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Photodiagnosis and Photodynamic Therapy

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https://www.readbyqxmd.com/read/28733050/the-optical-imaging-of-an-idiopathic-paracentral-acute-middle-maculopathy-chinese-young-man-and-review-of-the-literatures
#1
REVIEW
Yanyan Chen, Yuedong Hu
We report a case of idiopathic paracentral acute middle maculopathy with typical optical imaging and clinical features. A 26-year-old Chinese policeman presented with a 20-day history of paracentral scotoma in the left eye after early wake-up and long-time working in front of computer the day before. He experienced sudden-onset strong flash in his left eye. Paracentral scotoma appeared in his left eye after 6hours of rest. The general history was negative. His best-corrected visual acuity was 20/20 OU. Anterior segment, dilated fundus examination, papillary evaluation and intraocular pressure were normal...
July 18, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28716739/phototoxicity-in-a-laryngeal-cancer-cell-line-enhanced-by-a-targeting-amphiphilic-chlorin-photosensitizer
#2
Milene N O Moritz, Carlos Rossa, Kleber T de Oliveira, Marciana P Uliana, Janice R Perussi
BACKGROUND: Photodynamic therapy (PDT) has been established in several countries as an alternative therapy for the treatment of various malignancies. This therapy involves the incorporation of a photosensitizer (PS) that is activated by visible light and form reactive oxygen species leading to target cell death by apoptosis or necrosis. Previously, our group has demonstrated that CHL-T (semi-synthesized from chlorophyll a and containing a linked solubilizing group TRISMA(®)) presented a pronounced potential to induce death in HeLa cell line after PDT...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28716738/photodynamic-therapy-and-pain-a-systematic-review
#3
Jennifer Maria Ang, Irbaz Bin Riaz, Muhammad Umar Kamal, Gyorgy Paragh, Nathalie C Zeitouni
Photodynamic therapy (PDT) is an effective treatment for actinic keratoses and early skin cancers, and the only office procedure to control field cancerization. Procedure-associated pain limits widespread PDT use and by early termination of treatment can decrease overall therapeutic efficacy. Here we review and assess reported interventions on PDT-associated pain, in order to identify the most promising methods to manage treatment-associated pain and identify focus for future studies. Literature search was performed using MEDLINE, EMBASE, and the Cochrane Library by two independent reviewers to select publications that assessed and compared pain quantitatively during PDT treatment for actinic keratoses, basal cell carcinomas, and/or in situ squamous cell carcinomas...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28684320/focal-choroidal-excavation-and-a-traumatic-macular-hole-secondary-to-accidental-q-switched-nd-yag-laser
#4
Yuanlu Shuai, Xianglei Chen, Wangyi Fang, Jia Li, Weizhong Ge, Songtao Yuan, Qinghuai Liu
Today, the widespread use of laser instruments in various fields has resulted in many accidental retinal injuries. Here we describe a rare clinical case of full-thickness macular hole (MH) and focal choroidal excavation (FCE) caused by a 1064-nm Q-switched Nd:YAG laser. After pars plana vitrectomy and the following 14 months, consecutive optical coherence tomography imagings showed closure of the MH. Visual acuity improved even in the absence of the outer retina and in the presence of FCE. We speculate that different focusing effects of the unexpected Nd:YAG laser which target different levels of retinal tissue generates diverse prognosis...
July 3, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28669793/comparing-clinical-effects-of-photodynamic-therapy-as-a-novel-method-with-topical-corticosteroid-for-treatment-of-oral-lichen-planus
#5
Sedigheh Bakhtiari, Seyyed Masoud Mojahedi, Saranaz Azari-Marhabi, Mahshid Namdari, Zahra Elmi Rankohi
BACKGROUND: Oral lichen planus is an autoimmune disorder with several challenges in treatment. Photodynamic therapy has been proposed as a new treatment option for the disease. AIM: The present study compared the clinical effects of the photodynamic therapy and dexamethasone mouthwash in the treatment of oral lichen planus lesions. MATERIALS AND METHODS: In this randomized clinical trial, 30 patients with oral lichen planus were included.15 patients were treated with 5% methylene blue mediated photodynamic therapy using Fotosan device for 30seconds (630nm wavelength and 7...
June 29, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28669792/preparation-and-characterization-of-bioadhesive-system-containing-hypericin-for-local-photodynamic-therapy
#6
Fernanda Belincanta Borghi-Pangoni, Mariana Volpato Junqueira, Sabrina Barbosa de Souza Ferreira, Larissa Lachi Silva, Bruno Ribeiro Rabello, Lidiane Vizioli de Castro, Mauro Luciano Baesso, Andréa Diniz, Wilker Caetano, Marcos Luciano Bruschi
Hypericin (Hyp) is a natural photoactive pigment utilized in the treatment of different types of cancer and antimicrobial inactivation using photodynamic therapy (PDT). Hyp is poorly soluble in water conducing to problems of administration, getting closeness contact with the site, and availability. Therefore, this study aimed to develop bioadhesive thermoresponsive system containing Hyp for local PDT. I this sense, carbomer 934P, poloxamer 407, and Hyp were used to prepare the thermoresponsive bioadhesive formulations...
June 29, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28666974/application-of-photodynamic-therapy-laser-therapy-and-a-cellulose-membrane-for-calcaneal-pressure-ulcer-treatment-in-a-diabetic-patient-a-case-report
#7
Luciano Pereira Rosa, Francine Cristina da Silva, Regiane Lima Vieira, Beatriz Rocha Tanajura, Alana Gonçalves da Silva Gusmão, Janeide Muritiba de Oliveira, Nathalia Aparecida Campanário Dos Santos, Vanderlei Salvador Bagnato
Diabetes mellitus is a metabolic disorder in which a person has high blood glucose levels due to inadequate insulin production by the pancreas. Wounds in these individuals cannot heal properly over time due to circulatory changes that hinder and stagnate the healing process. We report the case of an 82-year-old female type 2 diabetes mellitus carrier, presenting to clinical-dermatological examination pressure ulcer (PU) in the right calcaneus region. The patient was treated with photodynamic therapy using curcumin and blue light-emitting diodes (LEDs), laser therapy, and the application of a cellulose membrane in order to promote ulcer decontamination by local action, accelerate wound healing, and maintain favorable conditions of asepsis and moisture, respectively...
June 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28666973/ala-pdt-combined-with-antibiotics-for-the-treatment-of-atypical-mycobacterial-skin-infections-outcomes-and-safety
#8
Kedai Sun, Hang Yang, Xianqiong Huang, Nanpeng Gong, QinQin, Weiping Lu, Xia Lei
BACKGROUND: Photodynamic therapy (PDT) has been shown to be a very successful new therapy in clinical practice, and its usefulness as a treatment for bacterial infections has been gradually recognized by researchers, who believe it has very good clinical prospects. Atypical mycobacterial skin infections are a type of rare refractory infection. The aim of this study was to evaluate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with antibiotics for the treatment of atypical mycobacterial skin infections...
June 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28662924/anticancer-effects-elicited-by-combination-of-rubus-extract-with-phthalocyanine-photosensitiser-on-mcf-7-human-breast-cancer-cells
#9
Blassan P George, Heidi Abrahamse, Nanjundaswamy M Hemmaragala
No abstract text is available yet for this article.
June 26, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28662923/the-influence-of-experimental-conditions-on-the-final-result-of-photoinhibition-of-staphylococcus-aureus
#10
M C Decarli, T Q Corrêa, J D Vollet-Filho, V S Bagnato, C W O Souza
BACKGROUND: By and large, phototherapies are a promising approach to promote inactivation of microorganisms using light exposure, providing an effective alternative to control multidrug-resistant bacterial infections. Considering this, intercomparison between experiments is vitally important. Most experiments are performed using multiwell plates in which the volume of the culture medium is not standardized. In such cases, light attenuation and the distance it travels, which also depends on the volume and vessel geometry, can lead to different results...
June 26, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28647617/photodynamic-therapy-with-epidermal-ablation-using-fractional-co2-laser-for-treating-superficial-basal-cell-carcinoma-a-case-series
#11
Jae Min Sung, You Chan Kim
No abstract text is available yet for this article.
June 21, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28647616/photodynamic-therapy-in-dermatology-beyond-non-melanoma-cancer-an-update
#12
REVIEW
Xiang Wen, Yong Li, Michael R Hamblin
Photodynamic therapy (PDT) employs a photosensitizer (PS) and visible light in the presence of oxygen, leading to production of cytotoxic reactive oxygen species, which can damage the cellular organelles and cause cell death. In dermatology PDT has usually taken the form of topical application of a precursor in the heme biosynthesis pathway, called 5-aminolevulinic acid (or its methyl ester), so that an active PS, protoporphyrin IX accumulates in the skin. As PDT enhances dermal remodeling and resolves chronic inflamation, it has been used to treat cutaneous disorders include actinic keratoses, acne, viral warts, skin rejuvenation, psoriasis, localized scleroderma, some non-melanoma skin cancers and port-wine stains...
June 21, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28645784/the-effect-of-antimicrobial-photodynamic-therapy-on-the-expression-of-novel-methicillin-resistance-markers-determined-using-cdna-aflp-approach-in-staphylococcus-aureus
#13
Mohammad Neshvan Hoorijani, Hosein Rostami, Maryam Pourhajibagher, Nasim Chiniforush, Mansour Heidari, Babak Pourakbari, Hossein Kazemian, Kambiz Davari, Vahid Amini, Reza Raoofian, Abbas Bahador
BACKGROUND: Widespread methicillin resistant Staphylococcus aureus (MRSA) and absence of effective antimicrobial agents has led to limited therapeutic options for treating MRSA infection. We aimed to evaluate the effect of antimicrobial photodynamic therapy (aPDT) on the expression of novel identified methicillin resistance markers (NIMRMs) in S. aureus using complementary DNA-Amplified Fragment Length Polymorphism (cDNA-AFLP) approaches to address the therapeutic alternatives for MRSA infections...
June 20, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28629787/oral-cancer-from-the-perspective-of-wide-field-optical-fluorescence-diagnosis-tumor-evolution-and-post-treatment-follow-up
#14
Sérgio Araújo Andrade, Sebastião Pratavieira, Marisa Maria Ribeiro, Vanderlei S Bagnato, Fernando de Pilla Varotti
In this communication, we present that wide-field optical fluorescence might be useful for: the screening of oral lesions that are imperceptible to the naked eye, determination of biopsy area, better definition of treatment, and previous and post-treatment follow-up.
June 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28625924/protoporphyrin-ix-fluorescence-as-potential-indicator-of-psoriasis-severity-and-progression
#15
Bo Wang, Yu-Ting Xu, Li Zhang, Jie Zheng, Ronald Sroka, Hong-Wei Wang, Xiu-Li Wang
BACKGROUND AND OBJECTIVES: In psoriatic lesions, fluorescence diagnosis with blue light can detect protoporphyrin IX accumulation, especially after topical 5-aminolaevulinic acid (ALA) application. However, variable fluorescence distributions, interpersonal variations and long incubation time limit its wide application in clinic. This study is aimed to identify a consistent and convenient method to facilitate diagnosis and evaluation of psoriatic lesions. METHODS: 104 psoriatic lesions from 30 patients were evaluated...
June 15, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28624551/accumulation-of-porphyrins-in-propionibacterium-acnes-by-5-aminolevulinic-acid-and-its-esters
#16
Arisa Ogata, Yuya Hasunuma, Emii Kikuchi, Takuya Ishii, Masahiro Ishizuka, Yoshikazu Tokuoka
We have investigated the accumulation of porphyrins in Propionibacterium acnes (P.acnes) by 5-aminolevulinic acid hydrochloride (ALA) and its esters, ALA methyl ester hydrochloride (mALA), ALA octyl ester hydrochloride (oALA), and ALA benzyl ester hydrochloride (bALA). From the fluorescence spectra of porphyrins accumulated in P.acnes, the order of porphyrin accumulation is as follows: ALA≫mALA≈bALA>oALA (≈0). Moreover, the PDT efficacy is reduced in the order of ALA>mALA≈bALA>oALA (≈without additives)...
June 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28619615/evaluation-of-antimicrobial-activity-of-association-of-chlorhexidine-to-photosensitizer-used-in-photodynamic-therapy-in-root-canals-infected-by-enterococcus-faecalis
#17
Matheus Albino Souza, Guilherme Lima, Bianca Pazinatto, Karolina Frick Bischoff, Huriel Scartazzini Palhano, Doglas Cecchin
INTRODUCTION: The aim of the present study was to evaluate, in vitro, the influence of the addition of chlorhexidine to photosensitiser in the antimicrobial activity of photodynamic therapy in root canals infected by Enterococcus faecalis. METHODS: the root canals of 50 single-rooted human extracted teeth were enlarged up to a file F3 of Pro-Taper system, autoclaved, inoculated with Enterococcus faecalis and incubated for 14 days. The samples were divided into five groups (n=10) according to the protocol of decontamination: G1 (control group) - no procedure was performed; G2-photosensitiser (0...
June 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28619614/rapid-ex-vivo-examination-of-mohs-specimens-using-optical-coherence-tomography
#18
D Rashed, D Shah, A Freeman, R J Cook, C Hopper, C M Perrett
BACKGROUND: Mohs micrographic surgery (MMS) is an effective treatment for certain non-melanoma skin cancers. Optical coherence tomography (OCT) is a biomedical imaging modality that permits high-resolution imaging of the epidermis and dermis with the potential to detect both healthy tissue and tumour. OCT may also provide a means of detecting and differentiating between the various histological subtypes of basal cell carcinomas (BCC) in vivo. OBJECTIVE: The aim of this prospective ex vivo study was to evaluate the efficacy of OCT in recognising healthy and pathological margins of excised BCC lesions and detecting different BCC subtypes...
June 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28619613/does-supplemental-photodynamic-therapy-optimize-the-disinfection-of-bacteria-and-endotoxins-in-one-visit-and-two-visit-root-canal-therapy-a-randomized-clinical-trial
#19
Diego G D Rabello, Bruna J M Corazza, Luciana L Ferreira, Mauro P Santamaria, Ana P M Gomes, Frederico C Martinho
AIM: to evaluate the effectiveness of supplemental photodynamic therapy (PDT) in optimizing the removal of bacteria and endotoxins from primarily infected root canals after one-visit and two-visit treatments. METHODOLOGY: Twenty-four primarily infected root canals with apical periodontitis were selected and randomly divided into one-visit (n=12) and two-visit treatment groups (n=12). Chemo-mechanical preparation (CMP) was performed by using the single-file reciprocating technique+2...
June 12, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28606724/sonodynamic-therapy-a-treatment-developing-from-photodynamic-therapy
#20
REVIEW
Liu Rengeng, Zhang Qianyu, Lang Yuehong, Peng Zhongzhong, Li Libo
Sonodynamic therapy (SDT) as a new non-invasive treatment developed from photodynamic (PDT), it can kill tumor cells specifically and selectively. Moreover, recently studies showed SDT has potential to treat solid tumor, leukemia and atherosclerosis, remove proliferative scars and kill pathogenic microorganism. As SDT has an extensive application prospect, SDT attracts more and more researchers in recently years. This thesis aims at making an informative introduction on SDT. With the assistance of related literature from 2012 to 2016, we introduce the progress of SDT research in six aspects: the therapeutic mechanism of SDT, development of the sound sensitizer, exploration of the size and frequency of ultrasonic energy, application of SDT, comparison between SDT and PDT, and current situation and future of SDT...
June 9, 2017: Photodiagnosis and Photodynamic Therapy
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