacterial foam dressing containing methylene blue and gentian violet (Hydrofera Blue Classic dressing(®) ) for the management of chronic wounds with local infection. Patients in this study were ≥18 years of age (n = 29), and each had at least one chronic wound ≥1 cm(2) in size that showed signs of localised infection or critical colonisation but with good potential for healing based on clinical assessment...
May 16, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28503756/biofilms-and-delayed-healing%C3%A2-%C3%A2-an-in-vitro-evaluation-of-silver-and-iodine-containing-dressings-and-their-effect-on-bacterial-and-human-cells
#2
Katie A Bourdillon, Craig P Delury, Breda M Cullen
This study investigated whether there are differences in the ability of wound dressings to modulate certain factors known to affect wound healing. A selection of antimicrobial dressings (AQUACEL(®) Ag Extra(™) , AQUACEL(®) Ag+ Extra(™) , IODOFLEX(™) , ACTICOAT(™) 7 and PROMOGRAN PRISMA(™) matrix) were tested for their effect on both bacterial bioburden and human dermal fibroblasts. Some dressings underwent further evaluation for activity against Pseudomonas aeruginosa biofilms using a colony-drip flow reactor model...
May 14, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28488305/the-use-of-medicinal-plants-in-venous-ulcers-a-systematic-review-with-meta-analysis
#3
Anderson L Freitas, Carla A Santos, Carlos As Souza, Marco Ap Nunes, Ângelo R Antoniolli, Wellington B da Silva, Francilene A da Silva
The aim of this study was to systematically review the use of medicinal plants for the treatment of varicose ulcers. The databases used in the search were: Medline/Pubmed, Scopus, Cinhal, Lilacs and Web of Science. The selection process was divided into two phases: the reading of titles and abstracts and the full reading of selected articles. The item description was compared with the checklist of the Consolidated Standards of Reporting Trials. The initial search produced 3505 articles and seven were selected for inclusion in the systematic review...
May 9, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28467018/histological-analysis-of-hyalinised-keloidal-collagen-formation-in-earlobe-keloids-over-time-collagen-hyalinisation-starts-in-the-perivascular-area
#4
Noriko M Matsumoto, Wei-Xia Peng, Masayo Aoki, Satoshi Akaishi, Ryuji Ohashi, Rei Ogawa, Zenya Naito
Keloids grow and do not regress. They are characterised histologically by hyalinised keloidal collagen (HKC). HKC amounts vary, and the mechanism by which they form is unclear. To clarify how HKCs form and whether their formation associates with specific clinical features, we studied the histological findings of earlobe keloids and compared them with respective clinical features. A total of 50 earlobe keloids from 43 patients were used for histological analysis of keloid size (mm(2) ), HKC area (mm(2) ) and HKC area ratio (%)...
May 3, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28448693/embedded-ring-injury%C3%A2-%C3%A2-a-rare-presentation-with-an-atypical-aetiology
#5
Benjamin J Langridge, Saif Ramman, Neil J Toft
A 45-year-old female patient presented to clinic with an almost completely embedded ring in the volar aspect of her right ring finger, with complete reepithelialisation over the superficial aspect of the ring. We present this unusual case of an embedded ring after an insect bite on the patient's ring finger. The patient had worn the ring for the previous 5 years without removing it and did not report any discomfort or traumatic injury. We discuss this case in the context of previously reported cases of an embedded ring, a rare presentation in itself, highlighting the key differences in both this patient's aetiology and the risk factors associated with the presentation...
April 27, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28440050/enzymatic-debridement-with-collagenase-in-wounds-and-ulcers-a-systematic-review-and-meta-analysis
#6
Jérôme Patry, Virginie Blanchette
Enzymatic debridement with collagenase is a technique that is commonly used in clinical practice. This systematic review examines the effect of collagenase on all kinds of wounds, compared to an alternative therapy, on wound healing, wound bed characteristics, cost-effectiveness and the occurrence of adverse events. We conducted a systematic literature search on available literature in Cochrane databases, MEDLINE, EMBASE and CINAHL. Two investigators independently assessed the titles and abstracts of all randomised controlled trials obtained involving collagenase of all kinds of wounds based on inclusion criteria...
April 25, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28440042/biodegradable-hydrogel-based-biomaterials-with-high-absorbent-properties-for-non-adherent-wound-dressing
#7
Alok Kumar, Xiang Wang, Krishna Chaitanya Nune, Rdk Misra
Dressing materials involve conventional gauzes and modern materials such as hydrogels and foam-based biomaterials. Although the choice of dressing material depends on the type of wound, a dressing material is expected to be non-cytotoxic. Additionally, moist dressing is considered appropriate to accelerate epithelialisation, while dry dressing may cause tissue damage during removal. An ideal dressing material is expected to provide a moist environment and degrade and release the drug for faster wound healing...
April 25, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28425207/bcg-vaccination-induced-suppurative-lymphadenitis-four-signs-to-pay-attention-to
#8
Sang Oon Baek, Hyo Sun Ko, Hyun Ho Han
Suppurative lymphadenitis is one of the severe complication after BCG vaccination, but its diagnostic criteria and treatment guidelines have not yet been established. In this article, we describe a case of suppurative lymphadenitis caused by BCG vaccination and propose diagnostic criteria and treatment guidelines of the disease. The lymphadenitis was presented as skin involving mass and was completely extirpated. Pathological evaluation revealed a necrotising lymphadenitis, consistent with the diagnosis of BCG lymphadenitis...
April 19, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28425162/a-small-lick-will-sink-a-great-ship-fulminant-septicaemia-after-dog-saliva-wound-treatment-in-an-asplenic-patient
#9
Evi M Morandi, Reinhard Pauzenberger, Christoph Tasch, Ulrich M Rieger, Gerhard Pierer, Gabriel Djedovic
Capnocytophaga canimorsus is a bacterium transmitted through the saliva of dogs. An infection can cause severe sepsis with acral necrosis and is potentially fatal. Here, we report the case of a 41-year-old man who was infected through a wound that was licked by his dog. He went into septic shock with disseminated intravascular coagulation and subsequently lost both lower legs, his nose and all the fingers on both hands.
April 19, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28419746/factors-for-postoperative-complications-following-pressure-ulcer-operation-stepwise-multiple-logistic-regression-analysis
#10
Hyun Ho Han, Jun Gul Ko, Jong Won Rhie
Patients with pressure ulcers are generally older, have a long hospital stay and often have a variety of comorbidities. The decision to perform surgery for pressure ulcer management can be difficult because of concerns about the risk of postoperative complications. The aim of this study was to analyse the relationship between comorbid conditions and surgical outcomes in order to guide patient selection for pressure ulcer surgery. In 57 patients, data on age, defect size, operating time, hospital stay, body mass index, surgical site, mobility state, cardiac ischaemic history, diabetes, renal failure, ventilator dependency, tracheostomy state, use of haemodilution therapy and cancer were evaluated using stepwise multiple logistic regression analysis to determine the relationships between variables...
April 17, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28414861/management-of-necrotising-fasciitis-secondary-to-abdominal-liposuction-using-a-combination-of-surgery-hyperbaric-oxygen-and-negative-pressure-wound-therapy-in-a-patient-with-burn-scars
#11
I-Han Chiang, Shun-Cheng Chang, Chih-Hsin Wang
Liposuction is the one of the most frequently performed cosmetic operations and usually has an easy recovery, with a reportedly low overall complication rate. Here, we report the case of a 60-year-old woman with type II diabetes mellitus and a previous burn injury of the abdomen who underwent abdominal liposuction and subsequently developed necrotising fasciitis. Following radical debridement, systemic antibiotic administration, negative pressure wound therapy and hyperbaric oxygen therapy, the wound healed completely...
April 17, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28371381/the-potential-benefits-and-harms-of-early-feeding-post-surgery-a-literature-review
#12
Genevieve Abela
The effect of nutrition on wound healing is widely recognized, with many studies highlighting the detrimental effect poor nutrition can have on wound healing. In addition, fasting pre-, peri- and postoperatively can contribute to further protein catabolism, leading to morbidity and mortality. By reviewing the current literature, this work evaluates the potential benefits and harms from early feeding (EF) during the early stages postsurgery. Current randomised control trials suggest that the early introduction of nutrients post-surgery may be beneficial for wound healing and recovery from surgery...
March 29, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28371369/peri-vulvar-reconstruction-using-internal-pudendal-artery-perforator-flap-in-female-fournier-s-gangrene
#13
Sang O Baek, Seong H Park, Jong W Rhie, Hyun H Han
Fournier's gangrene in female patients has low incidence rate but high mortality rate compared with that in males, with many cases resulting in death at acute phase. This is due to the differences in male and female genital anatomy, which should be fully understood by physicians to increase the patient's survival rate. After crossing the acute phase of the disease by an appropriate treatment, it is important to reconstruct vaginal or vulvar defects according to the patient's three-dimensional anatomical structures...
March 29, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28371346/dramatic-resolution-of-disseminated-pyoderma-gangrenosum-associated-with-monoclonal-gammopathy-after-therapy-with-bortezomib-and-dexamethasone
#14
Virginia Velasco-Tamariz, Gonzalo Carreño-Tarragona, Fátima Tous-Romero, Elena Gil-de la Cruz, Estela Martín-Clavero, Raquel Rivera-Díaz
Pyoderma gangrenosum (PG) is an uncommon inflammatory and ulcerative skin disorder, which is commonly associated with systemic conditions such as inflammatory bowel disease, arthritis and haematological malignancies. It is widely stated that control of the underlying diseases may lead to resolution of PG. However, standard of care dictates that patients suffering with monoclonal gammopathy of undetermined significance or smouldering multiple myeloma (MM) should not receive therapy unless they progress to symptomatic MM...
March 29, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28371159/transforming-growth-factor-%C3%AE-1-regulates-the-expression-of-ccn2-in-human-keratinocytes-via-smad-erk-signalling
#15
Elizabeth Kiwanuka, Johan Pe Junker, Elof Eriksson
Connective tissue growth factor (CCN2/CTGF) and transforming growth factor β1 (TGF-β1) are important regulators of skin wound healing, but controversy remains regarding their expression in epithelial cell lineages. Here, we investigate the expression of CCN2 in keratinocytes during reepithelialisation and its regulation by TGF-β1. CCN2 was detected in the epidermis of healing full-thickness porcine wounds. Human keratinocytes were incubated with or without 10 ng/ml TGF-β1, and signalling pathways were blocked with 10-μM SIS3 or 20-μM PD98059...
March 29, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28370981/in-vitro-assessment-of-a-novel-hypothermically-stored-amniotic-membrane-for-use-in-a-chronic-wound-environment
#16
John P McQuilling, Jeremy B Vines, Katie C Mowry
Chronic wounds require extensive healing time and place patients at risk of infection and amputation. Recently, a fresh hypothermically stored amniotic membrane (HSAM) was developed and has subsequently shown promise in its ability to effectively heal chronic wounds. The purpose of this study is to investigate the mechanisms of action that contribute to wound-healing responses observed with HSAM. A proteomic analysis was conducted on HSAM, measuring 25 growth factors specific to wound healing within the grafts...
March 29, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28371354/comment-on-effectiveness-of-a-multi-layer-foam-dressing-in-preventing-sacral-pressure-ulcers-for-the-early-acute-care-of-patients-with-a-traumatic-spinal-cord-injury-comparison-with-the-use-of-a-gel-mattress
#17
LETTER
https://www.readbyqxmd.com/read/28326673/benefits-of-intralesional-injections-of-sodium-thiosulfate-in-the-treatment-of-calciphylaxis
#18
Kirsi Isoherranen, Laura Bouchard, Nicolas Kluger
Calciphylaxis (CPX) is a rare calcifying thrombotic vasculopathy responsible for painful necrotic ulcers, with a high mortality rate, and its management is often difficult. Recently, intravenous infusions of sodium thiosulfate (STS) have shown efficacy. The aim of this study was to assess the efficacy of intralesional STS (IL STS) in four patients. Our aim was to assess the efficacy of IL STS in a prospective mono-centric open study that included four patients with a biopsy-proven cutaneous CPX. Four women (55-84 years old, mean age: 71·2 years) with a uremic (n = 1) or non-uremic CPX (n = 3) and primary hyperparathyroidism induced by teriparatide or after the initiation of oral anti-vitamin K were treated by IL STS (250 mg/ml)...
March 21, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28303689/non-healing-ischaemic-digital-ulcer-in-a-systemic-sclerosis-patient-a-challenging-clinical-case
#19
Sophie Blaise, Matthieu Roustit, Alexandra Forli, Bernard Imbert, Jean-Luc Cracowski
Ischaemic digital ulcers (DUs) are an indicator of the severity of the microangiopathy in patients with systemic sclerosis (SSc). DUs are a frequent complication, affecting about 50% of patients with SSc, and are often recurrent. In cross-sectional studies involving patients with SSc, the frequency of ischaemic DUs was 12-16% with a major impact on hand function and quality of life. Effective therapy for DUs remains elusive. Intravenous iloprost has been demonstrated to have a positive effect on healing of active DUs...
March 16, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28303656/incidence-and-risks-for-surgical-site-infection-after-adult-tibial-plateau-fractures-treated-by-orif-a-prospective-multicentre-study
#20
Yanbin Zhu, Song Liu, Xiaolin Zhang, Wei Chen, Yingze Zhang
Tibial plateau fractures are difficult to treat and more likely complicated by subsequent surgical site infection (SSI). There is limited information about its characteristics and related risk factors for SSI. This study was designed as a prospective and multicentre one to address this issue. From July to 15 November in 2014, 235 patients with tibial plateau fractures were treated by open reduction and internal fixation (ORIF) and followed up with complete data. Twelve patients (5·1%, 12/235) developed SSI, with 2·1% for deep SSI and 3·0% for superficial SSI...
March 16, 2017: International Wound Journal
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