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Photodiagnosis and Photodynamic Therapy

Leili Beytollahi, Maryam Pourhajibagher, Nasim Chiniforush, Roghayeh Ghorbanzadeh, Reza Raoofian, Babak Pourakbari, Bahador Abbas
BACKGROUND: The alternative antibacterial treatments of photodynamic therapy (PDT) and photothermal therapy (PTT) significantly affect microbiota inactivation. The aim of the present research was the assessment of the antimicrobial and anti-biofilm effects of PDT with toluidine blue O (TBO) and PTT with indocyanine green (ICG) on Streptococcus mutans as a cariogenic bacterium. MATERIALS AND METHODS: The S. mutans ATCC 35668 strain was treated with final concentrations of 0...
October 18, 2016: Photodiagnosis and Photodynamic Therapy
Milene N O Moritz, Joyce L S Gonçalves, Irwin A P Linares, Janice R Perussi, Kleber T de Oliveira
An amphiphilic chlorin derivative (CHL-T) was prepared from methylpheophorbide a (CHL) and 2-Amino-2-(hydroxymethyl)-1,3-propanediol (TRISMA(®)). The new chlorin was compared to other dyes (CHL and Hypericin) in relation to photophysical and photobiological activities in tumor and non-tumor cell lines. Cytotoxicity and cell death target were determined to evaluate the CHL-T efficiency, comparing to the precursor CHL and to the well-known dye hypericin (HY). All of the studied compounds exhibited absorption bands in the therapeutic window and presented a small fluorescence quantum yield compared to the reference dye (rhodamine B)...
October 18, 2016: Photodiagnosis and Photodynamic Therapy
Yuedong Hu, Liu Ningning, Yanyan Chen
We report a case of tamoxifen associated macular hole with typical optical imaging and clinical features. A 53-year-old woman came to our department for gradual decrees of vision acuity in both eyes for 3 months after 30 months low-dosage-tamoxifen treatment as adjuvant treatment for invasive ductal breast carcinoma. Her best corrected visual acuity (BCVA) was 0.4 in the right eye and 0.12 in the left eye. Dilated fundus examination showed macular multiple, fine, crystalline deposits and small white points in retina of both eyes...
October 13, 2016: Photodiagnosis and Photodynamic Therapy
Maryam Pourhajibagher, Nasim Chiniforush, Roghayeh Ghorbanzadeh, Abbas Bahador
BACKGROUND: Photo-activated disinfection (PAD) is a novel treatment approach, in which bacteria in the root canal system may be exposed to sub-lethal doses of PAD. Such exposure can affect bacterial survival and virulence features, such as biofilm formation ability. The aim of this study was to evaluate the effects of sub-lethal doses of PAD (sPAD) using indocyanine green (ICG) on load and biofilm formation ability of Porphyromonas gingivalis as an anaerobic bacterium associated with endodontic infection...
October 12, 2016: Photodiagnosis and Photodynamic Therapy
Jianfeng Yang, Hongzhang Shen, Hangbin Jin, Qifeng Lou, Xiaofeng Zhang
BACKGROUND: The available evidence of Photodynamic therapy (PDT) combined with stent placement treatment for unresectable extrahepatic cholangiocarcinoma (EHCC) is still insufficient. It remains unclear whether PDT promoting systemic inflammatory response. AIM: To explore the clinical efficacy and safety of the combination treatment and the systemic inflammatory response in patients with EHCC. METHODS: Patients with unresectable EHCC underwent either the combined treatment using Hematoporphyrin PDT and stent placement (PDT+stent group, n=12) or stent-only (stent group, n=27)...
October 5, 2016: Photodiagnosis and Photodynamic Therapy
Farzaneh Ghorbani, Neda Attaran-Kakhki, Ameneh Sazgarnia
BACKGROUND: Photodynamic therapy (PDT) and photothermal therapy (PTT) are two known optical remedies of cancer. PTT can be combined with other therapies. One of the limitations of optical therapies is the penetration of light into biological tissues, which reduces its effectiveness due to usage of photosensitizers and PTT agents, which are absorbed in the NIR region that provides the maximum penetration. For instance, Indocyanine green (ICG) serves as a photosensitizer and Gold nanostructures as agents for PTT...
October 5, 2016: Photodiagnosis and Photodynamic Therapy
Maryam Pourhajibagher, Abbas Bahador
BACKGROUND: Periodontitis is a polymicrobial, chronic, and degenerative disease that can lead to destruction of the teeth-supporting tissues and eventually to loss of teeth. Aggregatibacter actinomycetemcomitans is predominantly associated with periodontal diseases. Outer membrane protein (Omp) 100 is a more important virulence factor of A. actinomycetemcomitans due to the effect of adhesion and invasion into human gingival epithelial cells. Attachment of A. actinomycetemcomitans inhibition is significant in the treatment process...
September 30, 2016: Photodiagnosis and Photodynamic Therapy
Amuthachelvi Daniel, Leena Joseph
Raman spectroscopy and mapping are capable of probing the molecular changes due to oncogenesis. Here Raman maps of cervical tissues under different pathological conditions were studied. Multivariate analytical methods were utilized to reconstruct these Raman maps and were compared with Hematoxylin and Eosin stained histological images. The maps showed clear differences between the different regions of the tissue and there were spectral changes associated with neoplasia and malignancy. A semi-quantitative biochemical modeling was carried out to quantify these spectral changes and the relative contributions of the biochemicals...
September 23, 2016: Photodiagnosis and Photodynamic Therapy
E V Filonenko, A D Kaprin, B Y A Alekseev, O I Apolikhin, E K Slovokhodov, V I Ivanova-Radkevich, A N Urlova
The results of multicenter prospective trial for efficacy of combined modality treatment: transurethral resection (TUR) + photodynamic therapy (PDT) with alasens for bladder cancer are represented in the article. Trials were organized by Research Institute of Organic Intermediates and Dyes and conducted according to clinical protocol approved by Ministry of Health of Russia, at the sites of leading Russian cancer clinical centers. The trial included 45 subjects with verified diagnosis of non-muscle-invasive bladder cancer...
September 23, 2016: Photodiagnosis and Photodynamic Therapy
Yide Huang, Huizhen Yu, Huafei Lv, Hong Zhang, Dongdong Ma, Hongqin Yang, Shusen Xie, Yiru Peng
A novel series of nanoparticles formed via an electrostatic interaction between the periphery of negatively charged 1-2 generation aryl benzyl ether dendrimer zinc (II) phthalocyanines and positively charged poly(L-lysin) segment of triblock copolymer, poly(L-lysin)-block-poly(ethylene glycol)-block-poly(L-lysin), was developed for the use as an effective photosensitizers in photodynamic therapy. The dynamic light scattering, atomic force microscopy showed that two nanoparticles has a relevant size of 80-150nm...
September 23, 2016: Photodiagnosis and Photodynamic Therapy
María Jesús Suárez Valladares, Manuel Ángel Rodríguez Prieto, Ricard Serra Llusà
Photodynamic therapy is a common treatment in dermatology for several diseases, its main limitation is the penetration of photosensitizer and light in the tissue. However intralesional photodynamic therapy is a new technique where the photosensitizer and sometimes a 630nm laser beam are applied inside the lesión, so it allows achieve deeper penetration. It has been used to treat basal cell carcinoma, hidradenitis suppurativa or keloids.
September 16, 2016: Photodiagnosis and Photodynamic Therapy
Nasim Chiniforush, Maryam Pourhajibagher, Steven Parker, Sima Shahabi, Abbas Bahador
INTRODUCTION: The purpose of this study was to evaluate the in vitro effect of washing and non-washing of indocyanine green (ICG) as photosensitizer (PS) on bacterial count, biofilm formation, development and degradation of Enterococcus faecalis. METHODS: The anti-bacterial, anti-biofilm formation, anti-biofilm development and biofilm degradation of anti-microbial photodynamic therapy (aPDT) against E. faecalis was determined at concentrations of 3 to 2000μg/mL of ICG, subject to 18J/cm(2) dose of diode laser (808nm) in washing and non-washing producers...
September 15, 2016: Photodiagnosis and Photodynamic Therapy
Maryam Pourhajibagher, Nasim Chiniforush, Reza Raoofian, Babak Pourakbari, Roghayeh Ghorbanzadeh, Farzaneh Bazarjani, Abbas Bahador
BACKGROUND: Eradication or suppression of microbial pathogens is a major goal in endodontic infection therapy. Sub-lethal doses of photo-activated disinfection (sPAD) as a new treatment method would be able to the microorganisms involved in endodontic infections normally treated with PAD. This study evaluated the effect of sPAD using methylene blue (MB) in combination with diode laser irradiation on the growth and biofilm formation ability of Porphyromonas gingivalis as an endodontic pathogen...
September 14, 2016: Photodiagnosis and Photodynamic Therapy
Lautaro Gándara, Leandro Mamone, Cristian Dotto, Fernanda Buzzola, Adriana Casas
Photodynamic inactivation (PDI) involves the combined use of light and a photosensitizer, which, in the presence of oxygen, originates cytotoxic species capable of inactivating bacteria. Since the emergence of multi-resistant bacterial strains is becoming an increasing public health concern, PDI becomes an attractive choice. The aim of this work was to study the differential susceptibility to Toluidine blue (TB) mediated PDI (TB-PDI) of S. aureus mutants (RN6390 and Newman backgrounds) for different key regulators of virulence factors related to some extent to oxidative stress...
September 9, 2016: Photodiagnosis and Photodynamic Therapy
Zohaib Akram, Tariq Abduljabbar, Salvatore Sauro, Umer Daood
BACKGROUND: To assess the efficacy of antimicrobial photodynamic therapy (aPDT) or laser therapy (LT) alone as an adjunct to scaling and root planing (SRP) on the gingival crevicular fluid (GCF) inflammatory proteins in periodontal disease. METHODS: Databases (MEDLINE via PubMed; EMBASE; Cochrane Central Register of Controlled Trials and Cochrane Oral Health Group Trials Register databases) were searched from 1980 up to and including July 2016. The addressed PICO question was: "What effect does aPDT and/or LT as an adjunct to SRP have on the GCF inflammatory proteins in periodontal disease patients?" RESULTS: Eight studies used aPDT while 10 studies used laser alone...
September 9, 2016: Photodiagnosis and Photodynamic Therapy
José D Vollet Filho, Cintia T Andrade, Hilde H Buzza, Kate Blanco, Fernanda Carbinatto, Vanderlei S Bagnato, Ron R Allison
Aktinic Keratosis is common and if left untreated may develop into life threatening squamous cell carcinoma. Therefore early intervention is the standard of care. While many treatments are available PDT continues to move to the for - front for this indication (Brito et al., 2016 [31]). Topical PS is commercially available that are able to reliably ablate these lesions. Innovative protocols including sunlight, large volume LED arrays and maneuvers to improve treatment parameters and cosmesis continue to make this a worldwide treatment of choice for AK...
September 7, 2016: Photodiagnosis and Photodynamic Therapy
Leonardo Pereira Franch, Camila F Amantino, Maryanne T Melo, Ana Paula de Lima Montaldi, Fernando L Primo, Antonio Claudio Tedesco
BACKGROUND: The photodynamic therapy (PDT) has been used to treat cancer mainly by inducing oxidative stress. Our aim was to evaluate the effect of PDT and its combination with methoxyamine (MX), a blocker of base excision repair (BER), in cells expressing high levels of the APE1 protein, which is involved in cell oxidative damage response. METHODS: The HeLa and A549 cells were treated for 3h with chloroaluminum phthalocyanine incorporated into a well-designed nanoemulsion (ClAlPc/NE); and then irradiated by visible light (@670nm) with doses of 0...
September 6, 2016: Photodiagnosis and Photodynamic Therapy
Sergio Varela Kellesarian, Vanessa Ros Malignaggi, Tariq Abduljabbar, Fahim Vohra, Hans Malmstrom, Georgios E Romanos, Fawad Javed
BACKGROUND: the aim of the present review was to study the efficacy of scaling and root planing (SRP) with and without adjunct antibacterial photodynamic therapy (aPDT) on the expression of cytokines in the gingival crevicular fluid (GCF) of patients with periodontitis. METHODS: In order to address the focused question: "What is the efficacy of SRP with and without aPDT on the expression of cytokines in the GCF of patients with periodontitis" an electronic search without time or language restrictions was conducted up to and including July 2016 in indexed databases using various key words...
September 5, 2016: Photodiagnosis and Photodynamic Therapy
Fawad Javed, Tariq Abduljabbar, Gabriela Carranza, Elham Gholamiazizi, David K Mazgaj, Sergio Varela Kellesarian, Fahim Vohra
OBJECTIVE: The aim was to assess the efficacy of mechanical debridement (MD) with and without adjunct antimicrobial photodynamic therapy (aPDT) in reducing periimplant inflammation among cigarette-smokers and non-smokers. METHODS: Cigarette-smokers and non-smokers were randomly divided into 2 groups. In the test-group, participants underwent full mouth scaling and periimplant MD with adjunct aPDT; and in the control-group, the participants underwent full mouth scaling and periimplant MD alone...
September 3, 2016: Photodiagnosis and Photodynamic Therapy
Camille Munck, Serge Mordon, Nacim Betrouni
BACKGROUND: Complete and homogeneous illumination of the pleural cavity is essential to the success of photodynamic therapy (PDT) for mesothelioma, but remains a challenge. Knowing the repartition and propagation of light around the light applicator could be the first step towards optimizing dosimetry. Here we propose a characterization method of the illumination profile of a specific light device. METHODS: The light wand, made of a cylindrical diffuser located inside an endotracheal tube, was fixed in a tank filled with dilute 0...
September 1, 2016: Photodiagnosis and Photodynamic Therapy
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