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Photodiagnosis and Photodynamic Therapy

F Tavakkoli, M Zahedifar, E Sadeghi
LaF3: Ag nanoparticles (NPs) were synthesized by the co-precipitation method. The produced NPs were characterized by X-ray diffraction (XRD) pattern, scanning electron microscope (SEM), dynamic light scattering (DLS) and Fourier transform infrared spectroscopy (FTIR). The emission spectrum of LaF3:Ag NPs is mostly overlapped with the absorption band of protoporphyrin IX (PpIX) and their conjugation was confirmed by studying fluorescence resonance energy transfer (FRET) from LaF3:Ag donor to protoporphyrin IX acceptor...
January 10, 2018: Photodiagnosis and Photodynamic Therapy
Martha Simões Ribeiro, Ronaldo Gomes Gargano, Carolina Dos Anjos, Fabio Celidonio Pogliani, Fábio Parra Sellera, Caetano Padial Sabino
No abstract text is available yet for this article.
January 9, 2018: Photodiagnosis and Photodynamic Therapy
Jingjing Cai, Qiuping Zheng, Huifang Huang, Buhong Li
OBJECTIVES: The purpose of this study was to investigate the effects of 5-aminolaevulinic acid mediated photodynamic therapy (ALA-PDT) on the survival activity and apoptosis of human melanoma cell line A375 and non-melanoma skin carcinoma cell line A431 cells. The mechanism for cellular apoptosis was explored. METHODS: The cell survival activity was determined by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and the proportion of apoptotic cells was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining...
January 5, 2018: Photodiagnosis and Photodynamic Therapy
M J Suárez Valladares, J Vega, M A Rodríguez Prieto
BACKGROUND: Surgery is the treatment of choice in basal cell carcinoma (BCC), but new less invasive techniques are in development as photodynamic therapy. The main problem of this technique is the limited penetration. The use of an intralesional photosensitizer plus an irradiation with a 630 nm laser increased this penetration. OBJETIVES: To compare the effectiveness in treatment of BCC between surgery and intralesional photodynamic therapy (I-PDT). To identify the clearance rate differences between intralesional or external irradiation in I-PTD group...
January 5, 2018: Photodiagnosis and Photodynamic Therapy
Ripon Sarkar, Kabita Chaterjee, Durbadal Ojha, Bijurica Chakraborty, Sanghamitra Sengupta, Debprasad Chattopadhyay, Chirasree RoyChaudhuri, Ananya Barui
Metabolic alterations of oral epithelial cells under oxidative stress are important signatures for early diagnosis of oral cancer. Amongst different metabolic alterations, non-invasive photo-diagnostic methods have been extensively used for determining cellular heme metabolism and accumulation of protoporphyrin IX (PpIX) under administration of suitable photosensitizer. In this study, we report these metabolic alterations by direct analysis of oral exfoliated cells obtained from individuals with prolonged smoking habit without the exogenous administration of any photosensitizer...
January 4, 2018: Photodiagnosis and Photodynamic Therapy
Tatiana Moura Branco, Nádia Castanho Valério, Vânia Isabel Rodrigues Jesus, Cristina Jesus Dias, Maria G P M S Neves, Maria A F Faustino, Adelaide Almeida
In this study, the effect of antimicrobial photodynamic therapy (aPDT) and aPDT combined with antibiotics to inactivate Staphylococcus aureus in vitro and ex vivo was compared. The tetracationic porphyrin 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin tetra-iodide (Tetra-Py+-Me) was used to inactivate S. aureus in phosphate buffer solution (PBS) (in vitro) and in pork skin artificially contaminated with S. aureus (ex vivo). The results showed an efficient reduction of 8 log in PBS, after 180 min of irradiation under white light at 4...
January 4, 2018: Photodiagnosis and Photodynamic Therapy
Yiru Gao, Bingjie Mai, Ao Wang, Min Li, Xiaobing Wang, Kun Zhang, Quanhong Liu, Shaohua Wei, Pan Wang
BACKGROUND: Bacterial infection is a common clinical problem. Community-associated Staphylococcus aureus (S. aureus) infections can cause extensive tissue damage and necrosis. Photodynamic antimicrobial chemotherapy (PACT) has recently attracted attention as a feasible alternative to bacterial therapy. Octa-cationic zinc phthalocyanines are newly identified photosensitizers derived from phthalocyanines bearing 1, 2-ethanediamine groups and quaternized derivatives with different numbers of positive charges (ZnPcn+, n = 4 or 8)...
January 4, 2018: Photodiagnosis and Photodynamic Therapy
Georgios Kareliotis, Sofia Liossi, Mersini Makropoulou
BACKGROUND: In photodynamic therapy (PDT) oxygen plays vital role in killing tumor cells and therefore its dosimetry is being thoroughly studied. METHODS: Light distribution into tissue is modelled for radiation-induced fibrosarcoma (RIF) and nodular basal cell carcinoma (nBCC), in order to study the influence of blood flow on singlet oxygen concentration effectively leading to cell death ([1O2]rx) on PDT, within this light distribution. This is achieved through initial oxygen supply rate (g0) and initial molecular oxygen concentration ([3O2]0) calculations...
December 29, 2017: Photodiagnosis and Photodynamic Therapy
Vanessa Nesi-Reis, Daniele Stéfanie Sara Lopes Lera-Nonose, Jully Oyama, Marielle Priscila Paula Silva-Lalucci, Izabel Galhardo Demarchi, Sandra Mara Alessi Aristides, Jorge Juarez Vieira Teixeira, Thaís Gomes Verzignassi Silveira, Maria Valdrinez Campana Lonardoni
OBJECTIVE: We researched articles that used photodynamic therapy (PDT) in skin wound healing in humans. METHODS: The systematic review was conducted throughout scientific articles that investigated the action of PDT on wound healing in humans, published from July 2005 to March 2017, in the data bases PubMed and LILACS. RESULTS: The main types of wound described in selected articles in this review were chronic ulcer, non-melanoma skin cancer...
December 28, 2017: Photodiagnosis and Photodynamic Therapy
Zhang Shu, Yang Lifeng, Yu Ruichao
BACKGROUND: There are several options for BCC treatment. But sometimes, even Mohs surgery isn't desirable because of predicted aggressive surgery. Treatment of recurrent basal cell carcinoma can be a challenge for dermatologists. METHODS: We describe a case of a man with an invasive recurrent basal cell carcinoma on his face. The tumor was difficult to be removed completely by excision. Thus one-time photodynamic therapy was performed in the defect during surgery...
December 27, 2017: Photodiagnosis and Photodynamic Therapy
Brezániová Ingrid, Záruba Kamil, Králová Jarmila, Sinica Alla, Adámková Hana, Ulbrich Pavel, Poučková Pavla, Hrubý Martin, Štěpánek Petr, Král Vladimír
BACKGROUND: Drug targeting using functionalized nanoparticles to advance their transport to the dedicated site became a new standard in novel anticancer methods Anticancer photodynamic therapy also takes benefit from using nanoparticles by means of increasing targeting efficiency and decreased side effect. With this in mind, the silica-based nanoparticles, as drug delivery systems for the second-generation photosensitizer 5,10,15,20-tetrakis(m-hydroxyphenyl) chlorin (temoporfin) were development...
December 27, 2017: Photodiagnosis and Photodynamic Therapy
Vieri Grandi, Stefano Bacci, Alessandro Corsi, Maurizio Sessa, Elisa Puliti, Nicoletta Murciano, Francesca Scavone, Pietro Cappugi, Nicola Pimpinelli
A cohort of 19 patients affected by chronic venous ulcers was recruited from our centre. A 4-mm punch biopsy from wound bed was taken before application of ALA 20% gel and repeated one hour after the first PDT irradiation. We observed a significant and progressive reduction of wounds mean volumes right after three ALA-PDT sessions (once per week; 4479.9 +/- 345.5 mm3 vs 34599 +/- 190.3 mm3, p < 0.01). On immunofluorescence staining from biopsy specimens, we observed a change in all tested stains of post treatment specimens compared to pre-treatment ones...
December 22, 2017: Photodiagnosis and Photodynamic Therapy
V Nesi-Reis, T R Navasconi, D S S L Lera-Nosone, E L Oliveira, P M Barbosa, W Caetano, T G V Silveira, S M A Aristides, N Hioka, M V C Lonardoni
This study investigated the activity of photosensitive phthalocyanines on promastigotes and amastigotes of Leishmania (L.) amazonensis. Aluminum phthalocyanine chloride (AlPcCl), Aluminum phthalocyanine hydroxide (AlPcOH) and zinc phthalocyanine (PcZn) were tested in the presence (matte red LED, potency of 2.5-2.3 μW for 30 minutes) and absence of light against L. amazonensis promastigotes and the parasite viability was evaluated after 24, 48 and 72 h. The amastigote forms were treated with AlPcCl and AlPcOH, following the same lighting protocols described for the promastigote forms, being evaluated after 24 h...
December 21, 2017: Photodiagnosis and Photodynamic Therapy
Thalita Santos Dantas Araújo, Paôlla Layanna Fernandes Rodrigues, Mariana Sousa Santos, Janeide Muritiba de Oliveira, Luciano Pereira Rosa, Vanderlei Salvador Bagnato, Kate Cristina Blanco, Francine Cristina da Silva
Photodynamic Therapy (PDT) is a promising alternative for the treatment of infectious bone lesions in the oral cavity. The objective of this study was to evaluate the antimicrobial effectiveness of PDT using blue LED associated with curcumin in methicillin-resistant Staphylococcus aureus biofilms (MRSA) in bovine bone cavities by fluorescence spectroscopy. Standardized suspensions of MRSA culture were inoculated into bone lesions to form biofilm. Forty bone species were distributed in three distinct groups: L-C- (control); L + C- (LED for 5 min...
December 20, 2017: Photodiagnosis and Photodynamic Therapy
Peiru Wang, Linglin Zhang, Guolong Zhang, Zhongxia Zhou, Haiyan Zhang, Zijun Zhao, Lei Shi Xiuli Wang
Giant cutaneous squamous cell carcinoma (cSCC) in elderly people is difficult to treat. Herein, we report a case of 96-year-old male who was diagnosed to have giant facial invasive SCC (4cm*4.5cm*2 cm). He was successfully treated with plum-blossom needle assisted photodynamic therapy (PDT) sequential with imiquimod. The patient achieved complete remission after 9 sessions of PDT and 3 months of imiquimod but developed residual vitiligo-like hypopigmentation. There was no recurrence at 18 months of follow-up...
December 19, 2017: Photodiagnosis and Photodynamic Therapy
Ting Lan, Yongzhen Zou, Michael R Hamblin, Rui Yin
BACKGROUND: Vulvar lichen sclerosus et atrophicus (VLSA) is a chronic inflammatory skin disease of unknown etiology that mainly affects postmenopausal and perimenopausal women. The primary clinical symptoms of VLSA are itching, burning pain, and dyspareunia that can results in decreased quality of life. Existing therapies including topical corticosteroid ointment, topical calcineurin inhibitors, estrogens, are not very effective for treatment of VLSA. OBJECTIVE: To evaluate the effectiveness and safety of 5-aminolevulinic acid mediated photodynamic therapy (ALA-PDT) in the treatment of VLSA...
December 16, 2017: Photodiagnosis and Photodynamic Therapy
Lívia Helena Moreira, José Carlos Pereira de Souza, Carlos José de Lima, Miguel Angel Castillo Salgado, Adriana Barrinha Fernandes, Dora Inés Kozusny Andreani, Antonio Balbin Villaverde, Renato Amaro Zângaro
BACKGROUND: Bovine mastitis is a disease that causes a severe drawback in dairy production. Conventional treatments with antibiotic could leave antibiotic residues in the milk. The aim of this study was to evaluate the effect of photodynamic therapy in the treatment of bovine subclinical mastitis to develop an in vivo therapeutic protocol that could be used in routine farm practice, favoring the early return to production. METHODS: Forty cows with subclinical mastitis (n = 40) were divided into 4 groups (control, photodynamic therapy - PDT, light irradiation - LED, and photosensitizer - PS)...
December 16, 2017: Photodiagnosis and Photodynamic Therapy
Bishakh Rout, Chi-Hsien Liu, Wei-Chi Wu
BACKGROUND: Photodynamic therapy has been studied by many studies as a method for inactivating bacterial growth. Workers have used planktonic bacterial as well as biofilm bacterial cultures to evaluate the potential of photodynamic therapy in inactivating bacteria. However, almost all the studies use a photosensitiser in aqueous solution, which could be detrimental to the efficiency of photodynamic therapy. METHODS: In this study, the photodynamic killing effect of toluidine blue O (TBO) has been investigated on Staphylococcal biofilms in -vitro...
December 13, 2017: Photodiagnosis and Photodynamic Therapy
Fabiana Sodré de Oliveira, Thiago Cruvinel, Daniela Alejandra Cusicanqui Méndez, Evandro José Dionísio, Daniel Rios, Maria Aparecida Andrade Moreira Machado
BACKGROUND: The aPDT could enhance the prevention of dental caries lesions in pits and fissures of partially erupted molars, by killing microorganisms from complex dental biofilms. This pilot study aimed to evaluate the effect of the Antimicrobial Photodynamic Therapy (aPDT) on the viability of specific microorganism groups of dental microcosm biofilms from occlusal surfaces of first permanent molars in eruption. METHODS: Dental microcosm biofilms grown on bovine enamel blocks, from dental plaque collected on occlusal surfaces of a partially erupted lower right first permanent molar, with McBain medium plus 1% sucrose in anaerobic condition at 37°C for 72h...
December 9, 2017: Photodiagnosis and Photodynamic Therapy
Saygo Tomo, Luciana Estevam Simonato
No abstract text is available yet for this article.
December 6, 2017: Photodiagnosis and Photodynamic Therapy
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