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Expert Review of Proteomics

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https://www.readbyqxmd.com/read/28644690/advances-in-the-development-of-human-protein-microarrays
#1
Jessica Duarte, Jonathan M Blackburn
High-content protein microarrays in principle enable the functional interrogation of the human proteome in a broad range of applications, including biomarker discovery, profiling of immune responses, identification of enzyme substrates, and quantifying protein-small molecule, protein-protein and protein-DNA/RNA interactions. As with other microarrays, the underlying proteomic platforms are under active technological development and a range of different protein microarrays are now commercially available. However, deciphering the differences between these platforms to identify the most suitable protein microarray for the specific research question is not always straightforward...
June 23, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28635376/advances-in-understanding-the-role-of-disease-associated-proteins-in-spinal-muscular-atrophy
#2
Seyyedmohsen Hosseinibarkooie, Svenja Schneider, Brunhilde Wirth
Spinal muscular atrophy (SMA) is a neurodegenerative disorder characterized by alpha motor neuron loss in the spinal cord due to reduced survival of motor neuron (SMN) protein level. While the genetic basis of SMA is well described, the specific molecular pathway underlying SMA is still not fully understood. Areas covered: This review discusses the recent advancements in understanding the molecular pathways in SMA using different omics approaches and genetic modifiers identified in both vertebrate and invertebrate systems...
June 21, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28625086/hepatitis-c-virus-apolipoprotein-interactions-molecular-mechanisms-and-clinical-impact
#3
Emilie Crouchet, Thomas F Baumert, Catherine Schuster
Chronic hepatitis C virus (HCV) infection is a leading cause of cirrhosis, hepatocellular carcinoma and liver failure. Moreover, chronic HCV infection is associated with liver steatosis and metabolic disorders. With 130-150 million people chronically infected in the world, HCV infection represents a major public health problem. One hallmark on the virus is its close link with hepatic lipid and lipoprotein metabolism. Areas covered: HCV is associated with lipoprotein components such as apolipoproteins. These interactions play a key role in the viral life cycle, viral persistence and pathogenesis of liver disease...
June 17, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28621158/signaling-pathway-profiling-using-reverse-phase-protein-array-and-its-clinical-applications
#4
Mari Masuda, Tesshi Yamada
Increased accessibility to next-generation sequencing within the last decade has led to a paradigm shift in cancer treatment from one-size-fits-all medicine to precision medicine providing therapeutic strategies tailored to the requirements of individual patients. However, the effect of even the most successful agent yet tested is only transient, and durable efficacy has yet to be achieved. Genome- and transcriptome-based approaches cannot fully predict the diversity of protein expression patterns or post-translational modifications that directly contribute to cancer pathogenesis and physiology...
June 16, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28586280/a-decade-of-proteomics-accomplished-central-and-eastern-european-proteomic-conference-ceepc-celebrates-its-10th-anniversary-in-budapest-hungary
#5
Suresh Jivan Gadher, László Drahos, Károly Vékey, Hana Kovarova
The Central and Eastern European Proteomic Conference (CEEPC) proudly celebrated its 10th Anniversary with an exciting scientific program inclusive of proteome, proteomics and systems biology in Budapest, Hungary. Since 2007, CEEPC has represented 'state-of the-art' proteomics in and around Central and Eastern Europe and these series of conferences have become a well-recognized event in the proteomic calendar. Fresher challenges and global healthcare issues such as ageing and chronic diseases are driving clinical and scientific research towards regenerative, reparative and personalized medicine...
June 16, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28539064/recent-advances-in-applying-mass-spectrometry-and-systems-biology-to-determine-brain-dynamics
#6
Enzo Scifo, Giulio Calza, Martin Fuhrmann, Rabah Soliymani, Marc Baumann, Maciej Lalowski
Neurological disorders encompass various pathologies which disrupt normal brain physiology and function. Poor understanding of their underlying molecular mechanisms and their societal burden argues for the necessity of novel prevention strategies, early diagnostic techniques and alternative treatment options to reduce the scale of their expected increase. Areas covered: This review scrutinizes mass spectrometry based approaches used to investigate brain dynamics in various conditions, including neurodegenerative and neuropsychiatric disorders...
June 1, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28562112/major-depressive-disorder-insight-into-candidate-cerebrospinal-fluid-protein-biomarkers-from-proteomics-studies
#7
Mhd Rami Al Shweiki, Patrick Oeckl, Petra Steinacker, Bastian Hengerer, Carlos Schönfeldt-Lecuona, Markus Otto
Major Depressive Disorder (MDD) is the leading cause of global disability, and an increasing body of literature suggests different cerebrospinal fluid (CSF) proteins as biomarkers of MDD. The aim of this review is to summarize the suggested CSF biomarkers and to analyze the MDD proteomics studies of CSF and brain tissues for promising biomarker candidates. Areas covered: The review includes the human studies found by a PubMed search using the following terms: "depression cerebrospinal fluid biomarker", "major depression biomarker CSF", "depression CSF biomarker", "proteomics depression", "proteomics biomarkers in depression", "proteomics CSF biomarker in depression", and "major depressive disorder CSF"...
May 31, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28535694/what-insights-can-proteomics-give-us-into-iga-nephropathy-berger-s-disease
#8
Matthew B Renfrow, Jan Novak
No abstract text is available yet for this article.
May 29, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28532233/updates-on-sj%C3%A3-gren-s-syndrome-from-proteomics-to-protein-biomarkers
#9
Chiara Baldini, Antonella Cecchettini, Alessia Gallo, Stefano Bombardieri
Primary Sjögren's syndrome (pSS) is a complex heterogeneous autoimmune disorder, typically affecting exocrine glands. Recently, a great interest has arisen in searching for novel biomarkers able to improve the diagnostic work-up of the disease as well as the general assessment and the prognostic stratification of pSS patients. From this perspective, salivary proteomics has appeared as a promising tool considering that salivary proteins may closely reflect the underlying disease processes in the salivary glands...
May 26, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28532181/exploring-ribosome-composition-and-newly-synthesized-proteins-through-proteomics-and-potential-biomedical-applications
#10
Miroslava Stastna, Roberta A Gottlieb, Jennifer E Van Eyk
Protein synthesis is the outcome of tightly regulated gene expression which is responsive to a variety of conditions. Efforts are ongoing to monitor individual stages of protein synthesis to ensure maximum efficiency and accuracy. Due to post-transcriptional regulation mechanisms, the correlation between translatome and proteome is higher than between transcriptome and proteome. However, the most accurate approach to assess the key modulators and final protein expression is directly by using proteomics. Areas covered: This review covers various proteomic strategies that were used to better understand post-transcriptional regulation, specifically during and early after translation...
May 26, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28521569/exploring-the-biochemistry-of-the-prenylome-and-its-role-in-disease-through-proteomics-progress-and-potential
#11
Maura Brioschi, Alma Martinez Fernandez, Cristina Banfi
Protein prenylation is a ubiquitous covalent post-translational modification characterized by the addition of farnesyl or geranylgeranyl isoprenoid groups to a cysteine residue located near the carboxyl terminal of a protein. It is essential for the proper localization and cellular activity of numerous proteins, including Ras family GTPases and G-proteins. In addition to its roles in cellular physiology, the prenylation process has important implications in human diseases and in the recent years, it has become attractive target of inhibitors with therapeutic potential...
May 26, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28513226/application-of-proteomics-to-the-study-of-helicobacter-pylori-and-implications-for-the-clinic
#12
Giulia Bernardini, Natale Figura, Antonio Ponzetto, Barbara Marzocchi, Annalisa Santucci
Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the gastric epithelium and mucous layer of more than half the world's population. H. pylori is a primary human pathogen, responsible for the development of chronic gastritis, peptic ulceration and gastric cancer. Proteomics is impacting several aspects of medical research: understanding the molecular basis of infection and disease manifestation, identification of therapeutic targets and discovery of clinically relevant biomarkers. Areas covered: The main aim of the present review is to provide a comprehensive overview of the contribution of proteomics to the study of H...
May 26, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28524784/how-do-we-improve-treatments-for-patients-with-amyloidosis-using-proteomics
#13
Francesca Lavatelli, Giampaolo Merlini
No abstract text is available yet for this article.
May 23, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28448729/proteomics-of-blood-plasma-serum-samples-stored-in-biobanks-insights-for-clinical-application
#14
Jean-Daniel Tissot, Christine Currat, Dominique Sprumont
No abstract text is available yet for this article.
May 9, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28438056/mass-spectrometry-analysis-for-amyloidosis-typing-is-the-future-bright-for-its-clinical-implementation
#15
Michelle M Hill, Peter N Mollee
No abstract text is available yet for this article.
May 3, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28388239/can-protein-science-solve-the-unmet-needs-in-pancreatic-cancer-diagnosis-and-therapy
#16
Daniel Ansari, Fredrik Sambergs, Love Johansson, Roland Andersson
No abstract text is available yet for this article.
April 17, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28335651/from-mystery-to-mechanism-can-proteomics-build-systems-level-understanding-of-our-gut-microbes
#17
Carlos G Gonzalez, Lichao Zhang, Joshua E Elias
No abstract text is available yet for this article.
April 3, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28436239/clinical-applications-of-quantitative-proteomics-using-targeted-and-untargeted-data-independent-acquisition-techniques
#18
Jesse G Meyer, Birgit Schilling
While selected/multiple-reaction monitoring (SRM or MRM) is considered the gold standard for quantitative protein measurement, emerging data-independent acquisition (DIA) using high-resolution scans have opened a new dimension of high-throughput, comprehensive quantitative proteomics. These newer methodologies are particularly well suited for discovery of biomarker candidates from human disease samples, and for investigating and understanding human disease pathways. Areas covered: This article reviews the current state of targeted and untargeted DIA mass spectrometry-based proteomic workflows, including SRM, parallel-reaction monitoring (PRM) and untargeted DIA (e...
May 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28425787/defining-the-proteomic-landscape-of-rheumatoid-arthritis-progress-and-prospective-clinical-applications
#19
Lucía Lourido, Francisco J Blanco, Cristina Ruiz-Romero
The heterogeneity of Rheumatoid Arthritis (RA) and the absence of clinical tests accurate enough to identify the early stages of this disease have hampered its management. Therefore, proteomics research is increasingly focused on the discovery of novel biological markers, which would not only be able make an early diagnosis, but also to gain insight into the different pathological mechanisms underlying the heterogeneity of RA and also to stratify patients, which is critical to enabling effective treatments...
May 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28406322/mass-spectrometry-based-proteomic-exploration-of-the-human-immune-system-focus-on-the-inflammasome-global-protein-secretion-and-t-cells
#20
Tuula A Nyman, Martina B Lorey, Wojciech Cypryk, Sampsa Matikainen
The immune system is our defense system against microbial infections and tissue injury, and understanding how it works in detail is essential for developing drugs for different diseases. Mass spectrometry-based proteomics can provide in-depth information on the molecular mechanisms involved in immune responses. Areas covered: Summarized are the key immunology findings obtained with MS-based proteomics in the past five years, with a focus on inflammasome activation, global protein secretion, mucosal immunology, immunopeptidome and T cells...
May 2017: Expert Review of Proteomics
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