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Expert Review of Proteomics

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https://www.readbyqxmd.com/read/28532233/updates-on-sj%C3%A3-gren-s-syndrome-from-proteomics-to-protein-biomarkers
#1
Chiara Baldini, Antonella Cecchettini, Alessia Gallo, Stefano Bombardieri
Primary Sjögren's syndrome (pSS) is a complex heterogeneous autoimmune disorder, typically affecting exocrine glands. Recently, a great interest has arisen in searching for novel biomarkers able to improve the diagnostic work-up of the disease as well as the general assessment and the prognostic stratification of pSS patients. From this perspective, salivary proteomics has appeared as a promising tool considering that salivary proteins may closely reflect the underlying disease processes in the salivary glands...
May 23, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28532181/exploring-ribosome-composition-and-newly-synthesized-proteins-through-proteomics-and-potential-biomedical-applications
#2
Miroslava Stastna, Roberta A Gottlieb, Jennifer E Van Eyk
Protein synthesis is the outcome of tightly regulated gene expression which is responsive to a variety of conditions. Efforts are ongoing to monitor individual stages of protein synthesis to ensure maximum efficiency and accuracy. Due to post-transcriptional regulation mechanisms, the correlation between translatome and proteome is higher than between transcriptome and proteome. However, the most accurate approach to assess the key modulators and final protein expression is directly by using proteomics. Areas covered: This review covers various proteomic strategies that were used to better understand post-transcriptional regulation, specifically during and early after translation...
May 22, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28524784/how-do-we-improve-treatments-for-patients-with-amyloidosis-using-proteomics
#3
Francesca Lavatelli, Giampaolo Merlini
No abstract text is available yet for this article.
May 19, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28521569/exploring-the-biochemistry-of-the-prenylome-and-its-role-in-disease-through-proteomics-progress-and-potential
#4
Maura Brioschi, Alma Martinez Fernandez, Cristina Banfi
Protein prenylation is a ubiquitous covalent post-translational modification characterized by the addition of farnesyl or geranylgeranyl isoprenoid groups to a cysteine residue located near the carboxyl terminal of a protein. It is essential for the proper localization and cellular activity of numerous proteins, including Ras family GTPases and G-proteins. In addition to its roles in cellular physiology, the prenylation process has important implications in human diseases and in the recent years, it has become attractive target of inhibitors with therapeutic potential...
May 18, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28513226/application-of-proteomics-to-the-study-of-helicobacter-pylori-and-implications-for-the-clinic
#5
Giulia Bernardini, Natale Figura, Antonio Ponzetto, Barbara Marzocchi, Annalisa Santucci
Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the gastric epithelium and mucous layer of more than half the world's population. H. pylori is a primary human pathogen, responsible for the development of chronic gastritis, peptic ulceration and gastric cancer. Proteomics is impacting several aspects of medical research: understanding the molecular basis of infection and disease manifestation, identification of therapeutic targets and discovery of clinically relevant biomarkers. Areas covered: The main aim of the present review is to provide a comprehensive overview of the contribution of proteomics to the study of H...
May 17, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28448729/proteomics-of-blood-plasma-serum-samples-stored-in-biobanks-insights-for-clinical-application
#6
Jean-Daniel Tissot, Christine Currat, Dominique Sprumont
No abstract text is available yet for this article.
May 9, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28438056/mass-spectrometry-analysis-for-amyloidosis-typing-is-the-future-bright-for-its-clinical-implementation
#7
Michelle M Hill, Peter N Mollee
No abstract text is available yet for this article.
May 3, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28388239/can-protein-science-solve-the-unmet-needs-in-pancreatic-cancer-diagnosis-and-therapy
#8
Daniel Ansari, Fredrik Sambergs, Love Johansson, Roland Andersson
No abstract text is available yet for this article.
April 7, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28335651/from-mystery-to-mechanism-can-proteomics-build-systems-level-understanding-of-our-gut-microbes
#9
Carlos G Gonzalez, Lichao Zhang, Joshua E Elias
No abstract text is available yet for this article.
March 24, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28281838/diagnostic-function-of-the-neuroinflammatory-biomarker-ykl-40-in-alzheimer-s-disease-and-other-neurodegenerative-diseases
#10
Filippo Baldacci, Simone Lista, Enrica Cavedo, Ubaldo Bonuccelli, Harald Hampel
Neuroinflammation is a crucial mechanism in the pathophysiology of neurodegenerative diseases pathophysiology. Cerebrospinal fluid (CSF) YKL-40 - an indicator of microglial activation - has recently been identified by proteomic studies as a candidate biomarker for Alzheimer's disease (AD). Areas covered: We review the impact of CSF YKL-40 as a pathophysiological biomarker for AD and other neurodegenerative diseases. CSF YKL-40 concentrations have been shown to predict progression from prodromal mild cognitive impairment to AD dementia...
March 20, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28271922/prion-like-proteins-and-their-computational-identification-in-proteomes
#11
Cristina Batlle, Valentin Iglesias, Susanna Navarro, Salvador Ventura
The aberrant or misfolded forms of the prion protein have been described as the causative agents of rare transmissible spongiform encephalopathies. In addition, proteins associated with frequently occurring neurodegenerative disorders, such as Alzheimer's and Parkinson's, are shown to share prion-like properties and to spread the disease in the brain. Areas covered: Interest in the prion phenomenon has crystallized in a series of computational methods aimed at uncovering prion-like proteins at the proteome level...
March 20, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28271739/role-of-the-microtubule-associated-tppp-p25-in-parkinson-s-and-related-diseases-and-its-therapeutic-potential
#12
Judit Oláh, Philippe Bertrand, Judit Ovádi
The discovery and development of therapeutic strategies for the treatments of Parkinson's disease (PD) and other synucleinopathies are limited by a lack of understanding of the pathomechanisms and their connection with different diseases such as cancers. Areas covered: The hallmarks of these diseases are frequently multifunctional disordered proteins displaying moonlighting and/or chameleon features, which are challenging drug targets. A representative of these proteins is the disordered Tubulin Polymerization Promoting Protein (TPPP/p25) expressed specifically in oligodendrocytes (OLGs) in normal brain...
March 15, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28271721/the-potential-impact-of-recent-insights-into-proteomic-changes-associated-with-glaucoma
#13
Sebastian Funke, Natarajan Perumal, Katharina Bell, Norbert Pfeiffer, Franz H Grus
Glaucoma, a major ocular neuropathy, is still far from being understood on a molecular scale. Proteomic workflows revealed glaucoma associated alterations in different eye components. By using state-of-the-art mass spectrometric (MS) based discovery approaches large proteome datasets providing important information about glaucoma related proteins and pathways could be generated. Corresponding proteomic information could be retrieved from various ocular sample species derived from glaucoma experimental models or from original human material (e...
March 8, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28276747/proteogenomic-studies-on-cancer-drug-resistance-towards-biomarker-discovery-and-target-identification
#14
Shuyue Fu, Xiang Liu, Maochao Luo, Ke Xie, Edouard C Nice, Haiyuan Zhang, Canhua Huang
Chemoresistance is a major obstacle for current cancer treatment. Proteogenomics is a powerful multi-omics research field that uses customized protein sequence databases generated by genomic and transcriptomic information to identify novel genes (e.g. noncoding, mutation and fusion genes) from mass spectrometry-based proteomic data. By identifying aberrations that are differentially expressed between tumor and normal pairs, this approach can also be applied to validate protein variants in cancer, which may reveal the response to drug treatment...
March 6, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28436239/clinical-applications-of-quantitative-proteomics-using-targeted-and-untargeted-data-independent-acquisition-techniques
#15
Jesse G Meyer, Birgit Schilling
While selected/multiple-reaction monitoring (SRM or MRM) is considered the gold standard for quantitative protein measurement, emerging data-independent acquisition (DIA) using high-resolution scans have opened a new dimension of high-throughput, comprehensive quantitative proteomics. These newer methodologies are particularly well suited for discovery of biomarker candidates from human disease samples, and for investigating and understanding human disease pathways. Areas covered: This article reviews the current state of targeted and untargeted DIA mass spectrometry-based proteomic workflows, including SRM, parallel-reaction monitoring (PRM) and untargeted DIA (e...
May 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28425787/defining-the-proteomic-landscape-of-rheumatoid-arthritis-progress-and-prospective-clinical-applications
#16
Lucía Lourido, Francisco J Blanco, Cristina Ruiz-Romero
The heterogeneity of Rheumatoid Arthritis (RA) and the absence of clinical tests accurate enough to identify the early stages of this disease have hampered its management. Therefore, proteomics research is increasingly focused on the discovery of novel biological markers, which would not only be able make an early diagnosis, but also to gain insight into the different pathological mechanisms underlying the heterogeneity of RA and also to stratify patients, which is critical to enabling effective treatments...
May 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28406322/mass-spectrometry-based-proteomic-exploration-of-the-human-immune-system-focus-on-the-inflammasome-global-protein-secretion-and-t-cells
#17
Tuula A Nyman, Martina B Lorey, Wojciech Cypryk, Sampsa Matikainen
The immune system is our defense system against microbial infections and tissue injury, and understanding how it works in detail is essential for developing drugs for different diseases. Mass spectrometry-based proteomics can provide in-depth information on the molecular mechanisms involved in immune responses. Areas covered: Summarized are the key immunology findings obtained with MS-based proteomics in the past five years, with a focus on inflammasome activation, global protein secretion, mucosal immunology, immunopeptidome and T cells...
May 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28395554/monitoring-proteolytic-processing-events-by-quantitative-mass-spectrometry
#18
Mariel Coradin, Kelly R Karch, Benjamin A Garcia
Protease activity plays a key role in a wide variety of biological processes including gene expression, protein turnover and development. misregulation of these proteins has been associated with many cancer types such as prostate, breast, and skin cancer. thus, the identification of protease substrates will provide key information to understand proteolysis-related pathologies. Areas covered: Proteomics-based methods to investigate proteolysis activity, focusing on substrate identification, protease specificity and their applications in systems biology are reviewed...
May 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28395553/proteomics-and-irritable-bowel-syndrome
#19
Athanasios Tsigaridas, Ioannis S Papanikolaou, Anna Vaiopoulou, Athanasios K Anagnostopoulos, Nikos Viazis, George Karamanolis, Dimitrios G Karamanolis, George T Tsangaris, Gerasimos J Mantzaris, Maria Gazouli
Irritable bowel syndrome (IBS) is a gastrointestinal disease that according to Rome IV criteria is subdivided into four subtypes. The pathophysiology of this disease is not well understood due to numerous factors playing multiple roles in disease development, such as diet, stress and hormones. IBS has a variety of symptoms and overlaps with many other gastrointestinal and non-gastrointestinal diseases. Area covered: This review aims to present an overview of implementation of proteomics in experimental studies in the field of IBS...
May 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28388247/spit-it-out-how-could-the-sputum-proteome-aid-clinical-research-into-pulmonary-diseases
#20
Paolo Iadarola, Simona Viglio
No abstract text is available yet for this article.
May 2017: Expert Review of Proteomics
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