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Photodiagnosis and Photodynamic Therapy

Katie A O'Connell, Jean-Phillip Okhovat, Nathalie C Zeitouni
The aim of this review is to provide clinicians with an overview of outcomes in the current literature concerning the use of Photodynamic Therapy to treat Bowen's Disease, also known as Squamous Cell Carcinoma in situ. The review discusses clinical response, recurrence rates, cosmetic outcomes, and adverse effects. Strong evidence shows that PDT is an effective therapy for SCCis with acceptable clinical response rates and lower recurrence rates in comparison to conventional therapies such as cryotherapy and 5-fluorouracil...
September 18, 2018: Photodiagnosis and Photodynamic Therapy
Daniela Alejandra Cusicanqui Méndez, Eliézer Gutierres, Evandro José Dionisio, Marília Afonso Rabelo Buzalaf, Rodrigo Cardoso Oliveira, Maria Aparecida Andrade Moreira Machado, Thiago Cruvinel
BACKGROUND: To our knowledge, there is a lack of evidence on the effect of Antimicrobial Photodynamic Therapy (aPDT) by the application of curcumin against complex biofilms of dental caries lesions. In this sense, this study aimed to evaluate the viability, vitality, and acid metabolism of infected dentin caries microcosms treated with curcumin-mediated aPDT. METHODS: After microcosm biofilms growing anaerobically on bovine dentin disks immersed in McBain medium with 1% sucrose at 37 °C for 5 days, the biofilms were treated by the association of DMSO water solution or 600 μmol...
September 18, 2018: Photodiagnosis and Photodynamic Therapy
Jiliang Zhang, Shaojuan Zhang, Yang Liu, Meng Su, Xiaoxi Ling, Funan Liu, Yinghui Ge, Mingfeng Bai
Triple negative breast cancer (TNBC) is the deadliest form of breast cancer because compared with other types of breast cancer, it is more aggressive, diagnosed at later stage and more likely to develop recurrence. Many patients do not experience adequate tumor control after current clinical treatments involving surgical removal, chemotherapy and/or radiotherapy, leading to disease progression and significantly decreased quality of life. Here we report a new combinatory therapy strategy involving cannabinoid-based medicine and photodynamic therapy (PDT) for the treatment of TNBC...
September 18, 2018: Photodiagnosis and Photodynamic Therapy
Naira Maria Rebelatto Bechara Andere, Nídia Cristina Castro Dos Santos, Cássia Fernandes Araujo, Ingrid Fernandes Mathias, Amanda Rossato, Andréa Carvalho de Marco, Milton Santamaria, Maria Aparecida Neves Jardini, Mauro Pedrine Santamaria
BACKGROUND: This study's aim was to evaluate the local effect of clarithromycin associated with antimicrobial photodynamic therapy (aPDT) in the treatment of generalized aggressive periodontitis. MATERIALS AND METHODS: The study sample comprised 72 periodontal pockets on single-rooted teeth in multiple quadrants, with both probing depth and clinical attachment level ≥ 5 mm, and with bleeding on probing. The pockets were randomly distributed into four groups (n = 18 each) that received ultrasonic periodontal debridement in addition to placebo (the UPD group), systemic clarithromycin (the UPD + CLM group), aPDT (the UPD + aPDT group), or both systemic clarithromycin and aPDT (the UPD + CLM + aPDT group)...
September 15, 2018: Photodiagnosis and Photodynamic Therapy
Maryam Pourhajibagher, Leili Beytollahi, Roghayeh Ghorbanzadeh, Abbas Bahador
BACKGROUND: Dental caries is a disease caused by a group of oral streptococcal microorganisms, primarily Strptococcus mutans. Photoactivated disinfection (PAD) has been proposed as a conservative method for treatment of carious lesions. Therefore, the aim of this study was to assess the effectiveness of indocyanine green (ICG)- and toluidine blue O (TBO)-PAD as supplementary tools in reducing the bacterial load and expression profiling of the gene associated with the biofilm formation in S...
September 14, 2018: Photodiagnosis and Photodynamic Therapy
Augusto Alberto Foggiato, Douglas Fernandes Silva, Renata Cristina Faria Ribeiro Castro
The objective was to develop, characterize and test a box containing light emission diode (LED), Patent Deposit MU-BR20.2017.002297-3, which was named "Photodynamic Inactivation Device" (PID) and verify if it's suitable in microbial reduction or disinfection action of solid surfaces using PID. The equipment was made in a container of polypropylene with a lid of the same material and, for a better use of irradiation the internal part was covered with a layer of reflective aluminum. In addition, sixty boards of red LED 660 nm wavelength, containing three radiators each, for which the distribution of irradiation and spectral irradiance in all of the six internal faces were calculated in this device...
September 13, 2018: Photodiagnosis and Photodynamic Therapy
Fábio Parra Sellera, Ronaldo Gomes Gargano, Carolina Dos Anjos, Maurício da Silva Baptista, Martha Simões Ribeiro, Fabio Celidonio Pogliani
No abstract text is available yet for this article.
September 11, 2018: Photodiagnosis and Photodynamic Therapy
Xian He, Junbo Zhang, Liuchang Tan, Wensheng Wang, Yanying Song, Hailin Wang, Xincun Zhang, Huiling Kou, Yuangang Lu
BACKGROUND: Verrucous carcinoma in penis is a rare disease characterized by verrucous lesions. The traditional methods for verrucous carcinoma resulting in loss of sexual function are not satisfactory. The purpose of this study was to evaluate the safety and effect of topical aminolevulinic acid photodynamic therapy in the treatment of verrucous carcinoma in penis. MATERIALS AND METHODS: In this study, four male patients, average age of (47 ± 7.58) years old, with penile verrucous carcinoma were treated with topical aminolevulinic acid photodynamic therapy (ALA-PDT) combined with curettage...
September 8, 2018: Photodiagnosis and Photodynamic Therapy
Gyung-Min Kim, Bo-Ra Kim, Eun-Song Lee, Elbert de Josselin de Jong, Baek-Il Kim
INTRODUCTION: This study evaluated the fluorescence of orthodontic adhesives using quantitative light-induced fluorescence-digital (QLF-D) images, and compared the fluorescence color difference between adhesive and the adjacent tooth with that under white-light illumination in specimens with various residual thicknesses. METHODS: Transbond™ XT, Blugloo™, and Enlight were used to prepare (1) adhesive discs and (2) adhesive specimens attached to extracted human tooth, which was ground to thicknesses ranging from 800 to 20 μm...
September 1, 2018: Photodiagnosis and Photodynamic Therapy
Anna Thereza Peroba Rezende Ramos, Lauriê Garcia Belizário, Keren Cristina Fagundes Jordão-Basso, André Luis Shinohara, Milton Carlos Kuga
INTRODUCTION: Photodynamic therapy (PDT) can be employed prosthetic space decontamination; however, its effects on adhesion of glass-fiber posts cementation systems are still unclear. PURPOSE: The aim of this study was to evaluate the effects of photodynamic therapy (PDT) on the adhesive interface between the dentin and different glass-fiber post cementation systems using a self-adhesive resin cement (RelyX U200) or a glass ionomer cement (Gold Label 1). METHOD: Forty human canine roots were endodontically-treated and prepared for fiber post...
August 30, 2018: Photodiagnosis and Photodynamic Therapy
Yusuke Matoba, Kouji Banno, Iori Kisu, Daisuke Aoki
INTRODUCTION: Several types of photosensitizers such as 5-aminolevulinic acid are progenitors of protoporphyrin IX (PpIX). PpIX accumulates in cancer cells and has photosensitivity. Based on these characteristics, these are used in photodynamic diagnosis (PDD) and photodynamic therapy (PDT). These methods have recently been applied to gynecologic malignant diseases. Here, we review articles on clinical applications of PDD and PDT for these diseases. MATERIALS AND METHODS: A systematic literature search in Pubmed was performed with a combination of keywords to collect the articles...
August 29, 2018: Photodiagnosis and Photodynamic Therapy
Amal Saeed Al-Qahtani, Sahar Asaad AlZain, Eman Mohammed AlHamdan, Huda Ismail Tulbah, Hana Mohammed Al Alsheikh, Mustafa Naseem, Fahim Vohra
The aim of the study was to evaluate the effect of diode laser as a phototherapy on surface treatment of fiber post and its bond strength to resin core build-up material. In this in-vitro study fifty fiber post of 1 mm tip-diameter and 20 mm length were used. The posts were mounted and randomly divided into 5 groups (n = 10) according to different surface treatment methods i.e. Group 1 Control, Group 2 Application of 37% Phosphoric Acid, Group 3 Treated with 40% H2O2, Group 4 Sandblasted with 50 ㎛ aluminium oxide particles and Group 5 treated with diode laser...
August 29, 2018: Photodiagnosis and Photodynamic Therapy
Jésica Yanina Pereyra, Emma Antonia Cuello, Horacio Javier Salavagione, César Alfredo Barbero, Diego Fernando Acevedo, Edith Inés Yslas
The manuscript shows the application of unmodified graphene oxide (GO) as a photothermally susceptible material to trigger antibacterial effects. The synthesis and characterization of unmodified GO easily dispersed in aqueous solutions is also shown. High GO concentrations in the dark and low GO concentrations irradiated with near infrared light (NIR) produced death in nosocomial bacterium (Pseudomonas aeruginosa). It is demonstrated that GO dispersion in the dark produced a dose-dependent increase in the antibacterial action at concentrations up to 120 µg/mL...
August 28, 2018: Photodiagnosis and Photodynamic Therapy
Maíra Terra Garcia, André Henrique Correia Pereira, Antonio Olavo Cardoso Jorge, Juliana Ferreira Strixino, Juliana Campos Junqueira
Photodynamic therapy (PDT) can be used for the control of oral pathogens and different photosensitizers (PS) have been investigated. This study evaluated the efficacy of PDT against Streptococcus mutans biofilms using two second-generation PS derived from chlorin: Photoditazine® (PDZ) and Fotoenticine® (FTC). These PS were compared to methylene blue (MB), a dye with proven antimicrobial activity against S. mutans. Suspensions of S. mutans were cultured in contact with bovine tooth disks for biofilm formation...
August 26, 2018: Photodiagnosis and Photodynamic Therapy
Farzaneh Ahrari, Mostafa Shahabi, Reza Fekrazad, Neda Eslami, Fatemeh Mazhari, Kiarash Ghazvini, Niloofar Emrani
This study investigated the efficacy of photodynamic therapy (PDT) using EmunDo as a photosensitizer against Lactobacillus acidophilus. A gallium aluminum arsenide diode laser was used in this experiment (810 nm, CW). Standard suspensions of Lactobacillus acidophilus were divided into six groups by treatment: 1) EmunDo, 2) diode laser (100 mW, 90 seconds), 3) diode laser (300 mW, 30 seconds); 4) EmunDo + diode laser (100 mW, 90 seconds), 5) EmunDo + diode laser (300 mW, 30 seconds), 6) control (no treatment)...
August 25, 2018: Photodiagnosis and Photodynamic Therapy
Khomidkhodza Kholikov, Saidjafarzoda Ilhom, Muhammed Sajjad, Michael E Smith, Jerry D Monroe, Omer San, Ali Oguz Er
Due to their many unique properties, graphene quantum dots (GQDs) have attracted much attention and are a promising material with potential applications in many fields. One application of GQDs is as a photodynamic therapy agent that generates singlet oxygen. In this work, GQDs were grown by focusing nanosecond laser pulses into benzene and then were later combined with methylene blue (MB) and used to eradicate the Gram-negative bacteria, Escherichia coli, and Gram-positive bacteria, Micrococcus luteus. Theoretical calculation of pressure evolution was calculated using the standard finite difference method...
August 22, 2018: Photodiagnosis and Photodynamic Therapy
Abdollah Ghorbanzadeh, Reza Fekrazad, Abbas Bahador, Roya Ayar, Siavash Tabatabai, Sohrab Asefi
BACKGROUND: Complete elimination of bacteria and their by-products from the root canal system is very difficult with current techniques. The purpose of this study was to compare the antibacterial efficacy of different disinfection protocols against Enterococcus faecalis (E. faecalis) biofilms. METHODS: Seventy-six extracted single-rooted human teeth were selected. Root canal preparation was done by proTaper rotary instruments. The smear layer was removed by 17% EDTA, followed by 5...
August 18, 2018: Photodiagnosis and Photodynamic Therapy
Hyejin Kim, Sung Won Kim, Kwang Hyuk Seok, Chi Woo Hwang, Jin-Chul Ahn, Jun-O Jin, Hyun Wook Kang
BACKGROUND: Hypericin (HYP) extracted from St. John's wort ( Hypericum perforatum L.) is a natural photosensitizer in clinical photodynamic therapy (PDT). The PDT is one of the powerful methods for cancer treatments because of its excellent tumoritropic characteristics and photosensitizing properties. However, limited reports on the efficacy of PDT on the anaplastic thyroid cancer (ATC) have been published. Especially HYP-associated PDT has not been investigated in vitro and in vivo. In this study, we evaluated the effect of HYP for PDT against FRO ATC cells...
August 14, 2018: Photodiagnosis and Photodynamic Therapy
Lili Fan, Rui Yin, Ting Lan, Michael R Hamblin
BACKGROUND: Rosacea is a common chronic cutaneous disorder which is characterized by flushing, erythema, papulopustules and telangiectasia. The pathogenesis of the disease is still unknown. A multifaceted approach is necessary to control the disease because of its tendency to relapse. New more effective treatment options are desirable to achieve a complete remission. Aminolevulinic acid-photodynamic therapy (ALA-PDT) is a well-established treatment for non-melanoma skin cancer and precancerous lesions...
August 14, 2018: Photodiagnosis and Photodynamic Therapy
Rafael Francisco Lia Mondelli, Cristiane Machado de Almeida, Fabio Antonio Piola Rizzante, Ana Flavia Sanches Borges, Sérgio Kiyoshi Ishikiriama, Juliana Fraga Soares Bombonatti
BACKGROUND: Use of hybrid-light (HL) during in-office teeth bleaching can provide faster and reliable results after a single bleaching session, especially if associated with previous acid etching. The present in vivo, interventional, split-mouth, triple-blinded and randomized study evaluated the efficiency of a HL, with and without prior enamel acid etching, assessing the gel application time, degree of color change, sensitivity and treatment stability up to 12 months. METHODS: Thirty-four patients were selected and randomly divided into four groups...
August 14, 2018: Photodiagnosis and Photodynamic Therapy
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