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Journal of Biomedical Nanotechnology

Ondrej Svoboda, Zdenka Fohlerova, Larisa Baiazitova, Petr Mlynek, Konstantin Samouylov, Ivo Provaznik, Jaromir Hubalek
A non-viral tool for the delivery of nucleic acids termed magnetofection was recently developed as a promising transgenic technique with high transfection efficiency for gene delivery into mammalian cells. Despite the fact that transfection efficiency was the objective in the past, the post-transfection cell morphology and the essential gigaseal formation between cells and patch clamp glass electrodes have not been studied in detail. The cell viability and fluorescent response of Accelerated Sensor of Action Potentials (ASAP1) were studied in somatic HEK293 cells with respect to preserving physiological cell behavior and morphology...
August 1, 2018: Journal of Biomedical Nanotechnology
Yiwen Liu, Jine Li, Juanxia Wu, Fan Ping, Lingling Xu, Qi Sun, Ying Liu, Yuxiu Li, Zhiyuan Hu, Liming Xie
Correct classification diagnosis of diabetes is critical for timely and appropriate treatment, which partially depends on the multiple islet autoantibodies measurement and combined analysis. This study reports plasmon-enhanced fluorescence protein microchip method, a fast, high-throughput, and high sensitive method, to measure circulating islet autoantibodies. This method can achieve islet autoantibodies combined analysis within a few hours by using a few microliters of serum. Combined islet autoantibodies analysis improved discriminatory ability, especially the diagnostic sensitivity...
August 1, 2018: Journal of Biomedical Nanotechnology
Yonghong Wang, Baofang Wen, Hongli Yu, Dejun Ding, JingJing Zhang, Yunxiang Zhang, Limin Zhao, Weifen Zhang
Nasopharyngeal carcinoma (NPC) is a common epithelial malignancy that occurs in the nasopharynx and it is one of the high incidences of malignant tumors in China. As previous reports, berberine hydrochloride (BH) possesses a repressive effect on the proliferation of various cancer types. But the application of BH was hampered for a long time due to its hydrophobic properties, along with poor stability and bioavailability. In this study, folate acid modified chitosan nanoparticles loaded berberine hydrochloride (BH/FA-CTS NPs) were prepared by the ionic cross-linking technique, the physicochemical properties and the influence of BH/FA-CTS NPs on proliferation, migration and apoptosis in human nasopharyngeal carcinoma CNE-1 cells were studied in vitro and in vivo...
August 1, 2018: Journal of Biomedical Nanotechnology
Xiao Liang, Weili Liao, Huaxiong Cai, Sui Jiang, Siqi Chen
This study examined the compatibility of 3D-printed artificial teeth and extracted teeth by combining oral cone-beam computed tomography (CBCT) and multi-jet printing technology to print the extracted teeth in vitro. The 3D-printed artificial teeth were then used to choose a master gutta-percha with an appropriate working length and taper to fill root canals. The quality of root canal-filling was evaluated via X-ray. Twenty orthodontically extracted premolars with a single root canal were collected and CBCT-scanned, and the scan data were extracted and converted to 3D models using MIMICS software, which in turn were used to 3D-print artificial teeth using multi-jet printing technology...
August 1, 2018: Journal of Biomedical Nanotechnology
Qianqian Song, Renshu Zhang, Lei Lei, Xingyi Li
In the present study, we reported the generation of a molecular hydrogel of succinated paclitaxel (PTX-SA) by a self-hydrolytic strategy for potential local cancer chemotherapy. Upon self-hydrolysis of the ester bond of PTX-SA in phosphate-buffered saline (pH = 7.4) for 24 h, a PTX-SA supramolecular hydrogel formed spontaneously with a minimal gelation concentration of 0.25 wt%. The formed PTX-SA supramolecular hydrogel displayed a filamentous nanostructure, the nanofibers of which were typically several micrometers in length with a diameter of 10-15 nm...
August 1, 2018: Journal of Biomedical Nanotechnology
Yi Deng, Guoqin Chen, Min Ye, Yingyan He, Zehua Li, Xianbao Wang, Caiwen Ou, Zhimou Yang, Minsheng Chen
Generally, nitric oxide (NO) is an important multi-functional cardioprotective soluble gas molecule. However, it may be detrimental when in excessive levels or combined with O2- a kind of reactive oxygen species (ROS)-to form ONOO-. The latter will rapidly decompose to highly reactive oxidant components. ROS will be abundantly produced during the ischemia/reperfusion (I/R) procedure. Therefore, an NO donor coupled with another antioxidant would be a more promising strategy for I/R treatment. In this study, we report on a novel self-assembly supramolecular hydrogel capable of constantly releasing both NO and curcumin (Cur) simultaneously, and we found that the combinational treatment of Cur and NO from the gel could efficiently reduce I/R injuries...
August 1, 2018: Journal of Biomedical Nanotechnology
Xiaoyong Wang, Lan Zhang, Junqing Wang, Xuan Liu, Peng Lv, Jie Zeng, Gang Liu
Triangular Ag nanoplates with a thickness of 5 nm and tunable edge lengths were fabricated using a seed-mediated protocol, featuring enhanced near-infrared absorption as the edge length of nanoplates increased. The photoacoustic (PA) efficiency of these Ag nanoplates were assessed. Nanoplates with an edge length of 100 nm (r1) performed best among others in the in vitro assessment. In the following in vivo test, r1 nanoplates were also found to boost the PA signal of tumor vessels, while a detailed PA imaging of tumor vasculature was obtained...
August 1, 2018: Journal of Biomedical Nanotechnology
Jing Xin, Sijia Wang, Jing Wang, Jiazhuang Wang, Lei Fu, Lijian Shen, Zhenxi Zhang, Cuiping Yao
The poor cell membrane penetration ability of photosensitizers resulted in the limited antitumor effect, thereby hampered their potential in clinical translation. The high toxic side effect and multidrug resistance of chemotherapeutic agents during in clinical chemical therapy should be resolved. Nanosystem integrated with photosensitizer and novel targeting chemotherapy agent may be an effective strategy for overcoming clinical or preclinical drawbacks of monotherapy and enhancing therapeutic effect. Therefore, a nanosized micelle F127 integrated with Apogossypolone (ApoG2) and Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS4) (referred as F127-ApoG2@AlPcS4) was synthesized to induce the cell death quickly for reducing the risk of resistance and enhancing gastric cancer therapeutic efficiency by combining AlPcS4/photodynamic therapy and ApoG2/chemotherapy...
August 1, 2018: Journal of Biomedical Nanotechnology
Mimi Lin, Suyan Shan, Peipei Liu, Liwei Ma, Libin Huang, Mei Yang, Tom Lawson, Zhifeng Wang, Zhenguo Huang, Bingyang Shi, Lu Yan, Yong Liu
An efficient and targeted treatment for tumor cells is demonstrated. This targeting is based upon the strong affinity between hydroxyl-functional groups on graphene and acidic tumors. The hydroxylated graphene (GOH) with a unique 2D architecture further improve the targeting capacity of the system via an enhanced permeability and retention (EPR) process. Polyethylene glycol (PEG) was employed for better biocompatibility and the antitumor drug doxorubicin (DOX) was then incorporated. These additions created a biocompatible system with a superior pH-dependent drug release property...
August 1, 2018: Journal of Biomedical Nanotechnology
Lutao Jiang, Yan Liang, Qingqing Huo, Yuji Pu, Wei Lu, Shangcong Han, Jie Cao, Bin He, Yong Sun
Bio-inspired supramolecular self-assembly have been widely explored in biomedical engineering, especially in the field of drug delivery. Here, viral capsid analogue pH-Sensitive polymeric micelles HA-Hyd-DOX were reported, where natural polysacarrides hyaluronic acid (HA) and anticancer drug doxorubicin (DOX), were linked through a hydrazone bond with a high drug loading content of 33.09 wt%. The polymeric micelles look like artificial virus capsids from "core-shell" structures. In addition, the polymeric backbone HA and hydrazone bonds were destroyed in the presence of hyaluronidase in cancer cells and under the acidic conditions of pH = 5 respectively, thereby prodrug-based polymeric micelles could penetrate into the tumor and DOX could be released in lysosomes to enhance anticancer efficacy...
August 1, 2018: Journal of Biomedical Nanotechnology
Yuanyuan Yang, Qiling Chen, Siyu Li, Wen Ma, Guangyu Yao, Fei Ren, Zheng Cai, Peng Zhao, Guochao Liao, Jingyuan Xiong, Zhiqiang Yu
Despite the great achievements of nanomedicines made in cancer chemotherapy, precise tumor targeting and deep penetration are still major challenges. Many nanomedicines can only passively accumulate near leaky site of tumor vessels through the enhanced permeability and retention (EPR) effect and cannot reach the deep region of tumor. To improve the tumor targeting, penetration and retention efficiency, an iRGD-mediated and enzyme-induced precise targeting gold nanoparticles system (iRGD/AuNPs-A&C) was developed by simply coadministering a tumor-homing penetration peptide iRGD (CRGDKGPDC) with a legumain responsive aggregable gold nanoparticle (AuNPs-A&C)...
August 1, 2018: Journal of Biomedical Nanotechnology
Jing Zhang, Song Wang, Zhiting Deng, Li Li, Guanghong Tan, Xin Liu, Hairong Zheng, Fei Yan
Liposome-microbubble complexes (LMC) have become a promising therapeutic carrier for ultrasound-triggered local drug release. However, it is still desirable for the released drugs to be delivered to tumors as effectively as possible. Here, we fabricated iRGD-targeted paclitaxel-loaded liposome-microbubble complexes (iRGD-PTX-LMC) and investigated the feasibility of enhancing the local drug delivery to breast tumors by using these complexes along with ultrasound irradiation. Our results showed that iRGD-modified PTX-loaded liposomes (iRGD-PTX-PL) were successfully conjugated to the surface of microbubbles (MBs) through biotin-avidin linkage...
August 1, 2018: Journal of Biomedical Nanotechnology
Meijiao Zhang, Shizhu Zang, Guangbo Ge, Lingling Jin, Yi Xin, Huizhen Li, Pingkun Liu, Xudong Hou, Dacheng Hao, Lu Chen, Qi Zhou, Jie Hou
CD22 is an important drug target for the treatment of autoimmune diseases and B cell-derived malignancies. In this study, N-acetylneuraminic acid functionalized quantum dots nanoconjugate was synthesized and used for targeting and fluorescence imaging of CD22 on living cells. The nanoprobe was prepared by conjugating N-acetylneuraminic acid (NANA) on the carboxyl groups modified CdSe/ZnS quantum dots (COOH-QDs) via NHS/EDC mediated esterification. The NANA-QDs nanoprobe showed excellent size distribution, very low cytotoxicity and super fluorescent properties for biological imaging applications...
August 1, 2018: Journal of Biomedical Nanotechnology
Weikang Hu, Mei Ying, Shengmin Zhang, Jianglin Wang
Micro/nanoscale carrier is a crucial component of the drug delivery system that enables to be well designed for improving the pharmacological and therapeutic properties of drug administration. Herein we systemically review a special vector of natural poly(amino acid) (PAA) that has been extensively applied in the controlled delivery of drug, protein and gene due to its excellent biocompatibility, controlled degradability, and flexible physicochemical modification. Natural PAA is a group of poly(ionic) molecules that present various biological roles and putative technical functions...
August 1, 2018: Journal of Biomedical Nanotechnology
Guilong Zhang, Lukui Chen, Wanghao Chen, Bingqian Li, Yongbo Yu, Fan Lin, Xiaoyuan Guo, Hong Wang, Guojian Wu, Bin Gu, Wei Miao, Jun Kong, Xingxing Jin, Guoqing Yi, Yang You, Xinhui Su, Ning Gu
Inflammatory response generated by ischemic stroke commonly affects functional or structural recovery. The aim of this study was to examine the IFN-γ caused inflammatory effects on NSCs in vitro and in vivo. We found that IFN-γ did not affect NSCs proliferation but increased the SOD2 level of inflammatory oxidative stress in NSCs culturing. High dose IFN-γ (500 ng) injection aggravated the level of inflammation in the cerebral ischemic model but did not alter the repairing functions of the NSCs in vivo. NSCs based treatment, including the NSCs-IFN-γ combined treatment, significantly improved the ischemic microenvironment by decreasing CD4+, CD8+ T cells and microglia infiltration...
June 1, 2018: Journal of Biomedical Nanotechnology
Yuchan Ma, Mingyue Lu, Yan Deng, Ruyan Bai, Xi Zhang, Delei Li, Kunlei Zhang, Rong Hu, Yunhui Yang
In this work, a nano-mimetic enzyme Co3O4 nanoparticles with catalytic effect on the reduction of H2O2, was synthesized and used to label C-reactive protein antibody. Au nanoparticles (Au NPs) were loaded on COF-TpPa-1 to form Au NPs@COF-TpPa-1 with good biocompatibility and adsorption ability. A sandwich C-reactive protein immunosensor was prepared using Au NPs @COF-TpPa-1 as the immobilization matrix. The catalytic current of Co3O4 nanoparticles to the reduction of H2O2 was measured by the chronoamperometry which is in proportion to the concentration of CRP...
June 1, 2018: Journal of Biomedical Nanotechnology
Azimeh Rajaee, Xie Wensheng, Lingyun Zhao, Shi Wang, Yaqiang Liu, Zhaoxia Wu, Junjie Wang, Feng Si-Shen
Recently bismuth-based nanoparticles have drawn extensive attention as radiosensitizer in radiotherapy due to high atomic number, low toxicity, and low cost. This study aims to introduce the applicability of bismuth ferrite nanoparticles (BFO, BiFeO3) as a new multifunctional theranostic agent for radiotherapy, magnetic resonance imaging (MRI), and computed tomography (CT) as well as magnetic hyperthermia mediator. After evaluation of BFO nanoparticles biocompatibility which were synthesized by conventional sol-gel method, we investigated dose enhancement property of BFO nanoparticles with gel dosimetry, clonogenic, and cck8 assay...
June 1, 2018: Journal of Biomedical Nanotechnology
Neha Atulkumar Singh, Abul Kalam Azad Mandal, Zaved Ahmed Khan
RATIONAL: Accumulation of amyloid beta fibrils is the pathological hallmark of Alzheimer's disease. Epigallocatechin-3-gallate (EGCG) has shown to possess potent anti-amyloidogenic, metal chelation and antioxidant properties. However, its therapeutic potential is limited in-vivo due to its poor bioavailability and stability. Therefore, the present study aims to evaluate the neuroprotective role of EGCG nanoparticles (nanoEGCG) against Al(III)-induced Aβ42 fibrillation in-vitro. METHOD: NanoEGCG was synthesized and its physiochemical characterization was performed...
June 1, 2018: Journal of Biomedical Nanotechnology
Xibo Li, Ningning Li, Kastytis Sidlauskas, Houli Li, Chao Zhang, Mingli Peng, Qinlu Zhang, Kai Hua, Lili Guo, Fuqiang Li, Ying Zhang, Mingwei Chen, Guanjun Zhang, Yihang Pan, Linlin Gao, Yali Cui
Doxorubicin (Dox) is one of the most widely used chemotherapeutic agents for many types of cancer, including hepatocellular carcinoma. However, clinical applications of Dox are limited due to its non-selective cytotoxicity that results in severe adverse effects. To tackle this problem targeted delivery of Dox exclusively to tumour milieu has become clinically prioritised. In this study, we first synthesized and validated Dextran coated GoldMag Nanoparticles (DGMNs) as a potential delivery vehicle for Dox. We then evaluated the cytotoxicity of Dox-DGMNs, the drug and carrier composites, under guidance of external magnetic field (EMF) in hepatocellular carcinoma cell lines and in tumour grafts...
June 1, 2018: Journal of Biomedical Nanotechnology
Chunhua Ren, Yang Gao, Jinjian Liu, Yumin Zhang, Guojuan Pu, Lijun Yang, Fan Huang, Cuihong Yang, Zhimou Yang, Jianfeng Liu
Supramolecular nanofibers based on D-amino acid-containing peptide self-assembly have attracted increased interest recently because of their superior biostability. However, the construction of nanostructures containing D-amino acids is still insufficient at present, and their application in biomedical fields should be further explored. Herein, we demonstrated that the aggregation property of hydrophobic anticancer tyroservaltide (YSV) could be decreased by introducing D-amino acids. Using such strategy, we fabricated a novel anticancer hydrogelator based on the D/L-peptide of NapGDFDFDYGYSV (D-YSV)...
June 1, 2018: Journal of Biomedical Nanotechnology
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