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Expert Review of Proteomics

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https://www.readbyqxmd.com/read/28425787/defining-the-proteomic-landscape-of-rheumatoid-arthritis-progress-and-prospective-clinical-applications
#1
Lucía Lourido, Francisco J Blanco, Cristina Ruiz-Romero
The heterogeneity of Rheumatoid Arthritis (RA) and the absence of clinical tests accurate enough to identify the early stages of this disease have hampered its management. Therefore, proteomics research is increasingly focused on the discovery of novel biological markers, which would not only be able make an early diagnosis, but also to gain insight into the different pathological mechanisms underlying the heterogeneity of RA and also to stratify patients, which is critical to enabling effective treatments...
April 20, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28406322/mass-spectrometry-based-proteomic-exploration-of-the-human-immune-system-focus-on-the-inflammasome-global-protein-secretion-and-t-cells
#2
Tuula A Nyman, Martina B Lorey, Wojciech Cypryk, Sampsa Matikainen
The immune system is our defense system against microbial infections and tissue injury, and understanding how it works in detail is essential for developing drugs for different diseases. Mass spectrometry-based proteomics can provide in-depth information on the molecular mechanisms involved in immune responses. Areas covered: Summarized are the key immunology findings obtained with MS-based proteomics in the past five years, with a focus on inflammasome activation, global protein secretion, mucosal immunology, immunopeptidome and T cells...
April 13, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28395554/monitoring-proteolytic-processing-events-by-quantitative-mass-spectrometry
#3
Mariel Coradin, Kelly R Karch, Benjamin A Garcia
Protease activity plays a key role in a wide variety of biological processes including gene expression, protein turnover and development. Misregulation of these proteins has been associated with many cancer types such as prostate, breast, and skin cancer. Thus, the identification of protease substrates will provide key information to understand proteolysis-related pathologies. Areas covered: Proteomics-based methods to investigate proteolysis activity, focusing on substrate identification, protease specificity and their applications in systems biology are reviewed...
April 11, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28395553/proteomics-and-irritable-bowel-syndrome
#4
Athanasios Tsigaridas, Ioannis S Papanikolaou, Anna Vaiopoulou, Athanasios K Anagnostopoulos, Nikos Viazis, George Karamanolis, Dimitrios G Karamanolis, George T Tsangaris, Gerasimos Mantzaris, Maria Gazouli
Irritable bowel syndrome (IBS) is a gastrointestinal disease that according to Rome IV criteria is subdivided into four subtypes. The pathophysiology of this disease is not well understood due to numerous factors playing multiple roles in disease development, such as diet, stress and hormones. IBS has a variety of symptoms and overlaps with many other gastrointestinal and non-gastrointestinal diseases. Area covered: This review aims to present an overview of implementation of proteomics in experimental studies in the field of IBS...
April 11, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28363249/applying-proteomics-to-detect-early-signs-of-chronic-kidney-disease-where-has-the-magic-gone
#5
Jon B Klein
No abstract text is available yet for this article.
April 10, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28361558/mining-the-fecal-proteome-from-biomarkers-to-personalised-medicine
#6
Ping Jin, Kui Wang, Canhua Huang, Edouard C Nice
Fecal proteomics has gained increased prominence in recent years. It can provide insights into the diagnosis and surveillance of many bowel diseases by both identifying potential biomarkers in stool samples and helping identify disease-related pathways. Fecal proteomics has already shown its potential for the discovery and validation of biomarkers for colorectal cancer screening, and the analysis of fecal microbiota by MALDI-MS for the diagnosis of a range of bowel diseases is gaining clinical acceptance. Areas covered: Based on a comprehensive analysis of the current literature, we introduce the range of sensitive and specific proteomics methods which comprise the current 'Proteomics Toolbox', explain how the integration of fecal proteomics with data processing/bioinformatics has been used for the identification of potential biomarkers for both CRC and other gut-related pathologies and analysis of the fecal microbiome, outline some of the current fecal assays in current clinical practice and introduce the concept of personalised medicine which these technologies will help inform...
April 10, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28388247/spit-it-out-how-could-the-sputum-proteome-aid-clinical-research-into-pulmonary-diseases
#7
Paolo Iadarola, Simona Viglio
No abstract text is available yet for this article.
April 7, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28388239/can-protein-science-solve-the-unmet-needs-in-pancreatic-cancer-diagnosis-and-therapy
#8
Daniel Ansari, Fredrik Sambergs, Love Johansson, Roland Andersson
No abstract text is available yet for this article.
April 7, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28335651/from-mystery-to-mechanism-can-proteomics-build-systems-level-understanding-of-our-gut-microbes
#9
Carlos G Gonzalez, Lichao Zhang, Joshua E Elias
No abstract text is available yet for this article.
March 24, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28281838/diagnostic-function-of-the-neuroinflammatory-biomarker-ykl-40-in-alzheimer-s-disease-and-other-neurodegenerative-diseases
#10
Filippo Baldacci, Simone Lista, Enrica Cavedo, Ubaldo Bonuccelli, Harald Hampel
Neuroinflammation is a crucial mechanism in the pathophysiology of neurodegenerative diseases pathophysiology. Cerebrospinal fluid (CSF) YKL-40 - an indicator of microglial activation - has recently been identified by proteomic studies as a candidate biomarker for Alzheimer's disease (AD). Areas covered: We review the impact of CSF YKL-40 as a pathophysiological biomarker for AD and other neurodegenerative diseases. CSF YKL-40 concentrations have been shown to predict progression from prodromal mild cognitive impairment to AD dementia...
March 20, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28271922/prion-like-proteins-and-their-computational-identification-in-proteomes
#11
Cristina Batlle, Valentin Iglesias, Susanna Navarro, Salvador Ventura
The aberrant or misfolded forms of the prion protein have been described as the causative agents of rare transmissible spongiform encephalopathies. In addition, proteins associated with frequently occurring neurodegenerative disorders, such as Alzheimer's and Parkinson's, are shown to share prion-like properties and to spread the disease in the brain. Areas covered: Interest in the prion phenomenon has crystallized in a series of computational methods aimed at uncovering prion-like proteins at the proteome level...
March 20, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28271730/recent-mass-spectrometry-based-proteomics-for-biomarker-discovery-in-lung-cancer-copd-and-asthma
#12
Kiyonaga Fujii, Haruhiko Nakamura, Toshihide Nishimura
Lung cancer and related diseases have been one of the most common causes of deaths worldwide. Genomic-based biomarkers may hardly reflect the underlying dynamic molecular mechanism of functional protein interactions, which is the center of a disease. Recent developments in mass spectrometry (MS) have made it possible to analyze disease-relevant proteins expressed in clinical specimens by proteomic challenges. Areas covered: To understand the molecular mechanisms of lung cancer and its subtypes, chronic obstructive pulmonary disease (COPD), asthma and others, great efforts have been taken to identify numerous relevant proteins by MS-based clinical proteomic approaches...
March 17, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28271739/role-of-the-microtubule-associated-tppp-p25-in-parkinson-s-and-related-diseases-and-its-therapeutic-potential
#13
Judit Oláh, Philippe Bertrand, Judit Ovádi
The discovery and development of therapeutic strategies for the treatments of Parkinson's disease (PD) and other synucleinopathies are limited by a lack of understanding of the pathomechanisms and their connection with different diseases such as cancers. Areas covered: The hallmarks of these diseases are frequently multifunctional disordered proteins displaying moonlighting and/or chameleon features, which are challenging drug targets. A representative of these proteins is the disordered Tubulin Polymerization Promoting Protein (TPPP/p25) expressed specifically in oligodendrocytes (OLGs) in normal brain...
March 15, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28271721/the-potential-impact-of-recent-insights-into-proteomic-changes-associated-with-glaucoma
#14
Sebastian Funke, Natarajan Perumal, Katharina Bell, Norbert Pfeiffer, Franz H Grus
Glaucoma, a major ocular neuropathy, is still far from being understood on a molecular scale. Proteomic workflows revealed glaucoma associated alterations in different eye components. By using state-of-the-art mass spectrometric (MS) based discovery approaches large proteome datasets providing important information about glaucoma related proteins and pathways could be generated. Corresponding proteomic information could be retrieved from various ocular sample species derived from glaucoma experimental models or from original human material (e...
March 8, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28276747/proteogenomic-studies-on-cancer-drug-resistance-towards-biomarker-discovery-and-target-identification
#15
Shuyue Fu, Xiang Liu, Maochao Luo, Ke Xie, Edouard C Nice, Haiyuan Zhang, Canhua Huang
Chemoresistance is a major obstacle for current cancer treatment. Proteogenomics is a powerful multi-omics research field that uses customized protein sequence databases generated by genomic and transcriptomic information to identify novel genes (e.g. noncoding, mutation and fusion genes) from mass spectrometry-based proteomic data. By identifying aberrations that are differentially expressed between tumor and normal pairs, this approach can also be applied to validate protein variants in cancer, which may reveal the response to drug treatment...
March 6, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28276748/using-proteomics-to-explore-the-effects-of-radiation-on-the-heart-impacts-for-medicine
#16
Soile Tapio
No abstract text is available yet for this article.
February 17, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28276749/unravelling-age-specific-differences-in-the-human-proteome-and-the-implications-for-medicine
#17
Stefan Bjelosevic, Vera Ignjatovic
No abstract text is available yet for this article.
February 13, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28162016/proteomic-studies-associated-with-parkinson-s-disease
#18
Murat Kasap, Gurler Akpinar, Aylin Kanli
Parkinson's disease (PD) is an insidious disorder affecting more than 1-2% of the population over the age of 65. Understanding the etiology of PD may create opportunities for developing new treatments. Genomic and transcriptomic studies are useful, but do not provide evidence for the actual status of the disease. Conversely, proteomic studies deal with proteins, which are real time players, and can hence provide information on the dynamic nature of the affected cells. The number of publications relating to the proteomics of PD is vast...
February 4, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28117610/the-power-of-tears-how-tear-proteomics-research-could-revolutionize-the-clinic
#19
Lei Zhou, Roger W Beuerman
No abstract text is available yet for this article.
February 1, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28099817/applying-proteomics-to-tick-vaccine-development-where-are-we
#20
Margarita Villar, Anabel Marina, José de la Fuente
Ticks are second to mosquitoes as a vector of human diseases and are the first vector of animal diseases with a great impact on livestock farming. Tick vaccines represent a sustainable and effective alternative to chemical acaricides for the control of tick infestations and transmitted pathogens. The application of proteomics to tick vaccine development is a fairly recent area, which has resulted in the characterization of some tick-host-pathogen interactions and the identification of candidate protective antigens...
January 27, 2017: Expert Review of Proteomics
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