journal
MENU ▼
Read by QxMD icon Read
search

Expert Opinion on Drug Delivery

journal
https://www.readbyqxmd.com/read/28423954/the-design-and-scale-up-of-spray-dried-particle-delivery-systems
#1
Ali Al-Khattawi, Andrew Bayly, Andy Phillips, David Wilson
The rising demand for pharmaceutical particles with tailored physico-chemical properties has opened new markets for the spray drying technology especially for solubility enhancement, improvement of inhalation medicines and stabilization of biopharmaceuticals. Despite this, the literature on spray drying is scattered and often does not address the fundamental principles underpinning the robust development of pharmaceutical products. It is therefore necessary to present a clearer picture of the field and highlight the principles and factors influencing particle design and scale-up...
April 19, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28398108/porous-silicon-for-drug-delivery-applications-and-theranostics-recent-advances-critical-review-and-perspectives
#2
Tushar Kumeria, Steven J P McInnes, Shaheer Maher, Abel Santos
Porous silicon (pSi) engineered by electrochemical etching has been used as a drug delivery vehicle to address the intrinsic limitations of traditional therapeutics. Biodegradability, biocompatibility and optoelectronic properties make pSi a unique candidate for developing biomaterials for theranostics and photodynamic therapies. This review presents an updated overview about the recent therapeutic systems based on pSi, with a critical analysis on the problems and opportunities that this technology faces as well as highlighting pSi's growing potential...
April 11, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28394190/technology-derived-storage-solutions-for-stabilizing-insulin-in-extreme-weather-conditions-i-the-vivicap-1-device
#3
Andreas Pfützner, Gidi Pesach, Ron Nagar
BACKGROUND: Injectable life-saving drugs should not be exposed to temperatures <4°C/39°F or >30°C/86°F. Frequently, weather conditions exceed these temperature thresholds in many countries. Insulin is to be kept at 4-8°C/~ 39-47°F until use and once opened, is supposed to be stable for up to 31 days at room temperature (exception: 42 days for insulin levemir). Extremely hot or cold external temperature can lead to insulin degradation in a very short time with loss of its glucose-lowering efficacy...
April 10, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28359171/a-novel-pen-based-bluetooth-enabled-insulin-delivery-system-with-insulin-dose-tracking-and-advice
#4
Timothy S Bailey, Jenine Y Stone
Diabetes is growing in prevalence internationally. As more individuals require insulin as part of their treatment, technology evolves to optimize delivery, improve adherence, and reduce dosing errors. Insulin pens outperform vial and syringe in simplicity, dosing accuracy, and user preference. Bolus advisors improve dosing confidence and treatment adherence. The InPen System offers a novel approach to treatment via a wireless pen that syncs to a mobile application featuring a bolus advisor, enabling convenient insulin dose tracking and more accurate bolus advice among other features...
April 10, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28388851/dna-rna-based-formulations-for-treatment-of-breast-cancer
#5
Zhaolu Xie, Xianghui Zeng
To develop a successful formulation for the gene therapy of breast cancer, an effective therapeutic nucleic acid and proper delivery system are essential. Increased understanding of breast cancer, and developments in biotechnology, material science and nanotechnology have provided a major impetus in the development of effective formulations for the gene therapy of breast cancer. Areas covered: We discuss DNA/RNA-based formulations that can inhibit the growth of breast cancer cells and control the progress of breast cancer...
April 7, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28388248/the-effects-of-particle-size-shape-density-and-flow-characteristics-on-particle-margination-to-vascular-walls-in-cardiovascular-diseases
#6
Hang T Ta, Nghia P Truong, Andrew K Whittaker, Thomas P Davis, Karlheinz Peter
Vascular-targeted drug delivery is a promising approach for the treatment of atherosclerosis, due to the vast involvement of endothelium in the initiation and growth of plaque, a characteristic of atherosclerosis. One of the major challenges in carrier design for targeting cardiovascular diseases (CVD) is that carriers must be able to navigate the circulation system and efficiently marginate to the endothelium in order to interact with the target receptors. Areas covered: This review draws on studies that have focused on the role of particle size, shape, and density (along with flow hemodynamics and hemorheology) on the localization of the particles to activated endothelial cell surfaces and vascular walls under different flow conditions, especially those relevant to atherosclerosis...
April 7, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28379040/drug-delivery-of-oral-anti-cancer-fluoropyrimidine-agents
#7
Koh Miura, Hiroshi Shima, Naoko Takebe, Julie Rhie, Kennichi Satoh, Yoichiro Kakugawa, Masayuki Satoh, Makoto Kinouchi, Kuniharu Yamamoto, Yasuhiro Hasegawa, Masaaki Kawai, Kousuke Kanazawa, Tsuneaki Fujiya, Michiaki Unno, Ryuichi Katakura
Sixty years since its introduction, 5-FU still forms the core of chemotherapy regimens for many types of malignancies. 5-FU is a time-dependent drug but is rapidly degraded in plasma by dihydropyrimidine dehydrogenase (DPD). Although originally developed in an intravenous form, 5-FU oral prodrugs were developed with the goal of improving efficacy and minimizing toxicity as well as to capitalize on the advantages of oral drug administration. The inactive 5-FU prodrug is gradually converted into the active form in the systemic circulation...
April 5, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28291372/spotlight-on-the-delivery-of-photosensitizers-different-approaches-for-photodynamic-based-therapies
#8
Diogo Silva Pellosi, Priscila da Costa Carvalho De Jesus, Antonio Claudio Tedesco
Nanomedicine development allowed the discovery of new photosensitizers (PS) and drug delivery systems (DDS) to overcome current issues on phototherapy. Nano-engineered materials have the potential to improve the solubility of PS, control drug pharmacokinetics, decreasing side effects, increasing bioavailability, and overcoming multidrug resistance. A recent approach is the co-delivery of PS with other therapeutic agents in a multimodal platform for synergic and improved results. Areas covered: This paper discusses the delivery of PS-nanostructured platforms for conventional, photothermal, and antimicrobial photodynamic therapies, as well as in a recent therapeutic modality for photobiomodulation, covering applications of cancer diagnosis, targeting to skin pathogens, photoregeneration and wound healing...
March 27, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28338352/formulation-challenges-for-21st-century-topical-and-transdermal-delivery-systems
#9
Mayank Singhal, Maria Lapteva, Yogeshvar N Kalia
No abstract text is available yet for this article.
March 24, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28290714/polymeric-micelles-for-targeted-tumor-therapy-of-platinum-anticancer-drugs
#10
Yuki Mochida, Horacio Cabral, Kazunori Kataoka
Platinum anticancer drugs are effective against a wide range of tumors, though their severe adverse effects and resistance remain unresolved. A breakthrough in these drawbacks could be achieved by using polymeric micelles, i.e. nanoassemblies having a drug loaded core and a protective hydrophilic shell, incorporating platinum drugs for tumor-targeted delivery. Areas covered: The development of cisplatin- (NC-6004) and DACHPt-loaded micelles (NC-4016) has been reviewed, particularly, from the viewpoint of the effect of their structural features on the tumor-targeting efficacy...
March 14, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28286978/seeking-better-topical-delivery-technologies-of-moisturizing-agents-for-enhanced-skin-moisturization
#11
Hyeongmin Kim, Jeong Tae Kim, Sonia Barua, Seung-Yup Yoo, Seong-Chul Hong, Kyung Bin Lee, Jaehwi Lee
An adequate hydration level is essential to maintain epidermal barrier functions and normal physiological activities of skin tissues. Diverse moisturizing agents and pharmaceutical formulations for dermal deliveries have thus extensively been investigated. This review comprehensively discusses scientific outcomes of moisturizing agents and pharmaceutical vehicles for skin moisturization, thereby providing insight into designing innovative pharmaceutical formulations for effective skin moisturization. Areas covered: We discussed the functions of various moisturizing agents ranging from conventional creams to novel moisturizers which has recently been explored...
March 13, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28276966/in-situ-forming-biodegradable-poly-%C3%AE%C2%B5-caprolactone-microsphere-systems-a-challenge-for-transarterial-embolization-therapy-in-vitro-and-preliminary-ex-vivo-studies
#12
Andrea Salis, Elena P Porcu, Elisabetta Gavini, Giulia R Fois, Antonia Icaro Cornaglia, Giovanna Rassu, Marco Diana, Marcello Maestri, Paolo Giunchedi, Ioannis Nikolakakis
BACKGROUND: In situ forming biodegradable poly(ε-caprolactone) (PCL) microspheres (PCL-ISM) system was developed as a novel embolic agent for transarterial embolization (TAE) therapy of hepatocellular carcinoma (HCC). Ibuprofen sodium (Ibu-Na) was loaded on this platform to evaluate its potential for the treatment of post embolization syndrome. METHODS: The influence of formulation parameters on the size/shape, encapsulation efficiency and drug release was investigated using mixture experimental design...
March 1, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28276967/near-infrared-biophotonics-based-nanodrug-release-systems-and-their-potential-application-for-neuro-disorders
#13
Vidya Sagar, Madhavan Nair
Near-infrared ray (NIR)-responsive 'smart' nanoagents allow spatial and temporal control over the drug delivery process, noninvasively, without affecting healthy tissues and therefore they possess high potential for on-demand, targeted drug/gene delivery. Various NIR-responsive drug/gene delivery techniques are under investigation for peripheral disorders (especially for cancer). Nonetheless, their potential not been extensively examined for brain biomedical application. Areas covered: This review focuses on NIR-responsive characteristics of different NIR-nanobiophotonics-based nanoagents and associated drug delivery strategies...
February 28, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28276968/delivery-of-drugs-growth-factors-genes-and-stem-cells-via-intrapericardial-epicardial-and-intramyocardial-routes-for-sustained-local-targeted-therapy-of-myocardial-disease
#14
Mikhail Maslov, Stephan Foianini, Mark Lovich
Local myocardial delivery (LMD) of therapeutic agents is a promising strategy that aims to treat various myocardial pathologies. It is designed to deliver agents directly to the myocardium and minimize their extracardiac concentrations and side effects. LMD aims to enhance outcomes of existing therapies by broadening their therapeutic window and to utilize new agents that could not be otherwise be implemented systemically. Areas covered: This article provides a historical overview of six decades LMD evolution in terms of the approaches, including intrapericardial, epicardial, and intramyocardial delivery, and the wide array of classes of agents used to treat myocardial pathologies...
February 22, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28276969/the-influence-of-excipients-on-physical-and-pharmaceutical-properties-of-oral-lyophilisates-containing-a-pregabalin-acetaminophen-combination
#15
Aurica P Chiriac, Alina Diaconu, Loredana E Nita, Nita Tudorachi, Liliana Mititelu-Tartau, Andreea Creteanu, Oana Dragostin, Daniela Rusu, Gratiela Popa
OBJECTIVES: The purpose of the study was to investigate and characterize the oral lyophilisates containing the pregabalin-acetaminophen drug combination and as xcipients mannitol with microcrystalline cellulose or hydroxypropyl methylcellulose, in order to conclude upon drug-excipient interactions and their stability implications, impact of excipients on drug release and on the physicochemical and mechanical properties of the pharmaceutical formulations. METHODS: The oral tablets were made by using a Christ freeze-dryer alpha 2-4-LSC lyophilizer, and evaluated for stability, drug-excipient compatibility and homogeneity of the prepared pharmaceutical formulations...
February 20, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28266887/strategies-to-optimize-sirna-delivery-to-hepatocellular-carcinoma-cells
#16
Lucia Scarabel, Francesca Perrone, Marica Garziera, Rossella Farra, Mario Grassi, Francesco Musiani, Concetta Russo Spena, Barbara Salis, Lucia De Stefano, Giuseppe Toffoli, Flavio Rizzolio, Federica Tonon, Michela Abrami, Gianluca Chiarappa, Gabriele Pozzato, Giancarlo Forte, Gabriele Grassi, Barbara Dapas
hepatocellular carcinoma (hcc) is the predominant form of primary liver cancer and the second leading cause of cancer-associated mortality worldwide. available therapies for hcc have limited efficacy due to often late diagnosis and the general resistance of hcc to anti-cancer agents; therefore, the development of novel therapeutics is urgently required. small-interfering rna (sirna) molecules are short, double-stranded rnas that specifically recognize and bind the mrna of a target gene to inhibit gene expression...
February 17, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28140682/patient-evaluation-of-the-redesigned-follitropin-alfa-pen-injector
#17
Joan Schertz, Hilary Worton
OBJECTIVES: We aimed to evaluate the overall impressions of learning and subsequent use of the redesigned GONAL-f® (follitropin alfa) pen injector by women with recent or current infertility requiring assisted reproductive technologies (ART) or in vitro fertilization (IVF). METHODS: This was a simulated-use study including 86 women with infertility and 30 fertility nurses. Nurses trained the women on the use of the redesigned pen. The opinions of the women on the pen injector were collected during a questionnaire interview...
February 15, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28151692/oral-liquid-levothyroxine-solves-the-problem-of-tablet-levothyroxine-malabsorption-due-to-concomitant-intake-of-multiple-drugs
#18
Roberto Vita, Flavia Di Bari, Salvatore Benvenga
BACKGROUND: Unlike the tablet (TAB) formulation, liquid L-T4 (LIQ) is directly absorbed in the intestine. The aim of this study was to assess whether LIQ was superior to TAB, such that it would overcome the interference induced by co-ingestion of multiple interfering drugs (ID). METHODS: In this prospective cohort study, we recruited 11 patients with apparent reduced TAB absorption due to ≥ 2 ID, and switched them to LIQ while maintaining the daily dose and the co-ingestion of the ID...
February 13, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28165836/future-prospects-for-gene-delivery-systems
#19
Lale Kuşcu, Ali Demir Sezer
Gene therapy is the challenging area of biotechnology. Despite its promise for critical diseases, it has serious safety and efficiency issues, particularly with regards to gene transfer systems. Areas covered: We examined the current situation with gene transfer systems and addressed problems this technology. We then searched patent applications about in the area from the Patentscope online system, the international patent database. We analyzed the data obtained to get a general idea about gene delivery systems designed for future use and assessed approaches for more efficient, safer and valid delivery systems...
February 6, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28128004/long-acting-slow-effective-release-antiretroviral-therapy
#20
Benson Edagwa, JoEllyn McMillan, Brady Sillman, Howard E Gendelman
Advances in long-acting antiretroviral therapy (ART) can revolutionize current HIV/AIDS treatments. We coined the term 'long-acting slow effective release ART' (LASER ART) to highlight the required formulation properties of slow drug dissolution, poor water-solubility, bioavailability, little-to-no off-target toxicities and improved regimen adherence. Drug carrier technologies characterized by high antiretroviral drug (ARV) payloads in a single carrier improve the pharmacokinetic and pharmacodynamic profiles...
February 6, 2017: Expert Opinion on Drug Delivery
journal
journal
40792
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"