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Photodiagnosis and Photodynamic Therapy

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https://www.readbyqxmd.com/read/27919664/photodynamic-therapy-with-green-light-for-the-treatment-of-vulvar-lichen-sclerosus-preliminary-results
#1
B J Osiecka, K Jurczyszyn, P Nockowski, M Murawski, P Ziółkowski
INTRODUCTION: The standard treatment for lichen sclerosus (LS) is symptomatic and is primarily based on the chronic use of corticosteroids, sometimes resulting in unsatisfactory effects. Therefore, other non-pharmacological methods are being sought, which are less aggravating for the patient. LS can be treated topically by using photodynamic therapy (PDT) based on 5-aminolevulinic acid (5-ALA). Unfortunately, therapy with the red light is often connected with severe local pain during the illumination...
December 2, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27919663/efficacy-of-low-level-laser-therapy-in-the-treatment-of-burning-mouth-syndrome-a-systematic-review
#2
REVIEW
Sadeq Ali Al-Maweri, Fawad Javed, Butchibabu Kalakonda, Nader A AlAizari, Walid Al-Soneidar, Ameen Al-Akwa
BACKGROUND: Burning mouth syndrome (BMS) is a chronic pain condition with indefinite cure, predominantly affecting post-menopausal women. The aim of this study was to systematically review the efficacy of low level laser therapy in the treatment of burning mouth syndrome (BMS). METHODS: PubMed, Embase and Scopus were searched from date of inception till and including October 2016 using various combinations of the following keywords: burning mouth syndrome, BMS, stomatodynia, laser therapy, laser treatment and phototherapy...
December 2, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27902926/dental-bleaching-with-the-use-of-violet-light-only-reality-or-future
#3
Andréa Dias Neves Lago, Winnie Dandara Rocha Ferreira, Guilherme Silva Furtado
No abstract text is available yet for this article.
November 27, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27903435/lack-of-effect-of-selected-sunscreens-applied-on-ex-vivo-human-skin-for-5-methyl-aminolevulinic-acid-penetration-and-protoporphyrin-ix-photoactivation
#4
Hanan Osman-Ponchet, Karine Sevin, Alexandre Gaborit, Magali Kouidhi, Johanna Hanaizi, Pierre Comby, Bernard Ruty, Guy Bouvier
BACKGROUND: Photodynamic therapy (PDT) is a successful treatment for non-melanoma skin cancers. Methyl-aminolevulinate (MAL) is metabolized to protoporphyrin IX (PpIX) which accumulates in the skin lesion and which generates a painful photochemical toxic reaction upon red light exposure. PDT using daylight (DL) exposure is now used to reduce pain and subjects are advised to protect the areas with sunscreen. This work investigated the effect of sunscreen on MAL penetration and PpIX photoactivation in ex vivo human skin...
November 26, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27890593/evaluation-of-the-crystal-structure-of-a-fimbrillin-fima-from-porphyromonas-gingivalis-as-a-therapeutic-target-for-photo-activated-disinfection-with-toluidine-blue-o
#5
Maryam Pourhajibagher, Abbas Bahador
BACKGROUND: Porphyromonas gingivalis is one of the etiological agents in the initiation of combined periodontal-endodontic (perio-endo) lesions. Successful treatment of perio-endo lesions with photo-activated disinfection (PAD) as a novel therapeutic approach depends on the selection of an appropriate target site, specific photosensitizer (PS), and wavelength of light. Since the fimbrillin (FimA) is the most important pathogenic agent in P. gingivalis it was evaluated as a target site against PAD with toluidine blue O (TBO) as a PS...
November 23, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27888165/clinical-effectiveness-of-adjunctive-antimicrobial-photodynamic-therapy-for-residual-pockets-during-supportive-periodontal-therapy-a-systematic-review-and-meta-analysis
#6
Dong Xue, Ying Zhao
PURPOSE: To evaluate the clinical efficacy of antimicrobial photodynamic therapy (aPDT) adjunctive to scaling and root planing (SRP) in the treatment of residual pockets for chronic periodontitis patients on supportive periodontal therapy (SPT). METHOD: Bibliographic databases of MEDLINE and Cochrane Library were thoroughly searched up to July 2016 for eligible randomized controlled trials (RCTs). Mean differences (MD) and the corresponding 95% confidence intervals (CI) were synthesized for probing depth (PD) reduction and clinical attachment level (CAL) gain...
November 22, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27888164/optimizing-zn-porphyrin-based-photosensitizers-for-efficient-antibacterial-photodynamic-therapy
#7
Khazna Alenezi, Artak Tovmasyan, Ines Batinic-Haberle, Ludmil T Benov
INTRODUCTION: Efficient photodynamic inactivation of microbes requires highly efficient photosensitizers which kill microbial cells, but spare host tissues. One way to achieve such selectivity is to use photosensitizers that are rapidly taken up by microbes and, when applied at low concentrations, efficiently kill them after a short illumination. Design of such photosensitizers requires insight into molecular properties which are critical for antimicrobial photo-efficiency. This study explores the contribution of molecular shape and exposure of charges, to the antimicrobial activity of tetra-cationic Zn porphyrin-based photosensitizers...
November 22, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27888163/antimicrobial-photodynamic-therapy-adjuvant-to-non-surgical-periodontal-therapy-in-patients-with-diabetes-mellitus-a-meta-analysis
#8
REVIEW
Tariq Abduljabbar, Fahim Vohra, Fawad Javed, Zohaib Akram
BACKGROUND: To determine whether treatment with antimicrobial photodynamic therapy (aPDT) as an adjunct to scaling and root planing (SRP) improves periodontal clinical and glycemic outcomes in chronic periodontitis patients (CP) with type 2 diabetes mellitus (DM). METHODS: Databases (MEDLINE via PubMed; EMBASE; Cochrane Central Register of Controlled Trials and Cochrane Oral Health Group Trials Register databases) were searched up to and including October 2016. The addressed PICO question was: "What are the effects aPDT as an adjunct to SRP in terms of periodontal and glycemic outcomes as compared to SRP alone in individuals with DM?" RESULTS: Four randomized clinical trials were included in the present review...
November 22, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27888162/photodynamic-therapy-as-an-alternative-treatment-for-relapsed-or-refractory-mycosis-fungoides-a-systemic-review
#9
REVIEW
Jingwen Xue, Cynthia Liu, Yuehua Liu
Mycosis fungoides is the most common cutaneous T-cell lymphoma. It is characterized by slow progress over years to decades, developing from patches to infiltrated plaques, and sometimes to tumors. Therapies such as localized chemotherapy, photochemotherapy and radiotherapy are often employed when lesions of refractory or relapsing mycosis fungoides are resistant to conventional therapies. However, these methods have acute or chronic side effects and toxicity, which may accumulate with repeated and protracted treatment cycles...
November 22, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27888161/sensitization-of-immune-cells-following-hexylaminolevulinate-photodynamic-therapy-of-cervical-intraepithelial-neoplasia
#10
Ralf Hass, Roland Jacobs, Andreas M Kaufmann, Peter Hillemanns, Philipp Soergel
BACKGROUND: Effects of photodynamic therapy (PDT) were tested with respect to immune cell stimulation in cervical intraepithelial neoplasia (CIN). METHODS: A patient with CIN received hexaminolevulinate (HAL) and subsequent PDT. These data were compared to a placebo PDT patient and a healthy HPV16-vaccinated donor. Isolation of peripheral blood mononuclear cells (PBMC) was performed before PDT and at 4 different time points after PDT. The proliferation of these PBMC was tested by [(3)H]thymidine incorporation following stimulation with control or HPV16-L1 peptides...
November 22, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27888160/preliminary-results-of-comparative-study-for-subsequent-photodynamic-therapy-versus-secondary-excision-after-primary-excision-for-treating-basal-cell-carcinoma
#11
Wenbo Bu, Mengli Zhang, Qian Zhang, Chunyu Yuan, Xu Chen, Fang Fang
Some basal cell carcinomas (BCCs) are indistinguishable from nevi based on clinical manifestations. Therefore, it is often difficult for the excision margins of the initial surgical treatment to achieve radical removal of the malignancy. This study was a comparative analysis of the clinical results of aminolevulinic acid (ALA)-photodynamic therapy (PDT) or secondary surgery after the primary excision. In total, 20 patients with preoperative clinical diagnoses of nevi underwent in situ resection. The postoperative pathological diagnoses confirmed all cases were BCC...
November 22, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27884740/effect-of-mechanical-debridement-with-adjunct-antimicrobial-photodynamic-therapy-in-the-treatment-of-peri-implant-diseases-in-type-2-diabetic-smokers-and-non-smokers
#12
Tariq Abduljabbar
OBJECTIVE: The aim of the present 6-month follow-up study was to assess the effect of mechanical debridement (MD) with adjunct antimicrobial photodynamic therapy (aPDT) in the treatment of peri-implant diseases in type-2 diabetic smokers and non-smokers. METHODS: Patients were divided into 2 groups: (a) Group-1: type-2 diabetic smokers; and (b) Group-2: type-2 diabetic non-smokers. In both groups, hemoglobin A1c (HbA1c) levels and peri-implant bleeding on probing (BOP) and probing depth (PD) ≥4mm were measured at baseline and after 6 months of follow-up...
November 21, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27866000/effectiveness-of-final-decontamination-protocols-against-enterococcus-faecalis-and-its-influence-on-bond-strength-of-filling-material-to-root-canal-dentin
#13
Matheus Albino Souza, Daniel Dalla Lana, Ezequiel Gabrielli, Marlos Barbosa Ribeiro, Daniela Cristina Miyagaki, Doglas Cecchin
AIM: The aim of this study was to evaluate the effectiveness of final decontamination protocols against Enterococcus faecalis and their influence on bond strength of filling material to root canal dentin. MATERIAL AND METHODS: Ninety root canals were enlarged with ProTaper system and inoculated with E. faecalis for 15 days. Sixty samples were randomly divided into six groups (n=10) and subjected to following protocols: G1-distilled water(control), G2-2% chlorhexidine, G3-QMix, G4-6...
November 16, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27840177/fluorescence-intensity-and-bright-spot-analyses-using-a-confocal-microscope-for-photodynamic-diagnosis-of-brain-tumors
#14
Takeshi Yoneyama, Tetsuyo Watanabe, Hiroyuki Kagawa, Yutaka Hayashi, Mitsutoshi Nakada
BACKGROUND: In photodynamic diagnosis using 5-aminolevulinic acid (5-ALA), discrimination between the tumor and normal tissue is very important for a precise resection. However, it is difficult to distinguish between infiltrating tumor and normal regions in the boundary area. In this study, fluorescent intensity and bright spot analyses using a confocal microscope is proposed for the precise discrimination between infiltrating tumor and normal regions. METHODS: From the 5-ALA-resected brain tumor tissue, the red fluorescent and marginal regions were sliced for observation under a confocal microscope...
November 10, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27825899/influence-of-culture-conditions-on-porphyrin-production-in-aggregatibacter-actinomycetemcomitans-and-porphyromonas-gingivalis
#15
Jonas Fyrestam, Nadja Bjurshammar, Elin Paulsson, Nesrine Mansouri, Annsofi Johannsen, Conny Östman
BACKGROUND: Increasing antibiotic resistance among pathogens has raised the demands for new treatment methods such as antimicrobial photodynamic therapy (aPDT) and phototherapy (PT). Experiments for investigating the effects of these methods are often performed in vitro, but the procedures for cultivation of microbes vary between different studies. The aim of this study has been to elucidate how the profile of endogenously produced porphyrins differs by changing the variables of bacteria culturing conditions...
November 4, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27816623/antimicrobial-photodynamic-therapy-using-indocyanine-green-and-near-infrared-diode-laser-in-reducing-entrerococcus-faecalis
#16
Charis Beltes, Hercules Sakkas, Nikolaos Economides, Chrissanthy Papadopoulou
BACKGROUND: The use of Antimicrobial Photodynamic Therapy (aPDT) has been suggested as an adjuvant method to eliminate facultative bacteria during root canal disinfection. The purpose of this preliminary in vitro study was to determine whether the light-activated antimicrobial agent, Indocyanine green (ICG), could be used as photosensitizer and kill Enterococcus faecalis strain under planktonic conditions when irradiated with near-infared (NIR) diode laser emitting in 810nm wavelength...
November 2, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27777144/over-expression-of-5-aminolevulinic-acid-synthase-2-increased-protoporphyrin-%C3%A2-in-nonerythroid-cells
#17
Hui Huang, Wei Wang, Jiaqi Zou, Osamu Nakajima, Lei Zhang, Qi He, Yan Diao, Huan Liang, Lingyun Zhou, Yahui Peng
Protoporphyrin Ⅸ has been used as an efficient sensitizer in photodynamic diagnose, photodynamic therapy, and sonodynamic therapy. The level of protoporphyrin Ⅸ is very important for diagnose or therapy effects. 5-aminolevulinic acid synthase 2 (ALAS2) is the key enzyme upstream of protoporphyrin Ⅸ synthesis. To increase protoporphyrin Ⅸ accumulation, ALAS2 over-expression transgenic mice were generated. Plasmid containing alas2 gene was transfected in colonic carcinoma cell lines. Both in tissues of transgenic mice and in colonic carcinoma cells, the amount of protoporphyrin Ⅸ accumulation did increase...
October 21, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27777143/the-influence-of-photodynamic-therapy-with-5-aminolevulinic-acid-on-senescent-skin-cancer-cells
#18
Mantas Grigalavicius, Marina Juraleviciute, Mateusz Kwitniewski, A Juzeniene
BACKGROUND: Senescent cells, which are resistant to apoptosis, accumulate with age and after ultraviolet (UV) radiation, chemotherapy and radiation therapy. Preventing or eliminating senescent cells may be crucial for protection against skin cancer development and improving tumour treatment. The aim of the present study was to investigate the potential of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) to induce senescence in skin cancer cells and to eliminate senescent cells induced by chemotherapy (bleomycin) or UVA (315-400nm) exposure...
October 21, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27769914/the-efficacy-of-photodynamic-and-photothermal-therapy-on-biofilm-formation-of-streptococcus-mutans-an-in-vitro-study
#19
Leili Beytollahi, Maryam Pourhajibagher, Nasim Chiniforush, Roghayeh Ghorbanzadeh, Reza Raoofian, Babak Pourakbari, Bahador Abbas
BACKGROUND: The alternative antibacterial treatments of photodynamic therapy (PDT) and photothermal therapy (PTT) significantly affect microbiota inactivation. The aim of the present research was the assessment of the antimicrobial and anti-biofilm effects of PDT with toluidine blue O (TBO) and PTT with indocyanine green (ICG) on Streptococcus mutans as a cariogenic bacterium. MATERIALS AND METHODS: The S. mutans ATCC 35668 strain was treated with final concentrations of 0...
October 18, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27769913/semi-synthesis-and-pdt-activities-of-a-new-amphiphilic-chlorin-derivative
#20
Milene N O Moritz, Joyce L S Gonçalves, Irwin A P Linares, Janice R Perussi, Kleber T de Oliveira
An amphiphilic chlorin derivative (CHL-T) was prepared from methylpheophorbide a (CHL) and 2-Amino-2-(hydroxymethyl)-1,3-propanediol (TRISMA(®)). The new chlorin was compared to other dyes (CHL and Hypericin) in relation to photophysical and photobiological activities in tumor and non-tumor cell lines. Cytotoxicity and cell death target were determined to evaluate the CHL-T efficiency, comparing to the precursor CHL and to the well-known dye hypericin (HY). All of the studied compounds exhibited absorption bands in the therapeutic window and presented a small fluorescence quantum yield compared to the reference dye (rhodamine B)...
October 18, 2016: Photodiagnosis and Photodynamic Therapy
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