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Experimental Oncology

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https://www.readbyqxmd.com/read/27685534/information
#1
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27685533/yevhenii-petrovych-sidorik-1931-2016
#2
(no author information available yet)
Professor Yevhenii Petrovych Sidorik, well-known scientist in the fields of biophysics and experimental oncology, double Laureate of the State Prize in Science and Technology, Laureate of O.O. Bohomolets Prize and R.E. Kavetsky Prize of the NAS of Ukraine died on the 86(th) year of his life.
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27685532/a-rare-clinical-case-of-the-isolated-primary-frontal-bone-osteoma
#3
Kh Pohranychna
AIM: To study a rare clinical case of isolated primary osteoma localized in the frontal bone, provide its detailed clinical and pathomorphological analysis, and evaluate statistical indicators of occurrence frequency and localization of facial skeleton osteomas during 2006-2015. MATERIALS AND METHODS: The retrospective case records analysis of patients undergoing treatment in the ma-xillofacial department of Lviv Regional Clinical Hospital and suffering from facial skeleton osteomas was conducted...
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27685531/accessory-spleen-hypertrophy-mimicking-colon-cancer-metastasis
#4
I Ates, O Yazici, D Yazilitas, N Ozdemir, N Zengin
Accessory spleen is a congenital form of an ectopic splenic tissue. In this report, we present a case of a patient who was followed with the diagnosis of rectal and sigmoid colon cancer and an accessory spleen hypertrophy, which was thought to be colon cancer metastasis in the left hypochondriac region. After colectomy and splenectomy, accessory spleen that mimics cancer metastasis was diffrentially diagnosed using scintigraphy.
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27685530/metastasis-of-two-malignant-tumors-of-different-genesis-in-axillary-lymph-node-a-case-report
#5
A V Rusin, O V Petrosov, A I Chumak, V M Kushnir
This case report describes a rare clinical condition: metastasis of synchronous multiple primary tumors - skin melanoma and breast cancer in one axillary lymph node, confirmed with the results of clinical, morphological and immunohistochemical study of surgical material from 40 year-old woman.
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27685529/chronic-myeloid-leukemia-in-patient-with%C3%A2-the%C3%A2-klinefelter-syndrome
#6
S V Andreieva, K V Korets, O A Kyselova, O E Ruzhinska, I M Serbin
AIM: Genetic inborn along with acquired diseases arise due to the lesions in genome of multipotent hematopoietic stem cells. The aim was to study an influence of constitutional anomaly, Klinefelter syndrome, and additional structural rearrangements on the BCR-ABL tyrosine kinase inhibitor targeted therapy efficacy. MATERIAL AND METHODS: We describe a 32-year-old male patient with chronic myeloid leukemia (CML) who was detected to have sex chromosomal abnormality during evaluation for Philadelphia chromosome...
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27685528/the-effect-of-%C3%AF-fatty-acids-on-mrna-expression-level-of-ppar%C3%AE-in-patients-with-gastric-adenocarcinoma
#7
A Hosseinzadeh, M-H Somi, H Dolatkhah, A Esfahani, H S Kafil, S M Ardebili
BACKGROUND: The antineoplastic role of peroxisome proliferator-activated receptor gamma (PPARγ) ligandshas previously been demonstrated in several gastric cancer cell lines. Activation of PPARγ by polyunsaturated fatty acids (PUFAs) inhibits growth and proliferationof tumor cells. In this double-blind clinical study, we evaluate the effect of PUFAs on PPARγ mRNA expression in patients with gastric adenocarcinoma. MATERIALS AND METHODS: A total of 34 chemotherapy-naive patients diagnosed with gastric adenocarcinoma were enrolled in the present study...
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27685527/the-efficacy-of-tissue-factor-603a-g-and-5466a-g-polimorphisms-at-the-development-of-venous-thromboembolism-in-cancer-patients
#8
A Eroğlu, G G Ceylan, E Ozturk, A Yalcin, B Yalcin, D Karasoy
UNLABELLED: Venous thromboembolism (VTE) is one of the most common complications in cancer patients. Although factor V Leiden (FVL) is the most common genetic defect causing thrombosis, the impact of gene abnormalities on thrombotic tendency in cancer patients remains poorly explored. Tissue factor (TF) is a major physiologic initiator of blood coagulation. This is the first study regarding the association of TF gene -603A/G and +5466A>G polymorphisms with VTE in malignancy. Materials and Me-thods: The study consists of two groups: cancer patients with VTE were included as Group 1 (n = 46); Group 2 comprises 196 cancer patients without VTE...
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27685526/lactoferrin-expression-in-breast-cancer-in-relation-to-biologic-properties-of-tumors-and-clinical-features-of-disease
#9
L A Naleskina, N Yu Lukianova, S O Sobchenko, D M Storchai, V F Chekhun
UNLABELLED: To determine the patterns of lactoferrin (LF) expression in breast cancer (BC) in relation to biologic properties of the neoplasms and clinical features of the disease course. MATERIALS AND METHODS: Clinical specimens of 266 BC patients (115 patients with BC of stages I-II - retrospective study, and 151 BC patients - prospective study) were analyzed. Morphological, immunohistochemical and statistical methods were used. RESULTS: The number of LF-positive tumors in retrospective and prospective groups was similar (52...
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27685525/2-deoxy-d-glucose-enhances-dichloroacetate-antitumor-action-against-lewis-lung-carcinoma
#10
O N Pyaskovskaya, D L Kolesnik, A G Fedorchuk, I V Prokhorova, G I Solyanik
UNLABELLED: Aerobic glycolysis that supports high proliferation rate and survival of tumor cells in unfavorable conditions is among fundamental features of tumor metabolism. The search for active modulators of energetic metabolism capable of suppressing tumor growth and metastasis could result in higher effectiveness of anticancer therapy. AIM: To study antitumor and antimetastatic activity of the modulators of energetic metabolism dichloroacetate (DCA) and 2-deoxy-D-glucose (2DG) used in combination treatment of Lewis lung carcinoma (LLC)...
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27685524/enterosorption-combined-with-granulocyte-colony-stimulating-factor-decreases-melphalan-gonadal-toxicity
#11
O O Shevchuk, Ya Ya Bodnar, K I Bardakhivskaya, T V Datsko, A S Volska, К А Posokhova, V F Chekhun, V G Nikolaev
UNLABELLED: Today due to improvements in cancer treatment there is an increasing number of long-term cancer survivors, many of whom suffer from infertility caused by malignancy itself and chemo- or radiotherapy. Also, anticancer therapy may cause myelosuppression. Presently granulocyte colony stimulating factor (G-CSF) is used for prevention and treatment of myelosuppression. Another treatment option used to decrease intoxication and ameliorate side effects of cancer therapy is sorption technology...
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27685523/correlation-of-iodine-symporter-expression-in-highly-and-low-malignant-cell-lines-of-human-breast-cancer-differed-in-their-sensitivity-to-doxorubicin
#12
N Yu Lukianova, A V Andriiv, V F Chekhun
UNLABELLED: To investigate the relationship of sodium/iodide symporter (NIS) expression with molecular phenotype of highly and low malignant cell lines of human breast cancer (BC) with different sensitivity to doxorubicin (Dox). MATERIALS AND METHODS: The cell lines used in the analysis included T47D, MCF-7, MDA-MB-231, MDA-MB-468, and MCF/Dox. NIS expression was studied by immunocytochemical method. RESULTS: The strongest iodine symporter expression (248 ± 1...
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27685522/insights-into-the-mechanism-of-natural-terpenoids-as-nf-%C3%AE%C2%BAb-inhibitors-an-overview-on-their-anticancer-potential
#13
H Jain, N Dhingra, T Narsinghani, R Sharma
The transcription factor, nuclear factor kappa B (NF-kB) is one of the principal inducible protein in mammals known to control the gene expression in many critical physiological responses such as oxidative stress, inflammation etc. and has been shown to play an important role in the pathogenesis of cancer. Terpenoids are major constituents present in nutritionally used fruits, vegetables and different spices which possess various pharmacological action including anticancer activity. Various terpenoids, viz...
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27685521/the-use-of-proteomic-technologies-in-breast-cancer-research
#14
M G Mazur, T V Pyatchanina
The main findings in the field of breast cancer proteomic research as well as modern strategies, technologies and methods of validation are reviewed. A special attention is focused on validated proteomic biomarkers of breast cancer. The data on proteomic profiling of stroma, tumor microenvironment, involvement of proteins in tumor progression, invasion and metastasis, and mechanisms of action of new generation drugs, are analyzed. The results of proteomic analysis are of high clinical importance and significantly improve tumor molecular profiling, stratification of patients, screening, diagnostics, and therapy of breast cancer...
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27356585/nikolai-fedorovich-gamaliya-1932-2016
#15
(no author information available yet)
Professor Nikolai Fedorovich Gamaliya, well-known scientist in the field of laser biomedical research, biophysicist, authority in experimental oncology, Laureate of the State Prize in Science and Techno-logy of Ukraine, Head of the Department of Biological Effects of Ionizing and Non-Ionizing Radiation of R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the National Academy of Sciences (NAS) of Ukraine died on June 14, 2016 at the age of 83.
June 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27356584/daniil-f-gluzman-on-the-80-th-birth-anniversary
#16
(no author information available yet)
In June 2016, Professor Daniil Fishelevich Gluzman, well-known Ukrainian oncohematologist, celebrates his 80(th) anniversary.
June 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27356583/materials-of-international-scientific-conference-integrated-clinical-and-pathogenetic-approaches-in-diagnosis-and-therapy-of-cancer-june-13-15-2016-kyiv-ukraine
#17
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27356582/clinicopathological-features-of-nonspecific-invasive-breast-cancer-according-to-its-molecular-subtypes
#18
(no author information available yet)
UNLABELLED: The aim of the present study was to investigate the clinical and morphological features of nonspecific invasive breast cancer according to its molecular subtypes. MATERIALS AND METHODS: 163 women with nonspecific invasive breast cancer (T1-4N0-3M0) were included in the present study. Luminal A type of breast cancer was detected in 101 women, luminal B type - in 23 women, overexpression of HER2/neu was identified in 14 women and triple-negative cancer - in 25 women...
June 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27356581/the-level-of-igg-antibodies-reactive-to-tf-tn-and-alpha-gal-polyacrylamide-glycoconjugates-in-breast-cancer-patients-relation-to-survival
#19
E P Smorodin, B L Sergeyev
BACKGROUND: The serum levels of IgG antibodies reactive to glycoconjugates (TF, Tn and αGal) were found to be associated with prognosis of gastrointestinal cancer patients. AIM: To study the relation between the levels of serum antibodies to TF-pAA, Tn-PAA and αGal-PAA polyacrylamide-based glycoconjugates and survival in breast cancer. MATERIALS AND METHODS: The preoperative level of IgG antibodies was analysed in the serum of patients (n = 59) using ELISA with polyacrylamide-glycoconjugates namely, TF-pAA (amide-type), and ethanolamide-conjugates Tn-PAA and αGal-PAA...
June 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27356580/detection-of-notch1-c-7541_7542delct-mutation-in-chronic-lymphocytic-leukemia-using-conventional-and-real-time-polymerase-chain-reaction
#20
N I Bilous, I V Abramenko, A A Chumak, I S Dyagil, Z V Martіna
UNLABELLED: To evaluate real-time polymerase chain reaction (PCR) assay system for detection of NOTCH1 c.7541_754delCT mutation in chronic lymphocytic leukemia (CLL) patients. MATERIAL AND METHODS: A total of 325 CLL patients were included in the study. Screening for NOTCH1 c.7544_7545delCT was performed using conventional PCR-based amplification refractory mutation system (ARMS) method. All 33 samples harboring c.7544_7545delCT allele and 5 negative cases as control were submitted to real-time PCR...
June 2016: Experimental Oncology
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