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Journal of Biomedical Nanotechnology

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https://www.readbyqxmd.com/read/30041728/fusion-of-dendritic-cells-and-cancer-associated-fibroblasts-for-activation-of-anti-tumor-cytotoxic-t-lymphocytes
#1
Liwen Qian, Zhuoran Tang, Shihua Yin, Fengzhen Mo, Xiaomei Yang, Xiaoqiong Hou, Aiqun Liu, Xiaoling Lu
Here we explored the fusion of dendritic cells (DCs), potent antigen-presenting cells that initiate primary immune responses, with cancer-associated fibroblasts (CAFs), which are a stromal component needed for tumor progression, with the aim of stimulating T cells to inhibit tumor growth. Dendritic cells from the bone marrow of BALB/c mice were co-cultured with CAFs from H22 mouse hepatoma cells. CAFs were found to express fibroblast activation protein and α-smooth muscle actin by flow cytometry, Western blotting and immunofluorescence...
October 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30041727/tumor-microenvironment-response-calcium-phosphate-hybrid-nanoparticles-enhanced-sirnas-targeting-tumors-in-vivo
#2
Zhihua Wu, Jianhua Chen, Ying Sun, Ming Shen, Lili Huang, Qing Xu, Yourong Duan, Yaogang Li
Short interfering RNA (siRNA)-based therapy has a high potential for application in cancer gene therapy. However, delivery of siRNA to target cells is limited by many factors such as serum ribonuclease (RNase) degradation, off-target effects, and inadequate cellular uptake. In this study, an enzyme-response PEG/Lipids/calcium phosphate hybrid delivery system was constructed for siRNA. The nearly neutral charged siRNA@NP2 was resistant to serum-induced degradation. Compared with the non-enzyme-response siRNA@NP1, siRNA@NP2 had efficient delivery in both SMMC-7721 cell lines and SMMC-7721-bearing nude mice...
October 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30041726/oral-delivery-of-bavachinin-loaded-peg-plga-nanoparticles-for-asthma-treatment-in-a-murine-model
#3
Kai Wang, Yupeng Feng, Shuang Li, Wenjing Li, Xi Chen, Ran Yi, Hongru Zhang, Zhangyong Hong
T helper type 2 (Th2) cytokines, such as interleukin (IL)-4, IL-5, and IL-13, are the central therapeutic targets in the development of drugs against asthma. Recently, it was found that bavachinin, an essential small molecule in Psoralea corylifolia, has very efficient therapeutic function in asthma treatment in a murine model via the selective inhibition of Th2 cytokine production. However, the clinical potential of bavachinin is limited by its extremely low water solubility (<30 ng/mL). Here, we fabricated a nanoparticle delivery system for the oral administration of bavachinin to treat asthma, with the aim of solving its administration problem...
October 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30041725/self-assembled-honokiol-loaded-microbubbles-in-the-treatment-of-ovarian-cancer-by-ultrasound-irradiation
#4
Qiong Wu, Meiqin Zhang, Hong Luo, Tao Yi
To observe the growth inhibition of subcutaneous ovarian cancer xenografts in nude mice and mechanisms by ultrasound irradiation with honokiol-loaded poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL, PCEC) microbubbles (HK-PCEC-MB) as a promising therapeutic approach to ovarian tumor. HK-PCEC-MB were prepared using the double-emulsion solvent evaporation technique. Particles were characterized with regard to shape, size, distribution and surface potential using dynamic light scattering and the Malvern Zetasizer ZS90 system...
October 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30041724/facile-gene-delivery-derived-from-branched-low-molecular-weight-polyethylenimine-by-high-efficient-chemistry
#5
Lei Zou, So Yoon Lee, Qi Wu, Haoyun Zhang, Anthony Bastian, Cara Orji, Gregory Payne, Adriana Galvez, Tima Thomas, Zijian Zhang, Huanyu Dou
Convenient methods for the preparation of gene delivery platforms based on branched low molecular weight polyethylenimine (PEI) were described. Firstly, PEI lipids, with a low molecular weight PEI headgroup and hexadecyl chain tail group, were prepared through a highly efficient ring-opening reaction of glycidyl hexadecyl ether (EpoxyC16) by amine from PEI. Then, the PEI lipids were used as a component of cationic liposomes and as a surfactant for the preparation of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticle (NP) via solvent extraction/evaporation method...
October 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30041723/salivary-analysis-based-on-surface-enhanced-raman-scattering-sensors-distinguishes-early-and-advanced-gastric-cancer-patients-from-healthy-persons
#6
Yunsheng Chen, Shangli Cheng, Aming Zhang, Jie Song, Jie Chang, Kan Wang, Yixin Zhang, Shuijun Li, Haiming Liu, Gabriel Alfranca, Muhammad Aqeel Aslam, Bingfen Chu, Can Wang, Fei Pan, Lijun Ma, Jesús M de la Fuente, Jian Ni, Daxiang Cui
Development of new methods to screen early gastric cancer patients has great clinical requirement. Ten amino acids in human saliva are identified as small metabolite biomarkers to distinguish early gastric cancer patients and advanced gastric cancer patients from healthy persons by using high performance liquid chromatography-mass spectrometry (HPLC-MS). Then, surface enhanced Raman scattering (SERS) sensors based on graphene oxide nanoscrolls wrapped with gold nanoparticles are developed to detect ten amino acids biomarkers in saliva...
October 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30041722/co-delivery-of-triptolide-and-curcumin-for-ovarian-cancer-targeting-therapy-via-mpeg-dppe-cap-nanoparticle
#7
Lei Liu, Xiaoyuan Xiong, Ming Shen, Dan Ru, Pei Gao, Xiangyu Zhang, Can Huang, Ying Sun, He Li, Yourong Duan
Triptolide has proven to possess anticancer potential and been widely used for anti-cancer research. However, the liver and kidney toxicity has limited its application in cancer treatment. In this study, a drug delivery system based on mPEG-DPPE/calcium phosphate was developed to co-load triptolide and curcumin (TP and Curc-NPs). The coefficient of drug interaction (CDI) was calculated to determine the optimal concentration of the two drugs. When the concentration of triptolide was 25.22 ng/mL and the concentration of curcumin was 6...
October 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30041721/macrophage-polarization-in-response-to-varying-pore-sizes-of-3d-polyurethane-scaffolds
#8
Ruichao Liang, Danxuan Fang, Weiwei Lin, Yanchao Wang, Zhiyong Liu, Yuelong Wang, Yunhui Zeng, Min He, Jiehua Li, Feng Luo, Jin Li, Hao Liu, Jianguo Xu, Hong Tan
Activated macrophages dominate the progression of foreign-body response (FBR) and may be in a bimodal state, which determines the fate of biomaterials postimplantation. The purpose of this study was to investigate the phenotypic profile of macrophages polarized by waterborne biodegradable polyurethane (WBPU) scaffolds with different pore diameters (PU8, PU12, and PU16) both in vitro and in vivo. The results demonstrated that WBPU scaffolds with smaller pore sizes promoted the polarization of RAW 264.7 cells towards an M1 phenotypic profile at the early stage (24 and 48 h of in vitro cultivation), indicating a pro-inflammatory response...
October 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30041720/reticuloendothelial-system-pre-block-strategy-to-improve-tumor-targeting-efficacy-for-hyaluronic-acid-related-drug-delivery-system
#9
Fulei Liu, Lingfei Han, Xiaoxian Huang, Mangmang Sang, Bowen Liu, Cong Li, Congyu Ma, Wenyuan Liu, Feng Feng, Wei Qu
Hyaluronic acid (HA) is widely used in many tumor targeting drug delivery systems (TDDS) due to its biocompatibility and modifiability. Moreover, HA receptors are over-expressed on many tumor cells. However, the clearance of the HA-related TDDS by the reticuloendothelial system (RES) need urgent consideration on account of the high affinity between HA and related receptors in RES. A pre-block strategy before TDDS administration had been designed to overcome RES clearance. In order to avoid the rapid RES clearance and further improve tumor targeting efficiency for HA-related TDDS, we designed a novel strategy of selectively pre-blocking HA receptors in RES by injecting HA-coated blank liposome (pre-block formulation) prior to dosing of HA-related TDDS...
October 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30041719/local-and-systemic-delivery-of-interleukin-12-gene-by-cationic-micelles-for-cancer-immunogene-therapy
#10
Ke Men, Rong Huang, Xueyan Zhang, Rui Zhang, Yuanfa Zhang, Mingxia He, Rongsheng Tong, Li Yang, Yuquan Wei, Xingmei Duan
Immunogene therapy is an alternative strategy for cancer gene therapy. By stimulating the activities of immune cells in the tumor microenvironment, the genetic materials boost the immune response to attack cancer cells resulting in therapeutic effects. Interleukin-12 is an important regulator with great potential in modulating both innate and adaptive immunities. Here, a cancer immunogene therapy strategy was established and evaluated by delivering the IL-12 gene with a novel non-viral gene vector DMP. The DMP cationic micelles were prepared by modifying monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) with the DOTAP lipid via self-assembly...
October 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30041718/folate-targeted-redox-responsive-polymersomes-loaded-with-chemotherapeutic-drugs-and-tariquidar-to-overcome-drug-resistance
#11
Yu Qin, Zhiming Zhang, Chenlu Huang, Fan Fan, Lanxia Liu, Li Lu, Hai Wang, Zhipeng Liu, Jun Yang, Chun Wang, Hu Yang, Hongfan Sun, Xigang Leng, Deling Kong, Linhua Zhang, Dunwan Zhu
Tumor multidrug resistance (MDR) is a fatal obstacle to cancer chemotherapy. The combination of P-glycoprotein (P-gp) inhibitor and chemotherapeutic drugs is one of the effective strategies to reverse tumor MDR. Herein, a folate-decorated PCL-ss-PEG-ss-PCL based redox-responsive polymersome (FA-TQR-Co-PS) was constructed, which was loaded with P-gp inhibitor tariquidar (TQR), anticancer drugs doxorubicin (DOX) and paclitaxel (PTX). The results suggested that the FA-TQR-Co-PS with an apparent bilayered lamellar structure displayed good monodispersity, high drug loading capacity, superior stability and redox-stimulated drug release peculiarity...
October 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30041717/gambogic-acid-loaded-polymeric-micelles-for-improved-therapeutic-effect-in-breast-cancer
#12
Yan Wang, Xiuqi Liang, Rongsheng Tong, Jin Yang, Yanxue Yang, Jian Zhong, Qinjie Wu, Changyang Gong, Jiying Yu, Lulu Cai
Gambogic acid (GA) possesses good anti-tumor efficacy in preclinical studies, however, its poor hydrophilicity, short blood circulation time and side effect limited its clinical application. In this work, monomethyl poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) copolymer was synthesized and used to encapsulate GA by a facile one-step solid dispersion and form nano-sized micelles (GA micelles). The GA micelles exhibited small average particle size (29±2 nm), high encapsulation efficiency (92.1±0.3%), and long drug release time-in vitro...
October 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30041716/molecular-imprinting-polymers-electrochemical-sensor-based-on-aunps-pth-modified-gce-for-highly-sensitive-detection-of-carcinomaembryonic-antigen
#13
Yuxuan Lai, Yan Deng, Gaojian Yang, Song Li, Chuanxiang Zhang, Xueying Liu
A novel molecular imprinted polymer (MIP) electrochemical sensor was successfully fabricated for sensitive detection of carcinomaembryonic antigen (CEA). We used CEA as template, dopamine (DA) as imprinted monomers. Through controlling electropolymerization, a "PDA-CEA"complex was achieved. After elution, the specific cavities adsorbed the target molecules. In addition, polythionine (PTh) and AuNPs were applied as the electrode modifying materials to enhance electron transfer rate and improve detection signal...
October 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30041715/effects-of-photo-activated-nanomicelles-loaded-with-fragrance-on-central-nervous-system
#14
Zhiguo Lu, Yongchang Zheng, Tianlu Zhang, Jie Shen, Zuobing Xiao, Jing Hu, Yunwei Niu, Dan Yu, Xin Zhang
Many kinds of fragrances have the effects on life cultivation and health preservation. These fragrances can be used for emotional regulation, partly because of the way it can modulate our central nervous system (CNS), further affect our moods and even improve our behaviour. But the effects are very dependent on their concentrations in the air. In this study, photo-responsive micelles named as PPMM-PEG@S803 were designed and prepared to encapsulate and controllably release sandela 803. PPMM-PEG@S803 was then applied to wallpaper (PPMM-PEG-W@S803) and the effects of this treated wallpaper on CNS of mice were evaluated...
October 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29958560/immunosuppressive-effect-of-ticagrelor-on-dendritic-cell-function-a-new-therapeutic-target-of-antiplatelet-agents-in-cardiovascular-disease
#15
Lizhen Liao, Yue Guo, Xiaodong Zhuang, Weidong Li, Jing Zou, Qibiao Su, Jie Zhao, Ying Liu, Xinxue Liao, Zhimin Du, Xun Hu
Atherosclerosis is being thought of as an autoimmune disease. As the most potent antigen-presenting cells, dendritic cells (DCs) have been regarded as a major target for the control of this harmful immune response. In this study, we investigated the effect of ticagrelor, a new antiplatelet drug antagonizing the P2Y12 receptor, on the function of mouse bone marrow-derived DCs. RT-PCR revealed relatively high P2Y12 mRNA levels in DCs, and expression of the P2Y12 protein was documented by western blot analysis...
September 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29958559/transfection-of-difficult-to-transfect-rat-primary-cortical-neurons-with-magnetic-nanoparticles
#16
Wuyang Jin, Donghai Lin, Anh H Nguyen, Gaser N Abdelrasoul, Jian Chen, Arthur Mar, Feng Qian, Qiang Fang, Igor Kovalchuk, Yutian Wang, Jie Chen
The efficient cell transfection method is vital for various biomedical applications, such as the CRISPR-Cas9 technique. Current cell transfection methods, including lipofectamine, calcium phosphate co-precipitation, nucleofection, and viral infection are not equally efficient for various cells and have their disadvantages. In this study, a magnetic nanoparticle (MNP)-based method was introduced for delivering both FITC dye and a functional EGFP gene into easy-to-transfect HEK cells and difficult-to-transfect rat primary cortical neurons...
September 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29958558/tls11a-aptamer-cd3-antibody-anti-tumor-system-for-liver-cancer
#17
Zixi Hu, Jian He, Wenlin Gong, Nuo Zhou, Sufang Zhou, Zongqiang Lai, Rong Zheng, Yiwei Wang, Xiaomei Yang, Wei Yang, Liping Zhong, Xiaoling Lu, Yongxiang Zhao
New therapeutic approaches are needed for hepatocellular carcinoma (HCC), which is the most common primary malignancy of the liver. Bispecific T-cell engagers (BiTE) can effectively redirect T cells against tumors and show a strong anti-tumor effect. However, the potential immunogenicity, complexity, and high cost significantly limit their clinical application. In this paper, we used the hepatoma cells-specific aptamer TLS11a and anti-CD3 for to establish an aptamer/antibody bispecific system (AAbs), TLS11a/CD3, which showed advantages over BiTE and can specifically redirect T cells to lyse tumor cells...
September 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29958557/novel-carbon-dots-derived-from-cirsii-japonici-herba-carbonisata-and-their-haemostatic-effect
#18
Yongzhi Wang, Hui Kong, Xiaoman Liu, Juan Luo, Wei Xiong, Yafan Zhu, Yaxue Zhang, Yihe Zhang, Yan Zhao, Huihua Qu
The purpose of this study was to explore the haemostatic effect of novel carbon dots (CDs) derived from Cirsii Japonici Herba Carbonisata (CJHC). Transmission electron microscopy (TEM), high-resolution TEM, Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, fluorescence spectroscopy, X-ray photoelectron spectroscopy, high performance liquid chromatography and a cell counting kit-8 assay of CJHC-CDs were performed. Then the haemostatic effect of this CJHC-CDs was studied in bleeding mouse models...
September 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29958556/nitrogen-incorporated-ultrananocrystalline-diamond-electrodes-for-dopamine-determination
#19
Pei-Ling Jiang, Ping-Yen Hsieh, Ying-Chieh Chen, Chi-Young Lee, Hwan-You Chang, Nyan-Hwa Tai
In this paper, nitrogen incorporated ultrananocrystalline diamond (NUNCD) films were fabricated for use as electrodes to detect dopamine. The NUNCD electrodes achieved high sensitivity, great selectivity, and excellent detection limits for dopamine sensing. The NUNCD electrode, fabricated as a potential sensitive biosensor for dopamine without any catalyst or mediators, demonstrated good activity for the direct detection of dopamine by simply putting the bare NUNCD electrode into a dopamine solution. Furthermore, the marked selectivity of the NUNCD electrode is very favorable for the determination of dopamine (DA) concentration (0...
September 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29958555/functionalized-multi-walled-carbon-nanotubes-for-targeting-delivery-of-immunostimulatory-cpg-oligonucleotides-against-prostate-cancer
#20
Qingming Xia, Chunai Gong, Fenfen Gu, Zhuo Wang, Chuling Hu, Lijuan Zhang, Lei Qiang, Xueying Ding, Shen Gao, Yuan Gao
Immuno-based oncotherapy has been successfully implemented for cancer treatment. In the present study, we developed a Oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs (CpG ODNs) nano-delivery system based on Multi-walled carbon nanotubes (MWCNTs) conjugated with H3R6 polypeptide (MHR-CpG) for prostate cancer immunotherapy. The in vitro and in vivo toxicity data revealed that the prepared MHR showed high biocompatibility. Confocal laser scanning microscopy confirmed that MHR-CpG could specifically target the endosomal TLR9...
September 1, 2018: Journal of Biomedical Nanotechnology
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