journal
https://read.qxmd.com/read/38186025/somatic-deficient-mismatch-repair-assessed-by-immunohistochemistry-and-clinical-features-in-brazilian-glioblastoma-patients
#21
JOURNAL ARTICLE
C A F Yamada, S M F Malheiros, L L F Do Amaral, C L P Lancellotti
BACKGROUND: Glioblastoma (GBM) is the most frequent primary malignant CNS tumor. Deficient mismatch repair (dMMR) is associated with better prognosis and is a biomarker for immunotherapy. Evaluation of MMR by immunohistochemistry (IHC) is accessible, cost effective, sensitive, and specific. AIM: Our objective was to investigate MMR proteins in adult GBM patients. MATERIALS AND METHODS: We retrospectively analyzed 68 GBM samples to evaluate the proficiency of MMR genes expression assessed by IHC...
December 28, 2023: Experimental Oncology
https://read.qxmd.com/read/38186024/significance-of-osteopontin-for-predicting-aggressiveness-of-prostate-cancer
#22
JOURNAL ARTICLE
N Lukianova, Т Zadvornyi, Т Borikun, О Mushii, А Pavlova, А Tymoshenko, Е Stakhovskyi, I Vitruk, V Сhekhun
BACKGROUND: Effective prediction of the course of prostate cancer (PCa) and the stratification of treatment tactics largely depend on the use of prognostic markers that reflect the molecular and biological features of tumors. In view of the important role of matricellular proteins in the modulation of the growing tumor and metastasis of the hormone-dependent neoplasms, the aim of the work was to study the expression of osteopontin (OPN) at the protein and mRNA levels in the PCa tissue in order to assess the significance of this protein for predicting the aggressiveness of PCa...
December 28, 2023: Experimental Oncology
https://read.qxmd.com/read/38186023/immunophenotype-of-leukemic-cells-in-chronic-lymphocytic-leukemia-patients-with-notch1-and-sf3b1-gene-mutations
#23
JOURNAL ARTICLE
N Golyarnik, І Абраменко, G Movchan, Z Martina, I Dyagil, A Chumak, D Bazyka
BACKGROUND: The typical chronic lymphocytic leukemia (CLL) immunophenotype is vital for diagnosis, but the expression of some antigens varies and has prognostic value. There are data that reduced CD20 expression is associated with NOTCH1 and SF3B1 gene mutations. AIM: To determine a high-risk group of CLL patients for prediction of unfavorable NOTCH1 and SF3B1 gene mutations based on immunophenotyping of leukemic cells. MATERIALS AND METHODS: Flow cytometric and molecular-genetic analysis (mutations of NOTCH1, SF3B1, and TP53 genes using the polymerase chain reaction followed by direct sequencing) was performed in a group of 86 previously untreated CLL patients...
December 28, 2023: Experimental Oncology
https://read.qxmd.com/read/38186022/effect-of-b-subtilis-%C3%B0-%C3%B0-v-b-7724-lectin-on-the-activity-of-effectors-of-cellular-antitumor-immunity-of-mice-with-lewis-lung-carcinoma
#24
JOURNAL ARTICLE
A Chumak, N Fedosova, N Cheremshenko, O Karaman, Т Симчич, I Voyeykova
AIM: To evaluate the effect of B. subtilis IMV B-7724 lectin on the functional activity of macrophages (Mph), natural killer (NK) cells and cytotoxic lymphocytes (CTL) of mice bearing Lewis lung carcinoma (LLC). MATERIALS AND METHODS: The studies were performed on C57Bl/6J mice; LLC was used as an experimental transplantable tumor. The lectin from B. subtilis IMV B-7724 was administered to LLC-bearing mice subcutaneously at a dose of 1 mg/kg of body weight for 10 days...
December 28, 2023: Experimental Oncology
https://read.qxmd.com/read/38186021/prognostic-implications-of-pd-l1-expression-and-loss-of-pten-in-patients-with-rhabdomyosarcoma-ewing-s-sarcoma-and-osteosarcoma
#25
JOURNAL ARTICLE
H M Abd Elmoneim, H F Huwait, H Nafady-Hego, Fez A Mohamed
BACKGROUND: In children, osteosarcoma (OS), Ewing's sarcoma (ES), and rhabdomyosarcoma (RMS) are the most common sarcomas. A link between the anti-programmed death ligand-1 PD-L1 and the tumor suppressor phosphatase and tensin homologue (PTEN) expression has been described in many tumors. The aim of this work is to determine clinicopathological relationships and the possible prognostic significance of PD-L1 and PTEN expression in rhabdomyosarcoma (RMS), Ewing's sarcoma (ES), and osteosarcoma (OS)...
December 28, 2023: Experimental Oncology
https://read.qxmd.com/read/38186020/features-of-col1a1-expression-in-breast-cancer-tissue-of-young-patients
#26
JOURNAL ARTICLE
V Chekhun, O Mushii, T Zadvornyi, T Borikun, О Martyniuk, E Kashuba, A Kryzhanivska, A Andriiv, I Diakiv, N Lukianova
BACKGROUND: In the last decades, the incidence of breast cancer (BCa) in young women has been increasing steadily. The quantitative indicators of expression of collagen, which play important role in stromal microenvironment, and their association with the age and survival rates of BCa patients have not been yet definitively clarified. AIM: To investigate the relationship between the COL1A1 gene expression at the mRNA and protein levels in BCa tissue and the clinicopatological features and survival rates of BCa patients of different age groups...
December 28, 2023: Experimental Oncology
https://read.qxmd.com/read/38186019/plastic-surgery-of-wound-defects-with-free-grafts-after-malignant-skin-tumors-excision-a-pilot-study
#27
JOURNAL ARTICLE
S I Korovin, S A Dedkov, V V Ostafiichuk, M M Kukushkina
AIM: To evaluate the effectiveness of applying negative pressure bandages (VAC bandage) in patients with malignant skin tumors after closing defects with free skin grafts and to compare it with fixation of skin grafts by the ordinary ointment bandages. MATERIALS AND METHODS: 61 patients with malignant skin tumors who underwent surgical treatment at the National Cancer Institute from 2019 to 2023 were included in the study. For the wound defects closure, the split skin grafts were applied in all patients...
December 28, 2023: Experimental Oncology
https://read.qxmd.com/read/38186018/a-rare-uterine-tumor-disseminated-peritoneal-leiomyomatosis-clinical-observations
#28
JOURNAL ARTICLE
V Svintsitskyi, M Krotevych, M Iegorov, S Trokhymych, S Sendetskyi
BACKGROUND: Disseminated peritoneal leiomyomatosis (DPL) is an extremely rare benign disease characterized by widespread lesions of the abdominal cavity, pelvis, and retroperitoneal space with tumor nodules of varying size and number, which are benign neoplasms consisting of smooth muscle fibers in their histological structure. AIM: To analyze clinical cases of DPL with a concise review of the current state of the DPL diagnosis and treatment. MATERIALS AND METHODS: We analyzed 5 clinical cases of DPL of female patients aged 39-50 years (mean age 46...
December 28, 2023: Experimental Oncology
https://read.qxmd.com/read/38186017/the-cryogenic-technologies-application-in-the-complex-treatment-of-gallbladder-adenocarcinoma-with-invasion-into-the-portal-vein-branches-case-report
#29
JOURNAL ARTICLE
O Dronov, Y Kozachuk, Y Bakunets, P Bakunets, F Prytkov
The right trisectionectomy is the main treatment modality for locally advanced gallbladder cancer with invasion of the intraparenchymal portal vein branches because it allows the achievement of negative resection margins (R0). However, only 10%-25% of such patients are eligible for surgery. The cryosurgical method has been successfully used in the complex treatment of hepatopancreatobiliary malignant neoplasms for many years. The possibility of its application close to major blood vessels is one of its advantages...
December 28, 2023: Experimental Oncology
https://read.qxmd.com/read/38186016/repeated-breast-conserving-surgeries-as-reflection-of-the-evolution-in-breast-cancer-treatment-case-report-with-literature-review
#30
REVIEW
I Galaychuk
The clinical case of a patient with multicentric breast cancer who underwent organ-sparing surgery after neoadjuvant chemo-radiation therapy is presented. An ipsilateral cancer recurrence was diagnosed 8 years after the first operation. The repeated organ-sparing surgery (lumpectomy) was done with a good cosmetic result and without disease progression during 1-year follow-up. The literature review shows that neoadjuvant systemic therapy accounting for molecular subtypes of cancer has radically changed breast cancer surgeries...
December 28, 2023: Experimental Oncology
https://read.qxmd.com/read/38186015/epigenetic-alterations-driving-oncogenesis-in-head-and-neck-squamous-cell-carcinoma
#31
JOURNAL ARTICLE
D Yasothkumar, K Ramalingam, P Ramani
To the Editor, Head and neck squamous cell carcinoma (HN- SCC) accounts for about 600,000 new cases globally every year and stands the sixth most common cancer, arising from the squamous epithelium. It is localized in the head and neck area involving oral cavity, pharynx, and larynx. Despite the rigorous therapy, the 5-year overall survival remains poor in HNSCC and has not changed appreciably in the last 30 years. The majority of patients develop resistance to chemotherapeutic agents, and cancer progression occurs...
December 28, 2023: Experimental Oncology
https://read.qxmd.com/read/37824778/features-of-breast-cancer-in-patients-of-young-age-search-for-diagnosis-optimization-and-personalized-treatment
#32
JOURNAL ARTICLE
V Chekhun, О Martynyuk, Ye Lukianova, O Mushii, T Zadvornyi, N Lukianova
The statistical data of the recent decades demonstrate a rapid growth of breast cancer (BCa) incidence and a tendency toward its increase especially in young women. In the structure of morbidity of women in the age group of 18-29 years, BCa ranks first and in the age range of 15-39 years, BCa is one of the leading causes of mortality. According to the data of the epidemiological and clinical studies, the young age is an independent unfavorable prognostic factor of BCa that is associated with an unfavorable prognosis and low survival rates and is considered an important predictor of the disease aggressiveness, a high risk of metastasis and recurrence...
October 11, 2023: Experimental Oncology
https://read.qxmd.com/read/37824777/-not-available
#33
JOURNAL ARTICLE
E A Domina, O L Kopylenko, V F Chekhun
Широке впровадження ядерних технологій у промисловість, медицину, науку тощо збільшує кількість фахівців, що піддаються додатковому радіаційному опроміненню...
October 11, 2023: Experimental Oncology
https://read.qxmd.com/read/37824776/clinical-significance-of-brca1-gene-sequencing-and-its-promoter-methylation-testing-in-the-search-strategy-for-therapeutic-targets-in-breast-cancer-treatment
#34
JOURNAL ARTICLE
L Fishchuk, O Lobanova, Z Rossokha, V Cheshuk, R Vereshchako, Yu Vagyn, V Kashuba, V Vershyhora, O Popova, N Levkovich, O Zemlianska, O Ievseienkova, S Podolska, N Gorovenko
BACKGROUND: Currently, there is a great interest in the genetic testing of BRCA1 and BRCA2 due to the fact that for patients with breast cancer (BC) with pathogenic variants of these genes, the use of the PARP inhibitors could be also provided in addition to implemented treatment protocols. The aim of this study was to characterize the molecular genetic structure of the BRCA1 gene in BC patients without progenitor germline mutations taking into account the methylation state of the promoter region...
October 11, 2023: Experimental Oncology
https://read.qxmd.com/read/37824775/pathological-significance-of-cdh1-e-cadherin-germline-sequence-variants-in-breast-cancer-patients
#35
JOURNAL ARTICLE
S Tabassum, F Munir, A A Al Awadh, Z Anwar
BACKGROUND: Germline alterations of the CDH1 (E-cadherin) tumor suppressor gene have been reported in several epithelial malignancies like hereditary diffuse gastric cancer and lobular breast cancer. E-cadherin plays a central role in proliferation, maintenance of cell-to-cell adhesion, polarity, and epithelial-mesenchymal transition of tissue cells. It is necessary to analyze the impact of the CDH1 germline sequence variants on protein and predict its clinical significance in breast cancer (BC) progression...
October 11, 2023: Experimental Oncology
https://read.qxmd.com/read/37824774/association-of-mirna-expression-pattern-with-outcome-of-letrozole-therapy-in-breast-cancer-patients
#36
JOURNAL ARTICLE
O Pridko, T Borikun, O Rossylna, A V Rusyn
UNLABELLED: Breast cancer (BC) remains the most prevalent tumor and the leading cause of death among women worldwide, despite the advancements in diagnosis and new treatments. A significant challenge in BC treatment is the acquired or de novo resistance of tumors to systemic therapy. To overcome this obstacle, personalized treatment is needed, with a focus on finding biomarkers capable of predicting the response to therapy. MicroRNAs (miRNAs) have emerged as potential markers due to their diverse clinical applications...
October 11, 2023: Experimental Oncology
https://read.qxmd.com/read/37824773/the-study-of-prognostic-value-of-micrornas-mir-10b-and-155-and-cdkn2a-p16ink4a-in-oral-squamous-cell-carcinoma
#37
JOURNAL ARTICLE
О Kravets, O Burtyn, T Borikun, O Rossylna
BACKGROUND: Oral squamous cell carcinoma (OSCC) is one of the most common types of cancer worldwide. Disco- vering novel prognostic markers for OSCC can improve treatment outcomes by allowing for more effective therapy strategies. AIM: To identify the prognostic value of CDKN2A (p16INK4a) and miRNAs involved in its regulation as markers of OSCC. MATERIALS AND METHODS: The work is based on the results of the examination and treatment of 70 patients with stage II-IV OSCC...
October 11, 2023: Experimental Oncology
https://read.qxmd.com/read/37824772/aberrant-methylation-of-cancer-related-genes-in-vietnamese-breast-cancer-patients-associations-with-clinicopathological-features
#38
JOURNAL ARTICLE
Linh Dieu Vuong, Quang Ngoc Nguyen
BACKGROUND: Epigenetic alteration is one of the most common molecular changes identified in the progression of breast cancer (BC). AIM: To study the frequency and relation between methylation of BRCA1, MLH1, MGMT, GSTP1, APC, RASSF1A, p16, WIF, and EGFR and the clinicopathological features in Vietnamese BC patients. MATERIALS AND METHODS: Methylation-specific polymerase chain reaction (MS-PCR) and SPSS 20.0 software were utilized in order to identify methylated frequency as well as evaluate its relationship with the patient's clinical features...
October 11, 2023: Experimental Oncology
https://read.qxmd.com/read/37824771/epidermal-growth-factor-receptor-egfr-polymorphic-variations-216g-t-191-c-a-pose-a-high-risk-to-patients-with-malignant-glioma
#39
JOURNAL ARTICLE
Wani Zahoor, Arshad A Pandith, Syed Nisar, Iqbal Qasim, Menka Surana, Farooq A Ganie, Usma Manzoor, Sajad H Arif, Shayaq Ul Abeer Rasool, Adil Lateef, Parveen Shah, Rashid A Bhat
BACKGROUND: Malignant gliomas are the most frequent and lethal brain tumors. Their molecular aspects remain intangible but current studies have pointed to certain genetic polymorphic loci that pose the risk. The polymorphic sequence variations of the epidermal growth factor receptor gene (EGFR) pathway play a vital role in the glioma risk, and the EGFR variants (216G>T and 191C>A) are identified to affect the risk for the development of different tumors including glioma. AIM: To examine genetic variations of EGFR T rs712829 (216G/T) and rs712830 (191C>A) with respect to glioma risk...
October 11, 2023: Experimental Oncology
https://read.qxmd.com/read/37824770/effect-of-anti-tslpr-monoclonal-antibody-on-viability-proapoptotic-genes-expression-and-production-of-pro-inflammatory-cytokines-in-mcf-7-and-a549-cells
#40
JOURNAL ARTICLE
Alyaa Rakha, Roba M Talaat, Eman A El-Maadawy, Adel A Gurguis
BACKGROUND: Thymic stromal lymphopoietin (TSLP) and its receptor (TSLPR) are expressed in various cancer cells. However, their role in cancer development is not well defined. AIM: To investigate the effects of anti-TSLPR antibody on the viability, proapoptotic genes expression, and production of pro-inflammatory cytokines in MCF-7 and A549 cancer cells. MATERIALS AND METHODS: MCF-7 and A549 cells were exposed to anti-TSLPR monoclonal antibody for 24, 48, and 72 h...
October 11, 2023: Experimental Oncology
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