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Photodiagnosis and Photodynamic Therapy

Saranjam Khan, Rahat Ullah, Asifullah Khan, Ruby Ashraf, Hina Ali, Muhammad Bilal, Muhammad Saleem
This study presents the analysis of hepatitis B virus (HBV) infection in human blood serum using Raman spectroscopy combined with pattern recognition technique. In total 119 confirmed samples of HBV infected sera, collected from Pakistan Atomic Energy Commission (PAEC) general hospital have been used for the current analysis. The differences between normal and HBV infected samples have been evaluated using support vector machine (SVM) algorithm. SVM model with two different kernels i.e. polynomial function and Gaussian radial basis function (RBF) have been investigated for the classification of normal blood sera from HBV infected sera based on Raman spectral features...
May 19, 2018: Photodiagnosis and Photodynamic Therapy
Ceren Sarı, Figen Celep Eyüpoğlu, İsmail Değirmencioğlu, Rıza Bayrak
Photodynamic therapy is one of the hot topics in cancer studies recently. Basically, photosensitizing chemical substrates which are stimulated by light having a specific wavelength cause fatal effect on different kind of cells in photodynamic therapy. In this study, axially 4-{[(1E)-2-furylmethylene]amino}phenol, 4-{[(1E)-2-thienylmethylene]amino}phenol and 4-{[(1E)-(4-nitro-2-thienyl)methylene]amino}phenol disubstituted silicon phthalocyanines were synthesized as Photosensitizers for photodynamic therapy in cancer treatment for the first time...
May 15, 2018: Photodiagnosis and Photodynamic Therapy
Stéphane Derruau, Yohann Renard, Hervé Pron, Redha Taiar, Ellie Abdi, Guillaume Polidori, Sandrine Lorimier
Hidradenitis suppurativa (HS) is a chronic, inflammatory, and recurrent skin disease. Surgical excision of wounds appears to be the only curative treatment for the prevention of recurrence of moderate to severe stages. Magnetic resonance imaging (MRI) is a standard reference examination for the detection of HS peri-anal inflammatory fistula. In this case study, the use of real-time medical infrared thermography, in combination with MRI as appropriate imaging, is proposed. The aim is to assist surgeons in the pre- and peri-surgical management of severe perianal hidradenitis suppurativa with the intent to ensure that all diseased lesions were removed during surgery and therefore to limit recurrence...
May 12, 2018: Photodiagnosis and Photodynamic Therapy
Laíse Midori Tokubo, Pedro Luiz Rosalen, Janaina de Cássia Orlandi Sardi, Irlan Almeida Freires, Mitsue Fujimaki, Josely Emiko Umeda, Patricia Magalhães Barbosa, Gabriela Ortolan Tecchio, Noboru Hioka, Camila Fabiano de Freitas, Raquel Sano Suga Terada
BACKGROUND: Photodynamic therapy (PDT) has demonstrated promising results in the treatment of several clinical pathologies through the photochemical reaction caused by the combination of a photosensitizer and a light source. The objective of this study was to evaluate the antimicrobial effect of the combination of the photosensitizers (PSs) erythrosine/methylene blue activated by a white halogen light device on Streptococcus mutans biofilm. METHODS: Two separate experiments were conducted, the first using the PSs at the concentration of 100 μM, and the second 250 μM...
May 12, 2018: Photodiagnosis and Photodynamic Therapy
Hee-Eun Kim, Baek-Il Kim
PURPOSE: The aim of thisin situ study was to measure baseline fluorescence loss values (ΔF(0) ) using the quantitative light-induced fluorescence (QLF) technology to screen enamel lesions for effective remineralization following fluoride application. METHODS: In this single-blindedin situ study, 20 adult volunteers wore intraoral appliances containing 4 specimens of human enamel. The surfaces of the specimens were divided into 3 regions: sound, demineralized, and treated regions...
May 12, 2018: Photodiagnosis and Photodynamic Therapy
Khulud Abdulrahman Al-Aali
BACKGROUND: The present study systematically reviewed the literature to investigate the effect of phototherapy on the shear bond strength (SBS) of resin cement to zirconia ceramic. METHODS: electronic databases including MEDLINE (PubMed), ISI Web of Science, Scopus, ScIELO, LILACS and EMBASE until April 2018. The addressed focused question was: Does phototherapy increase the SBS of resin cement to zirconia ceramics?" RESULTS: A total of 8 in-vitro studies were included in the qualitative and quantitative analysis...
May 11, 2018: Photodiagnosis and Photodynamic Therapy
Stephen Rogers, Kiyonobu Honma, Thomas S Mang
BACKGROUND: Porphyromonas gingivalis and Treponema denticola are both principally implicated in the incidence of both periodontal disease and peri-implantitis. Recent studies have demonstrated that these bacteria exhibit symbiotic growth in vitro and a synergistic virulence in co-infection of animal models. Found at varying depths throughout the biofilm, these bacteria present a significant challenge to traditional antimicrobial treatment modalities. Antimicrobial photodynamic therapy ( aPDT ) has yielded high success against bacterial biofilms, namely those found in the oral cavity...
May 10, 2018: Photodiagnosis and Photodynamic Therapy
Yongxian Su, Jiawei Wu, Yu Gu
OBJECTIVE: To evaluate the efficacy and safety between photodynamic therapy (PDT) combined with intravitreal ranibizumab (IVR) and ranibizumab monotherapy in treating wet age-related macular degeneration (AMD). METHODS: A systematic search was performed in the PubMed, Embase, Web of Science and the Cochrane Library databases through December 31, 2017. The methodological quality of the references was evaluated according to the Cochrane quality assessment. RevMan 5...
May 9, 2018: Photodiagnosis and Photodynamic Therapy
Débora P Aureliano, José Angelo Lauletta Lindoso, Sandra Regina de Castro Soares, Cleusa Fumika Hirata Takakura, Thiago Martini Pereira, Martha Simões Ribeiro
Antiparasitic photodynamic therapy (ApPDT) is an emerging approach to manage cutaneous leishmaniasis (CL) since no side effects, contraindications and parasite resistance have been reported. In addition, methylene blue (MB) is a suitable photosensitizer to mediate ApPDT on CL. In this study we aimed to look for the best parameters to eradicate Leishmania amazonensis and investigated the cell death pathways involved in MB-mediated ApPDT. MB uptake by parasites was determined using different MB concentrations (50, 100, 250 and 500 μM) and incubation times (10, 30 and 60 min)...
May 8, 2018: Photodiagnosis and Photodynamic Therapy
Abdulaziz M Albaker, Aws S ArRejaie, Mohammed Alrabiah, Khulud Abdulrahman Al-Aali, Sameer Mokeem, Mohammed N Alasqah, Fahim Vohra, Tariq Abduljabbar
BACKGROUND: To evaluate the effects of single application of antimicrobial photodynamic therapy (aPDT) as an adjunct to open flap debridement (OFD) and OFD alone in patients with peri-implantitis (PI). MATERIALS AND METHODS: Twenty four patients with PI were divided into 2 groups receiving aPDT with OFD and OFD alone respectively. Peri-implant plaque index (PI), bleeding on probing (BOP), pocket depth (PD) and marginal bone level (MBL) were assessed at baseline, 6 and 12 months post-therapy...
May 5, 2018: Photodiagnosis and Photodynamic Therapy
Yongxian Lai, Haiyan Zhang, Minglei Wei, Jie Ji, Lei Shi, Peiru Wang, Bo Wang, Zheng Huang, Xiuli Wang
OBJECTIVE: To study the curative effect of red-light 5-Aminolevulinic photodynamic therapy(ALA-PDT) to port wine stains(PWS) on comb animal model. METHODS: 160 male cocks were randomly divided into 16 groups. The ALA only group was given ALA only topical or systemic application. Light only groups were only given 630 nm red light irradiation with different light density. ALA-PDT groups were given red light after the application of topical or systemic ALA. PDL group was given PDL irradiation...
May 5, 2018: Photodiagnosis and Photodynamic Therapy
Jeanette Kaae, Peter Alshede Philipsen, Hans Christian Wulf
INTRODUCTION: Necrobiosis lipoidica (NL) is a rare, treatment-resistant, granulomatous skin disease of unknown origin, frequently seen in patients with diabetes. METHODS: In this retrospective study we evaluated the long-term efficacy of methyl aminolaevulinate-based photodynamic therapy (MAL-PDT), including 80 treatments (70 conventional and 10 daylight PDT), on 65 unselected NL patients treated routinely in our clinic. Superficial curettage, avoiding skin oozing or bleeding, was performed prior to MAL application...
May 4, 2018: Photodiagnosis and Photodynamic Therapy
Aleksandra Kawczyk-Krupka, Barbara Pucelik, Anna Międzybrodzka, Aleksander Sieroń, Janusz M Dąbrowski
Infected leg ulcers are painful, debilitating and immensely reducing patient's quality of life, therefore they are becoming a more and more significant clinical and socioeconomic problems nowadays. Increasing resistance to antibiotics, drugs and therapies is one of the most urgent challenge in medicine worldwide and requires searching for a new, innovative and more efficient medical strategies. One of the opportunities for the cure of leg ulcers is photodynamic inactivation (PDI), that has been widely used in the treatment of various bacterial, fungal and viral infections...
May 3, 2018: Photodiagnosis and Photodynamic Therapy
Flávia Isabela Barbosa, Patrícia Valente Araújo, Lucas José Campos Machado, Cláudia Silami Magalhães, Milena Maria Moreira Guimarães, Allyson Nogueira Moreira
BACKGROUND: This pilot study aimed to evaluate the effect of antimicrobial photodynamic therapy (aPDT) as an adjuvant to non-surgical periodontal therapy (NSPT) on periodontal status and glycemic control in patients with type 2 diabetes mellitus and generalized chronic periodontitis. METHODS: Twelve patients were evaluated at five time points: during the preparation of the patient (T0), during the treatment phase (T1) and after 30 (T2), 90 (T3) and 180 (T4) days...
April 27, 2018: Photodiagnosis and Photodynamic Therapy
Viviana Teresa Orlandi, Eleonora Martegani, Fabrizio Bolognese
BACKGROUND: Pseudomonas aeruginosa is the etiological agent of systemic and skin infections that are often difficult to treat. Photodynamic therapy (PDT) and, more recently, phototherapy (PT), are emerging among antimicrobial treatments to be combined with antibiotics. Visible light, either alone or combined with a photosensitizer (PS), elicits photooxidative stress that induces microbial death. The response of bacteria to phototherapy seems to involve the antioxidant machinery. This study relies on the effects of detoxifying catalase A (KatA) in response to PDT and PT-induced photooxidative stress...
April 27, 2018: Photodiagnosis and Photodynamic Therapy
Behnam Bolhari, Maryam Pourhajibagher, Farzaneh Bazarjani, Nasim Chiniforush, Mehdi Rostami Rad, Salma Pirmoazen, Abbas Bahador
BACKGROUND: It has clearly demonstrated that Enterococcus faecalis, as a persistent microorganism is the major agent in the etiopatogeny of endodontic infections. Recently, the limitations of conventional endodontic therapy have given rise to many attempts to introduce antimicrobial photodynamic therapy (aPDT) as an alternative treatment. The aim of this study was to analyze the ex vivo effect of aPDT in combination with 2.0 % chlorhexidine (CHX) as a conventional therapy on colony count and expression patterns of genes associated with biofilm formation of E...
April 27, 2018: Photodiagnosis and Photodynamic Therapy
Yunjie Zhang, Yuguang Yang, Xianbiao Zou
Hidradenitis suppurativa/acne inversa (HS/AI) is a type of chronic suppurative inflammatory reaction of the hair follicles characterized by recurrent dermal abscesses, sinus tracts and scars. So far, there has not been any prospective study proving the efficacy and safety of photodynamic therapy for the disease. In this report, one case of HS/AI achieved resolution of skin lesions, ulcer healing and disappearance of symptoms after nine treatments with 5-aminolevulinic acid photodynamic therapy (ALA-PDT).
April 27, 2018: Photodiagnosis and Photodynamic Therapy
Shaila Mudambi, Paula Pera, Deschana Washington, Eva Remenyik, Eszter Fidrus, Gal Shafirstein, David Bellnier, Gyorgy Paragh
Photodynamic therapy (PDT) is an office-based treatment for precancerous and early cancerous skin changes. PDT induces cell death through the production of reactive oxygen species (ROS). Cyclobutane pyrimidine dimers (CPDs) are the most important DNA changes responsible for ultraviolet (UV) carcinogenesis. Recently ROS induced by UVA were shown to generate CPDs via activating melanin. This raised the possibility that PDT induced ROS may also induce CPDs and mutagenesis in melanin containing cells. Previously the effect of PDT on CPDs in melanin containing cells has not been assessed...
April 24, 2018: Photodiagnosis and Photodynamic Therapy
Maria F Costa Pedro, Alessandro S Kalck, Kevin F Dos Santos, Marcos S Sousa, Karla B Romio, Paula C S Souto, Josmary R Silva, Nara C de Souza
The use of the layer-by-layer (LbL) deposition technique allows materials, such as drugs, to be self-assembled in multilayers with other electrolytes by combining their properties in a nanostructured system. Triclosan (TCS) is commonly used as a drug because of its bactericidal action, while erythrosine (ERY) has been used as a photosensitizer in photodynamic therapies because of its high light absorptivity in the visible region of the electromagnetic spectrum. The major advantage of investigating systems immobilized in LbL films is the benefit of characterizing the interaction through available substances in solid state techniques...
April 21, 2018: Photodiagnosis and Photodynamic Therapy
Joanna Bartosińska, Katarzyna Wolska, Agnieszka Gerkowicz, Marta Niewiedzioł, Małgorzata Michalska- Jakubus, Małgorzata Komza, Tomasz Klepaczewski, Mirosław Kwaśny, Dorota Krasowska
BACKGROUND: Superluminescent diodes (sLED) appear to be an innovative and promising light source in photodynamic therapy (PDT), especially in actinic keratosis (AK) lesions treatment. AIM: Assessment of tolerability and efficacy of sLED in topical 5-aminolevulinic acid (ALA) PDT of AK lesions. METHODS: 27 patients received ALA PDT with the use of sLED with "soft starter". RESULTS: Tolerability of sLED lamp depended on the treated lesions field (extension) rather than on their thickness...
April 20, 2018: Photodiagnosis and Photodynamic Therapy
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