journal
https://read.qxmd.com/read/38507231/a-neoteric-annotation-on-the-advances-in-combination-therapy-for-parkinson-s-disease-nanocarrier-based-combination-approach-and-future-anticipation-part-ii-nanocarrier-design-and-development-in-focus
#1
REVIEW
Devika Unnithan, Ali Sartaj, Mohammad Kashif Iqubal, Javed Ali, Sanjula Baboota
INTRODUCTION: The current treatment modalities available for Parkinson's disease (PD) prove inadequate due to the inherent constraints in effectively transporting bioactive compounds across the blood-brain barrier. The utilization of synergistic combinations of multiple drugs in conjunction with advanced nanotechnology, emerges as a promising avenue for the treatment of PD, offering potential breakthroughs in treatment efficacy, targeted therapy, and personalized medicine. AREAS COVERED: This review provides a comprehensive analysis of the efficacy of multifactorial interventions for PD, simultaneously addressing the primary challenges of conventional therapies and highlighting how advanced technologies can help overcome these limitations...
March 20, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38486470/ferulic-acid-s-therapeutic-odyssey-nano-formulations-pre-clinical-investigations-and-patent-perspective
#2
REVIEW
Sanshita, Monika, Snigdha Chakraborty, Oluwatoyin Adepeju Odeku, Inderbir Singh
No abstract text is available yet for this article.
March 15, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38481172/a-neoteric-annotation-on-the-advances-in-combination-therapy-for-parkinson-s-disease-nanocarrier-based-combination-approach-and-future-anticipation-part-i-exploring-theoretical-insights-and-pharmacological-advances
#3
REVIEW
Devika Unnithan, Ali Sartaj, Mohammad Kashif Iqubal, Javed Ali, Sanjula Baboota
INTRODUCTION: Parkinson's disease is a neurological condition defined by a substantial reduction in dopamine-containing cells in the substantia nigra. Levodopa (L-Dopa) is considered the gold standard in treatment. Recent research has clearly shown that resistance to existing therapies can develop. Moreover, the involvement of multiple pathways in the nigrostriatal dopaminergic neuronal loss suggests that modifying the treatment strategy could effectively reduce this degeneration. AREAS COVERED: This review summarizes the key concerns with treating PD patients and the combinations, aimed at effectively managing PD...
March 14, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38467560/recent-advances-in-the-application-of-clay-containing-hydrogels-for-hemostasis-and-wound-healing
#4
REVIEW
Xiaojuan Huang, Bin Hu, Xinyuan Zhang, Peng Fan, Zheng Chen, Shige Wang
INTRODUCTION: Immediate control of bleeding and anti-infection play important roles in wound management. Multiple organ dysfunction syndrome and death may occur if persistent bleeding, hemodynamic instability, and hypoxemia are not addressed. The combination of clay and hydrogel provides a new outlet for wound hemostasis. In this review, the current research progress of hydrogel/clay composite hemostatic agents was reviewed. AREAS COVERED: This paper summarizes the characteristics of several kinds of clay including kaolinite, montmorillonite, laponite, sepiolite, and palygorskite...
March 14, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38406829/mdsc-targeted-liposomal-all-trans-retinoic-acid-suppresses-mmdscs-and-improves-immunotherapy-in-hbv-infection
#5
JOURNAL ARTICLE
Samuel Kesse, Yuhong Xu, Sanyuan Shi, Shanshan Jin, Shafi Ullah, Yongchao Dai, Miao He, Anjie Zheng, Fengwei Xu, Zixiu Du, Raphael N Alolga, Jinliang Peng
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are evolving as a prominent determinant in cancer occurrence and development and are functionally found to suppress T cells in cancer. Not much research is done regarding its involvement in viral infections. This research was designed to investigate the role of MDSCs in hepatitis B virus (HBV) infection and how targeting these cells with our novel all-trans retinoic acid encapsulated liposomal formulation could improve immunotherapy in C57BL/6 mice...
February 26, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38396366/programmable-intratumoral-drug-delivery-to-breast-cancer-using-wireless-bioelectronic-device-with-electrochemical-actuation
#6
JOURNAL ARTICLE
Mohammad Souri, Sohail Elahi, Madjid Soltani
OBJECTIVE: Breast cancer is a global health concern that demands attention. In our contribution to addressing this disease, our study focuses on investigating a wireless micro-device for intratumoral drug delivery, utilizing electrochemical actuation. Microdevices have emerged as a promising approach in this field due to their ability to enable controlled injections in various applications. METHODS: Our study is conducted within a computational framework, employing models that simulate the behavior of the microdevice and drug discharge based on the principles of the ideal gas law...
February 23, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38396342/nanomicellar-eye-drops-a-review-of-recent-advances
#7
REVIEW
Valentina Paganini, Patrizia Chetoni, Mariacristina Di Gangi, Daniela Monti, Silvia Tampucci, Susi Burgalassi
INTRODUCTION: Research on nanotechnology in medicine has also involved the ocular field and nanomicelles are among the applications developed. This approach is used to increase both the water solubility of hydrophobic drugs and their penetration/permeation within/through the ocular tissues since nanomicelles are able to encapsulate insoluble drug into their core and their small size allows them to penetrate and/or diffuse through the aqueous pores of ocular tissues. AREAS COVERED: The present review reports the most significant and recent literature on the use of nanomicelles, made up of both surfactants and amphiphilic polymers, to overcome limitations imposed by the physiology of the eye in achieving a high bioavailability of drugs intended for the therapeutic areas of greatest commercial interest: dry eye, inflammation, and glaucoma...
February 23, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38349540/nanocarriers-in-topical-photodynamic-therapy
#8
REVIEW
Nina Dragicevic, Jelena Predic-Atkinson, Bojan Nikolic, Snezana B Pajovic, Sanja Ivkovic, Miroslav Adzic
INTRODUCTION: Photodynamic therapy (PDT) has gained significant attention due to its superiority over conventional treatments. In the context of skin cancers and nonmalignant skin diseases, topical application of photosensitizer formulations onto affected skin, followed by illumination, offers distinct advantages. Topical PDT simplifies therapy by providing easy access to the skin, increasing drug concentration within the target area, and confining residual photosensitivity to the treated skin...
February 20, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38344809/nanotechnology-mediated-delivery-of-resveratrol-as-promising-strategy-to-improve-therapeutic-efficacy-in-triple-negative-breast-cancer-tnbc-progress-and-promises
#9
REVIEW
Javed Ahmad, Javed Ahamad, Mohammed S Algahtani, Anuj Garg, Naiyer Shahzad, Mohammad Zaki Ahmad, Syed Sarim Imam
INTRODUCTION: Triple-negative breast cancer (TNBC) presents unique challenges indiagnosis and treatment.Resveratrolexhibits potential as a therapeutic intervention for TNBC byregulating various pathways such as the PI3K/AKT, RAS/RAF/ERK, PKCδ,and AMPK, leading to apoptosis through ROS-mediated CHOP activationand the expression of DR4 and DR5. However, the clinical efficacy of resveratrol is limited due to itspoor biopharmaceutical characteristics and low bioavailability at thetumor site...
February 12, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38344771/an-update-on-strategies-for-optimizing-polymer-lipid-hybrid-nanoparticle-mediated-drug-delivery-exploiting-transformability-and-bioactivity-of-pln-and-harnessing-intracellular-lipid-transport-mechanism
#10
REVIEW
Taksim Ahmed, Fuh-Ching Franky Liu, Xiao Yu Wu
INTRODUCTION: Polymer-lipid hybrid nanoparticle (PLN) is an emerging nanoplatform with distinct properties and functionalities from other nanocarrier systems. PLN can be optimized to overcome various levels of drug delivery barriers to achieve desired therapeutic outcomes via rational selection of polymer and lipid combinations based on a thorough understanding of their properties and interactions with therapeutic agents and biological systems. AREAS COVERED: This review provides an overview of PLN including the motive and history of PLN development, types of PLN, preparation methods, attestations of their versatility, and design strategies to circumvent various barriers for increasing drug delivery accuracy and efficiency...
February 12, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38340063/do-the-chitosan-nanoparticles-really-augment-the-drugs-transdermal-fluxes-ending-the-debate-using-meta-analysis
#11
REVIEW
Rania M Hathout, Rania A Ishak, Doaa H Shakshak
INTRODUCTION: Transdermal delivery has been extensively investigated as a successful alternative to the oral and parenteral routes of administration. The use of polymeric nanoparticles as drug delivery systems through this route has always been controversial. The use of meta-analyses is a useful quantitative means to decide upon the efficiency of this type of vehicles transporting drugs through the skin. AREAS COVERED: In this meta-analysis study, polymeric nanoparticles were quantitatively compared to conventional formulations in order to investigate the feasibility of using these particles in transdermal delivery...
February 10, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38299472/dose-accuracy-of-the-follitropin-alfa-pen-injector-2-0-the-follitropin-alfa-lutropin-alfa-2-1-combination-pen-injector-2-0-and-the-choriogonadotropin-alfa-pen-injector-1-0-used-for-fertility-treatment
#12
JOURNAL ARTICLE
Evelyn Cottell, Damien Michalet, Monica Lispi, Thiago Dantas Araujo, Ralf Gleixner, Salvatore Longobardi, Thomas D'Hooghe
BACKGROUND: This study aimed to confirm that the incremental dose/clicks system dispenses accurate doses for the Merck family of fertility pen injectors. RESEARCH DESIGN AND METHODS: Set doses (Vset ) for three dose dial settings (minimum dose [Vmin ], midpoint dose [Vmid ] and maximum dose [Vmax ] for the follitropin alfa, choriogonadotropin alfa [D2 classification: single use/variable dose], and follitropin alfa:lutropin-alfa 2:1 combination pen injectors) or a single Vset for the choriogonadotropin alfa (D1 classification: single use/single dose) were assessed...
February 1, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38284386/dual-loaded-liposomal-carriers-to-combat-chemotherapeutic-resistance-in-breast-cancer
#13
REVIEW
Mohamed El-Tanani, Hamdi Nsairat, Alaa A Aljabali, Ismail I Matalka, Alaaldin M Alkilany, Murtaza M Tambuwala
INTRODUCTION: The resistance to chemotherapy is a significant hurdle in breast cancer treatment, prompting the exploration of innovative strategies. This review discusses the potential of dual-loaded liposomal carriers to combat chemoresistance and improve outcomes for breast cancer patients. AREAS COVERED: This review discusses breast cancer chemotherapy resistance and dual-loaded liposomal carriers. Drug efflux pumps, DNA repair pathways, and signaling alterations are discussed as chemoresistance mechanisms...
January 29, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38271023/recent-advances-in-nanocrystal-based-technologies-applied-for-ocular-drug-delivery
#14
REVIEW
Feiyang Geng, Xingyan Fan, Yu Liu, Weiyue Lu, Gang Wei
INTRODUCTION: The intricate physiological barriers of the eye and the limited volume of eye drops impede efficient delivery of poorly water-soluble drugs. In the last decade, nanocrystals have emerged as versatile drug delivery systems in various administration routes from bench to bedside. The unique superiorities of nanocrystals, mainly embodied in high drug-loading capacity, good mucosal adhesion and penetration, and greatly improved drug solubility, reveal a promising prospect for ocular delivery of poorly water-soluble drugs...
January 25, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38258509/engineered-exosomes-derived-from-stem-cells-a-new-brain-targeted-strategy
#15
REVIEW
Waqas Ahmed, Songze Huang, Lukui Chen
INTRODUCTION: Using engineered exosomes produced from stem cells is an experimental therapeutic approach for treating brain diseases. According to reports, preclinical research has demonstrated notable neurogenesis and angiogenesis effects using modified stem cell-derived exosomes. These biological nanoparticles have a variety of anti-apoptotic, anti-inflammatory, and antioxidant properties that make them very promising for treating nervous system disorders. AREAS COVERED: This review examines different ways to enhance the delivery of modified stem cell-derived exosomes, how they infiltrate the blood-brain barrier (BBB), and how they facilitate their access to the brain...
January 23, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38248870/lipidated-brush-peg-polymers-as-low-molecular-weight-pulmonary-drug-delivery-platforms
#16
JOURNAL ARTICLE
Lisa M Kaminskas, Neville J Butcher, Christopher N Subasic, Ashok Kothapalli, Shadabul Haque, James L Grace, Alexander Morsdorf, Joanne T Blanchfield, Andrew K Whittaker, John F Quinn, Michael R Whittaker
OBJECTIVES: Nanomedicines are being actively developed as inhalable drug delivery systems. However, there is a distinct utility in developing smaller polymeric systems that can bind albumin in the lungs. We therefore examined the pulmonary pharmacokinetic behavior of a series of lipidated brush-PEG (5 kDa) polymers conjugated to 1C2 , 1C12 lipid or 2C12 lipids. METHODS: The pulmonary pharmacokinetics, patterns of lung clearance and safety of polymers were examined in rats...
January 22, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38243810/conjugates-of-amphotericin-b-to-resolve-challenges-associated-with-its-delivery
#17
REVIEW
Vineet Kumar Jain, Keerti Jain, Harvinder Popli
INTRODUCTION: Amphotericin B (AmB), a promising antifungal and antileishmanial drug, acts on the membrane of microorganisms. The clinical use of AmB is limited due to issues associated with its delivery including poor solubility and bioavailability, instability in acidic media, poor intestinal permeability, dose and aggregation state dependent toxicity, parenteral administration, and requirement of cold chain for transport and storage etc. AREAS COVERED: Scientists have formulated and explored various covalent conjugates of AmB to reduce its toxicity with increase in solubility, oral bioavailability, and payload or loading of AmB by using various polymers, lipids, carbon based nanocarriers, metallic nanoparticles, and vesicular carriers etc...
January 20, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38236621/3d-printing-in-vaginal-drug-delivery-a-revolution-in-pharmaceutical-manufacturing
#18
REVIEW
Sagar Narala, Ahmed Adel Ali Youssef, Siva Ram Munnangi, Nagarjuna Narala, Preethi Lakkala, Sateesh Kumar Vemula, Michael Repka
INTRODUCTION: The Food and Drug Administration's approval of the first three-dimensional (3D) printed tablet, Spritam®, led to a burgeoning interest in using 3D printing to fabricate numerous drug delivery systems for different routes of administration. The high degree of manufacturing flexibility achieved through 3D printing facilitates the preparation of dosage forms with many actives with complex and tailored release profiles that can address individual patient needs. AREAS COVERED: This comprehensive review provides an in-depth look into the several 3D printing technologies currently utilized in pharmaceutical research...
January 18, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38226932/a-review-on-the-use-of-extracellular-vesicles-for-the-delivery-of-drugs-and-biological-therapeutics
#19
REVIEW
Sundus Jabeen Amina, Tasmia Azam, Fatima Dagher, Bin Guo
INTRODUCTION: Exosomes, a type of extracellular vesicles, are effective tools for delivering small-molecule drugs and biological therapeutics into cells and tissues. Surface modifications with targeting ligands ensure precise delivery to specific cells, minimizing accumulation in healthy organs and reducing the side effects. This is a rapidly growing area in drug delivery research and this review aims to comprehensively discuss the recent advances in the field. AREA COVERED: Recent studies have presented compelling evidence supporting the application of exosomes as efficient delivery vehicles that escape endosome trapping, achieving effective in vivo delivery in animal models...
January 16, 2024: Expert Opinion on Drug Delivery
https://read.qxmd.com/read/38224039/intramuscular-injection-of-palmitic-acid-conjugated-exendin-4-loaded-multivesicular-liposomes-for-long-acting-and-improving-in-situ-stability
#20
JOURNAL ARTICLE
Huixian Tian, Minsi Chang, Yanlin Lyu, Nan Dong, Nini Yu, Tian Yin, Yu Zhang, Haibing He, Jingxin Gou, Xing Tang
BACKGROUND: Exendin-4 (Ex4) is a promising drug for diabetes mellitus with a half-life of 2.4 h in human bodies. Besides, the E×4formulations currently employed in the clinic or under development have problems pertaining to stability. In this study, palmitic acid-modified E×4(Pal-Ex4) was prepared and purified to extend the half-life of Ex4. In addition, Pal-Ex4-MVLs were further designed and optimized as a long-acting delivery system for intramuscular injection. METHODS: Pal-Ex4 was encapsulated within multivesicular liposomes (MVLs) via a two-step double emulsification process...
January 15, 2024: Expert Opinion on Drug Delivery
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