Read by QxMD icon Read

Photodiagnosis and Photodynamic Therapy

Darika Saitawee, Aroon Teerakapong, Noppawan Phumala Morales, Paiboon Jitprasertwong, Doosadee Hormdee
BACKGROUND AND OBJECTIVE: Curcumin, one of an established curcuminoid substances extracted from Curcuma longa, has been used as a photosensitizer (PS) in photodynamic therapy (PDT). Curcuminoid substances has been reported to have benefits in treating dental chronic infection and inflammation diseases, such as chronic periodontitis. The purpose of this study was to find the optimum concentration of Curcuma longa (CL) extract, containing all curcuminoid substances, and the power density of blue light (BL) in photodynamic therapy against periodontally pathogenic bacteria, A...
March 10, 2018: Photodiagnosis and Photodynamic Therapy
Aleksandra Kawczyk-Krupka, Zenon Czuba, Wojciech Latos, Katarzyna Wasilewska, Thomas Verwanger, Barbara Krammer, Aleksander Sieroń
BACKGROUND: Photodynamic therapy has apart from a direct cytotoxic effect also immunomodulatory properties. The aim of our study was to investigate how photodynamic therapy with 5-aminolevulinic acid (ALA-PDT) in sublethal doses influences the secretion of interleukins 6, 8 and 10 from colon cancer cells in vitro. METHODS: We used two human colon cancer cell lines SW480 and SW620 of different malignancies which were treated with a sublethal PDT protocol. Determination of interleukins was carried out using the Bio- Plex Assay Pro™ kit on the Bio- Plex Suspension Array System...
March 3, 2018: Photodiagnosis and Photodynamic Therapy
Larissa S Amaral, Eduardo B Azevedo, Janice R Perussi
Antimicrobial Photodynamic Inactivation (a-PDI) is based on the oxidative destruction of biological molecules by reactive oxygen species generated by the photo-excitation of a photosensitive molecule. When the a-PDT is performed along with the use of mathematical models, the optimal conditions for maximum inactivation are easily found. Experimental designs allow a multivariate analysis of the experimental parameters. This is usually made using a univariate approach, which demands a large number of experiments, being time and money consuming...
February 27, 2018: Photodiagnosis and Photodynamic Therapy
Gustavo Miranda Pires Santos, Susana C P S de Oliveira, Juliana C S Monteiro, Sandra R Fagnani, Fernando Pires Sampaio, Pedro J L Crugeira, Paulo Fernando Almeida, Antonio L B Pinheiro
The aim of this study was to evaluate the lethal potential of macrophages infected with Staphylococcus aureus after PACT using phenothiazine derivatives (a solution containing 1:1 methylene blue and O toluidine blue) and laser (660 nm, 40 mW, 60 s, 12 J/cm2 ) or LED (632 ± 2 nm, 145 mW, 40 s, 12 J/cm2 ). Six experimental groups were evaluated: Control Group (untreated); Photosensitizer group (phenothiazines - 12.5 μg/mL); Laser Group; LED Group; Laser PACT Group; and LED PACT Group. The pre-irradiation time used in this study was 5 minutes...
February 27, 2018: Photodiagnosis and Photodynamic Therapy
Fahad Alkhudhairy, Mustafa Naseem, Mohammed Bin-Shuwaish, Fahim Vohra
The aim was to evaluate the influence of Er, Cr: YSGG laser therapy at different pulse frequency and power levels on the bond strength and microleakage of bleached enamel. One hundred samples were bleached using in-office whitening agent. Bleached samples were divided into six subgroups, four subgroups was based on laser application parameters (pulse frequency 50 and 30 Hz; Power 4.5 & 6 W) one subgroup was treated with bleach (B) and the other was control (no bleaching, no laser application). All specimens including control were etched with 37% phosphoric acid and composite build-ups were performed...
February 24, 2018: Photodiagnosis and Photodynamic Therapy
Maryam Pourhajibagher, Abbas Bahador
BACKGROUND: It is essential to identify the root canal microbial diversity and count due to the polymicrobial nature of the primary endodontic infection that is associated with the microbial diversity and increased resistance to the antimicrobial agents. Photo-activated disinfection (PAD), also known as antimicrobial photodynamic therapy, is a new promising non-antibiotic approach, studied to prevent microbial resistance and treatment failure. MATERIALS AND METHODS: In this study, we investigated the effect of PAD on reduction of microbial diversity and count, related with primary endodontic infections...
February 24, 2018: Photodiagnosis and Photodynamic Therapy
Cennet Neslihan Eroglu, Serap Keskin Tunc, Remzi Erten, Aslıhan Usumez
BACKGROUND: Although antimicrobial efficacy of photodynamic therapy has been studied several times, there is no study investigating its efficacy on pericoronitis. This study aimed to determine whether antimicrobial photodynamic therapy combined with antibiotic therapy is clinically and histologically superior to antibiotic therapy alone in pericoronitis treatment. METHODS: Patients (n = 40) with pericoronitis were divided into two groups (20 patients for each) to receive either antibiotic + indocyanine green + 810 nm wavelength diode laser (antimicrobial photodynamic therapy group) or antibiotic alone...
February 24, 2018: Photodiagnosis and Photodynamic Therapy
Valdir Gouveia Garcia, Erivan Clementino Gualberto, Edilson Ervolino, Maria José Hitomi Nagata, Juliano Milanezi de Almeida, Letícia Helena Theodoro
No abstract text is available yet for this article.
February 23, 2018: Photodiagnosis and Photodynamic Therapy
Valerio De Vita
No abstract text is available yet for this article.
February 22, 2018: Photodiagnosis and Photodynamic Therapy
Lamiaa M A Ali, Emna Mathlouthi, Marilyn Kajdan, Morgane Daurat, Jérôme Long, Rahima Sidi-Boulenouar, Maïda Cardoso, Christophe Goze-Bac, Nourredine Amdouni, Yannick Guari, Joulia Larionova, Magali Gary-Bobo
Here we demonstrate for the first time that Mn2+ -doped Prussian blue nanoparticles of c.a. 70 nm act as effective agents for photothermal therapy under two-photon excitation with an almost total eradication of malignant cells (97 and 98%) at a concentration of 100 μg.mL-1 24 hours after NIR excitation. This effect combined with interesting longitudinal NMR relaxivity values offer new perspectives for effective imaging and cancer treatment.
February 22, 2018: Photodiagnosis and Photodynamic Therapy
Qian Zhang, Xiulian Xu, Rong Zeng, Wenbo Bu, Fang Fang
Skin squamous cell carcinoma is the second most common non-melanoma skin tumor worldwide. Most skin squamous cell carcinoma patients have underlying diseases. Here, we reported that a 56 year-old patient diagnosed by skin squamous cell carcinoma with a 30 year course of neglected lupus vulgaris, which was very rare. In this case, we adopted a treatment strategy involving a small wound: superficial resection combined with photodynamic therapy with a satisfied result.
February 21, 2018: Photodiagnosis and Photodynamic Therapy
Safdar Ali, Saleh Muhammad, Ahmat Khurshid, Masroor Ikram, Muhammad Maqsood, Carl Fisher, Judy Cathcart, Lothar Lilge
To improve a cancer patient's quality of life, short treatment duration resulting in rapid tumour removal while sparing normal tissue are highly desirable. Photodynamic therapy (PDT) commonly applied in a single treatment, while often effective can be limited at low photosensitizer or light doses. Combination therapies can overcome the efficacy limitations while not increasing treatment-associated morbidity. Here the efficacy of combination therapy comprised of doxorubicin (DOX) or methotrexate (MTX) with Photosens mediated PDT was investigated in three cell lines in vitro, employing multiple incubation sequences...
February 21, 2018: Photodiagnosis and Photodynamic Therapy
Fawad Javed, Danial Salehpoor, Talal Al-Dhafeeri, Muhammad Yousuf, Hans Malmstrom, Junad Khan, Zohaib Akram
BACKGROUND: To assess the impact of scaling and root planing (SRP) with and without adjunct photodynamic therapy (PDT) in the treatment of periodontal disease (PD) in hyperglycemic patients. METHODS: Databases (MEDLINE, EMBASE; and CENTRAL) were searched up to December 2017. The addressed PICO question was: "What is the effectiveness of adjunctive PDT to non-surgical periodontal treatment by means of clinical periodontal and glycemic parameters in hyperglycemic patients?" RESULTS: Four clinical trials and 1 experimental study were included...
February 19, 2018: Photodiagnosis and Photodynamic Therapy
Fernanda Mansano Carbinatto, Antonio Eduardo de Aquino, Vitória Helena Maciel Coelho, Vanderlei S Bagnato
In this report, we recent a case study on a 50-year-old male patient with different chronic wounds, such as venous ulcer and arterial ulcer in both legs. These wounds have persisted for more than 10 years, despite the different treatments applied, between safenectomy, different dressings, hyperbaric camera, as well as the used of several medicines of oral and topical application. The case is addressed with the aim to evaluate if treatment that uses combined techniques such as low level laser therapy (LLLT), photodynamic therapy and cellulose membrane is able to improve healing and reduction of time of treatment in those types of chronic wounds...
February 19, 2018: Photodiagnosis and Photodynamic Therapy
Edward V Maytin, Urvashi Kaw, Muneeb Ilyas, Judith A Mack, Bo Hu
BACKGROUND: Photodynamic therapy (PDT) is a non-scarring alternative for treating basal cell carcinoma (BCC) in patients with Basal Cell Nevus Syndrome (BCNS), also known as Gorlin syndrome. In Europe, red light (635 nm) is the predominant source for PDT, whereas in the United States blue light (400 nm) is more widely available. The objective of this study was to conduct a head-to-head comparison of blue light and red light PDT in the same BCNS patients. METHODS: In a pilot study of three patients with 141 BCC lesions, 5-aminolevulinate (20% solution) was applied to all tumors...
February 19, 2018: Photodiagnosis and Photodynamic Therapy
André Henrique Correia Pereira, Juliana Guerra Pinto, Mirian Aparecida Alves Freitas, Letícia Corrêa Fontana, Cristina Pacheco Soares, Juliana Ferreira-Strixino
Bacterial infections have been a major challenge to health studies, facing the increasingly resistance to antimicrobial agents, which according to World Health Organization, could be the major death cause until 2050. Photodynamic therapy emerges as an alternative in microbial inactivation, due to its selectivity and to decreasing or dismissing the antibiotic use. This study aimed at evaluating, in vitro, the internalization of the Methylene Blue and its photodynamic activity against a clinical and ATCC strain of Pseudomonas aeruginosa and Staphyloccocus aureus...
February 15, 2018: Photodiagnosis and Photodynamic Therapy
M Fernández-Guarino, M L González Morales, Israel Bernal, A I Sánchez Adrada, Sandra Pierri Ugia, J Barrio Garde
BACKGROUND: Photodynamic therapy (PDT) is a good option for the treatment of Bowen's disease (BD) but, BD occasionally develops into a squamous cell carcinoma (SCC) after PDT. OBJECTIVE: Find predictors of aggressiveness of BD after PDT METHODS: Two biopsies of patients with BD treated with PDT with progression to SCC within three months were selected for immunohistochemical (IHC) studies. Conventional PDT was applied. IHC analysis was performed together with hematoxylin-eosin in the biopsies prior to and after treatment with PDT...
February 15, 2018: Photodiagnosis and Photodynamic Therapy
Thaisa Helena Silva Fonseca, Marina Alacoque, Fabrício Marcus Silva Oliveira, Betânia Maria Soares, Henrique Vitor Leite, Marcelo Vidigal Caliari, Maria Aparecida Gomes, Haendel Busatti
The emergence of nitroimidazole resistant isolates has been an aggravating factor in the treatment of trichomoniasis, the most common non-viral sexually transmitted disease in the world. This particularity highlights the importance of new technologies that are safe, effective, and have minor side effects or resistance. Hence, we evaluated the effectiveness of photodynamic therapy on the inactivation of Trichomonas vaginalis in vitro. We used methylene blue as a photosensitizing substance, and a light-emitting diode (LED) for irradiation of metronidazole sensitive and resistant strains...
February 11, 2018: Photodiagnosis and Photodynamic Therapy
B Novak, L Heesen, N Schary, H Lübbert
BACKGROUND: Topical photodynamic therapy (PDT) is a highly effective therapy especially for extended cancerized fields of the skin. Whenever extended fields are treated pain management is advisable. Light source mediated pain management can be performed by reducing fluence rates, as long as this does not compromise efficacy. METHODS: Two squamous cell carcinoma cell lines (A431 and SCC-13) were subjected to in vitro PDT using two different ALA concentrations and synthesis intervals and protoporphyrin IX (PpIX) synthesis was assessed...
February 7, 2018: Photodiagnosis and Photodynamic Therapy
Hiroki Kurumi, Tsutomu Kanda, Koichiro Kawaguchi, Kazuo Yashima, Hiroki Koda, Kumi Ogihara, Kayoko Matsushima, Kazuhiko Nakao, Hiroaki Saito, Yoshiyuki Fujiwara, Mitsuhiko Osaki, Futoshi Okada, Hajime Isomoto
BACKGROUND/AIM: Laser-based photodynamic endoscopic diagnosis (LPDED) is a type of endoscopic diagnosis that uses the fluorescence caused by the photochemical reaction that occurs when a fluorescent substance is irradiated by a light of a specific wavelength. Although 5-aminolevulinic acid (5-ALA) can detect early gastric cancer (EGC) during LPDED, there is an unresolved issue of the differences in fluorescence intensity among histopathological types of gastric cancer. Thus, the aim of the present study was to assess whether protoporphyrinogen oxidase (PPOX), involved in the activation of protoporphyrin IX, can affect the fluorescence intensity in EGC...
February 6, 2018: Photodiagnosis and Photodynamic Therapy
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"