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Photodiagnosis and Photodynamic Therapy

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https://www.readbyqxmd.com/read/29129543/idiopathic-elastosis-perforans-serpiginosa-with-satisfactory-response-after-5-ala-photodynamic-therapy
#1
S Alique-García, J Company-Quiroga, C Horcajada-Reales, B Echeverría-García, J C Tardío-Dovao, J Borbujo
Photodynamic therapy (PDT) involves the use of photochemical reactions mediated through the interaction of photosensitizing agents, light, and oxygen for the treatment of malignant or benign diseases. Topical photosensitizers employed in dermatology are 5-aminolevulinic acid (5 ALA) and methyl aminolevulinate, classically used for the treatment of superficial non-melanoma skin cancer and their precursors. Recently the efficacy of PDT has been introduced in other benign diseases. Elastosis perforans serpiginosa (EPS) is a rare skin disorder characterized by transepidermal elimination of abnormal elastic fibers...
November 9, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29126959/nanocarriers-as-phototherapeutic-drug-delivery-system-appraisal-of-three-different-nanosystems-in-an-in-vivo-and-in-vitro-exploratory-study
#2
Eduardo Ricci-Junior, Luciana Betzler de Oliveira de Siqueira, Raphaela Aparecida Schuenck Rodrigues, Félix Sancenón, Ramón Martínez-Máñez, João Alfredo de Moraes, Ralph Santos-Oliveira
The use of nanosystem as diagnosing and therapy systems is increasing each year. There are several nanosystems available nowadays and the most prominent ones are: mesoporous silica, nanoemulsion and polymeric nanoparticles due to its characteristics, like low toxicology, and easy-producing process. They all have advantages when compared with the traditional system used, since they show specific targeting, controlled release, and higher penetration. In this study were tested three different nanocarriers (polymeric nanoparticles, nanoemulsion and mesoporous silica) containing phthalocyanineas possible PDT drugs (nanodrugs)...
November 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29126958/effects-of-led-based-photodynamic-therapy-using-red-and-blue-lights-with-natural-hydrophobic-photosensitizers-on-human-glioma-cell-line
#3
Zahra Jamali, Sedigheh Marjaneh Hejazi, Seyed Mohsen Ebrahimi, Hemen Moradi-Sardareh, Maliheh Paknejad
Photodynamic therapy (PDT) has received high attention in cancer treatment due to its minimal side effects, specific cancer-targeting, non-invasion and low cost. It utilizes a specific group of anti-cancer drugs called photosensitizers (PS), which can be only activated under a certain wavelength light illumination and kills cancer cells. To screen the potential of PS and setup of PDT treatment protocol, it is essential to assess the PDT efficacy in vitro. In this study, a light-emitting diode- (LED-) based illumination system at two wavelengths (red & blue) with homogeneous and stable irradiation, and constant temperature conditions in 96-well plates was provided...
November 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29113960/lesion-oxygenation-associates-with-clinical-outcomes-in-premalignant-and-early-stage-head-and-neck-tumors-treated-on-a-phase-1-trial-of-photodynamic-therapy
#4
Peter H Ahn, Jarod C Finlay, Shannon M Gallagher-Colombo, Harry Quon, Bert W O'Malley, Gregory S Weinstein, Ara Chalian, Kelly Malloy, Thomas Sollecito, Martin Greenberg, Charles B Simone, Sally McNulty, Alexander Lin, Timothy C Zhu, Virginia Livolsi, Michael Feldman, Rosemarie Mick, Keith A Cengel, Theresa M Busch
BACKGROUND: We report on a Phase 1 trial of photodynamic therapy (PDT) for superficial head and neck (H&N) lesions. Due to known oxygen dependencies of PDT, translational measurements of lesion hemoglobin oxygen saturation (StO2) and blood volume (tHb) were studied for associations with patient outcomes. METHODS: PDT with aminolevulinc acid (ALA) and escalating light doses was evaluated for high-grade dysplasia, carcinoma-in-situ, and microinvasive carcinomas of the H&N...
November 4, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29102653/combination-vismodegib-and-photodynamic-therapy-for-multiple-basal-cell-carcinomas
#5
Jason M Rizzo, Robert J Segal, Nathalie C Zeitouni
BACKGROUND: Oral vismodegib therapy and photodynamic therapy (PDT) are non-invasive treatments for basal cell carcinoma (BCC) with overlapping utility in widespread BCCs and patients who are poor surgical candidates. There is no published study to date investigating the combination use of PDT with vismodegib to optimize individual response rates. OBJECTIVE: To evaluate the combination of red light PDT and vismodegib therapy in patients with multiple nodular BCCs...
November 1, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29102652/photodynamic-therapy-using-pheophorbide-and-670nm-leds-exhibits-anti-cancer-effects-in-vitro-in-androgen-dependent-prostate-cancer
#6
Taher Gheewala, Troy Skwor, Gnanasekar Munirathinam
Prostate cancer (PCa) is the third leading cause of death in men in the United States and its treatment options include surgery, anti-hormonal drugs for androgen sensitive tumors, and radiotherapy. An alternative treatment is the use of photodynamic therapy (PDT), which involves the activation of a photosensitizer by a defined wavelength of light in the presence of oxygen, generating transient concentrations of reactive oxygen species (ROS). In this study, we explored the anti-cancer potential and mechanism of action of PDT using pheophorbide (Pheo) as a photosensitizer in combination with 670nm LEDs...
November 1, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29102651/development-of-a-fluorescence-image-scoring-system-for-assessing-noncavitated-occlusal-caries
#7
Eun-Ha Jung, Eun-Song Lee, Hoi-In Jung, Si-Mook Kang, Elbert de Josselin de Jong, Baek-Il Kim
BACKGROUND: This study aimed (1) to develop a scoring system based on a quantitative light-induced fluorescence (QLF) score for the occlusal region (QS-Occlusal) that standardizes the fluorescence properties of noncavitated lesions from QLF images, (2) to confirm the validity and reliability of QS-Occlusal, and (3) to determine whether it is possible to replace existing clinical examinations by image evaluations based on the developed QS-Occlusal for assessing occlusal caries lesions...
November 1, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29101088/effect-of-methylene-blue-induced-photodynamic-therapy-on-a-streptococcus-mutans-biofilm-model
#8
Mariana Alencar Nemezio, Sofia Sampaio de Souza Farias, Maria Cristina Borsatto, Carolina Patrícia Aires, Silmara Aparecida Milori Corona
BACKGROUND: Several studies have reported the use of antimicrobial photodynamic therapy (aPDT) to control biofilm but its efficacy depends on several factors, such as biofilm model used. This study aims to examine whether exposure to diode laser combined with methylene blue affects the bacterial viability and polysaccharide content in a Streptococcus mutans cariogenic biofilm model, which simulated 'feast-famine' episodes of exposure to sucrose that occur in the oral cavity. MATERIALS AND METHODS: S...
October 31, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29097290/in-vitro-evaluation-of-methylene-blue-removal-from-root-canal-after-photodynamic-therapy
#9
Karen Müller Ramalho, Sandra Ribeiro Cunha, Eric Mayer-Santos, Carlos de Paula Eduardo, Patricia Moreira de Freitas, Ana Cecilia Correa Aranha, Cacio Moura-Netto
In Endodontics, photosensitizers' such as methylene blue and toluidine blue have been used in photodynamic therapy due to their positive results. However, they can stain the dentin from the root canal after Photodynamic Therapy (PDT). The present in vitro study aimed to evaluate different stain removal protocols from root canal after PDT using methylene blue (MB) dye. After mechanical preparation of the root canal of 40 uni-radicular human teeth, PDT was performed using 0,01% MB with parameters of 3minutes of pre-irradiation and a diode laser irradiation emitting at 660nm, 40mW, 4minutes, 9...
October 30, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29107824/antimicrobial-photodynamic-therapy-apdt-and-photobiomodulation-pbm-660nm-in-a-dog-with-chronic-gingivostomatitis
#10
Paula Abreu Villela, Naiá de Carvalho de Souza, Juliana Durigan Baia, Marco Antonio Gioso, Ana Cecília Corrêa Aranha, Patrícia Moreira de Freitas
Chronic gingivostomatitis in dogs is an inflammatory syndrome of the oral cavity, which treatment and control of concomitant periodontitis allow healing in most of the cases. In the presence of recurrent lesions, invasive methods are necessary to treat lesions and pain. As a conservative adjuvant method, photobiomodulation (PBM) with low power laser is able to promote reduction of tissue pain and tissue inflammation besides increasing vascularization and healing, restoring the normal function of the irradiated organ in a shorter time...
October 28, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29107823/photodynamic-therapy-for-an-iris-metastasis-from-pulmonary-adenocarcinoma
#11
Yanyan Chen, Yuedong Hu
Uveal metastasis is the most common intraocular malignancy. Lung cancer is one of the most common malignancies that metastasize to uvea. Iris involvement is rarely reported. Here we report a case of iris metastasis from pulmonary adenocarcinoma that was treated with photodynamic therapy (PDT). A 65-year-old Chinese man was referred to our hospital for iris white neoplasm and blurred vision for 2 weeks in his right eye. His accepted pulmonary lobectomy, radiotherapy and chemotherapy for pulmonary adenocarcinoma 1year ago and liver metastases were found 2 months earlier...
October 28, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29111391/short-term-effects-of-adjunctive-antimicrobial-photodynamic-therapy-in-obese-patients-with-chronic-periodontitis-a-randomized-controlled-clinical-trial
#12
Fahim Vohra, Zohaib Akram, Ishfaq A Bukhari, Saeed A Sheikh, Fawad Javed
BACKGROUND: The aim of the present study was to assess the effect of antimicrobial photodynamic therapy (aPDT) as an adjunct to scaling and root planing (SRP) on clinical periodontal and immunological parameters in obese patients with chronic periodontitis (CP). METHODS: Fifty-three obese with CP patients were divided into 2 groups receiving aPDT with SRP and SRP only respectively. Full-mouth plaque index (PI), bleeding on probing (BOP), pocket depth (PD) and clinical attachment level (CAL) were assessed at baseline, 6 and 12 weeks post-therapy...
October 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29111390/treatment-of-peritoneal-carcinomatosis-with-photodynamic-therapy-systematic-review-of-current-evidence
#13
REVIEW
Muhammad Qutayba Almerie, Gemma Gossedge, Kathleen E Wright, David G Jayne
BACKGROUND: Peritoneal carcinomatosis results when tumour cells implant and grow within the peritoneal cavity. Treatment and prognosis vary based on the primary cancer. Although therapy with intention-to-cure is offered to selective patients using cytoreductive surgery with chemotherapy, the prognosis remains poor for most of the patients. Photodynamic therapy (PDT) is a cancer-therapeutic modality where a photosensitiser is administered to patients and exerts a cytotoxic effect on cancer cells when excited by light of a specific wavelength...
October 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29111389/antifungal-photosensitive-activity-of-porophyllum-obscurum-spreng-dc-correlation-of-the-chemical-composition-of-the-hexane-extract-with-the-bioactivity
#14
Agustina Postigo, Matías Funes, Elisa Petenatti, Hebe Bottai, Adriana Pacciaroni, Maximiliano Sortino
In this paper, we report Porophyllum obscurum as a source of new photosensitizers with potential use in Photodynamic Therapy as an alternative for oropharyngeal candidiasis treatment. The antifungal photosensitive activity of different extracts from P. obscurum was evaluated by using microdilution and bioautographic assays. The Minimum Fungicidal Concentration for hexanic extract under UV-A irradiation was 0.98μg/mL, but it was inactive in experiments without irradiation. The bioassay-guided fractionation of this extract led to the isolation of four thiophenes responsible for the photosensitive activity: 2,2':5'2″terthiophene, 5-(3-buten-1-ynyl)-2,2'-bithiophene, 5-(4-acetoxy-1-butenyl)-2,2'- bithiophene and 5-(4-hydroxy-1-butenyl)-2,2'- bithiophene, with Minimum Fungicidal Concentrations ranging 0...
October 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29079353/photodynamic-therapy-using-a-cytotoxic-photosensitizer-porphyrus-envelope-that-targets-the-cell-membrane
#15
Mizuho Inai, Norihiro Honda, Hisanao Hazama, Sharmin Akter, Shinichiro Fuse, Hiroyuki Nakamura, Tomoyuki Nishikawa, Yasufumi Kaneda, Kunio Awazu
BACKGROUND: Subcellular localization of a photosensitizer is known to determine the therapeutic efficacy of photodynamic therapy (PDT). Cell membrane is an optimal target that promises an effective treatment outcome. OBJECTIVES: We previously developed a novel photosensitizer named porphyrus envelope (PE) by combining hemagglutinating virus of Japan envelope (HVJ-E) with lipidated protoporphyrin IX (PpIX lipid). In the current study, the cellular localization of PE and its ability to induce multiple anti-tumor effect were characterized...
October 24, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29079352/intense-phototoxic-reactions-to-photodynamic-therapy-in-immunosuppressed-renal-transplant-patients
#16
V K Ortner, M Haedersdal, H C Wulf, K Togsverd-Bo
No abstract text is available yet for this article.
October 24, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29079351/photodynamic-therapy-for-the-treatment-of-peri-implant-diseases-a-network-meta-analysis-of-randomized-controlled-trials
#17
REVIEW
Gowri Sivaramakrishnan, Kannan Sridharan
BACKGROUND: Photodynamic therapy in peri-implantitis has been tested in randomized clinical trials. Though systematic review and meta-analysis on human and animal studies, identifies the utility of photodynamic therapy, a comparison of other interventions with photodynamic therapy for peri-implantitis does not exist. Hence the aim of this network meta-analysis is to identify the role of photodynamic therapy for peri-implantitis compared with other interventions tested in randomized human clinical trials...
October 24, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29079350/clinical-study-on-clinical-operation-and-post-treatment-reactions-of-hmme-pdt-in-treatment-of-pws
#18
REVIEW
Yunjie Zhang, Xianbiao Zou, Hongxia Chen, Yuguang Yang, Hui Lin, Xiaojuan Guo
OBJECTIVE: To analyze the clinical efficacy of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) in treating port-wine stains (PWS), and its clinical operation skills and operation essentials. METHOD: A total of 16 cases of PWS with negative HMME skin test results were included in this study. Their treated areas were exposed and injected with 5mg/kg HMME, and then irradiated under 532nm LED green light, with the irradiation power density between 90-100mW/cm(2)...
October 24, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29079349/a-new-screening-method-to-detect-proximal-dental-caries-using-fluorescence-imaging
#19
Eun-Soo Kim, Eun-Song Lee, Si-Mook Kang, Eun-Ha Jung, Elbert de Josselin de Jong, Hoi-In Jung, Baek-Il Kim
OBJECTIVES: This study aimed to assess the screening performance of the quantitative light-induced fluorescence (QLF) technology to detect proximal caries using both fluorescence loss and red fluorescence in a clinical situation. Moreover, a new simplified QLF score for the proximal caries (QS-Proximal) is proposed and its validity for detecting proximal caries was evaluated as well. METHODS: This clinical study included 280 proximal surfaces, which were assessed by visual-tactile and radiographic examinations and scored by each scoring system according to lesion severity...
October 24, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29079348/secretion-of-the-angiogenic-factor-vegf-after-photodynamic-therapy-with-ala-under-hypoxia-like-conditions-in-colon-cancer-cells
#20
Aleksandra Kawczyk-Krupka, Beata Kwiatek, Zenon Czuba, Anna Mertas, Wojciech Latos, Thomas Verwanger, Barbara Krammer, Aleksander Sieroń
BACKGROUND: Photodynamic therapy (PDT), eliminates not only the tumor, but also modulates signaling factors release, e.g. vascular endothelial growth factor (VEGF), which plays a crucial role in cancer progression. Assessment of the VEGF-secreting activity of resistant colon cancer cells in different degree of malignancy: SW480 and SW620 under hypoxia-like conditions during δ- aminolevulinic acid (ALA) PDT was the objective of our study. METHODS: The colon cancer cell lines SW480 and SW620 were treated in sublethal doses with ALA PDT in hypoxia- like conditions with cobalt chloride (CoCl2)...
October 24, 2017: Photodiagnosis and Photodynamic Therapy
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