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Photodiagnosis and Photodynamic Therapy

Waseem Jerjes, Zaid Hamdoon, Colin Hopper
INTRODUCTION: Photodynamic therapy (PDT) is a relatively new method of treating various kinds of pathologies. In this retrospective study, a total of 148 patients with basal cell carcinoma (BCC) were treated with surface illumination methyl aminolevulinate - photodynamic therapy (MAL-PDT) or meta-tetrahydroxyphenylchlorin (mTHPC-PDT). Comparisons with the clinical features, rate of recurrence and overall outcome were made. MATERIALS AND METHODS: Surface illumination PDT was offered under local or general anaesthesia...
April 22, 2017: Photodiagnosis and Photodynamic Therapy
Samira Gharesi, Maryam Pourhajibagher, Nasim Chiniforush, Reza Raoofian, Mehrdad Hashemi, Sima Shahabi, Abbas Bahador
BACKGROUND: Periodontal diseases refer to inflammation of the gingiva, induction of apoptosis in human gingival fibroblast cells, destruction of the surrounding tissues, and early bone loss resulting in infections due to the pathogenic activity of the microorganisms and the host immune inflammatory responses. Recent investigations have suggested that antimicrobial photodynamic therapy (aPDT) can be an adjunct treatment therapy for periodontal infections. AIM: To prove the lack of side effects of PDT on periodontal tissues, we investigated the expression of BAX and BCL-2 genes that are involved in apoptosis after the PDT on human gingival fibroblast (HGF) cells...
April 21, 2017: Photodiagnosis and Photodynamic Therapy
Kumi Ogihara, Hajime Isomoto, Hiroki Kurumi, Tsutomu Kanda, Mikiko Hashisako, Kazuhiro Tabata, Hiroyuki Ishii, Ken Ohnita, Naoyuki Yamaguchi, Yuko Akazawa, Kayoko Matsushima, Fuminao Takeshima, Masaki Kunizaki, Shigekazu Hidaka, Atsushi Nanashima, Junya Fukuoka, Takeshi Nagayasu, Kazuhiko Nakao
BACKGROUND: 5-Aminolevulinic acid is a precursor of photosensitizing protoporphyrin IX and has been applied for photodynamic diagnosis of brain and bladder tumors with few side effects. Although most upper gastrointestinal tumors can be detected during photodynamic diagnosis, some tumors containing signet-ring cells cannot be visualized. Here, we aimed to assess whether proteins involved in the absorbance, activation, and turnover of protoporphyrin IX altered the fluorescence signal in gastric cancer...
April 14, 2017: Photodiagnosis and Photodynamic Therapy
Cintia R Lima Leal, Letícia H Alvarenga, Tamires Oliveira-Silva, Ilka T Kato, Bianca Godoy-Miranda, Sandra K Bussadori, Martha S Ribeiro, Renato A Prates
BACKGROUND: Dental caries are multifactorial disease and progressively produces tooth destruction as result from bacterial colonization of enamel surface, especially Streptococcus mutans. The objective of this work was to investigate the role of glucose in antimicrobial photodynamic therapy (aPDT) on S. mutans. METHODS: S. mutans ATCC 25175 were cultured on microaerophilia at 37°C for 48h, and we tested aPDT in the presence of 50mM glucose. Bacterial suspension was used to investigate aPDT with 100μM methylene blue (MB) under LED emitting radiation at ʎ=660nm and parameters as following (P=473 mW; I=166...
April 13, 2017: Photodiagnosis and Photodynamic Therapy
Reza Fekrazad, Farzaneh Khoei, Abbas Bahador, Neda Hakimiha
BACKGROUND: Periodontal pathogens are the main factors responsible for periodontal diseases and considering the limitations of conventional mechanical debridement, new treatment approaches are under investigation. This study was designed to evaluate and compare the antibacterial effects of two different systems of photodynamic and photothermal therapy on Aggregatibacter actinomycetemcomitans as the main pathogen involved in aggressive Periodontitis. METHODS: Cultures of Aggregatibacter actinomycetemcomitans were exposed to 662nm laser in presence of Radachlorin(®) photosensitizer (photodynamic group) or 810nm laser in presence of EmunDo(®) photosensitizer (photothermal group), then bacterial suspension of each well in the study groups were diluted and subcultured on the surface of Muller-Hinton agar plates...
April 13, 2017: Photodiagnosis and Photodynamic Therapy
Hamid Ali, Safdar Ali, Maryam Mazhar, Amjad Ali, Azra Jahan, Abid Ali
Hepatitis is one of the most common life threatening diseases. The diagnosis is mainly based on biochemical analysis such as liver function test. However, histopathological evaluation of liver serves far better for more accurate final diagnosis. The goal of our study was to evaluate the eosin fluorescence pattern in CCl4-induced liver injury model compared with normal and different treatment groups. For this purpose, liver tissues were stained with H/E and examined under bright field microscope but the fluorescence microscopy of H/E stained slides provided an interesting fluorescence pattern and was quite helpful in identifying different structures...
April 8, 2017: Photodiagnosis and Photodynamic Therapy
Gustavo Sivieri-Araujo, Índia Olinta de Azevedo Queiroz, Renan Dal Fabbro, Fernanda Esteves, Luciano Tavares Angelo Cintra, Paulo Carvalho Tobias Duarte, Vanderlei Salvador Bagnato, Sandra Helena Penha de Oliveira, João Eduardo Gomes-Filho
BACKGROUND: The antimicrobial photodynamic therapy (aPDT) inactivates the target cell via reactions among the photosensitizer (PS), Laser or Led and O2. The aim of this study was to evaluate the tissue reaction and cytokine production promoted by aPDT with curcumin photosensitizer. METHODS: Polyethylene tubes containing saline solution (control), 5% sodium hypochlorite (NaOCl) and aPDT with curcumin PS 500mg/L, were implanted into dorsal connective tissue of Wistar rats...
April 4, 2017: Photodiagnosis and Photodynamic Therapy
Lihua Li, Leila H Rashidi, Mengyu Yao, Lun Ma, Lingling Chen, Junying Zhang, Yu Zhang, Wei Chen
Photodynamic therapy (PDT) and photothermal therapy (PTT) have been emerging as attractive and promising methods for tumor treatment in clinical approaches. CuS nanoparticles are effective and cost-effective agents for PTT. Recently, it was observed that CuS nanoparticles are also excellence candidates for PDT. However, the mechanisms for CuS nanoparticles as PDT agents have never been discussed. The goal here is to explore the killing mechanisms of CuS nanoparticles as PTT and PDT agents. CuS nanoparticles were synthesized by a simple wet chemistry method by coating with amphiphilic polymer and examined for their therapeutic potential on lung adenocarcinoma cell line SPC-A-1 in vitro and in vivo using a murine cancer model...
April 4, 2017: Photodiagnosis and Photodynamic Therapy
Theresa N Canavan, Salma Faghri de la Feld, Conway Huang, Naveed Sami
Treating skin cancers and extensive actinic keratosis in patients with bullous pemphigoid (BP) can be challenging. Treatment options pose unique risks in these patients as surgical wounds can have delayed wound healing and photodynamic therapy (PDT) may exacerbate their blistering disease. We report the successful use of PDT to treat actinic keratosis and skin cancers in two patients with BP, both of whom had excellent response to PDT and tolerated treatment without any bullous disease flares. Carefully selected patients with skin cancers and stable, well controlled BP can be safely considered for treatment using PDT...
March 31, 2017: Photodiagnosis and Photodynamic Therapy
Matus Misuth, Denis Horvath, Pavol Miskovsky, Veronika Huntosova
BACKGROUND: Gliomas belong to the most infiltrative types of tumors. Photodynamic therapy (PDT) can be applied to regulate glioma cell proliferation. The inhibitors of PKCs are very promising drugs that can mediate glioma cells apoptosis in PDT. Hypericin is one of PKCs regulators, and thanks to its physicochemical properties it can be used in PDT. Rottlerin is also considered to be the PKCδ inhibitor. Its implementation in PDT may significantly influence glioma cells response to PDT...
March 31, 2017: Photodiagnosis and Photodynamic Therapy
Edwin X Goh, Kai Soo Tan, Yiong Huak Chan, Lum Peng Lim
BACKGROUND: The study aims to compare the effects of adjunctive photodynamic therapy (PDT) with scaling and root debridement alone on periodontal parameters and inflammatory cytokines in residual pockets of patients undergoing maintenance therapy. METHODS: 27 subjects, each with at least 2 residual pockets ≥5mm, were recruited for this randomized, split-mouth controlled trial, providing total of 72 sites. Probing pocket depth (PPD), recession, clinical attachment loss (CAL), plaque and bleeding on probing of all sites were examined at baseline, 3 and 6 months...
March 30, 2017: Photodiagnosis and Photodynamic Therapy
Vitoria Helena Maciel, Wagner Rafael Correr, Cristina Kurachi, Vanderlei Salvador Bagnato, Cacilda da Silva Souza
BACKGROUND: Fast and non-invasive analytical methods, as fluorescence spectroscopy, have potential applications to detect modifications of biochemical and morphologic properties of malignant tissues. In this study, we propose to analyze the fluorescence spectra using k-Nearest Neighbours algorithm (k-NN) and ratio of the fluorescence intensity (FI) to differentiate skin disorders of distinctive etiologies and morphologies. MATERIALS AND METHODS: Laser-induced autofluorescence spectra upon excitation at 408nm were collected from basal cell carcinoma (BCC) subtypes (n=45/212 spectra), psoriasis (PS) (n=37/193 spectra) and Bowen's disease (BD) (n=04/19 spectra) lesions and respective normal skin at sun-exposed (EXP) and non-exposed (NEXP) sites of the same patient...
March 28, 2017: Photodiagnosis and Photodynamic Therapy
Chan-Hee Kim, Eun-Song Lee, Si-Mook Kang, Elbert de Josselin de Jong, Baek-Il Kim
BACKGROUND: The aim of this study was to determine the effect of titanium dioxide (TiO2) photocatalysis induced by the application of clinically acceptable visible light at 405nm on the growth of Streptococcus mutans biofilms. METHODS: S. mutans biofilms were grown on a hydroxyapatite (HA) disk and deposited in a rutile-type TiO2 solution at a concentration of 0.1mg/mL. TiO2 photocatalysis was measured for exposure to visible light (405 nm) and ultraviolet (UV) light (254 nm) produced by light-emitting diodes for 10, 20, 30, and 40 minutes...
March 28, 2017: Photodiagnosis and Photodynamic Therapy
Reza Fekrazad, Bahman Seraj, Nasim Chiniforush, Mehrak Rokouei, Niloofar Mousavi, Sara Ghadimi
BACKGROUND: Antimicrobial photodynamic therapy (aPDT) is a novel technique for reduction of pathogenic microorganisms in dentistry. The aim of this study was to evaluate the effects of aPDT on Streptococcus mutans reduction in children with severe early childhood caries. METHODS: Twenty-two children with severe early childhood caries aged 3 to 6 years were treated with toluoidine blue O (TBO) for 1 minute and irradiated by a Light Emitting Diode (LED; FotoSan, CMS Dental, Denmark) with the exposure time of 150seconds...
March 27, 2017: Photodiagnosis and Photodynamic Therapy
Monalisa Jacob Guiselini, Alessandro Melo Deana, Daniela de Fátima Teixeira da Silva, Nelson Hideyoshi Koshoji, Raquel Agnelli Mesquita-Ferrari, Katia Llanos do Vale, Marcelo Betti Mascaro, Simone Aleksandra de Moraes, Sandra Kalil Bussadori, Kristianne Porta Santos Fernandes
BACKGROUND: Bone tissue anatomy, density and porosity vary among subjects in different phases of life and even within areas of a single specimen. The optical characteristics of changes in bone tissue are analyzed based on these properties. Photobiomodulation has been used to improve bone healing after surgery or fractures. Thus, knowledge on light propagation is of considerable importance to the obtainment of successful clinical outcomes. OBJECTIVE: This study determines light penetration and distribution in human maxillary and mandibular bones in three different regions (anterior, middle, and posterior)...
March 27, 2017: Photodiagnosis and Photodynamic Therapy
Wanessa C M A Melo, Mariana Bastos Dos Santos, Beatriz de Carvalho Marques, Luis Octávio Regasini, Maria José Soares Mendes Giannini, Ana Marisa Fusco Almeida
No abstract text is available yet for this article.
March 27, 2017: Photodiagnosis and Photodynamic Therapy
Ning Zhao, Lei Liu
With the wide range of applications, laser pointer used as toys by children becoming a major public safety problem worldwide. Here we present a long term followup of a ten-year-old boy retina injured patient who suffered from green light laser pointer. Retina injured patients caused by green light laser pointer were traditionally treated by steroid. We only gave Lutein treatment prescription according to the wishes of the patient's parents. After an over 12 months followup, the patient's visual acuity and retinal recovery situation, the outcomes are similar as cases with steroid treatment...
March 24, 2017: Photodiagnosis and Photodynamic Therapy
Zeyad H Al-Sowygh
No abstract text is available yet for this article.
March 24, 2017: Photodiagnosis and Photodynamic Therapy
Sávio M L Gontijo, Renata C Felizali, Pedro P G Guimarães, Robson A S Santos, Rubén D Sinisterra, Maria E Cortés, Patrícia V Araújo
BACKGROUND: Photodynamic therapy (PDT) is an antitumour treatment that employs the combination of a photosensitive compound, oxygen and visible light. To improve the antitumour activity of PDT, the present study used the strategy of combining PDT with erlotinib (ERL), a drug frequently used in the treatment of epidermoid carcinoma. METHODS: An MTT cell viability assay was used to evaluate the cytotoxicity of PDT combined with ERL on A431 epidermoid carcinoma cells in vitro...
March 23, 2017: Photodiagnosis and Photodynamic Therapy
Jiang Tuo, Qianqian Wang, Ye Liu, Ying Ma, Li Ma, Jiayi Ying, Chengfeng Zhang, Leihong Xiang
BACKGROUND: 5-Aminolevulinic acid mediated -photodynamic therapy (ALA-PDT) is known to be effective in treating acne vulgaris and other sebaceous gland-related diseases. However, thetherapeutic mechanisms of ALA-PDT still remain undetermined. In this study, we aimed to investigate theeffects and mechanisms of ALA-PDTon the cell growth and lipogenesis of human SZ95 sebocytes. MATERIAL AND METHODS: Human SZ95 sebocytes were treated with different concentration of ALA-PDT...
March 19, 2017: Photodiagnosis and Photodynamic Therapy
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