journal
MENU ▼
Read by QxMD icon Read
search

Expert Review of Proteomics

journal
https://www.readbyqxmd.com/read/28162022/proteomic-analysis-of-red-blood-cells-and-the-potential-for-the-clinic-what-have-we-learned-so-far
#1
Angelo D'Alessandro, Lello Zolla
Red blood cells (RBC) are the most abundant host cells in the human body. Mature erythrocytes are devoid of nuclei and organelles and have always been regarded as circulating "bags of hemoglobin". The advent of proteomics has challenged this assumption, revealing unanticipated complexity and novel roles for RBCs not just in gas transport, but also in systemic metabolic homeostasis in health and disease. Areas covered: In this review we will summarize the main advancements in the field of discovery mode and redox/quantitative proteomics with respect to RBC biology...
February 4, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28162016/proteomic-studies-associated-with-parkinson-s-disease
#2
Murat Kasap, Gurler Akpinar, Aylin Kanli
Parkinson's disease (PD) is an insidious disorder affecting more than 1-2% of the population over the age of 65. Understanding the etiology of PD may create opportunities for developing new treatments. Genomic and transcriptomic studies are useful, but do not provide evidence for the actual status of the disease. Conversely, proteomic studies deal with proteins, which are real time players, and can hence provide information on the dynamic nature of the affected cells. The number of publications relating to the proteomics of PD is vast...
February 4, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28117610/the-power-of-tears-how-tear-proteomics-research-could-revolutionize-the-clinic
#3
Lei Zhou, Roger W Beuerman
No abstract text is available yet for this article.
February 1, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28099817/applying-proteomics-to-tick-vaccine-development-where-are-we
#4
Margarita Villar, Anabel Marina, José de la Fuente
Ticks are second to mosquitoes as a vector of human diseases and are the first vector of animal diseases with a great impact on livestock farming. Tick vaccines represent a sustainable and effective alternative to chemical acaricides for the control of tick infestations and transmitted pathogens. The application of proteomics to tick vaccine development is a fairly recent area, which has resulted in the characterization of some tick-host-pathogen interactions and the identification of candidate protective antigens...
January 27, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28092721/use-of-maldi-tof-mass-spectrometry-in-the-battle-against-bacterial-infectious-diseases-recent-achievements-and-future-perspectives
#5
Vassilios Sandalakis, Ioannis Goniotakis, Iosif Vranakis, Dimosthenis Chochlakis, Anna Psaroulaki
Advancements in microbial identification occur increasingly faster as more laboratories explore, refine and extend the use of mass spectrometry in the field of microbiology. Areas covered: This review covers the latest knowledge found in the literature for quick identification of various classes of bacterial pathogens known to cause human infection by the use of MALDI-TOF MS technology. Except for identification of bacterial strains, more researchers try to 'battle time' in favor of the patient. These novel approaches to identify bacteria directly from clinical samples and even determine antibiotic resistance are extensively revised and discussed...
January 22, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28092479/prospects-for-proteomics-in-kidney-stone-disease
#6
Arada Vinaiphat, Visith Thongboonkerd
No abstract text is available yet for this article.
January 22, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28222617/presynaptic-calmodulin-targets-lessons-from-structural-proteomics
#7
Noa Lipstein, Melanie Göth, Christine Piotrowski, Kevin Pagel, Andrea Sinz, Olaf Jahn
Calmodulin (CaM) is a highly conserved Ca(2+)-binding protein that is exceptionally abundant in the brain. In the presynaptic compartment of neurons, CaM transduces changes in Ca(2+) concentration into the regulation of synaptic transmission dynamics. Areas covered: We review selected literature including published CaM interactor screens and outline established and candidate presynaptic CaM targets. We present a workflow of biochemical and structural proteomic methods that were used to identify and characterize the interactions between CaM and Munc13 proteins...
March 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28222616/plasma-biomarkers-for-the-identification-of-women-at-risk-for-early-onset-preeclampsia
#8
Aggeliki Kolialexi, George Th Tsangaris, Stavros Sifakis, Dimitris Gourgiotis, Aggeliki Katsafadou, Alexandra Lykoudi, Antonios Marmarinos, Danai Mavreli, Vassilis Pergialiotis, Dimitra Fexi, Ariadni Mavrou, George K Papaioanou, Nikolas Papantoniou
BACKGROUND: To identify potential biomarkers in the 1st trimester of pregnancy for the identification of women destined to develop early onset preeclampsia (EOPE). METHODS: Blood samples were obtained from pregnant women at 11-13 weeks of gestation. Women were followed up until delivery. Five samples from EOPE complicated pregnancies and 5 from unaffected ones were analysed using 2-DE and MALDI-TOF-TOF MS/MS. The altered expression of selected proteins was verified by ELISA in an extended sample cohort...
March 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28043171/the-story-of-protein-arginine-methylation-characterization-regulation-and-function
#9
Chao Peng, Catherine Cl Wong
Arginine methylation is an important post-translational modification (PTM) in cells, which is catalyzed by a group of protein arginine methyltransferases (PRMTs). It plays significant roles in diverse cellular processes and various diseases. Misregulation and aberrant expression of PRMTs can provide potential biomarkers and therapeutic targets for drug discovery. Areas covered: Herein, we review the arginine methylation literature and summarize the methodologies for the characterization of this modification, as well as describe the recent insights into arginine methyltransferases and their biological functions in diseases...
February 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28004597/functional-proteomic-insights-in-b-cell-chronic-lymphocytic-leukemia
#10
Paula Díez, Rafael Góngora, Alberto Orfao, Manuel Fuentes
B cell chronic lymphocytic leukemia (B-CLL) is a hematological malignancy considered as the most common leukemia in the Western world. The understanding of B cell differentiation is crucial for the diagnosis, prognosis, and treatment of the disease. Areas covered: In this review, B-cell ontogeny and its relation with the CLL development, in combination with the proteomic approaches which could provide a deep characterization of the disease through the characterization of the cellular signaling pathways involved in the pathological cells is described...
February 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28002974/proteomics-for-early-prenatal-screening-of-pregnancy-complications-a-2017-perspective
#11
Aggeliki Kolialexi, Danai Mavreli, Nikolas Papantoniou
No abstract text is available yet for this article.
February 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27997814/proteomics-in-cardiovascular-disease-recent-progress-and-clinical-implication-and-implementation
#12
Marika Mokou, Vasiliki Lygirou, Antonia Vlahou, Harald Mischak
Although multiple efforts have been initiated to shed light into the molecular mechanisms underlying cardiovascular disease, it still remains one of the major causes of death worldwide. Proteomic approaches are unequivocally powerful tools that may provide deeper understanding into the molecular mechanisms associated with cardiovascular disease and improve its management. Areas covered: Cardiovascular proteomics is an emerging field and significant progress has been made during the past few years with the aim of defining novel candidate biomarkers and obtaining insight into molecular pathophysiology...
February 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27967251/glycation-the-rage-axis-targeting-signal-transduction-through-diaph1
#13
Alexander Shekhtman, Ravichandran Ramasamy, Ann Marie Schmidt
The consequences of chronic disease are vast and unremitting; hence, understanding the pathogenic mechanisms mediating such disorders holds promise to identify therapeutics and diminish the consequences. The ligands of the receptor for advanced glycation end products (RAGE) accumulate in chronic diseases, particularly those characterized by inflammation and metabolic dysfunction. Although first discovered and reported as a receptor for advanced glycation end products (AGEs), the expansion of the repertoire of RAGE ligands implicates the receptor in diverse milieus, such as autoimmunity, chronic inflammation, obesity, diabetes, and neurodegeneration...
February 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27937063/recent-advances-in-proteomic-applications-for-schistosomiasis-research-potential-clinical-impact
#14
Javier Sotillo, Denise Doolan, Alex Loukas
Schistosomiasis is a neglected tropical disease affecting hundreds of millions of people worldwide. Recent advances in the field of proteomics and the development of new and highly sensitive mass spectrometers and quantitative techniques have provided new tools for advancing the molecular biology, cell biology, diagnosis and vaccine development for public health threats such as schistosomiasis. Areas covered: In this review we describe the latest advances in research that utilizes proteomics-based tools to address some of the key challenges to developing effective interventions against schistosomiasis...
February 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27935328/advances-of-the-hupo-human-proteome-project-with-broad-applications-for-life-sciences-research
#15
Gilbert S Omenn
No abstract text is available yet for this article.
February 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27997253/the-progress-and-potential-of-proteomic-biomarkers-for-type-1-diabetes-in-children
#16
Robert Moulder, Santosh Dilip Bhosale, Riitta Lahesmaa, David Robinson Goodlett
Although it is possible to identify the genetic risk for type 1 diabetes (T1D), it is not possible to predict who will develop the disease. New biomarkers are needed that would help understand the mechanisms of disease onset and when to administer targeted therapies and interventions. Areas covered: An overview is presented of international study efforts towards understanding the cause of T1D, including the collection of several extensive temporal sample series that follow the development of T1D in at risk children...
January 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27892738/methodological-approaches-and-insights-on-protein-aggregation-in-biological-systems
#17
Paulo Bastos, Fábio Trindade, Adelino Leite-Moreira, Inês Falcão-Pires, Rita Ferreira, Rui Vitorino
The proper folding of native proteins is critical and dynamic, but inherently unstable. Therefore, proteins eventually end up adopting misfolded conformations which compromise their function and may even trigger aggregation. Risk factors for neurodegenerative, metabolic and heart diseases compromise cellular protein quality-control systems, promoting protein aggregation. Multiple protein post-translational modifications dynamically regulate protein aggregation and disaggregation in a very complex, intricate and delicate balance...
January 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27885863/progress-and-pitfalls-in-finding-the-missing-proteins-from-the-human-proteome-map
#18
Victor Segura, Alba Garin-Muga, Elizabeth Guruceaga, Fernando J Corrales
The Human Proteome Project was launched with two main goals: the comprehensive and systematic definition of the human proteome map and the development of ready to use analytical tools to measure relevant proteins in their biological context in health and disease. Despite the great progress in this endeavour, there is still a group of reluctant proteins with no, or scarce, experimental evidence supporting their existence. These are called the 'missing proteins' and represent one of the biggest challenges to complete the human proteome map...
January 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27838931/proteomic-insights-into-extracellular-vesicle-biology-defining-exosomes-and-shed-microvesicles
#19
David W Greening, Rong Xu, Shashi K Gopal, Alin Rai, Richard J Simpson
Extracellular vesicles (EVs) are critical mediators of intercellular communication, capable of regulating the transcriptional landscape of target cells through horizontal transmission of biological information, such as proteins, lipids, and RNA species. This capability highlights their potential as novel targets for disease intervention. Areas covered: This review focuses on the emerging importance of discovery proteomics (high-throughput, unbiased quantitative protein identification) and targeted proteomics (hypothesis-driven quantitative protein subset analysis) mass spectrometry (MS)-based strategies in EV biology, especially exosomes and shed microvesicles...
January 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27838927/unlocking-the-proteomic-information-encoded-in-maldi-tof-ms-data-used-for-microbial-identification-and-characterization
#20
Clifton K Fagerquist
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) is increasingly utilized as a rapid technique to identify microorganisms including pathogenic bacteria. However, little attention has been paid to the significant proteomic information encoded in the MS peaks that collectively constitute the MS 'fingerprint'. This review/perspective is intended to explore this topic in greater detail in the hopes that it may spur interest and further research in this area. Areas covered: This paper examines the recent literature on utilizing MALDI-TOF for bacterial identification...
January 2017: Expert Review of Proteomics
journal
journal
40741
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"