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Expert Opinion on Drug Delivery

Sahar Gooneh-Farahani, M Reza Naimi-Jamal, Seyed Morteza Naghib
Recently, the use of chitosan (CS) in the drug delivery has reached an acceptable maturity. Graphene-based drug delivery is also increasing rapidly due to its unique physical, mechanical, chemical and electrical properties. Therefore, the combination of CS and graphene can provide a promising carrier for the loading and controlled release of therapeutic agents. Area covered: In this review, we will outline the advantages of this new drug delivery system in association with CS and graphene alone and will list the various forms of these carriers, which have been studied in recent years as drug delivery systems...
December 4, 2018: Expert Opinion on Drug Delivery
Thomas Vangijzegem, Dimitri Stanicki, Sophie Laurent
For many years, the controlled delivery of therapeutic compounds has been a matter of great interest in the field of nanomedicine. Among the wide amount of drug nanocarriers, magnetic iron oxide nanoparticles (IONs) stand out from the crowd and constitute robust nanoplatforms since they can achieve high drug loading as well as targeting abilities stemming from their remarkable properties (magnetic and biological properties). These applications require precise design of the nanoparticles regarding several parameters which must be considered together in order to attain highest therapeutic efficacy...
November 29, 2018: Expert Opinion on Drug Delivery
Whitney Shatz, Jeffrey Aaronson, Stefan Yohe, Robert F Kelley, Yogeshvar N Kalia
Treating posterior eye diseases has become a major area of focus for pharmaceutical and biotechnology companies. Current standard of care for treating posterior eye diseases relies on administration via intravitreal injection. Although effective, this is not without complications and there is great incentive to develop longer-acting therapeutics and/or sustained release delivery systems. Here, we present an overview of emerging technologies for delivery of biologics to the back of the eye. Areas covered: Posterior eye diseases, intravitreal injection, age-related macular degeneration, anti-VEGF, ocular pharmacokinetics, novel technologies to extend half-life, in vivo models, translation to the clinic, hurdles to effective patient care...
November 29, 2018: Expert Opinion on Drug Delivery
Regina Scherließ
Nanoparticles are under discussion in drug delivery for more than 20 years now, but examples for nanoparticulate formulations in the treatment of respiratory diseases are rare and mostly limited to the administration of sub-micron drug particles (ultrafine particles). However, nanoparticles may also carry specific benefits for respiratory treatment. Are nanoparticles the next-generation drug carrier system to facilitate systemic delivery, sustained release and cancer treatment in the lungs? Areas covered: This review will look into the promises and opportunities of the use of nanoparticles in the treatment of respiratory diseases...
November 28, 2018: Expert Opinion on Drug Delivery
P Worth Longest, Karl Bass, Rabijit Dutta, Vijaya Rani, Morgan L Thomas, Ahmad El-Achwah, Michael Hindle
Respiratory drug delivery is a surprisingly complex process with a number of physical and biological challenges. Computational fluid dynamics (CFD) is a scientific simulation technique that is capable of providing spatially and temporally resolved predictions of many aspects related to respiratory drug delivery from initial aerosol formation through respiratory cellular drug absorption. Areas Covered: This review article focuses on CFD-based deposition modeling applied to pharmaceutical aerosols. Areas covered include the development of new complete-airway CFD deposition models and the application of these models to develop a next generation of respiratory drug delivery strategies...
November 21, 2018: Expert Opinion on Drug Delivery
Chinnu Sabu, Panakkal Mufeedha, Kannissery Pramod
Yeast-based drug delivery offers a promising platform for the treatment of various medical conditions. Even the most promising nanoparticulate delivery systems have challenges from gastrointestinal barriers. The novel approach using bio-inspired yeast microcapsule helps in the delivery of charged nanoparticles like quantum dots, iron oxide nanoparticle and various fluorescent nanoparticles. The long-term administration has a good safety profile compared to other delivery systems. Particles can be incorporated into yeast microcapsule by electrostatic interaction, layer-by-layer approach, and surface derivatization...
November 21, 2018: Expert Opinion on Drug Delivery
Nasser Alhajj, Chin Fei Chee, Tin Wui Wong, Noorsaadah Abd Rahman, Noor Hayaty Abu Kasim, Paolo Colombo
Pulmonary drug delivery is organ-specific and benefits local drug action for lung cancer. The use of nanotechnology and targeting ligand enables cellular-specific drug action. Combination approaches increase therapeutic efficacy and reduce adverse effects of cancer chemotherapeutics that have narrow therapeutic index window and high cytotoxicity levels. The current progress of inhaled cancer chemotherapeutics has not been examined with respect to targeting strategy and clinical application potential. Areas covered: This review examines the state of the art in passive (processing and formulation) and active (targeting ligand and receptor binding) technologies in association with the use of nanocarrier to combat lung cancer...
November 13, 2018: Expert Opinion on Drug Delivery
Ayman R Kafal, Donald C Vinh, Mélanie J Langelier
Ready-to-use pre-filled syringes for drug delivery are increasingly used across a broad spectrum of clinical specialties. For patients with primary immunodeficiencies manifesting as antibody deficiencies, immunoglobulin G (IgG) replacement therapy (IgRT) by subcutaneous administration is an established treatment modality. Expanding IgRT administration options through the introduction of pre-filled syringes may further improve its utility. Areas covered: Here, we collate experience with pre-filled syringes from other clinical settings to inform on their practicality and suitability for IgRT...
November 13, 2018: Expert Opinion on Drug Delivery
Sofie Snipstad, Einar Sulheim, Catharina de Lange Davies, Chrit Moonen, Gert Storm, Fabian Kiessling, Ruth Schmid, Twan Lammers
Ultrasound in combination with microbubbles can make cells and tissues more accessible for drugs, thereby achieving improved therapeutic outcomes. In this review, we introduce the term "sonopermeation", covering mechanisms such as pore formation (traditional sonoporation), as well as the opening of tight junctions, stimulated endocytosis/transcytosis, improved perfusion and changes in the stromal compartment. Sonopermeation has gained a lot of interest in recent years, especially for delivering drugs through the otherwise impermeable blood-brain barrier, but also to tumors...
November 12, 2018: Expert Opinion on Drug Delivery
James R Smith, Temidayo O B Olusanya, Dimitrios A Lamprou
The field of nanomedicine, utilising nano-sized vehicles (nanoparticles and nanofibres) for targeted local drug delivery, has a promising future. This is dependent on the ability to analyse the chemical and physical properties of these drug carriers at the nanoscale and hence atomic force microscopy (AFM), a high-resolution imaging and local force-measurement technique, is ideally suited. Areas covered: Following a brief introduction to the technique, the review describes how AFM has been used in selected publications from 2015-2018 to characterise nanoparticles and nanofibers as drug delivery vehicles...
November 10, 2018: Expert Opinion on Drug Delivery
Maha Nasr, Hrushikesh Karandikar, Rasha T A Abdel-Aziz, Noha Moftah, Anant Paradkar
OBJECTIVES: Hot melt extrusion is a continuous process with wide industrial applicability. Till current date, there have been no reports on the formulation of extrudates for topical treatment of dermatological diseases. METHODS: The aim of the present work was to prepare and characterize medicated hot melt extrudates based on Soluplus polymer and nicotinamide, and to explore their applicability in acne treatment. The extrudates were characterized using DSC, FTIR, XRD, and DVS...
November 9, 2018: Expert Opinion on Drug Delivery
Ann Childress, Bernice Ponce De Leon, Mark Owens
Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral disorder affecting as many as 6.4 million children and adolescents in the United States. Since amphetamine (AMPH) and methylphenidate (MPH) were found to be effective more than 60 years ago, numerous formulations of these compounds have been developed. New preparations have focused on convenience, with extended-release (ER) drugs allowing once-daily dosing. Multiple ER formulations do not require patients to swallow a tablet or capsule...
November 7, 2018: Expert Opinion on Drug Delivery
David Altreuter, Ameya R Kirtane, Tyler Grant, Cecilia Kruger, Giovanni Traverso, Andrew Bellinger
The development of oral sustained release dosage forms has been a longstanding goal due to the potential for ease of administration, improved pharmacokinetics, reduced dosing frequency, and improved adherence. The benefits of multi-day single dose drug delivery are evident in the success and patient adoption of injected or implanted dosage forms. However, in the space of oral medications, all current commercially-available gastric resident dosage forms, and most in development, are limited to gastric residence of less than one day...
November 5, 2018: Expert Opinion on Drug Delivery
Andrew R Martin, Charles P Moore, Warren H Finlay
Aerosol drug delivery to the lungs via inhalation is widely used in the treatment of respiratory diseases. The inhalation route is most often used to target delivery to the lungs for local effect, but has also been extensively explored for systemic drug delivery. In either case, the deposition pattern of inhaled particles within the airways of the respiratory tract is key in determining the initial delivered dose. Thereafter, dose-dependent processes including drug release or dissolution, clearance, and absorption influence local and systemic exposure to inhaled drugs over time...
November 2, 2018: Expert Opinion on Drug Delivery
Loïs Morineau, Sophie Chakroun Jacobsen, Karen Kleberg, Harald S Hansen, Christian Janfelt
BACKGROUND: The distribution and metabolism of a drug in the organism are dependent on the administration route as well as on the drug formulation. It is important to be able to assess which impact the administration route or formulation of a drug has for its distribution and metabolism. METHODS: The antidepressant drug amitriptyline was intravenously (IV) dosed to a mouse and immediately after, a similar amount of a deuterium-labeled version of the drug was intraperitoneally (IP) dosed to the same animal...
October 25, 2018: Expert Opinion on Drug Delivery
Hui Yee Chua, Yuan Siang Lui, Ramya Bhuthalingam, Rupesh Agrawal, Tina Wong, Peter Rainer Preiser, Subbu Venkatraman
BACKGROUND: The advent of therapeutic proteins highlights the need for delivery systems that protect and extend the duration of its action. Ranibizumab-VEGF is one such drug used for treating wet AMD. This paper describes a facile method to sustain bioactive ranibizumab release from PLGA-based particles. METHODS: Two emulsion techniques were explored namely: water-in-oil-in-water (WOW) and solid-in-oil-in-water (SOW) emulsion. The bioactivity of ranibizumab was evaluated by comparing its binding capability to VEGF, measured with ELISA to total protein measured by microBCA...
October 25, 2018: Expert Opinion on Drug Delivery
Siddharth S Kesharwani, Shamandeep Kaur, Hemachand Tummala, Abhay T Sangamwar
A major concern that limits the success of cancer chemotherapy is multidrug resistance (MDR). The drug resistance mechanisms are either host related or tumor related. The host tumor interacting factors also contribute to MDR. Multifunctional polymeric micelles offer several advantages in circumventing MDR due to their design, selectivity, and stability in cancer microenvironment. Areas covered: The review is broadly divided into two parts: the first part covers MDR and its mechanisms; the second part covers multifunctional polymeric micelles in combating MDR through its state-of-the-art design...
November 2018: Expert Opinion on Drug Delivery
Antonella Obinu, Elisabetta Gavini, Giovanna Rassu, Marcello Maestri, Maria Cristina Bonferoni, Paolo Giunchedi
Lymphatic vessels are the preferential route of most solid tumors to spread their metastases in the body. Therefore, the individuation and elimination of cancer cells within the lymphatic system (LS) is an important goal. Nanoparticles (NPs), thanks to their small size, represent suitable carriers for imaging and for chemotherapeutic transport to the LS. An update of different nanoparticle delivery systems developed for the detection and treatment of lymphatic metastases has been made, classified from the point of view of the administration routes used...
November 2018: Expert Opinion on Drug Delivery
Basheer Al-Kasmi, Okba Al Rahal, Hind El-Zein, Abdul-Hakim Nattouf
Although many techniques, such as complexation and microencapsulation, are used to mask the unpleasant taste of drugs, the success of all masking processes is evaluated in the same way. To evaluate the success of a masking process, a masked formulation must pass two tests: a structural test and an in vitro in vivo test. Areas covered: This review article highlights structural evaluation and in vitro in vivo evaluation of a taste-masking process. The structural evaluation has two criteria: the absence of any chemical interaction between the drug and the masking agent and the molecular distribution of drug in the network of masking agent...
November 2018: Expert Opinion on Drug Delivery
Khalil Abnous, Noor Mohammad Danesh, Mohammad Ramezani, Fahimeh Charbgoo, Amirhossein Bahreyni, Seyed Mohammad Taghdisi
OBJECTIVES: Here, a novel cruciform DNA nanostructure was developed for targeted delivery of doxorubicin (Dox), as an anticancer agent, to lung (A549 cells) and breast (4T1 cells) cancer cells. The cruciform DNA nanostructure consisted of AS1411 aptamer as targeting agent and Forkhead Box Protein M1(FOXM1) aptamer as therapeutic agent. METHODS: MTT assay, fluorescence imaging, flow cytometry analysis, and in vivoantitumor efficacy were performed to evaluate the function of the Dox-DNA nanostructure complex...
November 2018: Expert Opinion on Drug Delivery
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