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Expert Opinion on Drug Delivery

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https://www.readbyqxmd.com/read/28165836/future-prospects-for-gene-delivery-systems
#1
Lale Kuşcu, Ali Demir Sezer
Gene therapy is the challenging area of biotechnology. Despite its promise for critical diseases, it has serious safety and efficiency issues, particularly with regards to gene transfer systems. Areas covered: We examined the current situation with gene transfer systems and addressed problems this technology. We then searched patent applications about in the area from the Patentscope online system, the international patent database. We analyzed the data obtained to get a general idea about gene delivery systems designed for future use and assessed approaches for more efficient, safer and valid delivery systems...
February 6, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28128004/long-acting-slow-effective-release-antiretroviral-therapy
#2
Benson Edagwa, JoEllyn McMillan, Brady Sillman, Howard E Gendelman
Advances in long-acting antiretroviral therapy (ART) can revolutionize current HIV/AIDS treatments. We coined the term 'long-acting slow effective release ART' (LASER ART) to highlight the required formulation properties of slow drug dissolution, poor water-solubility, bioavailability, little-to-no off-target toxicities and improved regimen adherence. Drug carrier technologies characterized by high antiretroviral drug (ARV) payloads in a single carrier improve the pharmacokinetic and pharmacodynamic profiles...
February 6, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28117595/lipid-based-carriers-for-controlled-delivery-of-nitric-oxide
#3
Mahmoud A Elnaggar, Ramesh Subbiah, Dong Keun Han, Yoon Ki Joung
Nitric oxide (NO) is crucial for body homeostasis at moderate levels, but cytotoxic at high levels, thus making it a potential candidate for anticancer therapies and antibacterial surface coatings. To date, NO use has been limited due to its very short half-life. Many strategies have been utilized in an attempt to control the half-life of NO, including (but not limited to) lipid-based carriers, due to their biocompatibility and versatility. Areas covered: In this review, we discuss the latest studies that aimed to control the release of NO via a variety of lipid-based delivery carriers, such as liposomes (echogenic and normal) and microbubbles...
February 6, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28151692/oral-liquid-levothyroxine-solves-the-problem-of-tablet-levothyroxine-malabsorption-due-to-concomitant-intake-of-multiple-drugs
#4
Roberto Vita, Flavia Di Bari, Salvatore Benvenga
BACKGROUND: Unlike its tablet (TAB) formulation, liquid L-T4 (LIQ) is directly absorbed in the intestine. The aim of this study was to assess whether LIQ was superior to TAB, such that it would overcome the interference induced by co-ingestion of multiple interfering drugs (ID). METHODS: In this prospective cohort study, we recruited 11 patients with apparent reduced TAB absorption due to ≥2 ID, and switched them to LIQ while maintaining the daily dose and the co-ingestion of the ID...
February 2, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28140682/patient-evaluation-of-the-redesigned-follitropin-alfa-pen-injector
#5
Joan Schertz, Hilary Worton
OBJECTIVES: We aimed to evaluate the overall impressions of learning and subsequent use of the redesigned GONAL-f® (follitropin alfa) pen injector by women with recent or current infertility requiring assisted reproductive technologies (ART) or in vitro fertilization (IVF). METHODS: This was a simulated-use study including 86 women with infertility and 30 fertility nurses. Nurses trained the women on the use of the redesigned pen. The opinions of the women on the pen injector were collected during a questionnaire interview...
January 31, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28132527/current-manufacturing-processes-of-drug-eluting-sutures
#6
Mathilde Champeau, Jean-Michel Thomassin, Thierry Tassaing, Christine Jérôme
Drug-eluting sutures represent the next generation of surgical sutures since they fulfill their mechanical functions but also deliver the drug in their vicinity after implantation. These implants are produced by a variety of manufacturing processes. Areas covered: This review provides an overview of the current manufacturing processes for drug-eluting suture production and discusses their benefits and drawbacks depending on the type of drugs. The mechanical properties and the drug delivery profile of drug-eluting sutures are highlighted since these implants must fulfill both criteria...
January 30, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28121205/multi-layer-microcapsules-fresh-insights-and-new-applications
#7
Alexander S Timin, David J Gould, Gleb B Sukhorukov
No abstract text is available yet for this article.
January 25, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28110560/corrigendum
#8
(no author information available yet)
No abstract text is available yet for this article.
January 23, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28103740/novel-functionalization-strategies-to-improve-drug-delivery-from-polymers
#9
Emanuele Mauri, Simonetta Papa, Maurizio Masi, Pietro Veglianese, Filippo Rossi
The utility of controlled and sustained release of drugs from polymeric systems, both bulk (hydrogels) and colloids (nanoparticles), is a key point that should be addressed. Unfortunately, classic delivery systems are essentially driven by diffusion, which is very quick due to the high concentration gradient present in the body. Area covered: This review provides an overview of functionalization strategies which have been used to reduce release rates by taking advantage of post-polymerization functionalization of polymers...
January 20, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28043165/oromucosal-multilayer-films-for-tailor-made-controlled-drug-delivery
#10
Sandra Lindert, Jörg Breitkreutz
The oral mucosa has recently become increasingly important as an alternative administration route for tailor-made, controlled drug delivery. Oromucosal multilayer films, assigned to the monograph oromucosal preparations in the Ph.Eur. may be a promising dosage form to overcome the requirements related to this drug delivery site. Areas covered: We provide an overview of multilayer films as drug delivery tools, and discuss manufacturing processes and characterization methods. We focus on the suitability of characterization methods for particular requirements of multilayer films...
January 3, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28042707/clinical-experience-with-drug-delivery-systems-as-tools-to-decrease-the-toxicity-of-anticancer-chemotherapeutic-agents
#11
Raul C Maranhão, Carolina G Vital, Thauany M Tavoni, Silvia R Graziani
The toxicity of chemotherapeutic agents, resulting from their low pharmacological index, introduces considerable discomfort and risk to cancer patients. Among several strategies to reduce the toxicity of chemotherapeutic agents, targeted drug delivery is the most promising one. Areas covered: Liposomes, micelles, albumin-based, polymeric, dendritic and lipid core nanoparticles have been used as carriers to concentrate anticancer drugs in neoplastic tissues, and clinical studies of those preparations are reviewed...
January 1, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28005451/nanoparticles-for-the-delivery-of-therapeutic-antibodies-dogma-or-promising-strategy
#12
Flávia Sousa, Pedro Castro, Pedro Fonte, Patrick J Kennedy, Maria Teresa Neves-Petersen, Bruno Sarmento
Over the past two decades, therapeutic antibodies have demonstrated promising results in the treatment of a wide array of diseases. However, the application of antibody-based therapy implies multiple administrations and a high cost of antibody production, resulting in costly therapy. Another disadvantage inherent to antibody-based therapy is the limited stability of antibodies and the low level of tissue penetration. The use of nanoparticles as delivery systems for antibodies allows for a reduction in antibody dosing and may represent a suitable alternative to increase antibody stability Areas covered: We discuss different nanocarriers intended for the delivery of antibodies as well as the corresponding encapsulation methods...
December 29, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27967247/how-are-we-improving-the-delivery-to-back-of-the-eye-advances-and-challenges-of-novel-therapeutic-approaches
#13
Vibhuti Agrahari, Vivek Agrahari, Abhirup Mandal, Dhananjay Pal, Ashim K Mitra
Drug delivery to the back of the eye requires strategic approaches that guarantee the long-term therapeutic effect with patient compliance. Current treatments for posterior eye diseases suffer from significant challenges including frequent intraocular injections of anti-VEGF agents and related adverse effects in addition to the high cost of the therapy. Areas covered: Treatment challenges and promising drug delivery approaches for posterior segment eye diseases, such as age-related macular degeneration (AMD) are summarized...
December 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27892726/design-and-characterization-of-neurodurable-gellan-xanthan-ph-responsive-hydrogels-for-controlled-drug-delivery
#14
Poornima Ramburrun, Pradeep Kumar, Yahya E Choonara, Lisa C du Toit, Viness Pillay
OBJECTIVES: The purpose of this study was to develop novel, porous neurodurable interpenetrating networks of gellan-xanthan hydrogel conduits intercalated with pristine polymethyl methacrylate (PMMA) particles for the sustained and concurrent release of two model compounds: bovine serum albumin (BSA) and diclofenac sodium. METHODS: Hydrogel conduits were synthesized using a thermal-ionic crosslinking mechanism with direct incorporation of PMMA. The 15 formulations, generated using a Box-Behnken experimental design, were analyzed for drug release, swelling, erosion and textural properties...
December 21, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27918209/controlling-in-situ-crystallization-of-pharmaceutical-particles-within-the-spray-dryer
#15
Meng Wai Woo, May Ginn Lee, Soroush Shakiba, Shahnaz Mansouri
Simultaneous solidification and in situ crystallization (or partial crystallization) of droplets within the drying chamber are commonly encountered in the spray drying of pharmaceuticals. The crystallinity developed will determine the functionality of the powder and its stability during storage. This review discusses strategies that can be used to control the in situ crystallization process. Areas covered: The premise of the strategies discussed focuses on the manipulation of the droplet drying rate relative to the timescale of crystallization...
December 20, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27935765/gb3-binding-lectins-as-potential-carriers-for-transcellular-drug-delivery
#16
Stefan K Müller, Isabel Wilhelm, Thomas Schubert, Katharina Zittlau, Anne Imberty, Josef Madl, Thorsten Eierhoff, Roland Thuenauer, Winfried Römer
OBJECTIVES: Epithelial cell layers as well as endothelia forming the blood-brain barrier can drastically reduce the efficiency of drug targeting. Our goal was to investigate lectins recognizing the glycosphingolipid globotriaosylceramide (Gb3) for their potential as carriers for transcytotic drug delivery. METHODS: We utilized an in vitro model based on Madin-Darby canine kidney cells transfected with Gb3 synthase to characterize transcytosis of the Gb3-binding lectins LecA from Pseudomonas aeruginosa and the B-subunit of Shiga toxin (StxB)...
December 16, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27935334/antiretroviral-drug-loaded-nanoparticles-in-films-a-new-option-for-developing-vaginal-microbicides
#17
José das Neves, Bruno Sarmento
No abstract text is available yet for this article.
December 14, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27892713/hydrophobic-ion-pairing-as-a-strategy-to-improve-drug-encapsulation-into-lipid-nanocarriers-for-the-cancer-treatment
#18
Mariana Silva Oliveira, Gisele Castro Assis Goulart, Lucas Antônio Miranda Ferreira, Guilherme Carneiro
Incorporation of anticancer drugs with low lipophilicity in lipid nanocarriers is usually low, which limits the utilization of this strategy in cancer therapy. However, the complexation of these drugs with lipophilic ion pairs containing ionizable groups has been reported to improve their incorporation in nanocarriers such as solid lipid nanoparticles (SLNs), nanostructured lipid nanocarriers (NLCs), and nanoemulsions (NEs). Therefore, those nanocarriers have shown an increase in efficacy and lower toxicity compared with the free drugs, particularly if the counter ion utilized has anticancer activity...
December 14, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27892760/microbubble-mediated-ultrasound-drug-delivery-and-therapeutic-monitoring
#19
Charles A Sennoga, Emma Kanbar, Laurent Auboire, Paul-Armand Dujardin, Damien Fouan, Jean-Michel Escoffre, Ayache Bouakaz
Recent developments in ultrasound imaging and ultrasound contrast agents (UCAs) improved diagnostic confidence in echography and set into motion their combined use as a tool for drug delivery and therapeutic monitoring. Non-invasive, precise and targeted delivery of drug molecules to pathological tissues by employing different mechanisms of drug release is becoming feasible. Areas covered: We sought to describe: the nature and features of UCAs; outline current contrast-specific imaging modes; before describing a variety of strategies for using ultrasound and microbubbles as a drug delivery system...
December 11, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27892757/basic-principles-and-current-status-of-transcorneal-and-transscleral-iontophoresis
#20
Taís Gratieri, Verena Santer, Yogeshvar N Kalia
Iontophoresis is an active non-invasive drug delivery technique that can increase the transport of charged and neutral molecules into and across biological membranes. Most research to-date has focused on (per)cutaneous iontophoretic drug delivery. However, recent studies illustrate its potential for drug delivery to the eye: corneal iontophoresis may enable targeted topical therapy of intracorneal diseases, whereas transscleral iontophoresis may enable non-invasive intraocular drug delivery. Areas covered: We describe iontophoretic principles in the context of ocular delivery before providing a summary of recent preclinical studies involving transcorneal and transscleral iontophoresis in vitro and in vivo...
December 11, 2016: Expert Opinion on Drug Delivery
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