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Photodiagnosis and Photodynamic Therapy

Magdalena Sulewska, Ewa Duraj, Stefan Sobaniec, Alfreda Graczyk, Robert Milewski, Marta Wróblewska, Jan Pietruski, Małgorzata Pietruska
BACKGROUND: The aim of the study was to clinically evaluate the efficacy of photodynamic therapy in treatment of reticular oral lichen planus (OLP). METHODS: Fifty patients aged 26-84, with 124 OLP lesions in total, underwent photodynamic therapy (PDT) mediated with topically applied 5% 5-aminolevulinic acid. ALA was activated by a custom-made diode lamp with a high-power LED emitting light at 630 nm and 300 mW delivered through an optical fiber probe. A light exposure dose was 150 J/cm2 ...
November 14, 2018: Photodiagnosis and Photodynamic Therapy
Yuguang Yang, Yunjie Zhang, Xianbiao Zou, Xiaojuan Guo, Hui Lin
OBJECTIVE: To observe the clinical efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating vulval condylomata acuminata (CA) in pregnancy. METHODS: The clinical efficacies of ALA-PDT on 16 cases of CA in pregnancy as well as cryotherapy on 22 cases of CA in pregnancy were analyzed in this prospective study. RESULTS: The treatment group showed a wart clearance rate of 93.8% after 3 PDT treatments, while the control group showed a wart clearance rate of 72...
November 14, 2018: Photodiagnosis and Photodynamic Therapy
Ali Farashahi, Arash Zare-Sadeghi, Ali Shakeri-Zadeh, S Kamran Kamrava, Shayan Maleki, Habib Ghaznavi, Fariborz Faeghi
Gold nanoparticles (AuNPs) have shown potential strength in photothermal therapy of cancer. Several techniques have been developed to investigate local heat generation by AuNPs. However, a sensitive thermal imaging technology with high temporal resolution, minimum invasiveness and high spatial resolution is still lacking. In this research study, by using magnetic resonance thermal imaging (MRTI), we reported a technique for monitoring of heat generation and distribution in an AuNPs loaded agar phantom irradiated by laser...
November 14, 2018: Photodiagnosis and Photodynamic Therapy
Farid Azizi Jalilian
INTRODUCTION: Herpes simplex virus (HSV) is among the most common viruses in humans. HSV1 is often responsible for oral and perioral herpetic lesions. Photodynamic therapy (PDT) is a novel antimicrobial modality that involves the use of laser and a photosensitizer with a specific wavelength. This study aimed to assess and compare the effect of PDT with 810 and 940 nm diode laser and indocyanine green (ICG) photosensitizer on HSV1. METHODS: In this in vitro study, HSV1 isolated from herpes labialis and there were 6 experimental groups...
November 14, 2018: Photodiagnosis and Photodynamic Therapy
Tsun-Chin Huang, Chun-Ju Chen, Shinn-Jyh Ding, Chun-Cheng Chen
Bacterial elimination using antimicrobial photodynamic therapy (aPDT) has been considered an alternative therapeutic modality in peri-implantitis treatment. The present in vitro study was to evaluate the dose-dependent and pH-dependent bactericidal effects of methylene blue (MB)-mediated aPDT at eliminating Gram-negative (P. gingivalis and A. actinomycetemcomitans) and Gram-positive (S. mutans) bacteria on sandblasting, large-grit and acid-etching (SLA)-pretreated titanium alloy. The effects of different MB concentrations (50, 100, and 200 μg/mL), the pH of the MB (4, 7, and 10), and irradiation time (0, 30, and 60 sec) on the bacterial viability and residual lipopolysaccharide (LPS) levels were examined...
November 12, 2018: Photodiagnosis and Photodynamic Therapy
Na-Ri Shin, Jun-Seon Choi
BACKGROUND: This study investigated the relationship between manual dexterity and dental biofilm accumulation in independent older Koreans using Quantitative Light-Induced Fluorescence-Digital (QLF-D). METHODS: This cross-sectional study included 44 participants recruited from senior welfare facilities in South Korea and aged ≥ 65 years. Participants were surveyed using face-to-face structured interviews; manual dexterity was assessed using the Box and Blocks Test...
November 12, 2018: Photodiagnosis and Photodynamic Therapy
A V Dadeko, L Lilge, P Kaspler, T D Murav'eva, A M Starodubtcev, V M Kiselev, V V Zarubaev, G V Ponomarev
Photophysical and in vitro photocytotoxicity studies were performed for the photosensitizer Dimegine, a disodium salt 2.4-di(alpha-methoxyethyl)-deuteroporphyrin-IX with very low systemic toxicity. The singlet oxygen and luminescence quantum yield were ΦΔ  = 0,65 ± 0,06, and Φƒ =0,11 ± 0,01 respectively, and were independent of the excitation wavelength. The photobleaching coefficients for Dimegine dissolved in phosphate buffer (pH 7.4), and DMEM medium at concentration 2 μM/l and in phosphate buffer (pH 7...
November 6, 2018: Photodiagnosis and Photodynamic Therapy
XueLing Mei, Li Wang, Ruina Zhang, Shan Zhong
Daylight photodynamic therapy (dPDT) is suggested to be effective for actinic keratosis (AK). We performed a meta-analysis of randomized controlled trials (RCTs) to compare the efficacy and safety of dPDT versus conventional photodynamic therapy (cPDT) in patients with AK. Relevant studies were identified through a systematic search of PubMed, Embase, and the Cochrane Library. A fixed or random effect model was applied, depending on the heterogeneity. Six RCTs with 369 patients with 5,556 A K lesions that were undergoing dPDT or cPDT with red light and methyl aminolevulinate (MAL) were included...
November 6, 2018: Photodiagnosis and Photodynamic Therapy
Paula Delello Macedo, Sâmara Tfaile Corbi, Guilherme José Pimentel Lopes de Oliveira, Janice Rodrigues Perussi, Anderson Orzari Ribeiro, Rosemary Adriana Chierici Marcantonio
OBJECTIVE: To evaluate the effect of antimicrobial photodynamic therapy (aPDT) using the photosensitizer hypericin-glucamine in the progression of experimentally induced periodontal disease (PD) in rats. MATERIAL AND METHODS: Subgingival ligatures were inserted around the upper second molars of 30 rats. After 7 days (Baseline), the animals were randomly distributed into 3 experimental (n = 5) groups: Hypericin-glucamine; LED (amber LED, 700 mA, 590 nm, 90 mW, 34...
November 3, 2018: Photodiagnosis and Photodynamic Therapy
Nedaa Shamali, Annegret Preuß, Irena Saltsman, Atif Mahammed, Zeev Gross, Georg Däschlein, Beate Röder
Onychomycosis is a fungal nail infection caused primarily by the dermatophytes Trichophyton rubrum and Trichophyton interdigitale or, less frequently, by molds like Aspergillus spp. and Scopulariopsis brevicaulis. Photodynamic treatment of onychomycosis is considered a promising future therapy to overcome the frequent failure of currently used antifungals. In this study, we tested the potential of three photosensitizers for photodynamic inactivation of the onychomycosis causing pathogens T. rubrum, T. interdigitale and S...
November 3, 2018: Photodiagnosis and Photodynamic Therapy
Clara Gómez, Rosa Abellán, Juan Carlos Palma
INTRODUCTION: The complex designs of fixed orthodontic appliances hinder proper access for cleaning, favouring the development of gingival inflammation and white spot lesions around brackets. The aim of this study was to evaluate the effectiveness to avoid these undesirable effects by using two prophylactic methods: Photodynamic Therapy (PDT) and conventional ultrasonic scaler (US), in patients during fixed orthodontic treatment. MATERIALS AND METHODS: Twenty patients under orthodontic treatment for at least 15 months were randomly divided into two groups: PDT mediated by methylene blue (MB) and US...
November 3, 2018: Photodiagnosis and Photodynamic Therapy
Giuliana Campos Chaves, Daniela Alejandra Cusicanqui Méndez, Eliezer Gutierrez, Evandro José Dionisio, Maria Aparecida Andrade Moreira Machado, Thaís Marchini Oliveira, Daniela Rios, Thiago Cruvinel
BACKGROUND: Chlorhexidine digluconate (CHX) is commonly applied as positive control of new antimicrobials, because it is considered the gold-standard for chemical plaque control. In this sense, the aim of this study was to compare the effect of treatments with curcumin-mediated aPDT and CHX in relation to the viability of specific microorganism groups in two distinct times (immediately and 24 h later). METHODS: Dentin caries microcosms were grown on bovine dentin discs (37 °C, anaerobiosis) for 3 days in the Active Attachment Amsterdam Biofilm Model...
November 3, 2018: Photodiagnosis and Photodynamic Therapy
Yuting Li, Bingjie Wang, Saiwei Zheng, Yuan He
OBJECTIVE: The aim of the present study was to systematically review the efficacy of photodynamic therapy (PDT) in the management of oral leukoplakia (OLK). METHODS: This systematic review aimed to address the following focused question: "Is photodynamic therapy effective in the management of oral leukoplakia?'' PubMed/Medline, EMBASE, ISI Web of Knowledge, OVID, CNKI, and WANFANG DATA were searched up to and including June 2018 using different combinations of the following keywords: photodynamic therapy, leukoplakia, oral dysplasia, oral precancers, and oral premalignant lesions...
October 31, 2018: Photodiagnosis and Photodynamic Therapy
Megumi Ichikawa, Jiro Akimoto, Yuichi Miki, Jun Maeda, Tsutomu Takahashi, Yasuyuki Fujiwara, Michihiro Kohno
OBJECTIVE: To investigate the effect of photodynamic therapy (PDT) with the talaporfin sodium (mono-L-asparthyl chlorine e6: NPe-6) on human malignant meningioma cell line HKBMM cells in vitro. MATERIAL AND METHODS: After incubation with NPe6 for 4 hr, cells underwent PDT (diode laser irradiation: 3.4 mW/cm2 and 1 J/cm2 . Cell viability was determined in 2 malignant meningioma cell lines (human origin; HKBMM cells and rat origin; KMY-J cells) and human malignant glioma U251 cells with Cell Counting Kit-8 assay...
October 30, 2018: Photodiagnosis and Photodynamic Therapy
Samireh Badrigilan, Behrouz Shaabani, Nahideh Gharehaghaji, Asghar Mesbahi
BACKGROUND: the all-in-one nanoprobes (NPs) have drawn biomedical attention in the cancer therapy field due to simultaneously combine the capabilities of the therapeutic and diagnostic methods into single nanoprobe. METHOD: in this study, we developed theranostic probe based on superparamagnetic iron oxide (SPIO) and bismuth oxide (Bi2 O3 ) with graphene quantum dots (GQDs) coating to investigate the physical properties for in vitro CT/MR dual-modal biomedical imaging and cancer-specific photothermal therapy (PTT)...
October 29, 2018: Photodiagnosis and Photodynamic Therapy
Kunpeng Wang, Zijian Zhang, Kai Liu, Xin Yang, Heng Zou, Jiangjiao Zhou, Xiongying Miao, Wei Chen, Li Xiong, Yu Wen
BACKGROUND: Inflammatory bowel disease (IBD) is a group of inflammatory conditions characterized by chronic inflammation of the gastrointestinal (GI) tract. Recent preclinical and clinical studies have shown the therapeutic value of photodynamic therapy with low doses of photosensitizer and/or light in colitis treatment, but the detailed mechanism is unclear. METHODS: We examined 5-aminolevulinic acid (5-ALA) mediated photodynamic therapy (PDT) in dextran sulfate sodium (DSS)-induced colitis in mice...
October 29, 2018: Photodiagnosis and Photodynamic Therapy
Emese Gellén, Eszter Fidrus, Margit Péter, Andrea Szegedi, Gabriella Emri, Éva Remenyik
The use of photodynamic therapy is extensive, due to its antitumoral, antibacterial and photorejuvenation effects. It destroys tumor via direct cell destruction and indirectly via vascular shutdown, induction of acute local inflammatory response and activation of the immune system. Both innate and adaptive immune cells are involved in the immunological effects of photodynamic therapy. In addition to UV-induced DNA damage, inflammation and immunosuppression are also essential elements in the pathogenesis of actinic keratosis...
October 28, 2018: Photodiagnosis and Photodynamic Therapy
Limin Liu, Chunmei Hu, Lei Chen, Yuedong Hu
The purpose of this study is to describe the effects and complications of photodynamic therapy (PDT) on Chinese patients with circumscribed choroidal hemangioma (CCH). In this retrospective study, 22 CCH patients who underwent PDT performed 15 min after the injection of intravenous verteporfin (6 mg/m2)with multiple 83-second laser spots at 689 nm (50 J/cm2) were studied. Fluorescein angiography and/or indocyanine green angiography, B-scan ultrasonography and optical coherence tomography were performed in all patients...
October 28, 2018: Photodiagnosis and Photodynamic Therapy
Teerasak Damrongrungruang, Nuaefah Kitchindaopat, Patreeya Thanasothon, Kriravee Theeranut, Patcharaporn Tippayawat, Chaiyapong Ruangsuwan, Banyong Suwannee
BACKGROUND: We aimed to investigate the effect of azulene on peripheral blood mononuclear cells (PBMCs) viability and singlet oxygen formation. METHODS: 1 × 105 PBMCs were cultured in a 96-well plate in RPMI-1640 supplemented with 10% FBS (37 °C, 5% CO2 ) for 24 hours. Each well was treated for 30 minutes with each azulene concentration between 0-500 µM and activated by a 625 ± 5 nm light emitting diode (power 20-23 mW) at energy densities of 0-200 J/cm2 ...
October 28, 2018: Photodiagnosis and Photodynamic Therapy
Saranjam Khan, Rahat Ullah, Shaheen Shahzad, Nasira Anbreen, Muhammad Bilal, Asifullah Khan
We presents the effectiveness of Raman spectroscopy (RS) in combination with machine learning for screening and analysis of blood sera collected from tuberculosis patients. Blood samples of 60 patients have confirmed active pulmonary tuberculosis and 14 samples of healthy age matched control were used in the current study. Spectra from entire sera samples were acquired using 785 nm laser Raman system. Support Vector Machine (SVM) together with Principal Component Analysis (PCA) has been used for highlighting variations spectral intensities between healthy and pathological samples...
October 22, 2018: Photodiagnosis and Photodynamic Therapy
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