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German Medical Science: GMS E-journal

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https://www.readbyqxmd.com/read/28243189/prevalence-of-depression-anxiety-adjustment-disorders-and-somatoform-disorders-in-patients-with-age-related-macular-degeneration-in-germany
#1
Louis Jacob, Alexandra Spiess, Karel Kostev
Aims: The purpose of this study was to analyze the prevalence of depression, anxiety, adjustment disorders, and somatoform disorders in patients diagnosed with age-related macular degeneration (AMD) in Germany. Methods: This study included 7,580 patients between the ages of 40 and 90 diagnosed with AMD between January 2011 and December 2014 in 1,072 primary care practices (index date). The last follow-up was in July 2016. We also included 7,580 controls without AMD, which were matched (1:1) to the AMD cases by age, sex, type of health insurance (private or statutory), physician, and Charlson comorbidity score as a generic marker of comorbidity...
2017: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/28243188/myeloid-sarcoma-a-report-of-four-cases-at-unusual-sites
#2
Fouzia Siraj, Manveen Kaur, Varsha Dalal, Ashima Khanna, Afaq Ahmad Khan
Background: Myeloid sarcoma (MS) or granulocytic sarcoma is a rare tumor consisting of myeloid blasts with or without maturation occurring at anatomic sites other than the bone marrow. MS can involve any organ system but shows a predilection for skin, bone, and soft tissues of head and neck region. Case report: We report four cases of MS occurring at unusual sites, out of which three were de novo and one was associated with acute myeloid leukemia (AML). Conclusion: Although MS is associated with AML, it can rarely present without any existent hematologic disease...
2017: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/28163667/current-practice-and-perspectives-in-cro-oversight-based-on-a-survey-performed-among-members-of-the-german-association-of-research-based-pharmaceutical-companies-vfa
#3
Michael Hennig, Ferdinand Hundt, Susanne Busta, Stefan Mikus, Per-Holger Sanden, Andrea Sörgel, Thorsten Ruppert
In recent years, the number and scope of outsourced activities in the pharmaceutical industry have increased heavily. In addition, also the type of outsourcing has changed significantly in that time. This raises the question of whether and how sponsors retain the capability to select and to control the contract research organizations (CROs) involved and what expertise still has to be present in the development department as well as other relevant departments to ensure adequate oversight, also in line with the expectations of regulators and health authorities...
2017: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/28149258/the-prevalence-of-chronic-pain-in-orchestra-musicians
#4
Elena R Gasenzer, Marie-Juliana Klumpp, Dawid Pieper, Edmund A M Neugebauer
Background: The study investigated the incidence of chronic pain as well as causes and mechanisms of pain chronification in orchestra musicians. Aims: Chronic pain is a serious problem in the study group due to very specific playing techniques and body positions while playing, with a high impact on professional and private life. Methods: 8,645 professional musicians from 132 German cultural orchestras were contacted and asked about chronic pain via an online questionnaire. The study group comprised orchestra musicians suffering from pain...
2017: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/28066159/tst36-stapling-for-rectocele-and-hemorrhoidal-prolapse-early-results-of-the-prospective-german-multicenter-study
#5
Sven Petersen, Daniel Sterzing, Andreas Ommer, Assen Mladenov, Zrino Nakic, Faramaz Pakravan, Katja Wolff, Eric P M Lorenz, Ruediger L Prosst, Marco Sailer, Roland Scherer
Introduction: The aim of the study was to evaluate the safety and feasibility of stapled transanal procedures performed by a 36 mm stapling device, the so-called TST36 stapler. Methods: From September 2013 to June 2014 a prospective observational study was carried out by 8 proctology centers in Germany. The Cleveland Clinic Incontinence Score (CCIS) for incontinence and the Altomare ODS score were determined preoperatively. Follow-up examinations were performed after 14 days, one month and 6 months, at this time both scores were reevaluated...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/27980520/quality-of-care-in-patients-with-atrial-fibrillation-in-primary-care-a-cross-sectional-study-comparing-clinical-and-claims-data
#6
Rebekka Preuss, Jean-François Chenot, Aniela Angelow
Objectives: Atrial fibrillation (AF) is a common cardiac arrhythmia with increased risk of thromboembolic stroke. Oral anticoagulation (OAC) reduces stroke risk by up to 68%. The aim of our study was to evaluate quality of care in patients with AF in a primary health care setting with a focus on physician guideline adherence for OAC prescription and heart rate- and rhythm management. In a second step we aimed to compare OAC rates based on primary care data with rates based on claims data. Methods: We included all GP practices in the region Vorpommern-Greifswald, Germany, which were willing to participate (N=29/182, response rate 16%)...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/27790079/refractory-myasthenia-gravis-clinical-profile-comorbidities-and-response-to-rituximab
#7
Sreenivasa Rao Sudulagunta, Mona Sepehrar, Mahesh Babu Sodalagunta, Aravinda Settikere Nataraju, Shiva Kumar Bangalore Raja, Deepak Sathyanarayana, Siddharth Gummadi, Hemanth Kumar Burra
Introduction: Myasthenia gravis (MG) is an antibody mediated autoimmune neuromuscular disorder characterized by fatigable muscle weakness. A proportion of myasthenia gravis patients are classified as refractory due to non responsiveness to conventional treatment. This retrospective study was done to evaluate clinical profile, epidemiological, laboratory, and features of patients with MG and mode of management using rituximab and complications. Methods: Data of myasthenia gravis patients admitted or presented to outpatient department (previous medical records) with MG between January 2008 and January 2016 were included...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/27703428/solitary-langerhans-cell-histiocytosis-of-the-hard-palate-a-diagnostic-pitfall
#8
Dalal Varsha, Manveen Kaur, Neena Chaudhary, Fouzia Siraj
Langerhans cell histiocytosis (LCH) is a relatively rare and unique disease characterized by an abnormal proliferation of immature dendritic cells. It is predominantly seen in children with adults showing less than ten times the incidence compared to childhood. The clinical presentation and organ involvement is highly variable. Oral manifestations generally consist of mucosal ulceration associated with lesions of the underlying bone. Lesions limited to the oral mucosa are rare. We present a case of a 45-year-old male who presented with an ulcer on the hard palate showing histopathologic features of LCH...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/27610052/the-sword-of-damocles-for-the-splenectomised-death-by-opsi
#9
Christian Georg Blumentrath, Nils Ewald, Jasmina Petridou, Uwe Werner, Barbara Hogan
The overwhelming post splenectomy infection (OPSI) in splenectomised patients is a rare but severe infection mostly caused by encapsulated bacteria. We analyse the case of a 65-year-old female patient who was presented with clinical and laboratory findings indicating gastroenteritis. Two years years before admission, the patient underwent a splenectomy for a two stage splenic rupture following resuscitation for pulmonary embolism. Immunisation of the patient was complete and timely. As a result of the unspecific clinical presentation, there was a delay in administration of antibiotics...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/27499726/evidence-mapping-for-decision-making-feasibility-versus-accuracy-when-to-abandon-high-sensitivity-in-electronic-searches
#10
Barbara Buchberger, Laura Krabbe, Beate Lux, Jessica Tajana Mattivi
BACKGROUND: Mapping the evidence is a relatively new methodological approach and may be helpful for the development of research questions and decisions about their relevance and priority. However, the amount of data available today leads to challenges for scientists sometimes being confronted with literature searches retrieving over 30,000 results for screening. OBJECTIVES: We conducted an evidence mapping of the topic "diabetes and driving" to investigate its suitability for an evidence-based national clinical guideline...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/27408610/heat-for-wounds-water-filtered-infrared-a-wira-for-wound-healing-a-review
#11
REVIEW
Gerd Hoffmann, Mark Hartel, James B Mercer
BACKGROUND: Water-filtered infrared-A (wIRA) is a special form of heat radiation with high tissue penetration and a low thermal load to the skin surface. wIRA corresponds to the major part of the sun's heat radiation, which reaches the surface of the Earth in moderate climatic zones filtered by water and water vapour of the atmosphere. wIRA promotes healing of acute and chronic wounds both by thermal and thermic as well as by non-thermal and non-thermic cellular effects. METHODS: This publication includes a literature review with search in PubMed/Medline for "water-filtered infrared-A" and "wound"/"ulcus" or "wassergefiltertes Infrarot A" and "Wunde"/"Ulkus", respectively (publications in English and German), and additional analysis of study data...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/27408609/sellar-reconstruction-without-intrasellar-packing-after-endoscopic-surgery-of-pituitary-macroadenomas-is-better-than-its-reputation
#12
Mostafa Ismail, Abd Alla Fares, Balegh Abdelhak, Jean D'Haens, Olaf Michel
OBJECTIVES: Sellar reconstruction with intrasellar packing following endoscopic resection of pituitary macroadenomas remains a subject of clinical and radiological discussion particularly, when an intraoperative cerebrospinal fluid (CSF) leakage is absent. This study was conducted to contribute our experience with sellar reconstruction after a standard endoscopic surgery of pituitary macroadenomas without intraoperative CSF leakage to the ongoing discussion between techniques with and without intrasellar packing...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/27346991/impact-of-caesarean-section-on-mode-of-delivery-pregnancy-induced-and-pregnancy-associated-disorders-and-complications-in-the-subsequent-pregnancy-in-germany
#13
Louis Jacob, Sevil Taskan, George Macharey, Ingeborg Sechet, Volker Ziller, Karel Kostev
OBJECTIVES: To analyze the impact of caesarean section (CS) on mode of delivery, pregnancy-induced and pregnancy-associated disorders, as well as complications in the subsequent pregnancy within German gynecological practices. METHODS: 1,801 women with CS and 1,801 matched women with vaginal delivery (VD) from the IMS Disease Analyzer database were included. The impact of previous CS on the mode of delivery and pregnancy-associated disorders as well as complications prior to or during birth in the subsequent pregnancy were analyzed...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/27158251/switching-to-instant-black-coffee-modulates-sodium-selenite-induced-cataract-in-rats
#14
COMPARATIVE STUDY
E A El Okda, M M Mohamed, E B Shaheed, A R Abdel-Moemin
The influence of daily consumption of some common beverages on the development of cataract in rats was investigated. Total phenol content was determined in the beverages and an oral standardized dose of total phenols from each beverage was given to the treated rats. Weaned male albino rats were used and divided into five groups (n=7). Rats were fed Ain 93G and administered the standardized dose of instant coffee, black tea and hibiscus beverages for 30 days. On day 14 all rats were injected with a single dose of sodium selenite (Na2SeO3) 15 µmol/kg bodyweight, except the control groups NC (negative control, did not receive Na2SeO3) and PC (positive control, was already injected on day 1 of the study)...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/27141211/effect-of-chaetocin-on-renal-cell-carcinoma-cells-and-cytokine-induced-killer-cells
#15
COMPARATIVE STUDY
Roman Rombo, Hans Weiher, Ingo G H Schmidt-Wolf
We examined the cytotoxic effects of chaetocin on clear cell renal cell carcinoma (ccRCC) cells and the possibility to combine the effects of chaetocin with the effects of cytokine-induced killer cells (CIK) assayed by MTT assay and FACS analysis. Chaetocin is a thiodioxopiperazine produced by fungi belonging to the chaetomiaceae family. In 2007, it was first reported that chaetocin shows potent and selective ex vivo anti-cancer activity by inducing reactive oxygen species. CIK cells are generated from CD3+/CD56- T lymphocytes with double negative CD4-/CD8- phenotype that are isolated from human blood...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/26977142/prevalence-of-chronic-diseases-among-older-patients-in-german-general-practices
#16
Louis Jacob, Jessica Breuer, Karel Kostev
AIMS: To evaluate the prevalence of chronic diseases (CDs) among older patients in German general practices (GPs). METHODS: A total of 840,319 patients older than 65 years (359,289 male and 481,030 female) who consulted a GP between January and December 2014 were selected. Ten different CDs were considered: hypertension, lipid metabolism, diabetes, coronary heart disease, cancer, chronic obstructive pulmonary disease, heart failure, stroke, chronic kidney disease and osteoporosis...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/26941590/gender-based-differences-in-the-antidepressant-treatment-of-patients-with-depression-in-german-psychiatric-practices
#17
Louis Jacob, Karel Kostev
BACKGROUND: Depression is recognized as the leading cause of disability in the world. Our goal was to compare treatment initiation in men and women treated in German neuropsychiatric practices after diagnosis of depression. METHODS: Patients aged between 18 and 80 first diagnosed with depression between 2010 and 2013 were identified by 223 psychiatrists in the IMS Disease Analyzer database. Patients who had received antidepressant prescriptions prior to the index date were excluded...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/26909012/recurrent-urinary-tract-infections-and-complications-after-symptomatic-versus-antibiotic-treatment-follow-up-of-a-randomised-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Jutta Bleidorn, Eva Hummers-Pradier, Guido Schmiemann, Birgitt Wiese, Ildikó Gágyor
BACKGROUND: Uncomplicated urinary tract infections (UTI) are common in general practice, and are usually treated with antibiotics. Recurrent UTI often pose a serious problem for affected women. Little is known about recurrent UTI and complications when uncomplicated UTI are treated without antibiotics. With ICUTI (Immediate vs. conditional antibiotic use in uncomplicated UTI, funded by BMBF No. 01KG1105) we assessed whether initial symptomatic treatment with ibuprofen could be a treatment alternative for uncomplicated UTI...
2016: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/26693218/quality-expectations-and-tolerance-limits-of-trial-master-files-tmf-developing-a-risk-based-approach-for-quality-assessments-of-tmfs
#19
Arthur Hecht, Barbara Busch-Heidger, Heiner Gertzen, Heike Pfister, Birgit Ruhfus, Per-Holger Sanden, Gabriele B Schmidt
This article addresses the question of when a trial master file (TMF) can be considered sufficiently accurate and complete: What attributes does the TMF need to have so that a clinical trial can be adequately reconstructed from documented data and procedures? Clinical trial sponsors face significant challenges in assembling the TMF, especially when dealing with large, international, multicenter studies; despite all newly introduced archiving techniques it is becoming more and more difficult to ensure that the TMF is complete...
2015: German Medical Science: GMS E-journal
https://www.readbyqxmd.com/read/26633965/autoimmune-thyroiditis-associated-with-neuromyelitis-optica-nmo
#20
Sreenivasa Rao Sudulagunta, Mahesh Babu Sodalagunta, Hadi Khorram, Mona Sepehrar, Jayadevappa Gonivada, Zahra Noroozpour, Nagendra Prasad
Neuromyelitis optica (NMO or Devic's syndrome) is a rare relapsing demyelinating disease of the central nervous system (CNS) that mainly affects the spinal cord and optic nerves and shares many clinical and radiological features with multiple sclerosis. The association of NMO with other autoimmune diseases was reported, but very few reports described association with autoimmune thyroid disease. Early differentiation between NMO and multiple sclerosis is very important as the natural course and treatment regimens differ significantly...
2015: German Medical Science: GMS E-journal
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