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Journal of Biomedical Nanotechnology

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https://www.readbyqxmd.com/read/30480528/erratum-mechanism-of-nanotization-mediated-improvement-in-the-efficacy-of-caffeine-against-1-methyl-4-phenyl-1-2-3-6-tetrahydropyridine-induced-parkinsonism-journal-of-biomedical-nanotechnology-vol-11-12-pp-2211-2222-2015
#1
Naveen Kumar Singhal, Swati Agarwal, Priyanka Bhatnagar, Manindra Nath Tiwari, Shashi Kant Tiwari, Garima Srivastava, Pradeep Kumar, Brashket Seth, Devendra Kumar Patel, Rajnish Kumar Chaturvedi, Mahendra Pratap Singh, Kailash Chand Gupta
No abstract text is available yet for this article.
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480527/a-novel-peptide-aptamer-to-detect-plasmodium-falciparum-lactate-dehydrogenase
#2
Dong-Xu Liu, Trinh Thi Thuy Tien, Duong Tuan Bao, Nguyen Thi Phuong Linh, Hyun Park, Seon-Ju Yeo
Alternative antibody (aptamer)-based biosensors are attracting increasing attention owing to advantages such as simplicity and low cost, which are beneficial for point-of-care diagnosis, particularly where resources are limited. In this study based on in silico modeling predictions made with Autodock Vina, the binding affinity of an optimized novel peptide (Pf_P1: KITTTDEEVEGIFD) was altered compared to that of the original epitope peptide (P1: KITDEEVEGIFDC). The binding energy of Pf_P1 implies that it has stronger interactions with Plasmodium falciparum lactate dehydrogenase (LDH) than with human LDH...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480526/ciliary-mechanism-of-regulating-hedgehog-and-wnt-%C3%AE-catenin-signaling-modulates-ultraviolet-b-irradiation-induced-photodamage-in-hacat-cells
#3
Tianding Shen, Kai Gao, Zhiqi Hu, Yong Miao, Xue Wang
Skin undergoes photoaging, typically characterized by UV-damage lesions with matrix degradation and inflammatory changes. This process involves Hedgehog (Hh) signaling and the canonical Wnt pathway. Recently, primary cilia-microtubule-based organelles-have been implicated in the transduction of Hh and Wnt signaling. However, their role in photoaging remained unclear. In this study, we have shown that UVB causes both upregulation of MMPs and proinflammatory cytokines, as well as cilia formation in HaCaT cells, and that these changes can be attenuated by ciliogenesis inhibitor HPI-4 and anti-inflammatory PD98059 treatment...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480525/co-delivery-of-rose-bengal-and-doxorubicin-nanoparticles-for-combination-photodynamic-and-chemo-therapy
#4
Xueqiong Zhang, Lianghong Li, Qi Liu, Yaowen Wang, Jianguang Yang, Tong Qiu, Gang Zhou
Carboxymethyl chitosan (CMCS) is applied as a nanodelivery system carrier for sustained intracellular release of rose bengal (RB) and doxorubicin (DOX) to achieve combinational drug treatments. An integral analytical method was used to characterize the structure of CMCS-RB, the amount of RB and DOX, the average particle size, the zeta potential, and the morphology, including Fourier transform infrared (FTIR), nuclear magnetic resonance (1 H NMR), ultraviolet visible spectroscopy (UV-Vis), scanning electron microscope (SEM), laser particle size analyzer and transmission electron microscopy (TEM)...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480524/changing-the-way-of-entrance-highly-efficient-transfer-of-mrna-and-sirna-via-fusogenic-nano-carriers
#5
Marco Hoffmann, Nils Hersch, Rudolf Merkel, Agnes Csiszar, Bernd Hoffmann
Transferring nucleic acids into mammalian cells heavily influences life science for decades. While first applications mainly dealt with DNA transfer for various purposes as e.g., plasmid encoded protein expression or generation of mutant strains, subsequent applications additionally transferred RNA molecules of mainly small lengths for specific knockdown (RNAi) or site-specific genome modification (gRNA). Significant improvements in full length mRNA generation and extension of mRNA lifetimes additionally allows their use for transient expression in latest times...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480523/modeling-and-bias-robust-estimation-of-the-acoustic-release-of-chemotherapeutics-from-liposomes
#6
Ali Wadi, Mamoun Abdel-Hafez, Ghaleb A Husseini
This paper models the acoustic drug release of chemotherapeutics from liposomes using a kinetic model that accounts for systematic biases affecting the drug delivery process. An optimal stochastic filter is then proposed to provide robust estimates of the percent drug released. Optimality is guaranteed by accurately identifying the underlying statistical noise characteristics in experimental data. The estimator also quantifies the bias in the release, exhibited by the experimental data. Drug release is experimentally measured as a change in fluorescence upon the application of ultrasound...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480522/novel-carbon-dots-derived-from-radix-puerariae-carbonisata-significantly-improve-the-solubility-and-bioavailability-of-baicalin
#7
Juan Luo, Hui Kong, Meiling Zhang, Jinjun Cheng, Ziwei Sun, Wei Xiong, Yafan Zhu, Yan Zhao, Huihua Qu
Baicalin (BA) has gained considerable attention in recent years for its multiple pharmacological activities. However, its optimum pharmaceutical potential has been limited by its poor solubility in water. In this study, for the first time, we discovered that novel water-soluble carbon dots (CDs, named RPC-CDs) from aqueous extracts of Radix Puerariae Carbonisata (RPC). The chemical composition and morphological features of the RPC-CDs we obtained were characterized using various spectroscopies and transmission electron microscopy and the CDs have a low toxicity against RAW 264...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480521/multiwalled-carbon-nanotubes-prevent-tumor-metastasis-through-switching-m2-polarized-macrophages-to-m1-via-tlr4-activation
#8
Lianlian Wu, Hongling Tang, Hao Zheng, Xiaoxiao Liu, Yanzhuo Liu, Jing Tao, Zhengyan Liang, Yuqi Xia, Yang Xu, Yong Guo, Honglei Chen, Jing Yang
Targeting tumor-associated macrophages (TAMs) has emerged as a novel therapeutic strategy for cancer metastasis. Here, we investigated whether carboxylated multiwalled carbon nanotubes (MWCNTs-COOH) prevent tumor metastasis through regulating macrophage polarization. In Lewis lung carcinoma (LLC) or B16F10 melanoma-bearing mice, intratracheal instillation of MWCNTs-COOH significantly reduced metastatic burden in the lungs. MWCNTs-COOH promoted the expression of M1 markers (iNOS and CXCR10) and inhibited the expression of M2 markers (CD206 and Arg-1) along with an increased expression of Th1 cytokines (TNF- α and IL-12) and decreased expression of Th2 cytokines (TGF- β and IL-10)...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480520/hyaluronic-acid-functionalized-gadolinium-doped-iron-oxide-nanoparticles-for-atherosclerosis-targeted-mr-imaging
#9
Ming Yu, Yuanyuan Niu, Dan Zhou, Rong Jiang, Lirong Zhang, Huixiang Ju, Aihua Gong, Shenqiang Zou, Miaomiao Zhang, Fengyi Du
Magnetic resonance imaging (MRI) contrast agents (CTs) with both positive ( T 1 ) and negative ( T ₂) contrast abilities have attracted considerable interests due to their complementary diagnostic information for more precise diagnosis. In this study, gadolinium-doped oxide nanoparticles functionalized by hyaluronic acid (HA-GdIO NPs) were synthesized for atherosclerosis-targeting T 1 - T ₂ dual-model MR imaging. The results showed that the HA-GdIO NPs exhibited high magnetic susceptibility and good biocompatibility...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480519/co-delivery-of-runx2-targeting-mirnas-and-shrnas-using-nanoparticles-composed-of-dexamethasone-and-pei-induces-chondrogenesis-of-human-mesenchymal-stem-cells
#10
Seong Min Kim, Se Won Yi, Hye Jin Kim, Ji Sun Park, Jae-Hwan Kim, Keun-Hong Park
RNA interference (RNAi) plays important roles, and microRNAs (miRNAs) are used as biomarkers and targets in cell therapies. In this study, we fabricated miRNAs and short hairpin RNAs (shRNAs) targeting the osteogenic RUNX2 gene to induce chondrogenesis of human mesenchymal stem cells (hMSCs). pDNA harboring these miRNAs and shRNAs was complexed with nanoparticles composed of dexamethasone and tetramethlyrhodamine-labeled branched polyethyleneimine (RDtNPs). The miRNAs and shRNAs reduced RUNX2 expression in hMSCs at early (12 h) and late (72 h) time points, respectively...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480518/real-time-imaging-tracking-of-a-dual-fluorescent-vaccine-delivery-system-based-on-ovalbumin-loaded-zinc-phthalocyanine-incorporated-copolymer-nanoparticles
#11
Chang Wei, Xia Dong, Jie Liang, Yan Zhang, Dunwan Zhu, Deling Kong, Feng Lv
The vaccine delivery process plays a significant role for antigen-specific immune responses, which directly determines the effect of immunotherapy. It is crucial to reveal the real-time process of the vaccine release and the status of the implanted carrier in vivo . Herein, a dual fluorescent vaccine delivery system was monitored with the rhodamine-ovalbumin loaded zinc phthalocyanine conjugated nanoparticles (PHA-OVA NPs) to explore the vaccine delivery process. The PHA-OVA NPs showed a sustained release of ovalbumin in vitro and could significantly enhance the uptake of antigen by dendritic cells (DCs)...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480517/a-synergistically-enhanced-t-1-and-t%C3%A2-weighted-magnetic-resonance-near-infrared-contrast-agent-of-gd-doping-fe%C3%A2-o%C3%A2-fluorescence-pegylated-nanoparticles-for-multimodality-imaging-of-hepatocarcinoma
#12
Yankun Li, Dan Li, Kang Jian, Xifan Mei, Guannan Wang
In recent years, multimodal imaging nanoprobes with high resolution and high sensitivity capabilities have attracted considerable interest because they could offer complementary diagnostic information that would lead to a more precise diagnosis. Herein, the facile fabrication of Gd-doping magnetic nanoparticles conjugated with the PEGylated fluorescence probe Cy5.5 and the tumor-penetrating peptide RGERPPR (R) has been demonstrated for tri-modality targeted T1 and T₂-weighted magnetic resonance (MR) and the near-infrared (NIR) fluorescence imaging of hepatocarcinoma-bearing mice...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480516/electrospun-bilayer-composite-vascular-graft-with-an-inner-layer-modified-by-polyethylene-glycol-and-haparin-to-regenerate-the-blood-vessel
#13
Haizhu Kuang, Shuofei Yang, Yao Wang, Yuting He, Kaiqiang Ye, Junfeng Hu, Wei Shen, Yosry Morsi, Shuyang Lu, Xiumei Mo
In this study, we prepared a composite vascular graft with two layers. The inner layer, which was comprised of degradable Poly(lactic-co-glycolic acid) (PLGA)/Collagen (PC) nanofibers modified by mesoporous silica nanoparticles (MSN), was grafted with polyethylene glycol (PEG) and heparin to promote cell proliferation and to improve blood compatibility. The outer layer was comprised of polyurethane (PU) nanofibers in order to provide mechanical support. The growth and proliferation of human umbilical vein endothelial cells (HUVECs) in the inner layer was significant, and blood compatibility testing showed that the inner layer had good blood compatibility...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480515/naturally-derived-pha-l-protein-nanoparticle-as-a-radioprotector-through-activation-of-toll-like-receptor-5
#14
Wei Long, Junying Wang, Jiang Yang, Hongying Wu, Jingya Wang, Xiaoyu Mu, Hua He, Qiang Liu, Yuan-Ming Sun, Haichao Wang, Xiao-Dong Zhang
High energy ray in medical diagnosis and therapy can benefit to patients, but can also cause the significant damages to biomolecules such as DNA, as well as free radical generation, inevitably leading to numerous side effects. Small molecular radioprotectors provide an effective route to preserve the healthy tissue and whole body from ionizing radiation, but always have a short circulation time in body. Inorganic nanoparticles show major protection effect but their heavy metal components considerably jeopardize translational promise due to suboptimal biocompatibility...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480514/folate-modified-liposomes-loaded-with-telmisartan-enhance-anti-atherosclerotic-potency-for-advanced-atherosclerosis-in-apoe-mice
#15
Dailong Fang, Quansheng Jin, Zhaohui Jin, Fazhan Wang, Lingjing Huang, Yuhan Yang, Zhiyao He, Yongmei Liu, Chunling Jiang, Jinhui Wu, Xiangrong Song
For the effective inhibition of atherosclerotic plaque rupture, there is an urgent need to develop a carrier which can specifically deliver the therapeutic agents to atherosclerotic lesions. Since the representative hallmark of plaques in advanced atherosclerosis is the large number of macrophages which highly upregulate folate receptor beta (FR- β ), we herein investigated the potential of folate-modified liposomes (FA-P-LP) as the carrier for active targeting of atherosclerotic plaques. In vitro cellular uptake tests, FA-P-LP exhibited an enhanced uptake in activated RAW264...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480513/enhanced-endocytic-and-ph-sensitive-poly-malic-acid-micelles-for-antitumor-drug-delivery
#16
Youbei Qiao, Chaoli Wang, Bao Liu, Yifan Peng, Hao Meng, Tiehong Yang, Qing Zhou, Songyan Guo, Hong Wu
Poly( β -benzyl malate) (PBM), a derivative of poly( β -malic acid) (PMLA), is a potential antitumor drug carrier due to its desirable biocompatibility and nontoxicity. In this study, micelles based on PBM-PEG polymers were prepared, which possessed several key features, including (i) micelle formation via self-assembly with a size of approximately 100 nm, (ii) π - π stacking interactions between the polymer chains and between the polymer and the drug, improving the stability of micelles and drug loading capacity (drug loading rate increased to 20 wt%), (iii) the cell penetrating peptide (TAT) was shielded by a long PEG chain before reaching the tumor site and exposed to tumor tissue, and (iv) high efficiency tumor uptake via exposure to TAT...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30480512/nanoparticle-based-drug-delivery-systems-for-enhanced-tumor-targeting-treatment
#17
Yanan Li, Hui Zhang
The encapsulation of targeting agents into nanoscale drug delivery systems (DDS) for cancer therapy has received considerable attention in recent years. The thriving area of cancer nanotechnology provides a unique and comprehensive anticancer approach through early diagnosis, prediction, prevention, and personalized medical therapy, preferentially vital in target-specific drug curative strategies. In this review, the concept of cancer nanotechnology and its areas of specialty are introduced, followed by a detailed presentation of specific targeting methods and various nanoparticle (NP) drug delivery systems...
January 1, 2019: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30305229/author-index-to-volume-14-numbers-1-12-2018
#18
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30305228/table-of-contents-to-volume-14-numbers-1-12-2018
#19
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/30305227/magnolol-nanoparticles-exhibit-improved-water-solubility-and-suppress-tnf-%C3%AE-induced-vcam-1-expression-in-endothelial-cells-journal-of-biomedical-nanotechnology-vol-13-3-pp-255-268-2017
#20
Chiang-Wen Lee, Stephen Chu-Sung Hu, Feng-Lin Yen, Lee-Fen Hsu, I-Ta Lee, Zih-Chan Lin, Ming-Horng Tsai, Chieh-Liang Huang, Chan-Jung Liang, Yao-Chang Chiang
No abstract text is available yet for this article.
December 1, 2018: Journal of Biomedical Nanotechnology
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