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Expert Opinion on Drug Delivery

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https://www.readbyqxmd.com/read/28485988/doxycycline-hydrochloride-metronidazole-solid-lipid-microparticles-gels-for-treatment-of-periodontitis-development-in-vitro-and-in-vivo-clinical-evaluation
#1
Heba A Gad, Amany O Kamel, Ola M Ezzat, Hadir F El Dessouky, Omaima A Sammour
OBJECTIVE: To formulate solid lipid microparticles (SLMs) encapsulating doxycycline hydrochloride (DH) and metronidazole (MT) for the treatment of periodontal diseases. RESEARCH DESIGN & METHODS: SLMs were prepared applying hot homogenization method, using different types of lipids and stabilized with various types and concentrations of surfactants. The optimized formula was subjected to freeze-drying followed by incorporation into poloxamer gel. Microbiological and clinical evaluation of the selected SLMs on patients suffering from periodontal diseases was performed...
May 9, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28423954/the-design-and-scale-up-of-spray-dried-particle-delivery-systems
#2
Ali Al-Khattawi, Andrew Bayly, Andrew Phillips, David Wilson
The rising demand for pharmaceutical particles with tailored physicochemical properties has opened new markets for spray drying especially for solubility enhancement, improving inhalation medicines and stabilization of biopharmaceuticals. Despite this, the spray drying literature is scattered and often does not address the principles underpinning robust development of pharmaceuticals. It is therefore necessary to present clearer picture of the field and highlight the factors influencing particle design and scale-up...
May 4, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28398108/porous-silicon-for-drug-delivery-applications-and-theranostics-recent-advances-critical-review-and-perspectives
#3
Tushar Kumeria, Steven J P McInnes, Shaheer Maher, Abel Santos
Porous silicon (pSi) engineered by electrochemical etching has been used as a drug delivery vehicle to address the intrinsic limitations of traditional therapeutics. Biodegradability, biocompatibility and optoelectronic properties make pSi a unique candidate for developing biomaterials for theranostics and photodynamic therapies. This review presents an updated overview about the recent therapeutic systems based on pSi, with a critical analysis on the problems and opportunities that this technology faces as well as highlighting pSi's growing potential...
April 11, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28388851/dna-rna-based-formulations-for-treatment-of-breast-cancer
#4
Zhaolu Xie, Xianghui Zeng
To develop a successful formulation for the gene therapy of breast cancer, an effective therapeutic nucleic acid and proper delivery system are essential. Increased understanding of breast cancer, and developments in biotechnology, material science and nanotechnology have provided a major impetus in the development of effective formulations for the gene therapy of breast cancer. Areas covered: We discuss DNA/RNA-based formulations that can inhibit the growth of breast cancer cells and control the progress of breast cancer...
April 7, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28388248/the-effects-of-particle-size-shape-density-and-flow-characteristics-on-particle-margination-to-vascular-walls-in-cardiovascular-diseases
#5
Hang T Ta, Nghia P Truong, Andrew K Whittaker, Thomas P Davis, Karlheinz Peter
Vascular-targeted drug delivery is a promising approach for the treatment of atherosclerosis, due to the vast involvement of endothelium in the initiation and growth of plaque, a characteristic of atherosclerosis. One of the major challenges in carrier design for targeting cardiovascular diseases (CVD) is that carriers must be able to navigate the circulation system and efficiently marginate to the endothelium in order to interact with the target receptors. Areas covered: This review draws on studies that have focused on the role of particle size, shape, and density (along with flow hemodynamics and hemorheology) on the localization of the particles to activated endothelial cell surfaces and vascular walls under different flow conditions, especially those relevant to atherosclerosis...
April 7, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28379040/drug-delivery-of-oral-anti-cancer-fluoropyrimidine-agents
#6
Koh Miura, Hiroshi Shima, Naoko Takebe, Julie Rhie, Kennichi Satoh, Yoichiro Kakugawa, Masayuki Satoh, Makoto Kinouchi, Kuniharu Yamamoto, Yasuhiro Hasegawa, Masaaki Kawai, Kousuke Kanazawa, Tsuneaki Fujiya, Michiaki Unno, Ryuichi Katakura
Sixty years since its introduction, 5-FU still forms the core of chemotherapy regimens for many types of malignancies. 5-FU is a time-dependent drug but is rapidly degraded in plasma by dihydropyrimidine dehydrogenase (DPD). Although originally developed in an intravenous form, 5-FU oral prodrugs were developed with the goal of improving efficacy and minimizing toxicity as well as to capitalize on the advantages of oral drug administration. The inactive 5-FU prodrug is gradually converted into the active form in the systemic circulation...
April 5, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28291372/spotlight-on-the-delivery-of-photosensitizers-different-approaches-for-photodynamic-based-therapies
#7
Diogo Silva Pellosi, Priscila da Costa Carvalho De Jesus, Antonio Claudio Tedesco
Nanomedicine development allowed the discovery of new photosensitizers (PS) and drug delivery systems (DDS) to overcome current issues on phototherapy. Nano-engineered materials have the potential to improve the solubility of PS, control drug pharmacokinetics, decreasing side effects, increasing bioavailability, and overcoming multidrug resistance. A recent approach is the co-delivery of PS with other therapeutic agents in a multimodal platform for synergic and improved results. Areas covered: This paper discusses the delivery of PS-nanostructured platforms for conventional, photothermal, and antimicrobial photodynamic therapies, as well as in a recent therapeutic modality for photobiomodulation, covering applications of cancer diagnosis, targeting to skin pathogens, photoregeneration and wound healing...
March 27, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28290714/polymeric-micelles-for-targeted-tumor-therapy-of-platinum-anticancer-drugs
#8
Yuki Mochida, Horacio Cabral, Kazunori Kataoka
Platinum anticancer drugs are effective against a wide range of tumors, though their severe adverse effects and resistance remain unresolved. A breakthrough in these drawbacks could be achieved by using polymeric micelles, i.e. nanoassemblies having a drug loaded core and a protective hydrophilic shell, incorporating platinum drugs for tumor-targeted delivery. Areas covered: The development of cisplatin- (NC-6004) and DACHPt-loaded micelles (NC-4016) has been reviewed, particularly, from the viewpoint of the effect of their structural features on the tumor-targeting efficacy...
March 14, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28286978/seeking-better-topical-delivery-technologies-of-moisturizing-agents-for-enhanced-skin-moisturization
#9
Hyeongmin Kim, Jeong Tae Kim, Sonia Barua, Seung-Yup Yoo, Seong-Chul Hong, Kyung Bin Lee, Jaehwi Lee
An adequate hydration level is essential to maintain epidermal barrier functions and normal physiological activities of skin tissues. Diverse moisturizing agents and pharmaceutical formulations for dermal deliveries have thus extensively been investigated. This review comprehensively discusses scientific outcomes of moisturizing agents and pharmaceutical vehicles for skin moisturization, thereby providing insight into designing innovative pharmaceutical formulations for effective skin moisturization. Areas covered: We discussed the functions of various moisturizing agents ranging from conventional creams to novel moisturizers which has recently been explored...
March 13, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28276966/in-situ-forming-biodegradable-poly-%C3%AE%C2%B5-caprolactone-microsphere-systems-a-challenge-for-transarterial-embolization-therapy-in-vitro-and-preliminary-ex-vivo-studies
#10
Andrea Salis, Elena P Porcu, Elisabetta Gavini, Giulia R Fois, Antonia Icaro Cornaglia, Giovanna Rassu, Marco Diana, Marcello Maestri, Paolo Giunchedi, Ioannis Nikolakakis
BACKGROUND: In situ forming biodegradable poly(ε-caprolactone) (PCL) microspheres (PCL-ISM) system was developed as a novel embolic agent for transarterial embolization (TAE) therapy of hepatocellular carcinoma (HCC). Ibuprofen sodium (Ibu-Na) was loaded on this platform to evaluate its potential for the treatment of post embolization syndrome. METHODS: The influence of formulation parameters on the size/shape, encapsulation efficiency and drug release was investigated using mixture experimental design...
March 1, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28276967/near-infrared-biophotonics-based-nanodrug-release-systems-and-their-potential-application-for-neuro-disorders
#11
Vidya Sagar, Madhavan Nair
Near-infrared ray (NIR)-responsive 'smart' nanoagents allow spatial and temporal control over the drug delivery process, noninvasively, without affecting healthy tissues and therefore they possess high potential for on-demand, targeted drug/gene delivery. Various NIR-responsive drug/gene delivery techniques are under investigation for peripheral disorders (especially for cancer). Nonetheless, their potential not been extensively examined for brain biomedical application. Areas covered: This review focuses on NIR-responsive characteristics of different NIR-nanobiophotonics-based nanoagents and associated drug delivery strategies...
February 28, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28394190/technology-derived-storage-solutions-for-stabilizing-insulin-in-extreme-weather-conditions-i-the-vivicap-1-device
#12
Andreas Pfützner, Gidi Pesach, Ron Nagar
BACKGROUND: Injectable life-saving drugs should not be exposed to temperatures <4°C/39°F or >30°C/86°F. Frequently, weather conditions exceed these temperature thresholds in many countries. Insulin is to be kept at 4-8°C/~ 39-47°F until use and once opened, is supposed to be stable for up to 31 days at room temperature (exception: 42 days for insulin levemir). Extremely hot or cold external temperature can lead to insulin degradation in a very short time with loss of its glucose-lowering efficacy...
June 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28338352/formulation-challenges-for-21st-century-topical-and-transdermal-delivery-systems
#13
Mayank Singhal, Maria Lapteva, Yogeshvar N Kalia
No abstract text is available yet for this article.
June 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28266887/strategies-to-optimize-sirna-delivery-to-hepatocellular-carcinoma-cells
#14
Lucia Scarabel, Francesca Perrone, Marica Garziera, Rossella Farra, Mario Grassi, Francesco Musiani, Concetta Russo Spena, Barbara Salis, Lucia De Stefano, Giuseppe Toffoli, Flavio Rizzolio, Federica Tonon, Michela Abrami, Gianluca Chiarappa, Gabriele Pozzato, Giancarlo Forte, Gabriele Grassi, Barbara Dapas
hepatocellular carcinoma (hcc) is the predominant form of primary liver cancer and the second leading cause of cancer-associated mortality worldwide. available therapies for hcc have limited efficacy due to often late diagnosis and the general resistance of hcc to anti-cancer agents; therefore, the development of novel therapeutics is urgently required. small-interfering rna (sirna) molecules are short, double-stranded rnas that specifically recognize and bind the mrna of a target gene to inhibit gene expression...
June 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27690671/peptides-as-a-therapeutic-avenue-for-nanocarrier-aided-targeting-of-glioma
#15
Mrunal Vitthal Wanjale, G S Vinod Kumar
Very few successful interventions have been possible in glioma therapy owing to its aggressive nature as well as its hindrance of targeted therapy together with the limited access afforded by the blood-brain barrier (BBB). With the advent of nanotechnology based delivery vehicles such as micelles, dendrimers, polymer-based nanoparticles and nanogels, the breach of the BBB has been facilitated. However, there remains the issue of targeted therapy for glioma cells. Peptide-mediated surface modification of nanocarriers serves this purpose, extending the ability to target glioma further than the enhanced permeability and retention effect...
June 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27626885/challenges-and-recent-advances-in-the-subcutaneous-delivery-of-insulin
#16
Xiaohui Guo, Wei Wang
The morbidity of diabetes mellitus is increasing, and subcutaneous injection of exogenous insulin is well established as an effective therapeutic strategy for reducing complications associated with the disease. However, the pain that accompanies repeated injections is an important drawback, and can detrimentally affect the adherence to therapy. Recently, there have been great improvements in injection devices and techniques, including the development of microneedle systems and quantitative injection technologies, which have increased the accuracy of injection, decreased leakage of insulin to the skin surface, and reduced pain...
June 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27606793/modern-drug-delivery-strategies-applied-to-natural-active-compounds
#17
Carmelo Puglia, Maria Rosaria Lauro, Giorgia Giusy Tirendi, Giuseppina Emanuela Fassari, Claudia Carbone, Francesco Bonina, Giovanni Puglisi
Colloidal drug delivery systems (CDDSs) are innovative carriers that have been studied in pharmaceutical field from many years to overcome unfavorable physical and chemical features of synthetic drugs. Recently the use of CDDS as carriers for phytochemicals has seen an exponential increase which, in some cases, has led to the rediscovery of ancient and forgotten natural molecules. Area covered: This article focuses on the main features of CDDS, particularly micro- and nanoemulsions, vesicular carriers and micro- and nanoparticles, loaded with natural active compounds...
June 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27598556/supersaturation-and-crystallization-non-equilibrium-dynamics-of-amorphous-solid-dispersions-for-oral-drug-delivery
#18
Kohsaku Kawakami
Amorphous solid dispersions (ASDs) are one of the key formulation technologies that aid the development of poorly soluble candidates. However, their dynamic behaviors, including dissolution and crystallization processes, are still full of mystery. Further understanding of these processes should enhance their wider use. Areas covered: The first part of this review describes the current understanding of the dissolution of ASDs, where phase separation behavior is frequently involved and attempts to develop appropriate dissolution tests to achieve an in vitro-in vivo correlation are examined...
June 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27589927/pharmacokinetic-profiles-of-cancer-sonochemotherapy
#19
Ying Zhang, Jinyan Li, Tinghe Yu
Sonochemotherapy is a promising strategy for the treatment of cancer, however, there is limited understanding of its pharmacokinetics (PK). Area covered: The PK profile of sonochemotherapy is evaluated based on released data. Preclinical investigations suggest that the blood PK of sonochemotherapy is similar to chemotherapy when using free anticancer drugs. When using encapsulated drugs, a lower plasma level usually occurs; however, the ultrasonic release of drugs within a tumor may lead to drugs leaking into circulation, causing a rebound in the plasma drug level; a higher drug level is detected in certain healthy organs, however this depends mostly on the pharmaceutical formulation...
June 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27575454/recent-advances-in-porous-nanoparticles-for-drug-delivery-in-antitumoral-applications-inorganic-nanoparticles-and-nanoscale-metal-organic-frameworks
#20
Alejandro Baeza, Daniel Ruiz-Molina, María Vallet-Regí
Nanotechnology has provided new tools for addressing unmet clinical situations, especially in the oncology field. The development of smart nanocarriers able to deliver chemotherapeutic agents specifically to the diseased cells and to release them in a controlled way has offered a paramount advantage over conventional therapy. Areas covered: Among the different types of nanoparticle that can be employed for this purpose, inorganic porous materials have received significant attention in the last decade due to their unique properties such as high loading capacity, chemical and physical robustness, low toxicity and easy and cheap production in the laboratory...
June 2017: Expert Opinion on Drug Delivery
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