journal
MENU ▼
Read by QxMD icon Read
search

Expert Review of Proteomics

journal
https://www.readbyqxmd.com/read/28099817/applying-proteomics-to-tick-vaccine-development-where-are-we
#1
Margarita Villar, Anabel Marina, José de la Fuente
Ticks are second to mosquitoes as a vector of human diseases and are the first vector of animal diseases with a great impact on livestock farming. Tick vaccines represent a sustainable and effective alternative to chemical acaricides for the control of tick infestations and transmitted pathogens. The application of proteomics to tick vaccine development is a fairly recent area, which has resulted in the characterization of some tick-host-pathogen interactions and the identification of candidate protective antigens...
January 18, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28092721/use-of-maldi-tof-mass-spectrometry-in-the-battle-against-bacterial-infectious-diseases-recent-achievements-and-future-perspectives
#2
Vassilios Sandalakis, Ioannis Goniotakis, Iosif Vranakis, Dimosthenis Chochlakis, Anna Psaroulaki
Advancements in microbial identification occur increasingly faster as more laboratories explore, refine and extend the use of mass spectrometry in the field of microbiology. Areas covered: This review covers the latest knowledge found in the literature for quick identification of various classes of bacterial pathogens known to cause human infection by the use of MALDI-TOF MS technology. Except for identification of bacterial strains, more researchers try to "battle time" in favor of the patient. These novel approaches to identify bacteria directly from clinical samples and even determine antibiotic resistance are extensively revised and discussed...
January 16, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28092479/prospects-for-proteomics-in-kidney-stone-disease
#3
Arada Vinaiphat, Visith Thongboonkerd
No abstract text is available yet for this article.
January 16, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28059571/presynaptic-calmodulin-targets-lessons-from-structural-proteomics
#4
Noa Lipstein, Melanie Göth, Christine Piotrowski, Kevin Pagel, Andrea Sinz, Olaf Jahn
Calmodulin (CaM) is a highly conserved Ca(2+)-binding protein that is exceptionally abundant in the brain. In the presynaptic compartment of neurons, CaM transduces changes in Ca(2+) concentration into the regulation of synaptic transmission dynamics. Areas covered: We review selected literature including published CaM interactor screens and outline established and candidate presynaptic CaM targets. We present a workflow of biochemical and structural proteomic methods that were used to identify and characterize the interactions between CaM and Munc13 proteins...
January 6, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27791437/urinary-biomarkers-for-renal-tract-malformations
#5
Pedro Magalhães, Joost P Schanstra, Emma Carrick, Harald Mischak, Petra Zürbig
Renal tract malformations (RTMs) are congenital anomalies of the kidneys and urinary tract, which are the major cause of end-stage renal disease in children. Using immunoassay-based approaches (ELISA, western blot), individual urinary proteins including transforming growth factor β, tumor necrosis factor and monocyte attractant proteins 1 were found to be associated to RTMs. However, only mass spectrometry (MS) based methods leading to the identification of panels of protein-based markers composed of fragments of the extracellular matrix allowed the prediction of progression of RTMs and its complications...
November 15, 2016: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27813434/toxicoproteomics-in-human-health-and-disease-an-update
#6
Shankar Suman, Sanjay Mishra, Yogeshwer Shukla
Toxicoproteomics is an emerging area of omics, intended to explore the changes in protein expression and modifications in biological samples exposed to toxicants. The development of techniques that utilize sophisticated instruments in proteomics has facilitated the exploration of a wide-range of protein coverage and assisted the quantitative and qualitative evaluation of protein changes as a result of the toxic effects of toxic substances. Areas covered: Studies on toxicoproteomics have an immense potential to explore the molecular mechanism of action of a variety of toxic substances through deciphering the proteomic map altered as a result of toxicant exposure...
November 11, 2016: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27771981/blood-biomarker-discovery-in-drug-free-schizophrenia-the-contribution-of-proteomics-and-multiplex-immunoassays
#7
Sophie Sabherwal, Jane A English, Melanie Föcking, Gerard Cagney, David R Cotter
Recent evidence supports an association between systemic abnormalities and the pathology of psychotic disorders which has led to the search for peripheral blood-based biomarkers. Areas covered: Here, we summarize blood biomarker findings in schizophrenia from the literature identified by two methods currently driving biomarker discovery in the human proteome; mass spectrometry and multiplex immunoassay. From a total of 14 studies in the serum or plasma of drug-free schizophrenia patients; 47 proteins were found to be significantly altered twice or more, in the same direction...
November 11, 2016: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27798968/prospective-applications-of-ultrahigh-resolution-proteomics-in-clinical-mass-spectrometry
#8
L Renee Ruhaak, Yuri E M van der Burgt, Christa M Cobbaert
Advances in mass spectrometry (MS)-based proteomic strategies have resulted in robust protein biomarker discovery studies often performed on high resolution accurate mass (HRAM) platforms. For successful translation of promising protein biomarkers into useful clinical tests, trans-sector networks and collaboration among stakeholders involved in the biomarker pipeline are urgently needed. Areas covered: In this perspective, literature- and empirical evidence is combined with author's opinions to discuss the progress of ultrahigh resolution MS and provide insight in its potential for validation and development of clinical tests...
November 7, 2016: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27774815/immunomic-approaches-for-antigen-discovery-of-human-parasites
#9
Kokouvi Kassegne, Eniola Michael Abe, Jun-Hu Chen, Xiao-Nong Zhou
Genetics combined with proteomics allows for a better understanding of parasite-host interactions and host immune responses. Immunomics elucidates that antigens are targets of induced or naturally acquired immunity (NAI), a promising solution to the challenge of eradicating human infections. High-throughput protein microarrays enhance rapid antigen discovery for the development of serodiagnostic tests/vaccines. Areas covered: This review systematically analyzes the emergence of protein microarrays as a powerful technology for parasite antigen discovery and subsequently summarizes some of the attributes and disadvantages of these approaches...
November 7, 2016: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27744719/progress-and-prospects-for-the-discovery-of-biomarkers-for-gastric-cancer-a-focus-on-proteomics
#10
Yasuhiko Mohri, Yuji Toiyama, Masato Kusunoki
Patient outcomes from gastric cancer vary due to the complexity of stomach carcinogenesis. Recent research using proteomic technologies has targeted components of all of these systems in order to develop biomarkers to aid the early diagnosis of gastric cancer and to assist in prognostic stratification. Areas covered: This review is comprised of evidence obtained from literature searches from PubMed. It covers the evidence of diagnostic, prognostic, and predictive biomarkers for gastric cancer using proteomic technologies, and provides up-to-date references...
October 31, 2016: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27748142/the-proteomic-landscape-of-renal-tumors
#11
Clizia Chinello, Vincenzo L'imperio, Martina Stella, Andrew James Smith, Giorgio Bovo, Angelica Grasso, Marco Grasso, Francesca Raimondo, Marina Pitto, Fabio Pagni, Fulvio Magni
Renal cell carcinoma (RCC) is the most fatal of the common urologic cancers, with approximately 35% of patients dying within 5 years following diagnosis. Therefore, there is a need for non-invasive markers that are capable of detecting and determining the severity of small renal masses at an early stage in order to tailor treatment and follow-up. Proteomic studies have proved to be very useful in the study of tumors. Areas covered: In this review, we will detail the current knowledge obtained by the different proteomic approaches, focusing on MS-based strategies, used to investigate RCC biology in order to identify diagnostic, prognostic and predictive biomarkers on tissue, cultured cells and biological fluids...
October 28, 2016: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28043171/the-story-of-protein-arginine-methylation-characterization-regulation-and-function
#12
Chao Peng, Catherine Cl Wong
Arginine methylation is an important post-translational modification (PTM) in cells, which is catalyzed by a group of protein arginine methyltransferases (PRMTs). It plays significant roles in diverse cellular processes and various diseases. Misregulation and aberrant expression of PRMTs can provide potential biomarkers and therapeutic targets for drug discovery. Areas covered: Herein, we review the arginine methylation literature and summarize the methodologies for the characterization of this modification, as well as describe the recent insights into arginine methyltransferases and their biological functions in diseases...
February 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28004597/functional-proteomic-insights-in-b-cell-chronic-lymphocytic-leukemia
#13
Paula Díez, Rafael Góngora, Alberto Orfao, Manuel Fuentes
B cell chronic lymphocytic leukemia (B-CLL) is a hematological malignancy considered as the most common leukemia in the Western world. The understanding of B cell differentiation is crucial for the diagnosis, prognosis, and treatment of the disease. Areas covered: In this review, B-cell ontogeny and its relation with the CLL development, in combination with the proteomic approaches which could provide a deep characterization of the disease through the characterization of the cellular signaling pathways involved in the pathological cells is described...
February 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28002974/proteomics-for-early-prenatal-screening-of-pregnancy-complications-a-2017-perspective
#14
Aggeliki Kolialexi, Danai Mavreli, Nikolas Papantoniou
No abstract text is available yet for this article.
February 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27997814/proteomics-in-cardiovascular-disease-recent-progress-and-clinical-implication-and-implementation
#15
Marika Mokou, Vasiliki Lygirou, Antonia Vlahou, Harald Mischak
Although multiple efforts have been initiated to shed light into the molecular mechanisms underlying cardiovascular disease, it still remains one of the major causes of death worldwide. Proteomic approaches are unequivocally powerful tools that may provide deeper understanding into the molecular mechanisms associated with cardiovascular disease and improve its management. Areas covered: Cardiovascular proteomics is an emerging field and significant progress has been made during the past few years with the aim of defining novel candidate biomarkers and obtaining insight into molecular pathophysiology...
February 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27967251/glycation-the-rage-axis-targeting-signal-transduction-through-diaph1
#16
Alexander Shekhtman, Ravichandran Ramasamy, Ann Marie Schmidt
The consequences of chronic disease are vast and unremitting; hence, understanding the pathogenic mechanisms mediating such disorders holds promise to identify therapeutics and diminish the consequences. The ligands of the receptor for advanced glycation end products (RAGE) accumulate in chronic diseases, particularly those characterized by inflammation and metabolic dysfunction. Although first discovered and reported as a receptor for advanced glycation end products (AGEs), the expansion of the repertoire of RAGE ligands implicates the receptor in diverse milieus, such as autoimmunity, chronic inflammation, obesity, diabetes, and neurodegeneration...
February 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27937063/recent-advances-in-proteomic-applications-for-schistosomiasis-research-potential-clinical-impact
#17
Javier Sotillo, Denise Doolan, Alex Loukas
Schistosomiasis is a neglected tropical disease affecting hundreds of millions of people worldwide. Recent advances in the field of proteomics and the development of new and highly sensitive mass spectrometers and quantitative techniques have provided new tools for advancing the molecular biology, cell biology, diagnosis and vaccine development for public health threats such as schistosomiasis. Areas covered: In this review we describe the latest advances in research that utilizes proteomics-based tools to address some of the key challenges to developing effective interventions against schistosomiasis...
February 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27935328/advances-of-the-hupo-human-proteome-project-with-broad-applications-for-life-sciences-research
#18
Gilbert S Omenn
No abstract text is available yet for this article.
February 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27997253/the-progress-and-potential-of-proteomic-biomarkers-for-type-1-diabetes-in-children
#19
Robert Moulder, Santosh Dilip Bhosale, Riitta Lahesmaa, David Robinson Goodlett
Although it is possible to identify the genetic risk for type 1 diabetes (T1D), it is not possible to predict who will develop the disease. New biomarkers are needed that would help understand the mechanisms of disease onset and when to administer targeted therapies and interventions. Areas covered: An overview is presented of international study efforts towards understanding the cause of T1D, including the collection of several extensive temporal sample series that follow the development of T1D in at risk children...
January 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27892738/methodological-approaches-and-insights-on-protein-aggregation-in-biological-systems
#20
Paulo Bastos, Fábio Trindade, Adelino Leite-Moreira, Inês Falcão-Pires, Rita Ferreira, Rui Vitorino
The proper folding of native proteins is critical and dynamic, but inherently unstable. Therefore, proteins eventually end up adopting misfolded conformations which compromise their function and may even trigger aggregation. Risk factors for neurodegenerative, metabolic and heart diseases compromise cellular protein quality-control systems, promoting protein aggregation. Multiple protein post-translational modifications dynamically regulate protein aggregation and disaggregation in a very complex, intricate and delicate balance...
January 2017: Expert Review of Proteomics
journal
journal
40741
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"