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Experimental Oncology

S Vernygorodskyi, T Rekun, P Zhuchenko
AIM: To study and compare the expression patterns of mucins in the fetal gastroesophageal junction (GEJ) region and adenocarcinomas of the GEJ in adults using histochemical method. MATERIAL AND METHODS: To reveal the expression of different mucins, tissue sections from formalin-fixed paraffin-embedded tissue blocks of fetal GEJ and carcinomas of GEJ were stained by the following histological stains: hematoxylin and eosin, periodic acid-Schiff (PAS), alcian blue (AB), pH 2...
October 2018: Experimental Oncology
A Akbarzadeh, R Khalilov, E Mostafavi, N Annabi, E Abasi, T Kafshdooz, R Herizchi, T Kavetskyy, S Saghfi, A Nasibova, S Davaran
Dendrimers dendritic structural design holds vast promises, predominantly for drug delivery, owing to their unique properties. Dendritic architecture is widespread topology found in nature and offers development of specific properties of chemical substances. Dendrimers are an ideal delivery vehicle candidate for open study of the effects of polymer size, charge, and composition on biologically relevant properties such as lipid bilayer interactions, cytotoxicity, bio-distribution, internalization, blood plasma retention time, and filtration...
October 2018: Experimental Oncology
T S Gerashchenko, E V Denisov, N M Novikov, L A Tashireva, E V Kaigorodova, O E Savelieva, M V Zavyalova, N V Cherdyntseva, V M Perelmuter
AIM: To identify gene expression profiles involved in drug resistance of different morphological structures (tubular, alveolar, solid, trabecular, and discrete) presented in breast cancer. MATERIAL AND METHODS: Ten patients with luminal breast cancer have been included. A laser microdissection-assisted microarrays and qRT-PCR were used to perform whole-transcriptome profiling of different morphological structures, to select differentially expressed drug response genes, and to validate their expression...
October 2018: Experimental Oncology
T V Zadvornyi, N Yu Lukianova, T V Borikun, V F Chekhun
AIM: To investigate the biological effects of exogenous lactoferrin (LF) on phenotypic profile and invasiveness of human prostate cancer (PC) cells in vitro. MATERIALS AND METHODS: Human PC cell lines (LNCaP, DU-145) were cultured with an exogenous LF at a dose corresponding to IC30. The expression levels of steroid hormone receptors (androgen receptor, estrogen receptor, progesterone receptor), Her2/neu, Ki-67, E- and N-cadherin, were monitored by immunohistochemical analysis...
October 2018: Experimental Oncology
T T Agishev, E E Topuzov, D A Krasnozhon, A O Petrachkov, R V Pavlov, S H Doniyarov
AIM: Late radiation injury in the form of radiation-induced fibrosis (RIF) is one of the many complications of radiation therapy. The aim was to evaluate oxygen perfusion in the skin in the area of late radiation injury manifested as RIF in patients with breast cancer. MATERIALS AND METHODS: Based on our first-hand experience in treating late radiation injures of soft tissues in patients with breast cancer, we measured oxygen perfusion of the skin (tсрО2) in the area of late radiation injury using a transcutaneous monitor (oximeter) TCM 400 (Radiometer, Denmark)...
October 2018: Experimental Oncology
Yu V Dumansky, O V Syniachenko, P A Stepko, Ye D Yehudina, O Yu Stoliarova
AIM: To study the nature of different variants of paraneoplastic syndrome (PNPS) in lung cancer, taking into account the features of the tumorous process and the complications of radiochemotherapy. PATIENTS AND METHODS: We performed an analysis of the data of 1,669 patients with lung cancer aged between 24 and 87 years, among whom there were 89% of men and 11% of women. The ratio of small cell and non-small-cell histological variants of the lung cancer was 1: 4, IB, IIA, IIB, IIIA, IIIB and IV stages of cancer - 1:2:6:58:43:57...
October 2018: Experimental Oncology
S M Grybach, L Z Polishchuk, V F Chekhun
AIM: To analyze the survival of patients with breast cancer (BC) depending on age, molecular subtype of the tumor and the presence of metabolic syndrome. PATIENTS AND METHODS: We have analyzed the results of examination and treatment of 202 patients with BC of stages I-III. The patients were distributed by age into 2 groups. The group 1 included 86 elderly patients (from 65 to 84 years old), the group 2 - 116 younger patients (from 32 to 64 years). An overall 1-, 3- and 5-year survival rates of the treated patients were assessed...
October 2018: Experimental Oncology
P Harper, O Hald, B A Lwaleed, A Kyyaly, D Johnston, A J Cooper, B Birch
AIM: The aim of this study was to determine the effect of morphine on bladder cancer cell proliferation and apoptosis in vitro. MATERIALS AND METHODS: MTT assay was used to measure percentage growth of RT-112 human bladder cancer cells after 72 hours of morphine/morphine + naloxone treatment. Expression of µ-opioid receptors was assessed by Western blot and finally, apoptotic assay with CellEvent Caspase-3/7 Green Detection Reagent was carried out using confocal microscopy...
October 2018: Experimental Oncology
N A Chrysanthakopoulos, N S Dareioti
AIM: The present study aimed to investigate any possible association between ABO blood groups and lung cancer. MATERIALS AND METHODS: The study was conducted on 122 lung cancer patients and 1,255 matched-healthy individuals that were reviewed retrospectively. Chi-square and logistic regression models were used for statistical analysis. RESULTS: No significant difference between lung cancer patients and the control group was recorded regarding ABO blood types and the risk of lung cancer (p = 0...
October 2018: Experimental Oncology
О L Apykhtina, S M Dybkova, L M Sokurenko, Yu B Chaikovsky
Cadmium compounds are highly toxic substances characterized by mutagenic, genotoxic and carcinogenic effects, and having high cumulative properties. Application of cadmium nanoparticles (NPs) in medicine stimulates the study of their mechanism of action at the cellular level and at the level of organs and systems, determination of biomarkers of their action, particularly in comparison with the ionic form. The aim of the study was to compare the features of cytotoxic and genotoxic effects of cadmium sulfide (CdS) NPs of different sizes on cell cultures of different histogenesis with those of cadmium chloride (CdCl2)...
October 2018: Experimental Oncology
R Tkachenko, A Golovko, O Kuryk
Adrenocortical cancer is an extremely rare tumor presenting with extensive locoregional spread at the time of diagnosis. Due to the diagnostic difficulties preoperatively and a lack of effective treatment options, patients have poor prognosis. Patients succumb to metastases within a couple of months. Only 20 cases have been so far reported in the literature with a medium disease-free survival up to 2 years. We present a case of a locoregional recurrence of adrenocortical cancer 18 years after left adrenalectomy...
October 2018: Experimental Oncology
(no author information available yet)
Ukrainian oncology suffered a grievous loss. Professor Svitlana Pavlivna Sidorenko, a prominent scientist, head of the Department of Molecular and Cellular Pathobiology of the R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences of Ukraine, a Corresponding member of the National Academy of Sciences of Ukraine, after a long illness, died on August 26, 2018 at the age of 64.
October 2018: Experimental Oncology
(no author information available yet)
Our colleague Professor Yurii Yosypovych Kudryavets, talented scientist-oncologist, Head of the Department of Experimental Cell Systems of the R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (IEPOR), the NAS of Ukraine, passed away at the age of 71.
October 2018: Experimental Oncology
I V Abramenko, N I Bilous, A A Chumak, I S Dyagil, Z V Martina
Deregulation of NOTCH1-signalling pathway is common in chronic lymphocytic leukemia (CLL). The most of studies are focused on detection of the hotspot c.7541_7542delCT NOTCH1 mutations in exon 34, while studies of mutations in the 3'UTR region are rare. The aims of work were to evaluate the frequencies of mutations in the 3'UTR region of the NOTCH1 gene (9:136,495553-136,495994) in Ukrainian CLL patients, the distribution of rs3124591 genotypes located in that area, and association of NOTCH1 mutations with structure of B-cell receptor...
October 2018: Experimental Oncology
I P Nesina, N P Iurchenko, L G Buchynska
AIM: To study the expression of adhesion markers (E-cadherin, β-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). MATERIALS AND METHODS: Expression of E-cadherin, β-catenin and vimentin was studied immunohistochemically in the samples of surgical material of 55 EC patients stage I-III. The proliferation index was determined by flow cytometry. RESULTS: In the group of vimentin-negative EC, tumors of low differentiation grade and deep invasion in myometrium as well as high expression of E-cadherin and β-catenin prevailed compared with the cases with high expression of vimentin...
October 2018: Experimental Oncology
I V Prokhorova, O N Pyaskovskaya, D L Kolesnik, G I Solyanik
BACKGROUND: The efficacy of antimetabolic therapy of malignant neoplasms could not be explained solely by the direct mechanisms of action of such energy metabolism inhibitors as sodium dichloroacetate (DCA) and metformin (MTF). The indirect effects of DCA and MTF on the organs and tissues, which could play significant role in the antitumor activity of these agents, have not been thoroughly explored. AIM: To investigate the effect of MTF, DCA and their combination on the survival of rats with C6 glioma and major haematological and biochemical blood parameters...
October 2018: Experimental Oncology
V F Chekhun, D M Storchai, I N Todor, T V Borikun, N Yu Lukianova
AIM: To investigate the influence of exogenous lactoferrin (LF) on tumor growth, energy and lipid metabolism of Walker-256 carcinosarcoma and to assess genotoxic effects of LF. MATERIALS AND METHODS: The study was performed on Walker-256 tumor-bearing rats. Total lipids and phospholipids were determined by thin-layer chromatography. Comet assay was used to investigate the genotoxic effects of LF. RESULTS: Daily i.p. administrations of exogenous LF at concentrations of 1 mg/kg and 10 mg/kg starting from the 4th day after tumor transplantation suppressed growth of Walker-256 carcinosarcoma by almost 44%...
October 2018: Experimental Oncology
M W Roomi, B Bhanap, A Niedzwiecki, M Rath
Hemangiomas are the most common congenital vascular and benign tumor in infants and children. Most hemangiomas do not cause major symptoms to require intervention, however, the larger hemangiomas have tendency to bleed and may require surgical removal. Experimental studies have demonstrated the role of urokinase plasminogen activator (u-PA), especially cell surface u-PA, as an initiator of extra-cellular matrix proteolysis and associated tumor cell invasion. AIM: To examine, whether the antitumor effects of a specific nutrient mixture are due to induction of apoptosis by inhibition of u-PA...
June 2018: Experimental Oncology
M Sanaei, F Kavoosi, O Mansoori
AIM: Acetylation levels of histones are the result of the balance between histone acetyltransfrases and histone deacetylases activities, which plays an important role in chromatin remodeling and regulation of gene expression. Histone deacetylases inhibitors such as valproic acid, vorinostat have attracted interest because of their ability to induce differentiation and apoptosis of cancer cells. The current study was designed to assess the effect of valproic acid in comparison to and in combination with vorinostat on cell growth inhibition and apoptosis induction in the human colon cancer SW48 cells...
June 2018: Experimental Oncology
G V Gerashchenko, L V Mevs, L I Chashchina, M V Pikul, O P Gryzodub, E O Stakhovsky, V I Kashuba
AIM: To analyze an expression pattern of the steroid and peptide hormone receptors, metabolic enzymes and EMT-related genes in prostate tumors in relation to the presence of the TMPRSS2/ERG fusion; and to examine a putative correlation between gene expression and clinical characteristics, to define the molecular subtypes of prostate cancer. MATERIALS AND METHODS: The relative gene expression (RE) of 33 transcripts (27 genes) and the presence/absence of the TMPRSS2/ERG fusion were analyzed by a quantitative PCR...
June 2018: Experimental Oncology
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