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Photodiagnosis and Photodynamic Therapy

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https://www.readbyqxmd.com/read/28546112/pemphigus-vulgaris-induced-by-5-aminolaevulinic-acid-based-photodynamic-therapy
#1
Qian Zhou, Peiru Wang, Linglin Zhang, Bo Wang, Lei Shi, Uma Keyal, Anil Kumar Bhatta, Guolong Zhang, Xiuli Wang
Pemphigus vulgaris (PV) is an autoimmune disorder resulting from the interaction between autoantibodies and desmoglein. Here, we report a case of PV developed after 5-aminolaevulinic acid-based photodynamic therapy (ALA-PDT). The harmful and deleterious effects of UV radiation on the onset, during course, and perpetuation of PV have been observed for decades. Correlation between reactive oxygen species (ROS) and PV have also been reported. Oxidative proteins, which are modified by ROS, and subsequent production of antibodies by immune system seem to be responsible for PV developed following ALA-PDT...
May 22, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28546111/comparative-effect-of-photodynamic-therapy-on-separated-or-mixed-cultures-of-streptococcus-mutans-and-streptococcus-sanguinis
#2
Vanesa Pérez-Laguna, Luna Pérez-Artiaga, Verónica Lampaya-Pérez, Santiago Camacho López, Isabel García-Luque, María José Revillo, Santi Nonell, Yolanda Gilaberte, Antonio Rezusta
Antimicrobial photodynamic therapy (aPDT) has shown to exert a bactericidal effect against Streptococcus sanguinis and Streptococcus mutans. However, this efficacy has been reported for either type of bacteria separately. Bacterial suspensions of both strains, separately or together, were treated with concentrations of methylene blue (MB) and rose bengal (RB). Suspensions were irradiated with a light-emitting diode lamp (λ center at 625nm for MB and λ center at 515nm for RB) using a fluence of 18J/cm(2). RB-aPDT at concentrations of 0...
May 22, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28526592/photodynamic-therapy-in-the-treatment-of-vulvar-lichen-sclerosus
#3
Agnieszka Maździarz, Beata Osuch, Magdalena Kowalska, Agnieszka Nalewczyńska, Beata Śpiewankiewicz
BACKGROUND: Vulvar lichen sclerosus is a chronic and incurable disease that causes various unpleasant symptoms and serious consequences. OBJECTIVE: The purpose of the study was to assess the effectiveness of photodynamic therapy in the treatment of vulvar lichen sclerosus. METHODS: Participants in the study included 102 female patients aged 19-85 suffer from vulvar lichen sclerosus. The patients underwent photodynamic therapy (PDT). In the course of PDT the 5% 5- aminolevulinic acid was used in gel form...
May 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28506773/antimicrobial-photodynamic-therapy-with-photosensitizer-in-ethanol-improves-oxidative-status-and-gingival-collagen-in-a-short-term-in-periodontitis
#4
Fernanda Maia Pillusky, Raquel Cristine Silva Barcelos, Luciana Taschetto Vey, Luisa Machado Barin, Victor de Mello Palma, Roberto Marinho Maciel, Karla Zanini Kantorski, Marilise Escobar Bürger, Cristiane Cademartori Danesi
BACKGROUND: This study evaluated the antimicrobial photodynamic therapy (aPDT) effects using the methylene blue (MB) in ethanol 20% on systemic oxidative status and collagen content from gingiva of rats with periodontitis. METHODS: Rats were divided into five experimental groups: NC (negative control; no periodontitis); PC (positive control; periodontitis without any treatment); SRP (periodontitis and scaling and root planing), aPDT I (periodontitis and SRP+aPDT+MB solubilized in water), and aPDT II (periodontitis and SRP+aPDT+MB solubilized in ethanol 20%)...
May 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28506772/treatment-of-epithelioid-angiosarcoma-with-topical-ala-pdt-in-the-course-of-surgery
#5
Yang Gao, Wen-Sheng Wang, Hai-Lin Wang, Jia Liu, Yuan-Gang Lu
BACKGROUND: Epithelioid angiosarcoma is a kind of high grade malignancy sarcoma of soft tissue, which is hard to diagnose and completely exsect without causing functional and cosmetic problems. Moreover, the high rate of recurrence is hard to handle. Photodynamic therapy is a novel treatment protocol which can selectively destroy tumor cell with good functional and cosmetic outcomes. METHODS: This is a case about a 81 years old patient with Epithelioid angiosarcoma in the right medial angle of eye, which received surgery and photodynamic therapy...
May 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28502877/irradiance-dependence-of-the-conduction-block-of-an-in-vitro-cardiomyocyte-wire
#6
Emiyu Ogawa, Mariko Kurotsu, Tsunenori Arai
BACKGROUND: To obtain therapeutic condition precisely by in vitro experiment, we studied the irradiance dependence of the electrical conduction blockage caused by a photodynamic reaction using a high extracellular concentration of talaporfin sodium on a novel in vitro cardiomyocyte electrical conduction wire. METHODS: The cardiomyocyte wires were constructed on patterned cultivation cover glass, which had cultivation areas 60μm in width, and a maximum length of 10mm...
May 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28502876/novel-strategy-in-giant-cutaneous-squamous-cell-carcinoma-treatment-the-case-experience-in-a-combination-of-photodynamic-therapy-and-surgery
#7
Wenbo Bu, Yan Wang, Xu Chen, Fang Fang
Case A 90-year-old Chinese man presented to our hospital with a one-year history of a large neoplasm on his right cheek (figure). The patient did not have subjective symptoms but emitted an obvious stench. However, the patient has significant embarrassment and difficult on social interaction due to abnormal appearance and foul smell from lesion. A clinical examination showed that the tumor size was 7cm * 6.5cm * 1.5cm. An X-ray examination showed that the deep tumor was not associated with any bone destruction...
May 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28502875/efficacy-of-photodynamic-therapy-versus-antibiotics-as-an-adjunct-to-scaling-and-root-planing-in-the-treatment-of-periodontitis-a-systematic-review-and-meta-analysis
#8
REVIEW
Zohaib Akram, Tahira Hyder, Nawwaf Al-Hamoudi, Munerah Saleh Binshabaib, Shatha Subhi Alharthi, Ayesha Hanif
BACKGROUND: To determine whether treatment with antimicrobial photodynamic therapy (aPDT) as an adjunct to scaling and root planing (SRP) yield better clinical periodontal outcomes than antibiotics (AB) as adjunct to SRP in periodontitis. METHODS: Electronic searches were conducted in databases (MEDLINE, PubMed, EMBASE, SCOPUS, Cochrane Central Register of Controlled Trials and Cochrane Oral Health Group Trials Register databases) up to and including April 2017...
May 11, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28495508/the-effect-of-ala-pdt-under-normoxia-and-cobalt-chloride-cocl2-induced-hypoxia-on-adhesion-molecules-icam-1-vcam-1-secretion-by-colorectal-cancer-cells
#9
Aleksandra Kawczyk-Krupka, Zenon Czuba, Beata Kwiatek, Sebastian Kwiatek, Magdalena Krupka, Karolina Sieroń
BACKGROUND: The most fundamental problem in cancer biology research is to understand the mechanisms of cancer cell resistance to oncological therapies. Literature reports emphasize the important role of adhesion molecules: intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 (ICAM-1 and VCAM-1) in cancer progression and resistance to treatment. Photodynamic therapy (PDT) could become the component of a personalized approach to colorectal cancer, therefore we examined the effects of ALA (δ-aminolevulinic) acid PDT in normoxia and under cobalt chloride (CoCl2)-induced hypoxia on ICAM-1 and VCAM-1 secretion by colorectal cancer cells...
May 8, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28478107/endobronchial-photodynamic-therapy-under-fluorescence-control-photodynamic-theranostics
#10
Andrey Leonidovich Akopov, Anatoliy Aleksandrovich Rusanov, Garry Vazgenovich Papayan, Nikita Vladimirovich Kazakov, Andrey Valeryevich Gerasin, Margarita Anzorovna Urtenova
BACKGROUND: Photodynamic therapy (PDT) has several advantages. However, one of the disadvantages is its inability to be individualized according to biological characteristics of malignant tumors. The objective of this study was to investigate a strategy for individualized endobronchial PDT in the treatment of centrally located non-small cell lung cancer. METHODS: New approach suggests taking fluorescence-based measurements of chlorine E6 photosensitizer (PS) accumulation in the malignant tumor tissue, and assess PS consumption rate during PDT...
May 3, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28465165/chlorin-e6-conjugated-copper-sulfide-nanoparticles-for-photodynamic-combined-photothermal-therapy
#11
Subramaniyan Bharathiraja, Panchanathan Manivasagan, Madhappan Santha Moorthy, Nhat Quang Bui, Kang Dae Lee, Junghwan Oh
The photo-based therapeutic approaches have attracted tremendous attention in recent years especially in treatment and management of tumors. Photodynamic and photothermal are two major therapeutic modalities which are being applied in clinical therapy. The development of nanomaterials for photodynamic combined photothermal therapy has gained significant attention for its treatment efficacy. In the present study, we designed chlorin e6 (Ce6) conjugated copper sulfide (CuS) nanoparticles (CuS-Ce6 NPs) through amine functionalization and the synthesized nanoparticles act as a dual-model agent for photodynamic therapy and photothermal therapy...
April 29, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28465164/fluorescence-analysis-of-a-tumor-model-in-the-chorioallantoic-membrane-used-for-the-evaluation-of-different-photosensitizers-for-photodynamic-therapy
#12
Hilde Harb Buzzá, Amanda C Zangirolami, Arthur Davis, Pablo A Gómez-García, Cristina Kurachi
The development of a tumor in the chicken chorioallantoic membrane (CAM) enables a more individualized understanding of the dynamics of the photosensitizer (PS) interaction with the tumor blood vessels and cells. Photogem(®) and 5-aminolevulinic acid (ALA), a protoporphyrin IX (PpIX) precursor, were used as PS and their red fluorescence enabled the monitoring of PS dynamic distribution in the vessels and in the tumor. With a tumor model in CAM and fluorescence assessment, the aim of this study was to evaluate the PDT parameters comparing different photosensitezers...
April 29, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28457851/photodynamic-therapy-with-epidermal-ablation-using-fractional-carbon-dioxide-laser-in-the-treatment-of-bowen-s-disease-a-case-series
#13
Jae Min Sung, You Chan Kim
No abstract text is available yet for this article.
April 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28457850/effectiveness-of-flow-cytometry-for-brain-tumor-excision
#14
LETTER
George A Alexiou, George Vartholomatos, Georgios S Markopoulos, Spyridon Voulgaris, Athanasios P Kyritsis
No abstract text is available yet for this article.
April 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28457849/chair-side-detection-of-prevotella-intermedia-in-mature-dental-plaque-by-its-fluorescence
#15
Yoshiaki Nomura, Hiroaki Takeuchi, Masaaki Okamoto, Kaoru Sogabe, Ayako Okada, Nobuhiro Hanada
BACKGROUND: Prevotella intermedia/nigrescens is one of the well-known pathogens causing periodontal diseases, and the red florescence excited by the visible blue light caused by the protoporphyrin IX in the bacterial cells could be useful for the chair-side detection. The aim of this study was to evaluated levels of periodontal pathogen, especially P. intermedia in clinical samples of red fluorescent dental plaque. METHODS: Thirty two supra gingival plaque samples from six individuals were measured its fluorescence at 640nm wavelength excited by 409nm...
April 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28457848/evaluation-of-methylene-blue-as-photosensitizer-in-promastigotes-of-leishmania-major-and-leishmania-braziliensis
#16
Juliana Guerra Pinto, Jaciara Fagundes, André Henrique Correia Pereira, Josane Mittmann, Leandro José Raniero, Juliana Ferreira-Strixino
The cutaneous leishmaniasis is caused by the protozoan of the genus Leishmania. It is considered by WHO as a public health issue and a neglected disease, which affects rural workers and it is also a risk to travelers in endemic areas. The conventional treatment is toxic and leads to severe side effects. The photodynamic therapy has been studied as an alternative treatment to cutaneous leishmaniasis. This study aimed to evaluate the methylene blue internalization and the impact of the PDT in the viability and morphology of Leishmania major and Leishmania braziliensis promastigote in culture medium...
April 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28457847/role-of-mechanical-curettage-with-and-without-adjunct-antimicrobial-photodynamic-therapy-in-the-treatment-of-peri-implant-mucositis-in-cigarette-smokers-a-randomized-controlled-clinical-trial
#17
Fawad Javed, Munerah Saleh BinShabaib, Shatha Subhi Alharthi, Talat Qadri
OBJECTIVE: The aim of the present 12-weeks follow-up randomized clinical trial was to investigate the outcome of mechanical curettage (MC) with or without adjunct antimicrobial photodynamic therapy (aPDT) in the treatment of peri-implant mucositis in cigarette smokers. METHODS: Therapeutically, subjects with peri-implant mucositis were divided into 2 groups: (a) Group-A: MC+aPDT; and (b) Group-B: MC alone (control group). In both groups, peri-implant plaque index (PI), bleeding on probing (BOP) and probing pocket depth (PPD) were gauged at baseline and after 12-weeks follow-up...
April 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28450262/evaluation-of-photodynamic-therapy-in-treatment-of-oral-erosive-lichen-planus-in-comparison-with-topically-applied-corticosteroids
#18
Diana Mostafa, Eglal Moussa, Manal Alnouaem
BACKGROUND: The treatment of erosive oral lichen planus represents a therapeutic challenge. Despite numerous existing remedies, some of these treatments display disappointed results. Since it is a chronic disease with no current cure, the best treatment should target mainly the reduction of the duration and severity of symptomatic outbreaks with minimal side effects. To date, corticosteroids remain the first choice of treatment for oral lichen planus (OLP) patients. Although, topical corticosteroids have been found to be the safest and the most successful agents in the treatment of OLP, their prolonged use may cause mucosal problems and may lead to systemic complications...
April 24, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28450261/monitoring-gene-expression-of-rcpa-from-aggregatibacter-actinomycetemcomitans-versus-antimicrobial-photodynamic-therapy-by-relative-quantitative-real-time-pcr
#19
Maryam Pourhajibagher, Nasim Chiniforush, Sima Shahabi, Shaghayegh Sobhani, Mohammad Moein Monzavi, Abbas Monzavi, Abbas Bahador
BACKGROUND: Aggregatibacter actinomycetemcomitans is an important pathogen that is frequently found in various infections, particularly aggressive periodontitis. In this study, we described the outcome of the expression level of A. actinomycetemcomitans virulence factor following treatment by antimicrobial photodynamic therapy (aPDT) with indocyanine green (ICG) as a photosensitizing agent. MATERIALS AND METHODS: To determine the aPDT effect on the cell-surviving assay and expression ratio of the rcpA gene in A...
April 24, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28442314/photodynamic-therapy-in-the-management-of-basal-cell-carcinoma-retrospective-evaluation-of-outcome
#20
Waseem Jerjes, Zaid Hamdoon, Colin Hopper
INTRODUCTION: Photodynamic therapy (PDT) is a relatively new method of treating various kinds of pathologies. In this retrospective study, a total of 148 patients with basal cell carcinoma (BCC) were treated with surface illumination methyl aminolevulinate - photodynamic therapy (MAL-PDT) or meta-tetrahydroxyphenylchlorin (mTHPC-PDT). Comparisons with the clinical features, rate of recurrence and overall outcome were made. MATERIALS AND METHODS: Surface illumination PDT was offered under local or general anaesthesia...
April 22, 2017: Photodiagnosis and Photodynamic Therapy
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