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Expert Opinion on Drug Delivery

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https://www.readbyqxmd.com/read/29041861/in-vitro-evaluation-of-aerosol-delivery-of-aztreonam-lysine-azli-an-adult-mechanical-ventilation-model
#1
A Rodríguez, M Cabrera, L F Reyes, M Bodí, S Trefler, L Canadell, D Barahona, S Ehrmann, I Martin-Loeches, M I Restrepo, L Vecellio
BACKGROUND: The delivery profile of Aztreonam lysine (AZLI) during mechanical ventilation (MV) is unknown. We evaluated the amount of AZLI drug delivered using an in vitro model of adult MV. METHODS: An adult lung model designed to mimic current clinical practice was used. Both nebulizers were placed before a Y-piece and 4 settings were tested: A) Aeroneb solo® [AS] with a t-piece; B) AS with the spacer; C) M-Neb® [MN] with a t-piece and D) MN with the spacer...
October 18, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29032713/intravenous-iron-treatments-for-iron-deficiency-anemia-in-inflammatory-bowel-disease-a-budget-impact-analysis-of-iron-isomaltoside-1000-monofer-in-the-uk
#2
R F Pollock, G Muduma
Iron deficiency is the leading cause of anemia in patients with inflammatory bowel disease (IBD). Intravenous iron is the first-line treatment for clinically active IBD or previous oral iron intolerance. The aim of the present study was to develop a comparative model of iron deficiency and delivery for iron isomaltoside (IIM), ferric carboxymaltose (FCM), low molecular weight iron dextran (LMWID), and iron sucrose (IS) in the treatment of iron deficiency anemia associated with IBD. Areas covered: A model was developed to evaluate iron delivery characteristics, resource use and costs associated with IIM, FCM, LMWID and IS...
October 16, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28988504/low-colonic-absorption-drugs-risks-and-opportunities-in-the-development-of-oral-extended-release-products
#3
Jin Xu, Yiqing Lin, Pierre Boulas, Matthew L Peterson
Introduction Currently numerous drugs have been observed with lower colonic absorption than small intestine absorption, which can significantly impact in vivo performance of their oral extended release (ER) products. Areas covered We reviewed over 300 publications, patents, book chapters, and commercial reports of drug products from regulatory agencies for low colonic absorption (LCA) drugs and critical findings are discussed. The focuses of this article are (1) current findings on the causes of low colonic absorption to support early assessment of LCA candidates, and (2) current knowledge on successful ER strategies and technical platforms used for LCA drugs in commercial drug products to facilitate oral ER product development...
October 9, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28944694/tissue-plasminogen-activator-based-nanothrombolysis-for-ischemic-stroke
#4
Shan Liu, Xiaozhou Feng, Rong Jin, Guohong Li
Thrombolysis with intravenous tissue plasminogen activator (tPA) is the only FDA approved treatment for patients with acute ischemic stroke, but its use is limited by narrow therapeutic window, selective efficacy, and hemorrhagic complication. In the past two decades, extensive efforts have been undertaken to extend its therapeutic time window and explore alternative thrombolytic agents, but both show little progress. Nanotechnology has emerged as a promising strategy to improve the efficacy and safety of tPA...
September 28, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28918665/considerations-in-establishing-bioequivalence-of-inhaled-compounds
#5
Irvin Mayers, Mohit Bhutani
Generic inhalers are often perceived as inferior to their branded counterparts; however, they are safe and effective if they can meet the regulatory requirements. The approach to assess bioequivalence (BE) in oral dosage form products is not sufficient to address the complexities of inhalational products (e.g., patient-device interface); hence, more considerations are needed and caution should be applied in determining BE of inhaled compounds. Areas covered: This review outlines the evaluation process for generic inhalers, explores the regulatory approaches in BE assessment, and highlights the considerations and challenges in the current in vitro and in vivo approaches (lung deposition, pharmacokinetic, pharmacodynamic/clinical studies, and patient-device interface) for establishing BE of inhaled compounds...
September 21, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28895435/intranasal-delivery-of-stem-cell-based-therapies-for-the-treatment-of-brain-malignancies
#6
Gina Li, Nicolas Bonamici, Mahua Dey, Maciej S Lesniak, Irina V Balyasnikova
Glioblastoma (GBM) is the most aggressive malignant brain cancer in adults, and its poor prognosis and resistance to the existing standard of care require the development of innovative therapeutic modalities. The local delivery of stem cells as therapeutic carriers against glioma has produced encouraging results, but encounters obstacles with regards to the repeatability and invasiveness of administration. Intranasal delivery of therapeutic stem cells could overcome these obstacles, among others, as a noninvasive and easily repeatable mode of administration...
September 12, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28893110/radioimmunotherapy-for-delivery-of-cytotoxic-radioisotopes-current-status-and-challenges
#7
Carlos Daniel Martins, Gabriela Kramer-Marek, Wim J G Oyen
Radioimmunotherapy (RIT) with monoclonal antibodies and their fragments labelled with radionuclides emitting α-particles, β-particles or Auger electrons have been used for many years in the development of anticancer strategies. While RIT has resulted in approved radiopharmaceuticals for the treatment of hematological malignancies, its use in solid tumors still remains challenging. Areas covered: In this review, we discuss the exciting progress towards elucidating the potential of current and novel radioimmunoconjugates and address the challenges for translation into clinical practice...
September 12, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28836459/3d-printing-of-oral-drugs-a-new-reality-or-hype
#8
Wen-Kai Hsiao, Barbara Lorber, Herbert Reitsamer, Johannes Khinast
No abstract text is available yet for this article.
September 5, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28847165/advanced-nanomedicine-for-rheumatoid-arthritis-treatment-focus-on-active-targeting
#9
Minglei Chen, Kambere Amerigos Daddy J C, Yanyu Xiao, Qineng Ping, Li Zong
No abstract text is available yet for this article.
August 29, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28829232/the-role-of-the-solid-state-and-physical-properties-of-the-carrier-in-adhesive-mixtures-for-lung-delivery
#10
Andrea Della Bella, Enrico Salomi, Francesca Buttini, Ruggero Bettini
Direct administration of drugs to the lung is commonly used for the treatment of local respiratory diseases, but it can also be employed to obtain a systemic effect. Besides the advantages offered in terms of higher therapeutic efficacy, this administration route raised specific drug delivery issues. In fact, to obtain a suitable bioavailability and therapeutic effect, the drug has to be efficiently deposited in the lower airways. Formulation is required to render the drug respirable. Area covered. The present paper deals with dry powders formulations, in particular it reviews the literature of the last two decades with respect to the role of the solid-state characteristics of the excipients used as carriers in adhesive mixture toward respirability of the active ingredient...
August 22, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28819992/insulin-delivery-and-nocturnal-glucose-control-in-children-and-adolescents-with-type-1-diabetes
#11
Martin Tauschmann, Roman Hovorka
Nocturnal glucose control remains challenging in children and adolescents with type 1 diabetes due to highly variable overnight insulin requirements. The issue may be addressed by glucose responsive insulin delivery based on real-time continuous glucose measurements. Areas covered: This review outlines recent developments of glucose responsive insulin delivery systems from a paediatric perspective. We cover threshold-based suspend application, predictive low glucose suspend, and more advanced single hormone and dual-hormone closed-loop systems...
August 18, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28749188/enteric-coatings-for-colonic-drug-delivery-state-of-the-art
#12
Alessandra Maroni, Saliha Moutaharrik, Lucia Zema, Andrea Gazzaniga
No abstract text is available yet for this article.
August 4, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28774208/moving-beyond-subcutaneous-insulin-the-application-of-adjunctive-therapies-to-the-treatment-of-type-1-diabetes
#13
Kathleen H Ang, Jennifer L Sherr
With the discovery of insulin nearly a century ago, the diagnosis of Type 1 Diabetes (T1D) transformed from a death sentence to a chronic medical condition. Despite the advances that have been made, the vast majority of those living with T1D still struggle to achieve targeted control. Yet, a plethora of agents have been developed to treat those with Type 2 Diabetes. Exploration of how these agents may benefit those with T1D has been an area of intense investigation, especially due to the overweight/obesity epidemic, which now afflicts more than 60% of those living with T1D...
August 3, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28771375/recent-development-and-biomedical-applications-of-self-healing-hydrogels
#14
Yinan Wang, Christian K Adokoh, Ravin Narain
Hydrogels are of special importance, owing to their high-water content and various applications in biomedical and bio-engineering research. Self-healing properties is a common phenomenon in living organisms. Their endowed property of being able to self-repair after physical/chemical/mechanical damage to fully or partially its original properties demonstrates their prospective therapeutic applications. Due to complicated preparation and selection of suitable materials, the application of many host-guest supramolecular polymeric hydrogels are so limited...
August 3, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28696796/lng-ius-12-a-19-5-levonorgestrel-releasing-intrauterine-system-for-prevention-of-pregnancy-for-up-to-five-years
#15
Anita L Nelson
Globally, intrauterine devices (IUDs) are the second most commonly used form of reversible contraception because of their high efficacy, safety, convenience and cost effectiveness. The levonorgestrel releasing intrauterine system with daily average release of 20 mcg (LNG-IUS 20) is the popular choice because of its favorable bleeding patterns and many noncontraceptive benefits. A three year (LNG-IUS 8) became available three years ago. More recently, the LNG-IUS 12 was added. This new IUD shares a smaller frame, narrow inserter and lower rate of amenorrhea with the LNG-IUS 8, but it offers the five years of contraceptive protection of the LNG-IUS 20...
August 2, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28749739/nanomedicine-formulations-for-the-delivery-of-antiviral-drugs-a-promising-solution-for-the-treatment-of-viral-infections
#16
David Lembo, Manuela Donalisio, Andrea Civra, Monica Argenziano, Roberta Cavalli
Viral infections represent a public health problem and one of the leading causes of global mortality. Nanomedicine strategies can be considered a powerful tool to enhance the effectiveness of antiviral drugs, often associated with solubility and bioavailability issues. Consequently, high doses and frequent administrations are required, resulting in adverse side effects. To overcome these limitations, various nanomedicine platforms have been designed. Area covered. This review focuses on the state of the art of organic-based nanoparticles for the delivery of approved antivirals...
July 27, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28128004/long-acting-slow-effective-release-antiretroviral-therapy
#17
Benson Edagwa, JoEllyn McMillan, Brady Sillman, Howard E Gendelman
Advances in long-acting antiretroviral therapy (ART) can revolutionize current HIV/AIDS treatments. We coined the term 'long-acting slow effective release ART' (LASER ART) to highlight the required formulation properties of slow drug dissolution, poor water-solubility, bioavailability, little-to-no off-target toxicities and improved regimen adherence. Drug carrier technologies characterized by high antiretroviral drug (ARV) payloads in a single carrier improve the pharmacokinetic and pharmacodynamic profiles...
November 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27591122/microneedle-mediated-delivery-of-viral-vectored-vaccines
#18
Marija Zaric, Bárbara Ibarzo Yus, Petya Petrova Kalcheva, Linda Sylvia Klavinskis
Microneedle array platforms are a promising technology for vaccine delivery, due to their ease of administration with no sharp waste generated, small size, possibility of targeted delivery to the specified skin depth and efficacious delivery of different vaccine formulations, including viral vectors. Areas covered: Attributes and challenges of the most promising viral vector candidates that have advanced to the clinic and that have been leveraged for skin delivery by microneedles; The importance of understanding the immunobiology of antigen-presenting cells in the skin, in particular dendritic cells, in order to generate further improved skin vaccination strategies; recent studies where viral vectors expressing various antigens have been coupled with microneedle technology to examine their potential for improved vaccination...
October 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27911116/finding-the-right-route-for-insulin-delivery-an-overview-of-implantable-pump-therapy
#19
Lia Bally, Hood Thabit, Roman Hovorka
Implantable pump therapy adopting the intraperitoneal route of insulin delivery has been available for the past three decades. The key rationale for implantable pump therapy is the restoration of the portal-peripheral insulin gradient of the normal physiology. Uptake in clinical practice is limited to specialized centers and selected patient populations. Areas covered: Implantable pump therapy is discussed, including technical aspects, rationale for its use, and glycemic and non-glycemic effects. Target populations, summaries of clinical studies and issues related to implantable pump therapy are highlighted...
September 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27897039/use-of-nanotechnology-for-improved-pharmacokinetics-and-activity-of-immunogenic-cell-death-inducers-used-in-cancer-chemotherapy
#20
Martyna Janicka, Jerzy Gubernator
Immunogenic cell death inducers (ICD inducers) are a diverse group of therapeutic molecules capable of eliciting an adaptive immune response against the antigens present on the surface of dying cancer cells. Most of these molecules suffer from low bioavailability, high toxicity and poor pharmacokinetics which limit their application. It is believed that nanotechnology, in particular nano-sized nanocarriers, can address most of the issues that limit the use of ICD inducers. Area covered: The mechanism of action of ICD inducers and their limitations is discussed...
September 2017: Expert Opinion on Drug Delivery
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