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Journal of Biomedical Nanotechnology

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December 1, 2018: Journal of Biomedical Nanotechnology
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December 1, 2018: Journal of Biomedical Nanotechnology
Chiang-Wen Lee, Stephen Chu-Sung Hu, Feng-Lin Yen, Lee-Fen Hsu, I-Ta Lee, Zih-Chan Lin, Ming-Horng Tsai, Chieh-Liang Huang, Chan-Jung Liang, Yao-Chang Chiang
No abstract text is available yet for this article.
December 1, 2018: Journal of Biomedical Nanotechnology
Seung Hyuck Bang, Ra-Mi Park, Simranjeet Singh Sekhon, Geun Woo Lee, Yang-Hoon Kim, Jiho Min
Liposomes were modified using two different methods. In Method 1, liposomes were modified by mixing whole lysosomal proteins, lipid, and cholesterol before preparation. For Method 2, the liposomes were modified by mixing whole lysosomal proteins after liposome preparation. Method 1-modified liposomes exhibited improved cell mortality compared to Method 2-modified liposomes. The modified liposomes were then evaluated for their antimicrobial activity against lysosomal enzymes, and Escherichia coli did not modify the liposome surface...
December 1, 2018: Journal of Biomedical Nanotechnology
You Lang Zhou, Luzhong Zhang, Zhou Zhou, Wei Liu, Yang Lu, Shumin He, Yajuan Cui, Yongwei Qin, Minhui Hua
The mechanism of Mycobacterium tuberculosis ( M.tb ) evasion of host cell remains elusive. Several microRNAs that are involved in this complex process were identified. miRNA interference-based therapeutics represents an attractive challenge and shows huge potential for disorder treatment. In this study, we found that miR-124-3p expression is significantly decreased in microglia after Mycobacterium marinum ( M.m ) infection. To achieve better target transfection effect, a CD11b antibody and PEI modified nanoparticles-based Nano platform had been developed...
December 1, 2018: Journal of Biomedical Nanotechnology
Zhongqi Chen, Ningfei Ji, Zhengxia Wang, Chaojie Wu, Zhixiao Sun, Yan Li, Fan Hu, Zibin Wang, Mao Huang, Mingshun Zhang
Accumulating evidence indicates that fine particulate matter (PM2.5) exposure is associated with many cardiopulmonary diseases, particularly lung carcinoma. Nevertheless, the underlying biological mechanisms by which PM2.5 exposure initiates and aggravates lung carcinoma remain elusive. In the present study, we collected PM2.5 in Nanjing and explored the mechanisms underlying the oncogenic roles of PM2.5 in the murine lung carcinoma cell line LLC in vitro and in vivo . PM2.5 was closely attached to and internalized by lung cancer cells...
December 1, 2018: Journal of Biomedical Nanotechnology
Niannian Li, Fei Xu, Jiejun Cheng, Ying Zhang, Gang Huang, Jun Zhu, Xi Shen, Dannong He
Amelioration of hypoxia is an important factor increasing the effects of anti-tumor therapies. In the present experiments, nanocapsules of poly(lactide-co-glycolide)-poly(ethylene glycol)/perfluorooctyl bromide (PFOB)/photosensitizers (IR780) have been developed to increase oxygen concentration inside the tumor and improve the outcome of photodynamic therapy (PDT). PFOB has high oxygen solubility, and IR780 is a photosensitizer particularly suited for a highly effective photodynamic therapy under the 808-nm laser irradiation...
December 1, 2018: Journal of Biomedical Nanotechnology
Yuan Liu, Yan Deng, Taotao Li, Zhu Chen, Hui Chen, Song Li, Hongna Liu
A mercury ion aptamer electrochemical biosensor based on a Thymine-Hg2+ -Thymine (T-Hg2+ -T) structure has been constructed and successfully used to detect mercury ions in tap water samples. The aptamer electrochemical biosensor was assembled using a mercury ion aptamer-functionalized AuNPs-modified glass carbon electrode (aptamer/(AuNPs/CS)₂/GCE) capable of specifically detecting mercury ions through a T-Hg2+ -T structure. The experimental results indicated the optimum electrochemical performance of the prepared aptamer biosensor when the (AuNPs/CS)₂/GCE surface was modified with 1...
December 1, 2018: Journal of Biomedical Nanotechnology
Ziwei Sun, Fang Lu, Jinjun Cheng, Meiling Zhang, Yafan Zhu, Yaxue Zhang, Hui Kong, Huihua Qu, Yan Zhao
Although recent research on intrinsic bioactivities of carbon dots is expanding, it is focused on basic aspects, which creates the need for broadening our knowledge about carbon dots to expand their uses in biomedical sciences and facilitate their application in clinical practice. Jiaosanxian is a charcoal traditional Chinese medicine with a pronounced effect on promoting appetite and digestion that is widely used as dyspepsia therapy in China. To study the underlying mechanism and the material requirements, we investigated carbon dots which was generated in the charcoal processing...
December 1, 2018: Journal of Biomedical Nanotechnology
Xiaoyu Chen, Zainen Qin, Jinmin Zhao, Xiaohui Yan, Jing Ye, En Ren, Junqing Wang, Xingchen Yang, Shujun Heng, Li Zheng, Gang Liu
Mesenchymal stem cells (MSCs) have potential uses for cartilage repair due to the potential of chondrogenic differentiation. However, developing effective approaches to regulate chondrogenesis in vivo remains a big challenging. To address the limitations, we propose the application of magnetic fields, which features excellent performance for tissue penetration, good biocompatibility even at high magnetic strength, and wireless remote control. To test this concept, a pulsed magnetic field (PMF) was used to enhance the chondrogenesis of SPIO-labeled MSCs in a rat model of cartilage defects...
December 1, 2018: Journal of Biomedical Nanotechnology
Fashui Hong, Yingjun Zhou, Lingqun Ye, Yuguan Ze, Jianhui Ji, Juan Zhuang, Ling Wang
Nanosized titanium dioxide (Nano TiO₂) has been widely used in daily lives, medicine, industry, and caused the potential reproduction toxicity for animals and human, however, the underlying molecular mechanisms for the reproductive toxicity of nano TiO₂ are still largely unclear. In the present study, when primary cultured rat Sertoli cells (SCs) were exposed to nano TiO₂, cell injury and alterations in wingless related MMTV integration site (Wnt) pathway-related factors including Wnt1, Wnt3a, Wnt5a, Wnt11, β -catenin, and p-GSK-3 β expression were investigated...
December 1, 2018: Journal of Biomedical Nanotechnology
Qian Huang, Liying Hao, Ronghui Zhou, Bofeng Zhu, Hu Zhao, Xiaoxiao Cai
Graphitic-phase carbon nitride (g-C₃N₄) is a graphene analogue, which has attracted much attention for its unique physicochemical properties. The bulk g-C₃N₄ is often fragmented and ionized to nanosheets, obtaining improved performance or confer novel properties. It is reported that g-C₃N₄ nanosheets using different processing methods can be modified with different functional groups, resulting in different electrical characteristics. However, the surface charge of g-C₃N₄ nanosheets is seldom mentioned as a factor influencing their biological applications...
December 1, 2018: Journal of Biomedical Nanotechnology
Jixue Wang, Weiguo Xu, Shengxian Li, Heping Qiu, Zhibo Li, Chunxi Wang, Xiaoqing Wang, Jianxun Ding
For efficient therapy, optimized polymer micelle drug delivery systems require stability during circulation, appropriate diameters for targeting, and controlled drug release at the lesion site. To enhance the stability, adjust the sizes, and improve the selectivity of drug release of micelles from polylactides and polypeptides, stereocomplex interaction has been introduced. Herein, the cholesterol (CHOL)-enhanced doxorubicin (DOX)-loaded poly(D-lactide)-based micelle (CDM/DOX), poly(L-lactide)-based micelle (CLM/DOX), and stereocomplex micelle (SCM/DOX) from the equimolar mixture of the enantiomeric 4-armed poly(ethylene glycol)-polylactide copolymers were reported to enhance tumor cell uptake and control drug release for treatment of cervical carcinoma...
December 1, 2018: Journal of Biomedical Nanotechnology
Yuanyuan Xiao, Chunmei Wang, Meimei Xiong, Yuping Yang, Qianqian Zhang, Xuan Liu, Bingwen Zou, Maling Gou
Gene therapy is emerging as a promising tool for cancer treatment. Down-regulation of survivin gene can lead to the cancer inhibition. However, the lack of efficient and safe gene delivery system is still a critical obstacle to clinical gene therapy. In this study, we use a biodegradable nanoparticle to deliver human survivin-T34A ( T34A ) to dominant-negatively regulate survivin gene for ovarian cancer therapy. This nanoparticle, self-assembled from monomethoxy poly(ethylene glycol)-poly(D,L-lactide) (MPEG-PLA) copolymer and N -[1-(2,3-dioleoyloxy) propyl]- N , N , N -trimethylammonium chloride (DOTAP), has high transfection capability and negligible cytotoxicity...
December 1, 2018: Journal of Biomedical Nanotechnology
Ting Yu, Cong Wu, Changhui Zhu, Yihong He, Daoke Yang, Yongzhong Cheng, Xiang Gao
Colorectal cancer is one of the most common and malignant cancer in the world wide. Recently, combination of target therapy and chemotherapy has generated new promise for colorectal cancer. Apatinib mesylate is a novel and highly selective VEGFR-2 inhibitor, presented with an outstanding activity of anti-angiogensis, which has the potential for treating various tumors. As a traditional chemotherapeutic drug, docetaxel (Taxotere) is a widely used semisynthetic taxoid in solid tumors. In this study, Liposome and Methoxy poly(ethylene glycol)-poly( ε -caprolactone) (MPEG-PCL) were constructed as drug delivery system for the delivery of apatinib (Lipo-Apa) and docetaxel (DOC/M), respectively...
December 1, 2018: Journal of Biomedical Nanotechnology
Lixue Fan, Jiapeng Wang, Fanrong Meng, Yuan Luo, Xin Sui, Baoquan Zhao, Wanhua Li, Dongqin Quan, Jun Yang, Yongan Wang
The current clinical symptomatic therapy for Alzheimer's disease involves increasing acetylcholine levels in the brain by inhibiting acetylcholinesterase. However, the effectiveness of acetylcholinesterase inhibitors decreases as the disease progresses, leading to many side effects including over-inhibition of other enzymes and hepatic injury. Herein, we investigate the effects of the direct delivery of a low-dose of acetylcholine via human serum albumin nanoparticles to brain. This novel nanodrug improved both spatial learning and memory capability, whereas it reduced oxidative damage in mice...
December 1, 2018: Journal of Biomedical Nanotechnology
Qian Zhang, Hua Deng, Hanjun Li, Keyi Song, Cheng Zeng, Ling Rong
Graphene oxide (GO) has attracted a wide attention for its excellent mechanical, thermal properties and unique two-dimensional structure. In this work, A new GO-based supramolecular hybrid nanohydrogel was prepared, in which GO as the cross-links was incorporated into the above hydrogel through non-covalent functionalization to enhance the mechanical properties and control morphology. A 1-pyrenebutyric acid (Py) modified low-molecular weight (MW) mPEG was firstly synthesized via a simple esterification reaction...
December 1, 2018: Journal of Biomedical Nanotechnology
Yan Huang, Xiaoqiang Lü, Xiaoying Lü
The aim of this study was to screen and research key biological pathways and important microRNAs (miRNAs) involved in silver nanoparticles (SNPs) induced cytotoxicity using miRNA sequencing technology. First, the influences of five SNPs with different sizes (∼5, ∼20, ∼50, ∼100 and ∼200 nm), named as SNP-5, SNP-20, SNP-50, SNP-100, and SNP-200, on human dermal fibroblasts (HDFs) proliferation were evaluated by MTT assay after 4, 8, 12, 24, 48 and 72 h. miRNA sequencing technology was then utilized to screen differentially expressed miRNAs in SNPs treated HDFs for 4 h...
December 1, 2018: Journal of Biomedical Nanotechnology
Min Pan, Yi Zhang, Zhiting Deng, Fei Yan, Guobin Hong
Adenoviral-mediated gene therapy has been shown great prospects for tumor treatment. However, it is still a great challenge for its application in the glioma. A main cause is the blood-brain barrier (BBB) limits the delivery of adenoviral vectors, greatly compromising their efficacy. Here, we used focused ultrasound (FUS) induced microbubble cavitation to locally and reversibly open BBB for enhancing gene delivery. In this study, Ad-CMV-TK-IRES-EGFP (Ad-HSV-TK-EGFP) carrying the herpes simplex virus thymidine kinase (HSV-TK) and EGFP transgenes was chose as gendicine and Ad-CMV-IRES-EGFP (Ad-EGFP) as the control...
December 1, 2018: Journal of Biomedical Nanotechnology
Chunyan Hu, Fan Fan, Yu Qin, Chenlu Huang, Zhiming Zhang, Qing Guo, Li Zhang, Xiangbin Pang, Wenbin Ou-Yang, Kongyin Zhao, Dunwan Zhu, Linhua Zhang
We have developed redox-sensitive folic acid-conjugated PCL-PEG-PCL (PCEP) nanoparticles for co-delivering chemotherapeutic agent doxorubicin (DOX) and imaging and hyperthermia agent indocyanine green (ICG) with simultaneous imaging and combined therapy for breast cancer. DOX and ICG were entrapped into PCEP nanoparticles through the thin-film hydration and ultrasonic dispersion. Then nanoparticles were surface decorated with folic acid ligands against FR overexpressing breast cancers. Drug-loading nanoparticles exhibited an enhanced reduction-sensitivity in the presence of 10 mM glutathione...
December 1, 2018: Journal of Biomedical Nanotechnology
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