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Experimental Oncology

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https://www.readbyqxmd.com/read/29949539/down-regulation-of-u-pa-by-a-nutrient-mixture-in-hemangioma-eoma-cells-by-inducing-caspase-dependent-apoptosis
#1
M W Roomi, B Bhanap, A Niedzwiecki, M Rath
Hemangiomas are the most common congenital vascular and benign tumor in infants and children. Most hemangiomas do not cause major symptoms to require intervention, however, the larger hemangiomas have tendency to bleed and may require surgical removal. Experimental studies have demonstrated the role of urokinase plasminogen activator (u-PA), especially cell surface u-PA, as an initiator of extra-cellular matrix proteolysis and associated tumor cell invasion. AIM: To examine, whether the antitumor effects of a specific nutrient mixture are due to induction of apoptosis by inhibition of u-PA...
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29949538/effect-of-valproic-acid-in-comparison-with-vorinostat-on-cell-growth-inhibition-and-apoptosis-induction-in-the-human-colon-cancer-sw48-cells-in-vitro
#2
M Sanaei, F Kavoosi, O Mansoori
AIM: Acetylation levels of histones are the result of the balance between histone acetyltransfrases and histone deacetylases activities, which plays an important role in chromatin remodeling and regulation of gene expression. Histone deacetylases inhibitors such as valproic acid, vorinostat have attracted interest because of their ability to induce differentiation and apoptosis of cancer cells. The current study was designed to assess the effect of valproic acid in comparison to and in combination with vorinostat on cell growth inhibition and apoptosis induction in the human colon cancer SW48 cells...
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29949537/expression-of-steroid-and-peptide-hormone-receptors-metabolic-enzymes-and-emt-related-genes-in-prostate-tumors-in-relation-to-the-presence-of-the-tmprss2-erg-fusion
#3
G V Gerashchenko, L V Mevs, L I Chashchina, M V Pikul, O P Gryzodub, E O Stakhovsky, V I Kashuba
AIM: To analyze an expression pattern of the steroid and peptide hormone receptors, metabolic enzymes and EMT-related genes in prostate tumors in relation to the presence of the TMPRSS2/ERG fusion; and to examine a putative correlation between gene expression and clinical characteristics, to define the molecular subtypes of prostate cancer. MATERIALS AND METHODS: The relative gene expression (RE) of 33 transcripts (27 genes) and the presence/absence of the TMPRSS2/ERG fusion were analyzed by a quantitative PCR...
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29949536/materials-of-symposium-and-summer-school-fundamental-principles-of-cancer-biotherapy-may-21-23-2018-kyiv-ukraine
#4
(no author information available yet)
No abstract text is available yet for this article.
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29949535/the-analysis-of-methylation-of-dna-promoter-of-sfrp2-gene-in-patients-with-hyperplastic-processes-of-the-endometrium
#5
V G Marichereda, N A Bykovа, V V Bubnov, G S Manasova, T Y Moskalenko, A G Volyanska, I M Shevchenko, T M Adamovska
The hyperplastic processes of the endometrium can arise not only against the background of excessive influence of estrogen, but also against the background of epigenetic damages that affect apoptosis, cell proliferation, differentiation, and adhesion, and DNA reparation. The aim of our study was to investigate and analyze the status of methylation of the promoter of SFRP2 gene in patients with hyperplastic processes of the endometrium. MATERIALS AND METHODS: The study groups were the following: I - patients with endometrial hyperplasia (EH, n = 9); II - patients with endometrial intraepithelial neoplasia (EIN, n = 10), III - control groups: 1) with endometrial cancer (EC, n = 4), and 2) healthy women (n = 4)...
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29949534/increased-homocysteine-plasma-levels-in-breast-cancer-patients-of-a-mexican-population
#6
K M Varela Almanza, A M Puebla-Pérez, J I Delgado-Saucedo, F Rodríguez-Arévalo, G M Zúñiga-González, L E Figuera, A Morán-Mendoza, M P Gallegos-Arreola
AIM: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. MATERIALS AND METHODS: The tHcy plasma levels were measured using high-performance liquid chromatography with a fluorescence detector in 89 female controls and 261 BC patients...
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29949533/lymphocyte-count-in-peripheral-blood-is-a-sensitive-tool-in-pretreatment-assessment-of-patients-with-urological-cancer
#7
P Yakovlev, D Klyushin
Cancer, inflammation and immune surveillance recruit lymphocytes as common key cellular players. The aim of the study was to assess a utility of the absolute and relative lymphocyte counts (ALC and RLC) in peripheral blood of patients with urological cancer as sensitive tool in pretreatment assessment of patient, which correlates with postoperative outcome of the disease, and outlines the overall reactivity of the patient. MATERIALS AND METHODS: We retrospectively studied correlation between lymphocyte count in peripheral blood of the patients with urological cancer (n = 789) and number of clinical parameters: cancer localization, stage of the disease, treatment outcome, complications...
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29949532/anagrelide-and-the-calr-mutation-allele-burden-in-essential-thrombocythemia
#8
E Atkinson, M Bakri, A Hayat, S E Langabeer
No abstract text is available yet for this article.
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29949531/clinical-and-immunohistochemical-features-of-primary-breast-cancer-and-metachronous-ovarian-and-endometrial-tumors
#9
A E Kryzhanivska, I B Dyakiv, I Kyshakevych
The aim of the study was to assess the patterns of development of metachronous cancer (endometrial cancer, EC, and ovarian cancer, OC) in breast cancer (BC) patients dependent of receptor phenotype of breast tumors. MATERIALS AND METHODS: In the study, 63 patients with ВС, who developed metachronous EC (n = 47) or OC (n = 16) were enrolled. Expression of estrogen receptor (ER), progesterone receptor (PR), HER/2neu was assessed using immunohistochemical approach. RESULTS: BC in patients with metachronous EC and OC was characterized by a different frequency of molecular subtypes with the dominance of luminal A (36%) and B (43%) subtypes...
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29949530/differentiated-thyroid-carcinomas-associated-with-chronic-thyroiditis-biological-and-clinical-properties
#10
T M Myshunina, B D Guda, M Yu Bolgov, N I Mikhailenko, N D Tronko
AIM: To determine biological and clinical features of papillary and follicular thyroid carcinomas associated or not associated with chronic thyroiditis. MATERIALS AND METHODS: The study was conducted by retrospective analysis of medical histories of 2,459 patients with thyroid cancer. Tumor size, its category according to the TNM system, multi-focal properties of tumor growth, carcinoma invasiveness, as well as disease stage, rates of relapses and metastasis, and also cumulative survival rates were analyzed...
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29949529/gastric-signet-ring-cell-carcinoma-with-hypersecretion-of-%C3%AE-human-chorionic-gonadotropin-and-review-of-the-literature
#11
W Ben Kridis, R Ben Hassena, S Charfi, N Toumi, T Boudawara, A Khanfir, M Frikha
β-Human chorionic gonadotropin (β-HCG) is an embryonic protein secreted by the syncytiotrophoblast of the placenta. The determination of the plasma β-HCG level is routinely used for the diagnosis and the follow-up of germ cell tumors. Some adenocarcinomas have been described as being rarely associated with β-HCG hypersecretion. We report a case of gastric signet-ring cell carcinoma with β-HCG hypersecretion and propose hypotheses to explain the pathogenesis of such hypersecretion.
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29949528/clinical-case-of-a-patient-undergoing-radium-223-treatment-following-treatment-with-abiraterone-acetate-and-enzalutamide
#12
M E Jiménez Romero, S Díez Farto, J S Navarro Serrato, E Canelón Castillo, I Revelo Cadena
OBJECTIVE: Over the last decade, significant advances have been made in the development of therapies for patients with metastatic castration-resistant prostate cancer. Abiraterone and enzalutamide were approved as treatments based on data supporting improved overall survival compared to placebo. Radium-223 became the first approved radiopharmaceutical which decreased skeletal-related events, palliated pain, and showed improved overall survival in symptomatic patients with castration-resistant prostate cancer and bone metastasis only...
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29949527/intersection-between-genes-controlling-vascularization-and-angiogenesis-in-renal-cell-carcinomas
#13
S Souchelnytskyi
AIM: To show that application of the systemic analysis may significantly improve comparison of different datasets. Different genes and proteins may converge on the same functional outputs. A comparison of 2 datasets by only identification names of affected molecules may miss that, leading to a conclusion that there is nothing in common for these datasets. Systemic analysis may overcome this limitation, by focusing on functions represented by the identification names. MATERIALS AND METHODS: Datasets were retrieved from open sources...
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29949526/the-state-of-bone-metabolism-in-lung-cancer-patients
#14
Y V Dumanskiy, O V Syniachenko, Ph A Stepko, G S Taktashov, O Y Chernyshova, O Y Stoliarova
In recent years, we have discussed the correlation of malignant tumor process with the development of osteoporosis, which can be exacerbated by ongoing chemotherapy and radiation therapy. The aim of the work was to assess the status of bone metabolism in 32 untreated patients with lung cancer without metastasis. MATERIALS AND METHODS: Patients underwent dual-energy X-ray osteodensitometry of proximal part of femoral bone. Osteopontin (OP), osteocalcin (OC) and alkaline phosphatase (AP) parameters were studied in blood, as well as osteo-associated chemical elements...
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29949525/ox40l-gene-polymorphism-and-breast-cancer-in-iranian-population
#15
R Vakil Monfared, F Mashayekhi
BACKGROUND AND AIM: The immune system plays an important role in the breast cancer development. OX40L (also known as TNFSF4), a membrane protein, which is a member of the tumor necrosis factor super family binds to its receptor OX40 and this co-stimulation has a crucial role in T cell proliferation, survival and cytokine release. Previous studies have shown that OX40L is associated with cancer. Due to the importance of the T cells in antitumor activities of OX40L we studied the association of rs3850641 (A→G) polymorphism of OX40L gene with the breast cancer...
June 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29600986/molecular-genetic-models-for-prognosis-of-development-of-tumors-of-reproductive-system-in-women-with-family-history-of-cancer
#16
O V Paliychuk, L Z Polishchuk, Z I Rossokha, V F Chekhun
AIM: To develop a prognostic molecular genetic model for assessing the risk of development of benign and malignant tumors of female reproductive organs (FRO) in patients from cancer-affected families. PATIENTS AND METHODS: The work presents the data on a comprehensive clinical examination of 210 women (90 patients with FRO cancer with aggregation of tumor pathology in families, 65 patients with benign pathology of FRO from cancer-affected families, 55 women - control group of healthy women without family history of cancer)...
March 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29600985/role-of-components-of-microrna-machinery-in-carcinogenesis
#17
R Kian, S Moradi, S Ghorbian
MicroRNAs (miRNAs) are a broad class of non-coding RNAs nearly 21 nucleotides length, which play crucial functions in post-transcriptional gene regulation. These molecules are associated with many developmental and cellular processes in eukaryotic organisms. Current investigation has reported major factors contributing to miRNA biogenesis and has constituted basic principles of miRNA function. More recently, it was confirmed that various miRNAs are clearly implicated in human malignancies, such as lung, breast, ovarian, bladder, colon cancer and other kinds of carcinoma...
March 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29600984/clinical-implications-of-p53-alterations-in-oral-cancer-progression-a-review-from-india
#18
K R Patel, B N Vajaria, R D Singh, R Begum, P S Patel
p53 plays a central role in prevention of normal cell from the development of the malignant phenotype. Somatic alterations (mutations, loss of heterozygosity, deletions) in p53 are a hallmark of most human cancers and cause defects in normal p53 function. However, in the tumors harboring wild-type p53, there are alterations in the regulation of the p53. Thus, understanding why p53 is unable to perform its role as a tumor suppressor in these wild-type tumors is very crucial. Germ-line polymorphisms in p53 are also anticipated to cause measurable disturbance in p53 function...
March 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29600983/sensitivity-to-4-hydroxyestradiol-and-dna-repair-efficiency-in-peripheral-blood-lymphocytes-of-endometrial-cancer-patients
#19
L G Buchynska, O V Brieieva
BACKGROUND: The development of hormone-dependent cancers, including endometrial carcinomas, in great part may be mediated by the genotoxic effects of estrogen metabolites, among which 4-hydroxyestradiol (4OHE2) is characterized by the most prominent DNA-damaging properties. It is assumed that the individual sensitivity to the 4OHE2 may determine the predisposition to endometrial cancer (EС). AIM: To analyze the sensitivity of peripheral blood lymphocytes (PBLs) of EC patients to the 4OHE2 and to evaluate the repair efficiency of 4OHE2-induced DNA damage...
March 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29600982/variant-of-rare-hermansky-pudlak-syndrome-associated-with-granulomatous-colitis-diagnostics-clinical-course-and-treatment
#20
L Y Lozynska, A Plawski, M R Lozynska, I Vytvytskyi, R Y Lozynskyi, N Prokopchuk, B Tretiak
AIM: To study the relationship between the genotype and the phenotype in the patients with Hermansky - Pudlak syndrome (HPS) associated with granulomatous colitis; to monitor clinical course of the disease for adequate treatment, cancer surveillance and genetic counseling. MATERIALS AND METHODS: The diagnosis of HPS is established by physical examination, chest X-ray, computed tomography, endoscopic examination with biopsy, and laboratory tests, including histology, baseline laboratory blood, urine and feces tests, determination of ASCA-C and ANCA antibodies using an ELISA...
March 2018: Experimental Oncology
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