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Photodiagnosis and Photodynamic Therapy

Sergio Varela Kellesarian, Vanessa Ros Malignaggi, Hasham Abdullah Majoka, Abdulaziz A Al-Kheraif, Tammy Varela Kellesarian, Georgios E Romanos, Fawad Javed
BACKGROUND: The aim of the present systematic review was to assess the efficacy of laser-assisted (low level laser therapy [LLLT], high intensity laser therapy [HILT], or antimicrobial photodynamic therapy [aPDT]) scaling and root planing (SRP) compared with SRP alone on the expression of inflammatory cytokines in the gingival crevicular (GCF) of patients with chronic periodontitis (CP). METHODS: In order to address the focused question: "What is the efficacy of SRP with and without laser and/or aPDT on the expression of pro-inflammatory cytokines in the GCF of patients with CP?" an electronic search without time or language restrictions was conducted up to and including February 2017 in indexed databases using various key words...
February 20, 2017: Photodiagnosis and Photodynamic Therapy
M-Ali H Al-Akhras, Khaled Aljarrah, Borhan Albiss, Duaa Al-Khalili
BACKGROUND: Iron oxide (Fe3O4) nanoparticles (IO-NP) were recently employed in medical applications as a diagnostic and drug carrier. Photofrin (PF) is a photosensitizer that clinically used in Photodynamic therapy (PDT). STUDY DESIGN: the photosensitivity of the PF and Rose Bengal (RB) mixed with (IO-NP) on red blood cells (RBCs) lysis was investigated. Second, Photohemolysis for post-irradiation (delayed) and during irradiation (continuous) with PF, RB and IO-NP combinations at different concentrations was investigated...
February 19, 2017: Photodiagnosis and Photodynamic Therapy
Johan Richter, Neda Haj-Hosseini, Martin Hallbeck, Karin Wårdell
BACKGROUND: Visualization of the tumor is crucial for differentiating malignant tissue from healthy brain during surgery, especially in the tumor marginal zone. The aim of the study was to introduce a fluorescence spectroscopy-based hand-held probe (HHF-probe) for tumor identification in combination with the fluorescence guided resection surgical microscope (FGR-micsorcope), and evaluate them in terms of diagnostic performance and practical aspects of fluorescence detection. METHODS: Eighteen operations were performed on 16 patients with suspected high-grade glioma...
February 18, 2017: Photodiagnosis and Photodynamic Therapy
Reza Fekrazad, Arash Poorsattar Bejeh Mir, Mina Kahyaie Aghdam, Vadood Ghasemi Barghi
BACKGROUND: Superficial mycotic skin infections which are predominantly caused by Trichophyton rubrum, poorly responses to conventional therapies. A great amount of attention has focused on to find more effective treatments. The current work is aimed to compare the effectiveness of phoinactivation of Trichophyton rubrum by two relatively new photosensitizers: a phenothiazinium dye(New methylene blue) and Indocyanine green (EmunDo(®)). MATERIALS AND METHODS: A Final inoculum of T...
February 18, 2017: Photodiagnosis and Photodynamic Therapy
Anita Olejek, Iwona Gabriel, Anna Bilska-Janosik, Iwona Kozak-Darmas, Aleksandra Kawczyk-Krupka
BACKGROUND: Lichen sclerosus (LS) is a difficult to treat, often relapsing disease with unknown background. An autoimmune diseases coexist with LS. Over recent years photodynamic therapy (PDT) has been shown to be noninvasive and successful therapeutic approach for the effective treatment many conditions. However, the change of immune status of the patients based on ANA antibodies has not been yet reported. Our aim was to observe the clinical response followed by possible changes in autoimmune antibodies levels before and after PDT...
February 17, 2017: Photodiagnosis and Photodynamic Therapy
Maryam Pourhajibagher, Abbas Monzavi, Nasim Chiniforush, Mohammad Moein Monzavi, Shaghayegh Sobhani, Sima Shahabi, Abbas Bahador
BACKGROUND: Aggregatibacter actinomycetemcomitans is an etiological agent of both chronic and aggressive periodontitis. Dissemination of A. actinomycetemcomitans from the oral cavity and initiation of systemic infections has led to new approaches for treatment being needed. In this study, a series of experiments presented investigated the effect of methylene blue (MB)-mediated antimicrobial photodynamic therapy (aPDT) on cell viability and expression of fimbria-associated gene (rcpA) in A...
February 16, 2017: Photodiagnosis and Photodynamic Therapy
Tomohiro Osaki, Yuki Kawase, Hiroshi Iseki, Shinji Kishimoto, Soko Ikuta, Yoshihiro Muragaki, Kazuo Azuma, Yusuke Murahata, Takeshi Tsuka, Norihiko Ito, Tomohiro Imagawa, Yoshiharu Okamoto
BACKGROUND: Photodynamic therapy (PDT) uses a photosensitizer and light to destroy abnormal cells. Talaporfin sodium (NPe6) is a second-generation photosensitizer. METHODS: We evaluated the toxic effects of different combinations of laser and NPe6 doses on squamous cell carcinoma (KLN205) and sarcoma (Meth A) cell lines. The cells were incubated with 0, 5, 10, or 30μg/mL NPe6 for 24h. The cells were then irradiated with 0, 5, 15, or 30mW/cm(2) of laser power, and 0, 1, 5, 10, or 20J/cm(2) of laser energy...
February 13, 2017: Photodiagnosis and Photodynamic Therapy
Yan Tang, Hongfu Xie, Ji Li, Dan Jian
BACKGROUND: Plenty of researches focused on treatment efficiency and/or treatment reactions of photodynamic therapy (PDT) on port-wine stain (PWS). But few studies reported the association between them. Hence, here we investigated the association between the treatment efficiency and treatment reactions after Hemoporfin mediated photodynamic therapy (HMME-PDT) on PWS through a prospective study. METHODS: Patients (n=50) with PWS were randomly assigned to the HMME group or the placebo group...
February 12, 2017: Photodiagnosis and Photodynamic Therapy
Wenna Li, Qiang Xie, Linglin Lai, Zhentao Mo, Xiaofang Peng, Ennian Leng, Dandan Zhang, Hongxia Sun, Yiqi Li, Wenjie Mei, Shuying Gao
BACKGROUND: Photodynamic therapy (PDT) is a promising new anti-tumor treatment strategy. Photosensitizer is one of the most important components of PDT. In this work, the anticancer activities of PDTs mediated by six new ruthenium porphyrin complexes were screened. The mechanisms of the most efficacious candidate were investigated. METHODS: Photocytotoxicity of the six porphyrins was tested. The most promising complex, Rup-03, was further investigated using Geimsa staining, which indirectly detects reactive oxygen species (ROS) and subcellular localization...
February 10, 2017: Photodiagnosis and Photodynamic Therapy
Keyvan Moghissi, Kate Dixon
No abstract text is available yet for this article.
February 10, 2017: Photodiagnosis and Photodynamic Therapy
Kate C Blanco, Natalia M Inada, Fernanda M Carbinatto, André Luiz Giusti, Vanderlei S Bagnato
No abstract text is available yet for this article.
February 8, 2017: Photodiagnosis and Photodynamic Therapy
K B E Friis, L Themstrup, G B E Jemec
BACKGROUND: Optical coherence tomography (OCT) is a real-time non-invasive imaging tool, introduced in dermatology in the late 1990s. OCT uses near-infrared light impulses to produce images which can be displayed in cross-sectional and en-face mode. The technique has been used to image skin diseases especially non-melanoma skin cancer including actinic keratosis (AK). Morphological characteristics of AK can be visualized in OCT images and can be used for diagnosis as well as disease monitoring...
February 7, 2017: Photodiagnosis and Photodynamic Therapy
Dong Xue, Lu Tang, Yuhao Bai, Qian Ding, Pengcheng Wang, Ying Zhao
PURPOSE: To evaluate the clinical efficacy of photodynamic therapy (PDT) adjunctive to scaling and root planing (SRP) in patients with untreated chronic periodontitis based on the up-to-date evidence. METHODS: MEDLINE and the Cochrane Library were systematically searched to identify eligible random controlled trials (RCTs), supplemented by a manual literature search. Mean differences (MD) and the corresponding 95% confidence intervals (CI) of probing depth (PD) reduction and clinical attachment level (CAL) gain were synthesized...
February 7, 2017: Photodiagnosis and Photodynamic Therapy
Luana Niculescu, Erhard Bierhoff, Daniela Hartmann, Thomas Ruzicka, Carola Berking, Tanja von Braunmühl
No abstract text is available yet for this article.
February 5, 2017: Photodiagnosis and Photodynamic Therapy
Seung-Hwan Choi, Tae-Hoon Kim, Ki-Hoon Song
BACKGROUND: Iontophoresis is a transdermal drug-delivery technique that enhances the transport of ionic species across membranes and may have significant benefit for the treatment of actinic keratosis (AK) by ablative fractional laser-primed photodynamic therapy (AFL-PDT). The aim of this study were to compare the efficacy, recurrence rate, cosmetic outcome and safety of iontophoresis-assisted AFL-PDT with 2hours of incubation vs. those of conventional AFL-PDT with 2- and 3-hour incubation in patients with facial and scalp AK...
February 3, 2017: Photodiagnosis and Photodynamic Therapy
Elisabetta Merigo, Stefania Conti, Tecla Ciociola, Carlo Fornaini, Luciano Polonelli, Giuseppe Lagori, Maddalena Manfredi, Paolo Vescovi
BACKGROUND: Studies on photodynamic inactivation against microorganisms had a great development in recent years. The aim of this work was to test the application of different laser wavelengths with or without different photosensitizing dyes on Candida albicans cells in vitro and in photodynamic therapy protocols in vivo in larvae of Galleria mellonella. METHODS: Laser application was realized on C. albicans cells suspended in saline solution or cultured on solid medium for the in vitro study, and in a model of G...
January 24, 2017: Photodiagnosis and Photodynamic Therapy
Tariq Abduljabbar, Mansour Al-Askar, Mohammed K Baig, Zeyad H AlSowygh, Sergio Varela Kellesarian, Fahim Vohra
OBJECTIVE: The aim was to assess the efficacy of antimicrobial photodynamic therapy (aPDT) in the inactivation of oral fungal colonization among cigarette smokers and non-smokers with denture stomatitis (DS). METHODS: A questionnaire was used to gather demographic information. Clinical oral examination was performed to determine location of denture in the jaws and oral erythematous lesions. Presence of fungal hyphae in smokers and non-smokers was confirmed using exfoliative cytology...
January 24, 2017: Photodiagnosis and Photodynamic Therapy
Kavitha Rani P R, Annette Fernandez, Shiny P Laila, Arunkumar B, Sreelakshmi C S, Vishnu V S
A phenaxazone compound [5H-Benzo[a]phenoxazin-5-one (BP)]along with an aminoquinone[2-[(o-hydroxyphenyl)amino]-1,4-naphthaquinone (HAN)] derivatives were synthesized from lawsone using ultrasound irradiation technique. The structure of the compounds were characterized by elemental analysis and various spectral studies. Optoelectronic properties were studied using Schrodinger material science suit (2015). The compounds exhibit fluorescence emission in longer wave length it may find applications in photodynamic therapy...
January 22, 2017: Photodiagnosis and Photodynamic Therapy
Wenbo Bu, Xiulian Xu, Yan Wang, Liming Huang, Rong Zeng, Xu Chen, Fang Fang
Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease in the area of the apocrine sweat glands. The treatment of HS is relatively difficult. Therefore, surgery combined with PDT was applied to treat 7 cases of patients in this study, and treatment efficacy was observed. Simple surgical incisions and drainage were performed for patients with Hurley grade I. Surgical incisions and drainage as well as the removal of necrotic tissues were performed for patients with grades II and III. Immediately after surgery, PDT was performed...
January 21, 2017: Photodiagnosis and Photodynamic Therapy
Lama Misba, Sahar Zaidi, Asad U Khan
BACKGROUND: Antimicrobial photodynamic therapy (APDT) is a process that generates reactive oxygen species (ROS) in presence of photosensitizer, visible light and oxygen which destroys the bacterial cells. We investigated the photoinactivation efficiency of phenothiazinium dyes and the effect of ROS generation on Gram positive and Gram negative bacterial cell as well as on biofilm. MATERIAL AND METHODS: Enterococcus faecalis and Klebsiella pneumonia were incubated with all the three phenothiazinium dyes and exposed to 630nm of light...
January 21, 2017: Photodiagnosis and Photodynamic Therapy
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