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Photodiagnosis and Photodynamic Therapy

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https://www.readbyqxmd.com/read/28300725/diagnosis-of-occlusal-caries-lesions-in-deciduous-molars-by-coherent-light-scattering-pattern-speckle
#1
Silvia Regina Garcia Olivan, Alessandro Melo Deana, Marcelo Mendes Pinto, Ravana Angelini Sfalcin, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Renato Araujo Prates, Sandra Kalil Bussadori
BACKGROUND: In this study is presented the correlation between laser speckle images and detection of incipient caries lesions by changing the microstructure of the surface of tooth enamel. METHODS: We used 30 healthy deciduous molar teeth collected from the Biobank Human Teeth, Faculty of Dentistry, University of São Paulo who had carious lesions induced by the pH cycling method. The samples were evaluated for the diagnosis of caries by two METHODS: ICDAS and speckle pattern of coherent light scattering after 5, 10 and 15days and the results were statistically analyzed using α=0...
March 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28300724/methylene-blue-curcumin-and-ion-pairing-nanoparticles-effects-on-photodynamic-therapy-of-mda-mb-231-breast-cancer-cell
#2
Reza Hosseinzadeh, Khatereh Khorsandi
PURPOSE: The aim of current study was to use methylene blue-curcumin ion pair nanoparticles and single dyes as photosensitizer for comparison of photodynamic therapy (PDT) efficacy on MDA-MB-231 cancer cells, also various light sources effect on activation of photosensitizer (PS) was considered. METHOD: Ion pair nanoparticles were synthesized using opposite charge ions precipitation and lyophilized. The PDT experiments were designed and the effect of PSs and light sources (Red LED (630nm; power density: 30mWcm(-2)) and blue LED (465nm; power density: 34mWcm(-2))) on the human breast cancer cell line were examined...
March 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28300723/nuclear-medicine-for-photodynamic-therapy-in-cancer-planning-monitoring-and-nuclear-pdt
#3
REVIEW
Dris Kharroubi Lakouas, Damien Huglo, Serge Mordon, Maximilien Vermandel
Photodynamic therapy (PDT) is a modality with promising results for the treatment of various cancers. PDT is increasingly included in the standard of care for different pathologies. This therapy relies on the effects of light delivered to photosensitized cells. At different stages of delivery, PDT requires imaging to plan, evaluate and monitor treatment. The contribution of molecular imaging in this context is important and continues to increase. In this article, we review the contribution of nuclear medicine imaging in oncology to PDT for planning and therapeutic monitoring purposes...
March 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28300722/effect-of-5-aminolevulinic-acid-photodynamic-therapy-on-keratinocyte-proliferation-and-apoptosis-in-condyloma-acuminatum
#4
Guangwen Yin, Ke Sha, Bingjie Cai, Fangfang Li, Xuyang Li, Xianxian Xia, Xinxin Pan
BACKGROUND: The effect of 5-aminolevulinic acid photodynamic therapy on keratinocyte proliferation and apoptosis in condyloma acuminatum tissues was evaluated. METHODS: An immunohistochemical method and TdT-mediated dUTP nick end labeling were performed to detect the positive expression of the keratinocyte proliferation-related gene Ki-67 and apoptosis, respectively, in condyloma acuminatum tissues. RESULTS: Of 52 cases, 44 showed positive expression of Ki-67 in condyloma acuminatum keratinocytes before the treatment, with a positive expression rate of 84...
March 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28279796/tetrahydroporphyrin-tetratosylat-thpts-a-near-infrared-photosensitizer-for-targeted-and-efficient-photodynamic-therapy-pdt-of-human-bladder-carcinoma-an-in-vitro-study
#5
Mandy Berndt-Paetz, Annett Weimann, Nadine Sieger, Stanislaw Schastak, Yasser M Riyad, Jan Griebel, Vinodh K A Arthanareeswaran, Jens-Uwe Stolzenburg, Jochen Neuhaus
BACKGROUND: Efficacy of PDT in muscle-invasive bladder cancer is hampered by low tissue penetration of most photosensitizers by short excitation wavelength. THPTS is excitable at near-infrared (760nm) allowing tissue penetration up to 15mm. We examined the cellular effects of THPTS-PDT in human bladder cancer cells. MATERIAL AND METHODS: We used four human transitional carcinoma cell lines, epithelial bladder progenitors (HBLAK) and bladder smooth muscle cells (HBSMC)...
March 6, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28257944/a-quantitative-study-of-in-vivo-protoporphyrin-ix-fluorescence-build-up-during-occlusive-treatment-phases
#6
C Louise Campbell, C Tom A Brown, Kenneth Wood, Ana Gabriela Salvio, Natalia M Inada, Vanderlei S Bagnato, Harry Moseley
BACKGROUND: Topical photodynamic therapy (PDT) is a non-invasive light based therapy used to treat non-melanoma skin cancer (NMSC) and dysplasia. During PDT, the light sensitive molecule protoporphyrin IX (PpIX) is activated, resulting in the production of singlet oxygen, which subsequently leads to cell death. PpIX is metabolised from a topically applied pro-drug and the strong fluorescence signal associated with PpIX can be utilised as an indicator of the amount of PpIX present within the tumour tissue...
February 28, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28257943/photodynamic-therapy-enhances-the-efficacy-of-gene-directed-enzyme-prodrug-therapy
#7
Catherine Christie, Aftin Pomeroy, Rohit Nair, Kristian Berg, Henry Hirschberg
INTRODUCTION: Gene-directed enzyme prodrug therapy (GDEPT) employing the cytosine deaminase (CD) gene, which encodes an enzyme that converts the nontoxic agent 5-fluorocytosine (5-FC) into the chemotherapeutic drug 5-fluorouracil (5-FU), has shown promise both in experimental animals and in clinical trials. Nevertheless, with the transfection systems available presently the percentage of tumor cells incorporating the desired gene is usually too low for successful therapy. We have examined the ability of photodynamic therapy (PDT) to enhance the efficacy of the metabolites, converted from 5-FC by CD gene transfected rat glioma cells...
February 28, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28254552/assessment-of-in-vivo-experiments-the-newly-synthesized-porphyrin-with-proper-light-source-enhanced-effectiveness-of-pdt-comparing-to-5-ala
#8
Kamil Jurczyszyn, Marta Woźniak, Krzysztof Symonowicz, Natasza Sprutta, Lechosław Latos-Grażyński, Piotr Ziółkowski, Yurij Ivonyak, Piotr Tuchowski, Witold Trzeciakowski
BACKGROUND: The search for new photosensitizers for application in photodynamic therapy has quite a long history. In the past, a large number of potent photosensitizers were used in both basic and clinical studies; however, only a few turned out to be effective and safe. METHODS: In the present study, two compounds were used: 5-aminolevulinic acid in two formulations (free and liposomal), and the newly synthesized porphyrin, 5,10,15,20-tetra-p-tolyl-22,24-dithiadibenzocarbaporphyrin, termed DTDB...
February 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28254551/in-silico-identification-of-a-therapeutic-target-for-photo-activated-disinfection-with-indocyanine-green-modeling-and-virtual-screening-analysis-of-arg-gingipain-from-porphyromonas-gingivalis
#9
Maryam Pourhajibagher, Abbas Bahador
BACKGROUND: Porphyromonas gingivalis is a momentous bacterial etiological agent associated with periodontitis, peri-implantitis as well as endodontic infections. The potential advantage of Photo-activated disinfection (PAD) as a promising novel approach is the choice of a suitable target site, specific photosensitizer, and wavelength of light for delivery of the light from source to target. Since Arg-gingipain is a cysteine proteinase that is involved in the virulence of P. gingivalis, it was evaluated as a target site for PAD with indocyanine green (ICG) as a photosensitizer...
February 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28249746/the-evaluation-of-cultivable-microbiota-profile-in-patients-with-secondary-endodontic-infection-before-and-after-photo-activated-disinfection
#10
Maryam Pourhajibagher, Roghayeh Ghorbanzadeh, Steven Parker, Nasim Chiniforush, Abbas Bahador
BACKGROUND: Secondary/persistent endodontic infection can be the outcome of failure of endodontic treatment. Photo-activated disinfection (PAD) can be a useful adjunct to mechanical and antimicrobial agents in eliminating endopathogenic microorganisms. In this study, we evaluated the effect of PAD on diversity and count of microbiota related to secondary/persistent endodontic infections. MATERIALS AND METHODS: Root canal samples were taken using sterile paper points from the root canals of 14 patients with secondary/persistent endodontic infections after removing the root-canal filling materials...
February 26, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28242435/liposomal-delivery-of-ferrous-chlorophyllin-a-novel-third-generation-photosensitizer-for-in-vitro-pdt-of-melanoma
#11
Iman Gomaa, Aya Sebak, Nagia Afifi, Mahmoud Abdel-Kader
BACKGROUND: Cutaneous melanoma (CM) has substantially increased among Caucasian populations in the past few decades. This increased the number of CM deaths throughout the world. Pigmentation of melanoma reduces the efficacy of photodynamic therapy (PDT). Third generation photosensitizers (PSs) are characterized by improved targeting to the diseased tissue and reduced systemic side effects. This study is directed towards synthesis and characterization of liposomes encapsulating sodium ferrous chlorophyllin (Fe-CHL) and assessing its efficacy as a PS in PDT of melanoma...
February 24, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28238893/dna-analysis-of-cattle-parasitic-protozoan-tritrichomonas-foetus-after-photodynamic-therapy
#12
A Margraf-Ferreira, I C S Carvalho, S M Machado, C Pacheco-Soares, C W Galvão, R M Etto, N S da Silva
Photodynamic therapy (PDT) is a modality of therapy that involves the activation of photosensitive substances and the generation of cytotoxic oxygen species and free radicals to promote the selective destruction of target tissues. This study analyzed the application of PDT to Tritrichomonas foetus, a scourged and etiological agent of bovine trichomoniasis, a sexually transmitted infectious disease. As it is an amitochondrial and aerotolerant protozoan, it produces energy under low O2 tension via hydrogenosome...
February 23, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28254624/real-time-light-dosimetry-for-intra-cavity-photodynamic-therapy-application-for-pleural-mesothelioma-treatment
#13
Nacim Betrouni, Camille Munck, Wael Bensoltana, Grégory Baert, Anne-Sophie Dewalle-Vignion, Arnaud Scherpereel, Serge Mordon
Complete and homogeneous illumination of the target is necessary for the success of a photodynamic therapy (PDT) procedure. In most applications, light dosimetry is done using detectors placed at strategic locations of the target. In this study we propose a novel approach based on the combination of light distribution modeling with spatial localization of the light applicator for real time estimation and display of the applied dose on medical images. The feasibility approach is demonstrated for intrapleural PDT of malignant pleural mesothelioma...
February 22, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28232271/effect-of-laser-assisted-scaling-and-root-planing-on-the-expression-of-pro-inflammatory-cytokines-in-the-gingival-crevicular-fluid-of-patients-with-chronic-periodontitis-a-systematic-review
#14
REVIEW
Sergio Varela Kellesarian, Vanessa Ros Malignaggi, Hasham Abdullah Majoka, Abdulaziz A Al-Kheraif, Tammy Varela Kellesarian, Georgios E Romanos, Fawad Javed
BACKGROUND: The aim of the present systematic review was to assess the efficacy of laser-assisted (low level laser therapy [LLLT], high intensity laser therapy [HILT], or antimicrobial photodynamic therapy [aPDT]) scaling and root planing (SRP) compared with SRP alone on the expression of inflammatory cytokines in the gingival crevicular (GCF) of patients with chronic periodontitis (CP). METHODS: In order to address the focused question: "What is the efficacy of SRP with and without laser and/or aPDT on the expression of pro-inflammatory cytokines in the GCF of patients with CP?" an electronic search without time or language restrictions was conducted up to and including February 2017 in indexed databases using various key words...
February 20, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28232076/influence-of-iron-oxide-nanoparticles-fe3o4-on-erythrocyte-photohemolysis-via-photofrin-and-rose-bengal-sensitization
#15
M-Ali H Al-Akhras, Khaled Aljarrah, Borhan Albiss, Duaa Al-Khalili
BACKGROUND: Iron oxide (Fe3O4) nanoparticles (IO-NP) were recently employed in medical applications as a diagnostic and drug carrier. Photofrin (PF) is a photosensitizer that clinically used in Photodynamic therapy (PDT). STUDY DESIGN: the photosensitivity of the PF and Rose Bengal (RB) mixed with (IO-NP) on red blood cells (RBCs) lysis was investigated. Second, Photohemolysis for post-irradiation (delayed) and during irradiation (continuous) with PF, RB and IO-NP combinations at different concentrations was investigated...
February 19, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28223144/combination-of-hand-held-probe-and-microscopy-for-fluorescence-guided-surgery-in-the-brain-tumor-marginal-zone
#16
Johan Richter, Neda Haj-Hosseini, Martin Hallbeck, Karin Wårdell
BACKGROUND: Visualization of the tumor is crucial for differentiating malignant tissue from healthy brain during surgery, especially in the tumor marginal zone. The aim of the study was to introduce a fluorescence spectroscopy-based hand-held probe (HHF-probe) for tumor identification in combination with the fluorescence guided resection surgical microscope (FGR-micsorcope), and evaluate them in terms of diagnostic performance and practical aspects of fluorescence detection. METHODS: Eighteen operations were performed on 16 patients with suspected high-grade glioma...
February 18, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28223143/comparison-of-photoinactivation-of-t-rubrum-by-new-methylene-blue-nmb-and-indocyanine-green-emundo-%C3%A2
#17
Reza Fekrazad, Arash Poorsattar Bejeh Mir, Mina Kahyaie Aghdam, Vadood Ghasemi Barghi
BACKGROUND: Superficial mycotic skin infections which are predominantly caused by Trichophyton rubrum, poorly responses to conventional therapies. A great amount of attention has focused on to find more effective treatments. The current work is aimed to compare the effectiveness of phoinactivation of Trichophyton rubrum by two relatively new photosensitizers: a phenothiazinium dye(New methylene blue) and Indocyanine green (EmunDo(®)). MATERIALS AND METHODS: A Final inoculum of T...
February 18, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28219801/ala-photodynamic-treatment-in-lichen-sclerosus-clinical-and-immunological-outcome-focusing-on-the-assesment-of-anti-nuclear-antibodies
#18
Anita Olejek, Iwona Gabriel, Anna Bilska-Janosik, Iwona Kozak-Darmas, Aleksandra Kawczyk-Krupka
BACKGROUND: Lichen sclerosus (LS) is a difficult to treat, often relapsing disease with unknown background. An autoimmune diseases coexist with LS. Over recent years photodynamic therapy (PDT) has been shown to be noninvasive and successful therapeutic approach for the effective treatment many conditions. However, the change of immune status of the patients based on ANA antibodies has not been yet reported. Our aim was to observe the clinical response followed by possible changes in autoimmune antibodies levels before and after PDT...
February 17, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28216095/real-time-quantitative-reverse-transcription-pcr-analysis-of-expression-stability-of-aggregatibacter-actinomycetemcomitans-fimbria-associated-gene-in-response-to-photodynamic-therapy
#19
Maryam Pourhajibagher, Abbas Monzavi, Nasim Chiniforush, Mohammad Moein Monzavi, Shaghayegh Sobhani, Sima Shahabi, Abbas Bahador
BACKGROUND: Aggregatibacter actinomycetemcomitans is an etiological agent of both chronic and aggressive periodontitis. Dissemination of A. actinomycetemcomitans from the oral cavity and initiation of systemic infections has led to new approaches for treatment being needed. In this study, a series of experiments presented investigated the effect of methylene blue (MB)-mediated antimicrobial photodynamic therapy (aPDT) on cell viability and expression of fimbria-associated gene (rcpA) in A...
February 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28232036/effects-of-photodynamic-therapy-with-talaporfin-sodium-on-squamous-cell-carcinoma-and-sarcoma-cells
#20
Tomohiro Osaki, Yuki Kawase, Hiroshi Iseki, Shinji Kishimoto, Soko Ikuta, Yoshihiro Muragaki, Kazuo Azuma, Yusuke Murahata, Takeshi Tsuka, Norihiko Ito, Tomohiro Imagawa, Yoshiharu Okamoto
BACKGROUND: Photodynamic therapy (PDT) uses a photosensitizer and light to destroy abnormal cells. Talaporfin sodium (NPe6) is a second-generation photosensitizer. METHODS: We evaluated the toxic effects of different combinations of laser and NPe6 doses on squamous cell carcinoma (KLN205) and sarcoma (Meth A) cell lines. The cells were incubated with 0, 5, 10, or 30μg/mL NPe6 for 24h. The cells were then irradiated with 0, 5, 15, or 30mW/cm(2) of laser power, and 0, 1, 5, 10, or 20J/cm(2) of laser energy...
February 13, 2017: Photodiagnosis and Photodynamic Therapy
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