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Photodiagnosis and Photodynamic Therapy

Jordon Sandland, Nela Malatesti, Ross Boyle
This review summarises recent research into combining the photosensitizing properties of porphyrins with imaging techniques such as PET and NIR fluorescence for so called "theranostic" applications, which combine biomedical imaging and therapeutic potential into a single administered substance. The photophysical mechanisms of both the therapeutic and diagnostic properties of porphyrins are discussed, as well as key characteristics that are required in order to deliver the most effective treatment.
July 12, 2018: Photodiagnosis and Photodynamic Therapy
Yang Tan, Qionghui Cheng, Hang Yang, Hongdong Li, Nanpeng Gong, Ding Liu, Jinjin Wu, Xia Lei
AIM: To investigate the effects of ALA-PDT on biofilm structure, virulence factor secretion, and quorum sensing (QS) in Pseudomonas aeruginosa. MATERIALS AND METHODS: We used confocal laser scanning microscopy (CLSM), an XTT assay, scanning electron microscopy (SEM), a virulence factor assay and qRT-PCR in this study. RESULTS: The XTT assay showed that ALA-PDT significantly inhibited the growth of planktonic P. aeruginosa. CLSM and SEM showed that ALA-PDT destroyed both bacterial and biofilm structures...
July 10, 2018: Photodiagnosis and Photodynamic Therapy
Hasan Hoseinpour Jajarm, Reza Asadi, Erfan Bardideh, Hooman Shafaee, Yeganeh Khazaei, Maryam Emadzadeh
BACKGROUND: Oral lichen planus (OLP) is a chronic immune-mediated disorder that inflicts oral mucosa in 0.5-2% of the population. Surgery, photodynamic therapy, laser therapy and most commonly pharmacological therapy (like corticosteroids) has been used for treating OLP. New phototherapy approaches have been shown to have positive effects on treating some oral lesions and the aim of our study was to assess the effects of different phototherapy treatments on OLP. METHODS: We conducted a comprehensive electronic search using the determined search strategy in MEDLINE, EMBASE and CENTRAL electronic databases...
July 10, 2018: Photodiagnosis and Photodynamic Therapy
Takahiro Fujishiro, Naosuke Nonoguchi, Marat Pavliukov, Naoki Ohmura, Yangtae Park, Yoshinaga Kajimoto, Toshihisa Ishikawa, Ichiro Nakano, Toshihiko Kuroiwa
BACKGROUND: Glioblastoma (GBM) is a highly malignant lethal brain cancer. Accumulated evidence suggests that elevated resistance of GBM to both chemo- and radio-therapy is, at least in part, due to the presence of a small population of glioma stem cells (GSC). In the present study, we aimed to determine the sensitivity of GSCs to 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT). METHODS: For this purpose, we established GSC-enriched cell cultures (termed glioma stem-like cells or GSLCs) from A172 human GBM cell line...
July 7, 2018: Photodiagnosis and Photodynamic Therapy
Ana Luiza do Rosário Palma, Lucas de Paula Ramos, Nádia Domingues, Graziella Nuernberg Back-Brito, Luciane Dias de Oliveira, Cristiane Aparecida Pereira, Antonio Olavo Cardoso Jorge
The aims of this study (in vitro) was evaluated the effects of photodynamic inactivation (PDI) on single and multi-species biofilms, compounds by Candida albicans and Streptococcus sanguinis. Biofilms were formed, on microplate of 96 wells, by suspensions of C. albicans (ATCC 18804) and S. sanguinis (ATCC 7073) adjusted in 107 cells/mL, followed by incubation of 48 h (with 5% CO2 ). The effects of the photosensitizer erythrosine (ER) at 400 µM for 5 min and green light-emitting diode (LED - 532 ± 10 nm) for 3 min, alone and conjugated, were evaluated...
July 7, 2018: Photodiagnosis and Photodynamic Therapy
Serge Mordon
No abstract text is available yet for this article.
July 4, 2018: Photodiagnosis and Photodynamic Therapy
Zahra Jamali, Mehdi Khoobi, Sedigheh Marjaneh Hejazi, Neda Eivazi, Saeideh Abdolahpour, Fatemeh Imanparast, Hemen Moradi-Sardareh, Maliheh Paknejad
In this study, antibody-conjugated biodegradable polymeric nanoparticles were developed to enhance the photodaynamic efficiency of curcumin (CUR) on glioblastoma tumor cells. Poly (D, L-lactic-co-glycolic acid) nanoparticles (PLGA NPs) were synthesized and stabilized by polyvinyl alcohol (PVA). Poly(ethylene-alt-maleic anhydride) (PEMA) was used to provide carboxyl groups on the surface of NPs. The CUR or FITC (fluorescein isothiocyanate) was encapsulated in PLGA NPs using the nanoprecipitation method. The carboxylic groups on the surface of the PLGA NPs were covalently conjugated to the amino groups of a monoclonal antibody against EGFRvIII (A-EGFRvIII-f)...
June 30, 2018: Photodiagnosis and Photodynamic Therapy
M Ibrahim Khot, Sarah L Perry, Thomas Maisey, Gemma Armstrong, Helen Andrew, Thomas A Hughes, Nikil Kapur, David G Jayne
BACKGROUND: Photodynamic Therapy (PDT) is an attractive modality for treating solid cancers. This study evaluates the efficacy of Hypericin-PDT as a cytotoxic therapy in colorectal cancer (CRC), using 2D cell cultures and 3D multicellular tumour spheroids. METHODS: Spheroids were generated through forced-floating and agitation-based techniques. 2D and spheroid models of HT29 and HCT116 CRC cells were incubated with Hypericin (0-200 nM) for 16 hours. Cultures were irradiated with light (1 J/cm2 ) and cytotoxicity assessed using Propidium Iodide fluorescence...
June 30, 2018: Photodiagnosis and Photodynamic Therapy
Wenjie Liu, Qianqian Wang, Jiang Tuo, Yufeng Chang, Jiayi Ying, Min Jiang, Christos C Zouboulis, Leihong Xiang
BACKGROUND: Topical 5-aminolevulinic acid mediated photodynamic therapy (PDT) is known to be an effective method in treating acne vulgaris and other sebaceous gland-related diseases. The therapeutic mechanisms of ALA-PDT still remain undetermined. In this study, we aimed to investigate the upstream of mammalian target of rapamycin (mTOR) signaling cascade after ALA-PDT on cell growth of human SZ95 sebocytes. MATERIAL AND METHODS: Human SZ95 sebocytes were treated with different concentration of 5-ALA PDT...
June 28, 2018: Photodiagnosis and Photodynamic Therapy
Estefania Baigorria, Eugenia Reynoso, M Gabriela Alvarez, M Elisa Milanesio, Edgardo N Durantini
Silica nanoparticles (SiNPs) embedded with Zn(II) 2,9,16,23-tetrakis(methoxy)phthalocyanine (SiNPZnPcOCH3 ), Zn(II) 2,9,16,23-tetrakis(4-pyridyloxy) phthalocyanine (SiNPZnPcOPy) and Zn(II) 2,9,16,23-tetrakis(t-butyl) phthalocyanine (SiNPZnPctBu) were synthesized in the nonpolar core of AOT/1-butanol/water micelles using triethoxyvinylsilane and 3-aminopropyltriethoxysilane. These SiNPs-Pc presented an average diameter of about 20-25 nm. UV-visible absorption spectra presented the characteristic Soret and Q bands of phthalocyanines embedded into the nanoparticles...
June 28, 2018: Photodiagnosis and Photodynamic Therapy
Alessandra Nara de Souza Rastelli, Hércules Bezerra Dias, Emanuelle Teixeira Carrera, Ana Cláudia Pedroso de Barros, Diego Dantas Lopes Dos Santos, Vitor Hugo Panhóca, Vanderlei Salvador Bagnato
The use of violet LED was recently introduced as a new alternative technique to perform tooth bleaching, associated or not to bleaching agents. This paper shows a tooth bleaching clinical case report performed in a 26-year-old woman, using a violet LED associated to 10% carbamide peroxide (CP). The tooth bleaching protocol was performed in 3 sessions. Fifteen irradiations using a violet light system (BMW, MMoptics, São Carlos, SP, Brazil) were done during 30 seconds (on) and 60 seconds (off) without bleaching gel, and more 5 irradiations associated to 10% CP...
June 28, 2018: Photodiagnosis and Photodynamic Therapy
Vivek Raju, NipunBabu Varukattu, Rejeeth Chandrababu, Sharma Alok, Ponraj Thondhi, Vasanthakumar Alagarsamy, Kannan Soundarapandian
Herein, we posit a biocompatible and pH-switchable integrated nanodelivery of CBP/ICG to the in vitro and in vivo experiments demonstrate that nanoparticles (NPs) have insignificant toxicity and good biocompatibility, and possess excellent tumor targeting efficiency as evidenced by highly efficient tumor ablation under near infrared (NIR) illumination. In addition, we have conjugated folic acid as a targeting ligand for folate receptor-targeted delivery. Particularly, targeted delivery of dual CBP/ICG loaded NPs provide targeted detection and transporting potential to specific receptor-expressing tumors, and then CBP interfering with DNA damage and ICG generates singlet oxygen as well as photothermal heat when irradiated with NIR for simultaneous trimodal PDT/PTT/Chemotherapy...
June 28, 2018: Photodiagnosis and Photodynamic Therapy
Niranga Wijesiri, Zhao Yu, Hong Tang, Peng Zhang
Trichophyton rubrum is one of the most common dermatophytes, which can cause fungal nail and ringworm infections. Infections associated with T. rubrum have become a global phenomenon. Herein, we report the antifungal photodynamic inactivation of T. rubrum (ATCC 28188) using the mesoporous silica-coated silver nanoparticle-based hybrid photosensitizers without involving antifungal drugs. Results show that the hybrid photosensitizers display low cytotoxicity under the experimental conditions where significant killing (~3 orders of magnitude) against T...
June 23, 2018: Photodiagnosis and Photodynamic Therapy
Rinku Singh, Hals Ingrid, Høgset Anders, Grill Valdemar, A Gederaas Odrun
No abstract text is available yet for this article.
June 21, 2018: Photodiagnosis and Photodynamic Therapy
Alireza Ghader, Ali Abbasian Ardakani, Habib Ghaznavi, Ali Shakeri-Zadeh, Soraya Emamgholizadeh Minaei, Salman Mohajer, Mohammad Hosein Majles Ara
BACKGROUND: This study aimed to explore the potential of the Z-scan technique to improve accuracy in identifying SK-BR-3 and MCF-7 breast cancer cell lines. METHODS: Three in vitro samples were prepared for each breast cancer cell line. A closed-aperture Z-scan technique was used to measure the sign and magnitude of the nonlinear refractive index of each sample. Prior to the Z-scan, all samples were fixed with 1 mL of 5% paraformaldehyde. RESULTS: The sign of the nonlinear refractive indices of MCF-7 and SK-BR-3 breast cancer cell lines were negative and positive, respectively...
June 19, 2018: Photodiagnosis and Photodynamic Therapy
Shan-Shan Li, Ling-Lin Zhang, Shu Nie, Ting Lv, Hong-Wei Wang
Acne is a common skin disease in adolescence. It is a chronic inflammatory disease of the pilosebaceous units, which mainly occurs on the face and upper parts of the trunk. Based on severity of the lesions, acne can be mild, moderate or severe. Severe acne is usually featured with a protracted course and residual scars. Photodynamic therapy (PDT) has been demonstrated to be effective in severe acne recently. We report a case of monozygotic twins with severe acne who were successfully treated with PDT.
June 19, 2018: Photodiagnosis and Photodynamic Therapy
V P S Jesus, L Raniero, G M Lemes, T T Bhattacharjee, P C Caetano Júnior, M L Castilho
Breast cancer is the most commonly diagnosed cancer and the second leading cause of death related to cancer among women worldwide. Screening and advancements in treatments have improved survival rate of women suffering from this ailment. Novel therapeutic techniques may further reduce cancer related mortality. One of the several emerging therapeutic options is Photodynamic Therapy (PDT) that uses light activated photosensitizer (PS) inducing cell death by apoptosis and/or necrosis. Nanotechnology has made contribution to improve photosensitizer for PDT, increasing the efficiency of therapy using gold and silver nanoparticles...
June 18, 2018: Photodiagnosis and Photodynamic Therapy
Hee-Eun Kim, Baek-Il Kim
PURPOSE: The aims of this study were to estimate the histological and optical changes of early carious lesions according to the duration of demineralization and to compare the efficacy to detect early carious lesions of a quantitative light-induced fluorescence (QLF) system with a spectrophotometer according to the lesion depth. METHODS: Eighty-four bovine enamel specimens were immersed in demineralizing gel for six distinct days. The severities of lesions were evaluated by lesion depths (Ld) by polarized light microscopy, fluorescence loss (ΔF) using QLF, and brightness (ΔL* ) by spectrophotometry...
June 16, 2018: Photodiagnosis and Photodynamic Therapy
Paul O'Mahoney, Neil Haigh, Kenny Wood, C Tom A Brown, Sally Ibbotson, Ewan Eadie
OBJECTIVES: Implementation of daylight photodynamic therapy (dPDT) is somewhat limited by variable weather conditions. Light sources have been employed to provide artificial dPDT indoors, with low irradiances and longer treatment times. Uniform light distribution across the target area is key to ensuring effective treatment, particularly for large areas. A novel light source is developed with tuneable direction of light emission in order to meet this challenge. METHODS: Wavelength composition of the novel light source is controlled such that the protoporphyrin-IX (PpIX) weighed spectra of both the light source and daylight match...
June 16, 2018: Photodiagnosis and Photodynamic Therapy
Ting Lv, Fei Miao, Min-Feng Wu, Shu Nie, Shan-Shan Li, Xiuli Wang, Hong-Wei Wang
No abstract text is available yet for this article.
June 15, 2018: Photodiagnosis and Photodynamic Therapy
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