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Photodiagnosis and Photodynamic Therapy

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https://www.readbyqxmd.com/read/28811224/hypericin-cytotoxicity-in-tumor-and-non-tumor-cell-lines-a-chemometric-study
#1
Joyce Laura da Silva Gonçalves, Claudia Bernal, Hidetake Imasatoa, Janice Rodrigues Perussi
Hypericin (HY) is an excellent photoactive compound that has been investigated for the photodynamic treatment of cancer as well as for microorganisms inactivation. In this study, chemometric analysis was applied for the first time on photodynamic assays to investigate the cytotoxicity of HY in tumor (HEp-2) and non-tumor (Vero and HUVEC) cell lines. The experimental planning was based on eight assays using the 2(3) full factorial design combining three important variables for PDT: photosensitizer concentrations, incubation time of cells in HY solutions and employed light dose (=590±10nm)...
August 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28811223/influence-and-mechanism-of-5-aminolevulinic-acid-photodynamic-therapy-on-the-metastasis-of-esophageal-carcinoma
#2
Xiaona Zhang, Longmei Cai, Jingcai He, Xiaoyan Li, Libo Li, Xiaohua Chen, Ping Lan
BACKGROUD: 5-Aminolevulinic acid (ALA) mediated photodynamic therapy (PDT) for the treatment of esophageal cancer was more and more popularly used since it was approved for the treatment of advanced esophageal cancer in 1996. It has been reported to influence the tumor growth and metastasis via a variety of signaling pathways, but its mechanism remains to be further studied. This research studied the effects of ALA-PDT on esophageal carcinoma in vitro and in vivo, discovering its molecular regulating mechanism and the way to enhence the PDT effect...
August 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28807774/chlorin-e6-mediated-photodynamic-therapy-promotes-collagen-production-and-suppresses-mmps-expression-via-modulating-ap-1-signaling-in-p-acnes-stimulated-hacat-cells
#3
A-Reum Ryu, Mi-Young Lee
BACKGROUND: Photodynamic therapy (PDT) is a clinically approved therapeutics for cancers and non-neoplastic diseases, based on the use of a photosensitizer activated by a light. The feasibility of PDT depends on several factors, such as PDT dose, photosensitizer efficacy, type of light source, and target tissue irradiated. METHODS: In this study, the second generation photosensitizer chlorin e6 (Ce6) and halogen light were used to investigate their PDT effect on the collagen production and MMPs expression of heat killed P...
August 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28797828/gene-expression-profiling-of-fima-gene-encoding-fimbriae-among-clinical-isolates-of-porphyromonas-gingivalis-in-response-to-photo-activated-disinfection-therapy
#4
Maryam Pourhajibagher, Abbas Bahador
BACKGROUND: The endodontic infection therapy majorly aims to eradicate the microbial pathogens. Photo-activated disinfection (PAD), also known as antimicrobial photodynamic therapy, is an alternative antimicrobial modality used to control the microorganisms causing endodontic infections. Notably, microorganisms may be exposed to sub-lethal doses of PAD (sPAD), influencing microbial virulence. The present study assessed the effects of sPAD on expression profiling of the gene associated with the biofilm formation being the most essential virulence factor in Porphyromonas gingivalis strain cells that survive the photodynamic reatment in vivo...
August 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28780136/pain-during-topical-photodynamic-therapy-comparing-methyl-aminolevulinate-metvix-%C3%A2-to-aminolaevulinic-acid-ameluz-%C3%A2-an-intra-individual-clinical-study
#5
Shiva Yazdanyar, Kian Zarchi, Gregor B E Jemec
BACKGROUND: Actinic keratoses are often treated by photodynamic therapy. However, the main side effects of this treatment is pain during and short after illumination. OBJECTIVES: To evaluate, in an intra-individual study, whether the pain response differ in treatment of actinic keratoses in scalp and forhead, using branded methyl aminolevulinate (MAL) and aminolaevulinic acid (ALA). Materials and methods Patients with mild to moderate actinic keratoses on forehead and scalp were treated with methyl aminolaevulinate (MAL)-PDT and aminolaevulinic acid (ALA)-PDT on two similar areas of forehead and scalp...
August 2, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28754542/evaluation-of-liver-fibrosis-using-raman-spectroscopy-and-infrared-thermography-a-pilot-study
#6
Miguel G Ramírez-Elías, E S Kolosovas-Machuca, David Kershenobich, Carolina Guzmán, Galileo Escobedo, Francisco J González
Liver fibrosis is a pathological process that can escalate to cirrhosis and then liver failure which are major public health concerns that affect hundreds of millions of people in both developed and developing countries. Detection of liver fibrosis during its earlier stages is a matter of great importance which would allow to prevent the development of cirrhosis in patients with chronic liver disease. In this work, Raman spectroscopy and thermography were evaluated to detect early pathological signs of liver fibrosis in rats in which liver fibrosis was induced using carbon tetrachloride...
July 25, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28750754/physiological-considerations-acting-on-triplet-oxygen-for-explicit-dosimetry-in-photodynamic-therapy
#7
Víctor Sánchez, María Paulina Romero, Sebastião Pratavieira, César Costa
The aims of this study were to determine the spatial and temporal theoretical distribution of the concentrations of Protoporphyrin IX, (3)O2 and doses of (1)O2. The type II mechanism and explicit dosimetry in photodynamic therapy were used. Furthermore, the mechanism of respiration and cellular metabolism acting on (3)O2 were taken into account. The dermis was considered as an absorbing and a scattering medium. An analytical solution was used for light diffusion in the skin. The photophysical, photochemical and biological effects caused by PDT with the initial irradiances of 20, 60 and 150mW/cm(2) were studied for a time of exposure of 20min...
July 24, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28750753/photodynamic-therapy-with-high-power-led-mediated-by-erythrosine-eliminates-enterococcus-faecalis-in-planktonic-forms
#8
Alberto Sabin Moura Borba, Sângela Maria da Silva Pereira, Mellyna Cavalcante Mendes Borba, Marco Aurélio Benini Paschoal, Rudys Rodolfo de Jesus Tavarez, Claudia de Castro Rizzi, Meire Coelho Ferreira, Etevaldo Matos Maia Filho
BACKGROUND: The failure of endodontic treatment is linked to the presence of microorganisms, particularly Enterococcus faecalis, in the root canals. This study evaluated the effectiveness of photodynamic therapy (PDT) using erythrosine irradiated by a high-power curing light on a planktonic suspension culture of E. faecalis. METHODS: Bacterial suspensions of E. faecalis were adjusted and then mixed in a 1:1 proportion, in triplicate, in treatment groups by varying the length of irradiation time (120 and 240seconds) and the molarity of the erythrosine (5 and 10μM)...
July 24, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28743589/density-functionalized-ru-ii-no-salen-cl-complex-computational-photodynamics-and-in-vitro-anticancer-facets
#9
Jan Mohammad Mir, N Jain, P S Jaget, R C Maurya
Photodynamic therapy (PDT) is a treatment that uses photosensitizing agents to kill cancer cells. Scientific community has been eager for decades in enduring curiosity to design an efficient PDT drug. Under such purview, the current report deals with the computational photodynamic behavior of ruthenium(II) nitrosyl complex containing N, N'-salicyldehyde-ethylenediimine (SalenH2), the synthesis and X-ray crystallography of which is already known [Ref. 36]. Gaussian 09W software package was employed to carry out the density functional (DFT) studies...
July 22, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28736046/the-optical-imaging-of-tarantula-hair-corneal-injury-one-case-report-and-review-of-the-literature
#10
Yuedong Hu, Yuanyuan Xu
INTRODUCTION: Tarantulas belonging to the Theraphosidae family are more and more popular as family pets. Ocular injuries caused by tarantulas are reported in several articles. We hereby report the first known case of ocular injury caused by a tarantula in China. CASE: A 22-year-old girl was referred to our hospital with one-week history of red and irritated left eye after she grabbed her molting Chilean Rose Tarantula. Her best-corrected visual acuity was 20/20 on both eyes...
July 20, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28733050/the-optical-imaging-of-an-idiopathic-paracentral-acute-middle-maculopathy-chinese-young-man-and-review-of-the-literatures
#11
REVIEW
Yanyan Chen, Yuedong Hu
We report a case of idiopathic paracentral acute middle maculopathy with typical optical imaging and clinical features. A 26-year-old Chinese policeman presented with a 20-day history of paracentral scotoma in the left eye after early wake-up and long-time working in front of computer the day before. He experienced sudden-onset strong flash in his left eye. Paracentral scotoma appeared in his left eye after 6hours of rest. The general history was negative. His best-corrected visual acuity was 20/20 OU. Anterior segment, dilated fundus examination, papillary evaluation and intraocular pressure were normal...
July 18, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28716739/phototoxicity-in-a-laryngeal-cancer-cell-line-enhanced-by-a-targeting-amphiphilic-chlorin-photosensitizer
#12
Milene N O Moritz, Carlos Rossa, Kleber T de Oliveira, Marciana P Uliana, Janice R Perussi
BACKGROUND: Photodynamic therapy (PDT) has been established in several countries as an alternative therapy for the treatment of various malignancies. This therapy involves the incorporation of a photosensitizer (PS) that is activated by visible light and form reactive oxygen species leading to target cell death by apoptosis or necrosis. Previously, our group has demonstrated that CHL-T (semi-synthesized from chlorophyll a and containing a linked solubilizing group TRISMA(®)) presented a pronounced potential to induce death in HeLa cell line after PDT...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28716738/photodynamic-therapy-and-pain-a-systematic-review
#13
Jennifer Maria Ang, Irbaz Bin Riaz, Muhammad Umar Kamal, Gyorgy Paragh, Nathalie C Zeitouni
Photodynamic therapy (PDT) is an effective treatment for actinic keratoses and early skin cancers, and the only office procedure to control field cancerization. Procedure-associated pain limits widespread PDT use and by early termination of treatment can decrease overall therapeutic efficacy. Here we review and assess reported interventions on PDT-associated pain, in order to identify the most promising methods to manage treatment-associated pain and identify focus for future studies. Literature search was performed using MEDLINE, EMBASE, and the Cochrane Library by two independent reviewers to select publications that assessed and compared pain quantitatively during PDT treatment for actinic keratoses, basal cell carcinomas, and/or in situ squamous cell carcinomas...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28684320/focal-choroidal-excavation-and-a-traumatic-macular-hole-secondary-to-accidental-q-switched-nd-yag-laser
#14
Yuanlu Shuai, Xianglei Chen, Wangyi Fang, Jia Li, Weizhong Ge, Songtao Yuan, Qinghuai Liu
Today, the widespread use of laser instruments in various fields has resulted in many accidental retinal injuries. Here we describe a rare clinical case of full-thickness macular hole (MH) and focal choroidal excavation (FCE) caused by a 1064-nm Q-switched Nd:YAG laser. After pars plana vitrectomy and the following 14 months, consecutive optical coherence tomography imagings showed closure of the MH. Visual acuity improved even in the absence of the outer retina and in the presence of FCE. We speculate that different focusing effects of the unexpected Nd:YAG laser which target different levels of retinal tissue generates diverse prognosis...
July 3, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28669793/comparing-clinical-effects-of-photodynamic-therapy-as-a-novel-method-with-topical-corticosteroid-for-treatment-of-oral-lichen-planus
#15
Sedigheh Bakhtiari, Seyyed Masoud Mojahedi, Saranaz Azari-Marhabi, Mahshid Namdari, Zahra Elmi Rankohi
BACKGROUND: Oral lichen planus is an autoimmune disorder with several challenges in treatment. Photodynamic therapy has been proposed as a new treatment option for the disease. AIM: The present study compared the clinical effects of the photodynamic therapy and dexamethasone mouthwash in the treatment of oral lichen planus lesions. MATERIALS AND METHODS: In this randomized clinical trial, 30 patients with oral lichen planus were included.15 patients were treated with 5% methylene blue mediated photodynamic therapy using Fotosan device for 30seconds (630nm wavelength and 7...
June 29, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28669792/preparation-and-characterization-of-bioadhesive-system-containing-hypericin-for-local-photodynamic-therapy
#16
Fernanda Belincanta Borghi-Pangoni, Mariana Volpato Junqueira, Sabrina Barbosa de Souza Ferreira, Larissa Lachi Silva, Bruno Ribeiro Rabello, Lidiane Vizioli de Castro, Mauro Luciano Baesso, Andréa Diniz, Wilker Caetano, Marcos Luciano Bruschi
Hypericin (Hyp) is a natural photoactive pigment utilized in the treatment of different types of cancer and antimicrobial inactivation using photodynamic therapy (PDT). Hyp is poorly soluble in water conducing to problems of administration, getting closeness contact with the site, and availability. Therefore, this study aimed to develop bioadhesive thermoresponsive system containing Hyp for local PDT. I this sense, carbomer 934P, poloxamer 407, and Hyp were used to prepare the thermoresponsive bioadhesive formulations...
June 29, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28666974/application-of-photodynamic-therapy-laser-therapy-and-a-cellulose-membrane-for-calcaneal-pressure-ulcer-treatment-in-a-diabetic-patient-a-case-report
#17
Luciano Pereira Rosa, Francine Cristina da Silva, Regiane Lima Vieira, Beatriz Rocha Tanajura, Alana Gonçalves da Silva Gusmão, Janeide Muritiba de Oliveira, Nathalia Aparecida Campanário Dos Santos, Vanderlei Salvador Bagnato
Diabetes mellitus is a metabolic disorder in which a person has high blood glucose levels due to inadequate insulin production by the pancreas. Wounds in these individuals cannot heal properly over time due to circulatory changes that hinder and stagnate the healing process. We report the case of an 82-year-old female type 2 diabetes mellitus carrier, presenting to clinical-dermatological examination pressure ulcer (PU) in the right calcaneus region. The patient was treated with photodynamic therapy using curcumin and blue light-emitting diodes (LEDs), laser therapy, and the application of a cellulose membrane in order to promote ulcer decontamination by local action, accelerate wound healing, and maintain favorable conditions of asepsis and moisture, respectively...
June 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28666973/ala-pdt-combined-with-antibiotics-for-the-treatment-of-atypical-mycobacterial-skin-infections-outcomes-and-safety
#18
Kedai Sun, Hang Yang, Xianqiong Huang, Nanpeng Gong, QinQin, Weiping Lu, Xia Lei
BACKGROUND: Photodynamic therapy (PDT) has been shown to be a very successful new therapy in clinical practice, and its usefulness as a treatment for bacterial infections has been gradually recognized by researchers, who believe it has very good clinical prospects. Atypical mycobacterial skin infections are a type of rare refractory infection. The aim of this study was to evaluate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with antibiotics for the treatment of atypical mycobacterial skin infections...
June 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28662924/anticancer-effects-elicited-by-combination-of-rubus-extract-with-phthalocyanine-photosensitiser-on-mcf-7-human-breast-cancer-cells
#19
Blassan P George, Heidi Abrahamse, Nanjundaswamy M Hemmaragala
No abstract text is available yet for this article.
June 26, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28662923/the-influence-of-experimental-conditions-on-the-final-result-of-photoinhibition-of-staphylococcus-aureus
#20
M C Decarli, T Q Corrêa, J D Vollet-Filho, V S Bagnato, C W O Souza
BACKGROUND: By and large, phototherapies are a promising approach to promote inactivation of microorganisms using light exposure, providing an effective alternative to control multidrug-resistant bacterial infections. Considering this, intercomparison between experiments is vitally important. Most experiments are performed using multiwell plates in which the volume of the culture medium is not standardized. In such cases, light attenuation and the distance it travels, which also depends on the volume and vessel geometry, can lead to different results...
June 26, 2017: Photodiagnosis and Photodynamic Therapy
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