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Journal of Biomedical Nanotechnology

Didier Dréau, Laura Jeffords Moore, Merlis P Alvarez-Berrios, Mubin Tarannum, Pinku Mukherjee, Juan L Vivero-Escoto
Mucin-1 (MUC1), a transmembrane glycoprotein is aberrantly expressed on ~90% of breast cancer and is an excellent target for nanoparticulate targeted imaging. In this study, the development of a dye-doped NIR emitting mesoporous silica nanoparticles platform conjugated to tumor-specific MUC1 antibody (ab-tMUC1-NIR-MSN) for in vivo optical detection of breast adenocarcinoma tissue is reported. The structural properties, the in vitro and in vivo performance of this nanoparticle-based probe were evaluated. In vitro studies showed that the MSN-based optical imaging nanoprobe is non-cytotoxic and targets efficiently mammary cancer cells overexpressing human tMUC1 protein...
December 2016: Journal of Biomedical Nanotechnology
Salik Hussain, Preeti P Kodavanti, Jamie D Marshburn, Agnes Janoshazi, Stella M Marinakos, Margaret George, Annette Rice, Mark R Wiesner, Stavros Garantziotis
Cerium dioxide nanoparticles (nanoceria), currently used as catalysts including additives to diesel fuel, also present potential as a novel therapeutic agent for disorders involving oxidative stress. However, little is known about the effects of nanoceria on primary human cells involved in the innate immune response. Here, we evaluate nanoceria effects on monocyte derived macrophages (MDMs) from healthy human subjects. Peripheral blood monocytes were isolated from healthy human volunteers. MDMs were obtained by maturing monocytes over a five-day period...
December 2016: Journal of Biomedical Nanotechnology
M Ingmar van Raath, Ruud Weijer, Gia Hung Nguyen, Bernard Choi, Anton I de Kroon, Michal Heger
Site-specific pharmaco-laser therapy (SSPLT) is a developmental stage treatment modality designed to non-invasively remove superficial vascular pathologies such as port wine stains (PWS) by combining conventional laser therapy with the prior administration of a prothrombotic and/or antifibrinolytic pharmaceutical-containing drug delivery system. For the antifibrinolytic SSPLT component, six different PEGylated thermosensitive liposomal formulations encapsulating tranexamic acid (TA), a potent antifibrinolytic lysine analogue, were characterized for drug:lipid ratio, encapsulation efficiency, size, endovesicular TA concentration (CTA), phase transition temperature (Tm), and assayed for heat-induced TA release...
August 2016: Journal of Biomedical Nanotechnology
Jun Zhou, Hong Weng, Yihui Huang, Yueqing Gu, Liping Tang, Wenjing Hu
Release of reactive oxygen species (ROS) accompanied with acute inflammation and infection often results in cell death and tissue injury. Several ROS-reactive bioluminescent probes have been investigated in recent years to detect ROS activity in vivo. Unfortunately, these probes cannot be used to quantify the degree of ROS activity and inflammatory responses due to the fact that the extent of the bioluminescent signals is also probe-concentration dependent. To address this challenge, we fabricated a ratiometric ROS probe in which both ROS-sensitive chemiluminescent agents and ROS-insensitive fluorescent reference dye were conjugated to particle carriers...
August 2016: Journal of Biomedical Nanotechnology
Liangli Cao, Yongbo Liang, Feijun Zhao, Xiongjie Zhao, Zhencheng Chen
The work focused on manufacturing improved drug loaded multifunctional magnetic nanoparticles that can overcome the relative non-specificity and potential side-effects of some chemotherapeutic drugs to healthy tissues. A new drug delivery system, Chelerythrine (CHE) and Fe3O4 loaded multi-walled carbon nanotubes (Fe3O4/MWNTs-CHE nanocomposites) that can target hepatocytes when treating malignant tumors, was prepared through a simple adsorption method. The formulation and structure of the Fe3O4/MWNTs-CHE nanocomposites were characterized by vibrating sample magnetometer (VSM), Fourier Transform infrared spectroscopy (FTIR) and Scanning Electron Microscopy (SEM)...
June 2016: Journal of Biomedical Nanotechnology
Julia E Vela Ramirez, Lorraine T Tygrett, Jihua Hao, Habtom H Habte, Michael W Cho, Neil S Greenspan, Thomas J Waldschmidt, Balaji Narasimhan
Biodegradable polymeric nanoparticle-based subunit vaccines have shown promising characteristics by enhancing antigen presentation and inducing protective immune responses when compared with soluble protein. Specifically, polyanhydride nanoparticle-based vaccines (i.e., nanovaccines) have been shown to successfully encapsulate and release antigens, activate B and T cells, and induce both antibody- and cell-mediated immunity towards a variety of immunogens. One of the characteristics of strong thymus-dependent antibody responses is the formation of germinal centers (GC) and the generation of GC B cells, which is part of the T helper cell driven cellular response...
June 2016: Journal of Biomedical Nanotechnology
Oliver Jonas, David Calligaris, Kashi Reddy Methuku, Michael M Poe, Jessica Pierre Francois, Frank Tranghese, Armen Changelian, Werner Sieghart, Margot Ernst, Daniel A Pomeranz Krummel, James M Cook, Scott L Pomeroy, Michael Cima, Nathalie Y R Agar, Robert Langer, Soma Sengupta
Medulloblastoma is the most common childhood malignant brain tumor. The most lethal medulloblastoma subtype exhibits a high expression of the GABAA receptor α5 subunit gene and MYC amplification. New benzodiazepines have been synthesized to function as α5-GABAA receptor ligands. To compare their efficacy with that of standard-of-care treatments, we have employed a newly developed microscale implantable device that allows for high-throughput localized intratumor drug delivery and efficacy testing. Microdoses of each drug were delivered into small distinct regions of tumors, as confirmed by tissue mass spectrometry, and the local drug effect was determined by immunohistochemistry...
June 2016: Journal of Biomedical Nanotechnology
Xia Zhao, David E Komatsu, Michael Hadjiargyrou
The development of effective strategies for gene delivery is a critical goal in DNA-based tissue engineering. Previously, our laboratory utilized the process of electrospinning to fabricate plasmid DNA-based polymeric scaffolds. Although there lease of DNA was robust, the in vitro transfection efficiency was low. In order to optimize these results, we recently modified our approach and utilized a strategy to adsorb plasmid DNA transfection complexes onto a PLLA/Collagen I electrospun scaffold for the delivery of recombinant human Bone Morphogenetic Protein-2 (rhBMP-2)...
June 2016: Journal of Biomedical Nanotechnology
Yunsong Liu, Tong Chen, Feng Du, Ming Gu, Ping Zhang, Xiao Zhang, Jianzhang Liu, Longwei Lv, Chunyang Xiong, Yongsheng Zhou
In recent years, although several studies have demonstrated the potential of graphene-coated substrates in promoting attachment, proliferation and differentiation of osteoblasts and mesenchymal stem cells (MSCs), the effects of single-layer graphene on the osteogenic differentiation of human MSCs (hMSCs) remains unclear, especially in vivo. In this study, we transferred chemical vapor deposition (CVD) grown single-layer graphene to glass slides and observed its effects on adhesion, proliferation and osteogenic differentiation of human adipose-derived stem cells (hASCs) and human bone marrow mesenchymal stem cells (hBMMSCs) in vitro...
June 2016: Journal of Biomedical Nanotechnology
Hao Li, Xian Li, Chao Zhang, Qiquan Sun, Wei Yi, Xuan Wang, Du Cheng, Shupeng Chen, Biling Liang, Xintao Shuai
A diblock copolymer of poly(ethylene glycol) (PEG) and poly(γ-benzyl L-glutamate) (PBLG), PEG-PBLG, was synthesized via the ring-opening polymerization of γ-benzyl L-glutamate N-carboxyanhydride (BLG-NCA) using allyl-PEG-NH2 as a macroinitiator. After deprotection of the benzyl groups, N,N-diisopropyl ethylenediamine (DIP) was conjugated to poly(L-glutamic acid) (PGA) blocks as side groups. The pendant DIP groups on the PGA blocks greatly enhance the pH-sensitivity of poly(ethylene glycol)-block-poly[N-(N',N'-diisopropylaminoethyl) glutamide] [PEG-PGA(DIP)] micelles, and a higher grafting percentage of DIP favors a faster acid-response...
June 2016: Journal of Biomedical Nanotechnology
Yinmei Dong, Huaiwen Chen, Chao Chen, Xuefeng Zhang, Xia Tian, Yingying Zhang, Zhang Shi, Qi Liu
Magnetic resonance imaging (MRI) combined with ultrasmall superparamagnetic iron oxide (USPIO) is effective for the detection of atherosclerotic (AS) plaque, and paclitaxel is effective for the treatment of AS. C11 is a polypeptide with high affinity and specificity for collagen IV. It is abundantly expressed in the outer layer of AS plaque. This study aimed to develop USPIO + paclitaxel-loaded polymer-lipid hybrid theranostic nanoparticles conjugated with C11 (UP-NP-C11) for simultaneous imaging and treatment AS plaque...
June 2016: Journal of Biomedical Nanotechnology
Junjiang Jin, Ying Dong, Ying Wang, Lin Xia, Weihong Gu, Xue Bai, Yanan Chang, Mingyi Zhang, Kui Chen, Juan Li, Lina Zhao, Gengmei Xing
Fullerenol nanoparticles are promising for various biological applications; many studies have shown that they induce variable and diverse biological effects including side effects. Separation and purification of two fractions of fullerenols has demonstrated that they have varied chemical structures on the surfaces of their carbon cages. Actin is an important structural protein that is able to transform functional structures under varied physiological conditions. We assessed the abilities of the two fractions of fullerenols to attach to actin and induce variable morphological features in actin filament structures...
June 2016: Journal of Biomedical Nanotechnology
Lanxia Liu, Guilei Ma, Chao Zhang, Hai Wang, Hongfan Sun, Chun Wang, Cunxian Song, Deling Kong
Self-quenchable indocyanine green (ICG)-encapsulated micelles with folic acid (FA)-targeting specificity (FA-ICG-micelles) were developed for biologically activatable photodynamic theranostics. FA-ICG-micelles were successfully prepared using the thin-film hydration method, which allows ICG to be encapsulated with a high drug loading that induces an efficient ICG-based quenched state. FA-ICG-micelles are initially in the "OFF" state with no fluorescence signal or phototoxicity, but they become highly fluorescent and phototoxic in cellular degradative environments...
June 2016: Journal of Biomedical Nanotechnology
Hui-Lian Che, In-Hi Bae, Kyung Seob Lim, In Taek Song, Haeshin Lee, Duhwan Lee, Won Jong Kim, Myung-Ho Jeong, Youngkeun Ahn
For effective treatment of restenosis, therapeutic genes are delivered locally from a coated stent at the site of injury, leading to inhibition of smooth muscle proliferation and neo-intimal hyperplasia while promoting re-endothelialization. In a previous study, we delivered Akt1 siRNA nanoparticles (ASNs) from a hyaluronic acid (HA)-coated stent surface to specifically suppress the pro-proliferative Akt1 protein in smooth muscle cells (SMCs). In the present study, therapeutic efficacy was investigated in a rabbit restenosis model after percutaneous implantation of an ASN-immobilized stent in a rabbit iliac artery...
June 2016: Journal of Biomedical Nanotechnology
Zhi Dai, Ying Tu, Lin Zhu
Poor water solubility, low tumor specificity, insufficient cell internalization, and drug resistance are typical among chemotherapy drugs. In this study, the multifunctional micellar nanocarriers containing the PEG2k-pp-PE, a matrix metalloproteinase 2 (MMP2)-labile self-assembling block copolymer, and the TAT-PEG1k-PE, a cell penetrating moiety, were developed for tumor-targeted delivery of hydrophobic drugs. The functional polymers and their nanocarriers were characterized in terms of their size, zeta potential, micelle formation capability, drug loading and release, cellular uptake, and anticancer activity...
June 2016: Journal of Biomedical Nanotechnology
Wei Gao, Xiucong Yang, Zhiqiang Lin, Shanyun Gao, Bing He, Bong Mei, Dan Wang, Lan Yuan, Hua Zhang, Wenbing Dai, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Qiang Zhang
In addition to showing the specific interaction between a generalized ligand and its receptor and the electrostatic effect between positive cell-penetrating peptides and negative cell membranes, our last study demonstrated the hydrophobic interactivity between a hydrophobic binding peptide (HBP) and biomembranes to be favorable in drug delivery. To yield more evidence for this new strategy and to find more effective HBPs, here we designed and established a novel nanomedicine associated with cyclosporin A (CsA) because this peptide is electrically neutral, highly hydrophobic, very stable in vivo and safe at the given dose...
June 2016: Journal of Biomedical Nanotechnology
Rong Chen, Hui Yu, Yan-Li An, Hua-Jun Chen, ZhenYu Jia, Gao-Jun Teng
Transplantation of gene transfected endothelial progenitor cells (EPCs) provides a novel method for treatment of human tumors. To study treatment of hepatocellular carcinoma using cytosine deaminase (CD)- and endostatin (ES)-transfected endothelial progenitor cells (EPCs), mouse bone marrow-derived EPCs were cultured and transfected with Lenti6.3-CD-EGFP and Lenti6.3-ES-Monomer-DsRed labeled with superparamagnetic iron oxide (SPIO) nanoparticles. DiD (lipophilic fluorescent dye)-labeled EPCs were injected into normal mice and mice with liver carcinoma...
June 2016: Journal of Biomedical Nanotechnology
Akhil Srivastava, Anish Babu, Justyna Filant, Katherine M Moxley, Rachel Ruskin, Danny Dhanasekaran, Anil K Sood, Scott McMeekin, Rajagopal Ramesh
The bottleneck in current vector-based cancer therapy is the targeted and controlled release of therapeutics in tumors. Exosomes are submicron-sized vesicles that are secreted by all cell types and are involved in communication and transportation of materials between cells. Analogous in size and function to synthetic nanoparticles, exosomes offer many advantages, rendering them the most promising candidates for targeted drug or gene delivery vehicles. Patient-specific customized therapeutic strategies can be engineered using exosomes derived from the patient's own healthy cells...
June 2016: Journal of Biomedical Nanotechnology
Valeria S Marangoni, Juliana Cancino-Bernardi, Valtencir Zucolotto
The development of new systems for diagnostic and therapeutic applications is a topic of intense and growing interest. The unique optical and electronic properties exhibited by gold-based nanomaterials have proved to be valuable for a wide range of biomedical applications. Recently, great attention has been given to rod-shaped gold nanomaterials, especially because of their electronic absorption band in the near infrared region, where maximum radiation penetration through tissue occurs. This feature has allowed the use of gold nanorods for in vivo imaging, with different techniques, and photothermal therapy...
June 2016: Journal of Biomedical Nanotechnology
Yanli Wang, Chenchen Li, Chenjie Yao, Lin Ding, Zhendong Lei, Minghong Wu
Nanotechnology has been a rapidly developing field in the past few decades, resulting in the more and more exposure of nanomaterials to human. The increased applications of nanomaterials for industrial, commercial and life purposes, such as fillers, catalysts, semiconductors, paints, cosmetic additives and drug carriers, have caused both obvious and potential impacts on human health and environment. Nanotoxicology is used to study the safety of nanomaterials and has grown at the historic moment. Molecular toxicology is a new subdiscipline to study the interactions and impacts of materials at the molecular level...
June 2016: Journal of Biomedical Nanotechnology
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