journal
MENU ▼
Read by QxMD icon Read
search

Expert Opinion on Drug Delivery

journal
https://www.readbyqxmd.com/read/28819992/insulin-delivery-and-nocturnal-glucose-control-in-children-and-adolescents-with-type-1-diabetes
#1
Martin Tauschmann, Roman Hovorka
Nocturnal glucose control remains challenging in children and adolescents with type 1 diabetes due to highly variable overnight insulin requirements. The issue may be addressed by glucose responsive insulin delivery based on real-time continuous glucose measurements. Areas covered: This review outlines recent developments of glucose responsive insulin delivery systems from a paediatric perspective. We cover threshold-based suspend application, predictive low glucose suspend, and more advanced single hormone and dual-hormone closed-loop systems...
August 18, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28749188/enteric-coatings-for-colonic-drug-delivery-state-of-the-art
#2
Alessandra Maroni, Saliha Moutaharrik, Lucia Zema, Andrea Gazzaniga
No abstract text is available yet for this article.
August 4, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28774208/moving-beyond-subcutaneous-insulin-the-application-of-adjunctive-therapies-to-the-treatment-of-type-1-diabetes
#3
Kathleen H Ang, Jennifer L Sherr
With the discovery of insulin nearly a century ago, the diagnosis of Type 1 Diabetes (T1D) transformed from a death sentence to a chronic medical condition. Despite the advances that have been made, the vast majority of those living with T1D still struggle to achieve targeted control. Yet, a plethora of agents have been developed to treat those with Type 2 Diabetes. Exploration of how these agents may benefit those with T1D has been an area of intense investigation, especially due to the overweight/obesity epidemic, which now afflicts more than 60% of those living with T1D...
August 3, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28771375/recent-development-and-biomedical-applications-of-self-healing-hydrogels
#4
Yinan Wang, Christian K Adokoh, Ravin Narain
Hydrogels are of special importance, owing to their high-water content and various applications in biomedical and bio-engineering research. Self-healing properties is a common phenomenon in living organisms. Their endowed property of being able to self-repair after physical/chemical/mechanical damage to fully or partially its original properties demonstrates their prospective therapeutic applications. Due to complicated preparation and selection of suitable materials, the application of many host-guest supramolecular polymeric hydrogels are so limited...
August 3, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28696796/lng-ius-12-a-19-5-levonorgestrel-releasing-intrauterine-system-for-prevention-of-pregnancy-for-up-to-five-years
#5
Anita L Nelson
Globally, intrauterine devices (IUDs) are the second most commonly used form of reversible contraception because of their high efficacy, safety, convenience and cost effectiveness. The levonorgestrel releasing intrauterine system with daily average release of 20 mcg (LNG-IUS 20) is the popular choice because of its favorable bleeding patterns and many noncontraceptive benefits. A three year (LNG-IUS 8) became available three years ago. More recently, the LNG-IUS 12 was added. This new IUD shares a smaller frame, narrow inserter and lower rate of amenorrhea with the LNG-IUS 8, but it offers the five years of contraceptive protection of the LNG-IUS 20...
August 2, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28749739/nanomedicine-formulations-for-the-delivery-of-antiviral-drugs-a-promising-solution-for-the-treatment-of-viral-infections
#6
David Lembo, Manuela Donalisio, Andrea Civra, Monica Argenziano, Roberta Cavalli
Viral infections represent a public health problem and one of the leading causes of global mortality. Nanomedicine strategies can be considered a powerful tool to enhance the effectiveness of antiviral drugs, often associated with solubility and bioavailability issues. Consequently, high doses and frequent administrations are required, resulting in adverse side effects. To overcome these limitations, various nanomedicine platforms have been designed. Area covered. This review focuses on the state of the art of organic-based nanoparticles for the delivery of approved antivirals...
July 27, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28662354/overview-on-zein-protein-a-promising-pharmaceutical-excipient-in-drug-delivery-systems-and-tissue-engineering
#7
Gihan Labib
Natural pharmaceutical excipients have been applied extensively in the past decades owing to their safety and biocompatibility. Zein, a natural protein of plant origin offers great benefit over other synthetic polymers used in controlled drug and biomedical delivery systems. It was used in a variety of medical fields including pharmaceutical and biomedical drug targeting, vaccine, tissue engineering, and gene delivery. Being biodegradable and biocompatible, the current review focuses on the history and the medical application of zein as an attractive still promising biopolymer...
July 6, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28643528/modulating-release-of-ranibizumab-and-aflibercept-from-thiolated-chitosan-based-hydrogels-for-potential-treatment-of-ocular-neovascularization
#8
Miguel Moreno, Poh Yih Pow, Tan Su Teng Tabitha, Sonali Nirmal, Andreas Larsson, Krishna Radhakrishnan, Jayabalan Nirmal, Soo Tng Quah, Susana Geifman Shochat, Rupesh Agrawal, Subbu Venkatraman
BACKGROUND: This paper describes the synthesis of thiolated chitosan-based hydrogels with varying degrees of crosslinking that has been utilized to modulate release kinetics of two clinically relevant FDA-approved anti-VEGF protein drugs, ranibizumab and aflibercept. These hydrogels have been fabricated into disc shaped structures for potential use as patches on ocular surface. METHODS: Protein conformational changes and aggregation after loading and release was evaluated by circular dichroism (CD), steady-state tryptophan fluorescence spectroscopy, electrophoresis and size-exclusion chromatography (SEC)...
July 3, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28627940/delivery-of-drugs-growth-factors-genes-and-stem-cells-via-intrapericardial-epicardial-and-intramyocardial-routes-for-sustained-local-targeted-therapy-of-myocardial-disease
#9
M G Katz, A S Fargnoli, R J Hajjar, C R Bridges
No abstract text is available yet for this article.
June 22, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28485988/doxycycline-hydrochloride-metronidazole-solid-lipid-microparticles-gels-for-treatment-of-periodontitis-development-in-vitro-and-in-vivo-clinical-evaluation
#10
Heba A Gad, Amany O Kamel, Ola M Ezzat, Hadir F El Dessouky, Omaima A Sammour
OBJECTIVE: To formulate solid lipid microparticles (SLMs) encapsulating doxycycline hydrochloride (DH) and metronidazole (MT) for the treatment of periodontal diseases. METHODS: SLMs were prepared applying hot homogenization method, using different types of lipids and stabilized with various types and concentrations of surfactants. The optimized formula was subjected to freeze-drying followed by incorporation into poloxamer gel. Microbiological and clinical evaluation of the selected SLMs on patients suffering from periodontal diseases was performed...
May 29, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27911116/finding-the-right-route-for-insulin-delivery-an-overview-of-implantable-pump-therapy
#11
Lia Bally, Hood Thabit, Roman Hovorka
Implantable pump therapy adopting the intraperitoneal route of insulin delivery has been available for the past three decades. The key rationale for implantable pump therapy is the restoration of the portal-peripheral insulin gradient of the normal physiology. Uptake in clinical practice is limited to specialized centers and selected patient populations. Areas covered: Implantable pump therapy is discussed, including technical aspects, rationale for its use, and glycemic and non-glycemic effects. Target populations, summaries of clinical studies and issues related to implantable pump therapy are highlighted...
September 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27897039/use-of-nanotechnology-for-improved-pharmacokinetics-and-activity-of-immunogenic-cell-death-inducers-used-in-cancer-chemotherapy
#12
Martyna Janicka, Jerzy Gubernator
Immunogenic cell death inducers (ICD inducers) are a diverse group of therapeutic molecules capable of eliciting an adaptive immune response against the antigens present on the surface of dying cancer cells. Most of these molecules suffer from low bioavailability, high toxicity and poor pharmacokinetics which limit their application. It is believed that nanotechnology, in particular nano-sized nanocarriers, can address most of the issues that limit the use of ICD inducers. Area covered: The mechanism of action of ICD inducers and their limitations is discussed...
September 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27892760/microbubble-mediated-ultrasound-drug-delivery-and-therapeutic-monitoring
#13
Charles A Sennoga, Emma Kanbar, Laurent Auboire, Paul-Armand Dujardin, Damien Fouan, Jean-Michel Escoffre, Ayache Bouakaz
Recent developments in ultrasound imaging and ultrasound contrast agents (UCAs) improved diagnostic confidence in echography and set into motion their combined use as a tool for drug delivery and therapeutic monitoring. Non-invasive, precise and targeted delivery of drug molecules to pathological tissues by employing different mechanisms of drug release is becoming feasible. Areas covered: We sought to describe: the nature and features of UCAs; outline current contrast-specific imaging modes; before describing a variety of strategies for using ultrasound and microbubbles as a drug delivery system...
September 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27892757/basic-principles-and-current-status-of-transcorneal-and-transscleral-iontophoresis
#14
Taís Gratieri, Verena Santer, Yogeshvar N Kalia
Iontophoresis is an active non-invasive drug delivery technique that can increase the transport of charged and neutral molecules into and across biological membranes. Most research to-date has focused on (per)cutaneous iontophoretic drug delivery. However, recent studies illustrate its potential for drug delivery to the eye: corneal iontophoresis may enable targeted topical therapy of intracorneal diseases, whereas transscleral iontophoresis may enable non-invasive intraocular drug delivery. Areas covered: We describe iontophoretic principles in the context of ocular delivery before providing a summary of recent preclinical studies involving transcorneal and transscleral iontophoresis in vitro and in vivo...
September 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27892730/delivery-of-therapeutic-rna-cleaving-oligodeoxyribonucleotides-deoxyribozymes-from-cell-culture-studies-to-clinical-trials
#15
Alesya A Fokina, Boris P Chelobanov, Masayuki Fujii, Dmitry A Stetsenko
Development of efficient in vivo delivery systems remains a major challenge en route to clinical application of antisense technology, including RNA-cleaving molecules such as deoxyribozymes (DNAzymes). The mechanisms of oligonucleotide uptake and trafficking are clearly dependent on cell type and the type of oligonucleotide analogue. It appears likely that each particular disease target would pose its own specific requirements for a delivery method. Areas covered. In this review we will discuss the available options for DNAzyme delivery in vitro and in vivo, outline various exogenous and endogenous strategies that have been, or are still being, developed and ascertain their applicability with emphasis on those methods that are currently being used in clinical trials...
September 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27606669/take-home-naloxone-treatment-for-opioid-emergencies-a-comparison-of-routes-of-administration-and-associated-delivery-systems
#16
Mark J Elzey, Jeffrey Fudin, Eric S Edwards
Naloxone reversal of opioid-induced respiratory depression outside of medical facilities has become more prevalent because of the escalating opioid epidemic in the USA. Take-home naloxone for treatment of opioid emergencies is now being recommended by numerous federal, state, and professional organizations. Areas covered: The scope of the opioid overdose epidemic is reviewed along with practical, clinical, regulatory, and usability considerations for take-home naloxone routes of administration currently available and associated delivery systems...
September 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27892721/social-aspects-in-additive-manufacturing-of-pharmaceutical-products
#17
Johanna Lind, Sofia Kälvemark Sporrong, Susanne Kaae, Jukka Rantanen, Natalja Genina
Additive manufacturing (AM) techniques, such as drug printing, represent a new engineering approach that can implement the concept of personalized medicine via on-demand manufacturing of dosage forms with individually adjusted doses. Implementation of AM principles, such as pharmacoprinting, will challenge the entire drug distribution chain and affect the society at different levels. Areas covered: This work summarizes the concept of personalized medicine and gives an overview of possibilities for monitoring patients' health...
August 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27892717/dental-implants-modified-with-drug-releasing-titania-nanotubes-therapeutic-potential-and-developmental-challenges
#18
Karan Gulati, Sašo Ivanovski
The transmucosal nature of dental implants presents a unique therapeutic challenge, requiring not only rapid establishment and subsequent maintenance of osseointegration, but also the formation of resilient soft tissue integration. Key challenges in achieving long-term success are sub-optimal bone integration in compromised bone conditions and impaired trans-mucosal tissue integration in the presence of a persistent oral microbial biofilm. These challenges can be targeted by employing a drug-releasing implant modification such as TiO2 nanotubes (TNTs), engineered on titanium surfaces via electrochemical anodization...
August 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27892713/hydrophobic-ion-pairing-as-a-strategy-to-improve-drug-encapsulation-into-lipid-nanocarriers-for-the-cancer-treatment
#19
Mariana Silva Oliveira, Gisele Castro Assis Goulart, Lucas Antônio Miranda Ferreira, Guilherme Carneiro
Incorporation of anticancer drugs with low lipophilicity in lipid nanocarriers is usually low, which limits the utilization of this strategy in cancer therapy. However, the complexation of these drugs with lipophilic ion pairs containing ionizable groups has been reported to improve their incorporation in nanocarriers such as solid lipid nanoparticles (SLNs), nanostructured lipid nanocarriers (NLCs), and nanoemulsions (NEs). Therefore, those nanocarriers have shown an increase in efficacy and lower toxicity compared with the free drugs, particularly if the counter ion utilized has anticancer activity...
August 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27881028/corrigendum
#20
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Expert Opinion on Drug Delivery
journal
journal
40792
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"