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Experimental Oncology

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https://www.readbyqxmd.com/read/28361866/international-scientific-conference-normal-and-cancer-stem-cells-discovery-diagnosis-and-therapy-october-5-6-2017-kyiv-ukraine
#1
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361865/workshop-with-international-participation-new-trends-in-cancer-research-and-innovative-tumor-vaccines-may-11-12-2017-kyiv-ukraine
#2
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361864/materials-of-international-vactrain-3-rd-swedish-ukrainian-conference-on-cancer-diseases-january-16-17-2017-stockholm-sweden
#3
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361863/trichilemmal-cystis-in-metastatic-melanoma-a-case-report
#4
I Savarese, M Grazzini, A Gori, A D'Errico, L Doni, F Scarfì, P Covarelli, F Di Costanzo, V De Giorgi
The malignant melanoma is a neoplasm associated with a wide variety of cutaneous paraneoplastic syndromes, as dermatomyositis, systemic sclerosis, paraneoplastic pemphigus. We describe a case of four multiple trichilemmal cystis arising on frontal region in the same patient with brain metastasis and unknown primary melanoma and discuss their relationship.
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361862/circulating-tumor-cells-in-breast-cancer-functional-heterogeneity-pathogenetic-and-clinical-aspects
#5
N V Cherdyntseva, N V Litviakov, E V Denisov, P A Gervas, E S Cherdyntsev
Each patient has a unique history of cancer ecosystem development, resulting in intratumor heterogeneity. In order to effectively kill the tumor cells by chemotherapy, dynamic monitoring of driver molecular alterations is necessary to detect the markers for acquired drug resistance and find the new therapeutic targets. To perform the therapeutic monitoring, frequent tumor biopsy is needed, but it is not always possible due to small tumor size or its regression during the therapy or tumor inaccessibility in advanced cancer patients...
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361861/diagnostic-challenges-with-intraoral-myeloid-sarcoma-report-of-two-cases-review-of-world-literature
#6
P Kumar, H Singh, N Khurana, A B Urs, J Augustine, R Tomar
BACKGROUND: Myeloid sarcomas (MS) are rare extramedullary tumors composed of blasts of myeloid lineage that either precede, follow or present concomitantly with acute myeloid leukaemia (AML) or myeloproliferative neoplasms. The diagnosis of MS is especially challenging in patients without an antecedent history of leukemia. METHODS: We present 2 cases of intraoral MS that presented as de novo lesions. A detailed review of cases of intraoral MS that either preceded or presented along with leukemia has been done with emphasis on diagnostic criteria used...
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361860/do-mrps18-2-and-rb-proteins-cooperate-to-control-cell-stemness-and-differentiation-preventing-cancer-development
#7
E Kashuba, M Mushtaq
In childhood tumors, including retinoblastoma, osteosarcoma, and neuroblastoma, the RB-E2F1 pathway is inactivated, as a rule. These tumors arise from precursor cells that fail to undergo the terminal differentiation. Noteworthy, the RB1-encoded protein (RB) does not control the cell cycle in embryonic stem cells. It has not been yet well understood how RB controls cell stemness and differentiation. The question arises why "inactive" RB is required for the survival and stemness of cells? Recently, we have found that overexpression of the RB-binding protein MRPS18-2 (S18-2) in primary fibroblasts leads to their immortalization, which is accompanied by the induction of embryonic stem cell markers and, eventually, malignant transformation...
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361859/the-impact-of-locoregional-treatment-on-survival-of-patients-with-primary-metastatic-breast-cancer
#8
R Liubota, V Cheshuk, R Vereshchako, O Zotov, V Zaichuk, N Anikusko, I Liubota
The aim of the study was to investigate the impact of primary tumor locoregional treatment (surgery or/and radiotherapy) on overall survival in patients with primary metastatic breast cancer (PMBC). MATERIALS AND METHODS: This retrospective study included 295 wo-men aged from 23 to 76 years with PMBC. Among the 295 patients, the effect of locoregional treatment of primary tumor on survival outcomes was evaluated in 177 women with distant metastases at diagnosis of breast cancer. 35 patient received breast surgery (group 1), 95 patients with PMBC - radiotherapy (group 2) and 47 patients - combination of breast surgery and radiation (group 3)...
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361858/impact-of-single-nucleotide-polymorphism-in-chemical-metabolizing-genes-and-exposure-to-wood-smoke-on-risk-of-cervical-cancer-in-north-indian-women
#9
K Satinder, R C Sobti, K Pushpinder
AIM: In the present study, we investigated the hypothesis whether exposure to wood smoke increases the risk of cervical cancer (CC) in North-Indian women who inherit different polymorphic forms of chemical metabolizing genes (GSTM1, GSTT1, GSTP1 and CYP1A1). MATERIALS AND METHODS: One hundred fifty histologically confirmed CC patients and equal number of cancer-free age and ethnicity matched controls were genotyped for genetic polymorphism in chemical metabolizing genes by using polymerase chain reaction/restriction fragment length polymorphism method...
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361857/artemisinin-modulating-effect-on-human-breast-cancer-cell-lines-with-different-sensitivity-to-cytostatics
#10
V F Chekhun, N Yu Lukianova, T V Borikun, T V Zadvorny, A Mokhir
AIM: To explore effects of Artemisinin on a series of breast cancer cells with different sensitivity to typical cytotoxic drugs (doxorubicin - Dox; cisplatin - DDP) and to investigate possible artemisinin-induced modification of the mechanisms of drug resistance. MATERIALS AND METHODS: The study was performed on wild-type breast cancer MCF-7 cell line (MCF-7/S) and its two sublines MCF-7/Dox and MCF-7/DDP resistant to Dox and DDP, respectively. The cells were treated with artemisinin and iron-containing magnetic fluid...
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361856/aberrant-promoter-hypermethylation-of-selected-apoptotic-genes-in-childhood-acute-lymphoblastic-leukemia-among-north-indian-population
#11
M Nikbakht, A K Jha, K Malekzadeh, M Askari, S Mohammadi, R K Marwaha, D Kaul, J Kaur
Promoter hypermethylation mediates gene silencing in many neoplasms. Acute leukemia has been reported to harbor multiple genes aberrantly silenced by hypermethylation. AIM: In present study, we investigated the prevalence of hypermethylation of caspase-8 (CASP8), TMS1 and DAPK genes in correlation with clinicopathological factors in childhood acute lymphoblastic leukemia (ALL). MATERIALS AND METHODS: A case-control study has been conducted based on bone marrow and peripheral blood samples from 125 ALL patients and 100 sex-age matched healthy controls...
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361855/parthenolide-reduces-gene-transcription-of-prosurvival-mediators-in-u937-cells
#12
S Mohammadi, M Zahedpanah, M Nikbakht, M Shaiegan, Ghaffari Hamidollah, M Nikugoftar, B Rahmani, D Hamedi Asl
In acute myeloid leukemia (AML) the functional abnormalities of osteopontin (OPN), NF-kB, PI3K/AKT/mTOR/PTEN pathway or β-catenin have been considered. AIM: To analyze the response of U937 cells to parthenolide (PTL) through the involvement of expression of OPN protein, RelB, AKT1, mTOR, PTEN and β-catenin genes. MATERIALS AND METHODS: The U937 cells were treated with PTL at concentrations of 4 μM (IC25) or 6 μM (IC50) and with OPN siRNA for MTT assay and colony forming assay...
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361854/anti-histone-h1-iggs-possess-proliferative-activity-towards-human-t-leukaemia-cem-cells
#13
Y Kit, I Magorivska, R Bilyi, S Myronovskij, R Stoika
The aim of this study was to characterize the proliferative activity of the anti-histone H1 IgGs towards human T-leukaemia CEM cells. MATERIALS AND METHODS: Anti-histone H1 IgGs were purified from blood serum of systemic lupus erythematosus patients by precipitation of serum proteins with 50% ammonium sulfate followed by a sequential affinity chromatography on Protein G-Sepharose and histone H1-Sepharose columns. To avoid contamination with other proteins, anti-histone H1 IgGs were subjected to strongly acidic pH 2...
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361853/anticancer-effect-and-immunologic-response-to-xenogeneic-embryonic-proteins-in-mice-bearing-ehrlich-solid-carcinoma
#14
T V Symchych, N I Fedosova, О М Karaman, L M Yevstratieva, H P Potebnia
AIM: To investigate anticancer and immunologic effects of chicken embryonic proteins (CEP) in mice bearing Ehrlich solid carcinoma. MATERIALS AND METHODS: The study was carried out on male Balb/c mice bearing Ehrlich solid carcinoma. The immunizations were performed after the tumor transplantation. The immune status was assessed on days 7, 14, 21 and 28 after the tumor challenge. Cytotoxic activity (CAT) of macrophages (Mph), natural killer cells (NK), cytotoxic T-lymphocytes (CTL) and blood serum, as well as the influence of the blood serum on immune cells activity was checked in MTT-assay; Mph's cytochemical activity was tested in NBT-assay; Ehrlich antigen-specific or CEP-specific antibodies were detected in ELISA-assay; medium size circulating immune complexes (CIC) were detected in reaction of 4...
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361852/epr-spectroscopy-studies-of-changes-in-erythrocyte-membranes-in-patients-with-laryngeal-cancer
#15
Y B Burlaka, O V Sukhoveev, N V Grin, O M Khilchevskyi, S V Verevka
AIM: To evaluate microviscosity and sorption capacity of erythrocyte membranes (SCEM) from patients with laryngeal cancer (LC). MATERIALS AND METHODS: Samples from 35 patients with LC of stages II and III and 20 healthy volunteers were investigated by electron paramagnetic resonance with Bis(1-oxyl-2,2,6,6-tetramethylpiperidinyl-4)-ester of 5,7-dimethyladamantane-1,3-dicarbonic acid (AdTEMPO) probe. SCEM was evaluated by amount of unabsorbed methylene blue. RESULTS: Microviscosity of erythrocyte membranes was determined by the effective rotational diffusion correlation times (τeff) and a decrease in radical spectrum signal intensity per hour...
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361851/significance-of-iodine-symporter-for-prognosis-of-the-disease-course-and-efficacy-of-neoadjuvant-chemotherapy-in-patients-with-breast-cancer-of-luminal-and-basal-subtypes
#16
V F Chekhun, A V Andriiv, N Yu Lukianova
The aim of the research was to study the relation between expression of Na.
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361850/prognostic-value-of-the-bone-turnover-markers-in-multiple-myeloma
#17
D Auzina, R Erts, S Lejniece
BACKGROUND: Multiple myeloma (MM) is characterized by osteolytic bone disease resulting from increased osteoclast activity and reduced osteoblast function. AIM: The aim of our research was to determine connection between bone turnover markers and presence of bone lesions, their degree of severity, to monitor MM bone disease and to assess effectiveness of anti-myeloma treatment. MATERIALS AND METHODS: Serum samples and clinical data from 123 patients with newly diagnosed MM were collected at Riga East Clinical University Hospital (Riga, Latvia) from June 2014 to June 2016...
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28361849/effect-of-antitumor-drugs-in-low-concentrationson-the-biological-immunophenotypic-and-cytogenetic-characteristics-of-human-colon-cancer-cells-in-vitro
#18
N Bezdenezhnykh, O Kovalova, O Lykhova, R Kocherga, A Vorontsova, V Zhylchuk, G I Maksimyak, Yu Kudryavets
OBJECTIVE: To estimate the impact of the low-dose anticancer drugs (ACD) with the different mechanisms of action and human interferon (IFN) alpha 2b on the biological properties, immunophenotypic and cytogenetic characteristics of colon cancer cells in vitro. MATERIALS AND METHODS: The study was performed on human colon cancer cell lines COLO 205, HT-29 and 3C-P treated with ACD and IFN in subtoxic concentrations. Expression of CD44, N-cadherin, vimentin, β-catenin, ERCC1 and Slug was assessed by immunocytochemical method...
March 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28230833/foreword-to-the-special-issue-the-chornobyl-nuclear-accident-thirty-years-after
#19
(no author information available yet)
No abstract text is available yet for this article.
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28230832/specific-interactions-between-lectins-and-red-blood-cells-of-chornobyl-cleanup-workers-as-indicator-of-some-late-radiation-effects
#20
I S Karpova
AIM: Growing interest in lectins is based on their diagnostic and pharmacological potential, especially the ability to inhibit proliferation and initiate apoptosis of cancer cells. In our research microplate lectinoassay able to detect carbohydrate containing structures (receptors) on erythrocyte surface have been proposed for Chornobyl cleanup workers (1986) monitoring. It was expected to reveal specific abnormalities associated with pathological condition arising as a result of late radiation effects...
December 2016: Experimental Oncology
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