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Expert Review of Proteomics

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https://www.readbyqxmd.com/read/29130774/the-sweet-spot-for-biologics-recent-advances-in-characterization-of-biotherapeutic-glycoproteins
#1
Rόisín O'Flaherty, Irena Trbojević-Akmačić, Gordon Greville, Pauline M Rudd, Gordan Lauc
Glycosylation is recognized as a Critical Quality Attribute for therapeutic glycoproteins such as monoclonal antibodies, fusion proteins and therapeutic replacement enzymes. Hence, efficient and quantitative glycan analysis techniques have been increasingly important for their discovery, development and quality control. The aim of this review is to highlight relevant and recent advances in analytical technologies for characterization of biotherapeutic glycoproteins. Areas covered: The review gives an overview of the glycosylation trends of biotherapeutics approved in 2016 and 2017 by FDA...
November 13, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29113513/quantifying-hdl-proteins-by-mass-spectrometry-how-many-proteins-are-there-and-what-are-their-functions
#2
Baohai Shao, Jay W Heinecke
Many lines of evidence indicate that low levels of HDL cholesterol increase the risk of cardiovascular disease (CVD). However, recent clinical studies of statin-treated subjects with established atherosclerosis cast doubt on the hypothesis that elevating HDL cholesterol levels reduces CVD risk. Areas covered: It is critical to identify new HDL metrics that capture HDL's proposed cardioprotective effects. One promising approach is quantitative MS/MS-based HDL proteomics. This article focuses on recent studies of the feasibility and challenges of using this strategy in translational studies...
November 8, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29106314/biomarkers-in-renal-transplantation
#3
Arjun Chakraborty, Minnie Sarwal
The standard of care for monitoring renal transplant patients include transplant biopsy and serum creatinine measurements. These are invasive procedures and are late and nonspecific markers of injury. Proteomics and proteins can provide biomarkers for monitoring pathology and become a useful tool in detection and treatment of conditions that occur after transplant. Areas covered: A survey of 273 studies in the biomarker detection field which included proteomics relating to renal pathology and normal controls was done...
November 6, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29041828/urine-protein-biomarkers-for-detection-of-cardiovascular-disease-and-their-use-for-the-clinic
#4
Sarah Röthlisberger, Johanna Pedroza-Diaz
Cardiovascular disease (CVD) is the leading noncommunicable disease and main cause of death worldwide. Traditionally, blood has been the sample of choice for biomarker discovery, however, urine has roused great interest in recent years as a source of biomarkers. Sample collection is simple, non-invasive, and there is the possibility of implementing minimal cost tests in primary care settings. Areas covered: In this review, we systematically searched PubMed for proteomic studies of CVD, with the criteria that urine was included as a biological sample...
October 27, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29025360/best-practice-of-identification-and-proteomic-analysis-of-extracellular-vesicles-in-human-health-and-disease
#5
Barbara W Sódar, Árpád Kovács, Tamás Visnovitz, Éva Pállinger, Károly Vékey, Gabriella Pocsfalvi, Lilla Turiák, Edit I Buzás
Extracellular vesicles are emerging sources of biomarkers for modern preventive and precision medicine. Extracellular vesicles in body fluids offer a unique opportunity for integrative biomarker approaches due to their complex biocargo that includes proteins, lipids, nucleic acids and metabolites. Mass spectrometry-based proteomics data suggest that a significant portion of human proteins are sorted into extracellular vesicles and amenable for biomarker discovery schemes. Areas covered: this review focuses on key aspects of isolation, quality control and subsequent analysis of blood plasma- and conditioned medium-derived extracellular vesicle proteins, and summarizes the current state-of-the-art in the field...
October 26, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29064727/proteomics-for-early-detection-of-colorectal-cancer-recent-updates
#6
Abdo Alnabulsi, Graeme I Murray
Colorectal cancer (CRC) is a common type of cancer with a relatively poor survival rate. The survival rate of patients could be improved if CRC is detected early. Biomarkers associated with early stages of tumor development might provide useful tools for the early diagnosis of colorectal cancer. Area covered: Online searches using PubMed and Google Scholar were performed using keywords and with a focus on recent proteomic studies. The aim of this review is to highlight the need for biomarkers to improve the detection rate of early CRC and provide an overview of proteomic technologies used for biomarker discovery and validation...
October 24, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29039980/advances-in-the-chromosome-centric-human-proteome-project-looking-to-the-future
#7
Young-Ki Paik, Gilbert S Omenn, Lydie Lane, Christopher M Overall
The mission of the Chromosome-Centric Human Proteome Project (C-HPP), is to map and annotate the entire predicted human protein set (~20,000 proteins) encoded by each chromosome. The initial steps of the project are focused on "missing proteins (MPs)", which lacked documented evidence for existence at protein level. In addition to remaining 2,579 MPs, we also target those annotated proteins having unknown functions, uPE1 proteins, alternative splice isoforms and post-translational modifications. We also consider how to investigate various protein functions involved in cis-regulatory phenomena, amplicons lncRNAs and smORFs...
October 17, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29039718/current-status-of-proteomics-of-soft-tissue-sarcomas
#8
Tadashi Kondo
Proteomics has been used in soft tissue sarcoma (STS) research in the attempts to improve the understanding of the disease background and develop novel clinical applications. Using various proteomics modalities, aberrant regulations of numerous intriguing proteins were identified in STSs, and the possible utilities of identified proteins as biomarkers or therapeutic targets have been explored. STS is an exceptionally diverse group of malignant diseases with highly complex molecular backgrounds and, therefore, an overview of the achievements and prospects of STS proteomics could enhance our knowledge of the possibilities and limitations of cancer proteomics...
October 17, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29039218/the-integration-of-genomics-testing-and-functional-proteomics-in-the-era-of-personalized-medicine
#9
Masaru Katoh
No abstract text is available yet for this article.
October 17, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29025353/mass-spectrometry-based-proteomics-analyses-in-kallikrein-related-peptidase-research-implications-for-cancer-research-and-therapy
#10
Lakmali Munasinghage Silva, Judith Ann Clements
Kallikrein-related peptidases (KLKs) are a family of serine peptidases that are deregulated in numerous pathological conditions, with a multitude of KLK-mediated functional roles implicated in the progression of cancer. Advances in multidimensional mass spectrometry (MS)-based proteomics have facilitated the quantitative measurement of deregulated KLK expression in cancer, identifying certain KLKs, as well as their substrates, as potential cancer biomarkers. Areas covered: In this review, we discuss how these approaches have been utilized for KLK biomarker discovery and unbiased substrate determination in complex protein pools that mimic the in vivo extracellular microenvironment...
October 13, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28990809/proteomic-interrogation-of-hsp90-and-insights-for-medical-research
#11
Lorenz Weidenauer, Tai Wang, Suhasini Joshi, Gabriela Chiosis, Manfredo R Quadroni
Heat shock protein 90 (HSP90) regulates protein homeostasis in eukaryotes. As a "professional interactor", HSP90 binds to and chaperones many proteins and has both housekeeping and disease-related functions but its regulation remains in part elusive. HSP90 complexes are a target for therapy, notably against cancer, and several inhibitors are currently in clinical trials. Proteomic studies have revealed the vast interaction network of HSP90 and, in doing so, the extent of cellular processes the chaperone takes part in, especially in yeast and human cells...
October 9, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28895440/unravelling-the-biology-of-chromatin-in-health-and-cancer-using-proteomic-approaches
#12
Cassandra G Eubanks, Gerald Dayebgadoh, Xingyu Liu, Michael P Washburn
Chromatin remodeling complexes play important roles in the control of genome regulation in both normal and diseased states, and are therefore critical components for the regulation of epigenetic states in cells. Given the role epigenetics plays in cancer, for example, chromatin remodeling complexes are routinely targeted for therapeutic intervention. Areas covered: Protein mass spectrometry and proteomics are powerful technologies used to study and understand chromatin remodeling. While impressive progress has been made in this area, there remain significant challenges in the application of proteomic technologies to the study of chromatin remodeling...
September 20, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28871888/subproteomic-signature-comparison-of-in-vitro-selected-fluoroquinolone-resistance-and-ciprofloxacin-stress-in-salmonella-typhimurium-dt104b
#13
Susana Correia, Michel Hébraud, Ingrid Chafsey, Christophe Chambon, Didier Viala, Carmen Torres, Manuela Caniça, José Luis Capelo, Patrícia Poeta, Gilberto Igrejas
BACKGROUND: Fluoroquinolone resistance in nontyphoidal Salmonella is a situation of serious and international concern, particularly in S. Typhimurium DT104B multiresistant strains. Although known to be multifactorial, fluoroquinolone resistance is still far from a complete understanding. METHODS: Subproteome changes between an experimentally selected fluoroquinolone-resistant strain (Se6-M) and its parent strain (Se6), and also in Se6-M under ciprofloxacin (CIP) stress, were evaluated in order to give new insights into the mechanisms involved...
September 18, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28893107/applying-proteomics-to-diagnosis-of-diabetic-kidney-disease
#14
Rafael Noal Moresco, José Antonio Mainardi De Carvalho
No abstract text is available yet for this article.
September 15, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28879805/venom-peptides-as-therapeutics-advances-challenges-and-the-future-of-venom-peptide-discovery
#15
Samuel D Robinson, Eivind A B Undheim, Beatrix Ueberheide, Glenn F King
Animal venoms are complex chemical arsenals. Most venoms are rich in bioactive peptides with proven potential as research tools, drug leads and drugs. Areas covered: We review recent advances in venom-peptide discovery, particularly the adoption of combined transcriptomic/proteomic approaches for the exploration of venom composition. Expert commentary: Advances in transcriptomics and proteomics have dramatically altered the manner and rate of venom-peptide discovery. The increasing trend towards a toxin-driven approach, as opposed to traditional target-based screening of venoms, is likely to expedite the discovery of venom-peptides with novel structures and new and unanticipated mechanisms of action...
September 13, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28786313/insights-from-protein-protein-interaction-studies-on-bacterial-pathogenesis
#16
Alla Gagarinova, Sadhna Phanse, Miroslaw Cygler, Mohan Babu
The threat bacterial pathogens pose to human health is increasing with the number and distribution of antibiotic-resistant bacteria, while the rate of discovery of new antimicrobials dwindles. Proteomics is playing key roles in understanding the molecular mechanisms of bacterial pathogenesis, and in identifying disease outcome determinants. The physical associations identified by proteomics can provide the means to develop pathogen-specific treatment methods that reduce the spread of antibiotic resistance and alleviate the negative effects of broad-spectrum antibiotics on beneficial bacteria...
September 8, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28870097/glycosylation-profiling-to-evaluate-glycoprotein-immunogens-against-hiv-1
#17
Anna-Janina Behrens, Weston B Struwe, Max Crispin
Much of the efforts to develop a vaccine against the human immunodeficiency virus (HIV) have focused on the design of recombinant mimics of the viral attachment glycoprotein (Env). The leading immunogens exhibit native-like antigenic properties and are being investigated for their ability to induce broadly neutralizing antibodies (bNAbs). Understanding the relative abundance of glycans at particular glycosylation sites on these immunogens is important as most bNAbs have evolved to recognize or evade the dense coat of glycans that masks much of the protein surface...
September 5, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28984473/the-continuing-evolution-of-cardiac-troponin-i-biomarker-analysis-from-protein-to-proteoform
#18
Daniel Soetkamp, Koen Raedschelders, Mitra Mastali, Kimia Sobhani, C Noel Bairey Merz, Jennifer Van Eyk
The troponin complex consists of three proteins that fundamentally couple excitation with contraction. Circulating cardiac-specific Troponin I (cTnI) serves as diagnostic biomarker tools for risk stratification of acute coronary syndromes and acute myocardial infarction (MI). Within the heart, cTnI oscillates between inactive and active conformations to either block or disinhibit actinomyosin formation. This molecular mechanism is fine-tuned through extensive protein modifications whose profiles are maladaptively altered with co-morbidities including hypertrophic cardiomyopathy, diabetes, and heart failure...
November 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28976223/proteomics-landscape-of-radiation-induced-cardiovascular-disease-somewhere-over-the-paradigm
#19
Omid Azimzadeh, Soile Tapio
Epidemiological studies clearly show that thoracic or whole body exposure to ionizing radiation increases the risk of cardiac morbidity and mortality. Radiation-induced cardiovascular disease (CVD) has been intensively studied during the last ten years but the underlying molecular mechanisms are still poorly understood. Areas covered: Heart proteomics is a powerful tool holding promise for the future research. The central focus of this review is to compare proteomics data on radiation-induced CVD with data arising from proteomics of healthy and diseased cardiac tissue in general...
November 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28974115/application-of-proteomics-to-graft-versus-host-disease-from-biomarker-discovery-to-potential-clinical-applications
#20
Richard B Presland
Graft-versus-host disease (GVHD) is a frequent and potentially life-threatening complication that occurs in many patients who undergo hematopoietic stem cell transplantation. In an effort to develop blood and tissue-based biochemical assays for GVHD diagnosis, high throughput proteomic platforms have been widely utilized for the identification and validation of disease biomarkers for both acute and chronic GVHD. Areas covered: This article reviews biomarker research findings on acute and chronic GVHD ascertained by studying peripheral blood, urine and saliva that gives biological information on systemic or localized disease...
November 2017: Expert Review of Proteomics
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